JP2021029443A - Blood processing apparatus and blood-containing material collection device - Google Patents

Abstract

To provide a blood processing apparatus in which blood can be purified by a remover, and degradation of a blood flow in the remover can be inhibited.SOLUTION: A blood processing apparatus 10 includes: a blood circuit C where the blood from a patient is returned to the patient; a mixer 30 interposed in the blood circuit; a fine air bubble water generation device 20 for generating fine air bubble water mixed through a mixer, the fine air bubble water that contains fine air bubbles electrically charged in negative potential; a remover 40 for removing a removal object contained in the blood mixed by the mixer; and a charger 50 for imparting positive potential to the remover. The remover includes porous hollow fibers 42 where a sealing layer containing a charged body electrically charged by the charger is formed in an outer circumferential surface, and the blood is made to flow. Fine air bubbles adsorbing and taking waste material, plaque pieces and oxidized cholesterol are taken in the fine holes of the porous hollow fibers by using the remover.SELECTED DRAWING: Figure 1

Description

The present invention relates to a blood processing device that removes an object to be removed from blood, and a blood-containing substance collecting device that collects the object to be removed in order to inspect the object to be removed.

It is known that a patient is treated with fine bubble water containing fine bubbles called nanobubbles (see, for example, Patent Document 1).
In the treatment apparatus described in Patent Document 1, fine bubble water containing fine bubbles charged at a negative potential is charged into a patient together with an input solution such as a chemical solution or a nutrient solution. By doing so, the input liquid such as the chemical solution or the nutrient solution is adsorbed on the spherical surface of the fine bubbles charged with a negative potential, and the drug solution is transported in the blood in a state where the drug solution is a drug film and the nutrient is a nutrient film. By functioning as a capsule, drugs and nutrient solutions carried by microbubbles can be distributed throughout the body.

Further, in the treatment device described in Patent Document 1, a hollow tubular portion through which blood flows, an electrode portion formed along the inner peripheral surface of the tubular portion and to which a positive voltage is applied, and a tubular portion. A remover provided at both ends on the inlet and outlet sides and with a plug to which an arterial circuit is connected is described.

In this remover, hydrogen microbubbles charged with a negative potential are adsorbed and taken in by waste products with a positive potential, plaque fragments exfoliated from the blood vessel wall, and corsterol oxide in the blood, so that a positive voltage is generated. Waste products, plaque fragments, and corsterol oxide are attracted to the applied electrode portion and removed from the blood.

Japanese Patent No. 6189562

However, if the hollow tubular part through which blood flows is formed by a glass tube, blood may coagulate on the inner surface of the glass tube, and the coagulation of blood deteriorates the blood flow passing through the remover. There is a risk.
Further, in the treatment device described in Patent Document 1, only a substance having an adverse effect on the patient is removed by a remover. In conventional tests such as blood and urine, a small amount of sample is analyzed for diagnosis, and the accuracy is limited, and a precise and accurate test cannot be performed, which has a drawback of delaying early detection.

Therefore, an object of the present invention is to provide a blood processing apparatus capable of purifying blood by a remover and suppressing deterioration of blood flow in the remover.
Another object of the present invention is to provide a blood-containing substance collecting device capable of detecting a wide variety of diseases at an early stage with high accuracy.

The blood treatment apparatus of the present invention is a blood circuit in which blood collected from a patient is returned to the patient, a mixer interposed in the blood circuit, and fine bubble water mixed via the mixer. The remover includes a fine bubble water generator that generates fine bubble water containing fine bubbles that are charged to a negative potential, a remover that removes an object to be removed contained in blood mixed by the mixer, and the remover. The remover is provided with a charging device for applying a positive potential, and the removing device is provided with a porous hollow thread in which a sealing layer containing a charged body charged by the charging device is formed on the outer peripheral surface and blood flows. It is characterized by.

According to the blood treatment apparatus of the present invention, blood flow occurs when fine bubbles charged at a negative potential adsorb and take in an object to be removed, flow from a blood circuit to a remover, and pass through a porous hollow fiber. The blood is attracted to the sealing layer on the outer peripheral surface of the porous hollow fiber, which has a positive potential in the charging device, and is taken into the fine pores of the porous hollow fiber. Therefore, since the object to be removed that adversely affects the patient can be removed, the blood can be purified. Further, since the porous hollow fiber does not coagulate or is difficult to coagulate, it is possible to make it difficult for the object to be removed to obstruct the blood flow passing through the porous hollow fiber.

When the charged body is formed of glass powder, the fine bubbles charged at a negative potential can be charged at a positive potential, so that the fine cells can be attracted to the sealing layer.

Cellulose nanofibers can be contained in the sealing layer as a sealing material. Since the cellulose nanofibers used as the sealing material for the sealing layer are of natural origin, they do not adversely affect blood.

Only the unnecessary removal target is removed by providing the blood circuit with a replacement fluid supply device that replenishes the essential component and / and the active ingredient necessary for the body removed together with the removal target from the blood by the removal device. Blood can be returned to the patient in this state.

The blood-containing substance collecting device of the present invention pulls the object to be removed adhering to the fine pores of the inner wall of the porous hollow thread of the remover removed from the blood treatment device of the present invention from the micropores as a collection target. It is characterized by including an injector for injecting a peeling liquid to be peeled off, an ultrasonic vibration generator for applying vibration to the remover, and a collector for collecting an object to be collected from the remover.

According to the blood-containing substance collecting device of the present invention, the stripping liquid from the injector flowing through the remover pulls the object to be collected taken into the micropores of the porous hollow fiber from the porous hollow fiber and the sealing layer. Peel off. Further, since the ultrasonic vibration generated by the ultrasonic vibrator is applied to the remover, it is possible to promote the peeling of the object to be collected adsorbed on the remover by the ultrasonic vibration. Therefore, when the object to be collected is discharged from the remover together with the stripping liquid, the object to be collected can be collected and collected in the collector.

The injector may include a switching valve that switches between the stripping solution and the cleaning solution to be injected into the remover. After the collection target is peeled from the remover with the stripping liquid, the cleaning liquid can be flowed from the injector by switching the switching valve, so the collection target that cannot be completely peeled off by the stripping liquid is peeled off with the cleaning liquid. Can be shed.

According to the blood treatment apparatus of the present invention, since the fine bubbles adsorbed on the object to be removed are taken into the micropores of the porous hollow fiber, it is difficult for the object to be removed to obstruct the blood flow through the porous hollow fiber. Since the porous hollow fiber does not coagulate or is difficult to coagulate, it is possible to make it difficult for the object to be removed to obstruct the blood flow passing through the porous hollow fiber. Therefore, the blood treatment device of the present invention can purify the blood by the remover and can suppress the deterioration of the blood flow by the remover.
Further, since the object to be removed removed from the blood by the blood-containing substance collecting device of the present invention can be collected and inspected as the object to be collected, it is possible to detect a wide variety of diseases at an early stage with high accuracy. it can. In addition, the therapeutic effect can be diagnosed during treatment.

It is a figure for demonstrating the structure of the blood processing apparatus which concerns on embodiment of this invention. It is a figure for demonstrating the structure of the microbubble water generation apparatus of the blood processing apparatus shown in FIG. It is a figure for demonstrating the remover of the blood processing apparatus shown in FIG. 1, (A) is the figure for demonstrating the inside of the remover, and (B) is a partial enlargement for demonstrating the operation of the remover. It is a figure. It is a figure for demonstrating the structure of the blood-containing substance collecting apparatus which concerns on embodiment of this invention.

The blood processing apparatus according to the embodiment of the present invention will be described with reference to the drawings.
The blood treatment apparatus 10 shown in FIG. 1 is capable of removing a substance including a causative substance from blood as a removal target and returning the blood.
The blood treatment device 10 mixes the fine bubble water generator 20 that generates fine bubble water, the blood circuit C that is a conduit through which the blood collected from the patient is returned to the patient, and the fine bubble water in the blood circuit C. A mixer 30 for removing an object to be removed contained in blood, a removing device 40 for removing an object to be removed, and a charging device 50 for applying a potential to the removing device 40 are provided.
Further, the blood processing device 10 includes a blood pump 61 that pumps blood from the blood circuit C, and an arterial pressure monitor 62 that measures the blood pressure of the blood circuit C on the downstream side of the blood pump 61.
Further, the blood treatment device 10 includes a replacement fluid supply device 70 on the downstream side of the remover 40 of the blood circuit C.

Here, the fine bubble water generator 20 will be described with reference to FIG.
In FIG. 2, check valves are provided at various points in the piping, but the description thereof will be omitted for convenience.
The fine bubble water generator 20 is a device that refines a gas charged with a negative potential and mixes it with water used as raw water. The gas can be hydrogen gas from the hydrogen tank T1.
The fine bubble water generator 20 includes a moving tank T2 for storing water which is raw water. The moving tank T2 is connected to the strongly electrolyzed water generator 21 via the two-way automatic valves V1 and V2.

The acidic side (anode side) of the strongly electrolyzed water generator 21 is stored because it is not used in the blood treatment device 10 (see FIG. 1). The alkaline side (cathode side) of the strongly electrolyzed water generator 21 is connected to the alkaline ion storage tank T3. The alkaline ion storage tank T3 has a function of storing 5 L of strongly alkaline electrolyzed water.
Air pressure is supplied to the alkaline ion storage tank T3 in order to push out strongly alkaline electrolyzed water.

Each of the alkaline ion storage tanks T3 is connected to the fine bubble mixer 22 via an automatic valve V3.
The fine bubble mixer 22 includes a first mixer 221, a turbo mixer 222, and a second mixer 223, and a hydrogen tank T1 is connected to each of them via a three-way automatic valve V4.
ing.

The fine bubble mixer 22 is connected to the alkali supply tank T4 via a three-way automatic valve V5.
The alkali supply tank T4 is connected to the mixer 30 shown in FIG. 1 via a connector (not shown).

The remover 40 shown in FIG. 1 includes a hollow tubular portion 41 and a porous hollow fiber 42 arranged inside the tubular portion 41.
The tubular portion 41 is connected to the blood circuit C, and an injection port 41a (see FIG. 3A) into which blood from the blood circuit C is injected is formed on one end side, is connected to the blood circuit C, and is connected from the inside. A discharge port 41b for discharging the blood of the blood to the blood circuit C is formed on the other end side.
The porous hollow fiber 42 has openings formed at both ends, blood from the injection port 41a of the tubular portion 41 flows into one end, and blood from the other end of the porous hollow fiber 42 flows out to the discharge port 41b. As described above, it is connected to the tubular portion 41.
As the porous hollow fiber 42, the hollow fiber used in the hemodialysis filter can be used. The porous hollow fiber 42 is formed of, for example, polysulfone, polyvinylpyrrolidone (PVP), or the like.

As shown in FIG. 3B, the sealing layer 43 is formed on the outer peripheral surface of the porous hollow fiber 42, so that the micropores 42a of the porous hollow fiber 42 are closed.
The sealing layer 43 contains cellulose nanofibers 43a as a sealing material, and also contains a charged body (not shown) charged by the charging device 50 shown in FIG. In the present embodiment, the charged body is formed of glass powder.
The sealing layer 43 is formed by applying a viscous liquid (gel-like) cellulose nanofiber in which glass powder is dispersed to a porous hollow thread 42 and then drying the sealing layer 43.

The charging device 50 shown in FIG. 1 is an electrostatic generating device that generates static electricity to charge an insulating charged body to a positive potential or a negative potential by dielectric polarization. For example, the static electricity generator generates a negative potential in order to charge the charged body of the sealing layer 43 shown in FIG. 3B to a positive potential.

The replacement fluid supply device 70 shown in FIG. 1 pumps 72 to replenish the replacement fluid 71, which is a liquid for replenishment, in order to replenish a part of the object to be removed removed from the blood by the remover 40.

The operation and usage of the blood treatment apparatus 10 according to the embodiment of the present invention configured as described above will be described with reference to the drawings.
A case where fine bubbles of hydrogen gas are mixed with the acidic water generated on the anode side of the strongly electrolyzed water generator 21 shown in FIG. 2 will be described.

First, tap water, which is raw water, is supplied from the mobile tank T2 to the strong electrolyzed water generator 21. An appropriate amount of sodium chloride is added to the raw water to promote the production of electrolyzed water.
The acidic water generated on the anode side of the strongly electrolyzed water generator 21 can be used as a disinfectant.

The alkaline water generated on the cathode side of the strongly electrolyzed water generator 21 is stored in the alkaline ion storage tank T3. The alkaline water from the alkaline ion storage tank T3 is pumped to the fine bubble mixer 22 via the automatic valve V3.
When the alkaline water is pumped to the fine bubble mixer 22, the hydrogen gas from the hydrogen tank T1 becomes fine bubbles and is mixed with the alkaline water, and becomes alkaline hydrogen bubble water by the first mixer 221 of the fine bubble mixer 22. , The turbo mixer 222 turns into alkaline hydrogen fine bubble water, passes through the second mixer 223, and returns to the alkaline ion storage tank T3 via the three-way automatic valve V5.
By repeating such circulation in the alkaline hydrogen fine bubble water stored in the alkaline ion storage tank T3, the bubbles are further refined and the concentration of hydrogen gas is increased.
Then, the alkaline hydrogen fine bubble water in which the bubbles are refined and the hydrogen gas concentration is increased is sent to the alkaline supply tank T4 via the three-way automatic valve V5 and stored.

When alkaline hydrogen fine bubble water (which may be simply referred to as fine bubble water) is generated in this way, it is charged into the blood circuit C shown in FIG. 1 via the mixer 30.

The blood mixed with alkaline hydrogen fine bubble water via the mixer 30 is pumped by the blood pump 61, passes through the arterial pressure monitor 62, and flows into the remover 40.
In the remover 40, the glass powder, which is a charged body, is charged to a positive potential by the charging device 50. On the other hand, it is known that the fine bubbles contained in the alkaline hydrogen fine bubble water take on a negative potential by becoming fine bubbles.
Therefore, as shown in FIG. 3B, the fine bubbles B charged with a negative potential adsorb the waste products having a positive potential, the plaque fragments exfoliated from the blood vessel wall, and the objects to be removed such as corsterol oxide. Can be captured.

In this way, the fine bubbles B that have adsorbed and taken in waste products, plaque fragments, and corsterol oxide flow from the blood circuit C to the remover 40, and when they pass through the porous hollow fiber 42, they are flowed by the bloodstream. However, it is attracted to the sealing layer 43 on the outer peripheral surface of the porous hollow fiber 42, which has a positive potential, and is taken into the fine pores 42a of the porous hollow fiber 42.

Therefore, waste products, plaque fragments, oxidized corsterol, and the like can be removed from the blood, so that the blood can be purified.
Further, since the porous hollow fiber 42 used in the hemodialysis filter does not coagulate blood or is difficult to coagulate, it is difficult to obstruct the blood flow through which the object to be removed passes through the porous hollow fiber 42. Therefore, the blood can be purified by the remover 40, and the deterioration of blood flow in the remover 40 can be suppressed.

Since the charged body is made of glass powder, it can be charged to a positive potential, so that the fine bubbles B on which the object to be removed is adsorbed can be attracted to the sealing layer 43.
Further, since the cellulose nanofibers used as the main material of the sealing material of the sealing layer 43 are naturally derived, they do not adversely affect blood. Therefore, the cellulose nanofibers can be used as a sealing material with peace of mind.

Then, the blood from which waste products, plaque fragments, and oxidized corsterol have been removed is discharged from the remover 40, flows through the blood circuit C, and flows into the replacement fluid supply device 70.
In the remover 40, waste products, plaque fragments exfoliated from the blood vessel wall, and corsterol oxide are adsorbed by microbubbles charged with a negative potential, but essential components such as essential amino acids, vitamins, proteins, etc., which are necessary for the body, are adsorbed. The active ingredient is also adsorbed by the microbubbles and removed from the blood. In the replacement fluid supply device 70, one or both of the essential component and the active ingredient are replenished to the blood.
Then, the blood flows from the replacement fluid supply device 70 to the blood circuit C and is returned to the patient. Therefore, the essential components and useful components removed from the blood by the replacement fluid supply device 70 are replenished, so that only unnecessary objects to be removed are removed. It can be returned to the patient in the removed state.

Next, the blood-containing substance collecting device according to the embodiment of the present invention will be described with reference to the drawings.
The blood-containing substance collecting device 100 shown in FIG. 4 removes the remover 40 from the blood processing device 10 shown in FIG. 1 in order to inspect the patient's blood, and the blood component contained in the patient's blood adsorbed on the remover 40. It is for collecting blood.

The blood-containing substance collecting device 100 applies vibration to the injector 110 for injecting a stripping solution that peels off the object to be removed adhering to the inner wall of the porous hollow fiber of the remover 40 as the object to be collected, and the remover 40. It includes an ultrasonic vibration generator 120 and a collector 130 that collects an object to be collected from the remover 40.

The injector 110 includes a first bag 111 in which the stripping solution A is stored, a second bag 112 in which the cleaning water B is stored, and a stripping solution from the first bag 111 or a second bag 112. It is provided with a switching valve 113 for selecting one of the cleaning liquids from the above, and a stand 114 for suspending the first bag 111 and the second bag 112.

The ultrasonic vibration generator 120 includes an ultrasonic vibrator 122 having a clamp portion 121 for gripping the remover 40, and an ultrasonic vibration controller 123 for controlling the ultrasonic vibrator 122.

The operation and usage state of the blood-containing substance collecting device 100 according to the embodiment of the present invention configured as described above will be described with reference to the drawings.
First, the operator removes the remover 40 from the blood treatment device 10 shown in FIG. 1, attaches it to the clamp portion 121 of the ultrasonic vibrator 122 in the blood-containing substance collecting device 100 shown in FIG. 4, and fixes it.

Next, the operator operates the ultrasonic vibration controller 123 to apply the ultrasonic vibration generated by the ultrasonic vibrator 122 to the remover 40. Next, the operator switches the switching valve 113 to the release liquid side to allow water to flow.
Then, the stripping liquid flowing through the remover 40 pulls the object to be collected taken into the fine pores 42a of the porous hollow fiber 42 shown in FIG. 3B from the porous hollow fiber 42 and the sealing layer 43. Peel off.
Further, since the ultrasonic vibration generated by the ultrasonic vibrator 122 is applied to the remover 40, it is possible to promote the peeling of the object to be collected adsorbed on the remover 40 by the ultrasonic vibration.

The object to be collected that has been peeled off from the porous hollow fiber 42 of the remover 40 is discharged from the remover 40 together with the release liquid and stored in the collector 130.

In the blood treatment apparatus 10 shown in FIG. 1, the remover 40 charged with static electricity having a positive potential is a substance containing a pathogenic substance by mixing hydrogen fine bubbles charged with a negative potential into blood taken out of the human body. It is in a state where (collection target) is adsorbed. Therefore, by collecting the substance containing the pathogenic substance from the remover 40 with the blood-containing substance collecting device 100, it is possible to analyze the substance containing the pathogenic substance adsorbed on the porous hollow thread 42. Various diseases can be detected at an early stage with high accuracy. In addition, the therapeutic effect can be diagnosed during treatment.

When the collection of the object to be collected from the remover 40 is completed, the operator switches the switching valve 113 to the side of the second bag 112 in which the cleaning liquid such as physiological saline is stored. By doing so, the cleaning liquid flows from the second bag 112 and flows in the remover 40, so that the collected object that cannot be completely peeled off by the peeling liquid can be peeled off by the cleaning liquid and flowed. It is desirable to apply the ultrasonic vibration generated by the ultrasonic vibrator 122 to the remover 40 while the cleaning liquid is flowing.
After the peeling treatment for flowing the stripping liquid from the first bag 111 is performed, the cleaning treatment for flowing the cleaning liquid from the second bag 112 is performed to complete one collection of the object to be removed, but if necessary. You may go several times.

The present invention is an optimal device that can obtain a therapeutic effect in a hospital and can be expected to be detected early by inspection at a hospital, university, research institution, or the like.

10 Blood treatment device 20 Fine bubble water generator 21 Strong electrolytic water generator 22 Fine bubble mixer 221 First mixer 222 Turbo mixer 223 Second mixer 30 Mixer 40 Remover 41 Cylindrical part 41a Injection port 41b Outlet 42 Porous hollow thread 42a Micropores 43 Sealing layer 43a Cellulose nanofiber 50 Charging device 61 Blood pump 62 Arterial pressure monitor 70 Supplementary solution supply device 71 Supplementary solution 72 Pump 100 Blood-containing substance sampling device 110 Injector 111 First bag 112 Second Bag 113 Switching valve 114 Stand 120 Ultrasonic vibration generator 121 Clamp part 122 Ultrasonic vibrator 123 Ultrasonic vibration controller 130 Collector B Fine bubbles C Blood circuit T1 Hydrogen tank T2 Movement tank T3 Alkaline ion storage tank T4 Alkaline supply Tank V1, V2 2-way automatic valve V3 automatic valve V4, V5 3-way automatic valve

Claims (6)

The blood circuit, which is the conduit through which the blood collected from the patient is returned to the patient,
With the mixer interposed in the blood circuit,
A fine bubble water generator that generates fine bubble water containing fine bubbles that are mixed through the mixer and that are charged to a negative potential.
A remover that removes the object to be removed contained in the blood mixed by the mixer, and a remover.
The remover is provided with a charging device that applies a positive potential.
The remover is a blood treatment device including a porous hollow fiber in which a sealing layer containing a charged body charged by the charging device is formed on an outer peripheral surface and blood flows. The blood treatment apparatus according to claim 1, wherein the charged body is formed of glass powder. The blood treatment apparatus according to claim 1 or 2, wherein the sealing layer contains cellulose nanofibers as a sealing material. Any of claims 1 to 3, wherein the blood circuit is provided with a fluid replacement device for replenishing the necessary essential components and / and active ingredients in the body removed from the blood together with the object to be removed by the remover. The blood treatment apparatus according to the section. From the micropores, a removal target adhering to the fine pores of the inner wall of the porous hollow fiber of the remover removed from the blood treatment apparatus according to any one of claims 1 to 4 is used as a collection target. An injector that injects the peeling liquid to be peeled off, and
An ultrasonic vibration generator that applies vibration to the remover,
A blood-containing substance collecting device including a collecting device for collecting an object to be collected from the removing device. The blood-containing substance collecting device according to claim 5, wherein the injector is provided with a switching valve for switching between the stripping solution and the cleaning solution to be injected into the remover.

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