JP2020156971A - Medical solution delivery device and medical solution delivery method - Google Patents

Abstract

To provide a medical solution delivery device capable of repetitively delivering a prescribed amount of medical solution from a container filled with the medical solution to another container, while suppressing elution of foreign objects such as silicone oil in the medical solution.SOLUTION: A medical solution delivery device 1 comprises: a cylinder 2 having a nozzle 7 with a hole at one end and an opening 8 at the other end; and a piston 3 having a gasket 4 at a tip end and capable of sliding along an internal surface 12 of the cylinder 2 via the gasket, where a regulation part 5 is formed at any of the cylinder and the piston, for regulating a sliding range of the piston 3 heading for the nozzle from the opening.SELECTED DRAWING: Figure 1

Description

The present invention relates to a drug solution feeding device that feeds a certain amount of a drug solution from a container filled with the drug solution to another container.

Conventionally, when only the amount required for the time being is subdivided from a flexible packaging container filled with a chemical solution and transferred to another container, a certain amount is sucked up manually with a syringe or a certain amount with a syringe using a syringe pump or the like. It is widely practiced to transfer this to another container. The syringe has a simple structure in which a piston with a gasket made of rubber or the like attached to the tip is slid inside the cylindrical cylinder to facilitate suction, injection, and discharge of a certain amount of chemical solution. it can. Further, in order to maintain the airtightness of the gasket and the cylinder and to improve the slidability of the piston, silicone oil or a fluorine-based compound is often applied to the inner surface of the cylinder. However, when the chemical solution is sucked, the silicone oil or the like applied to the inner surface of the cylinder may be eluted into the chemical solution, and the chemical solution may be deteriorated.

On the other hand, for example, in Patent Document 1, by covering the tip of the gasket and the sliding surface with a PTFE film, good slidability can be obtained without applying silicone oil to the inner surface of the cylinder. Gaskets for are listed. Further, Patent Document 2 includes an inner cylinder capable of being compressed in a bellows shape inside a cylinder (outer cylinder), fills the inner cylinder with a chemical solution, and compresses the inner cylinder with a plunger. A chemical injection system for injecting and discharging a chemical solution is described.

Japanese Unexamined Patent Publication No. 2005-27831 International Publication No. 2011/125133

Both Patent Documents 1 and 2 assume a prefilled syringe filled with a certain amount of chemical solution in advance, and do not mention problems in the case of repeatedly sucking, injecting, and discharging the chemical solution. In the method of covering the tip of the gasket and the sliding surface with a sliding film, the film may generate dust and elute into the chemical solution when used repeatedly. Further, in the method of injecting and discharging the chemical solution by compressing the inner cylinder in a bellows shape, it is unclear whether a certain amount of the chemical solution can be sucked again in a short time after the chemical solution is injected and discharged. In any case, there is a need for a drug solution delivery device capable of repeatedly delivering a fixed amount of the drug solution while suppressing deterioration of the drug solution due to elution of silicone oil, film components, or the like.

The present disclosure has been made in view of such a situation, and a certain amount of the chemical solution is repeatedly transferred from the container filled with the chemical solution to another container while suppressing the elution of foreign substances such as silicone oil into the chemical solution. It is an object of the present invention to provide a chemical solution feeding device capable of transferring, and to provide a method for delivering a chemical solution using the chemical solution feeding device.

The chemical liquid delivery device according to the present embodiment has a cylinder having a nozzle portion having a hole at one end and an opening at the other end, and a gasket at the tip, via the gasket along the inner surface of the cylinder. A chemical liquid feeding device including a piston that can be slid by the cylinder, and restricts the sliding range of the piston from the opening toward the nozzle portion to either the cylinder or the piston. A regulatory department is formed.

Further, in the chemical liquid feeding device according to another embodiment of the present embodiment, the position of the piston closest to the one end in the sliding range is set as the first position, and the position of the piston farthest from the one end is set as the second position. The internal volume of the cylinder from one end to the end face of the gasket of the piston at the second position is the end face of the gasket of the piston from the one end at the first position. It may be less than twice the internal volume of the cylinder leading to.

The chemical liquid feeding device according to another embodiment of the present embodiment has a first liquid feeding portion having a first cylinder having a nozzle portion having a hole at one end and a first connecting portion having a hole at the other end. A second cylinder having a second connecting portion with a hole in the second cylinder and an opening at the other end and a gasket at the tip thereof can be slid along the inner side surface of the second cylinder via the gasket. A second liquid feeding unit having a similar piston, and a connecting pipe for connecting the first connecting portion of the first liquid feeding unit and the second connecting portion of the second liquid feeding unit. A regulating portion is formed in either the two cylinders or the piston to regulate the sliding range of the piston from the opening to the second connecting portion.

Further, the chemical liquid feeding apparatus according to another embodiment of the present embodiment has a first liquid feeding portion having a first cylinder having a nozzle portion having a hole at one end and a first connecting portion having a hole at the other end. A second cylinder having a second connecting portion with a hole at one end and an opening at the other end, and a gasket at the tip, and a constant sliding along the inner surface of the second cylinder through the gasket. A second liquid feeding part having a piston capable of sliding within a range, and the first connecting part of the first liquid feeding part and the second connecting part of the second liquid feeding part are connected. A connecting pipe is provided, and the connecting pipe is provided with a predetermined value for sliding the piston of the second liquid feeding unit to transfer the gas inside the second liquid feeding unit to the first liquid feeding unit. A filter that removes foreign matter is placed.

Further, in the chemical liquid feeding device according to another embodiment of the present embodiment, the position of the piston closest to the second connection portion side in the sliding range is set as the third position, and the position from the second connection portion side is the third position. When the position of the distant piston is set to the fourth position, the first cylinder, the connecting pipe, and the first cylinder extending from the one end of the first liquid feeding unit to the end surface of the gasket of the piston at the fourth position. The internal volume of the second cylinder is the first cylinder, the connecting pipe, and the second cylinder from the one end of the first liquid feeding unit to the end face of the gasket of the piston at the third position. It is less than twice the internal volume of the cylinder.

The method of supplying the chemical solution according to another embodiment of the present embodiment is a method of sending the chemical solution from the first container containing the chemical solution to a second flow path different from the first container. In the process of preparing the chemical solution feeding device, the first container containing the chemical solution and the liquid feeding device are connected by a delivery pipe via a flow path switching unit, and the first container is connected. Either a first flow path in which the drug solution can be transferred only between the container and the liquid transfer device, or a second flow path in which the drug solution can be transferred only between the liquid transfer device. Among the delivery pipe connecting steps and the sliding ranges that can be selected, the position of the piston closest to the second connecting portion side is set as the third position, and the position of the piston farthest from the second connecting portion side is set. When the position is set to the fourth position, the first flow path is selected, and the piston of the liquid feeding device is moved from a predetermined position between the third position and the fourth position to the fourth position. By sliding a predetermined amount toward the position of the above, a predetermined amount of the chemical solution is sent to the first liquid delivery portion of the chemical solution delivery device through the delivery pipe connected to the lower end of the first container. After the first liquid feeding step and the first liquid feeding step, the arrangement of the first container is changed so that the height of the liquid level of the chemical solution in the first container is lowered, and the first liquid feeding unit is used. After the second liquid feeding step of returning the excess chemical liquid sent to the container to the first container and the second liquid feeding step, the second flow path is selected and the chemical liquid feeding device is used. A third liquid feeding step of feeding a predetermined amount of a chemical solution to the second flow path by sliding the piston from a position where the piston is slid by a predetermined distance toward the third position is included. ..

According to the present embodiment, it is possible to repeatedly transfer a certain amount of the chemical solution from the container filled with the chemical solution to another container while suppressing the elution of foreign substances such as silicone oil into the chemical solution. It is possible to provide a liquid appliance and to provide a method for delivering a chemical solution using the chemical solution delivery device.

It is a perspective view explaining the structure of the liquid feeding device of 1st Embodiment. It is sectional drawing explaining the operation of the liquid feeding device of 1st Embodiment. It is a top view explaining the modification of the regulation part of the liquid feeding device of 1st Embodiment. It is a perspective view explaining the structure of the liquid feeding device of 2nd Embodiment. It is sectional drawing explaining the operation of the liquid feeding device of 2nd Embodiment. It is a perspective view explaining the structure of the liquid feeding device of 3rd Embodiment. It is sectional drawing explaining the operation of the liquid feeding device of 3rd Embodiment. It is sectional drawing explaining the operation of the liquid feeding device of 4th Embodiment. It is a schematic diagram explaining the structure and operation of the liquid feeding system of 5th Embodiment. It is another schematic diagram explaining the operation of the liquid feeding system of 5th Embodiment. It is another schematic diagram explaining the operation of the liquid feeding system of 5th Embodiment. It is a schematic diagram explaining the modification of the liquid feeding system of 5th Embodiment. It is a schematic diagram explaining another modification of the liquid feeding system of 5th Embodiment.

Hereinafter, an example of the chemical solution feeding device and the chemical solution feeding method of the present disclosure will be described with reference to the drawings and the like. However, the drug solution feeding device and the drug solution feeding method of the present disclosure are not limited to the embodiments and examples described below.

It should be noted that each figure shown below is schematically shown. Therefore, the size and shape of each part are exaggerated as appropriate to facilitate understanding. Further, in each drawing, hatching showing a cross section of the member is omitted as appropriate. Numerical values such as dimensions of each member and material names described in the present specification are examples of embodiments, and are not limited thereto, and can be appropriately selected and used. In the present specification, terms that specify shapes and geometric conditions, such as parallel, orthogonal, and vertical, are intended to include substantially the same state in addition to the exact meaning. Further, for convenience of explanation, the term “upper or lower” may be used for explanation, but the vertical direction may be reversed, and the same applies to the horizontal direction.

1. 1. First Embodiment The first embodiment of the chemical liquid delivery device of the present disclosure will be described. FIG. 1 is a perspective view showing an example of the chemical solution feeding device 1 of the present embodiment. FIG. 2 is a cross-sectional view showing the structure and operation of the chemical liquid feeding device 1 shown in FIG. FIG. 3 is a plan view showing a modified example of the shape of the regulation unit 5 in the present embodiment.

(A) Configuration of chemical liquid delivery device As shown in FIG. 1, the chemical liquid delivery device 1 has a syringe structure, and has a cylinder 2 having a cavity inside a substantially cylindrical outer cylinder portion and a cylinder 2 at the tip thereof. It has a piston 3 to which a gasket 4 is attached. The piston 3 is also called a pusher. A nozzle portion 7 having a small-diameter hole for sucking or discharging a chemical solution is formed at one end of the cylinder 2, and a wide flange is attached to the other end opposite to the one end. A cylinder opening 8 is formed.

The portion of the piston 3 to which the gasket 4 is attached is set at a position overlapping the cylinder opening 8, and the piston tip 6 which is the end of the piston 3 opposite to the gasket 4 is opened to the cylinder of the cylinder 2. The piston 3 can be inserted into the cylinder 2 by pushing in the direction from the portion 8 toward the nozzle portion 7. On the contrary, by pulling out the piston tip 6 from the nozzle 7 of the cylinder 2 toward the cylinder opening 8, the piston 3 can be discharged toward the outside of the cylinder 2.

When the piston 3 is inserted into the cylinder 2 or discharged to the outside, the gasket 4 maintains airtightness with respect to the second inner surface 12 which is the inner surface near the cylinder opening 8 of the cylinder 2. Moving. That is, the piston 3 slides inside the cylinder 2 via the gasket 4. Therefore, by moving the piston 3 of the chemical liquid feeding device 1 in the direction from the nozzle portion 7 toward the cylinder opening 8, the chemical liquid can be sucked into the cylinder 2 from the nozzle portion 7.

The cross-sectional shape of the cylinder 2 when cut on a plane perpendicular to the sliding direction of the piston 3 does not have to be circular, and as long as the piston 3 can slide, it is elliptical, oval, triangular, quadrangular, or many. It may be a quadrangle, or it may constitute an arbitrary figure connected by a straight line or a curved line.

On the other hand, in the hollow portion inside the cylinder 2, a regulating portion 5 that comes into contact with the second inner surface 12 which is the inner surface of the cylinder 2 is arranged. The regulating portion 5 is detachably or non-detachably fixed to the second inner side surface 12 of the cylinder 2, or is molded integrally with the cylinder 2. When viewed in the direction from the cylinder opening 8 toward the nozzle portion 7, the plan view of the regulation portion 5A, which is the regulation portion 5 of the present embodiment, has a hollow inside and an outer frame portion as shown in FIG. 3A. It has a shape having a ring portion 21 of.

The inner diameter of the ring portion 21 of the regulation portion 5A, which is the regulation portion 5, is smaller than the outer diameter of the gasket 4 of the piston 3. Therefore, when the piston 3 is inserted into the cylinder 2, the movement of the gasket 4, which is the tip of the piston 3, is restricted by the restricting portion 5 from the cylinder opening 8 toward the nozzle portion 7. That is, when the gasket 4 collides with the regulation portion 5, the piston 3 comes to the position closest to one end of the cylinder 2 having the nozzle portion 7. The position of the piston 3 at this time is set as the first position.

This time, on the contrary, when the piston 3 is moved so as to be discharged toward the outside of the cylinder 2, the gasket 4 which is the tip of the piston 3 has a second inner surface near the cylinder opening 8 as described later. The movement from the nozzle portion 7 toward the cylinder opening 8 is restricted at a portion where the inner diameter of the 12 is partially narrowed. That is, when the gasket 4 collides with a portion where the inner diameter of the second inner side surface 12 is partially narrowed, the piston 3 comes to the position farthest from one end of the cylinder 2 having the nozzle portion 7. The position of the piston 3 at this time is set as the second position.

By the way, when the piston 3 is further strongly moved so as to be discharged toward the outside of the cylinder 2, the gasket 4 gets over the portion where the inner diameter of the second inner side surface 12 is partially narrowed, so that the piston 3 becomes the cylinder 2. It is possible to move from one end of the to a position farther than the second position. In this case, the piston 3 is completely detached from the cylinder 2, and the cylinder 2 and the piston 3 of the chemical liquid feeding device 1 are separated.

The inner surface of the cylinder 2 can be divided into two sections with the regulation portion 5 fixed between them as a boundary. That is, of the inner side surface from one end of the cylinder 2 having the nozzle portion 7 to the other end of the cylinder 2 having the cylinder opening 8, the section including the contact portion with the regulating portion 5 from one end to the regulating portion 5. It has a first inner side surface 11, and has a second inner side surface 12 as a section extending from the regulating portion 5 to the other end and not including the contact portion of the regulating portion 5.

On the second inner surface 12 which is the actual sliding range of the piston 3, for example, silicone is used to reduce the frictional resistance between the gasket 4 and the second inner surface 12 and to ensure a good sliding operation of the piston 3. Oil or fluorine-based compounds can be applied.

On the other hand, the gasket 4 does not pass through the first inner side surface 11 which is outside the sliding range of the piston 3, but since it is a place where the chemical solution comes into contact when the chemical solution is sucked, silicone oil or fluorine-based No foreign matter, including compounds, should be applied.

(B) Operation and action of the drug solution delivery device Next, the operation and action of the drug solution delivery device 1 having the above structure will be described. FIG. 2 shows each opening of the cylinder opening 8 and the nozzle 7 when the cylinder 2 is viewed in the direction from the cylinder opening 8 of the cylinder 2 toward the nozzle 7 of the chemical liquid feeding device 1 shown in FIG. It is sectional drawing when the chemical liquid feeding apparatus 1 is cut in the plane passing through the center of.

The cylinder 2 is arranged so that the direction from the nozzle portion 7 to the cylinder opening 8 is upward and the opposite is downward. In the chemical liquid feeding device 1 of the present embodiment, the openings of both the cylinder opening 8 and the nozzle portion 7 are substantially circular, but the opening is not limited to this, and may be substantially elliptical or substantially polygonal. Further, the regulation portion 5 (5A) is fixed inside the cylinder 2.

Here, a plane perpendicular to the vertical direction passing through the end 7C of the nozzle portion 7 which is the lower end of the chemical liquid feeding device 1, a plane perpendicular to the vertical direction passing through the lower end of the regulating portion 5, and the first inside of the cylinder 2. The area surrounded by the side surface 11 is referred to as the first area 13. Further, as described above, the cylinder opening 8 which is the upper end of the cylinder 2 has a portion where the inner diameter of the second inner side surface 12 is partially narrowed, and the lower surface thereof is defined as the inner surface 8A of the inner convex portion. The upper surface is the inner convex outer surface 8B. At this time, it is surrounded by a plane perpendicular to the vertical direction passing through the upper end of the regulating portion 5, a plane perpendicular to the vertical direction passing through the outer surface 8B of the inner convex portion of the cylinder opening 8, and the second inner side surface 12 of the cylinder 2. The region is referred to as the second region 14.

First, as shown in FIG. 2A, by pushing the piston tip portion 6 of the piston 3 downward, the piston 3 can be pushed downward toward the cylinder 2. When the gasket 4 is lowered to the position where it collides with the regulation portion 5, that is, the first position, the piston 3 cannot be moved downward any more.

Next, after the nozzle portion 7 is immersed in the chemical solution 50, as shown in FIG. 2B, the piston tip portion 6 of the piston 3 is pulled upward to direct the piston 3 toward the upper side of the cylinder 2. Can be pulled up. However, when the upper surface of the gasket 4 rises to a position where it collides with the inner surface 8A of the inner convex portion of the cylinder opening 8, that is, to the second position, the piston 3 cannot be moved upward any more.

When the piston 3 moves from the first position to the second position, it slides through the gasket 4 while maintaining airtightness, so that the first region 13 of the cylinder 2 becomes a negative pressure with respect to the outside. The chemical solution 50 is sucked into the first region 13 from the nozzle portion 7, and the liquid level rises. Here, the internal volume of the cylinder 2 from the end 7C of the nozzle portion 7 to the lower end surface of the gasket 4 of the piston 3 at the first position is defined as V1. Further, the internal volume of the cylinder 2 from the end 7C of the nozzle portion 7 to the lower end surface of the gasket 4 of the piston 3 at the second position is defined as V2. At this time, assuming that the difference obtained by subtracting V1 from V2 is V3, V3 is the volume at which the gasket 4 when the piston 3 is moved from the first position to the second position crosses the second region 14, that is, the gasket. It means the volume obtained by multiplying the cross-sectional area of 4 by the amount of movement of the piston 3 in the vertical direction.

Here, when an extremely high pressure is not applied to the chemical solution, it is important to set V1 to be V3 or more, that is, to set V2 to be twice or less of V1. With this setting, when the piston 3 is moved from the first position to the second position, the liquid level of the chemical liquid 50 sucked into the cylinder 2 exceeds the first region 13 of the regulation unit 5. It does not rise upwards.

Therefore, the liquid level of the chemical liquid 50 sucked into the first region 13 exists in the region below the regulation unit 5 unless the chemical liquid delivery device 1 is tilted. Therefore, even if silicone oil or a fluorine-based compound is applied to the second inner side surface 12 of the cylinder 2 of the second region 14 to improve the slidability of the piston 3, it comes into contact with the chemical solution 50. It is possible to suppress the risk of foreign matter elution into the chemical solution 50.

Further, as shown in FIG. 2C, when it is considered that the delivery pipe route from the nozzle portion 7 to the destination is changed to go to another container by switching the flow path switching portion (not shown), again. By pushing the piston tip portion 6 of the piston 3 downward, the chemical liquid 50 sucked into the first region 13 can be discharged toward another container via the nozzle portion 7.

In this way, in the chemical liquid feeding device 1 of the present embodiment, the regulating portion 5 is provided on the inner surface of the cylinder 2 so that the piston 3 can enter only halfway of the cylinder 2, and the piston by the regulating portion 5 is provided. The piston 3 can be moved to the first position, which is the limit position of the movement of 3. On the contrary, the piston 3 can be moved in the opposite direction to the second position, which is the limit position where the piston 3 comes out of the cylinder 2.

After moving the piston 3 to the first position, the container of the chemical solution 50 is arranged so that the chemical solution 50 can be sucked from the nozzle portion 7, and then the piston 3 is moved to the second position to obtain a predetermined amount. The chemical solution 50 can be sucked into the cylinder 2. Further, since the first inner side surface 11 of the first region 13 of the cylinder 2 into which the chemical liquid is sucked is a portion where the gasket 4 does not abut, silicone oil or a fluorine-based compound is not applied. Further, by switching the container connected first from the nozzle portion 7 to another container and then moving the piston 3 from the second position to the first position, the amount of the chemical solution 50 equivalent to the amount sucked is 50. Can be accurately directed to another container.

Since the chemical solution 50 sucked into the cylinder 2 and discharged to the outside does not come into contact with the silicone oil or the fluorine-based compound applied to the second inner side surface 12 of the cylinder 2, these foreign substances are inadvertently eluted into the chemical solution 50. The risk of doing so can be suppressed.

Further, in the above, the suction amount of the chemical solution at one time is uniquely determined by moving the piston 3 from the first position to the second position, but the limit position for moving the piston 3 is the second. It may be any position closer to the first position than the position. That is, it is not necessary to use the maximum suction amount per reciprocating movement of the piston 3 in the chemical liquid feeding device 1, and a suction amount smaller than this is arbitrarily determined and the liquid is repeatedly fed at that amount. You may. For example, the movement amount of the piston 3 may be determined with reference to the scale displayed on the cylinder 2.

On the other hand, in the chemical solution feeding device 1 of the present embodiment, when the liquid level of the original chemical solution container is arranged so as to be higher than the terminal 7C of the nozzle portion 7, the pressure applied to the chemical solution 50 is applied. Due to the increase, more drug solution may be sucked than the planned suction amount. Therefore, it is preferable to increase the ratio of V1 to V2, which is the above-mentioned volume. Regarding the setting of V1 and V2, it is necessary to consider the positional relationship between the liquid level of the original chemical solution container and the chemical solution delivery device 1 in the height direction, the cross-sectional area of the container and the cylinder 2, the density of the chemical solution, and the like.

(C) Deformation example of the regulation part of the chemical liquid delivery device The regulation part 5 of the chemical liquid delivery device 1 of the present embodiment is a flat surface when viewed in the direction from the cylinder opening 8 toward the nozzle portion 7 as described above. The figure is shown in FIG. 3 (a). That is, the regulation portion 5A has a shape in which an opening 22 having a constant inner diameter having a ring portion 21 which is an outer frame portion is formed. However, the regulating unit 5 may regulate the movement of the piston 3 so that the gasket 4 of the piston 3 does not advance beyond the specified position, and can suppress the rise of the chemical solution from below as much as possible.

Other modifications of the regulation unit 5 satisfying such conditions will be described below, but it goes without saying that various other forms can be used. For example, as shown in FIG. 3B, a convex portion 24 protruding toward the center with a width somewhat larger than that of the first inner side surface 11 and a concave portion 23 protruding toward the center with a width smaller than this are formed on the first inner side surface 11. Along the same, the regulation portion 5B may be repeatedly formed. Also in this case, although the shape is different from that of the regulation portion 5A, the opening 22 having a constant shape is formed in the center. By providing the recess 23 in this way, the flow rate of air passing through the regulating portion 5 between the first region 13 and the second region 14 of the cylinder 2 can be increased, and the resistance when the piston 3 slides can be increased. It can be reduced.

Further, as shown in FIG. 3C, the regulation portion 5C may be formed in which only the protrusions 25 at two positions from the first inner side surface 11 project toward the center. In this case, the flow rate of air passing through the regulating portion 5 between the first region 13 and the second region 14 of the cylinder 2 can be further increased, and the sliding of the piston 3 can be made smoother.

On the other hand, as shown in FIG. 3D, the regulating portion 5D may have a large number of openings 27 formed in the film-like member 26 that completely covers the cross section of the cylinder 2 from the first inner side surface 11. In this case, the durability of the regulating portion 5 is improved, and even if the gasket 4 of the piston 3 is repeatedly hit, it can be made difficult to be damaged.

Further, as shown in FIG. 3E, the regulation portion 5E may be formed by completely covering the cross section of the cylinder 2 from the first inner side surface 11 with the filter 28. In this case, if the filter 28 is a member that allows air to pass sufficiently and does not allow chemicals to pass through, the air resistance when the piston 3 slides can be reduced, and the durability as the regulating portion 5 can be reduced. Can also be improved. Further, even if the chemical solution tries to pass through the regulation unit 5 toward the second region 14 of the cylinder 2 due to high pressure, the filter 28 can suppress this. Therefore, contamination of the chemical solution due to contact with the silicone oil or the like applied to the second inner side surface of the second region can be effectively suppressed. Further, since foreign substances other than such a coated material, such as foreign substances in the air, are not allowed to pass through, it is effective from the viewpoint of maintaining the quality of the chemical solution.

Various members can be used as the filter 28. For example, cellulose acetate (CA), nylon, polyethylene, cellulose, glass fiber, and polyether having a pore size of 0.1 μm or more and less than 10 μm can be used. Cellulose (PES), PTFE, polypropylene, MCE, PVDF and the like can be used. This is because the insoluble fine particle test method for injections in the Japanese Pharmacopoeia stipulates fine particles having a particle size of 10 μm or more, and it is considered preferable that foreign substances having a particle size of at least 10 μm or more do not mix with the drug solution.

2. 2. Second Embodiment Next, the second embodiment of the chemical solution delivery device of the present disclosure will be described focusing on the difference from the chemical solution delivery device of the first embodiment. FIG. 4 is a perspective view showing an example of the chemical solution feeding device 1A of the present embodiment. FIG. 5 is a cross-sectional view showing the structure and operation of the chemical liquid feeding device 1A shown in FIG.

(A) Configuration of Chemical Solution Supply Device As shown in FIG. 4, the drug solution delivery device 1A has a syringe structure similar to that of the drug solution delivery device 1 of the first embodiment, and has a cavity inside a substantially cylindrical outer cylinder portion. It has a cylinder 2 having a cylinder 2 and a piston 3A having a gasket 4 attached to the tip thereof. A nozzle portion 7 is formed at one end of the cylinder 2, and a cylinder opening 8 is formed at the other end opposite to the one end.

The regulation portion 5 as in the first embodiment is not arranged inside the cylinder 2, and instead, the regulation portion 5F fixed to the piston 3A in the section from the gasket 4 of the piston 3A to the piston tip portion 6 is provided. Is provided. The regulation unit 5F is also included in the regulation unit 5 of the chemical liquid delivery device of the present disclosure. The regulating portion 5F is a ring-shaped member having a diameter larger than the inner diameter of the gap portion of the cylinder opening 8, and is fixed to the piston 3 in a detachable or non-detachable manner, or integrated with the piston 3A. It is molded into.

When the piston 3A is inserted into the cylinder 2, the movement of the gasket 4, which is the tip of the piston 3A, from the cylinder opening 8 to the nozzle 7 is restricted by the regulating portion 5F. That is, when the regulating portion 5F collides with the cylinder opening 8, the piston 3A comes to the position closest to one end of the cylinder 2 having the nozzle portion 7. The position of the piston 3A at this time is set as the first position.

This time, on the contrary, when the piston 3A is moved so as to be discharged toward the outside of the cylinder 2, the gasket 4 which is the tip of the piston 3A is in the vicinity of the cylinder opening 8 as described in the first embodiment. It collides with a portion where the inner diameter of the second inner side surface 12 is partially narrowed. At this time, the piston 3A comes to the position farthest from one end of the cylinder 2 having the nozzle portion 7, and the position of the piston 3A at this time is set as the second position.

Further, the inner surface of the cylinder 2 is not bounded by the regulation portion 5F as in the first embodiment, but can be divided into two sections. That is, a section from one end of the inner surface of the cylinder 2 having the nozzle portion 7 on the inner surface to the other end of the cylinder 2 having the cylinder opening 8 from one end to just before the position of the gasket 4 at the first position. The first inner side surface 11 is provided, and the second inner surface 12 is provided as a section from the position of the gasket 4 in the first position to the other end.

In order to reduce the frictional resistance between the gasket 4 and the second inner surface 12 on the second inner surface 12 of the cylinder 2, which is the actual sliding range of the piston 3A, and to ensure a good sliding operation of the piston 3A. For example, silicone oil or a fluorine-based compound can be applied. Further, although the gasket 4 does not pass through the first inner side surface 11 of the cylinder 2 which is outside the sliding range of the piston 3A, since it is a place where the chemical solution comes into contact when the chemical solution is sucked, silicone. No foreign matter, including oils and silicone compounds, should be applied.

(B) Operation and action of the drug solution delivery device Next, the operation and action of the drug solution delivery device 1A will be described. FIG. 5 is a cross-sectional view of the chemical liquid feeding device 1A from the same viewpoint as in FIG. The cylinder 2 is arranged so that the direction from the nozzle portion 7 to the cylinder opening 8 is upward and the opposite is downward.

First, as shown in FIG. 5A, by pushing the piston tip 6 of the piston 3 downward, the piston 3A can be pushed downward toward the cylinder 2. However, once the regulating portion 5F is lowered to the position where it collides with the cylinder opening 8, that is, the first position, the piston 3 cannot be moved downward any more.

Next, after the nozzle portion 7 is immersed in the chemical solution, the piston 3A is pulled upward toward the cylinder 2 by pulling the piston tip portion 6 of the piston 3 upward as shown in FIG. 5 (b). be able to. However, when the upper surface of the gasket 4 rises to the position where it collides with the inner surface 8A of the inner convex portion of the cylinder opening 8, that is, to the second position, the piston 3A cannot be moved upward any more.

Here, it passes through a plane perpendicular to the vertical direction passing through the end 7C of the nozzle portion 7, which is the lowermost end of the chemical liquid feeding device 1, and the boundary portion between the upper end of the first inner surface 11 and the lower end of the second inner surface 12. The area surrounded by the plane perpendicular to the vertical direction and the first inner side surface 11 of the cylinder 2 is defined as the first area 13. Further, as described above, the cylinder opening 8 which is the upper end of the cylinder 2 has a portion where the inner diameter of the second inner side surface 12 is partially narrowed, and the lower surface thereof is defined as the inner surface 8A of the inner convex portion. The upper surface is the inner convex outer surface 8B. At this time, a plane perpendicular to the vertical direction passing through the boundary between the upper end of the first inner surface 11 and the lower end of the second inner surface 12, and perpendicular to the vertical direction passing through the inner convex outer surface 8B of the cylinder opening 8. The area surrounded by the flat surface and the second inner side surface 12 of the cylinder 2 is referred to as the second area 14.

When the piston 3A moves from the first position to the second position, the chemical liquid 50 is sucked into the first region 13 from the nozzle portion 7, and the liquid level rises. Here, the relationship and the necessary conditions of the volumes V1, V2, and V3 described in the first embodiment also apply to the present embodiment.

Therefore, also in the present embodiment, the chemical solution 50 sucked into the first region 13 forms a boundary between the upper end of the first inner surface 11 and the lower end of the second inner surface 12 unless the chemical solution feeding device 1 is tilted. In addition, the chemical solution 50 is prevented from entering the second region 14. Therefore, even if silicone oil or a fluorine-based compound is applied to the second inner side surface 12 of the cylinder 2 of the second region 14 to improve the slidability of the piston 3A, it comes into contact with the chemical solution 50. It is possible to suppress the risk of foreign matter elution into the chemical solution 50.

Further, as shown in FIG. 5 (c), by pushing the piston tip portion 6 of the piston 3A downward again, the chemical liquid 50 sucked into the first region 13 is transferred to another container via the nozzle portion 7. It can be discharged toward.

As described above, also in the chemical liquid feeding device 1A of the present embodiment, the regulating portion 5F is provided in the middle portion of the piston 3A so that the piston 3A can enter only halfway of the cylinder 2, and the piston by the regulating portion 5F. The piston 3A can be moved to the first position, which is the limit position for the movement of the 3A. On the contrary, the piston 3A can be moved in the opposite direction to the second position, which is the limit position where the piston 3A comes out of the cylinder 2.

Further, also in the present embodiment, the chemical liquid 50 sucked into the cylinder 2 and discharged to the outside does not come into contact with the silicone oil or the fluorine-based compound applied to the second inner side surface of the cylinder 2, so that it is careless. The risk of these foreign substances elution into the chemical solution 50 can be suppressed. Further, in the present embodiment, since the regulation portion 5F is fixed to the piston 3A that can be removed from the cylinder 2, if the regulation portion 5F is detachable from the piston 3A or the mounting position can be adjusted. In the case of the structure, these attachment / detachment work and adjustment work can be easily performed, and further, since there is no possibility that the regulation unit 5F comes into contact with the chemical solution 50, the range of material selection of the regulation unit 5F can be expanded.

3. 3. Third Embodiment Next, a third embodiment of the chemical liquid delivery device of the present disclosure will be described. FIG. 6 is a perspective view showing an example of the chemical solution feeding device 1B of the present embodiment. FIG. 7 is a cross-sectional view showing the structure and operation of the chemical liquid feeding device 1B shown in FIG.

(A) Configuration of Chemical Solution Feeding Instrument As shown in FIG. 6, the chemical solution feeding device 1B has only a second liquid feeding unit 17 having a structure corresponding to the chemical solution feeding device 1 of the first embodiment and a cylinder structure. It is composed of a first liquid feeding unit 16 and a connecting pipe 15 connecting the two. The second liquid feeding unit 17 has a second cylinder 2B having a cavity inside a substantially cylindrical outer cylinder portion, and a piston 3 having a gasket 4 attached to the tip thereof. One end of the second cylinder 2B has a second connecting portion 7B having a small diameter hole, and the second cylinder 2B is connected to the connecting pipe 15 via the second connecting portion 7B. A cylinder opening 9 with a wide flange is formed at the other end opposite to the one end.

On the other hand, the first liquid feeding unit 16 is composed of a first cylinder 2A having a cavity inside a substantially cylindrical outer cylinder portion, and one end of the first cylinder 2A has a small diameter for sucking or discharging a chemical solution. A nozzle portion 7A, which is a protruding portion having a hole, is formed, and a first connecting portion 9C having a hole is provided at the other end opposite to the one end, and a first connecting portion 9C having a hole is formed through the first connecting portion 9C. 1 cylinder 2A is connected to the connecting pipe 15.

The attachment portion of the gasket 4 of the piston 3 of the second liquid feeding portion 17 is set at a position overlapping the cylinder opening 9, and the piston tip portion 6 which is the end portion of the piston 3 opposite to the side where the gasket 4 is located is the second. The piston 3 can be inserted into the second cylinder 2B by pushing in the direction from the cylinder opening 9 of the two cylinders 2B toward the second connecting portion 7B. On the contrary, by pulling out the piston tip 6 from the second connecting portion 7B of the cylinder 2 toward the cylinder opening 9, the piston 3 can be discharged toward the outside of the second cylinder 2B.

When the piston 3 is inserted into the cylinder 2 or discharged to the outside, the gasket 4 moves with respect to the second inner surface 12A, which is the entire inner surface of the second cylinder 2B, while maintaining airtightness. That is, the piston 3 slides inside the second cylinder 2B via the gasket 4. By moving the piston 3 of the chemical liquid feeding device 1B from the second connecting part 7B toward the cylinder opening 9, the inside of the first liquid feeding part 16 separated by the connecting pipe 15 is negative to the outside. It becomes pressure and the drug solution can be sucked.

When the piston 3 is inserted into the second cylinder 2B, the movement of the gasket 4, which is the tip of the piston 3, is restricted by the restricting portion 5 from the cylinder opening 9 toward the second connecting portion 7B. In this way, when the gasket 4 collides with the regulation portion 5, the piston 3 comes to the position closest to one end of the second cylinder 2B having the second connection portion 7B. The position of the piston 3 at this time is set as the third position. The regulating unit 5 does not necessarily have to be provided in the intermediate section from the second connecting portion 7B inside the second cylinder 2B to the cylinder opening 9, and means, for example, a state in which the regulating unit 5 is excluded in FIG. However, since the second connecting portion 7B of the second cylinder 2B itself has a tapered shape, the gasket 4 of the piston 3 comes into contact with the inner wall of the second cylinder 2B forming the second connecting portion 7B, and the piston 3 slides. May be a regulated structure. That is, in this case, the inner wall itself of the second cylinder 2B forming the second connecting portion 7B has the function of the regulating portion 5.

This time, on the contrary, when the piston 3 is moved so as to be discharged toward the outside of the second cylinder 2B, the gasket 4 which is the tip of the piston 3 has an inner diameter of the second inner side surface 12A near the cylinder opening 9. Is partially narrowed, the movement from the second connecting portion 7B toward the cylinder opening 9 is restricted. That is, when the gasket 4 collides with a portion where the inner diameter of the second inner side surface 12A is partially narrowed, the piston 3 comes to the position farthest from one end of the second cylinder 2B having the second connecting portion 7B. The position of the piston 3 at this time is set as the fourth position.

Incidentally, although it is the same as the first embodiment, when the piston 3 is further strongly moved so as to be discharged toward the outside of the second cylinder 2B, the inner diameter of the second inner side surface 12A of the gasket 4 is partially narrowed. The piston 3 can move to a position farther than the fourth position from one end of the second cylinder 2B having the second connecting portion 7B. In this case, the piston 3 is completely detached from the second cylinder 2B, and the second cylinder 2B of the chemical liquid feeding device 1B and the piston 3 are separated.

The frictional resistance between the gasket 4 and the second inner side surface 12A is reduced on the second inner side surface 12A of the second cylinder 2B, which is the actual sliding range of the piston 3, so that the piston 3 has a good sliding operation. In order to secure it, for example, silicone oil or a fluorine-based compound can be applied.

(B) Operation and action of the drug solution delivery device Next, the operation and action of the drug solution delivery device 1B having the above structure will be described. FIG. 7 shows the cylinder opening 9 and the second cylinder 2B when the second cylinder 2B is viewed in the direction from the cylinder opening 9 of the second cylinder 2B toward the second connecting portion 7B with respect to the chemical liquid feeding device 1B shown in FIG. 2 It is sectional drawing of the chemical liquid delivery device 1B when the chemical liquid delivery device 1B is cut on a plane passing through the center of each opening of the connection portion 7B.

FIG. 7 is a view in which the direction from the second connecting portion 7B of the second cylinder 2B toward the cylinder opening 9 is upward, and vice versa. Similarly, the first cylinder 2A is arranged so that the direction from the nozzle portion 7A to the first connecting portion 9C is upward and the opposite is downward. Also in the chemical solution feeding device 1B of the present embodiment, the openings of the cylinder opening 9, the second connecting portion 7B, the first connecting portion 9C and the nozzle portion 7A are substantially circular, but are not limited thereto. It may be a substantially elliptical shape or a substantially polygonal shape.

Further, as described above, the cross-sectional shape of the second cylinder 2B when cut on a plane perpendicular to the sliding direction of the piston 3 may be any shape other than a circle. In addition to this, the cross-sectional shape of the first cylinder 2A when the first cylinder 2A is cut along a plane perpendicular to the direction from the nozzle portion 7A to the first connecting portion 9C has an arbitrary shape as in the second cylinder 2B. It is not necessary to have the same cross-sectional shape along the direction from the nozzle portion 7A to the first connection portion 9C. This is because the first cylinder 2A is separated from the second cylinder 2B and the piston 3 does not slide, so that it is not necessary to keep the cross-sectional shape constant along the direction from the nozzle portion 7A to the first connecting portion 9C. ..

Therefore, for example, the cross section may be gradually or continuously reduced along the direction from the first connecting portion 9C of the first cylinder 2A toward the nozzle portion 7A. For example, it may have a substantially conical shape. As described above, if the first cylinder 2A is formed to be tapered from the first connecting portion 9C toward the nozzle portion 7A, the chemical liquid sucked into the first region 13A can be easily discharged.

Further, the cross section of the first cylinder 2A does not need to have the same shape and size as the cross section of the second cylinder 2B, and it is sufficient that the functions of suction and discharge of the chemical liquid can be secured. Therefore, for example, the measurement is performed on a scale. The inner diameter of the first region 13A in the cross section of the first cylinder 2A may be smaller than the inner diameter of the second region 14A in the cross section of the second cylinder 2B for ease of use, and conversely becomes larger in order to facilitate the storage of the chemical solution. You may be.

Here, in FIG. 7A, the internal region of the first cylinder 2A from the nozzle portion 7A at the lower end of the first liquid feeding portion 16 of the chemical liquid feeding device 1B to the first connecting portion 9C is defined as the first region 13A. .. Further, as described above, the cylinder opening 9 which is the upper end of the second cylinder 2B has a portion where the inner diameter of the second inner side surface 12 is partially narrowed, and the lower surface thereof is the inner convex portion inner surface 9A. The upper surface is the inner convex outer surface 9B. At this time, it is surrounded by a plane perpendicular to the vertical direction passing through the upper end of the regulating portion 5, a plane perpendicular to the vertical direction passing through the outer surface 9B of the inner convex portion of the cylinder opening 9, and the second inner side surface 12A of the cylinder 2. Let the region be the second region 14A.

First, as shown in FIG. 7A, by pushing the piston tip portion 6 of the piston 3 of the second liquid feeding portion 17 downward, the piston 3 can be pushed downward toward the lower side of the second cylinder 2B. However, once the gasket 4 is lowered to the position where it collides with the regulation portion 5, that is, the third position, the piston 3 cannot be moved downward any more.

Next, after the nozzle portion 7A of the first liquid feeding portion 16 is immersed in the chemical solution, the piston tip portion 6 of the piston 3 of the second liquid feeding portion 17 is pulled upward as shown in FIG. 7B. As a result, the piston 3 can be pulled up toward the upper side of the second cylinder 2B. However, when the upper surface of the gasket 4 rises to the position where it collides with the inner surface 9A of the inner convex portion of the cylinder opening 9, that is, to the fourth position, the piston 3 cannot be moved upward any more.

When the piston 3 moves from the third position to the fourth position, it slides through the gasket 4 while maintaining airtightness. Therefore, the second region 14A of the second cylinder 2B and the first region 13A of the first cylinder 2A connected to the second region 14A via the connecting pipe 15 become negative pressure, and the chemical solution 50 from the nozzle portion 7A becomes the first region 13A. The liquid level inside the first cylinder 2A rises as it is sucked into the inside. Here, the internal volume of the first cylinder 2A from the end 7C of the nozzle portion 7A of the first liquid feeding portion 16 to the lower end surface of the gasket 4 of the piston 3 of the second liquid feeding portion 17 at the third position. , The sum of the internal volume of the connecting pipe 15 and the internal volume of the second cylinder 2B is defined as V4.

Further, the internal volume and connection of the first cylinder 2A from the end 7C of the nozzle portion 7A of the first liquid feeding portion 16 to the lower end surface of the gasket 4 of the piston 3 of the second liquid feeding portion 17 at the fourth position. The sum of the internal volume of the pipe 15 and the internal volume of the second cylinder 2B is defined as V5. At this time, assuming that the difference obtained by subtracting V4 from V5 is V6, V6 is the volume at which the gasket 4 when the piston 3 is moved from the third position to the fourth position crosses the second region 14A, that is, the gasket. It means the volume obtained by multiplying the cross-sectional area of 4 by the amount of movement of the piston 3 in the vertical direction.

Here, when an extremely high pressure is not applied to the chemical solution, it is important to set V4 to be V6 or more, that is, to set V5 to be twice or less of V4. With this setting, when the piston 3 is moved from the third position to the fourth position, the liquid level of the chemical liquid 50 sucked into the first cylinder 2A of the first liquid feeding unit 16 becomes the first. 2 It does not rise to the liquid feeding unit 17.

Therefore, the liquid level of the chemical liquid 50 sucked into the first region 13A of the first cylinder 2A in the first liquid feeding unit 16 rises to the second liquid feeding unit 17 unless the chemical liquid feeding device 1B is tilted. There is no. Therefore, it is assumed that silicone oil or a fluorine compound is applied to the second inner side surface 12A of the second region 14A of the second cylinder 2B in the second liquid feeding unit 17 in order to improve the slidability of the piston 3. However, this does not come into contact with the chemical solution 50, and the risk of foreign matter elution into the chemical solution 50 can be suppressed. Further, since the first liquid feeding unit 16 and the second liquid feeding unit 17 have a structure in which a connecting pipe 15 of an arbitrary length is interposed and separated from each other, the length of the connecting pipe 15 can be changed. By adjusting as necessary, it is possible to enhance the safety of preventing foreign matter from being eluted into the chemical solution 50.

The material, length, flexibility, etc. of the connecting pipe 15 can be freely changed. For example, when the connecting pipe 15 is made of a flexible material, the first liquid feeding liquid is fed by appropriately bending the connecting pipe 15. The positional relationship between the unit 16 and the second liquid feeding unit 17 can be freely determined. From this, as long as the position of the first liquid feeding unit 16 is kept constant, the suction and discharging performance of the chemical liquid does not change even if the position of the second liquid feeding unit 17 is changed, and it can be freely adjusted according to the working mode. The arrangement of the second liquid feeding unit 17 can be set. Further, the first liquid feeding part 16 and the second liquid feeding part 17 are fixed in a predetermined positional relationship by using the connecting pipe 15 formed linearly or curvedly with an inflexible hard member. You can also connect. Further, the connecting pipe 15 may be non-removably connected to the first liquid feeding unit 16 or the second liquid feeding unit 17, or may be removably connected.

Further, as in the first embodiment, the suction amount of the chemical solution at one time is uniquely determined by moving the piston 3 from the third position to the fourth position, but the limit for moving the piston 3 The position may be any position closer to the fourth position than the third position. Further, the regulating portion 5 arranged inside the second cylinder 2B of the second liquid feeding portion 17 is provided not only with a function as a stopper of the piston 3 but also with a filter function for preventing foreign matter from passing through. Good things are also common to the first embodiment.

4. Fourth Embodiment Next, although similar to the third embodiment, the fourth embodiment of the drug solution delivery device of the present disclosure will be mainly described mainly focusing on the differences from the third embodiment. FIG. 8 is a cross-sectional view taken in the same manner as in FIG. 7, showing an example of the chemical solution feeding device 1C of the present embodiment.

(A) Configuration of Chemical Solution Supply Device As shown in FIG. 8, the drug solution delivery device 1C has a structure similar to that of the drug solution delivery device 1B of the third embodiment, and the chemical solution delivery device 1 of the first embodiment has a similar structure. It is composed of a second liquid feeding unit 17 having a corresponding structure, a first liquid feeding unit 16 having only a cylinder structure, and a connecting pipe 15 connecting the two. The difference from the third embodiment is that the regulation unit is not arranged in the second liquid supply unit 17, and the connecting pipe connecting the first liquid supply unit 16 and the second liquid supply unit 17 has a filter structure. Is to have.

(B) Operation and action of the drug solution delivery device The operation and action of the drug solution delivery device 1C will be described. First, as shown in FIG. 8A, by pushing the piston tip portion 6 of the piston 3 of the second liquid feeding portion 17 downward, the piston 3 can be pushed downward toward the lower side of the second cylinder 2B. In the present embodiment, unlike the third embodiment, the regulating portion is not provided, so that the gasket 4 can move to the lower end position without colliding with the regulating portion on the way. In the present embodiment, this position is set as the third position.

Next, after the nozzle portion 7A of the first liquid feeding portion 16 is immersed in the chemical solution, the piston tip portion 6 of the piston 3 of the second liquid feeding portion 17 is pulled upward as shown in FIG. 8 (b). As a result, the piston 3 can be pulled up toward the upper side of the second cylinder 2B. However, the third point is that when the upper surface of the gasket 4 rises to the position where it collides with the inner surface 9A of the inner convex portion of the cylinder opening 9, that is, to the fourth position, the piston 3 cannot be moved upward any more. It is the same as the embodiment.

When the piston 3 moves from the third position to the fourth position, the chemical liquid 50 is sucked into the first region 13A from the nozzle portion 7A, and the liquid level inside the first cylinder 2A rises. The relationship of volumes V4, V5 and V6 described in the third embodiment is applied in exactly the same manner in this embodiment.

As shown in FIG. 7B, after sucking a certain amount of the chemical solution 50 into the first region 13A of the first liquid feeding unit 16, as shown in FIG. 7C, the piston tip portion of the piston 3 is again used. By pushing the 6 downward, the chemical liquid 50 sucked into the first region 13A of the first liquid feeding unit 16 can be discharged toward another container via the nozzle unit 7A.

At this time, the filter unit 60 that also serves as a connecting pipe that connects the first liquid feeding unit 16 and the second liquid feeding unit 17 is the first connecting portion 9C and the second liquid feeding unit 16 of the first liquid feeding unit 16. It is connected to the second connecting portion 7B of the portion 17, and the gas is transferred through a filter having a predetermined pore size. The pore size is, for example, 0.1 μm or more and less than 10 μm. By pushing the piston tip 6 of the piston 3 downward and pushing the air stored in the second region 14A of the second liquid feeding unit 17 into the first region 13A of the first liquid feeding unit 16, the first liquid feeding unit The chemical solution 50 sucked into the first region 13A of 16 can be discharged toward another container via the nozzle portion 7A. Here, since the air that pushes out the chemical solution 50 in the first region 13A of the first liquid feeding unit 16 has passed through the filter of the filter unit 60, for example, harmful foreign substances of 10 μm or more are removed.

Therefore, by any chance, the components of the gasket 4 or the second cylinder 2B may come off due to sliding between the second cylinder 2B of the second liquid feeding unit 17 and the gasket 4 of the piston 3, and the first liquid feeding unit Even if it is transferred together with air toward 16, the filter unit 60 is surely removed by the built-in filter. Therefore, the risk of such foreign matter mixing with the chemical solution 50 can be reduced as much as possible.

The structure of the filter unit 60 will be described with reference to FIG. 8 (d). FIG. 8D is a cross-sectional view taken along a plane passing through the central axis of the upper and lower openings of the filter unit 60. The filter unit 60 includes a third connecting portion 63 and a fourth connecting portion 64 having an opening as a connecting portion for connecting to an external delivery pipe or the like. Further, a filter case 62 is provided in order to impart a protective function of the filter 61 and airtightness to gas and liquid. As the filter 61, the same members as those exemplified for the filter 28 in the first embodiment described above can be used.

Such a structure is advantageous in that only the filter portion can be easily replaced or cleaned without affecting other configurations of the chemical liquid feeding device 1C. Further, depending on the chemical solution to be used and the required foreign matter removal performance, it is possible to appropriately change the conditions such as changing the pore size.

5. Fifth Embodiment Next, as a fifth embodiment, a liquid feeding method by a chemical liquid feeding system when the chemical liquid feeding device 1B of the third embodiment is used will be described. Needless to say, the chemical liquid feeding device used in the liquid feeding system can be similarly applied in any of the first, second and fourth embodiments. 9 to 11 are schematic schematic views illustrating the configuration of the chemical liquid feeding system of the fifth embodiment and the chemical liquid feeding method.

(A) Chemical Solution Feeding System FIG. 9 shows a schematic schematic diagram of the chemical solution feeding system 30 of the present disclosure. In this liquid feeding system 30, the first container 32 that is the source of the chemical liquid 50 is stored, the second container 33 that is the destination of the liquid to which the predetermined amount of the chemical liquid 50 is to be transferred, and the first container 32 that is the predetermined amount of the chemical liquid 50. It is composed of a chemical solution delivery device 31 (1B) for temporarily sucking the chemical solution 50 from the container 33 and then discharging the chemical solution 50 to the second container 33, and delivery pipes connecting each part. The delivery pipes include a first delivery pipe 34 that connects the first container 32 and the flow path switching portion 38, a second delivery pipe 35 that connects the flow path switching portion 38 and the second container 33, and a chemical liquid feeding liquid. At least a third delivery pipe 36 that connects the appliance 31 and the flow path switching portion 38 is provided.

The third delivery pipe 36 not only has a function of transferring the chemical solution 50 between the first container 32, the second container 33, and the chemical solution delivery device 31, but also has the first function of the first liquid delivery unit 16 of the chemical solution delivery device 31. May function as part of cylinder 2A. That is, the third delivery pipe 36 can function as an expanded capacity of the first region 13A by regarding it as a part of the capacity of the first region 13A of the chemical liquid feeding device 31. Therefore, by utilizing the third delivery pipe 36, it is possible to suck and discharge the chemical solution 50 larger than the capacity of the first region 13A of the chemical solution delivery device 31.

The flow path switching unit 38 is a so-called three-way stopcock, which is connected to three delivery pipes and selects two of them to activate the flow path. It may be switched by a manual handle or automatically by a solenoid valve or the like. Further, the flow path switching portion 38 may be a Y-shaped tube having no switching mechanism instead of a three-way stopcock. In this case, the flow path can be switched by adjusting the pressure in the delivery pipe connected to the Y-shaped pipe by pressing or releasing it from the outside.

As shown in FIG. 9, the first container 32 is connected to the first delivery pipe 34 at the bottom surface 39, which is the lower end thereof. As the member of the first container 32, any material having resistance to chemicals such as hard resin, soft resin, and glass can be used. Similarly, the second container 33 is also connected to the second delivery pipe 35 at the bottom surface 40, which is the lower end thereof. As for the member of the second container 33, any material can be used as in the case of the first container. The height at which the bottom surface 39 of the first container 32 and the bottom surface 40 of the second container 33 are arranged is as high as the lower end of the chemical liquid feeding device 31, that is, the lower end of the first cylinder 2A of the first liquid feeding unit 16. It is preferable to use. Moreover, it is preferable that the relationship between these heights is as constant as possible. If these heights fluctuate, there is a possibility that the chemical solution larger than the planned volume calculated from the movement amount of the piston 3 during the chemical liquid delivery or less than the planned volume may be sucked. This is because the amount needs to be corrected.

Further, as will be described later, the first container 32 preferably has a structure capable of turning the container upside down. The reversing operation may be performed automatically or manually. This is because it is necessary to return a part of the chemical solution that has been sucked too much into the chemical solution feeding device 31 to the first container 32.

(B) Method of supplying chemical solution First, as shown in FIG. 9, the above-mentioned chemical solution delivery device 31 is prepared. Further, this is connected to the first container 32 and the second container 33 via the flow path switching unit 38 by various delivery pipes as described above. This is referred to as a delivery pipe connection process. Further, the setting of the flow path switching unit 38 is switched so as to connect the first delivery pipe 34 and the third delivery pipe 36. Then, by pulling the piston 3 of the second liquid feeding unit 17 of the chemical liquid feeding device 31 upward from the third position, the piston 3 moves to the fourth position and stops. By this operation, from the bottom surface 39 at the lower end of the first container 32, the first liquid feeding part 16 of the chemical liquid feeding device 31 passes through the first delivery pipe 34, the flow path switching part 38, and the third delivery pipe 36. A predetermined amount of the chemical solution 50 is sucked into the inside of the 1 cylinder 2A. This is referred to as the first liquid feeding step.

It should be noted that the piston 3 may be pulled up to an arbitrary position between the third position and the fourth position and stopped without moving to the fourth position. This is because it may be desired to set the amount of one suction of the chemical solution to be smaller than the capacity of the first region 13A or the first cylinder 2A of the chemical solution delivery device 31. In this case, an arbitrary position may be determined by referring to, for example, a scale displayed on the side surface of the first cylinder 2A. Similarly, first, the piston 3 is not moved to the third position, but is stopped at an arbitrary position between the third position and the fourth position before the third position. May be good. That is, the suction start position and the suction end position of the chemical solution 50 of the piston 3 are determined not as the third position and the fourth position, but as arbitrary two positions between the third position and the fourth position, respectively. You may. In this case, any two positions can be determined with reference to the scale or the like displayed on the side surface of the first cylinder 2A as described above.

Next, as shown in FIG. 10, the first container 32 is turned upside down. As a result, the bottom surface 39 of the first container 32 is arranged at the uppermost portion. Further, the bottom surface 39 is arranged at a height below the lower end of the chemical liquid feeding device 31, that is, the lower end of the first cylinder 2A of the first liquid feeding unit 16. By this operation, the excess chemical solution 50 sucked excessively due to the liquid level of the chemical solution 50 being arranged at a high position with respect to the chemical solution delivery device 31, the third delivery pipe 36 and the first delivery pipe again. The 34 flows back and returns to the first container. This is referred to as a second liquid feeding step.

In FIG. 10, when the first container 32 is in the first container position 42, the chemical liquid 50 flowing from the bottom surface 39 of the first container 32 into the first delivery pipe 34 is subjected to the pushing pressure due to the weight of the chemical liquid 50 itself. In the chemical liquid feeding device 31, the chemical liquid 50 having a volume equal to or larger than the volume corresponding to the raised piston 3 of the second liquid feeding unit 17 enters the inside of the first cylinder 2A of the first liquid feeding unit 16. Due to the pressure of the chemical solution 50, the air inside the first cylinder 2A of the first liquid supply unit 16 and the inside of the second cylinder 2B of the second liquid supply unit 17 is compressed, and the chemical solution 50 enters by that amount. Is. Further, the delivery pipe and the cylinder may be slightly expanded by the pressure of the chemical solution, so that the excess chemical solution 50 may also enter.

Here, when the first container 32 is set to the second container position 43, that is, when the bottom surface 39 of the first container 32 is inverted and moved so as to come to the upper end, the chemical liquid 50 flowing through the first delivery pipe 34 The pressure is reduced by releasing the pressure due to its own weight, and the chemical liquid 50 that has excessively entered the inside of the first cylinder 2A of the first liquid feeding unit 16 flows back through the first delivery pipe 34 and returns to the first container 32. .. As a result, in the inside of the first cylinder 2A of the first liquid feeding unit 16, a chemical liquid 50 having a correct volume corresponding to the amount of increase of the piston 3 of the second liquid feeding unit 17 can be stored.

When the first container 32 is in the second container position 43, the bottom surface 39 is preferably at least the height of the lower end of the first liquid feeding portion 16 of the chemical liquid feeding device 31, that is, the height of the nozzle portion 7A or less. By ensuring that the liquid level of the chemical liquid 50 inside the first container 32 is lower than the liquid level of the chemical liquid 50 in the first liquid feeding portion of the chemical liquid feeding device 31, the chemical liquid 50 that has entered the surplus can be removed. This is because it can be satisfactorily returned to the first container 32.

In this way, after transferring a predetermined amount of the chemical solution 50 from the first container 32 of the transfer source of the chemical solution 50 to the chemical solution delivery device 31 via the delivery pipe, the first container 32 is turned upside down, etc. By lowering the liquid level position, the pressure of the chemical solution 50 in the first container 32 is reduced, and the surplus chemical solution 50 sucked into the chemical solution delivery device 31 is back-fed to the first container 32 to return the chemical solution delivery device 31. The method of appropriately correcting the suction amount of the chemical solution 50 to the drug solution 50 can be applied even when the chemical solution delivery device 31 is not used. That is, even if the chemical solution feeding device 31 is replaced with a normal syringe capable of sucking the chemical solution into the sliding range of the piston of the cylinder, the appropriate amount of the chemical solution can be transferred by the method of transferring the chemical solution. It will be possible.

Next, as shown in FIG. 11, the flow path switching unit 38 is set by disconnecting the connection between the first delivery pipe 34 and the third delivery pipe 36 and connecting the third delivery pipe 36 and the second delivery pipe 35. Switch to. After switching the setting of the flow path switching unit 38, the position of the first container 32 may be returned to the first container position 42, or the position of the second container 43 may remain. Then, by pushing the piston 3 of the second liquid feeding unit 17 of the chemical liquid feeding device 31 downward, the piston 3 moves from the fourth position to the third position and stops.

At the third position, the gasket 4 at the tip of the piston 3 is in contact with the regulating portion 5 fixed inside the second cylinder 2B of the second liquid feeding portion 17. By this operation, a predetermined amount of the chemical solution 50 sucked and stored inside the first cylinder 2A of the first liquid supply section 16 of the chemical solution delivery device 31 is supplied to the third delivery pipe 36, the flow path switching section 38, and the second. It is discharged from the bottom surface 40 at the lower end of the second container 33 to the inside of the second container 33 via the delivery pipe 35. This is referred to as a third liquid feeding step.

Through the above steps, a predetermined amount of the chemical solution 50 stored in the first container 32 can be temporarily sucked by the chemical solution delivery device 31 and sent to the second container 33, which is a separate container. In particular, with respect to the chemical solution 50 once sent to the chemical solution delivery device 31 in the first liquid delivery step, a second liquid delivery step is added in which the excess liquid transfer amount due to the weight of the chemical solution in the first container 32 is returned to the first container 32. This makes it possible to deliver an accurate amount of the chemical solution 50. Further, in the chemical liquid feeding device 31, the second liquid feeding unit 17 in which the sliding operation of the piston 3 is performed and the first liquid feeding unit 16 in which the chemical liquid 50 is sucked and discharged are separated by the connecting pipe 15. Therefore, the risk of foreign matter such as silicone oil applied to the first cylinder 2A being eluted into the chemical solution 50 in order to improve the slidability of the piston 3 can be reduced.

Further, if the regulating unit 5 that regulates the movement amount of the piston 3 fixed to the first cylinder 2A of the second liquid feeding unit 17 is provided with a filter function that does not allow foreign matter of a certain size or larger to pass through. It is also possible to suppress the elution of foreign substances such as dust generated from the gasket 4 when the piston 3 is sliding into the chemical solution 50.

Further, as described above, the chemical solution feeding device 31 may be replaced with the chemical solution feeding device 1C of the fourth embodiment. In this case, the second liquid feeding unit 17 has no regulating unit, and foreign matter of a certain size or larger is not passed through the connecting pipe 15 connecting the first liquid feeding unit 16 and the second liquid feeding unit 17. A filter unit 60 having a filter function is arranged. As a result, the elution of foreign substances that may occur in the second liquid feeding unit 17 into the chemical solution 50 can be effectively suppressed. Further, even if the suction amount of the chemical solution 50 from the first container 32 increases due to the high pressure and the chemical solution 50 tries to move from the first liquid feeding unit 16 to the second liquid feeding unit 17, the filter is concerned. If the pore size of the filter used in the unit 60 is set to an appropriate value, the chemical solution 50 cannot pass through the filter, and contamination due to an unintended overflow of the chemical solution can be prevented.

The initial state of the method for delivering the chemical solution of the present embodiment is that the inside of each delivery pipe of the first delivery pipe 34, the second delivery pipe 35, and the third delivery pipe 36 is previously filled with the chemical liquid 50. It corresponds to both the case and the case where the initial state is the state where the inside of each delivery pipe is filled with air. In the former case, almost no air intervenes in the delivery pipe connecting the first container 32, the chemical liquid feeding device 31 and the second container 33, and the air is compressed when the pressure of the chemical liquid 50 changes during liquid feeding. Since fluctuations in the amount of liquid to be sent due to expansion are suppressed, relatively stable liquid can be sent.

On the other hand, in the latter case, since it is not necessary to prepare each delivery pipe to fill the chemical solution 50 in advance, the solution can be quickly delivered with simple preparation. Basically, by shortening the length of each delivery pipe, it is possible to make it less susceptible to the influence of air compression and expansion due to the pressure change of the chemical solution 50 during liquid delivery. However, as in the present embodiment, by sandwiching the second liquid feeding step in which the first container 32 is turned upside down, the influence of air compression and expansion during such liquid feeding can be corrected, so that the delivery can be performed. Accurate liquid delivery is possible as if the inside of the tube was previously filled with the chemical solution 50.

Further, when the inside of the delivery pipe is filled with air, when the piston 3 of the chemical liquid delivery device 31 is pulled up to the fourth position, the chemical liquid 50 sucked from the first container 32 is at least the first delivery pipe. If it passes through 34 and flows to the third delivery pipe 36 side, even if not all the chemicals 50 are stored in the first region 13A of the chemicals delivery device 31, it goes to the second container 33 of the predetermined amount of the chemicals 50. It is possible to send the liquid. That is, even if most or all of the sucked chemical solution 50 is stored inside the third delivery pipe 36, the flow path is switched after the second liquid feeding step of turning the first container 32 upside down. By pushing down the piston 3 from the fourth position to the third position, a predetermined amount of the chemical solution 50 can be sent to the second container 33.

Further, according to another method when the inside of the delivery pipe is filled with air, the piston 3 of the chemical liquid feeding device 31 is once moved from the third position between the third position and the fourth position. It is also possible to pull up to the fifth position provided in the above to suck a predetermined amount of the chemical solution 50. At this time, the chemical solution 50 sucked from the first container 32 may reach the first region 13A of the chemical solution delivery device 31, and is stored inside the first delivery pipe 34 or the third delivery pipe 36. May be good.

After pulling up the piston 3 of the chemical liquid feeding device 31 to the fifth position, the surplus amount of the chemical liquid 50 stored in the delivery pipe is first subjected to the second liquid feeding step of turning the first container 32 upside down. After returning to the container 32, the piston 3 of the chemical liquid feeding device 31 is pulled up from the fifth position to the fourth position. As a result, all of the chemical liquid 50 stored inside the first delivery pipe 34 or the third delivery pipe 36 is sucked into the first region 13A of the chemical liquid delivery device 31, or is stored in at least the first delivery pipe 34. The chemical solution 50 is sucked into the first region 13A and the third delivery pipe 36 of the chemical solution delivery device 31. After that, by switching the flow path and pushing down the piston 3 of the chemical solution feeding device 31 from the fourth position to the fifth position, a predetermined amount of the chemical solution 50 can be sent to the second container 33.

In the fifth embodiment, the delivery pipes such as the first delivery pipe 34, the second delivery pipe 35 and the third delivery pipe 36, and the containers such as the first container 32 and the second container 33 are easy to dispose of. It is preferably made of resin. This also applies to the following modified examples.

(C) Modified example of the fifth embodiment (1)
Although the present embodiment has been described on the premise of the first container 32 and the second container 33, the second container 33 is not indispensable, and the chemical liquid feeding device is sent from the first container 32 to the second delivery pipe 35. A predetermined amount of the chemical solution 50 sucked by 31 may be sent. This is because the present embodiment is not necessarily limited to storing the chemical solution in a separate container.

For example, FIG. 12 shows a schematic schematic diagram of the chemical liquid feeding system 30A according to the modified example (1). As described above, in the liquid feeding system 30A, the chemical liquid 50 sucked by the chemical liquid feeding device 31 is transferred from the first container 32, which is the liquid feeding source in which the chemical liquid 50 is stored, to the second delivery pipe 35. The container 33 is not connected. In this case, the chemical solution 50 can be sequentially stored in a plurality of containers by receiving a predetermined amount of the chemical solution 50 flowing out from the tip portion 35A of the second delivery pipe 35 with individual saucers, sachets, or the like. In addition, it may be used as a method of not receiving it in a container.

(D) Modification example of the fifth embodiment (2)
Further, for the fifth embodiment, a further modification (2) as described below may be adopted. FIG. 13 shows a schematic schematic diagram of the chemical liquid feeding system 30B according to the modified example. The difference from the fifth embodiment of the liquid feeding system 30B is that the chemical liquid 50 flows into and out of the first container 32, which is the liquid feeding source, in addition to the bottom surface 39 and the top surface 41. Is to be provided. The fourth delivery pipe 37 connected to the top surface 41 side is connected to the first delivery pipe 34 connected to the bottom surface 39 side via the second flow path switching portion 38B, and the first delivery pipe 34 is further connected. It is also connected to the second delivery pipe 35 and the third delivery pipe 36 via the first flow path switching unit 38A. The first flow path switching unit 38A and the second flow path switching unit 38B are both three-way stopcocks, but as described above, they may be Y-shaped tubes having no switching mechanism.

In the case of this modification, first, the connection of the fourth delivery pipe 37 is disconnected, and the second flow path switching portion 38B is switched and connected so that the flow path between the first container 32 and the chemical liquid delivery device 31 is secured. .. Further, the first flow path switching unit 38A is switched and connected so as to secure the flow path between the first delivery pipe 34 and the third delivery pipe 36. Then, by pulling up the piston 3 of the second liquid feeding unit 17 of the chemical liquid feeding device 31 until it reaches the fourth position, the first delivery pipe 34 and the second are from the bottom surface 39 at the lower end of the first container 32. Inside the first cylinder 2A of the first liquid feeding part 16 of the chemical liquid feeding device 31 via the flow path switching part 38B, the first delivery pipe 34, the first flow path switching part 38A, and the third delivery pipe 36. A predetermined amount of the chemical solution 50 can be sucked. This is referred to as the first liquid feeding step. Needless to say, the pulling position of the piston 3 may be up to the fifth position in the middle as in the fifth embodiment.

Next, without turning the first container 32 upside down as in the fifth embodiment, the connection between the first delivery pipe 34 connected to the bottom surface 39 of the first container 32 is cut, and the fourth delivery pipe 37 and the first delivery pipe 37 are disconnected. 3 The second flow path switching unit 38B is switched and connected so that the flow path with the delivery pipe 36 is secured. Further, the position of the chemical liquid feeding device 31 is raised and moved from the original position of the lowering position 44 to the rising position 45. The ascending position 45 is preferably such that the lower end of the first liquid feeding portion 16 of the chemical liquid feeding device 31, that is, the height of the nozzle portion 7A is equal to or higher than the height of the top surface 41 of the first container 32. By ensuring that the liquid level of the chemical liquid 50 inside the first container 32 is lower than the liquid level of the chemical liquid 50 in the first liquid feeding portion of the chemical liquid feeding device 31, the chemical liquid 50 that has entered the surplus can be removed. This is because it can be satisfactorily returned to the first container 32.

As a result, as in the fifth embodiment, the excess chemical solution 50 sucked excessively due to the liquid level of the chemical solution 50 being arranged at a high position with respect to the chemical solution delivery device 31 is delivered again to the third delivery. The pipe 36 and the fourth delivery pipe 37 flow back and return to the first container. This is referred to as a second liquid feeding step.

Next, the setting of the first flow path switching unit 38A is switched so as to disconnect the first delivery pipe 34 and the third delivery pipe 36 and connect the third delivery pipe 36 and the second delivery pipe 35. Then, by pushing the piston 3 of the second liquid feeding unit 17 of the chemical liquid feeding device 31 downward, the piston 3 moves from the fourth position to the third position and stops. At the third position, the gasket 4 at the tip of the piston 3 is in contact with the regulating portion 5 fixed inside the second cylinder 2B of the second liquid feeding portion 17. By this operation, a predetermined amount of the chemical liquid 50 sucked and stored inside the first cylinder 2A of the first liquid feeding unit 16 of the chemical liquid feeding device 31 is supplied to the third delivery pipe 36, the first flow path switching unit 38A, and the first flow path switching unit 38A. It is discharged from the bottom surface 40 at the lower end of the second container 33 to the inside of the second container 33 via the second delivery pipe 35. This is referred to as a third liquid feeding step.

Through the above steps, as in the fifth embodiment, a predetermined amount of the chemical solution 50 stored in the first container 32 is temporarily sucked by the chemical solution delivery device 31, and the second container is a separate container. The liquid can be sent to 33. Similarly, the risk of foreign matter such as silicone oil being eluted into the chemical solution 50 can be reduced. Further, also in this modified example, as in the modified example (1), the configuration of the second container 33 is not essential, and any configuration may be sufficient as long as a predetermined amount of the chemical solution 50 can be transferred to the second delivery pipe 35.

Next, the present disclosure will be described in more detail with reference to examples, but the present disclosure is not limited to these examples.

A commercially available 1000 ml infusion bag made of a flexible resin material was used as the first container containing the chemical solution of the transfer source. As the second container, CryoMACS (registered trademark) Freezing Bag 50 manufactured by Miltenvi Biotec was used. Water was used as the chemical solution, and 2 ml of the solution was sent. As a chemical liquid delivery device, a nozzle of Terumo's syringe (20 ml, model: SS-20LZ) is fixed to a vent filter of Corning's closed system centrifuge tube (for 50 ml, filter pore size 0.2 μm). Was used. Further, as a delivery tube for connecting each device, a PVC tube having an inner diameter of 3 mm and a C-FLEX tube were used. The distance of the delivery pipe from the first container to the drug solution delivery device via the manual switching type three-way stopcock is 90 cm, and the distance of the delivery tube from the second container to the drug solution delivery device via the three-way stopcock is 90 cm. And said.

As the liquid feeding method, the chemical liquid feeding method of the fifth embodiment was carried out using the chemical liquid feeding device of the fourth embodiment. The initial state is a state in which the inside of each delivery pipe is filled with air. First, the first container is arranged so that the discharge port (bottom surface) faces downward, and the three-way stopcock is switched so that the first container and the first liquid feeding part of the chemical liquid feeding device are connected, and the second feeding The piston of the liquid part was pulled from the third position, which is the limit position for pushing, to the position where 2 ml is displayed before reaching the fourth position, which is the limit position for pulling up (corresponding to the fifth position described above). As a result, a predetermined amount of the chemical solution was sucked from the first container toward the first liquid delivery portion of the chemical solution delivery device. After that, by turning the first container upside down and turning the discharge port (bottom surface) upward, the water level of the first container is lowered and the water pressure is released, so that a part of the sucked chemical solution is the first container. It flowed back toward the surface and returned to the inside of the first container (corresponding to the above-mentioned second liquid feeding step).

After that, by further pulling up the piston toward the fourth position, all the chemicals remaining in the delivery pipe were sucked into the first liquid feeding section. At this time, the chemical solution was sent by pushing out the chemical solution with the air in the first container. After that, the three-way stopcock was switched so that the second container and the first liquid feeding part of the chemical liquid feeding device were connected, and the piston of the second liquid feeding part was pushed from the above-mentioned pulling position to the third position. As a result, all of the chemical liquid sucked into the first liquid feeding part of the chemical liquid feeding device is discharged toward the second container, and the same amount of chemical liquid as the amount sucked from the first container is discharged by the chemical liquid feeding device. It was possible to accurately deliver the specified predetermined amount to the second container.

Further, here, when the amount of the chemical solution contained in the first container is 500 ml and 100 ml, the liquid transfer is performed three times each, and the average of the actual liquid transfer amount is They were 1.964 ml and 1.967 ml, respectively, and there was almost no change in both. On the other hand, as a comparative example, when the amount of the chemical solution contained in the first container is 500 ml and 100 ml, the first container is turned upside down, the water level of the first container is lowered, and the water pressure is lowered. When the liquid was fed three times each without the operation of the second liquid feeding step to be released, the average actual liquid feeding amounts were 2.04 ml and 1.931 ml, respectively, and were stored in the first container. The result was that the amount of liquid sent varied depending on the amount of chemicals used. From this, after sucking a predetermined amount of the chemical solution from the first container toward the chemical solution feeding device, the first container is turned upside down, the water level of the first container is lowered, and the water pressure is released. By performing the operation of, the fluctuation of the suction amount due to the change in the hydraulic pressure due to the change in the chemical solution amount in the original first container is corrected, and the predetermined amount of the chemical solution is stably delivered regardless of the chemical solution amount in the first container. It was confirmed that a liquid was formed.

1, 1A, 1B, 1C Chemical solution delivery device 2 Cylinder 2A 1st cylinder 2B 2nd cylinder 3, 3A Piston 4 Gasket 5, 5A, 5B, 5C, 5D, 5E, 5F Regulatory part 6 Piston tip 7,7A Nozzle Part 7B Second connection part 7C End 8, 9 Cylinder opening 8A, 9A Inner convex part inner surface 8B, 9B Inner convex part outer surface 9C First connection part 11, 11A First inner side surface 12, 12A Second inner side surface 13, 13A 1st region 14, 14A 2nd region 15, 15A, 15B Connecting pipe 16 1st liquid feeding part 17 2nd liquid feeding part 21 Ring part 22 Opening 23 Recessed part 24 Convex part 25 Protrusion 26 Membrane-like member 27 Opening 28 Filter 30 30A, 30B Liquid feeding system 31 Chemical liquid feeding equipment 32, 32A 1st container 33 2nd container 34 1st delivery pipe 35 2nd delivery pipe 35A Tip 36 3rd delivery pipe 37 4th delivery pipe 38 Flow path switching part 38A 1st flow path switching part 38B 2nd flow path switching part 39 Bottom surface 40 Bottom surface 41 Top surface 42 1st container position 43 2nd container position 44 Lowering position 45 Ascending position 50 Chemical solution 60 Filter unit 61 Filter 62 Filter case 63 3rd connection Part 64 4th connection part

Claims (6)

A cylinder with a nozzle with a hole at one end and an opening at the other end,
A chemical liquid feeding device including a piston having a gasket at the tip thereof and capable of sliding along the inner surface of the cylinder via the gasket.
A chemical liquid feeding device in which a regulating portion for regulating the sliding range of the piston from the opening toward the nozzle portion is formed on either the cylinder or the piston. When the position of the piston closest to the one end is set as the first position and the position of the piston farthest from the one end is set as the second position in the sliding range.
The internal volume of the cylinder from one end to the end face of the gasket of the piston at the second position is the inside of the cylinder from one end to the end face of the gasket of the piston at the first position. The drug solution delivery device according to claim 1, which is not more than twice the volume of the above. A first liquid feeding unit having a first cylinder having a nozzle portion with a hole at one end and a first connecting portion with a hole at the other end.
A second cylinder having a second connecting portion with a hole at one end and an opening at the other end and a gasket at the tip can be slid along the inner surface of the second cylinder via the gasket. A second liquid feed unit with a possible piston, and
A connecting pipe for connecting the first connecting portion of the first liquid feeding portion and the second connecting portion of the second liquid feeding portion is provided.
A chemical liquid feeding device in which a regulating portion for regulating the sliding range of the piston from the opening toward the second connecting portion is formed in either the second cylinder or the piston. A first liquid feeding unit having a first cylinder having a nozzle portion with a hole at one end and a first connecting portion with a hole at the other end.
A second cylinder having a second connecting portion with a hole at one end and an opening at the other end, and a gasket at the tip, and a constant sliding range along the inner surface of the second cylinder via the gasket. A second liquid feed unit having a piston that can be slid with and
A connecting pipe for connecting the first connecting portion of the first liquid feeding portion and the second connecting portion of the second liquid feeding portion is provided.
In the connecting pipe, a filter for removing a predetermined foreign substance when the gas inside the second liquid feeding part is transferred to the first liquid feeding part by sliding the piston of the second liquid feeding part is provided. A chemical delivery device that is placed. When the position of the piston closest to the second connection portion side in the sliding range is set as the third position and the position of the piston farthest from the second connection portion side is set as the fourth position,
The internal volume of the first cylinder, the connecting pipe, and the second cylinder from one end of the first liquid feeding portion to the end surface of the gasket of the piston at the fourth position is the third. At the position of, the volume is not more than twice the internal volume of the first cylinder, the connecting pipe, and the second cylinder from one end of the first liquid feeding unit to the end surface of the gasket of the piston. Item 6. The chemical liquid feeding device according to Item 3 or 4. It is a method of sending a chemical solution from a first container containing a chemical solution to a second flow path different from the first container in a predetermined amount.
The chemical solution delivery device preparation step of preparing the drug solution delivery device according to any one of claims 3 to 5.
The first container containing the chemical solution and the chemical solution delivery device are connected by a delivery pipe via a flow path switching unit, and the chemical solution can be transferred only between the first container and the chemical solution delivery device. A delivery pipe connecting step, wherein either the first flow path or the second flow path capable of transferring the chemical solution only to the chemical solution delivery device can be selected.
When the position of the piston closest to the second connection portion side in the sliding range is set as the third position and the position of the piston farthest from the second connection portion side is set as the fourth position, the above-mentioned The first flow path is selected, and the piston of the chemical liquid feeding device is slid by a predetermined distance from a predetermined position between the third position and the fourth position toward the fourth position. The first liquid feeding step, in which a predetermined amount of chemical liquid is sent to the first liquid feeding portion of the chemical liquid feeding device through the delivery pipe connected to the lower end of the first container.
After the first liquid feeding step, the arrangement of the first container is changed so that the height of the liquid level of the chemical liquid in the first container is lowered, and the excess liquid sent to the first liquid feeding portion is changed. The second liquid feeding step of returning the chemical liquid to the first container, and
After the second liquid feeding step, the second flow path is selected, and the piston of the chemical liquid feeding device is slid from the position where the piston is slid by the predetermined distance toward the third position. A method for supplying a chemical solution, which comprises a third liquid feeding step of supplying a predetermined amount of the chemical solution to the second flow path.