JP2020192291A - Chemical liquid supply device and blood purification system - Google Patents

Abstract

To provide a chemical liquid supply device and a blood purification system that are capable of performing adjustment so that a concentration of chemical liquid becomes a target concentration while inhibiting an amount of chemical liquid consumption from increasing even when retention liquid is detained.SOLUTION: A chemical liquid supply device 1 for supplying chemical liquid to a blood purification device for performing blood purification treatment comprises: a preparation unit 2 for mixing chemical liquid undiluted solution with clean water to prepare chemical liquid; and a control unit for performing control so that a concentration of the chemical liquid is adjusted to a stipulated concentration by supplying the chemical liquid undiluted solution having an amount corresponding to a residual amount of the clean water remaining in a pipeline via a circulation step of the clean water circulating in the pipeline, and supplying the chemical liquid to the blood purification device.SELECTED DRAWING: Figure 1

Description

The present invention relates to a drug solution supply device and a blood purification system.

In the central system (blood purification system) used for blood purification treatment, in order to disinfect the blood purification device that performs blood purification treatment, a drug solution supply device that prepares the drug solution used for disinfection and supplies it to the blood purification device is used. (See, for example, Patent Document 1).

Japanese Patent No. 5483741

The chemical solution supply device adjusts the concentration of the chemical solution to the desired value by diluting the chemical solution stock solution with clean water. However, when the water supply pressure of the clean water fluctuates depending on the operating environment or the like, the flow rate of the clean water supply fluctuates, which may affect the adjustment of the concentration.

Therefore, in the chemical solution supply device, clean water is supplied while measuring the supply flow rate with the water supply flow meter, and at the same time, the injection amount of the chemical solution stock solution determined based on the supply flow rate and the specified ratio of the clean water measured by the water supply flow meter is used as the stock solution. The drug solution is adjusted to the target concentration by a continuous dilution method in which the drug solution is continuously injected with an injection pump.

By the way, in the disinfection process for disinfecting the blood purification device, the inside of the pipe is emptied by draining the inside of the pipe after rinsing the chemical solution for cleaning used in the cleaning treatment performed before this with clean water. It is carried out through the distribution process.

However, when the disinfection treatment is started, a residual liquid of clean water that could not be completely drained in the distribution process may be left in the pipe as a retention liquid. In such a case, the chemical solution for disinfection is excessively diluted by the retained solution, so that the concentration of the chemical solution for disinfection may be lower than the target value adjusted by the continuous dilution method. ..

In this regard, for example, after the disinfection treatment is started, the chemical stock solution and clean water are injected by a continuous dilution method so as to exceed the storage capacity of the chemical solution supply device for a certain period of time, while the excess chemical solution is drained (overflow). ) Is known to adjust to the target concentration. In this method, since a necessary amount or more of the chemical stock solution is injected, even when the residual solution of clean water is indwelled, dilution by the residual solution can be suppressed and the target concentration can be adjusted. However, according to such a method, wasteful drainage of the chemical solution may increase the consumption of the chemical solution, which may lead to an increase in the cost of the chemical solution.

Therefore, according to the present invention, even when the clean water cannot be completely drained and is left in the pipe as a retained solution, the concentration of the chemical solution is adjusted to a target concentration while suppressing an increase in the consumption of the chemical solution. It is an object of the present invention to provide a drug solution supply device and a blood purification system capable of the above.

The drug solution supply device according to one embodiment of the present invention is a drug solution supply device that supplies a drug solution to a blood purification device that performs blood purification treatment, and includes a preparation unit that prepares a drug solution by mixing a drug solution stock solution and clean water. , The chemical solution stock solution is supplied in an amount corresponding to the residual amount of the clean water remaining in the pipe by the distribution process in which the clean water is distributed in the pipe, the chemical solution is adjusted to a specified concentration, and the blood is prepared. It includes a control unit that controls the supply to the purification device.

In addition, the blood purification system according to another embodiment of the present invention includes the above-mentioned chemical solution supply device and the blood purification device.

According to the present invention, even when the cleaning water cannot be completely drained and is left in the pipe as a retention solution, the concentration of the chemical solution can be adjusted to a target concentration while suppressing an increase in the consumption of the chemical solution. A drug solution supply device and a blood purification system can be provided.

It is a schematic block diagram which shows an example of the structure of the blood purification system which concerns on one Embodiment of this invention. It is a figure explaining an example of the operation of the disinfection process performed by the blood purification system shown in FIG. It is a figure explaining an example of the operation of the disinfection process performed in the blood purification system which concerns on a comparative example.

[Embodiment]
Hereinafter, embodiments of the present invention will be described with reference to the accompanying drawings. In this document, when the terms "chemical solution", "chemical solution stock solution" and "chemical solution supply device" are used, unless otherwise specified, the chemical solution for cleaning and the chemical solution for disinfection (hereinafter, "cleaning solution" and "disinfectant solution", respectively). In general, it includes not only "cleaning and disinfecting solution") but also chemicals for dialysis (hereinafter, also referred to as "dialysis solution").
(Blood purification system)
FIG. 1A is a schematic configuration diagram showing an example of the configuration of the blood purification system according to the present embodiment. As shown in FIG. 1A, the blood purification system 10 includes a drug solution supply device 1 according to the present embodiment and a plurality of blood purification devices 11 for performing blood purification treatment on a patient. The blood purification device 11 is, for example, a dialysis monitoring device (that is, a dialysis device). The drug solution supply device 1 is, for example, a dialysate supply device.

The chemical solution supply device 1 prepares a chemical solution having a predetermined concentration using the supplied clean water (for example, RO (Reverse Osmosis) water), and supplies the prepared chemical solution to each blood purification device 11. Further, the chemical solution supply device 1 prepares a chemical solution having a predetermined concentration using clean water, and supplies the prepared chemical solution to each blood purification device 11.

The chemical solution prepared by the chemical solution supply device 1 is supplied to each blood purification device 11 via the supply line 12. The details of the chemical solution supply device 1 will be described later.

A plurality of blood purifiers 11 are installed according to blood purifiers (dialyzers, not shown) for performing blood purification treatment on patients, and the drug solution supplied from the drug solution supply device 1 is supplied to each blood purifier. In each blood purification device 11, a washing step and a disinfecting step (hereinafter, also collectively referred to as "washing and disinfecting step" or simply "washing and erasing step") are carried out in this order using the supplied chemical solution. The chemical solution containing waste products discharged from the blood purifier is discharged into a drainage channel (not shown).

In the blood purification system 10 according to the present embodiment, the drug solution supply device 1 and each blood purification device 11 can communicate with each other via the signal line 13, and in the drug solution supply device 1, each blood purification device 11 It is possible to detect the operating status of. The communication mode between the drug solution supply device 1 and each blood purification device 11 is not limited to this, and may be wireless communication instead of wired communication, for example.

(Chemical solution supply device 1)
FIG. 1B is a schematic configuration diagram showing an example of the configuration of the chemical solution supply device 1 according to the present embodiment. As shown in FIG. 1 (b), the drug solution supply device 1 includes a preparation unit 2 for preparing the drug solution, a solution delivery unit 3 for delivering the prepared drug solution to the blood purification device 11, the preparation unit 2 and the solution delivery device 1. It mainly includes a control unit 8 for controlling the unit 3.

The preparation unit 2 prepares a chemical solution by mixing the chemical solution stock solution supplied from a predetermined supply source and clean water. Here, a case where two types of stock solutions A and B are used as the drug solution stock solution used for blood purification treatment will be described as an example. Further, as the chemical solution used for disinfecting the blood purification device 11, the case where one type is used will be described as an example, but the chemical solution for disinfection is not limited to one type and may be two or more types. The chemical solution for disinfection corresponds to, for example, a cleaning solution such as an acid cleaning solution, or a disinfecting solution such as a peracetic acid disinfectant or a hypochlorite disinfectant solution.

The preparation unit 2 opens and closes a liquid feeding line 21 in which clean water is supplied from one end and a chemical liquid flows, a water supply flow meter 22 provided in the liquid feeding line 21 for detecting the flow rate of clean water, and a liquid feeding line 21. The water supply valve 23 that can switch the supply or non-supply of clean water, the A stock solution injection pump 240 that injects the A stock solution from the A stock solution tank 4 that stores the A stock solution into the liquid supply line 21, and the B stock solution are stored. B undiluted solution injection pump 250 that injects B undiluted solution from B undiluted solution tank 5 into the feed line 21, and cleaning disinfectant undiluted solution injection pump that injects the chemical solution undiluted solution from the cleaning disinfectant undiluted solution tank 6 that stores the chemical solution undiluted solution into the undiluted solution line 21. It is provided with 260 and a liquid supply valve 261 capable of switching between the supply and non-supply of the chemical stock solution. The A stock solution tank 4, the B stock solution tank 5, and the cleaning disinfectant solution stock solution tank 6 are examples of predetermined supply sources. The liquid feeding line 21 is an example of piping.

Further, in the liquid feeding line 21, a liquid A stirring mechanism 241 for stirring the clean water and the liquid A is provided at a predetermined position after the undiluted solution A injected by the undiluted solution A injection pump 240 merges. Further, in the liquid feeding line 21, a liquid B stirring mechanism 251 for stirring the clean water and the liquid B is provided at a predetermined position after the undiluted solution B injected by the stock solution B injection pump 250 merges.

The water supply valve 23 and the liquid supply valve 261 are composed of solenoid valves, and are controlled to open and close by the control unit 8. The water supply valve 23 and the liquid supply valve 261 can be replaced with electric valves, respectively. As the A stock solution injection pump 240, the B stock solution injection pump 250, and the cleaning disinfectant solution stock solution injection pump 260, for example, a piston pump can be used. The A stock solution injection pump 240, the B stock solution injection pump 250, and the cleaning disinfectant solution stock solution injection pump 260 are controlled by the control unit 8 (see the broken line in FIG. 1 (b)).

The control unit 8 injects the chemical solution according to the supply amount of clean water detected by the water supply flow meter 22 (the discharge amounts of each of the A stock solution injection pump 240, the B stock solution injection pump 250, and the cleaning disinfectant solution stock solution injection pump 260). By controlling the above, a drug solution having a predetermined concentration is prepared. When the water supply valve 23 is closed, the supply amount of clean water detected by the water supply flow meter 22 becomes zero, and the injection amount of the A stock solution and the B stock solution becomes zero accordingly, and the preparation (or dilution of the chemical solution) of the chemical solution becomes zero. It will be stopped. That is, the control unit 8 controls the presence or absence of preparation of the chemical solution by opening and closing the water supply valve 23.

Further, the control unit 8 controls the opening and closing of the water supply valve 23 and the liquid supply valve 261 to inject the chemical solution stock solution from the cleaning disinfectant solution stock solution tank 6 into the liquid supply line 21. Specifically, the control unit 8 controls the injection amount of the chemical solution stock solution, and fills the liquid transfer line 21 with a predetermined amount of the chemical solution stock solution without supplying clean water. This process of filling a predetermined amount of the drug solution stock solution is performed prior to the preparation of the drug solution by the above-mentioned continuous dilution method (hereinafter, also referred to as "pre-filling"). That is, the control unit 8 controls the presence or absence of pre-filling by opening and closing the liquid supply valve 261.

The injection amount (that is, the predetermined amount) of the chemical solution stock solution injected into the liquid feeding line 21 is, for example, one step (pre-step) and another step (post-step) performed after this one step. If the chemicals used are different from each other, the amount of clean water remaining in the pipe (mainly in the liquid feeding line 21) for the clean water used in the step of washing away the chemicals performed after the completion of the previous step (mainly in the liquid feeding line 21). Hereinafter, it is also referred to as "residual amount"). The injection amount of the chemical solution stock solution may be determined based on the amount of clean water and the dilution ratio of the chemical solution stock solution and the clean water.

In FIG. 1B, the configuration in which the A stock solution tank 4, the B stock solution tank 5, and the cleaning disinfectant solution stock solution tank 6 are provided outside the preparation unit 2 is shown as an example, but the A stock solution tank 4 and The B undiluted solution tank 5 and the cleaning disinfectant undiluted solution tank 6 do not necessarily have to be provided outside the preparation unit 2, and may be provided, for example, inside the preparation unit 2.

The liquid feeding unit 3 has a storage tank 31 for storing the chemical liquid prepared by the preparation unit 2 and a liquid feeding pump 32 for feeding the chemical liquid in the storage tank 31. The end of the liquid feeding line 21 on the opposite side to the water supply side is connected to the storage tank 31, and the chemical liquid is supplied from the liquid feeding line 21.

Further, a supply line 12 for supplying a chemical solution to each blood purification device 11 is connected to the storage tank 31. The liquid feed pump 32 is provided on the supply line 12. The supply line 12 on the downstream side of the liquid feed pump 32 is provided with a liquid feed valve 33 capable of opening and closing the supply line 12. Further, the storage tank 31 is further provided with a first circulation line 34 having one end and the other end connected to the storage tank 31 and having a function of circulating a chemical solution. The control unit 8 controls the first circulation line 34 to circulate the chemical solution in order to make the concentration uniform.

Further, the storage tank 31 is further provided with an overflow line 36 connected to a drainage port (not shown) for draining the chemical solution stored inside. The drainage port is always open, but opening and closing may be controlled by the control unit 8.

Furthermore, the storage tank 31 and the liquid feed line 21 (for example, the position between the A stock solution tank 4 and the A stock solution injection pump 240, and the position between the B stock solution tank 5 and the B stock solution injection pump 250) are connected. , A second circulation line 35 (see symbol D in FIG. 1B) having a function of circulating the drug solution is further provided.

The liquid feed valve 33 includes an electric valve, and is controlled to open and close by the control unit 8. As the liquid feed pump 32, for example, a centrifugal pump can be used. The liquid feed pump 32 is controlled by the control unit 8. The liquid feed valve 33 can be replaced with a solenoid valve.

The control unit 8 is realized by appropriately combining arithmetic elements such as a CPU, a memory, a storage device, software, an interface, and the like. The control unit 8 controls various pumps and valves described above to execute various steps such as pre-filling, filling by a continuous dilution method (hereinafter, also simply referred to as “filling”), circulation, and liquid feeding.

(Operation of chemical supply device 1)
FIG. 2 is a diagram illustrating an example of the operation of the disinfection step performed by the blood purification system 10. The disinfection step 7 shown in FIG. 2 is performed after the cleaning step (not shown). Further, before the disinfection step 7 shown in FIG. 2, a process of washing away the cleaning liquid used in the cleaning step with clean water is performed by passing through a distribution step in which clean water flows through the pipe. Therefore, when the disinfection step 7 shown in FIG. 2 is started, a predetermined amount of clean water that could not be completely removed may remain in the pipe.

As shown in FIG. 2, the control unit 8 controls the liquid supply valve 261 to perform the pre-filling process 71 for filling the chemical solution stock solution from the cleaning disinfectant solution stock solution tank 6. As described above, the amount of the chemical stock solution to be filled in the pre-filling treatment 71 is predetermined according to the residual amount of clean water and the like. The residual amount of clean water is determined by theoretical values, measured values, empirical rules, etc., but may be determined by a method different from these methods. In the case of the theoretical value, for example, the pipe volume in which clean water is expected to remain may be calculated, and the amount of water according to the calculation result may be used as the residual amount of clean water. In the case of the measured value, the amount of water corresponding to the measured value previously measured by the measuring instrument may be the residual amount of clean water. The control unit 8 may perform the pre-filling process 71 according to a predetermined time.

After the pre-filling process 71 is completed, the control unit 8 performs the filling process 72 by the continuous dilution method. Next, the control unit 8 performs a circulation process 73 in which the chemical solution produced in the pre-filling process 71 and the filling process 72 is circulated in the first circulation line 34 for a certain period of time. Further, when the chemical as well as uniform concentrations of drug solution by circulating the chemical solution reaches the target concentration C _t, the control unit 8 stops the circulation process 73. The target concentration _Ct is an example of a specified concentration.

Whether chemical reaches the target concentration C _t may, for example, may be detected by measuring the concentration of the chemical by the density sensor (not shown). Alternatively, the execution time of the circulation process 73 may be set in advance according to the empirical rule or the like, the chemical liquid may be regarded to have reached the target concentration C _t when the execution time has elapsed from the start of the circulation process 73 .. In this case, the control unit 8 may control to stop the circulation process 73 when the duration of the circulation process 73, which is predetermined according to an empirical rule or the like, elapses.

Next, the control unit 8, the chemical solution is adjusted to the target concentration C _t is controlled to perform the feeding process 74 for feeding the blood purification device 11. In the blood purification device 11, the disinfection treatment 75 is executed using the chemical solution sent from the chemical solution supply device 1.

FIG. 3 is a diagram illustrating an example of the operation of the disinfection step performed in the blood purification system according to the comparative example. As shown in FIG. 3, in the blood purification system according to the comparative example, the pre-filling treatment 71 and the circulation treatment 73 are not performed, and the concentration of the chemical solution is adjusted only by the filling treatment 72A by the continuous dilution method. Also, the chemical liquid is fed to the blood purification device 11 by the liquid feeding process 74A after being adjusted to the target concentration C _t, it is used to disinfect blood purification device 11.

As shown in FIG. 2, in the disinfection step 7 according to the present embodiment, the chemical solution stock solution is pre-filled based on the residual amount of clean water remaining in the pipe, so that the chemical solution is drained (overflowed). The drug solution can be prepared without any need. Therefore, as compared with the comparative example shown in FIG. 3, it is possible to suppress dilution by the clean water remaining in the pipe. Although overflow may occur, it is preferable not to cause overflow because waste of the drug solution stock solution can be suppressed.

Further, by carrying out the pre-filling treatment 71 before the filling treatment 72, it is possible to make the rise of the concentration of the chemical solution agile as compared with the comparative example shown in FIG. Due to the above action, in the disinfection step 7 according to the present embodiment, an increase in the consumption amount of the chemical solution can be suppressed as compared with the comparative example shown in FIG.

(Modification example)
It is not always essential to carry out the prefilling process 71. Dilution by the residual solution may be suppressed. For example, in the filling process 72 by the continuous dilution method, the amount of the drug solution stock solution is larger than the filling amount performed in the filling process 72A of the comparative example, depending on the amount of the residual solution. The undiluted solution may be filled. Here, the timing of filling the filling amount of the chemical solution stock solution may be a fixed time after the filling treatment 72 by the continuous dilution method is started as long as it is before the liquid feeding treatment 74, and before or after the completion of the filling treatment 72. It may be filled for a certain period of time later, for a certain period of time in the middle, or in a plurality of times.

Further, the filling amount is not necessarily limited to a constant value, and the chemical stock solution may be filled while continuously changing (decreasing or increasing) the filling amount, and the filling amount may be gradually changed (decreasing or increasing). However, the chemical solution stock solution may be filled. Further, the rate of change (decrease rate or increase rate) of the filling amount may be constant, may be increased, or may be decreased. In other words, the filling amount may be linearly decreased (or increased) or quadratically decreased (or increased).

(Summary of embodiments)
Next, the technical idea grasped from the above-described embodiment will be described with reference to the reference numerals and the like in the embodiment. However, the respective symbols and the like in the following description are not limited to the members and the like in which the components in the claims are specifically shown in the embodiment.
[1] A drug solution supply device (1) that supplies a drug solution to a blood purification device (11) that performs blood purification treatment, and a preparation unit (2) that mixes a drug solution stock solution and clean water to prepare a drug solution. The chemical solution stock solution is supplied in an amount corresponding to the residual amount of the clean water remaining in the pipe by the distribution process in which the clean water flows through the pipe, the chemical solution is adjusted to a specified concentration, and the blood purification is performed. A chemical solution supply device (1) including a control unit (8) that controls the supply to the device.
[2] The control unit (8) controls so that an amount of the chemical stock solution corresponding to the residual amount is supplied to the pipe before the clean water is supplied, according to the above [1]. Chemical supply device (1).
[3] The control unit (8) controls so that an amount of the chemical stock solution corresponding to the residual amount is supplied to the pipe while the clean water is being supplied, according to the above [1]. Chemical solution supply device (1).
[4] The chemical solution supply device (1) according to the above [2], wherein the control unit controls to supply the chemical solution stock solution to the pipe while changing the filling amount.
[5] A blood purification system (10) comprising the drug solution supply device (1) according to any one of the above [1] to [4] and the blood purification device (11).

Although the embodiments of the present invention have been described above, the embodiments described above do not limit the invention according to the claims. It should also be noted that not all combinations of features described in the embodiments are essential to the means for solving the problems of the invention. In addition, the present invention can be appropriately modified and implemented without departing from the spirit of the present invention. For example, since the clean water used in the post-cleaning process remains in the same manner, when adjusting the chemical solution, the right is to dilute and mix the chemical solution stock solution according to the residual water to adjust the chemical solution to the specified concentration. Included in the range.

1 ... Chemical solution supply device 10 ... Blood purification system 11 ... Blood purification device 12 ... Supply line 13 ... Signal line 2 ... Preparation unit 21 ... Liquid supply line 22 ... Water supply flow meter 23 ... Water supply valve 240 ... A Undiluted solution injection pump 241 ... A Liquid stirring mechanism 250 ... B undiluted solution injection pump 251 ... B liquid agitating mechanism 260 ... Cleaning disinfectant undiluted solution injection pump 261 ... Liquid supply valve 3 ... Liquid feeding unit 31 ... Storage tank 32 ... Liquid feeding pump 33 ... Liquid feeding valve 34 ... First Circulation line 35 ... Second circulation line 4 ... A stock solution tank 5 ... B stock solution tank 6 ... Cleaning disinfectant solution stock solution tank 7 ... Disinfection process 71 ... Pre-filling 72, 72 A ... Filling 73 ... Circulation process 8 ... Control unit

Claims (5)

A drug solution supply device that supplies a drug solution to a blood purification device that performs blood purification treatment.
A preparation department that prepares a chemical solution by mixing the chemical solution stock solution and clean water,
The chemical solution stock solution is supplied in an amount corresponding to the residual amount of the clean water remaining in the pipe by the distribution process in which the clean water flows through the pipe, the chemical solution is adjusted to a specified concentration, and the blood purification is performed. A control unit that controls the supply to the device,
A chemical supply device equipped with. The control unit
Before the clean water is supplied, the amount of the chemical stock solution corresponding to the residual amount is controlled to be supplied to the pipe.
The chemical solution supply device according to claim 1. The control unit
While the clean water is being supplied, the amount of the chemical stock solution corresponding to the residual amount is controlled to be supplied to the pipe.
The chemical solution supply device according to claim 1. The control unit controls to supply the chemical solution stock solution to the pipe while changing the filling amount.
The chemical solution supply device according to claim 2. The chemical solution supply device according to any one of claims 1 to 4.
The blood purification device and
Blood purification system.

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