JP2020502116A - 突然変異イソクエン酸デヒドロゲナーゼの阻害およびその組成物と方法 - Google Patents
突然変異イソクエン酸デヒドロゲナーゼの阻害およびその組成物と方法 Download PDFInfo
- Publication number
- JP2020502116A JP2020502116A JP2019531713A JP2019531713A JP2020502116A JP 2020502116 A JP2020502116 A JP 2020502116A JP 2019531713 A JP2019531713 A JP 2019531713A JP 2019531713 A JP2019531713 A JP 2019531713A JP 2020502116 A JP2020502116 A JP 2020502116A
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- JP
- Japan
- Prior art keywords
- compound
- mmol
- amino
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- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
- C07D491/048—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring the oxygen-containing ring being five-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662436328P | 2016-12-19 | 2016-12-19 | |
| US62/436,328 | 2016-12-19 | ||
| US201762536367P | 2017-07-24 | 2017-07-24 | |
| US62/536,367 | 2017-07-24 | ||
| PCT/US2017/067050 WO2018118793A1 (en) | 2016-12-19 | 2017-12-18 | Inhibitors of mutant isocitrate dehydrogenases and compositions and methods thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020502116A true JP2020502116A (ja) | 2020-01-23 |
| JP2020502116A5 JP2020502116A5 (OSRAM) | 2021-02-04 |
Family
ID=62627122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019531713A Pending JP2020502116A (ja) | 2016-12-19 | 2017-12-18 | 突然変異イソクエン酸デヒドロゲナーゼの阻害およびその組成物と方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11149032B2 (OSRAM) |
| EP (1) | EP3555079A4 (OSRAM) |
| JP (1) | JP2020502116A (OSRAM) |
| KR (1) | KR20190092476A (OSRAM) |
| CN (1) | CN110291085B (OSRAM) |
| AU (1) | AU2017379796B2 (OSRAM) |
| CA (1) | CA3047136A1 (OSRAM) |
| WO (1) | WO2018118793A1 (OSRAM) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10696665B2 (en) * | 2016-06-06 | 2020-06-30 | Eli Lilly And Company | Mutant IDH1 inhibitors |
| WO2019213403A1 (en) | 2018-05-02 | 2019-11-07 | Kinnate Biopharma Inc. | Inhibitors of cyclin-dependent kinases |
| KR20210040368A (ko) * | 2018-06-29 | 2021-04-13 | 킨네이트 바이오파마 인크. | 사이클린 의존성 키나제의 억제제 |
| CN111825666B (zh) * | 2019-04-23 | 2024-03-08 | 上海仕谱生物科技有限公司 | 二聚或多聚体形式的突变型idh抑制剂 |
| US20230405135A1 (en) * | 2020-09-14 | 2023-12-21 | Totus Medicines Inc. | Therapeutic conjugates |
| CN120554346A (zh) * | 2024-02-28 | 2025-08-29 | 中国科学院上海药物研究所 | 一类噁唑酮取代的嘧啶胺化合物及其制备方法、药物组合物和用途 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014528951A (ja) * | 2011-09-27 | 2014-10-30 | ノバルティス アーゲー | 変異体ｉｄｈの阻害剤としての３−ピリミジン−４−イル−オキサゾリジン−２−オン類 |
| JP2019517579A (ja) * | 2016-06-06 | 2019-06-24 | イーライ リリー アンド カンパニー | 変異体ｉｄｈ１阻害剤 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2400447C (en) * | 2000-02-17 | 2008-04-22 | Amgen Inc. | Kinase inhibitors |
| AR064571A1 (es) * | 2006-12-28 | 2009-04-08 | Basf Ag | Pirimidinas sustituidas en posicion 2 por heterociclos nitrogenados, medicamentos y composiciones farmaceuticas que las contienen y usos de las mismas en el tratamiento del cancer. |
| AU2015317321B2 (en) * | 2014-09-19 | 2020-03-12 | Forma Therapeutics, Inc. | Quinolinone pyrimidines compositions as mutant-isocitrate dehydrogenase inhibitors |
| WO2017140758A1 (en) * | 2016-02-19 | 2017-08-24 | Debiopharm International S.A. | Derivatives of 2-amino-4-(2-oxazolidinon-3-yl)-pyrimidine fused with a five-membered heteroaromatic ring in 5,6-position which are useful for the treatment of various cancers |
-
2017
- 2017-12-18 AU AU2017379796A patent/AU2017379796B2/en not_active Ceased
- 2017-12-18 CA CA3047136A patent/CA3047136A1/en not_active Abandoned
- 2017-12-18 EP EP17882734.1A patent/EP3555079A4/en not_active Withdrawn
- 2017-12-18 US US16/467,978 patent/US11149032B2/en not_active Expired - Fee Related
- 2017-12-18 WO PCT/US2017/067050 patent/WO2018118793A1/en not_active Ceased
- 2017-12-18 CN CN201780086231.0A patent/CN110291085B/zh not_active Expired - Fee Related
- 2017-12-18 JP JP2019531713A patent/JP2020502116A/ja active Pending
- 2017-12-18 KR KR1020197019050A patent/KR20190092476A/ko not_active Abandoned
-
2021
- 2021-09-12 US US17/472,646 patent/US20210403460A1/en not_active Abandoned
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2014528951A (ja) * | 2011-09-27 | 2014-10-30 | ノバルティス アーゲー | 変異体ｉｄｈの阻害剤としての３−ピリミジン−４−イル−オキサゾリジン−２−オン類 |
| JP2019517579A (ja) * | 2016-06-06 | 2019-06-24 | イーライ リリー アンド カンパニー | 変異体ｉｄｈ１阻害剤 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3555079A1 (en) | 2019-10-23 |
| KR20190092476A (ko) | 2019-08-07 |
| CN110291085B (zh) | 2023-01-24 |
| AU2017379796A1 (en) | 2019-07-04 |
| WO2018118793A1 (en) | 2018-06-28 |
| CN110291085A (zh) | 2019-09-27 |
| US20210403460A1 (en) | 2021-12-30 |
| US20200071309A1 (en) | 2020-03-05 |
| EP3555079A4 (en) | 2020-08-19 |
| US11149032B2 (en) | 2021-10-19 |
| AU2017379796B2 (en) | 2021-10-21 |
| CA3047136A1 (en) | 2018-06-28 |
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| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
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