JP2020110485A - Medicinal solution administration device - Google Patents

Abstract

To provide a medicinal solution administration device that reduces load on a subject.SOLUTION: A medicinal solution administration device includes one cannula, a sensor and a control unit. The cannula takes body fluid from a subject and injects medicinal solution supplied by a pump into the subject. The sensor measures an object substance contained in the taken body fluid. The control unit controls the pump to adjust an amount of the medicinal solution to be supplied to the cannula on the basis of a measurement result on the object substance by the sensor.SELECTED DRAWING: Figure 5

Description

Embodiments of the present invention relate to a drug solution administration device.

2. Description of the Related Art Conventionally, an insulin pump is known which is attached to a subject and continuously administers a drug solution such as insulin. In addition, a technique of controlling the dose of insulin by an insulin pump based on the measurement result of a sensor that measures the blood glucose level of the subject is also disclosed.

In such a conventional technique, a cannula for collecting blood to measure a blood glucose level and the like and a cannula for injecting insulin into a subject are separately provided. For this reason, a subject using such a device based on the related art has to insert a plurality of cannulas into his/her body, which may be a burden on the subject.

JP, 2017-113111, A JP, 2005-267364, A

The problem to be solved by the present invention is to provide a drug administration device that reduces the burden on the subject.

The drug solution administration device according to the embodiment includes one cannula, a sensor, and a controller. The cannula collects body fluid from the subject and injects the drug solution supplied from the pump into the subject. The sensor measures the target substance in the collected body fluid. The control unit controls the pump based on the measurement result of the target substance by the sensor to adjust the amount of the chemical liquid supplied to the cannula.

FIG. 1 is a diagram showing an example of an external appearance of a drug solution administration device according to the first embodiment. FIG. 2 is a diagram illustrating an example of mounting the drug solution administration device according to the first embodiment on a subject. FIG. 3 is a diagram illustrating details of an example of mounting the mounting unit according to the first embodiment on a subject. FIG. 4 is a diagram showing an example of the cannula according to the first embodiment. FIG. 5: is a block diagram which shows an example of a structure of the chemical|medical solution administration apparatus concerning 1st Embodiment. FIG. 6 is a diagram showing an example of an insulin administration standard database according to the first embodiment. FIG. 7 is a diagram showing an example of communication of the chemical liquid administration device according to the first embodiment with an external device. FIG. 8 is a flowchart showing an example of the flow of the blood glucose level measurement and insulin administration processing executed by the drug solution administration device according to the first embodiment. FIG. 9 is a flowchart showing an example of the flow of the dose determination process executed by the drug solution administration device according to the first embodiment. FIG. 10 is a block diagram showing an example of the configuration of the drug solution administration device according to the second embodiment. FIG. 11 is a flowchart showing an example of the flow of the blood glucose level measurement and insulin administration processing executed by the drug solution administration device according to the second embodiment. 12: is a figure which shows an example of the cannula concerning the modification 1. FIG. 13: is a figure which shows an example of the cannula concerning the modification 2. FIG.

Hereinafter, embodiments of a medical image processing apparatus and a medical image diagnostic apparatus will be described in detail with reference to the drawings.

(First embodiment)
FIG. 1 is a diagram showing an example of the external appearance of a drug solution administration device 1 according to the present embodiment. As shown in FIG. 1, the drug solution administration device 1 includes a main body portion 10, a mounting portion 20, and a cable 30 connecting the main body portion 10 and the mounting portion 20.

The main body 10 includes a display 12 and an input device 11. Further, the main body unit 10 has a function of an insulin pump that supplies insulin to the mounting unit 20 based on the blood glucose level measured by the blood glucose level sensor built in the mounting unit 20. Details of the configuration of the main body 10 will be described later.

The mounting unit 20 is a device mounted on the skin of the subject. The mounting part 20 includes one cannula 22 for collecting blood from the subject and injecting insulin into the subject. Insulin is supplied to the cannula 22 from a pump of the main body 10 described later. The mounting unit 20 also has a blood glucose level sensor, which will be described later, built therein.

Insulin is an example of the drug solution in the present embodiment. Blood is an example of body fluid in the present embodiment. The blood glucose level sensor is an example of the sensor according to this embodiment. Further, an example of the target substance in the present embodiment is glucose (glucose), and the blood glucose level sensor measures the glucose amount in 1 dL of blood, that is, the glucose concentration (blood glucose level) in blood.

The cable 30 is a cable that includes a tube that supplies insulin from the main body 10 to the cannula 22 of the mounting unit 20 and a transmission line that connects the main body 10 and the blood glucose level sensor in the mounting unit 20. The transmission path is, for example, a transmission path capable of data transmission conforming to a standard such as USB (Universal Serial Bus). The blood sugar level sensor transmits the blood sugar level measurement result to the main body unit 10 via the transmission path.

FIG. 2 is a diagram showing an example of how the drug solution administration device 1 according to the present embodiment is attached to the subject P. As shown in FIG. 2, the mounting portion 20 is mounted (fixed) on the epidermis of the subject P.

Further, the drug solution administration device 1 of the present embodiment is a portable drug solution administration device in which both the main body 10 and the mounting part 20 can be attached to the body of the subject P, the clothes 900, or the like. As an example, the main body 10 is provided with a grip such as a clip (not shown) on the back surface. The main body 10 can be attached (fixed) to the subject P by gripping the clothes 900 and the like of the subject P with the clip or the like. Alternatively, the main body 10 may include a belt or the like that can be fixed to the subject P. Further, the main body 10 may be stored in a pocket of the clothes 900 of the subject P or the like.

FIG. 3 is a diagram showing details of an example of mounting the mounting unit 20 on the subject P according to the present embodiment. As shown in FIG. 3, the mounting portion 20 includes an adhesive layer 201 on the surface in contact with the subject P, and by fixing the adhesive layer 201 to the epidermis of the subject P, the adhesive layer 201 is fixed to the epidermis of the subject P. Shall be done.

Further, when the mounting portion 20 is mounted on the epidermis of the subject P, the cannula 22 is in a state of being inserted and left in the subcutaneous tissue of the subject P as shown in FIG. 3. The cannula 22 is a tubular member made of a flexible material. Alternatively, a needle made of metal or the like may be used as the cannula 22.

The blood glucose level sensor 21 included in the mounting portion 20 measures the glucose concentration in the blood of the subject P collected by the cannula 22, that is, the blood glucose level. For example, the blood glucose level sensor 21 applies a voltage to the collected blood and measures the blood glucose level based on the generated current value. The method of measuring the blood glucose level is not limited to this, and a known method can be adopted. The blood sugar level sensor 21 transmits the blood sugar level measurement result to the main body 10 via the transmission path included in the cable 30.

Next, details of the structure of the cannula 22 in the present embodiment will be described. FIG. 4 is a sectional view showing an example of the cannula 22 according to the present embodiment. In the example shown in FIG. 4, the cannula 22 is placed under the skin of the subject P.

As shown in FIG. 4, the cannula 22 includes a first opening 221 for collecting blood from the subject P and a second opening 222 for injecting insulin into the subject P.

Further, the cannula 22 includes a first hollow portion 223 through which the collected blood passes and a second hollow portion 224 through which insulin supplied from the main body portion 10 through the tube in the cable 30 passes. The first opening 221 is connected to the first hollow portion 223, and the second opening 222 is connected to the second hollow portion 224.

In the present embodiment, the cannula 22 is assumed to suction the blood of the subject P from the first opening 221 by, for example, a capillary phenomenon. The blood sucked from the first opening 221 rises in the first hollow portion 223 due to the capillary phenomenon and reaches the blood glucose level sensor 21. In addition, a sensor element for measuring the blood glucose level may be provided in the first hollow portion 223. Further, the method of blood intake is not limited to this.

The first opening 221 and the second opening 222 are provided in different directions. For example, in the present embodiment, the first opening 221 is provided in a direction perpendicular to the skin of the subject P when the cannula 22 is placed under the skin of the subject P. The second opening 222 is provided so as to be parallel to the skin of the subject P when the cannula 22 is placed under the skin of the subject P.

Further, the length of the first hollow portion 223 and the length of the second hollow portion 224 are different. Since the first opening 221 is the end of the first hollow portion 223 and the second opening 222 is the end of the second hollow portion 224, the root of the cannula 22 (on the mounting portion 20 side). From the end) of the cannula 22 to the first opening 221 and from the root of the cannula 22 to the second opening 222.

In the present embodiment, the length of the first hollow portion 223 is longer than the length of the second hollow portion 224. Therefore, in the present embodiment, the first opening portion 221 which is the end portion of the first hollow portion 223 has a larger opening of the cannula 22 than the second opening portion 222 which is the end portion of the second hollow portion 224. It is provided near the tip. In this case, when the cannula 22 is inserted into the subject P, the first opening 221 collects blood from a position deeper than the position where insulin is injected through the second opening 222.

Next, details of the configuration of the drug solution administration device 1 will be described. FIG. 5: is a block diagram which shows an example of a structure of the chemical|medical solution administration apparatus 1 concerning this embodiment. As shown in FIG. 5, the drug solution administration device 1 includes a mounting portion 20 and a main body portion 10. The mounting unit 20 includes a blood glucose level sensor 21 and a cannula 22. Further, the main body 10 includes an input device 11, a display 12, an audio output device 13, an interface (I/F) circuit 14, a processing circuit 15, a storage circuit 16, and a pump 17.

The input device 11 has buttons, panel switches, or the like, receives various operations from the operator, and outputs the received various operations to the processing circuit 15. For example, the input device 11 receives a setting operation from the operator, an operation to start or end the process, and the like.

The display 12 displays the measurement result of the blood glucose level by the blood glucose sensor 21 or various alerts under the control of the processing circuit 15. The display 12 is an example of the display unit in the present embodiment.

The voice output device 13 outputs the measurement result of the blood glucose level by the blood glucose level sensor 21 or various alerts by sound or voice. The audio output device 13 is an example of an audio output unit in the present embodiment.

The alert displayed or output by the display 12 and the audio output device 13 is, for example, an alert notifying that the measurement result of the blood glucose level by the blood glucose sensor 21 is equal to or lower than the first threshold value or equal to or higher than the second threshold value. Details of the alert will be described later.

The interface circuit 14 is connected to the processing circuit 15 and controls wireless communication with an external device via a network such as the Internet. The interface circuit 14 is realized by a network card, a network adapter, a NIC (Network Interface Controller), or the like. The interface circuit 14 may communicate with an external device by short-range wireless communication such as WiFi (registered trademark), Bluetooth (registered trademark), or RFID (Radio Frequency Identification). The interface circuit 14 is an example of the communication unit in the present embodiment.

The pump 17 includes a syringe 173, a motor 172, and an actuator 171. Insulin is stored in the syringe 173 in advance. The syringe 173 is connected to the tube inside the cable 30. The syringe 173 includes a plunger (presser) not shown.

The insulin is discharged from the syringe 173 by applying a load to the plunger by the rotation of the motor 172. The insulin discharged from the syringe 173 is supplied to the cannula 22 via the tube in the cable 30, and is administered (injected) to the subject P from the second opening 222 via the second hollow portion 224. ..

The actuator 171 controls the amount of insulin discharged from the syringe 173 by controlling the rotation of the motor 172 under the control of the processing circuit 15. The configuration of the pump 17 is not limited to this, and known insulin pump technology can be applied.

The processing circuit 15 is an example of the control unit in the present embodiment, and controls the pump 17 based on the blood glucose level measurement result by the blood glucose level sensor 21 to adjust the amount of insulin supplied to the cannula 22.

More specifically, the processing circuit 15 includes an acquisition function 151, a determination function 152, a pump control function 153, an output function 154, and a transmission function 155.

The acquisition function 151 acquires the measurement result of the blood glucose level from the blood glucose level sensor 21 every predetermined time. The predetermined time is, for example, 5 minutes. The acquisition function 151 stores the acquired measurement result of the blood glucose level in the storage circuit 16 in association with the measurement time. In the present embodiment, the information in which the blood glucose level measurement result and the measurement time are associated is referred to as the blood glucose level measurement result history. Further, the acquisition function 151 sends the acquired measurement result of the blood glucose level to the determination function 152, the output function 154, and the transmission function 155.

The determination function 152 determines the amount of insulin to be administered to the subject P based on the blood glucose level measurement result acquired by the acquisition function 151. Further, the determination function 152 determines whether or not to output an alert and the content of the alert to be output, based on the blood glucose level measurement result acquired by the acquisition function 151. The determination process executed by the determination function 152 is referred to as a dose determination process.

More specifically, the determination function 152 determines the dose of insulin based on the result of comparison between the measurement result of the blood glucose level and the threshold value of the blood glucose level registered in the insulin administration reference database previously stored in the memory circuit 16. , Or determine the content of the alert.

FIG. 6 is a diagram showing an example of the insulin administration reference database 161 according to the present embodiment. As shown in FIG. 6, the insulin administration reference database 161 stores the blood glucose level, the dose of insulin, and the content of the output alert in association with each other. The dose of insulin is represented by the number of units based on “1 unit=0.01 mL”.

In the present embodiment, the blood glucose level is defined by being divided into first to sixth ranges, and the dose of insulin and the content of the output alert are associated with each of the first to sixth ranges. Shall be provided. In the example shown in FIG. 6, the first range is “79 mg/dL or less”, the second range is “80 mg/dL or more and 159 mg/dL or less”, and the third range is “160 mg/dL or more and 199 mg. /DL or less", the fourth range is "200 mg/dL or more and 249 mg/dL or less", the fifth range is "250 mg/dL or more and 350 mg/dL or less", and the sixth range is "351 mg/dL" Or more”.

The upper limit value of the first range “79 mg/dL or less” is an example of the first threshold value in the present embodiment. The lower limit value of the sixth range, "351 mg/dL or less," is an example of the second threshold value in the present embodiment.

For example, when the measured blood glucose level is equal to or lower than the first threshold value (“79 mg/dL”), the subject P may have low blood glucose, and therefore the determination function 152 uses the “instruction of intake of 5 g of glucose”. It is determined that the alert of "is output."

When the measured blood glucose level is equal to or higher than the second threshold value (“351 mg/dL”), the subject P is in a hyperglycemic state, and therefore the determination function 152 causes the subject P to be hyperglycemic. It is determined that the “hyperglycemia alert” indicating that the output is being output. In the present embodiment, the alert of “instruction of glucose 5 g intake” is the first alert, and the “hyperglycemia alert” is the second alert.

When the measured blood glucose level falls within the second range, the determination function 152 determines that insulin administration and alert output are not performed. If the measured blood glucose level falls within the third to fifth ranges, the determination function 152 determines that the subject P should be administered with the dose of insulin associated with each range. The blood glucose level, the insulin dose, and the content of the alert shown in FIG. 6 are examples, and the present invention is not limited to these.

When it is determined that insulin should be administered, the determination function 152 stores the determined insulin dose in the storage circuit 16 in association with the determination time, that is, the time when insulin is administered. In the present embodiment, the information in which the dose of insulin and the time at which insulin is administered are associated with each other is referred to as the history of the dose of insulin. The determination function 152 also sends the determined insulin dose to the pump control function 153 and the transmission function 155. When the determination function 152 determines to output the alert, the determination function 152 sends the content of the output alert to the output function 154 and the transmission function 155.

Returning to FIG. 5, the pump control function 153 sends a control signal to the actuator 171, and controls the pump 17 so that the amount of insulin determined by the determination function 152 is discharged from the syringe 173.

The output function 154 controls the display 12 and the audio output device 13. More specifically, the output function 154 causes the display 12 to display the measurement result of the blood glucose level acquired by the acquisition function 151. Further, the output function 154 causes the voice output device 13 to output the measurement result of the blood glucose level acquired by the acquisition function 151 by voice.

Further, when the determination function 152 determines that the alert is to be output, the output function 154 outputs the alert determined as the output target from the display 12 or the audio output device 13.

For example, when the determination function 152 determines that the determination function 152 outputs an alert of “instruction of intake of 5 g of glucose”, the output function 154 displays a character message “Please ingest 5 g of glucose” on the display 12. Further, the output function 154 may output a voice “Please ingest 5 g of glucose” from the voice output device 13. The output function 154 may output a warning sound from the voice output device 13 when the determination function 152 determines that the “hyperglycemia alert” is output.

Note that the output function 154 may output the blood glucose measurement result or the alert from one of the display 12 and the voice output device 13, or may cause both the display 12 and the voice output device 13 to output the blood glucose measurement result or the alert. May be output.

The transmission function 155 transmits via the interface circuit 14 the measurement result of the blood glucose level acquired by the acquisition function 151, the dose of insulin determined by the determination function 152, and various alerts determined to be output by the determination function 152. Send to device. The alert transmitted by the transmission function 155 is, for example, an alert notifying that the measurement result of the blood glucose level by the blood glucose sensor 21 is equal to or lower than the first threshold value or equal to or higher than the second threshold value.

FIG. 7 is a diagram showing an example of communication of the chemical liquid administration device 1 according to the present embodiment with an external device. The mobile terminal such as the smartphone 4 shown in FIG. 7, the electronic medical chart device 5, and the recording server device 6 are examples of external devices that are targets of communication with the drug solution administration device 1. It is assumed that the electronic medical chart device 5 is, for example, an electronic medical chart device of a hospital to which the subject P to which the drug solution administration device 1 is attached is subject. In addition, the recording server device 6 includes a database that stores the measurement result of the blood glucose level of the subject P and the history of the dose of insulin.

The transmission function 155 transmits the measurement result of the blood glucose level, the dose of insulin determined by the determination function 152, and various alerts determined to be output by the determination function 152 to these external devices via the network 7. The network 7 is the Internet or a local area network (LAN).

For example, when the subject P wearing the drug solution administration device 1 is a child, the transmission function 155 transmits various alerts determined to be output by the determination function 152 to the parent smartphone 4 of the subject P. Then, the state of the subject P may be notified. When the interface circuit 14 has a short-range wireless communication function such as WiFi (registered trademark), Bluetooth (registered trademark), or RFID, the transmission function 155 transmits various alerts to the smartphone 4 or the like by short-range wireless communication. You may do it.

The external device to be the communication target of the drug solution administration device 1 is not limited to the example shown in FIG. 7, and the drug solution administration device 1 may communicate with various wearable terminals, a PC (Personal Computer), or the like.

Returning to FIG. 5, the storage circuit 16 stores various information used in the processing circuit 15 in advance. As an example, the storage circuit 16 stores the insulin administration reference database 161. The storage circuit 16 also stores a history of blood glucose level measurement results and a history of insulin dose.

The storage circuit 16 is realized by, for example, a RAM (Random Access Memory), a semiconductor memory element such as a flash memory, a hard disk, an optical disk, or the like. The storage circuit 16 is an example of the storage unit in the present embodiment.

Here, for example, the acquisition function 151, the determination function 152, the pump control function 153, the output function 154, and the transmission function 155, which are the constituent elements of the processing circuit 15, are stored in the form of a program executable by a computer. It is stored in the circuit 16. The processing circuit 15 reads out each program from the storage circuit 16 and executes each read program to realize a function corresponding to each program. In other words, the processing circuit 15 in the state where each program is read out has each function shown in the processing circuit 15 of FIG. In FIG. 5, the single processing circuit 15 has been described as realizing each processing function of the acquisition function 151, the determination function 152, the pump control function 153, the output function 154, and the transmission function 155. Alternatively, the processing circuit 15 may be configured by combining a plurality of independent processors, and each processor may realize each processing function by executing each program.

The word "processor" used in the above description is, for example, a CPU (central preprocess unit), a GPU (Graphics Processing Unit), an application specific integrated circuit (ASIC), a programmable logic device (for example, It means a circuit such as a simple programmable logic device (SPLD), a complex programmable logic device (CPLD), and a field programmable gate array (FPGA). Instead of storing the program in the memory circuit 16, the program may be directly incorporated in the circuit of the processor. In this case, the processor realizes the function by reading and executing the program incorporated in the circuit.

Next, a flow of processing executed by the drug solution administration device 1 according to the present embodiment will be described. FIG. 8 is a flowchart showing an example of the flow of the blood glucose level measurement and insulin administration processing executed by the drug solution administration device 1 according to the present embodiment.

First, the acquisition function 151 acquires the measurement result of the blood glucose level from the blood glucose level sensor 21 (S1). Then, the acquisition function 151 stores the acquired measurement result of the blood glucose level in the storage circuit 16 in association with the measurement time (S2). Further, the acquisition function 151 sends the acquired measurement result of the blood glucose level to the determination function 152, the output function 154, and the transmission function 155.

Then, the output function 154 causes the display 12 to display the measurement result of the blood glucose level acquired by the acquisition function 151. Further, the output function 154 causes the voice output device 13 to output the measurement result of the blood glucose level acquired by the acquisition function 151 by voice (S3).

Then, the transmission function 155 transmits the blood glucose level measurement result acquired by the acquisition function 151 to the external device via the interface circuit 14 (S4).

Next, the determination function 152 executes a dose determination process (S5). Details of the dose determination process will be described with reference to FIG.

FIG. 9 is a flowchart showing an example of the flow of the dose determination process executed by the drug solution administration device 1 according to the present embodiment.

The determination function 152 compares the measurement result of the blood glucose level with the threshold value of the blood glucose level registered in the insulin administration reference database 161 stored in advance in the storage circuit 16. First, the determination function 152 determines whether or not the blood glucose level of the subject P corresponds to “0 to 79 (mg/dL)”, that is, the first range (S501). When the blood glucose level of the subject P falls within the first range, the blood glucose level of the subject P becomes equal to or lower than the first threshold value.

When the determination function 152 determines that the blood glucose level of the subject P falls within the first range (S501 “Yes”), it outputs a first alert, that is, an alert of “instruction of intake of 5 g of glucose”. (S502). In this case, the determination function 152 sends the output of the first alert to the output function 154 and the transmission function 155. Then, the output function 154 outputs the first alert from the display 12 or the audio output device 13. Further, the transmission function 155 transmits the first alert to the external device.

When the determination function 152 determines that the blood glucose level of the subject P does not fall within the first range (S501 “No”), the blood glucose level of the subject P is “80 to 159 (mg/dL)”, That is, it is determined whether or not it falls within the second range (S503).

When the determination function 152 determines that the blood glucose level of the subject P falls within the second range (S503 “Yes”), it determines not to administer insulin (S504). Further, in this case, the determination function 152 determines that no alert is output.

When the determination function 152 determines that the blood glucose level of the subject P does not fall within the second range (S503 “No”), the blood glucose level of the subject P is “160 to 199 (mg/dL)”, That is, it is determined whether or not it falls within the third range (S505).

When the determination function 152 determines that the blood glucose level of the subject P falls within the third range (S505 “Yes”), it determines that the insulin dose is “2 units” (S506). In this case, the determination function 152 sends the determined insulin dose to the pump control function 153 and the pump control function 153 and the transmission function 155.

Then, the pump control function 153 controls the pump 17 according to the dose of insulin determined by the determination function 152, and delivers the determined dose (“2 units” in this case) of insulin to the subject P. Administer (S507).

Further, the determination function 152 stores the determined insulin dose in the storage circuit 16 in association with the time at which insulin was administered (S508). The pump control function 153 may store the determined insulin dose in the storage circuit 16 in association with the time at which insulin was administered.

Then, the transmission function 155 transmits the dose of insulin determined by the determination function 152 to the external device (S509).

When the determination function 152 determines that the blood glucose level of the subject P does not fall within the third range (S505 “No”), the blood glucose level of the subject P is “200 to 249 (mg/dL)”, That is, it is determined whether or not it falls within the fourth range (S510).

When it is determined that the blood glucose level of the subject P falls within the fourth range (S510 “Yes”), the determination function 152 determines that the insulin dose is “4 units” (S511). In this case, the determination function 152 sends the determined insulin dose to the pump control function 153 and the pump control function 153 and the transmission function 155. After the processing of S511, the pump control function 153, the determination function 152, and the transmission function 155 execute the processing of S507 to S509.

When the determination function 152 determines that the blood glucose level of the subject P does not fall within the fourth range (S510 “No”), the blood glucose level of the subject P is “250 to 350 (mg/dL)”, That is, it is determined whether or not it falls within the fifth range (S512).

When it is determined that the blood glucose level of the subject P falls within the fifth range (S512 “Yes”), the determination function 152 determines that the insulin dose is “6 units” (S513). In this case, the determination function 152 sends the determined insulin dose to the pump control function 153 and the pump control function 153 and the transmission function 155. After the processing of S513, the pump control function 153, the determination function 152, and the transmission function 155 execute the processing of S507 to S509.

When the determination function 152 determines that the blood glucose level of the subject P does not fall within the fifth range (S512 “No”), the blood glucose level of the subject P is “250 (mg/dL)” or more, that is, It is determined that it falls within the sixth range. In this case, since the blood glucose level of the subject P becomes equal to or higher than the second threshold value, the determination function 152 determines to output the second alert, that is, the “hyperglycemia alert” (S514). In this case, the determination function 152 sends the output of the second alert to the output function 154 and the transmission function 155. Then, the output function 154 outputs the second alert from the display 12 or the audio output device 13. Further, the transmission function 155 transmits the second alert to the external device. Here, the processing of this flowchart ends, and the processing returns to FIG.

In the flowchart of FIG. 8, after the dose determination process of S5, the acquisition function 151 determines whether to end the process (S6). For example, the acquisition function 151 determines to end the process when the operation of ending the process of measuring the blood glucose level and administering the insulin is input from the input device 11 (S6 “Yes”). In this case, the process of this flowchart ends.

In addition, the acquisition function 151 determines not to end the process when the end operation of the process is not input from the input device 11 (S6 “No”). In this case, the acquisition function 151 determines whether or not a predetermined time has elapsed since the previous blood glucose level measurement (S7). When the acquisition function 151 determines that the predetermined time has not elapsed since the previous blood glucose level measurement (S7 “No”), the process returns to S6. Further, when the acquisition function 151 determines that a predetermined time has elapsed since the previous blood glucose level measurement (S7 “Yes”), the process returns to the process of S1.

As described above, according to the drug solution administration device 1 of the present embodiment, blood is collected from the subject P by one cannula 22, and insulin supplied from the pump 17 is injected into the subject P. The burden on the specimen P can be reduced.

For example, in the case of an apparatus provided with a cannula for collecting blood for measuring a blood glucose level and a cannula for administering insulin, the cannula is inserted into two places of the body of the subject. Continuing to attach cannulas to multiple locations on the subject's body may place a burden on the subject.

On the other hand, in the medical fluid administration device 1 of the present embodiment, the cannula 22 to be inserted into the subject P is used to collect blood from the subject P and inject insulin into the subject P by the single cannula 22. Can be one, and the burden on the subject P can be reduced.

In addition, for example, when the patient (subject) manually measures the blood glucose level and manually sets the insulin dose based on the result, when the blood glucose measurement result is erroneously read or the insulin dose is Incorrect settings may occur. In this case, the wrong amount of insulin may be administered to the subject. Particularly in type I diabetes, since the subject is often a child, it may not be easy for the subject to measure the blood glucose level and adjust the dose of insulin.

On the other hand, in the medical fluid administration device 1 of the present embodiment, the pump 17 is controlled based on the blood glucose level measurement result by the blood glucose level sensor 21 to adjust the amount of insulin supplied to the cannula 22. It is possible to avoid that the specimen administers an incorrect amount of insulin by manually setting the dose. Therefore, according to the drug solution administration device 1 of the present embodiment, the occurrence of erroneous administration of insulin can be reduced.

Further, for example, when insulin is administered to a person other than a diabetic patient or a person with a normal blood glucose level, hypoglycemia may be caused. On the other hand, in the liquid medicine administration device 1 of the present embodiment, the amount of insulin is automatically adjusted based on the blood glucose level measurement result by the blood glucose level sensor 21, so that insulin administration is not necessary for people who do not need to administer insulin. It is possible to avoid erroneous administration of insulin.

Furthermore, according to the cannula 22 of the drug solution administration device 1 of the present embodiment, the first opening 221 for collecting blood and the second opening 222 for injecting insulin are oriented in different directions. Therefore, blood can be collected from a place different from the place where insulin is administered. Therefore, according to the drug solution administration device 1 of the present embodiment, the blood glucose level can be measured with high accuracy even when blood is collected and insulin is administered by one cannula 22.

Further, according to the cannula 22 of the drug solution administration device 1 of the present embodiment, the length from the root of the cannula 22 to the first opening 221 is different from the length from the root of the cannula 22 to the second opening 222. Therefore, by collecting blood at a position farther from the place where insulin is administered, the blood glucose level can be measured with higher accuracy.

Further, according to the drug solution administration device 1 of the present embodiment, an alert for notifying that the blood glucose measurement result by the blood glucose sensor 21 or the blood glucose measurement result is equal to or lower than the first threshold value or equal to or higher than the second threshold value is displayed. Since it is displayed on the display 12, the subject P can quickly know that the subject P has hypoglycemia or hyperglycemia.

Further, according to the drug solution administration device 1 of the present embodiment, an alert for notifying that the blood glucose measurement result by the blood glucose sensor 21 or the blood glucose measurement result is equal to or lower than the first threshold value or equal to or higher than the second threshold value is displayed. Since the sound or voice is output, it is possible for the subject P or a person around the subject P to quickly recognize that the subject P is hypoglycemic or hyperglycemic. For example, when the subject P is blind, the drug solution administration device 1 outputs the measurement result of blood glucose level and the alert by voice, so that the state of blood glucose level can be easily grasped by the subject P.

Further, according to the liquid medicine administration device 1 of the present embodiment, the blood glucose level measurement result by the blood glucose level sensor 21, the insulin dose (injection amount), or the blood glucose measurement result is equal to or less than the first threshold value or the second threshold value. Since the alert notifying the above is transmitted to the external device, the state of the blood glucose level of the subject P can be recorded and managed by the electronic medical chart device 5 and the like. This allows the doctor to make a diagnosis after observing the control status of the blood glucose level when examining the subject P. Further, according to the drug solution administration device 1 of the present embodiment, by transmitting the alert to the parent smartphone 4 of the subject P, when the subject P is a child, the parent or the like of the subject P is the subject P. The condition can be grasped quickly. For example, when the smartphone 4 receives an alert notifying that the blood glucose measurement result is less than or equal to the first threshold, the parent or the like of the subject P takes prompt action such as allowing the subject P to take glucose or the like. can do.

Although the processing circuit 15 is an example of the control unit in the present embodiment, the pump control function 153 may be an example of the control unit. Further, in the present embodiment, the interface circuit 14 is an example of the communication unit, but the transmission function 155 may be an example of the communication unit, or the interface circuit 14 and the transmission function 155 may be combined as an example of the communication unit. good.

Further, in the present embodiment, the transmission function 155 transmits to the external device each time the acquisition function 151 acquires the blood glucose measurement result or each time the determination function 152 determines the insulin dose, The transmission timing is not limited to this. For example, the transmission function 155 may be configured to periodically transmit the history of blood glucose measurement results and the history of insulin dose stored in the storage circuit 16 to an external device.

Further, the content of the alert displayed or output by the display 12 or the audio output device 13 of the present embodiment is not limited to the above example. For example, the display 12 or the audio output device 13 includes sugars such as "please eat cookies" and "drink juice" instead of directly displaying or outputting "Please ingest 5g of glucose". You may display or output the message instructing to ingest food and drink. Further, the drug solution administration device 1 may further include a vibration function for vibrating the main body unit 10, and the output function 154 determines the main body according to the content of the alert to be output when the determination function 152 determines to output the alert. The part 10 may be vibrated.

Further, the pump 17 of the main body portion 10 of the drug solution administration device 1 may be configured to supply the drug solution containing sugar to the cannula 22. In the case of adopting the configuration, when the determination function 152 determines that the blood glucose measurement result is equal to or lower than the first threshold value, the pump control function 153 supplies the drug solution containing the sugar to the cannula 22 to detect the subject. A drug solution containing sugar is administered to P.

Further, in the present embodiment, the cable 30 includes the tube and the transmission line, but the tube and the transmission line may be provided as separate cables. Further, the blood glucose sensor 21 of the present embodiment may have a short-range wireless communication function such as WiFi (registered trademark), Bluetooth (registered trademark), or RFID. In this case, the blood sugar level sensor 21 transmits the measured blood sugar level to the main body 10 by short-range wireless communication.

Further, in the present embodiment, the cannula 22 is in the state of being placed in the subject P, but the cannula 22 may be movable. For example, the mounting part 20 includes a movable part that inserts and withdraws the cannula 22, and the movable part is inserted into the subject P when collecting blood or administering insulin under the control of the processing circuit 15. Alternatively, it may be extracted from the subject P after the end of administration.

Further, in the present embodiment, the blood glucose level sensor 21 measures the glucose level in the blood, but the blood glucose level sensor 21 may measure the glucose level in the subcutaneous interstitial fluid of the subject P. .. In this case, subcutaneous interstitial fluid is an example of body fluid. Further, the drug solution administration device 1 may include a sensor that measures a target substance other than blood glucose. For example, the drug solution administration device 1 may include a sensor that measures HbA1c (hemoglobin A1c) from the blood of the subject P. Further, in the present embodiment, insulin is an example of the drug solution, but the drug solution administration device 1 may be configured to administer a drug solution such as a therapeutic drug for diabetes other than insulin to the subject P.

(Second embodiment)
In the second embodiment, in addition to the first embodiment, the drug solution administration device 1 executes the authentication of the subject P before administering the insulin.

FIG. 10 is a block diagram showing an example of the configuration of the drug solution administration device 1 according to the present embodiment. Like the first embodiment, the mounting unit 20 and the main body unit 10 are provided.

The mounting unit 20 of the present embodiment includes a blood glucose level sensor 21, a cannula 22, a processing circuit 23, and a storage circuit 24. The blood glucose level sensor 21 and the cannula 22 have the same functions as in the first embodiment.

The storage circuit 24 stores the authentication information of the subject P in advance. In the present embodiment, the authentication information of the subject P is genome information of the subject P. The storage circuit 24 is realized by, for example, a RAM, a semiconductor memory device such as a flash memory, a hard disk, an optical disk, or the like.

The processing circuit 23 has an authentication function 231. The authentication function 231 analyzes the genome of the blood collected by the cannula 22, and authenticates the subject P when the analyzed result matches the genome information of the subject P stored in the memory circuit 24. The processing circuit 23 sends the authentication result of the subject P to the main body unit 10. The authentication function 231 is an example of an authentication unit. The authentication function 231 transmits the authentication result to the main body unit 10 by the transmission path included in the cable 30 or the wireless communication function.

The authentication function 231 that is a component of the processing circuit 23 is stored in the storage circuit 24 in the form of a program that can be executed by a computer. The processing circuit 23 reads out each program from the storage circuit 16 and executes each read program to realize a function corresponding to each program. In other words, the processing circuit 23 in the state where each program is read out has the authentication function 231 shown in the processing circuit 23 of FIG. In FIG. 10, the authentication function 231 is realized by the single processing circuit 23, but the processing circuit 23 is configured by combining a plurality of independent processors, and each processor executes each program. The authentication function 231 may be realized by executing it.

The main body 10 includes an input device 11, a display 12, a voice output device 13, an interface circuit 14, a processing circuit 15, a storage circuit 16, and a pump 17, as in the first embodiment. The input device 11, the display 12, the audio output device 13, the interface circuit 14, the storage circuit 16, and the pump 17 have the same functions as in the first embodiment.

The processing circuit 15 of this embodiment includes an acquisition function 1151, a determination function 152, a pump control function 153, an output function 154, and a transmission function 155. The determination function 152, the pump control function 153, the output function 154, and the transmission function 155 have the same functions as in the first embodiment.

The acquisition function 1151 of the present embodiment has the same function as that of the first embodiment, and acquires the authentication result of the subject P from the mounting unit 20. The acquisition function 1151 acquires the measurement result of the blood glucose level when the subject P is authenticated. In addition, the acquisition function 1151 does not execute the process after the acquisition of the blood glucose measurement result when the subject P is not authenticated. In this case, the determination processing by the determination function 152 and the insulin administration by the pump control function 153 are not executed.

FIG. 11 is a flowchart showing an example of the flow of the blood glucose level measurement and insulin administration processing executed by the drug solution administration device 1 according to the present embodiment.

First, the acquisition function 1151 acquires the authentication result of the subject P from the mounting unit 20 (S21). Then, the acquisition function 1151 determines whether or not the subject P has been authenticated by the authentication function 231 of the mounting unit 20 (S22). When the acquisition function 1151 determines that the subject P has been authenticated by the authentication function 231 of the mounting unit 20 (S22 “Yes”), the acquisition function 1151 proceeds to the acquisition process of the blood glucose measurement result in S1.

In this case, the processes of S1 to S7 are executed as in the first embodiment. That is, in the present embodiment, when the subject P is authenticated, the pump control function 153 controls the pump 17 to supply insulin to the cannula 22.

Further, when the acquisition function 1151 determines that the subject P is not authenticated by the authentication function 231 of the mounting unit 20 (S22 “Yes”), the process of S21 is repeated. In this case, the processes of S1 to S7 are not executed.

As described above, according to the drug solution administration device 1 of the present embodiment, when the subject P is authenticated, the pump 17 is controlled and insulin is supplied to the cannula 22, so that the subjects other than the subject P registered in advance are controlled. It is possible to avoid giving insulin to a person. Therefore, according to the drug solution administration device 1 of the present embodiment, the occurrence of erroneous administration of insulin can be further reduced.

In the present embodiment, the subject P is authenticated based on the genome analysis result of the blood of the subject P, but the authentication method is not limited to this. For example, the drug solution administration device 1 may authenticate the subject P by communicating with a wearable terminal attached to the subject P, a smartphone, or the like. Further, biometric authentication other than genome analysis may be adopted as the authentication method.

Further, instead of the processing circuit 15 of the mounting unit 20, the processing circuit 15 of the main body unit 10 may be configured to have the authentication function 231. When the configuration is adopted, the storage circuit 16 of the main body unit 10 stores the authentication information of the subject P in advance.

(Modification 1)
The form of the cannula 22 included in the drug solution administration device 1 is not limited to the form described in the first embodiment.

FIG. 12 is a diagram showing an example of the cannula 22 according to the present modification. As shown in FIG. 12, the cannula 22 may include a plurality of second openings 222a and 222b. In FIG. 12, the number of the second openings 222 is not limited to one or two, and the cannula 22 may include a larger number of the second openings 222.

(Modification 2)
Further, FIG. 13 is a diagram showing an example of the cannula 22 according to the present modification. The cannula 22 may have a shape with a narrowed tip as shown in FIG. Also, the first opening 221 may be located in the center of the narrowed tip of the cannula 22.

In each of the above-described embodiments, the cannula 22 collects the blood of the subject P from the first opening 221 and injects insulin into the subject P from the second opening 222. The use of the opening 221 and the second opening 222 of is not limited to this. For example, the cannula 22 may inject insulin into the subject P through the first opening 221 and collect the subcutaneous interstitial fluid of the subject P through the second opening 222.

According to at least one embodiment described above, the burden on the subject P can be reduced.

Although some embodiments of the present invention have been described, these embodiments are presented as examples and are not intended to limit the scope of the invention. These embodiments can be implemented in various other forms, and various omissions, replacements, and changes can be made without departing from the spirit of the invention. These embodiments and modifications thereof are included in the invention described in the claims and equivalents thereof as well as included in the scope and the gist of the invention.

DESCRIPTION OF SYMBOLS 1 Chemical liquid administration device 10 Main body part 11 Input device 12 Display 13 Voice output device 14 Interface circuit 15 Processing circuit 16 Storage circuit 17 Pump 20 Mounting part 21 Blood glucose sensor 22 Cannula 23 Processing circuit 24 Storage circuit 30 Cable 151,1151 Acquisition function 152 Judgment function 153 Pump control function 154 Output function 155 Transmission function 161 Insulin administration reference database 221 First opening 222, 222a, 222b Second opening 223 First hollow 224 Second hollow 231 Authentication function P Covered Specimen

Claims (8)

One cannula for collecting body fluid from a subject and injecting a drug solution supplied from a pump into the subject,
A sensor for measuring the target substance in the collected body fluid,
A control unit that controls the pump based on the measurement result of the target substance by the sensor and adjusts the amount of the chemical liquid supplied to the cannula;
A liquid medicine administration device comprising: The cannula is
A first opening for collecting the body fluid from the subject;
A second opening for injecting the drug solution into the subject,
The first opening and the second opening are provided in different directions,
The drug solution administration device according to claim 1. The length from the root of the cannula to the first opening and the length from the root of the cannula to the second opening are different lengths,
The drug solution administration device according to claim 2. The measurement part of the said target substance by the said sensor, or the display part which displays the alert which notifies that the measurement result of the said target substance by the said sensor is below a 1st threshold value or above a 2nd threshold value is further provided. ,
The drug solution administration device according to any one of claims 1 to 3. Voice output that outputs an alert by sound or voice notifying that the measurement result of the target substance by the sensor or the measurement result of the target substance by the sensor is less than or equal to a first threshold value or greater than or equal to a second threshold value. Further comprises,
The drug solution administration device according to any one of claims 1 to 4. An alert notifying that the measurement result of the target substance by the sensor, the injection amount of the chemical liquid, or the measurement result of the target substance by the sensor is equal to or lower than a first threshold value or equal to or higher than a second threshold value, Further comprising a communication unit for transmitting to the device,
The drug solution administration device according to any one of claims 1 to 5. The control unit controls the pump to supply the drug solution to the cannula when the subject is authenticated.
The drug solution administration device according to any one of claims 1 to 6. The body fluid is blood,
The target substance is glucose,
The sensor measures the concentration of glucose in the blood collected,
The drug solution administration device according to any one of claims 1 to 7.

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