JP2020176066A - Oral malodor inhibitory composition - Google Patents
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Abstract
Description
本発明は、ケイ素、特に水溶性ケイ素を含む、口臭抑制用組成物、ならびに、口臭の抑制方法に関する。 The present invention relates to a composition for suppressing halitosis containing silicon, particularly water-soluble silicon, and a method for suppressing halitosis.
近年、口腔内環境を清潔に保ち、特に、口臭を除去することについて、多くの人々が関心を持っている。口臭など自己の臭いを気にするあまり、自臭症などを発症することも希ではなく、オーラルケアは社会生活上も重要な関心事の１つとなっている。
さらに、コンパニオンアニマルと共存する現代社会においては、ヒトのみならず、イヌやネコなどの口臭等の対策についても、様々な対策が講じられるようになってきた。特に、イヌやネコなどのペットにおいては、自らの意思によるオーラルケアをすることはなく、また、歯磨きなどを買い主が行うことは、負担が大きい。そのため、ペットのオーラルケアは、よい簡単かつ手軽に使用できる方法が望まれる。
In recent years, many people have been interested in keeping the oral environment clean, especially in removing bad breath. It is not uncommon to develop olfactory reference syndrome because of the concern about one's own odor such as bad breath, and oral care is one of the important concerns in social life.
Furthermore, in the modern society where companion animals coexist, various measures have been taken not only for humans but also for bad breath of dogs and cats. In particular, pets such as dogs and cats do not provide oral care on their own initiative, and it is a heavy burden for the buyer to brush their teeth. Therefore, for oral care of pets, a good, easy and easy method is desired.
このような状況下、これまでに数多くのオーラルケア商品が市場に出回っており、さらに、様々な特徴を持つ製品が今後も開発されることが予想される。例えば、和種ハッカ油とp-メタン-3-カブトキサミド類を含む口腔組成物（特許文献１）、クエン酸などの有機酸を有効成分とする口臭抑制用組成物（特許文献２）、ハイドロキシアパタイトを有効成分とする口腔用組成物（特許文献３）などの報告がある。 Under these circumstances, many oral care products have been on the market so far, and it is expected that products with various characteristics will be developed in the future. For example, an oral composition containing Japanese peppermint oil and p-methane-3-kabutoxamides (Patent Document 1), a composition for suppressing halitosis containing an organic acid such as citric acid as an active ingredient (Patent Document 2), hydroxyapatite. There are reports of oral compositions containing (Patent Document 3) as an active ingredient.
オーラルケア製品は、口腔内を洗浄したのち、洗浄液等を口腔外に捨てるタイプの他、口腔内を洗浄したのち、洗浄液を嚥下することができるタイプなどがあるが、使用場所を選ばないという点では、体内に摂取可能なタイプが好ましく、その有効成分とし、可食しても体に影響を及ぼさないものを使用したタイプが望まれる。さらに、意識的に口腔外に吐き出すことが難しいペットに使用する場合には、可食性である必要がある。可食性の口腔用組成物もいくつか報告されているが（例えば、特許文献３など）、より簡便で安価な製品の開発は現時点においても課題とされている。 Oral care products include a type that cleans the oral cavity and then throws away the cleaning solution, etc., and a type that allows the cleaning solution to be swallowed after cleaning the oral cavity, but it can be used anywhere. Therefore, a type that can be ingested in the body is preferable, and a type that uses an active ingredient that does not affect the body even if edible is desired. Furthermore, it must be edible when used in pets that are difficult to consciously exhale out of the oral cavity. Although some edible oral compositions have been reported (for example, Patent Document 3), the development of simpler and cheaper products is still an issue at present.
上記事情に鑑み、本発明は、生体に悪影響を及ぼさない、可食性の口臭抑制用組成物の提供を目的とする。 In view of the above circumstances, an object of the present invention is to provide an edible halitosis-suppressing composition that does not adversely affect a living body.
本発明者らは、口臭および口腔内細菌に対する水溶性ケイ素の及ぼす影響につき、鋭意検討を行った。ケイ素は生物界に最も多く存在する元素の１つで、ヒトにおいては必須微量元素であると考えられている。ケイ素は、生体内では皮膚や骨などの結合組織に多く分布し、ケイ素摂取量と骨密度には正の相関があることが報告されており（非特許文献１）、また、ラットにおいて、ケイ素の摂取が血管の力学的強度を増加させるとの報告もある（非特許文献２）。従って、ケイ素は生体に対し良好な影響を与える元素の1つであると言うことができる。
発明者らは、水溶性のケイ素を含む水を自由飲水させたイヌの口腔内細菌数と口臭成分である揮発性硫黄化合物（volatile sulfur compounds：VSC）の口腔内濃度を測定したところ、いずれも低下していることを見いだした。
本発明は上記知見に基づいて完成されたものである。
The present inventors have diligently investigated the effects of water-soluble silicon on halitosis and oral bacteria. Silicon is one of the most abundant elements in the living world and is considered to be an essential trace element in humans. It has been reported that silicon is abundantly distributed in connective tissues such as skin and bone in the living body, and that there is a positive correlation between silicon intake and bone density (Non-Patent Document 1), and silicon in rats. There is also a report that ingestion of silicon increases the mechanical strength of blood vessels (Non-Patent Document 2). Therefore, it can be said that silicon is one of the elements that have a good effect on the living body.
The inventors measured the number of bacteria in the oral cavity of dogs that were allowed to drink water containing water-soluble silicon freely and the oral concentration of volatile sulfur compounds (VSC), which is a halitosis component. I found that it was declining.
The present invention has been completed based on the above findings.
すなわち、本発明は以下の（１）〜（５）である。
（１）水溶性ケイ素を含有する口臭抑制組成物。
（２）前記水溶性ケイ素濃度が0.01質量%以上であることを特徴とする上記（１）に記載の口臭抑制組成物。
（３）上記（１）または（２）に記載の口臭抑制組成物を含有する口臭抑制用食品。
（４）上記（１）または（２）に記載の口臭抑制組成物を口腔内部に接触させることを含む、口臭抑制方法。
（５）前記口臭抑制方法の対象がヒト以外のほ乳動物であることを特徴とする（４）に記載の方法。
That is, the present invention is the following (1) to (5).
(1) A halitosis-suppressing composition containing water-soluble silicon.
(2) The halitosis suppressing composition according to (1) above, wherein the water-soluble silicon concentration is 0.01% by mass or more.
(3) A food for halitosis control containing the halitosis control composition according to (1) or (2) above.
(4) A method for suppressing halitosis, which comprises bringing the halitosis suppressing composition according to (1) or (2) above into contact with the inside of the oral cavity.
(5) The method according to (4), wherein the target of the method for suppressing halitosis is a mammal other than human.
本発明によれば、簡便な方法により口臭を抑えることができる。 According to the present invention, bad breath can be suppressed by a simple method.
本発明にかかる口臭抑制組成物は、生体に悪影響を及ぼさない可食性の組成物であるため、吐き出しの困難なヒト以外の動物の口臭抑制を目的としても使用可能である。 Since the halitosis-suppressing composition according to the present invention is an edible composition that does not adversely affect the living body, it can also be used for the purpose of suppressing halitosis in animals other than humans who have difficulty in exhaling.
本発明の第１の実施形態は、水溶性ケイ素を含有する口臭抑制用組成物（以下「本発明の口臭抑制用組成物」とも記載する）である。
「口臭抑制用組成物」とは、口腔内の細菌の除去もしくは増殖抑制および口臭の除去もしくは抑制の目的で使用される組成物である。ここで、「口臭」とは、ヒトを含む動物の呼気の臭いのことで、具体的にはヒトが不快に感じる臭いのことである。ヒトが不快に感じる臭いの原因物質は様々なものが存在するが、例えば、揮発性硫黄化合物（VSC：volatile sulfur compound）などを挙げることができる。
本発明の口臭抑制用組成物は、水溶性ケイ素を含んでなるものである。本発明において、水溶性ケイ素とは、水に溶解可能で、生体内に摂取されやすい特徴を有するケイ素のことで、例えば、「umo（登録商標）」（株式会社APAコーポレーション）などを挙げることができる。水溶性ケイ素（例えば、umo）は、水晶石や植物系ケイ素などから、特殊な抽出法によって抽出したものである。例えば、水溶性ケイ素は、二酸化ケイ素（SiO2）を多く含む水晶石を高温（2,000℃以上）の溶解釜で燃焼して、ガス化したケイ素成分を特殊な方法で回収し、不要な物質を燃焼処理した後、水溶性の結晶として抽出される。
本発明の全ての実施形態において使用する「水溶性ケイ素」は、液体または固体（粉体を含む）のいずれであっても良い。水溶性ケイ素の製造方法については、例えば、特開2017-57156などに開示されている。水溶性ケイ素の使用にあたっては、umoマークや日本珪素医科学学会の名前が入っている市販品を購入して用いてもよい。
The first embodiment of the present invention is a halitosis-suppressing composition containing water-soluble silicon (hereinafter, also referred to as "the halitosis-suppressing composition of the present invention").
The "composition for suppressing halitosis" is a composition used for the purpose of removing or suppressing the growth of bacteria in the oral cavity and removing or suppressing halitosis. Here, the "halitosis" is the odor of the exhaled breath of animals including humans, and specifically, the odor that humans feel unpleasant. There are various substances that cause odors that humans feel unpleasant, and examples thereof include volatile sulfur compounds (VSCs).
The composition for suppressing mouth odor of the present invention comprises water-soluble silicon. In the present invention, the water-soluble silicon is silicon having a characteristic of being soluble in water and easily ingested in a living body, and examples thereof include "umo (registered trademark)" (APA Corporation). it can. Water-soluble silicon (for example, umo) is extracted from quartz stone, plant-based silicon, etc. by a special extraction method. For example, in water-soluble silicon, quartz stone containing a large amount of silicon dioxide (SiO 2 ) is burned in a melting pot at a high temperature (2,000 ° C or higher), and the gasified silicon component is recovered by a special method to remove unnecessary substances. After combustion treatment, it is extracted as water-soluble crystals.
The "water-soluble silicon" used in all embodiments of the present invention may be either liquid or solid (including powder). A method for producing water-soluble silicon is disclosed in, for example, Japanese Patent Application Laid-Open No. 2017-57156. When using water-soluble silicon, a commercially available product bearing the umo mark or the name of the Japan Silicon Medical Science Society may be purchased and used.
本発明の口臭抑制用組成物は、その使用方法、例えば、口腔内に含んだ後飲み込む方法、口腔内に含んで口腔内を洗浄する方法、口腔内において滞留させる方法、口腔内で有効成分を徐々に放出させる方法などの使用態様に適した形態や形状で提供することができる。従って、本発明の口臭抑制用組成物の形態として、特に限定しないが、液体（泡状、霧状を含む）、固体、ゲル状、ペースト状などであってもよい。より具体的には、例えば、タブレット、ガム、グミ、キャンディー、飴および飲料などの食品組成物の形態、可食フィルム、歯磨剤、洗口剤、義歯洗浄剤、スプレー剤など口腔ケア組成物の形態などが挙げられる。 The halitosis-suppressing composition of the present invention is used, for example, a method of swallowing after containing it in the oral cavity, a method of cleaning the oral cavity by containing it in the oral cavity, a method of retaining it in the oral cavity, and an active ingredient in the oral cavity. It can be provided in a form or shape suitable for a usage mode such as a method of gradually releasing the substance. Therefore, the form of the composition for suppressing halitosis of the present invention is not particularly limited, but may be liquid (including foamy and mist-like), solid, gel-like, and paste-like. More specifically, for example, forms of food compositions such as tablets, gums, gummies, candies, candies and beverages, oral care compositions such as edible films, dentifrices, mouthwashes, denture cleaners and sprays. The form and the like can be mentioned.
本発明の口臭抑制用組成物は、有効成分である水溶性ケイ素以外に、組成物の形態を維持または安定化するための物質を含んでもよく、限定はしないが、例えば、基剤、添加剤（賦形剤、滑沢剤、酸味料、甘味料、乳化剤、酸化防止剤、結合材、保存剤、防腐剤、pH調整剤、増粘剤、粘着剤、発泡剤、安定剤、軟化剤、着色料、香料および調味料など）および栄養成分（例えば、タンパク質、脂質、炭水化物およびビタミンなど）を含んでいてもよく、さらに、他の口臭抑制成分や口腔衛生用成分などを含んでいてもよい。 The composition for suppressing halitosis of the present invention may contain, in addition to the active ingredient, water-soluble silicon, a substance for maintaining or stabilizing the form of the composition, and is not limited, for example, a base or an additive. (Excipients, lubricants, acidulants, sweeteners, emulsifiers, antioxidants, binders, preservatives, preservatives, pH regulators, thickeners, adhesives, foaming agents, stabilizers, softeners, It may contain colorants, flavors and seasonings, etc.) and nutritional components (eg, proteins, lipids, carbohydrates, vitamins, etc.), and may also contain other halitosis-suppressing components, oral hygiene components, and the like. ..
本発明の口臭抑制用組成物に含まれるケイ素の含有量は、口臭を抑制する効果を発揮し、口に含んだときに苦みなどの不快感がない量であれば、特に限定はされず、例えば、0.008質量%〜0.8質量%、好ましくは、0.01質量%〜0.6質量%、より好ましくは、0.02質量%〜0.4質量%である。
また、本発明の口臭抑制用組成物の一日の使用回数は、使用対象、口臭の度合いなどに応じて、適宜選択することが可能で、数回〜数十回程度使用することができる。また、本発明の口臭抑制用組成物は可食性であるが、好ましくは、口腔内で数分程度滞留させた後、飲み込むことが好ましい。
The content of silicon contained in the composition for suppressing halitosis of the present invention is not particularly limited as long as it exerts an effect of suppressing halitosis and does not cause discomfort such as bitterness when it is contained in the mouth. For example, it is 0.008% by mass to 0.8% by mass, preferably 0.01% by mass to 0.6% by mass, and more preferably 0.02% by mass to 0.4% by mass.
Further, the number of times of use of the halitosis suppressing composition of the present invention per day can be appropriately selected according to the object of use, the degree of halitosis, etc., and can be used several times to several tens of times. The halitosis-suppressing composition of the present invention is edible, but it is preferably allowed to stay in the oral cavity for about several minutes and then swallowed.
本発明の口臭抑制用組成物の使用対象は、口臭のある動物であれば特に限定されず、例えば、鳥類、哺乳類、特に、ヒトおよびヒト以外のほ乳動物で、例えば、イヌ、ネコ、ウサギ、フェレットなどのペットとして飼育される動物、ウシ、ブタ、ウマ、ヤギ、ヒツジなど家畜として飼育される動物などを挙げることができる。 The object of use of the composition for suppressing bad odor of the present invention is not particularly limited as long as it is an animal having bad odor, for example, birds, mammals, particularly humans and non-human mammals, for example, dogs, cats, rabbits, etc. Examples include animals bred as pets such as ferrets, and animals bred as domestic animals such as cows, pigs, horses, goats, and sheep.
本発明の第２の実施形態は、本発明の口臭抑制用組成物を口腔内部に接触させることを含む、口臭抑制方法（以下「本発明の口臭抑制方法」とも記載する）である。
本発明の口臭抑制用組成物を「口腔内部に接触させる」とは、本発明の口臭抑制用組成物を口腔に含み、可能であれば口腔内に滞留させ、口腔内部に本発明の口腔用組成物を行き渡らせ、有効成分である水溶性ケイ素が口腔内の粘膜組織等に接触可能にすることである。特に限定はしないが、例えば、本発明の口臭抑制用組成物を口腔内に含んで滞留させ、濯ぐ（当該口臭抑制用組成物が液体の場合）、溶解させる（当該口臭抑制用組成物が固体の場合）などすることで、当該口臭抑制用組成物を口腔内部に行き渡らせることが可能である。または、液体状の本発明の口臭抑制用組成物を霧状または泡状にして口腔内にスプレーする方法で、当該口臭抑制用組成物を口腔内部に接触させてもよい。
本発明の口臭抑制用組成物は、飲料または食物に混合し、これらを飲食することでも口臭抑制効果が発揮される。
A second embodiment of the present invention is a halitosis suppressing method (hereinafter, also referred to as "the halitosis suppressing method of the present invention"), which comprises contacting the halitosis suppressing composition of the present invention with the inside of the oral cavity.
"The composition for suppressing halitosis of the present invention is brought into contact with the inside of the oral cavity" means that the composition for suppressing halitosis of the present invention is contained in the oral cavity, and if possible, is retained in the oral cavity, and the composition for suppressing halitosis of the present invention is kept inside the oral cavity. The composition is spread so that the active ingredient, water-soluble silicon, can come into contact with the mucosal tissue in the oral cavity. Although not particularly limited, for example, the halitosis-suppressing composition of the present invention is contained in the oral cavity, retained, rinsed (when the halitosis-suppressing composition is a liquid), and dissolved (the halitosis-suppressing composition is: By (in the case of a solid) or the like, it is possible to spread the halitosis-suppressing composition inside the oral cavity. Alternatively, the halitosis-suppressing composition of the present invention in liquid form may be brought into contact with the inside of the oral cavity by a method of atomizing or foaming and spraying into the oral cavity.
The halitosis-suppressing composition of the present invention can also exert a halitosis-suppressing effect by mixing it with a beverage or food and eating or drinking these.
本明細書において引用されたすべての文献の開示内容は、全体として明細書に参照により組み込まれる。また、本明細書全体において、単数形の「a」、「an」、および「the」の単語が含まれる場合、文脈から明らかにそうでないことが示されていない限り、単数のみならず複数のものを含むものとする。
以下に実施例を示してさらに本発明の説明を行うが、実施例は、あくまでも本発明の実施形態の例示にすぎず、本発明の範囲を限定するものではない。
The disclosures of all references cited herein are incorporated herein by reference in their entirety. Also, throughout the specification, when the singular words "a", "an", and "the" are included, not only the singular but also multiple, unless the context clearly indicates otherwise. It shall include things.
Hereinafter, the present invention will be described with reference to examples, but the examples are merely examples of embodiments of the present invention and do not limit the scope of the present invention.
１．材料および実験方法
１−１．動物
実験には、麻布大学生物科学総合研究所で飼育している雄性ビーグル犬4匹、雌性ビーグル犬1匹の計5匹を使用した。動物は、動物飼育室（室温21±2℃、湿度55±5%、12時間明暗期）で飼育し、食餌（CD-5M、日本配合飼料株式会社）は、1日2回（6時〜10時と16時〜20時の間に、10 g/kg／回を給餌）とし、新鮮な水道水を自由摂取とした。
1. 1. Materials and experimental methods 1-1. For the animal experiments, four male beagle dogs and one female beagle dog kept at the Institute of Biological Sciences, Azabu University were used, for a total of five animals. Animals are bred in an animal breeding room (room temperature 21 ± 2 ° C, humidity 55 ± 5%, 12 hours light and dark period), and the diet (CD-5M, Nippon Formula Feed Co., Ltd.) is twice a day (from 6:00). Between 10:00 and 16:00 to 20:00, 10 g / kg / dose was fed), and fresh tap water was freely ingested.
１−２．実験プロトコル
濃縮水溶性ケイ素溶液（水溶性ケイ素濃度；8370 ppm=0.873質量%）（umo（登録商標）、株式会社APA コーポレーション）を1%（水溶性ケイ素濃度；0.00837質量％）および5%（水溶性ケイ素濃度；0.04185質量％）混合した水を、実験動物であるイヌに4週間、飲水させた。飲水前、飲水開始2週間後および4週間後の口内空気中の揮発性硫黄化合物（VSC：volatile sulfur compound）を測定した。VSC測定時に、口内細菌数の測定と簡易キット（オーラストリップ）による口臭評価を行った。また、試験期間中、毎日飲水量を計測した。
1-2. Experimental Protocol Concentrated water-soluble silicon solution (water-soluble silicon concentration; 8370 ppm = 0.873% by mass) (umo (registered trademark), APA Corporation) 1% (water-soluble silicon concentration; 0.00837% by mass) and 5% (water-soluble) (Silicon concentration; 0.04185% by mass) The mixed water was allowed to drink in dogs, which are experimental animals, for 4 weeks. Volatile sulfur compounds (VSCs) in the oral air were measured before drinking, 2 weeks after the start of drinking, and 4 weeks after the start of drinking. At the time of VSC measurement, the number of bacteria in the mouth was measured and halitosis was evaluated using a simple kit (aura strip). In addition, the amount of drinking water was measured every day during the test period.
１−３．口腔内細菌数の測定
Takahashi らの方法（Takahashiら, Fundam. Toxicol. Sci., 2:83-87 2015）に従って、白色滅菌綿棒で左上4顎臼第歯頬側を3回擦り、それを自動細菌数計算装置（DU-AAOl NP-H、パナソニックヘルスケア株式会社）を用いて測定した。1匹につき2回測定し、平均値を求めた。
1-3. Measurement of the number of bacteria in the oral cavity
According to the method of Takahashi et al. (Takahashi et al., Fundam. Toxicol. Sci., 2: 83-87 2015), rub the buccal side of the upper left 4 jaws with a white sterile cotton swab three times, and use it as an automatic bacterial count calculator (DU). -Measured using AAOl NP-H (Panasonic Healthcare Co., Ltd.). Each animal was measured twice and the average value was calculated.
１−４．口腔内揮発性硫黄化合物濃度の測定（オーラルクロマ）
本実施例において、オーラルクロマ（CHM-2、FIS Inc., Hyogo, Japan）を用いてヒトの口臭原因物質として報告されているVSCである硫化ジメチル（(CH3)2S）を測定対象とした。Iwashitaらの方法（Iwashitaら, Fundam. Toxicol. Sci., 4:23-29 2017）に従って、犬歯と臼歯との間隙に1 mL シリンジに装着したチューブを挿入し、イヌの呼気サンプルを採取した。
1-4. Measurement of Oral Volatile Sulfur Compound Concentration (Oral Chroma)
In this example, dimethyl sulfide ((CH 3 ) 2 S), which is a VSC reported as a substance causing halitosis in humans, was measured using oral chroma (CHM-2, FIS Inc., Hyogo, Japan). did. According to the method of Iwashita et al. (Iwashita et al., Fundam. Toxicol. Sci., 4: 23-29 2017), a tube attached to a 1 mL syringe was inserted into the gap between the canine and the molar, and a dog breath sample was taken.
１−５．簡易口臭測定（オーラストリップ）
オーラストリップ（DS Pharma Animal Health Co. Ltd, Osaka, Japan）を用いてイヌの口臭を測定した。オーラストリップは歯周病原菌によって産生されるチオールレベルを検出することで、獣医師が歯周感染を確認するために開発された（Manfra Marrettaら, Can. Vet. J., 53:1260-1265 2012）。この試験紙で歯肉を拭うと、イヌの口腔内にあるチオール化合物と試験紙が反応し、チオールレベルが色の違いによって5段階で評価され、歯周病の活性を確認することができる。
1-5. Simple halitosis measurement (aura strip)
Halitosis in dogs was measured using an aura strip (DS Pharma Animal Health Co. Ltd, Osaka, Japan). Aura strips were developed by veterinarians to identify periodontal infections by detecting thiol levels produced by periodontal pathogens (Manfra Marretta et al., Can. Vet. J., 53: 1260-1265 2012). ). When the gingiva is wiped with this test paper, the thiol compound in the oral cavity of the dog reacts with the test paper, and the thiol level is evaluated on a 5-point scale according to the difference in color, and the activity of periodontal disease can be confirmed.
２．結果
２−１．水溶性ケイ素の口腔内細菌数に及ぼす影響
口臭の変化は口腔内細菌叢の変化を伴うことが考えられる。そこで、細菌叢の変化の１つの指標として、口腔内細菌数を測定した。その結果を図１に示す。水溶性ケイ素投与前（Pre）と比較すると、投与後の細菌数（2wおよび4w）は、減少傾向にあった。5%投与群では、2週間後に比べ4週間後で有意な差が認められた。この結果から、水溶性ケイ素の摂取により口腔内細菌の全体数が減少し、細菌の種類や割合、すなわち、細菌叢が変化することが示唆された。
2. Result 2-1. Effect of water-soluble silicon on the number of bacteria in the oral cavity Changes in halitosis may be accompanied by changes in the oral bacterial flora. Therefore, the number of bacteria in the oral cavity was measured as one index of the change in the bacterial flora. The result is shown in FIG. Compared with before administration of water-soluble silicon (Pre), the number of bacteria (2w and 4w) after administration tended to decrease. In the 5% administration group, a significant difference was observed after 4 weeks compared with 2 weeks. This result suggests that ingestion of water-soluble silicon reduces the total number of oral bacteria and changes the type and proportion of bacteria, that is, the bacterial flora.
２−２．水溶性ケイ素の口腔内VSC濃度に対する影響
口腔内ガス中に存在するVSCのうち、ヒトの口臭の主な原因物質と知られている硫化ジメチル（(CH3)2S）を測定した。その結果を図２に示す。
1%投与群では4週間後に、5%投与群では2週間後に(CH3)2S濃度の減少が認められ、5%投与群では投与前と4週間後で(CH3)2S濃度に有意差が認められた。また、5%投与群では、2週間後には(CH3)2S濃度の減少が見られ、1%投与群との(CH3)2S濃度差が認められた（図２）。
2-2. Effect of water-soluble silicon on oral VSC concentration Among the VSCs present in the oral gas, dimethyl sulfide ((CH 3 ) 2 S), which is known to be the main causative agent of human halitosis, was measured. The result is shown in FIG.
A decrease in (CH 3 ) 2 S concentration was observed in the 1% group after 4 weeks, in the 5% group after 2 weeks, and in the 5% group before and after 4 weeks (CH 3 ) 2 S concentration. A significant difference was observed. Also, the 5% administration group, after 2 weeks (CH 3) 2 decreased S concentration was observed, and 1% administration group (CH 3) 2 S concentration difference was observed (Figure 2).
２−３．水溶性ケイ素の口臭に対する影響
オーラストリップを用いた簡易口臭測定の結果を図３に示す。1%の飲水ではわずかな効果が確認された。一方、5%の水の飲水では、強い口臭であるスコア5を示した被験犬のスコアが、2週間で大きく減少し平均でスコア3まで改善し、4週間後でも平均スコア3.2と改善された。
図１から図３の結果から、umo（登録商標）を約1%〜3%以上含む水、すなわち、水溶性ケイ素濃度が約0.01質量％〜0.03質量%以上を含む水を飲水することで、イヌの口臭が軽減されることが示された。
2-3. Effect of water-soluble silicon on halitosis Figure 3 shows the results of simple halitosis measurement using an aura strip. A slight effect was confirmed with 1% drinking water. On the other hand, with 5% water drinking, the score of the test dog showing a strong bad breath score of 5 decreased significantly in 2 weeks and improved to an average score of 3, and improved to an average score of 3.2 even after 4 weeks. ..
From the results of FIGS. 1 to 3, by drinking water containing about 1% to 3% or more of umo (registered trademark), that is, water containing about 0.01% by mass to 0.03% by mass or more of water-soluble silicon, It has been shown that halitosis in dogs is reduced.
本発明は、口臭を抑制する組成物を提供するもので、オーラルケア関連製品の開発分野においての利用が期待される。 The present invention provides a composition that suppresses halitosis, and is expected to be used in the development field of oral care-related products.
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