JP2020167958A - Edible fat for promoting sodium excretion - Google Patents

Abstract

To provide edible fat for promoting sodium excretion having a function of sodium excretion promotion and a method of producing the edible fat for promoting sodium excretion.SOLUTION: Edible fat of this invention promotes sodium excretion, in which the total content of tocopherol including its plural homologs is 1,000 ppm or more; in the total content of tocopherol, an α-tocopherol content is 10-40 mass% and a γ-tocopherol content is 60-90 mass%; and the total content of tocopherol is 6,000 ppm or less.SELECTED DRAWING: Figure 5

Description

The present invention relates to edible oils and fats having an excellent action of promoting excretion of sodium from the body.

Japanese foods that we are familiar with often contain a lot of salt, and Japanese people tend to consume excessive amounts of salt on a daily basis. It has been pointed out that excessive intake of salt is associated with swelling of the body, stiff shoulders, hypertension, circulatory system diseases, etc., and causes various adverse effects on the body. Therefore, it can be said that the action of promoting sodium excretion in foods has a strong appeal to Japanese people who are concerned about excessive intake of salt.

In recent years, with the growing health consciousness of consumers, various foods with functional health such as foods for specified health use (Tokuho) and foods with nutritional function have been put on the market. In the field of edible oils and fats, products that claim to be oils that do not easily get fat or oils that lower cholesterol are commercially available. In general, food additives are often added in order to impart functionality to edible fats and oils.

As a food additive added to edible fats and oils, for example, tocopherol (hereinafter, also referred to as Toc), which is a natural antioxidant component, is known. Tocopherols include α-tocopherol (hereinafter, also referred to as α-Toc), β-tocopherol (hereinafter, also referred to as β-Toc), γ-tocopherol (hereinafter, also referred to as γ-Toc), and δ-tocopherol (hereinafter, also referred to as γ-Toc). , Δ-Toc), there are four types of relatives. Of these, α-Toc mainly exerts the biological activity of vitamin E, and only α-Toc is counted as vitamin E in food labeling. On the other hand, it is known that δ-Toc exerts the highest effect as an antioxidant for foods and the like. Therefore, in general, when increasing the tocopherol content of edible fats and oils, a Toc preparation containing a large amount of α-Toc or δ-Toc is often added as a strengthening agent or an antioxidant.

Further, in recent years, it has been found that γ-Toc also exerts an important physiological action in the living body. For example, Non-Patent Document 1 reveals that γ-carboxyethyl hydroxychroman (γ-CEHC), which is a metabolite of γ-Toc, is a sodium excretion-promoting hormone. In this document, it is reported that a single administration of γ-Toc to rats overdose of sodium chloride increases sodium excretion. However, no example of evaluation using edible fats and oils containing γ-Toc has been reported, and edible fats and oils claiming to promote sodium excretion have not been known so far.

The applicant can suppress an increase in acid value over time by returning the deodorized distillate (deodorized scum) generated in the deodorizing step to the initial stage of refining the raw material crude oil without refining. It has been reported that edible oils and fats can be obtained (see Patent Document 1). In this patent document, it is described that a large amount of tocopherol is contained. However, the relationship between the edible oil and fat and the excretion promoting action of sodium has not been investigated at all.

JP-A-2015-73453

S. Yoshikawa et al, "European Journal of Clinical Nutrition", 2005, 59, p. 900-905

An object of the present invention is to provide an edible oil / fat for promoting sodium excretion having a function of promoting sodium excretion, and a method for producing the edible oil / fat for promoting sodium excretion.

The edible oil / fat for promoting sodium excretion of the present invention (hereinafter, also simply referred to as edible oil / fat) promotes the excretion of sodium, and the total content of tocopherol containing a plurality of homologues is 1,000 ppm or more. It is characterized in that the content of α-tocopherol is 10 to 40% by mass and the content of γ-tocopherol is 60 to 90% by mass in the total content of tocopherol.

Homologues of α-, β-, γ-, and δ- are known for tocopherols. In the present invention, the "total content of tocopherol" means the total amount of all homologues contained in tocopherol in the edible oil and fat of the present invention. For example, when tocopherol in edible fats and oils is composed of α-, γ-, and δ- homologues, it means the total amount of α-tocopherol, γ-tocopherol, and δ-tocopherol. The tocopherol in the present invention does not contain tocotrienols having a structure similar to that of tocopherol.

The total content of the tocopherol is 6,000 ppm or less. Further, the edible oil and fat and the tocopherol are characterized by being derived from rapeseed or corn.

In the method for producing an edible oil / fat for promoting sodium excretion of the present invention, a raw material crude oil produced through at least one step of a pressing step and an extraction step is subjected to a degumming step, a deoxidizing step, a decoloring step, and a deodorizing step in order. It is a method of producing through the process, and is characterized in that the deodorized distillate distilled in the deodorizing step is returned to crude oil after the degumming step and before the deoxidizing step.

The above-mentioned production method is characterized by not including a step of adding a tocopherol preparation.

The edible oil and fat for promoting sodium excretion of the present invention has a total content of tocopherol containing a plurality of homologues of 1,000 ppm or more, and the content of α-tocopherol is 10 to 40% by mass of the total content of tocopherol. Since the content of γ-tocopherol is 60 to 90% by mass, it can be expected that γ-CEHC, which is a sodium excretion promoting hormone, is efficiently produced from γ-tocopherol when the edible oil and fat is ingested. .. In addition, this can be expected to promote the excretion of sodium.

In the production method of the present invention, the deodorized distillate containing a large amount of tocopherol is returned to crude oil after the degumming step and before the deoxidizing step, so that the natural Toc originally possessed by the plant can be extracted. , Tocopherol is contained in a high concentration, and the content of α-tocopherol and γ-tocopherol is within a predetermined range, and an edible fat or oil for promoting sodium excretion can be obtained. In addition, edible fats and oils for promoting sodium excretion can be produced without separately adding a tocopherol preparation, which is a food additive, to fats and oils or products in the manufacturing process.

It is a manufacturing process diagram of the edible oil and fat of this invention. It is a figure which shows the tocopherol content of each test fat and oil. It is a manufacturing process diagram of the test fat and oil of Comparative Example 1. It is a figure which shows the urine volume of each test example in a continuous administration test. It is a figure which shows the total sodium excretion amount of each test example in a continuous administration test. It is a figure which shows each tocopherol content in a rat liver. It is a figure which shows the pharmacokinetics of the tocopherol homologue contained in the test fat and oil.

As a result of diligent studies to obtain edible fats and oils for promoting sodium excretion, the present inventors continuously administer edible fats and oils containing a relatively large amount of tocopherol and a predetermined amount of α-tocopherol and γ-tocopherol to rats. We found that it promotes the excretion of sodium. The present invention is based on such findings.

The edible oil and fat of the present invention has a total content of tocopherol containing a plurality of homologues of 1,000 ppm or more, and the content of α-tocopherol is 10 to 40% by mass among the total content of tocopherol, which is that of γ-tocopherol. The content is 60 to 90% by mass. The total content of tocopherol in the edible fat is preferably 1,200 ppm or more, more preferably 1,500 ppm or more. The upper limit of the total content is not particularly limited, but is preferably 6,000 ppm or less, more preferably 4,000 ppm or less, and further preferably 2,000 ppm or less from the viewpoint of coloring.

In the present invention, it is important not only that a large amount of γ-Toc is contained as tocopherol, but also that α-Toc is contained in a predetermined amount or more (10% by mass or more) while having a high content of γ-Toc. For each content, the α-Toc content is preferably 20 to 40% by mass, the γ-Toc content is 60 to 80% by mass, and more preferably the α-Toc content is 25 to 50% by mass. It is 35% by mass and the content of γ-Toc is 65 to 75% by mass.

The tocopherol contained in the edible oil and fat of the present invention is derived from a natural component, not from a tocopherol preparation. Further, the edible oil and fat used in the present invention may contain tocopherol homologues other than α- and γ-, that is, β-tocopherol and δ-tocopherol. The content of these is not particularly limited, but is preferably smaller than that of α-tocopherol. As the tocopherol contained in the edible oil and fat of the present invention, δ-tocopherol is preferably contained in an amount of 1 to 10% by mass, more preferably 1 to 5% by mass, based on the total content of tocopherol.

FIG. 1 shows a production process diagram of an edible oil / fat for promoting sodium excretion of the present invention. Raw materials A before crude oil B is extracted include, for example, amani, perilla, perilla, capoc, copra, sesame, rice bran, safflower, shea nut, soybean, tea, corn, rapeseed, niger, babas, palm, etc. Examples include palm kernels, palms, sunflowers, cotton seeds, peanuts, grapes, wheat, olives and avocado. Among these, it is preferable to use rapeseed or corn from the viewpoint of Toc composition. Here, Table 1 shows the results of analyzing the Toc composition of commercially available canola oil (manufactured by Tsuji Oil Co., Ltd.) and commercially available corn oil (manufactured by Tsuji Oil Co., Ltd.). As shown in Table 1, it can be seen that rapeseed and corn have similar Toc compositions.

Crude oil B can be produced by using the raw material A in combination with the pressing step 1, the extraction step 2, or the pressing step 1 and the extraction step 2. The conditions of the pressing step 1 or the extraction step 2 can be appropriately changed depending on the type and state of the raw material A. For example, when the raw material A is rapeseed, the pressing step 1 and the extraction step 2 are used in combination, and when the raw material A is soybean, the extraction step 2 is the main step. Crude oil B contains lecithin, pigments, wax components, odorous components and the like.

The crude oil B obtained from the raw material A includes, for example, saflower oil, grape oil, soybean oil, sunflower oil, wheat germ oil, corn oil, cottonseed oil, sesame oil, rapeseed oil, rice oil, peanut oil, flax oil, and the like. Egoma oil, olive oil, palm oil, palm oil (including edible fractionated oils such as palm olein, palm stea, palm super olein, palm mid fraction, etc.), these hydrogenated oils, ester exchange oils, etc., as well as medium chain fatty acid triglycerides. Examples thereof include edible oils produced by a direct esterification reaction such as.

The degumming step 3 is a step of adding water, steam, acid, or the like to hydrate and separate the gum containing lecithin in the crude oil B, and is generally treated at a high temperature of 70 to 80 ° C.
The deoxidizing step 4 is a step of neutralizing the free fatty acids in the crude oil after degumming by adding an alkaline aqueous solution to remove the generated deoxidized oil pits (alkaline foots).
The decolorizing step 5 is a step of adding activated clay to adsorb pigment components and other trace amounts of impurities in the deoxidized crude oil and remove them as decolorized oil pits (waste clay). Depending on the type of crude oil, a dewaxing step may be provided after the decolorization step 5 in which the crude oil is gently cooled and stirred to filter and separate the wax content and the refractory oil in the crude oil.
The deodorizing step 6 is a step of removing the deodorized distillate D (deodorizing scum) in the decolorized crude oil by steam distillation under high temperature (200 ° C. or higher) and high vacuum.

The deodorized distillate D contains hydrocarbons such as tocopherol, plant sterol, and squalene in addition to free fatty acids, and its composition (including Toc composition) differs depending on the type of crude oil B. In the present invention, the deodorized distillate D is returned to the crude oil before the deodorizing step 6 without being discarded or refined. The deodorized distillate D is preferably returned to crude oil derived from the same kind of raw material. More preferably, it is returned to the crude oil of the same production lot. By returning to the crude oil of the same production lot, the crude oil B itself becomes an edible oil and fat having an increased tocopherol content without adding food additives.

As a method of returning the deodorized distillate D to crude oil, (1) the deodorized distillate D is collected in advance by the step shown in FIG. 1, and the deodorized distillate D is used as a crude oil derived from the same kind of raw material. Examples thereof include a method of returning, and (2) a recycling method of repeating returning the deodorized distillate D collected by the step shown in FIG. 1 to crude oil derived from the same kind of raw material. In the method (1) above, the concentration of tocopherol contained in the product C can be increased. Further, in the method (2) above, the concentration of tocopherol contained in the product C is substantially the same as the amount contained in the crude oil B, but compared with the production method in which the deodorized distillate was removed (see FIG. 3). Therefore, the tocopherol concentration can be increased.

Regarding the ratio of returning the deodorized distillate D to crude oil, the tocopherol content contained in the final product C is preferably 1,000 to 6,000 ppm, more preferably 1,200 to 4,000 ppm, still more preferably 1, It is to return to 500 to 2,000 ppm.

The deodorized distillate D may be returned to the crude oil in the crude oil before the deodorizing step 6 as shown by the solid line arrow or the broken line arrow from the deodorized distillate D in FIG. As shown by the solid arrow, the deodorized distillate D is preferably returned before the deoxidizing step 4. By returning to the pre-deoxidation step 4, the final product C having an excellent flavor and a light hue can be produced without leaving the odor peculiar to the deodorized distillate D.

When the deodorized distillate D is collected in advance, the first deodorized distillate D obtained from the crude oil B shall be deodorized at a relatively high temperature, preferably 220 ° C. or higher and lower than 250 ° C. in the deodorizing step 6. Therefore, a large amount of deodorized distillate can be obtained. At 250 ° C. or higher, the trans fatty acid content in the final product increases, and below 220 ° C., the amount of deodorized distillate D produced decreases, and the transfer of tocopherol to deodorized distillate D tends to decrease. The deodorized final product at this time can be used as a highly refined edible oil / fat that does not contain the deodorized distillate D, unlike the edible oil / fat of the present invention.
The crude oil deodorizing step 6 in which the obtained deodorized distillate D is returned is deodorized at a temperature lower than the temperature at which the first deodorized distillate D is obtained, preferably at a temperature of 200 ° C. or higher and 230 ° C. or lower. By deodorizing at a low temperature, product C having an increased content of tocopherol, plant sterol, etc. can be obtained. It can also suppress the production of trans fatty acids, which increases the risk of cardiovascular disease.

Since the edible oil / fat for promoting sodium excretion of the present invention has a sodium diuretic effect, it is suitable as, for example, an edible oil / fat for consumers who continue to eat a salty meal or who are concerned about swelling. Further, the edible oil and fat of the present invention is preferably used as a base oil for seasoning oils and flavor oils, which are frequently used in daily eating habits, and as a base oil for supplements such as capsules.

Production of edible oils and fats for promoting sodium excretion The crude oil obtained by pressing and extracting rapeseed was degummed according to a conventional method. To this rapeseed crude oil after degumming, an aqueous solution of caustic soda having an alkali concentration of 16.6% was added according to the amount of free fatty acids obtained from the measured acid value, and reacted at 60 ° C. for 30 minutes to produce the crude oil. The free fatty acids in the oil were removed as deoxidized oil pans (alkaline foots). Activated clay was added at a ratio of 1.2 parts by weight to 100 parts by weight of crude oil after the deoxidizing step, and reacted at 103 ° C. for 60 minutes at a vacuum degree of 40 Torr to decolorize, and then at a temperature of 240 ° C., 69. A deodorized distillate was obtained by deodorizing with a high vacuum (5 torr or less) and a blown steam amount of 1.67% for 1 minute. The deodorized distillate contained 5.762% by weight of tocopherol and 19.25% by weight of plant sterols.

The crude oil obtained by pressing and extracting the rapeseed was degummed according to a conventional method in the same manner as in the distribution of the deodorized distillate. To the rapeseed crude oil after degumming, the unrefined rapeseed oil deodorized distillate previously separated from the rapeseed crude oil was added to the mixture as a whole so as to be 2.2% by weight. Subsequently, edible oils and fats were produced through a deoxidizing step, a decoloring step, and a deodorizing step in the same manner as in the above-mentioned sorting of the deodorized distillate. The deodorizing step was carried out at a temperature of 225 ° C. for 78 minutes at a high vacuum (5 torr or less) and a steam blown amount of 2.07%. The obtained rapeseed oil was used as an edible oil / fat for promoting sodium excretion. This edible oil and fat contained 1,664 ppm of tocopherol in total. The Toc composition contained 26.2% by mass of α-Toc, 71.7% by mass of γ-Toc, and 2.1% by mass of δ-Toc.

In the following, a verification test of physiological functionality was conducted by an animal test. Regarding this test, in order to adjust the amount of fats and oils to be ingested by rats from the balance between the average rat body weight and the average human body weight, a fats and oils for administration test in which the Toc content was intentionally contained at a higher concentration than usual were prepared and tested. went. Finally, in consideration of comparative conversion, it was determined that the amount was sufficiently ingested by humans per day.

Example 1
The edible oil and fat of Example 1 was produced in the same manner as the above-mentioned production of the edible oil and fat for promoting sodium excretion. The amount of the deodorized distillate added was 8.0% by weight, and the amount of steam blown was 33%. The obtained fats and oils for administration test contained about 3 times more tocopherol than the above-mentioned fats and oils for promoting sodium excretion, and contained 5,014 ppm in total.

Table 2 shows the characteristics of the obtained test fats and oils. Each characteristic value was measured by the following method.
[moisture]
It was measured by the Karl Fischer method (reference oil and fat analysis test method 2.1.3.4-2013).
[Hue]
The measurement was performed using a Robibond colorimeter (Robibond colorimeter F-type measuring instrument, manufactured by Robibond Co., Ltd.) (reference oil and fat analysis test method 2.2.1.1-2013). Y represents yellow and R represents red, and the larger the value, the more colored. A 133.4 mm cell was used for the measurement.
[Acid value]
The measurement was carried out according to the standard fat and oil analysis test method (2.3.1-2013). The higher the number, the more free fatty acids.
[Iodine value]
It was measured by the Wyeth-cyclohexane method (reference oil and fat analysis test method 2.3.4.1-2013). The larger the value, the more unsaturated bonds of fatty acids constituting fats and oils.
[Refractive index]
The measurement was carried out according to the standard fat analysis test method (2.2.3-2013). The measurement temperature is 25 ° C.
[Peroxide value]
It was measured by the acetic acid-isooctane method (reference oil and fat analysis test method 2.5.2.1-2013).
[Tocopherol]
Measurements were made using high performance liquid chromatography using an internal standard substance (2,2,5,7,8-Pentamethyl-6-Hydroxychroman; PMC) (reference oil and fat analysis test method 2.4.10-2013).

Comparative Example 1
Canola oil (manufactured by Tsuji Oil Co., Ltd.) was used as the test fat and oil. This test oil was produced by the method shown in FIG. Specifically, the oil / fat raw material A becomes crude oil B through the pressing step 1 and the extraction step 2, and the crude oil B is refined through the degumming step 3, the deoxidizing step 4, the decoloring step 5, and the deodorizing step 6. Oil C'was obtained. The fat and oil C'was obtained without adding the deodorizing distillate as in Example 1. The characteristics of the test fats and oils are also shown in Table 2.

Comparative Example 2
A γ-Toc preparation (manufactured by Mitsubishi Chemical Foods Co., Ltd., Gamma Bright (registered trademark) 90 (d-γ-tocopherol 90% or more)) is added to the test fat and oil of Comparative Example 1 to be 0.354% by mass as a whole. Was added. The characteristics of the test fats and oils are also shown in Table 2.

As shown in Table 2, the test fats and oils of Example 1 were three times or more (about 10 times in Table 2) as compared with the test fats and oils of Comparative Example 1 produced by a method without adding a deodorizing distillate. Tocopherol was included. On the other hand, the Toc composition, that is, the content of each of the Toc homologues with respect to the total Toc content was substantially the same as that of the test fat and oil of Comparative Example 1, and γ-Toc was the most abundant component at about 66% by mass. This is because the production method of Example 1 does not add a Toc preparation in the production process, but recycles the deodorized distillate to bring out the natural Toc originally possessed by the plant (rapeseed). On the other hand, the test fats and oils of Comparative Example 2 were produced by separately adding a γ-Toc preparation, and the content of γ-Toc was about the same as that of the test fats and oils of Example 1. , Toc composition was significantly different.

<Continuous administration test>
Using normal SD rats (species: Slc: SD, supplier: Nippon SLC Co., Ltd., use: 6 weeks old, 15 males), promotion of sodium excretion by the test fats and oils of Examples and Comparative Examples The effect was evaluated. SD rats were fed a high-salt diet in which salt was added to the normal diet CE-2 (Nippon Claire Co., Ltd.) so that the final salt concentration was 5 to 8%. From the 17th day of the test, the salt concentration in the feed was switched from 5% to 8%. Five rats in each test oil / fat administration group were orally administered continuously (10 ml / kg / day) for 22 days. Urine volume and total urinary sodium excretion were measured every week after administration. Regarding the measurement of urine volume, a metabolic cage (Nihon Techno Co., Ltd.) was used to collect urine for 24 hours, and the urine volume was measured. The measurement results of the urine volume in each administration group are shown in FIG. 4, and the measurement results of the total urinary sodium excretion are shown in FIG.

As shown in FIG. 4, the administration groups of Comparative Example 2 and Example 1 tended to have a larger urine volume than the administration group of Comparative Example 1, and the urine volume increased significantly on the 15th day after the administration.

As shown in FIG. 5, the total urinary sodium excretion in the administration group of Example 1 was significantly increased as compared with the administration group of Comparative Example 1. In addition, the total urinary sodium excretion tended to be higher in the administration group of Example 1 than in the administration group of Comparative Example 2 in which only the γ-Toc content was increased. From this result, it was found that the tocopherol content in fats and oils is involved in the expression of sodium excretion promoting action. Furthermore, it is possible to obtain a higher effect when the Toc composition is equivalent to that of general canola oil, that is, the Toc composition is close to the Toc composition derived from natural rapeseed, rather than the fat and oil simply containing a large amount of γ-Toc. found.

Based on the results of the above continuous administration test, the intake of γ-Toc required for the development of the sodium excretion promoting action is about 18 mg per day when converted into a human having a body weight of 60 kg. For example, when tonkatsu is fried and cooked using the edible oil and fat for promoting sodium excretion of the present invention, one tonkatsu (about 170 g) contains 7.8% (13.3 g) of the oil and fat, and the oil and fat contains 7.8% (13.3 g) of the oil and fat. Since the content of γ-Toc contained was 930 ppm, it is possible to ingest about 12 mg of γ-Toc by ingesting one pork cutlet. Therefore, it is quite possible to ingest an amount of γ-Toc that is expected to be effective in daily life. That is, by using the edible oil / fat for promoting sodium excretion of the present invention in a normal diet, the physiological action of γ-Toc (excretion action of excess salt) can be expected.

After completion of the above continuous administration test, rat livers were collected and the tocopherol content in the liver was analyzed. After weighing 5 livers in each administration group, the livers were placed in each group in a 140 mL glass bottle and cut into small pieces so as to be uniform. About 10 g of the uniformly cut liver was sampled in separate 140 mL glass bottles. After adding 30 g of sea sand, the liver was further cut with a glass rod. After drying at 105 ° C. for 4 hours (mixed after 2 hours of drying), the dry weight was measured. 30 mL of n-hexane was added to each dry sample, mixed well with a glass rod for 5 minutes, and the supernatant Misera was filtered. Tocopherol analysis using HPLC (fluorescence detector) was performed using 5 mL of Misera.

<Analysis conditions>
Column: Finepak SIL-5 (manufactured by JASCO Corporation, length 250 mm, inner diameter 4.6 mm)
Column temperature: 40 ° C
Wavelength: EX298nm / EM325nm
Solvent: n-hexane: isopropanol (500: 3)
Addition amount: 20 μL
Flow velocity: 1.0 mL / min

Based on the HPLC chromatogram obtained by the above analysis conditions, the content of each Toc in the rat liver was calculated from the peak showing α-Toc and the peak showing γ-Toc. The content of each Toc is shown in FIG.

In the Toc composition in the test fats and oils before administration, the content of γ-Toc was higher than that of α-Toc in all the test fats and oils (see FIG. 2), but the Toc composition in the liver tissue showed that. The ratio was reversed, and the content of α-Toc was significantly higher than that of γ-Toc in all administration groups (see FIG. 6). Furthermore, when compared between the administration groups, in α-Toc, the number was higher in the order of (Comparative Example 2) <(Comparative Example 1) <(Example 1). Further, in γ-Toc, the number was higher in the order of (Comparative Example 1) <(Example 1) <(Comparative Example 2).

In the following, the results of the continuous administration test will be considered based on the analysis results of Toc in the liver tissue. FIG. 7 shows a schematic diagram of the estimated pharmacokinetics of tocopherol homologues in the test fats and oils of Example 1 and Comparative Example 2.

In general, animals such as humans and rats are unable to synthesize tocopherols in their bodies and are all dependent on dietary tocopherols. Plants, unlike animals, can synthesize tocopherols, but in the process various Toc homologues are synthesized. In general, it is said that vegetable oil contains more γ-Toc than α-Toc. As shown in FIG. 7, when a plant is ingested by a human or a rat, the ingested Toc homologue is micellized by bile acids and then absorbed from the small intestine into the lymphatic vessels. The absorbed Toc homologues bind to chylomicrons, are converted to chylomicrons remnants, and then taken up by the liver. At this time, the Toc homologues have not been identified in the absorption and chylomicron-mediated secretion processes in the small intestine. That is, since both α-Toc and γ-Toc are transported to the liver without distinction, when a plant is ingested, the amount of Toc transported to the liver as an initial stage is larger in γ-Toc than in α-Toc. It will be.

The α-Toc transported to the liver selectively binds to the α-Toc transport protein (α-TTP) localized in the liver tissue, is released into the blood, and is transported to each tissue throughout the body. Toc homologues other than α-Toc have a weak affinity for α-TTP. By such a mechanism, α-Toc is selectively retained in the living body. On the other hand, in the liver, metabolism by cytochrome P450 in the liver is carried out in parallel with transportation by α-TTP. Each Toc homologue is metabolized by P450 to each (carboxyethyl hydroxychroman) CEHC.

Under the above mechanism, as shown in FIG. 6, the result that the content of α-Toc in the liver tissue was significantly higher than that of γ-Toc in any of the administration groups was that γ-Toc was cytochrome P450. It is considered that this was because it was preferentially metabolized to γ-CEHC. Further, as shown in FIG. 6A, the result that α-Toc was lower in Comparative Example 2 than in Comparative Example 1 was as large as in Comparative Example 2 to which γ-Toc was added. In the presence of γ-Toc, γ-Toc competitively binds to α-TTP in the liver and inhibits the binding of α-Toc to α-TTP, thereby binding α-Toc to α-CEHC. This is probably due to increased metabolism (Fig. 7 (b)).

Further, as shown in FIG. 6 (b), although the γ-Toc content of the test fat and oil was the same, the result of Example 1 was that the amount of γ-Toc in the liver was lower than that of Comparative Example 2. It became. In this regard, since the test fat and oil of Example 1 contains α-Toc 3 times or more (about 6 times) more than that of Comparative Example 2, α-Toc is efficiently contained in the liver as α-TTP. It is considered that γ-Toc was rapidly metabolized and the γ-Toc content decreased as well as binding to (Fig. 7 (a)). On the other hand, in Comparative Example 2, since the ratio of γ-Toc is much higher than that of α-Toc, γ-Toc competitively binds to α-TTP and the metabolism to γ-CEHC is delayed, so that γ-Toc is delayed. It is considered that the Toc content was relatively high (Fig. 7 (b)). As a result, it is considered that the production of γ-CEHC was increased in Example 1 as compared with Comparative Example 2, and the total sodium excretion amount was different as shown in FIG.

From the above, as in Comparative Example 2, the fat and oil to which only the γ-Toc preparation is added has an extremely increased proportion of γ-Toc, so that the amount of α-Toc having vitamin E activity absorbed into the body is reduced. , It is considered that the metabolism to α-CEHC increases and the metabolism from γ-Toc to γ-CEHC also decreases. On the other hand, vegetable oils containing Toc homologues in a well-balanced manner, such as the edible oils and fats of the present invention, increase the absorption of α-Toc into the body, suppress the metabolism to α-CEHC, and γ-CEHC. It is considered that the amount of production of can be increased. As described above, since the edible oil and fat of the present invention contains the Toc homologue in a well-balanced manner, metabolism to γ-CEHC is efficiently performed, and an excellent urinary sodium excretion promoting action can be exhibited.

Since the edible oil / fat for promoting sodium excretion of the present invention has a function of promoting the excretion of sodium, it can be widely used as a health-conscious household edible oil / fat. For example, it can be expected to be approved as a new physiological function application of edible oils and fats such as sodium excretion promoting function.

Claims (5)

It is an edible oil and fat for promoting sodium excretion that promotes sodium excretion.
The total content of tocopherols, including multiple homologues, is 1,000 ppm or greater.
An edible oil / fat for promoting sodium excretion, characterized in that the content of α-tocopherol is 10 to 40% by mass and the content of γ-tocopherol is 60 to 90% by mass in the total content of tocopherol. The edible oil / fat for promoting sodium excretion according to claim 1, wherein the total content of tocopherol is 6,000 ppm or less. The edible oil or fat for promoting sodium excretion according to claim 1 or 2, wherein the edible oil and fat and the tocopherol are derived from rapeseed or corn. The method for producing an edible oil or fat for promoting sodium excretion according to any one of claims 1 to 3.
The production method is a method of producing a raw material crude oil produced through at least one step of a pressing step and an extraction step through a degumming step, a deoxidizing step, a decoloring step, and a deodorizing step in order.
A method for producing an edible oil / fat for promoting sodium excretion, which comprises returning the deodorized distillate distilled in the deodorizing step to crude oil after the degumming step and before the deoxidizing step. The method for producing an edible oil or fat for promoting sodium excretion according to claim 4, wherein the production method does not include a step of adding a tocopherol preparation.