JP2020532323A5 - - Google Patents
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- JP2020532323A5 JP2020532323A5 JP2020534819A JP2020534819A JP2020532323A5 JP 2020532323 A5 JP2020532323 A5 JP 2020532323A5 JP 2020534819 A JP2020534819 A JP 2020534819A JP 2020534819 A JP2020534819 A JP 2020534819A JP 2020532323 A5 JP2020532323 A5 JP 2020532323A5
- Authority
- JP
- Japan
- Prior art keywords
- nascent
- antigen
- mhc
- cells
- allele
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023140746A JP7851893B2 (ja) | 2017-09-05 | 2023-08-31 | Ｔ細胞療法用の新生抗原の特定法 |
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762554286P | 2017-09-05 | 2017-09-05 | |
| US62/554,286 | 2017-09-05 | ||
| US201762579734P | 2017-10-31 | 2017-10-31 | |
| US62/579,734 | 2017-10-31 | ||
| US201862644191P | 2018-03-16 | 2018-03-16 | |
| US62/644,191 | 2018-03-16 | ||
| US201862703197P | 2018-07-25 | 2018-07-25 | |
| US62/703,197 | 2018-07-25 | ||
| PCT/US2018/049614 WO2019050994A1 (en) | 2017-09-05 | 2018-09-05 | IDENTIFICATION OF NEOANTIGEN FOR LYMPHOCYTE THERAPY T |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023140746A Division JP7851893B2 (ja) | 2017-09-05 | 2023-08-31 | Ｔ細胞療法用の新生抗原の特定法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2020532323A JP2020532323A (ja) | 2020-11-12 |
| JP2020532323A5 true JP2020532323A5 (https=) | 2021-10-07 |
| JP7763588B2 JP7763588B2 (ja) | 2025-11-04 |
Family
ID=65635144
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020534819A Active JP7763588B2 (ja) | 2017-09-05 | 2018-09-05 | Ｔ細胞療法用の新生抗原の特定法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20200363414A1 (https=) |
| EP (1) | EP3679578A4 (https=) |
| JP (1) | JP7763588B2 (https=) |
| KR (1) | KR102946326B1 (https=) |
| CN (1) | CN111315390A (https=) |
| AU (2) | AU2018328220C1 (https=) |
| CA (1) | CA3073812A1 (https=) |
| IL (1) | IL273030B2 (https=) |
| TW (1) | TW201920686A (https=) |
| WO (1) | WO2019050994A1 (https=) |
| ZA (1) | ZA202001531B (https=) |
Families Citing this family (51)
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| WO2014180490A1 (en) | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
| WO2016128060A1 (en) | 2015-02-12 | 2016-08-18 | Biontech Ag | Predicting t cell epitopes useful for vaccination |
| RU2729116C2 (ru) | 2015-12-16 | 2020-08-04 | Гритстоун Онколоджи, Инк. | Идентификация, производство и применение неоантигенов |
| WO2017194170A1 (en) | 2016-05-13 | 2017-11-16 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of proteins or protein fragments for immunotherapy |
| US10828330B2 (en) | 2017-02-22 | 2020-11-10 | IO Bioscience, Inc. | Nucleic acid constructs comprising gene editing multi-sites and uses thereof |
| US12440578B2 (en) | 2017-02-22 | 2025-10-14 | Io Biosciences, Inc. | Nucleic acid constructs comprising gene editing multi-sites and uses thereof |
| WO2018224166A1 (en) | 2017-06-09 | 2018-12-13 | Biontech Rna Pharmaceuticals Gmbh | Methods for predicting the usefulness of disease specific amino acid modifications for immunotherapy |
| KR20260039788A (ko) | 2017-10-10 | 2026-03-20 | 시애틀 프로젝트 코포레이션 | 핫스팟을 이용한 신생항원 동정 |
| CA3083097A1 (en) | 2017-11-22 | 2019-05-31 | Gritstone Oncology, Inc. | Reducing junction epitope presentation for neoantigens |
| US11730387B2 (en) * | 2018-11-02 | 2023-08-22 | University Of Central Florida Research Foundation, Inc. | Method for detection and diagnosis of lung and pancreatic cancers from imaging scans |
| US11599774B2 (en) * | 2019-03-29 | 2023-03-07 | International Business Machines Corporation | Training machine learning model |
| EP3953939A1 (en) * | 2019-04-11 | 2022-02-16 | Google LLC | Predicting biological functions of proteins using dilated convolutional neural networks |
| CN110298036B (zh) * | 2019-06-06 | 2022-07-22 | 昆明理工大学 | 一种基于词性增量迭代的在线医疗文本症状识别方法 |
| CA3145196A1 (en) * | 2019-06-24 | 2020-12-30 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | A peptide-based screening method to identify neoantigens for use with tumor infiltrating lymphocytes |
| CN114761041A (zh) | 2019-07-16 | 2022-07-15 | 吉利德科学公司 | Hiv疫苗及其制备和使用方法 |
| US20220265792A1 (en) * | 2019-07-30 | 2022-08-25 | Breakbio Corp. | Methods for treating solid tumors |
| CN110277135B (zh) * | 2019-08-10 | 2021-06-01 | 杭州新范式生物医药科技有限公司 | 一种基于预期疗效选择个体化肿瘤新抗原的方法和系统 |
| CN110514845B (zh) * | 2019-08-22 | 2022-09-27 | 深圳新合睿恩生物医疗科技有限公司 | 一种肿瘤新生抗原免疫原性检测方法及检测平台 |
| CN110534156B (zh) * | 2019-09-02 | 2022-06-17 | 深圳市新合生物医疗科技有限公司 | 一种提取免疫治疗新抗原的方法及系统 |
| EP4028763A1 (en) * | 2019-09-13 | 2022-07-20 | Evaxion Biotech A/S | Method for identifying t-cell epitopes |
| CN114585385A (zh) * | 2019-10-08 | 2022-06-03 | 派克特制药公司 | 使用遗传修饰的自体t细胞免疫疗法的治疗方法 |
| KR102184720B1 (ko) * | 2019-10-11 | 2020-11-30 | 한국과학기술원 | 암 세포 표면의 mhc-펩타이드 결합도 예측 방법 및 분석 장치 |
| WO2021091541A1 (en) * | 2019-11-05 | 2021-05-14 | Kri Technologies Incorporated | Identifying cancer neoantigens for personalized cancer immunotherapy |
| GB202003669D0 (en) * | 2020-03-13 | 2020-04-29 | Univ Oxford Innovation Ltd | Method for identifying neo-antigens |
| CN113469400B (zh) * | 2020-03-31 | 2025-03-18 | 北京沃东天骏信息技术有限公司 | 补货方法及装置、电子设备、存储介质 |
| CN111599410B (zh) * | 2020-05-20 | 2023-06-13 | 深圳市新合生物医疗科技有限公司 | 一种整合多组学数据提取微卫星不稳定免疫治疗新抗原的方法和应用 |
| CN111709867B (zh) * | 2020-06-10 | 2022-11-25 | 四川大学 | 基于新型全卷积网络的等模矢量分解图像加密分析方法 |
| EP4192941A1 (en) | 2020-08-07 | 2023-06-14 | Neogene Therapeutics B.V. | Methods to enrich genetically engineered t cells |
| WO2022059780A1 (ja) * | 2020-09-18 | 2022-03-24 | サイアス株式会社 | ｉＰＳ細胞を介する再生Ｔ細胞の製造方法 |
| CN112086129B (zh) * | 2020-09-23 | 2021-04-06 | 深圳吉因加医学检验实验室 | 预测肿瘤组织cfDNA的方法及系统 |
| JP7451378B2 (ja) * | 2020-11-06 | 2024-03-18 | 株式会社東芝 | 情報処理装置 |
| US20230197192A1 (en) * | 2020-11-06 | 2023-06-22 | Amazon Technologies, Inc. | Selecting neoantigens for personalized cancer vaccine |
| EP4248368A4 (en) * | 2020-11-18 | 2024-12-18 | Kiromic BioPharma, Inc. | DISEASE-ASSOCIATED ISOFORM IDENTIFIER |
| EP4277652A1 (en) | 2021-01-14 | 2023-11-22 | Gilead Sciences, Inc. | Hiv vaccines and methods of using |
| JP2024508677A (ja) * | 2021-02-05 | 2024-02-28 | アマゾン テクノロジーズ インコーポレイテッド | 個別化がんワクチン用ネオアンチゲンのランク付け |
| CN113106062A (zh) * | 2021-04-12 | 2021-07-13 | 赜誉(上海)生物科技有限公司 | 一种肿瘤新生抗原特异性肿瘤浸润淋巴细胞共培养方法 |
| WO2022224336A1 (ja) * | 2021-04-20 | 2022-10-27 | 富士通株式会社 | 情報処理プログラム、情報処理方法および情報処理装置 |
| CN113160887B (zh) * | 2021-04-23 | 2022-06-14 | 哈尔滨工业大学 | 一种融合了单细胞tcr测序数据的肿瘤新生抗原筛选方法 |
| CA3216276A1 (en) | 2021-04-29 | 2022-11-03 | Yardena Samuels | T cell receptors directed against ras-derived recurrent neoantigens and methods of identifying same |
| US12537072B1 (en) | 2021-05-27 | 2026-01-27 | Amazon Technologies, Inc. | Immunogenic response prediction based on major histocompatibility complex (MHC) data |
| US20220383996A1 (en) * | 2021-05-27 | 2022-12-01 | Amazon Technologies, Inc. | Assigning peptides to peptide groups for vaccine development |
| WO2023077113A1 (en) | 2021-10-29 | 2023-05-04 | Immunoracle Inc. | Methods of analyzing a sample for cancer-specific immune cells |
| CN114420200A (zh) * | 2022-01-19 | 2022-04-29 | 时代生物科技（深圳）有限公司 | 一种功能性肽的筛选方法 |
| CN114649094B (zh) * | 2022-03-30 | 2022-11-15 | 广东省人民医院 | 一种基于核磁共振的乳腺癌多参数临床决策辅助装置 |
| WO2023215358A1 (en) * | 2022-05-03 | 2023-11-09 | 3T Biosciences, Inc. | T-cell target discovery |
| CN115497564A (zh) * | 2022-09-01 | 2022-12-20 | 北京航空航天大学 | 一种鉴定抗原模型建立方法及鉴定抗原方法 |
| GB202216453D0 (en) * | 2022-11-04 | 2022-12-21 | Lisziewicz Julianna | Identification of antigens which induce t-cell responses |
| CN116469473B (zh) * | 2023-06-15 | 2023-09-22 | 北京智因东方转化医学研究中心有限公司 | T细胞亚型鉴定的模型训练方法、装置、设备及存储介质 |
| IL326727A (en) * | 2023-08-23 | 2026-04-01 | Lg Chemical Ltd | A method for neoantigen selection for personalized cancer vaccine development |
| CN117316273B (zh) * | 2023-11-02 | 2024-09-06 | 聊城市人民医院 | 基于图神经网络的肿瘤个体化新抗原多肽筛选方法及装置 |
| CN117743957B (zh) * | 2024-02-06 | 2024-05-07 | 北京大学第三医院（北京大学第三临床医学院） | 一种基于机器学习的Th2A细胞的数据分选方法及相关设备 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7268207B2 (en) * | 2000-04-04 | 2007-09-11 | University Of Rochester | Gene differentially expressed in breast and bladder cancer, and encoded polypeptides |
| CN102272153B (zh) * | 2008-11-24 | 2015-04-15 | 德国慕尼黑亥姆霍兹研究中心健康和环境有限公司 | 高亲和力t细胞受体及其应用 |
| CA2879024A1 (en) * | 2012-07-12 | 2014-01-16 | Persimmune, Inc. | Personalized cancer vaccines and adoptive immune cell therapies |
| CN118750591A (zh) * | 2013-04-07 | 2024-10-11 | 博德研究所 | 用于个性化瘤形成疫苗的组合物和方法 |
| WO2014180490A1 (en) * | 2013-05-10 | 2014-11-13 | Biontech Ag | Predicting immunogenicity of t cell epitopes |
| KR101503341B1 (ko) * | 2014-03-12 | 2015-03-18 | 국립암센터 | 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법 |
| US20150278441A1 (en) * | 2014-03-25 | 2015-10-01 | Nec Laboratories America, Inc. | High-order semi-Restricted Boltzmann Machines and Deep Models for accurate peptide-MHC binding prediction |
| CN107002038B (zh) * | 2014-09-17 | 2021-10-15 | 约翰·霍普金斯大学 | 用于识别、富集和/或扩增抗原特异性t细胞的试剂和方法 |
| US10975442B2 (en) * | 2014-12-19 | 2021-04-13 | Massachusetts Institute Of Technology | Molecular biomarkers for cancer immunotherapy |
| WO2016145578A1 (en) * | 2015-03-13 | 2016-09-22 | Syz Cell Therapy Co. | Methods of cancer treatment using activated t cells |
| TW202523682A (zh) * | 2015-05-20 | 2025-06-16 | 美商博德研究所有限公司 | 共有之gata3相關之腫瘤特異性新抗原 |
| RU2729116C2 (ru) | 2015-12-16 | 2020-08-04 | Гритстоун Онколоджи, Инк. | Идентификация, производство и применение неоантигенов |
| WO2018148671A1 (en) * | 2017-02-12 | 2018-08-16 | Neon Therapeutics, Inc. | Hla-based methods and compositions and uses thereof |
-
2018
- 2018-09-05 JP JP2020534819A patent/JP7763588B2/ja active Active
- 2018-09-05 WO PCT/US2018/049614 patent/WO2019050994A1/en not_active Ceased
- 2018-09-05 EP EP18854437.3A patent/EP3679578A4/en active Pending
- 2018-09-05 CN CN201880071563.6A patent/CN111315390A/zh active Pending
- 2018-09-05 TW TW107131173A patent/TW201920686A/zh unknown
- 2018-09-05 KR KR1020207009649A patent/KR102946326B1/ko active Active
- 2018-09-05 AU AU2018328220A patent/AU2018328220C1/en active Active
- 2018-09-05 CA CA3073812A patent/CA3073812A1/en active Pending
- 2018-09-05 US US16/644,934 patent/US20200363414A1/en not_active Abandoned
- 2018-09-05 IL IL273030A patent/IL273030B2/en unknown
-
2020
- 2020-03-11 ZA ZA2020/01531A patent/ZA202001531B/en unknown
-
2025
- 2025-12-09 AU AU2025279629A patent/AU2025279629A1/en active Pending
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