JP2021052944A - Suppository capsule material - Google Patents

Abstract

To prevent a suppository from dropping due to intestine and vaginal contraction or ejection of a body gas.SOLUTION: A suppository capsule material includes a tip tetra-part 12 serving as an insertion side and a columnar cylindrical part 15 continuously installed in a rear end of the tip tetra-part. The suppository capsule material is assumed as a technical premise, and a direction operation part 17 with a spherical surface is provided in the rear end of the columnar cylindrical part 15 (claim 1). By providing the direction operation part with the spherical surface, when the direction operation part positioned in the rear end is pushed in an appropriate direction of top/bottom and left/right directions in the insertion of the suppository, the spherical surface of the suppository capsule material slides between a body wall surface and itself, and the capsule material is turned. When the capsule material is turned to the insertion direction, the suppository can take a sideways-facing posture in the intestine or the vagina. While the tip surface of the tip tetra-part of the insertion side and the rear end surface of the direction operation part are brought into contact with the internal wall, the suppository capsule material is made to stay and is maintained. A contact pressure with the internal wall is high, and therefore dropping and the like are prevented from being caused in normal use.SELECTED DRAWING: Figure 1

Description

The present invention relates to a suppository capsule material, and more particularly to a shape technique for preventing the inserted suppository from falling off.

Suppositories (insertions, suppositories; hereinafter referred to as suppositories) are used by inserting them into the body for the purpose of treating intestinal diseases, hemorrhoids, and other diseases, reducing fever, and analgesia. The anus or vagina is often used as the insertion site for suppositories.

Since a suppository encloses a drug in a water-soluble capsule material and inserts the drug into the body, the shape of the capsule material is conventionally formed into a so-called bullet shape or a cannonball shape so that the suppository can be smoothly inserted into the body.

Specifically, for example, there is one shown in FIG. 8 (Patent Document 1).

The suppository capsule material 1 includes a tip tetra portion 2 on the insertion side and a columnar cylinder portion 3 connected to the rear end of the tip tetra portion 2. The tip tetra portion 2 has a circular horizontal cross section whose diameter gradually expands toward the rear when the insertion direction is forward, and the columnar tubular portion 3 is formed into a tubular shape having substantially the same horizontal cross section diameter. ..

Reference numeral 4 denotes a hollow portion (distribution portion) penetrating from the front end surface of the tip tetra portion 2 to the rear end surface of the columnar cylinder portion 3. The hollow portion 4 has a function of preventing the suppository from coming off due to intestinal gas.

The suppository capsule material 1 inserted into the body is in close contact with the internal wall portion of the insertion site and stays at the insertion site due to friction with the internal wall portion. When the suppository capsule material 1 melts after a certain period of time, the internal drug flows out, and the drug component is absorbed through the body wall and sent into the body.

Japanese Patent Application Laid-Open No. 5-279243

The problem is that conventional suppositories tend to fall out of the insertion site.

Conventional suppositories are premised on staying at the insertion site due to the close contact between the capsule material and the body wall, but if the intestine or vagina contracts for some reason such as changing posture, the suppository capsule material It slides so that the outer peripheral surface of the capsule is squeezed out, and often slips out of the body.

In the invention of Patent Document 1, since the body gas can be released from the hollow portion (circulation part) when the body gas is released, it is possible to prevent the body gas from falling out due to the body gas.

However, it is difficult to prevent the capsule material from sliding or pushing out due to contraction of the intestine or vagina.

Therefore, an object of the present invention is to prevent the suppository from falling off due to contraction of the intestine or vagina, release of gas in the body, or the like.

In order to achieve the above object, the suppository capsule material according to the present invention is a suppository capsule material including a tip tetra portion on the insertion side and a columnar tubular portion connected to the rear end of the tip tetra portion. As a technical premise, a directional control portion having a spherical surface is provided at the rear end portion of the columnar cylinder portion (claim 1).

By providing a directional control portion that exhibits a spherical surface, when the suppository is inserted, the directional control portion located at the rear end is pushed in the appropriate directions up, down, left, and right, and the spherical surface of the suppository capsule material is brought into contact with the internal wall surface. It slips between them and the suppository capsule material rotates.

When the suppository capsule material is rotated at an appropriate angle, for example, approximately 90 degrees with respect to the insertion direction, the suppository can take a sideways posture in the intestine or vagina.

In this case, the suppository capsule material is retained and maintained in a state where the tip surface of the tip tetra portion on the insertion side and the rear end surface of the directional control portion exhibiting a spherical shape are in contact with the body wall. Although the contact area is small, the contact pressure with the body wall is high, so that problems (such as falling off) during normal use do not occur.

On the other hand, since the suppository capsule material can take a sideways posture, even if the intestine or vagina contracts for some reason, the contact area between the suppository capsule material and the body wall is small, and as a result, the suppository is pushed out by sliding. , It is less likely to fall out.

A plurality of recesses may be formed on the surface of the directional control unit (claim 2).

When pushing the suppository with a finger, the finger touching the spherical surface may slip. Therefore, if a few recesses are provided on the spherical surface, the finger slippage can be suppressed and the suppository can be inserted. It becomes easier to operate the direction.

The directional control unit need only have a spherical surface, and does not necessarily have to be a perfect sphere. This is because the purpose of providing the directional control portion can be achieved if the insertion angle of the suppository can be changed at the time of insertion. The shape of the rear end can be appropriately designed, such as a shape close to a sphere and the rear end being cut horizontally at an appropriate position.

According to the capsule material for suppositories according to the present invention, it is possible to prevent the suppository from falling off due to contraction of the intestine or vagina, release of gas in the body, or the like.

It is a figure which shows the suppository capsule material which concerns on 1st Embodiment from the side. It is a top view of the suppository capsule material shown in FIG. It is a figure which shows the insertion example of the capsule material for a suppository shown in FIG. It is a figure which illustrates the use state in which the suppository capsule material shown in FIG. 1 is rolled over. It is a figure which shows the suppository capsule material which concerns on 2nd Embodiment from the side. It is a bottom view of the suppository capsule material shown in FIG. It is a figure which shows the suppository capsule material which concerns on 3rd Embodiment from the side. It is a figure which shows the conventional capsule material for a suppository.

1 and 2 show the first embodiment of the suppository capsule material according to the present invention.

Reference numeral 11 denotes a suppository capsule material, and the suppository (insertion agent) 10 can be prepared by loading the suppository capsule material 11 with a drug.

Reference numeral 12 denotes a tip tetra portion on the insertion side of the suppository 10, 13 is a tip surface of the tip tetra portion 12, and 15 is a columnar cylinder portion continuously provided at the rear end of the tip tetra portion 12.

Reference numeral 17 denotes a directional control portion having a spherical surface provided at the rear end portion of the columnar tubular portion 15. In this embodiment, the directional control portion 17 is formed into a substantially spherical shape whose rear end portion is also spherical.

Similar to the conventional capsule material for suppositories, the shapes / dimensions of the tip tetra portion 12 and the columnar tubular portion 15 can be slightly changed as needed. For example, the tip surface 13 of the tip tetra portion 12 may be a curved surface, and the columnar tubular portion 15 may have a slightly thinner intermediate portion in the longitudinal direction.

The conventional capsule material for suppositories has a dimension of about 30 mm from the tip surface 13 of the tip tetra portion 12 to the rear end surface of the columnar cylinder portion 15, but the capsule material 11 for suppositories according to the present embodiment is omitted. Since the spherical directional control portion 17 is provided, the longitudinal dimension of the columnar tubular portion 15 is preferably formed to be slightly shorter.

The directional control portion 17 is formed by being continuously provided with, for example, the rear end portion of the columnar cylinder portion 15. The directional control unit 17 is a means for changing the insertion direction of the suppository capsule material 11, and it is not necessary to load the drug inside. When it is assumed that the drug is loaded inside, the substantially spherical directional control portion 17 and the columnar cylinder portion 15 are spatially communicated with each other. On the other hand, when the chemical is not loaded into the directional control unit 17, the rear end surface of the columnar cylinder portion 15 or the connection surface of the directional control unit 17 may be closed. However, it is desirable that the directional control unit 17 is formed into a hollow inside in order to expedite melting in the body.

It is desirable that the size of the directional control portion 17 is designed to be slightly larger than that of the columnar cylinder portion 15. For example, when the short side dimension (outer dimension) of the columnar cylinder portion 15 is 10 mm, the diameter (outer dimension) of the directional control portion 17 is set to 15 mm. Since the size of the columnar cylinder portion 15 also changes depending on the type and purpose of the suppository 10, the diameter of the directional control portion 17 is also appropriately changed according to the size of the columnar cylinder portion 15.

The larger the diameter, the better the operability of the directional control unit 17 for manipulating the direction with a finger, but it is difficult to make it excessively large because it is inserted into the body. Preferably, for example, the diameter of the directional control portion 17 is suppressed to about 30 to 60% larger than the lateral dimension of the columnar cylinder portion 15.

As the raw material of the capsule material 11 for suppositories, for example, gelatin, hydroxypropylmethyl cellulose and the like can be used as in the case of conventional suppositories. Gelatin is preferred for strength and safety reasons. As long as it is a water-soluble material that can guarantee safety and strength, the raw material can be appropriately selected and used.

According to this configuration, when the suppository 10 is inserted into the body (for example, rectum R), as shown in FIG. 3, the tip of the suppository 10 is rotated by rotating the directional control unit 17 in the direction of the arrow A, for example. Can be rotated in the direction opposite to the arrow A. This is because the directional control unit 17 is a substantially sphere, so that it rotates smoothly in the rectum in accordance with the operation by the finger.

Finally, as shown in FIG. 4, for example, when the suppository 10 is turned sideways in the rectum R, the tip surface 13 of the tip tetra portion 12 and the rear end portion of the directional control portion 17 are the inner wall of the rectum R. And stays in the body in a state of being sandwiched by the pressure of the rectum R.

The suppository 10 that stays sideways is difficult to move due to the contraction of the rectum R, and the possibility of falling out of the body is significantly reduced. Conventional suppositories stay in the body due to friction with the rectal R. Therefore, when the rectum R contracted, it was easy to slip out of the body due to peristaltic movement. However, when the suppository 10 is turned sideways, peristaltic movement due to contraction is unlikely to occur. This is because from the beginning, it is sandwiched and stays under the pressure of the rectum R.

When the suppository 10 is in a posture perpendicular to the rectum R, there is a space around the suppository 10. Therefore, the gas in the body can be discharged to the outside of the body without being blocked by the suppository 10.

In FIG. 3, it is shown that there is a gap between the rectum R and the suppository 10 for easy understanding, but in reality, there is no gap. Further, in FIG. 4, the spread of the rectum R around the suppository 10 is exaggerated, but in reality, only the portion of the sideways suppository 10 is locally spread. Since the suppository capsule material 11 spreads in a short time and in a limited manner until it melts, problems such as damage to the rectal R do not occur.

5 and 6 show the suppository capsule material 21 according to the second embodiment.

In this suppository capsule material 21, the directional control portion 27 is formed into a substantially hemispherical shape, and the rear end surface 28 of the directional control portion 27 is made into a flat plate surface (see FIG. 5). Since the tip tetra portion 12 and the columnar tubular portion 15 are the same as those in the first embodiment, they are designated by the same reference numerals and duplicated description will be omitted.

The directional control unit 27 may have a function of changing the insertion angle of the suppository 10. As shown in the first embodiment, it is most desirable to make it substantially spherical, but even if it is hemispherical, the spherical surface rotates smoothly in the rectum R, and the suppository 10 is substantially perpendicular to the rectum R. You can take the posture of.

The advantage of the hemispherical shape is that the package case can be made smaller by shortening the longitudinal dimension, and the efficiency of transportation and storage can be improved accordingly.

In order to increase the area of the spherical surface of the hemispherical directional control unit 27, it is desirable to provide the rear end surface 28 slightly behind the center point of the sphere (see FIG. 6).

Further, in the case of the hemispherical directional control portion 27, the rear end surface 28 may be formed into an appropriate shape such as a conical shape instead of a flat plate shape.

FIG. 7 shows the suppository capsule material 31 according to the third embodiment.

The suppository capsule material 31 forms a plurality of recesses 38 on the surface of the substantially spherical directional control portion 37. This is to prevent the finger from slipping when the substantially spherical directional control unit 37 is operated by the finger. Since the other configurations are the same as those in the first embodiment, the same reference numerals are given and duplicate description will be omitted.

A plurality of recesses are provided so as to prevent the fingers from slipping. The recess 38 does not need to be formed deeply as long as it can prevent the finger from slipping, and a small shallow curved recess may be used. The external shape of the recess 38 may be a circle, an ellipse, or a rectangle.

10 Suppository (insertion drug)
11, 21, 31 Capsule material for suppository 12 Tip tetra part 13 Tip surface of tip tetra part 15 Columnar cylinder part 17, 27, 37 Directional operation part 28 Rear end surface (of directional operation part) 38 Concave R rectum

Claims (2)

The tip tetra part on the insertion side and
In a suppository capsule material provided with a columnar tubular portion connected to the rear end of the tip tetra portion.
At the rear end of the columnar cylinder
A suppository capsule material characterized by providing a directional control portion that exhibits a spherical surface. On the surface of the directional control unit
The capsule material for a suppository according to claim 1, wherein a plurality of recesses are formed.

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