JP2020532323A5 - - Google Patents
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- JP2020532323A5 JP2020532323A5 JP2020534819A JP2020534819A JP2020532323A5 JP 2020532323 A5 JP2020532323 A5 JP 2020532323A5 JP 2020534819 A JP2020534819 A JP 2020534819A JP 2020534819 A JP2020534819 A JP 2020534819A JP 2020532323 A5 JP2020532323 A5 JP 2020532323A5
- Authority
- JP
- Japan
- Prior art keywords
- nascent
- antigen
- mhc
- cells
- allele
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023140746A JP7851893B2 (ja) | 2017-09-05 | 2023-08-31 | Ｔ細胞療法用の新生抗原の特定法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762554286P | 2017-09-05 | 2017-09-05 | |
| US62/554,286 | 2017-09-05 | ||
| US201762579734P | 2017-10-31 | 2017-10-31 | |
| US62/579,734 | 2017-10-31 | ||
| US201862644191P | 2018-03-16 | 2018-03-16 | |
| US62/644,191 | 2018-03-16 | ||
| US201862703197P | 2018-07-25 | 2018-07-25 | |
| US62/703,197 | 2018-07-25 | ||
| PCT/US2018/049614 WO2019050994A1 (en) | 2017-09-05 | 2018-09-05 | IDENTIFICATION OF NEOANTIGEN FOR LYMPHOCYTE THERAPY T |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023140746A Division JP7851893B2 (ja) | 2017-09-05 | 2023-08-31 | Ｔ細胞療法用の新生抗原の特定法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020532323A JP2020532323A (ja) | 2020-11-12 |
| JP2020532323A5 true JP2020532323A5 (https=) | 2021-10-07 |
| JP7763588B2 JP7763588B2 (ja) | 2025-11-04 |
Family
ID=65635144
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020534819A Active JP7763588B2 (ja) | 2017-09-05 | 2018-09-05 | Ｔ細胞療法用の新生抗原の特定法 |
| JP2023140746A Active JP7851893B2 (ja) | 2017-09-05 | 2023-08-31 | Ｔ細胞療法用の新生抗原の特定法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023140746A Active JP7851893B2 (ja) | 2017-09-05 | 2023-08-31 | Ｔ細胞療法用の新生抗原の特定法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20200363414A1 (https=) |
| EP (1) | EP3679578A4 (https=) |
| JP (2) | JP7763588B2 (https=) |
| KR (1) | KR102946326B1 (https=) |
| CN (1) | CN111315390A (https=) |
| AU (2) | AU2018328220C1 (https=) |
| CA (1) | CA3073812A1 (https=) |
| IL (1) | IL273030B2 (https=) |
| TW (1) | TW201920686A (https=) |
| WO (1) | WO2019050994A1 (https=) |
| ZA (1) | ZA202001531B (https=) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
| WO2016128060A1 (en) | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
| ES2970865T3 (es) | 2015-12-16 | 2024-05-31 | Gritstone Bio Inc | Identificación, fabricación y uso de neoantígenos |
| WO2017194170A1 (en) | 2016-05-13 | 2017-11-16 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of proteins or protein fragments for immunotherapy |
| US12440578B2 (en) | 2017-02-22 | 2025-10-14 | Io Biosciences, Inc. | Nucleic acid constructs comprising gene editing multi-sites and uses thereof |
| US10828330B2 (en) | 2017-02-22 | 2020-11-10 | IO Bioscience, Inc. | Nucleic acid constructs comprising gene editing multi-sites and uses thereof |
| WO2018224166A1 (en) | 2017-06-09 | 2018-12-13 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy |
| US20200363414A1 (en) * | 2017-09-05 | 2020-11-19 | Gritstone Oncology, Inc. | Neoantigen Identification for T-Cell Therapy |
| EP4576103A3 (en) | 2017-10-10 | 2025-08-27 | Gritstone bio, Inc. | Neoantigen identification using hotspots |
| CN111630602A (zh) | 2017-11-22 | 2020-09-04 | 磨石肿瘤生物技术公司 | 减少新抗原的接合表位呈递 |
| US11730387B2 (en) * | 2018-11-02 | 2023-08-22 | University Of Central Florida Research Foundation, Inc. | Method for detection and diagnosis of lung and pancreatic cancers from imaging scans |
| US11599774B2 (en) * | 2019-03-29 | 2023-03-07 | International Business Machines Corporation | Training machine learning model |
| WO2020210591A1 (en) * | 2019-04-11 | 2020-10-15 | Google Llc | Predicting biological functions of proteins using dilated convolutional neural networks |
| CN110298036B (zh) * | 2019-06-06 | 2022-07-22 | 昆明理工大学 | 一种基于词性增量迭代的在线医疗文本症状识别方法 |
| WO2020263919A1 (en) * | 2019-06-24 | 2020-12-30 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | A peptide-based screening method to identify neoantigens for use with tumor infiltrating lymphocytes |
| KR20240137107A (ko) | 2019-07-16 | 2024-09-19 | 길리애드 사이언시즈, 인코포레이티드 | Hiv 백신, 및 이의 제조 및 사용 방법 |
| JP2022543583A (ja) * | 2019-07-30 | 2022-10-13 | ブレイクバイオ コーポレイション | 固形腫瘍の治療方法 |
| CN110277135B (zh) * | 2019-08-10 | 2021-06-01 | 杭州新范式生物医药科技有限公司 | 一种基于预期疗效选择个体化肿瘤新抗原的方法和系统 |
| CN110514845B (zh) * | 2019-08-22 | 2022-09-27 | 深圳新合睿恩生物医疗科技有限公司 | 一种肿瘤新生抗原免疫原性检测方法及检测平台 |
| CN110534156B (zh) * | 2019-09-02 | 2022-06-17 | 深圳市新合生物医疗科技有限公司 | 一种提取免疫治疗新抗原的方法及系统 |
| WO2021048400A1 (en) * | 2019-09-13 | 2021-03-18 | Evaxion Biotech Aps | Method for identifying t-cell epitopes |
| IL291935A (en) * | 2019-10-08 | 2022-06-01 | Pact Pharma Inc | Methods for immunotherapy of genetically modified autologous t cells |
| KR102184720B1 (ko) * | 2019-10-11 | 2020-11-30 | 한국과학기술원 | 암 세포 표면의 mhc-펩타이드 결합도 예측 방법 및 분석 장치 |
| WO2021091541A1 (en) * | 2019-11-05 | 2021-05-14 | Kri Technologies Incorporated | Identifying cancer neoantigens for personalized cancer immunotherapy |
| GB202003669D0 (en) * | 2020-03-13 | 2020-04-29 | Univ Oxford Innovation Ltd | Method for identifying neo-antigens |
| CN113469400B (zh) * | 2020-03-31 | 2025-03-18 | 北京沃东天骏信息技术有限公司 | 补货方法及装置、电子设备、存储介质 |
| CN111599410B (zh) * | 2020-05-20 | 2023-06-13 | 深圳市新合生物医疗科技有限公司 | 一种整合多组学数据提取微卫星不稳定免疫治疗新抗原的方法和应用 |
| CN111709867B (zh) * | 2020-06-10 | 2022-11-25 | 四川大学 | 基于新型全卷积网络的等模矢量分解图像加密分析方法 |
| AU2021320556A1 (en) | 2020-08-07 | 2023-03-09 | Neogene Therapeutics B.V. | Methods to enrich genetically engineered T cells |
| WO2022059780A1 (ja) * | 2020-09-18 | 2022-03-24 | サイアス株式会社 | ｉＰＳ細胞を介する再生Ｔ細胞の製造方法 |
| CN112086129B (zh) * | 2020-09-23 | 2021-04-06 | 深圳吉因加医学检验实验室 | 预测肿瘤组织cfDNA的方法及系统 |
| CN116802738A (zh) * | 2020-11-06 | 2023-09-22 | 亚马逊科技公司 | 为个体化癌症疫苗选择新抗原 |
| JP7451378B2 (ja) * | 2020-11-06 | 2024-03-18 | 株式会社東芝 | 情報処理装置 |
| US20230420077A1 (en) * | 2020-11-18 | 2023-12-28 | Kiromic BioPharma, Inc. | Disease-associated isoform identifier |
| US12053517B2 (en) | 2021-01-14 | 2024-08-06 | Gilead Sciences, Inc. | HIV vaccines and methods of using |
| WO2022170067A1 (en) * | 2021-02-05 | 2022-08-11 | Amazon Technologies, Inc. | Ranking neoantigens for personalized cancer vaccine |
| CN113106062A (zh) * | 2021-04-12 | 2021-07-13 | 赜誉(上海)生物科技有限公司 | 一种肿瘤新生抗原特异性肿瘤浸润淋巴细胞共培养方法 |
| JP7619443B2 (ja) * | 2021-04-20 | 2025-01-22 | 富士通株式会社 | 情報処理プログラム、情報処理方法および情報処理装置 |
| CN113160887B (zh) * | 2021-04-23 | 2022-06-14 | 哈尔滨工业大学 | 一种融合了单细胞tcr测序数据的肿瘤新生抗原筛选方法 |
| WO2022229966A1 (en) | 2021-04-29 | 2022-11-03 | Yeda Research And Development Co. Ltd. | T cell receptors directed against ras-derived recurrent neoantigens and methods of identifying same |
| US20220383996A1 (en) * | 2021-05-27 | 2022-12-01 | Amazon Technologies, Inc. | Assigning peptides to peptide groups for vaccine development |
| US12537072B1 (en) | 2021-05-27 | 2026-01-27 | Amazon Technologies, Inc. | Immunogenic response prediction based on major histocompatibility complex (MHC) data |
| WO2023077113A1 (en) | 2021-10-29 | 2023-05-04 | Immunoracle Inc. | Methods of analyzing a sample for cancer-specific immune cells |
| CN114420200A (zh) * | 2022-01-19 | 2022-04-29 | 时代生物科技（深圳）有限公司 | 一种功能性肽的筛选方法 |
| CN114649094B (zh) * | 2022-03-30 | 2022-11-15 | 广东省人民医院 | 一种基于核磁共振的乳腺癌多参数临床决策辅助装置 |
| EP4519675A4 (en) * | 2022-05-03 | 2026-04-08 | 3T Biosciences Inc | T-LYMPHOCYTE TARGET DISCOVERY |
| CN115497564A (zh) * | 2022-09-01 | 2022-12-20 | 北京航空航天大学 | 一种鉴定抗原模型建立方法及鉴定抗原方法 |
| GB202216453D0 (en) * | 2022-11-04 | 2022-12-21 | Lisziewicz Julianna | Identification of antigens which induce t-cell responses |
| CN116469473B (zh) * | 2023-06-15 | 2023-09-22 | 北京智因东方转化医学研究中心有限公司 | T细胞亚型鉴定的模型训练方法、装置、设备及存储介质 |
| IL326727A (en) * | 2023-08-23 | 2026-04-01 | Lg Chemical Ltd | A method for neoantigen selection for personalized cancer vaccine development |
| CN117316273B (zh) * | 2023-11-02 | 2024-09-06 | 聊城市人民医院 | 基于图神经网络的肿瘤个体化新抗原多肽筛选方法及装置 |
| CN117743957B (zh) * | 2024-02-06 | 2024-05-07 | 北京大学第三医院（北京大学第三临床医学院） | 一种基于机器学习的Th2A细胞的数据分选方法及相关设备 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1272636B8 (en) * | 2000-04-04 | 2008-10-08 | University Of Rochester | A gene differentially expressed in breast and bladder cancer and encoded polypeptides |
| DK2352756T3 (da) * | 2008-11-24 | 2012-12-03 | Helmholtz Zentrum Muenchen | Højaffin T-cellereceptor og anvendelse af denne |
| WO2014012051A1 (en) * | 2012-07-12 | 2014-01-16 | Persimmune, Inc. | Personalized cancer vaccines and adoptive immune cell therapies |
| EP2983702A2 (en) * | 2013-04-07 | 2016-02-17 | The Broad Institute, Inc. | Compositions and methods for personalized neoplasia vaccines |
| WO2014180490A1 (en) * | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
| KR101503341B1 (ko) * | 2014-03-12 | 2015-03-18 | 국립암센터 | 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법 |
| US20150278441A1 (en) * | 2014-03-25 | 2015-10-01 | Nec Laboratories America, Inc. | High-order semi-Restricted Boltzmann Machines and Deep Models for accurate peptide-MHC binding prediction |
| CA3017170C (en) * | 2014-09-17 | 2021-03-23 | The Johns Hopkins University | Reagents and methods for identifying, enriching, and/or expanding antigen-specific t cells |
| US10975442B2 (en) * | 2014-12-19 | 2021-04-13 | Massachusetts Institute Of Technology | Molecular biomarkers for cancer immunotherapy |
| WO2016145578A1 (en) * | 2015-03-13 | 2016-09-22 | Syz Cell Therapy Co. | Methods of cancer treatment using activated t cells |
| IL294183B2 (en) * | 2015-05-20 | 2023-10-01 | Dana Farber Cancer Inst Inc | shared neoantigens |
| ES2970865T3 (es) * | 2015-12-16 | 2024-05-31 | Gritstone Bio Inc | Identificación, fabricación y uso de neoantígenos |
| US11965892B2 (en) * | 2017-02-12 | 2024-04-23 | Biontech Us Inc. | HLA-based methods and compositions and uses thereof |
| US20200363414A1 (en) | 2017-09-05 | 2020-11-19 | Gritstone Oncology, Inc. | Neoantigen Identification for T-Cell Therapy |
-
2018
- 2018-09-05 US US16/644,934 patent/US20200363414A1/en not_active Abandoned
- 2018-09-05 CN CN201880071563.6A patent/CN111315390A/zh active Pending
- 2018-09-05 JP JP2020534819A patent/JP7763588B2/ja active Active
- 2018-09-05 AU AU2018328220A patent/AU2018328220C1/en active Active
- 2018-09-05 IL IL273030A patent/IL273030B2/en unknown
- 2018-09-05 CA CA3073812A patent/CA3073812A1/en active Pending
- 2018-09-05 KR KR1020207009649A patent/KR102946326B1/ko active Active
- 2018-09-05 WO PCT/US2018/049614 patent/WO2019050994A1/en not_active Ceased
- 2018-09-05 EP EP18854437.3A patent/EP3679578A4/en active Pending
- 2018-09-05 TW TW107131173A patent/TW201920686A/zh unknown
-
2020
- 2020-03-11 ZA ZA2020/01531A patent/ZA202001531B/en unknown
-
2023
- 2023-08-31 JP JP2023140746A patent/JP7851893B2/ja active Active
-
2025
- 2025-12-09 AU AU2025279629A patent/AU2025279629A1/en active Pending
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