JP2020103834A - Blood purification device - Google Patents

Abstract

To provide a blood purification device in which failure of a liquid temperature adjustment for a supply liquid is difficult to occur.SOLUTION: A blood purification device comprises: a blood circuit 2 for extracorporeally circulating blood of a patient; a liquid supply circuit 4 for supplying a supply liquid to the blood circuit 2 or a blood purifier 3 provided on the blood circuit 2; and warming tools 65, 75 which are provided on the liquid supply circuit 4 for warming the supply liquid. The warming tools 65, 75 comprise: a heater 654 which is provided on a holding plane 651a being configured to hold a warming circuit 66 being a part of the liquid supply circuit 4 and for holding the warming circuit 66; a heater temperature detection part for detecting a temperature of the heater 654; and a liquid temperature detection temperature sensor 656 being provided at a position which is separated from the heater 654 on the holding plane 651a and contacts the warming circuit 66 on a downstream side of a liquid feeding direction of a warmed part warmed by the heater 654, and capable of detecting a temperature of the supply liquid flowing in the warming circuit 66.SELECTED DRAWING: Figure 4

Description

The present invention relates to a blood purification device.

In the blood purification device, when the temperature of the dialysate or the replenisher is low, the temperature of the blood returned to the patient is lowered, and the patient feels cold. Therefore, conventionally, a blood purification apparatus having a warmer for heating a supply liquid such as a dialysate or a replenisher has been used (see, for example, Patent Document 1).

JP, 2017-080266, A

The blood purification device has a temperature sensor (for example, a clip-type temperature sensor) for liquid temperature detection separately from the warmer, and controls the warmer so that the temperature of the supply liquid reaches a set temperature. It has been known. However, in such a blood purification apparatus, there are cases where the temperature sensor for detecting the liquid temperature is forgotten to be attached, or normal attachment is not performed. In this case, the liquid temperature of the supply liquid such as dialysate or replenisher may not be controlled correctly, and improvement is desired.

Therefore, it is an object of the present invention to provide a blood purification device in which the problem of adjusting the temperature of the supply liquid is unlikely to occur.

In order to solve the above problems, the invention according to claim 1 supplies a supply liquid to a blood circuit for extracorporeally circulating a patient's blood, the blood circuit, or a blood purifier provided in the blood circuit. A liquid supply circuit and a warmer provided in the liquid supply circuit for heating the supply liquid are provided, and the warmer sandwiches a heating circuit which is a part of the liquid supply circuit. And a heater provided on a holding surface that holds the heating circuit, a heater temperature detection unit that can detect the temperature of the heater, and a position of the holding surface that is separated from the heater. In addition, when the heating circuit is held, the heating circuit is provided at a position abutting the heating circuit on the downstream side in the liquid feeding direction with respect to the portion heated by the heater. There is provided a blood purification device having a liquid temperature detecting temperature sensor capable of detecting the temperature of a supply liquid flowing through a power supply circuit.

According to a second aspect of the present invention, based on the temperature of the heater detected by the heater temperature detection unit and the temperature of the supply liquid detected by the temperature sensor for liquid temperature detection, the heating of the heating circuit is performed. The blood purification apparatus according to claim 1, further comprising a warming device mounting detection unit that detects whether or not the device is mounted on the device.

In the invention according to claim 3, in the warmer mounting detection unit, after the warmer starts heating, the temperature detected by the heater temperature detection unit reaches a predetermined upper limit temperature, and When the rise in the temperature detected by the temperature sensor for liquid temperature detection from the start of heating of the warmer is less than a predetermined abnormality determination threshold value, the warming circuit is not mounted on the warmer. The blood purification apparatus according to claim 2, wherein the determination is performed.

According to a fourth aspect of the present invention, the heater control unit controls the temperature of the heater so that the temperature of the supply liquid detected by the temperature sensor for liquid temperature detection becomes a preset temperature, The control unit is the blood purification apparatus according to any one of claims 1 to 3, wherein an upper limit value of the heater temperature can be set according to a supply liquid used.

The invention according to claim 5 is such that the heater control unit is configured to be able to change the upper limit temperature depending on whether or not the supply liquid to be used contains a protein component. It is a device.

In the invention according to claim 6, the upper limit temperature is less than 46 degrees when the feed solution used contains a protein component, and the upper limit temperature is 46 degrees or more when the feed solution used does not contain a protein component. The blood purification apparatus according to claim 5, wherein

The invention according to claim 7 is the blood purification apparatus according to any one of claims 1 to 6, wherein the heater temperature detection unit is a temperature sensor for a heater provided in a heating region of the heater. is there.

According to the invention of claim 1, it is possible to provide the blood purification device in which the trouble of adjusting the liquid temperature of the supply liquid is unlikely to occur.

According to the invention of claim 2, it is possible to detect whether or not the warming circuit is attached to the warmer.

According to the invention of claim 3, it is possible to accurately detect whether or not the heating circuit is attached to the warmer.

According to the inventions of claims 4 to 6, it is possible to suppress the coagulation of the protein component when the supply liquid containing the protein component is used.

According to the invention of claim 7, the heater temperature detecting portion can be realized easily and at low cost.

1 is a schematic configuration diagram of a blood purification device according to an embodiment of the present invention. It is a figure which shows the external appearance of the blood purification apparatus of FIG. It is a top view of a heating circuit. (A) is a perspective view of a dialysate warmer, (b) is the A section enlarged view. (A) is a graph which shows the change of the detected value of the temperature sensor for heaters and the temperature sensor for liquid temperature detection in the state where a heating circuit is not mounted, (b) is a heating circuit mounted It is a graph figure which shows the change of the detected value of the temperature sensor for heaters in the state which carried out, and the temperature sensor for liquid temperature detection.

[Embodiment]
Embodiments of the present invention will be described below with reference to the accompanying drawings.

FIG. 1 is a schematic configuration diagram of the blood purification device according to the present embodiment. As shown in FIG. 1, the blood purification apparatus 1 includes a blood circuit 2 for extracorporeally circulating a patient's blood, a blood purifier 3 provided in the blood circuit 2 for purifying blood, the blood purifier 3, or the blood circuit 2. A liquid supply circuit 4 for supplying a supply liquid to the blood and a drainage circuit 5 for discharging drainage from the blood purifier 3. The blood circuit 2, the liquid supply circuit 4 (the dialysate circuit 6 and the replenisher circuit 7 which will be described later), and the drainage circuit 5 are configured by using flexible tubes.

An arterial puncture needle 21 is provided at one end of the blood circuit 2, and a vein puncture needle 22 is provided at the other end. In the blood circuit 2, the first air bubble detection device 23, the blood pump 24, the blood purifier 3, the gas-liquid separator 25, and the second air bubble detection device from the artery side puncture needle 21 side to the vein side puncture needle 22 side. 26 are sequentially provided. The first bubble detection device 23 and the second bubble detection device 26 have a bubble detection sensor for detecting bubbles and a mechanism for clamping (sandwiching and closing) the blood circuit 2 when detecting bubbles. ..

The blood pump 24 is a peristaltic pump that squeezes a tube to flow blood to the blood purifier 3 side. The blood purifier 3 is also called a dialyzer, and purifies the blood by bringing the blood and the dialysate into contact with each other via a blood purification membrane (not shown). The gas-liquid separator 25 is configured to remove bubbles and pass only the liquid to the venous puncture needle 22 side.

In the present embodiment, in order to enable various treatments with the blood purification device 1, as the liquid supply circuit 4, both a dialysate circuit 6 for supplying a dialysate and a replenisher circuit 7 for supplying a replenisher are provided. Have However, the blood purification device 1 may have only one of the dialysate circuit 6 and the replenisher circuit 7.

A dialysate storage bag 61 for storing dialysate is connected to one end of the dialysate circuit 6. The other end of the dialysate circuit 6 is connected to the dialysate inlet of the blood purifier 3. In the dialysate circuit 6, the dialysate transfer pump 62, the dialysate subdivision chamber 63 for temporarily storing the dialysate, the dialysate pump 64, the dialysate warming from the dialysate storage bag 61 side to the blood purifier 3 side. The device 65 is sequentially provided.

The dialysate transfer pump 62 and the dialysate pump 64 are peristaltic pumps that squeeze the tubes to flow the dialysate. The dialysate transfer pump 62 is used to transfer the dialysate in the dialysate storage bag 61 to the dialysate subdivision chamber 63. The dialysate pump 64 is used to flow the dialysate in the dialysate subdivision chamber 63 to the blood purifier 3 side. By having the dialysate subdivision chamber 63, the dialysate storage bag 61 can be replaced without interrupting the treatment. The dialysate warmer 65 is for warming the dialysate to an appropriate temperature so as not to lower the temperature of blood returned to the patient, and is one aspect of the warmer of the present invention. Details of the dialysate warmer 65 will be described later.

A replenisher solution storage bag 71 for replenisher solution is connected to one end of the replenisher solution circuit 7. In the replenishment liquid circuit 7 downstream of the replenishment liquid storage bag 71, a replenishment liquid transfer pump 72, a replenishment liquid subdivision chamber 73 for temporarily storing the replenishment liquid, a replenishment liquid pump 74, a replenishment liquid warmer 75, and A gas-liquid separator 76 is sequentially provided.

Further, the replenishment liquid circuit 7 is branched downstream of the gas-liquid separator for replenishment liquid 76, and one end of the branching replenishment liquid circuit 7 that is the front replenishment liquid circuit 7 a is connected to the blood purifier 3 and the blood pump 24. It is connected to the blood circuit 2 in between. The front replacement fluid circuit 7a is provided with a front replacement fluid pump 77. The end of the post-replenishment fluid circuit 7b, which is the other branched replenishment fluid circuit 7, is connected to the gas-liquid separator 25 of the blood circuit 2.

The replenishing liquid transfer pump 72, the replenishing liquid pump 74, and the pre-replacement liquid pump 77 are peristaltic pumps that squeeze the tube to flow the dialysate. The replenishment liquid transfer pump 72 is used to transfer the replenishment liquid in the replenishment liquid storage bag 71 to the replenishment liquid subdivision chamber 73. The replenisher pump 74 is used for flowing the replenisher in the replenisher subdivision chamber 73 to the blood circuit 2 side. The pre-replacement fluid pump 77 is driven when performing “pre-replacement fluid” that supplies replenishment fluid to the blood circuit 2 on the upstream side of the blood purifier 3. When the front replacement fluid pump 77 is not driven, the replacement fluid sent by the replacement fluid pump 74 passes through the rear replacement fluid circuit 7b, and the blood circuit 2 on the downstream side of the blood purifier 3 (here, the gas-liquid separator 25). "Post-replacement fluid" is performed to supply the replenisher fluid to the.

By having the replenisher subdividing chamber 73, it becomes possible to replace the replenisher containing bag 71 without interrupting the treatment. The replenisher solution warmer 75 is for heating the replenisher solution to an appropriate temperature so as not to lower the temperature of the blood returned to the patient, and is one aspect of the warmer of the present invention. The replenisher gas-liquid separator 76 is for separating and removing air bubbles from the replenisher.

One end of the drainage circuit 5 is connected to the drainage outlet of the blood purifier 3. In the drainage circuit 5 downstream of the blood purifier 3, a drainage pump 51, a drainage subdivision chamber 52 for temporarily storing drainage, and a drainage pump 53 are sequentially provided. The other end of the drainage circuit 5 serves as a drainage outlet 54 for discharging drainage to the outside of the device.

The drainage pump 51 and the drainage pump 53 are peristaltic type pumps that squeeze a tube to flow dialysate. The drainage pump 51 is used to feed the drainage to the drainage subdivision chamber 52. The drainage pump 53 is used to drain the drainage in the drainage subdivision chamber 52 to the drainage outlet 54 side.

The blood purification apparatus 1 also includes a water removal amount detection unit 10 that detects the water removal amount based on the supply amount of the supply liquid and the discharge amount of the drainage liquid. The water removal amount detection unit 10 includes the above-described subdivision chambers 63, 73, 52, a load meter 8 as a weight detection mechanism capable of detecting the total weight of the subdivision chambers 63, 73, 52, and a water removal amount calculation. And a section 91.

The load meter 8 is configured to detect the total weight of the dialysate subdivision chamber 63, the replenisher subdivision chamber 73, and the drainage subdivision chamber 52. The detection value of the load meter 8 is output to the control device 9.

The water removal amount calculation unit 91 detects the water removal amount by detecting the time change of the detection value of the load meter 8. The water removal amount calculation unit 91 is mounted on the control device 9, and is realized by appropriately combining a calculation element such as a CPU, a memory, a storage device, software, an interface, and the like.

Further, the blood purification device 1 uses one of the liquid supply pump (dialysate pump 64 and replenisher pump 74) and the drainage pump 51 so that the water removal amount detected by the water removal amount detection unit 10 matches the target water removal amount. Alternatively, a water removal amount control unit 92 that corrects both pump speeds (pump flow rates) is provided. The water removal amount control unit 92 is mounted on the control device 9 and is realized by appropriately combining an arithmetic element such as a CPU, a memory, a storage device, software, and an interface.

(Heater and its control)
Here, the dialysate warmer 65 and its control will be described. Although the replenisher warmer 75 and its control are not described here, it has the same structure as the dialysate warmer 65 described below, and the same control as the dialysate warmer 65 is performed. ing.

FIG. 2 is a diagram showing an appearance of the blood purification device 1. FIG. 3 is a plan view of the heating circuit. FIG. 4A is a perspective view of the dialysate warmer 65, and FIG. 4B is an enlarged view of part A thereof. As shown in FIGS. 2 to 4, the dialysate warmer 65 is provided laterally of the blood purification device 1 so as to be openable and closable.

The dialysate warmer 65 is configured to sandwich a warming circuit 66 which is a part of the dialysate circuit 6. As shown in FIG. 3, the heating circuit 66 is also called a heating bag, and for example, the flow passage 66a is formed by stacking and welding two flexible sheets. .. The flow path 66a is formed to meander, and one end of the flow path 66a serves as a dialysate inlet 66b, and the other end serves as a dialysate outlet 66c. A tube 6a extending from the dialysate pump 64 is connected to the inflow port 66b, and a tube 6b extending to the blood purifier 3 is connected to the outflow port 66c. Since the heating circuit 66 is made of a softer material than the tubes 6a and 6b, if the dialyzer warming device 65 is forgotten to be attached and left unattended, not only the dialysate will not be heated, but for some reason. There is a risk that the dialysate may be supplied to the blood purifier 3 at a flow rate different from the intended flow rate due to damage to the blood purifier 3 due to external pressure or the dialysate pooling in the heating circuit 66. Occurs. Therefore, if the user forgets to attach the heating circuit 66 to the dialysate warmer 65, it is desired to inform the user of that fact.

The dialysate warmer 65 is rotatably provided on the fixed portion 651 via a fixed portion 651 fixed to a side portion of the blood purification apparatus 1 and a hinge portion 653 provided below the fixed portion 651. And a lid portion 652, and the heating circuit 66 is sandwiched between the fixing portion 651 and the lid portion 652. The holding surface 651a of the fixing portion 651 (the surface that holds the heating circuit 66) is for heating the heating circuit 66 and for heating the dialysate flowing in the heating circuit 66. A plate-shaped heater 654 is provided. Although the case where the heater 654 is provided in the fixed portion 651 will be described here, the heater 654 may be provided in the lid portion 652 or may be provided in both the fixed portion 651 and the lid portion 652. May be.

The heater 654 is provided so as to sandwich the flow path 66 a (meandering portion) of the heating circuit 66 when the heating circuit 66 is held. Although the heater 654 is provided on both the fixing portion 651 and the lid portion 652 here, the heater 654 may be provided on only one of them.

Further, the dialysate warmer 65 is a heater temperature sensor 655 as a heater temperature detector that can detect the temperature of the heater 654, and a liquid temperature detector that can detect the temperature of the dialysate flowing through the warming circuit 66. And a temperature sensor 656.

The heater temperature sensor 655 is provided in the heating region of the heater 654, detects the temperature of the heater 654, and is, for example, a thermistor. Here, the heater temperature sensor 655 is shown mounted on the fixed portion 651 side (the side on which the heater 654 is provided), but on the lid portion 652 side (the side on which the heater 654 is not provided). It may be installed. Further, a plurality of heater temperature sensors 655 may be included. The heater temperature detection unit is not limited to the heater temperature sensor 655, and may be configured using, for example, a current sensor that detects the current supplied to the heater 654. In this case, the temperature of the heater 654 is detected (estimated) based on the current value detected by the current sensor.

The liquid temperature detecting temperature sensor 656 is located at a position separated from the heater 654 of the holding surface 651a, and when the heating circuit 66 is held, the liquid temperature is higher than the portion heated by the heater 654. It is provided at a position in contact with the heating circuit 66 on the downstream side in the direction. That is, in the blood purification apparatus 1, when the warming circuit 66 is attached to the dialysate warmer 65, the temperature sensor 656 for detecting the fluid temperature abuts on the warming circuit 66 without any other operation, and the dialysate warms up. The temperature can be detected. Therefore, as in the case where the temperature sensor 656 for detecting the liquid temperature is provided separately from the dialysate warmer 65, a human error such as forgetting to attach the sensor or a defect at the time of mounting is unlikely to occur. The liquid temperature detecting temperature sensor 656 is, for example, a thermistor.

In order to suppress the influence of heat from the heater 654, it is desirable that the liquid temperature detecting temperature sensor 656 be provided at a position that is thermally shielded from the heater 654 as much as possible. In the present embodiment, the member that covers the periphery of the heater 654 (the member that forms the sandwiching surface 651a around the heater 654) is made of a resin member having a high heat insulation property, and is separated from the heater 654 via the member. A liquid temperature detecting temperature sensor 656 was provided at the position. The liquid temperature detecting temperature sensor 656 contacts the surface of the heating circuit 66 and detects the temperature of the contact portion. Since the heating circuit 66 is made of a thin sheet, the temperature of the surface of the heating circuit 66 becomes substantially equal to the temperature of the dialysate flowing in the heating circuit 66.

The blood purification apparatus 1 includes a heater control unit 93 that controls the temperature of the heater 654 so that the temperature of the dialysate detected by the temperature sensor for liquid temperature detection 656 becomes a preset temperature. The heater control unit 93 sets the heater target temperature based on the difference between the set temperature and the dialysate temperature, for example, so that the temperature of the heater 654 detected by the heater temperature sensor 655 becomes the heater target temperature. Temperature control of the heater 654 (control of supply current, etc.) is performed. The heater control unit 93 is mounted on the control device 9 and is realized by appropriately combining an arithmetic element such as a CPU, a memory, a storage device, software, and an interface.

The heater control unit 93 may be configured to be able to set an upper limit value (referred to as an upper limit temperature) of the temperature of the heater 654 according to the supply liquid (dialysis liquid or replenishing liquid) used. Furthermore, the heater control unit 93 may be configured to be able to change the upper limit temperature depending on whether or not the supply liquid used contains a protein component.

Specifically, in a treatment mode called PE (plasma exchange therapy), PA (plasma adsorption method), or DFPP (double filtration plasma exchange), a fresh frozen plasma containing a protein component such as alpmin is supplied. Used as. A protein component such as albumin has the property of whitening and coagulating when heated with high heat of 46° C. or higher. The temperature at which the protein component coagulates depends on the protein component and is about 41°C to 46°C. Therefore, when the feed liquid used contains a protein component, the upper limit temperature is preferably lower than 46°C, more preferably 40°C or lower. On the other hand, in continuous hemodialysis (CHD), CHDF (continuous hemodiafiltration), or CHF (continuous hemofiltration), since a dialysate containing no protein component is used, the upper limit temperature may be 46°C or higher. it can.

In addition, for example, when heating the low temperature supply liquid of less than 20° C., it may be necessary to heat the temperature of the heater 654 to 46° C. or higher. However, if the heating amount is too large, there is a risk that the user will get burned when touching the surfaces of the warmers 65 and 75 at the time of cleaning up, so that the temperature of the heater 654 does not have a risk of burns. It is desired to control the temperature, for example below 51°C. The heater control unit 93 is configured to stop heating by the heater 654 when the temperature detected by the heater temperature sensor 655 is 51° C. or higher, for example.

The temperature of the supply liquid at the time when the blood joins the blood circuit 2 that circulates extracorporeally needs to be controlled to be less than 46°C. This is because when a supply liquid of 46° C. or higher comes into contact with blood, a phenomenon called hemolysis in which red blood cells are destroyed occurs. Therefore, it is necessary to monitor the detection value of the liquid temperature detecting temperature sensor 656 so that the temperature of the supply liquid becomes less than 46° C. at the time of joining the blood circuit 2. The heater control unit 93 is configured to stop heating by the heater 654, for example, when the temperature detected by the temperature sensor 656 for liquid temperature detection is 46° C. or higher.

As described above, the heater temperature sensor 655 has a role of monitoring overheating of the heater 654, and the liquid temperature detecting temperature sensor 656 has a role of monitoring overheating of the supply liquid. It is desirable that the heater temperature sensor 655 and the liquid temperature detection temperature sensor 656 are independently provided.

Further, the blood purification apparatus 1 uses the warmer of the heating circuit 66 based on the temperature of the heater 654 detected by the heater temperature sensor 655 and the temperature of the dialysate detected by the liquid temperature detection temperature sensor 656. A warming device mounting detection unit 94 for detecting the presence/absence of mounting on the heating device 65, 75 is provided. The warmer attachment detection unit 94 is mounted on the control device 9 and is realized by appropriately combining an arithmetic element such as a CPU, a memory, a storage device, software, an interface, and the like.

When the dialysate pump 64 is driven and the temperature of the dialysate does not rise even if the temperature of the heater 654 is raised, the warmer attachment detection unit 94 detects the warmer 65 of the warming circuit 66. , 75 is not attached (that is, the heating circuit 66 is forgotten to be attached).

FIG. 5A is a graph showing changes in the detected values of the heater temperature sensor 655 and the liquid temperature detecting temperature sensor 656 when the heating circuit 66 is not attached. Here, the flow rate of the dialysate was 1000 mL/h. As shown in FIG. 5A, in a state where the heating circuit 66 is not attached, the detection value of the liquid temperature detection temperature sensor 656 does not increase even if the heater temperature is increased, and the liquid temperature detection temperature sensor 656 is not used. The detected value of does not reach the set temperature.

FIG. 5B is a graph showing changes in the detected values of the heater temperature sensor 655 and the liquid temperature detection temperature sensor 656 in the state where the heating circuit 66 is mounted. The flow rate of the dialysate was 1000 mL/h as in the case of FIG. As shown in FIG. 5B, in the state where the heating circuit 66 is mounted, the detection value (liquid temperature) detected by the liquid temperature detection temperature sensor 656 rises as the heater temperature rises, and the liquid temperature rises. The detection value (liquid temperature) of the detection temperature sensor 656 has reached the set temperature. In this way, the detection value of the liquid temperature detecting temperature sensor 656 greatly changes between the state in which the heating circuit 66 is attached and the state in which it is not attached. The warmer mounting detection unit 94 uses the change in the detection value of the liquid temperature detecting temperature sensor 656 depending on whether or not the warming circuit 66 is mounted, and thus the warmer 65 of the warming circuit 66, The presence/absence of attachment to 75 is detected.

More specifically, the warmer mounting detection unit 94 determines that the temperature detected by the heater temperature sensor 655 has reached a predetermined upper limit temperature after the warmers 65 and 75 start heating, and When the rise in the temperature detected by the temperature sensor 656 for detecting the liquid temperature from the start of heating the warmers 65, 75 is less than a predetermined abnormality determination threshold value, the warming circuit 66 is attached to the warmers 65, 75. It is determined that it has not been done. In other words, the warmer mounting detection unit 94 detects that the temperature of the heater 654 has risen sufficiently, but the detected temperature of the liquid temperature detecting temperature sensor 656 does not rise sufficiently, the warming circuit 66. Is not attached to the warmers 65 and 75. The specific algorithm for determining that the heating circuit 66 is not attached to the warmers 65 and 75 is not limited to this. For example, the temperature of the supply liquid before heating, the heater temperature sensor 655, and the like. The temperature of the supply liquid at the position where the temperature sensor for liquid temperature detection 656 is provided is estimated from the detected temperature and the flow rate of the supply liquid, and the estimated temperature and the temperature actually detected by the temperature sensor for liquid temperature detection 656 are estimated. When the deviation becomes larger than the predetermined threshold value, it may be determined that the heating circuit 66 is not attached to the warmers 65 and 75.

Furthermore, the blood purification apparatus 1 includes an alarm unit 11 that issues an alarm when the warmer mounting detection unit 94 detects that the heating circuit 66 has not been mounted. The alarm unit 11 has an alarm device 111 that displays a warning message on a display device 111a (see FIG. 2) such as light, sound, vibration, or monitor, and an alarm control unit 112 that controls the alarm device 111. There is. The alarm device 111 includes, for example, a buzzer that emits a warning sound by sound and a display device that displays a warning message. The alarm control unit 112 causes, for example, a buzzer to sound and a warning message to be displayed on the display. The alarm control unit 112 is mounted on the control device 9 and is realized by appropriately combining an arithmetic element such as a CPU, a memory, a storage device, software, an interface and the like.

(Operation and Effect of Embodiment)
As described above, in the blood purification device 1 according to the present embodiment, the warmers 65 and 75 for heating the supply liquid sandwich the heating circuit 66 that is a part of the liquid supply circuit 4. And a heater 654 provided on the holding surface 651a that holds the heating circuit 66, a heater temperature sensor 655 as a heater temperature detection unit that can detect the temperature of the heater 654, and When the heating circuit 66 is held at a position separated from the heater 654 on the surface 651a, the heating circuit 66 is provided downstream of the portion heated by the heater 654 in the liquid feeding direction. And a liquid temperature detecting temperature sensor 656 which is provided at a contact position and is capable of detecting the temperature of the supply liquid flowing through the heating circuit 66.

By mounting both the heater temperature detection unit (heater temperature sensor 655) and the liquid temperature detection temperature sensor 656 in the warmers 65 and 75, it is possible to prevent forgetting to attach the sensor or troubles during installation. It is possible to realize the blood purification device 1 in which the problem of adjusting the liquid temperature of the supply liquid is unlikely to occur. Further, by using both sensors 655 and 656, it becomes possible to detect the forgetting to attach the heating circuit 66 to the warmers 65 and 75. When the liquid temperature detecting temperature sensor 656 is provided separately from the warmers 65 and 75, the difference between the heater temperature and the liquid temperature may be due to forgetting to attach the heating circuit 66 or the liquid temperature detecting unit. It is impossible to determine whether the temperature sensor 656 is forgotten to be attached or due to an attachment defect. Further, when the liquid temperature detecting temperature sensor 656 is provided separately from the warmers 65, 75, the influence of the outside air temperature between the warmers 65, 75 and the mounting position of the liquid temperature detecting temperature sensor 656 is affected. However, in the present embodiment, since the temperature sensors 656 for detecting the liquid temperature are provided in the warmers 65 and 75, the temperature sensor 656 for detecting the liquid temperature is less likely to be affected by the outside air temperature. The liquid temperature can be adjusted (heater control) with higher accuracy according to the supplied liquid. Further, by determining the presence or absence of the temperature sensor 656 for detecting the liquid temperature and the heater temperature detecting portion originally necessary for the treatment, it is not necessary to separately provide a sensor or the like, and it is determined whether or not the heating circuits 65 and 75 are attached. The function to perform can be realized at low cost.

(Summary of Embodiments)
Next, the technical idea grasped from the embodiment described above will be described with reference to the reference numerals and the like in the embodiment. However, the reference numerals and the like in the following description are not intended to limit the constituent elements in the claims to the members and the like specifically shown in the embodiments.

[1] A blood circuit (2) for extracorporeally circulating a patient's blood, and a liquid supply circuit for supplying a supply liquid to the blood circuit (2) or a blood purifier (3) provided in the blood circuit (2). (4) and a warmer (65, 75) provided in the liquid supply circuit (4) for heating the supply liquid, wherein the warmer (65, 75) is the liquid supply circuit. The heater (654) is configured to hold the heating circuit (66) which is a part of (4), and is provided on the holding surface (651a) that holds the heating circuit (66). ), a heater temperature detection unit capable of detecting the temperature of the heater (654), and a position separated from the heater (654) of the sandwiching surface (651a), and the heating circuit (66). ) Is held, the heating circuit (66) is provided at a position where the heating circuit (66) comes into contact with the heating circuit (66) downstream of the portion heated by the heater (654) in the liquid feeding direction. Blood temperature purifying device (1) having a liquid temperature detecting temperature sensor (656) capable of detecting the temperature of the supply liquid flowing through the liquid purifying device (1).

[2] Based on the temperature of the heater (654) detected by the heater temperature detection unit and the temperature of the supply liquid detected by the liquid temperature detection temperature sensor (656), the heating circuit (66) The blood purification device (1) according to [1], further comprising a warmer mounting detection unit (94) for detecting whether or not the warming device (65, 75) is mounted.

[3] The warmer mounting detection unit (94), after the warmer (65, 75) starts heating, the temperature detected by the heater temperature detection unit reaches a predetermined upper limit temperature, When the rise in the temperature detected by the liquid temperature detecting temperature sensor (656) from the start of heating of the warmer (65, 75) is less than a predetermined abnormality determination threshold value, the warming circuit. The blood purification device (1) according to [2], which determines that (66) is not attached to the warmer (65, 75).

[4] A heater control unit (93) for controlling the temperature of the heater (654) so that the temperature of the supply liquid detected by the liquid temperature detection temperature sensor (656) becomes a preset temperature. The blood according to any one of [1] to [3], wherein the heater control section (93) is configured to be able to set an upper limit value of the heater temperature according to a supply liquid to be used. Purification device (1).

[5] The blood purification device according to [4], wherein the heater control unit (93) is configured to be able to change the upper limit temperature according to whether or not the supply liquid to be used contains a protein component. 1).

[6] When the feed solution used contains a protein component, the upper limit temperature is lower than 46 degrees, and when the feed solution used does not contain a protein component, the upper limit temperature is set to 46 degrees or higher, [5] Blood purification apparatus (1) according to 1.

[7] The blood according to any one of [1] to [6], wherein the heater temperature detection unit is a heater temperature sensor (655) provided in a heating region of the heater (654). Purification device (1).

Although the embodiments of the present invention have been described above, the embodiments described above do not limit the invention according to the claims. Further, it should be noted that not all combinations of the features described in the embodiments are essential to the means for solving the problems of the invention. The present invention can be appropriately modified and implemented without departing from the spirit of the present invention.

DESCRIPTION OF SYMBOLS 1... Blood purification device 2... Blood circuit 3... Blood purification device 4... Liquid supply circuit 5... Drainage circuit 6... Dialysate circuit 65... Dialysate warmer (warmer)
654... Heater 655... Heater temperature sensor 656... Liquid temperature detecting temperature sensor 66... Heating circuit 7... Replenishing liquid circuit 75... Replenishing liquid warmer (warmer)
9... Control device 93... Heater control unit 94... Warmer attachment detection unit

Claims (7)

A blood circuit for circulating the patient's blood extracorporeally,
A liquid supply circuit for supplying a supply liquid to the blood circuit, or a blood purifier provided in the blood circuit,
A warmer provided in the liquid supply circuit for heating the supply liquid;
The warmer is
It is configured to sandwich a heating circuit which is a part of the liquid supply circuit,
A heater provided on a holding surface for holding the heating circuit,
A heater temperature detection unit capable of detecting the temperature of the heater;
The heating circuit at a position separated from the heater on the sandwiching surface, and on the downstream side in the liquid feeding direction of the portion heated by the heater when the heating circuit is sandwiched. A temperature sensor for liquid temperature detection, which is provided at a position abutting on the temperature sensor and is capable of detecting the temperature of the supply liquid flowing through the heating circuit.
Blood purification device. Whether or not the heating circuit is attached to the warmer is detected based on the temperature of the heater detected by the heater temperature detection unit and the temperature of the supply liquid detected by the temperature sensor for liquid temperature detection. Equipped with a warmer attachment detection unit
The blood purification apparatus according to claim 1. The warming device mounting detection unit, when the temperature detected by the heater temperature detection unit reaches a predetermined upper limit temperature after the heating unit starts heating, and when the heating of the heating unit is started. When the increase in the temperature detected by the liquid temperature detecting temperature sensor from is less than a predetermined abnormality determination threshold value, it is determined that the heating circuit is not mounted on the warmer,
The blood purification apparatus according to claim 2. The temperature of the supply liquid detected by the temperature sensor for detecting the liquid temperature is provided with a heater control unit that controls the temperature of the heater so as to be a preset temperature.
The heater control unit is configured to be able to set an upper limit value of the heater temperature according to the supply liquid used.
The blood purification apparatus according to any one of claims 1 to 3. The heater control unit is configured to be able to change the upper limit temperature according to whether or not the supply liquid used contains a protein component.
The blood purification apparatus according to claim 4. When the feed solution used contains a protein component, the upper limit temperature is less than 46 degrees, when the feed solution used does not contain a protein component, the upper limit temperature is 46 degrees or more,
The blood purification apparatus according to claim 5. The heater temperature detection unit is a heater temperature sensor provided in a heating region of the heater,
The blood purification apparatus according to any one of claims 1 to 6.

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