JP2020099644A - Cylindrical container with filter for housing beads for fluid processing - Google Patents
Cylindrical container with filter for housing beads for fluid processing Download PDFInfo
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- JP2020099644A JP2020099644A JP2018241841A JP2018241841A JP2020099644A JP 2020099644 A JP2020099644 A JP 2020099644A JP 2018241841 A JP2018241841 A JP 2018241841A JP 2018241841 A JP2018241841 A JP 2018241841A JP 2020099644 A JP2020099644 A JP 2020099644A
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- 239000011324 bead Substances 0.000 title claims abstract description 47
- 239000012530 fluid Substances 0.000 title claims description 36
- 230000002093 peripheral effect Effects 0.000 claims abstract description 64
- 229920005992 thermoplastic resin Polymers 0.000 claims abstract description 31
- 210000004369 blood Anatomy 0.000 claims abstract description 19
- 239000008280 blood Substances 0.000 claims abstract description 19
- 238000002844 melting Methods 0.000 claims abstract description 18
- 230000008018 melting Effects 0.000 claims abstract description 18
- 238000000746 purification Methods 0.000 claims abstract description 16
- 238000003466 welding Methods 0.000 claims description 40
- 238000004519 manufacturing process Methods 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 238000007789 sealing Methods 0.000 claims description 10
- 229920005989 resin Polymers 0.000 claims description 9
- 239000011347 resin Substances 0.000 claims description 9
- 239000004743 Polypropylene Substances 0.000 claims description 7
- 239000002612 dispersion medium Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 7
- -1 polypropylene Polymers 0.000 claims description 7
- 229920001155 polypropylene Polymers 0.000 claims description 7
- 229920001225 polyester resin Polymers 0.000 claims description 4
- 239000004645 polyester resin Substances 0.000 claims description 4
- 230000001954 sterilising effect Effects 0.000 claims description 4
- 238000007599 discharging Methods 0.000 claims description 3
- 238000001746 injection moulding Methods 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 238000003892 spreading Methods 0.000 claims description 3
- 239000000088 plastic resin Substances 0.000 claims description 2
- 229920001169 thermoplastic Polymers 0.000 claims 1
- 239000004416 thermosoftening plastic Substances 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 7
- 239000005977 Ethylene Substances 0.000 description 7
- 239000012510 hollow fiber Substances 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000012528 membrane Substances 0.000 description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 4
- 238000005304 joining Methods 0.000 description 4
- 238000003825 pressing Methods 0.000 description 4
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 4
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 4
- 239000010836 blood and blood product Substances 0.000 description 3
- 229940125691 blood product Drugs 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 206010003445 Ascites Diseases 0.000 description 2
- 241000700605 Viruses Species 0.000 description 2
- XECAHXYUAAWDEL-UHFFFAOYSA-N acrylonitrile butadiene styrene Chemical compound C=CC=C.C=CC#N.C=CC1=CC=CC=C1 XECAHXYUAAWDEL-UHFFFAOYSA-N 0.000 description 2
- 229920000122 acrylonitrile butadiene styrene Polymers 0.000 description 2
- 239000004676 acrylonitrile butadiene styrene Substances 0.000 description 2
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000001631 haemodialysis Methods 0.000 description 2
- 230000000322 hemodialysis Effects 0.000 description 2
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- 238000000926 separation method Methods 0.000 description 2
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- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 1
- 239000004793 Polystyrene Substances 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 239000003463 adsorbent Substances 0.000 description 1
- 229920006127 amorphous resin Polymers 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
- RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 1
- 239000000560 biocompatible material Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
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- 229910052731 fluorine Inorganic materials 0.000 description 1
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- 229920001903 high density polyethylene Polymers 0.000 description 1
- 239000004700 high-density polyethylene Substances 0.000 description 1
- 229910001410 inorganic ion Inorganic materials 0.000 description 1
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- 239000002245 particle Substances 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
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- 229920000515 polycarbonate Polymers 0.000 description 1
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- 229920000728 polyester Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920013716 polyethylene resin Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 239000002952 polymeric resin Substances 0.000 description 1
- 229920005673 polypropylene based resin Polymers 0.000 description 1
- 229920005606 polypropylene copolymer Polymers 0.000 description 1
- 229920002223 polystyrene Polymers 0.000 description 1
- 238000004382 potting Methods 0.000 description 1
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Landscapes
- External Artificial Organs (AREA)
Abstract
Description
本発明は、流体処理用ビーズを収容するためのフィルター付き筒状容器に関する。より詳しくは、本発明は、血液浄化用ビーズを収容するための熱可塑性樹脂製フィルター付き筒状容器であって、該筒状容器を構成するヘッダーと筒状容器本体が該熱可塑性樹脂の溶融により所定の２箇所以上で気密又は液密状態で溶着されている筒状容器に関する。 The present invention relates to a tubular container with a filter for containing beads for fluid treatment. More specifically, the present invention relates to a tubular container with a filter made of a thermoplastic resin for accommodating blood purification beads, wherein a header and a tubular container body forming the tubular container are melted of the thermoplastic resin. The present invention relates to a cylindrical container welded in a predetermined two or more places in an airtight or liquid-tight state.
血液透析、血液透析濾過、血液濾過、血漿分離などの体外循環式の血液浄化処理、腹水などの体腔液処理、血液製剤のウィルス除去・処理などにおいて、リン酸、凝集物、白血球などの好ましくない成分、すなわち、被除去成分を吸着・除去することができる粒状成形体（ビーズ）を充填したモジュールが用いられている。特に、輸血用の全血製剤、赤血球製剤、血小板製剤、血漿製剤などから副作用の原因となる微小凝集物や白血球を除去する目的で、使い捨てのビーズ充填モジュールが用いられている。 In hemodialysis, hemodiafiltration, hemofiltration, plasma separation and other extracorporeal circulation type blood purification, treatment of body fluid such as ascites, removal of virus from blood products, treatment of undesired phosphoric acid, aggregates, white blood cells, etc. A module filled with a granular molded body (beads) capable of adsorbing and removing components, that is, components to be removed is used. In particular, a disposable bead-filling module is used for the purpose of removing microaggregates and white blood cells that cause side effects from whole blood products for transfusion, red blood cell products, platelet products, plasma products and the like.
かかる使い捨てモジュールのハウジング（容器）としては、被充填物がビーズではなく中空糸膜であるものの、筒状容器（ケーシング）本体の両端にＯリングを介してヘッダー（血液導出入部材）を、螺合、接着剤、超音波溶着などの手段により取り付け（締め付け）密閉性を確保するものが知られている（以下の特許文献１参照）。
しかしながら、使い捨てビーズ充填モジュールの容器として、かかるＯリングの使用は比較的高価であり、また、容器本体にヘッダーを取り付け、密閉するという容器の組立プロセスにおいて変形しやすいＯリングの取り付けは、手間がかかるだけでなく、密閉性を確保するための締め付け圧力の管理なども必要になる。さらに、中空糸膜に代えてビーズを充填する場合には、充填されたビーズがヘッダーの血液導出入口から漏れ出すことを防止するためのフィルターを容器内部に保持する必要があるため、組立プロセスにさらに手間がかかるものとなっている。
As a housing (container) of such a disposable module, although the object to be filled is not a bead but a hollow fiber membrane, a header (blood inlet/outlet member) is screwed on both ends of the cylindrical container (casing) body via O-rings. In this case, it is known to secure the attachment (tightening) hermeticity by means such as an adhesive or ultrasonic welding (see Patent Document 1 below).
However, the use of such an O-ring as a container for a disposable bead filling module is relatively expensive, and it is troublesome to attach the O-ring, which is easily deformed in the container assembly process of mounting and sealing the header on the container body. In addition to this, it is also necessary to manage the tightening pressure to ensure the airtightness. Furthermore, when beads are filled in place of the hollow fiber membrane, it is necessary to hold a filter inside the container to prevent the filled beads from leaking out from the blood outlet of the header. It is even more troublesome.
以下の特許文献２には、被充填物がビーズではなく中空糸膜であるものの、筒状容器本体の両端にＯリングを介さずにヘッダーを超音波溶着により溶着して密閉性を確保するものが開示されている。しかしながら、特許文献２には、ヘッダーを筒状容器本体に対して相対的に押し込みながら超音波溶着するシェアジョイントにおいて、押し込み止めを形成することにより、中空糸膜のポッティング部の破損を防止する技術が開示されているにすぎない。
また、特許文献３には、溶着部がシェアジョイント構造であると、ヘッダー押し込み時にヘッダーが広がり、容器本体側面が滑り、一定の圧力で加圧力が低下し、一定の位置で超音波エネルギーを集中することができず、溶融量が低下し、耐圧強度が低下するという問題があるところ、ヘッダーと筒状容器本体との超音波溶着において少なくとも２箇所の領域を順次溶着して、ヘッダーと筒状容器本体との接合強度を向上し、液漏れや耐圧強度不足を解決する技術が開示されている。しかしながら、特許文献３では、上記少なくとも２箇所の領域は、ヘッダー突出部の同一面に存在し、また、充填物が中空糸膜であるため、容器内部のどの位置でフィルターを保持しているかの開示はなく、超音波溶着のために適用される超音波エネルギーがフィルター部材の破損に及ぼす影響についても全く検討されていない。
In Patent Document 2 below, although the material to be filled is not a bead but a hollow fiber membrane, a header is ultrasonically welded to both ends of the cylindrical container body without an O-ring to ensure hermeticity. Is disclosed. However, in Patent Document 2, in a shear joint in which ultrasonic welding is performed while pressing the header relative to the tubular container body, a technology for preventing damage to the potting portion of the hollow fiber membrane by forming a pressing stop. Is only disclosed.
Further, in Patent Document 3, if the welded portion has a shear joint structure, the header expands when the header is pushed in, the side surface of the container body slides, the applied pressure decreases at a certain pressure, and the ultrasonic energy is concentrated at a certain position. However, there is a problem that the melting amount is reduced and the compressive strength is reduced. Therefore, in ultrasonic welding of the header and the tubular container body, at least two regions are sequentially welded to form the header and the tubular container. A technique has been disclosed in which the joint strength with the container body is improved to solve liquid leakage and insufficient pressure resistance. However, in Patent Document 3, the above-mentioned at least two regions are present on the same surface of the header protruding portion, and since the filler is a hollow fiber membrane, which position inside the container holds the filter. There is no disclosure, and the effect of ultrasonic energy applied for ultrasonic welding on the breakage of the filter member is not examined at all.
前記した従来技術の問題点に鑑み、本発明が解決しようとする課題は、血液浄化等に用いるビーズを収容するためのフィルター付き使い捨て筒状容器において、比較的高価なＯリングを用いず低コストであり、かつ、締め付け等の管理が不要であり、容器内部に保持されるフィルターを破損せず（例えば、ヘッダーと筒状容器本体との間の溶着時にフィルターが脱落し、剥がれてしまうということ回避しつつ）、十分な密閉性を有し、組み立てに手間がかからず、さらに組み立てを自動化することができる熱可塑性樹脂製筒状容器を提供することである。 In view of the above-mentioned problems of the prior art, the problem to be solved by the present invention is to provide a disposable cylindrical container with a filter for accommodating beads used for blood purification or the like at a low cost without using a relatively expensive O-ring. Moreover, it does not require management such as tightening, and does not damage the filter held inside the container (for example, the filter may fall off when it is welded between the header and the tubular container body, and peel off). It is to provide a tubular container made of a thermoplastic resin, which has a sufficient hermeticity, requires less labor for assembly, and can be automated in assembly while avoiding it.
本願発明者らは、前記課題を解決すべく鋭意検討し実験を重ねた結果、ヘッダーと筒状容器本体との接合において、ヘッダー又は筒状容器本体のいずれかに中心軸（Ｐ）断面において略矩形の突出部を設け、該突出部内周面の周方向全体及び外周面の周方向全体において、気密又は液密状態で熱可塑性樹脂の溶融により溶着することにより、前記課題を解決しうることを見出し、本発明を完成するに至ったものである。 As a result of intensive studies and experiments to solve the above-mentioned problems, the inventors of the present application have found that, in the joint between the header and the tubular container body, either the header or the tubular container body has a substantially central axis (P) cross section. Providing a rectangular protrusion, in the entire circumferential direction of the inner peripheral surface of the protrusion and the entire circumferential direction of the outer peripheral surface, by welding by melting the thermoplastic resin in an airtight or liquid-tight state, it is possible to solve the above problems. It was found that the present invention has been completed.
すなわち、本発明は以下のとおりのものである。
［１］流体処理用ビーズを収納するためのフィルター付き熱可塑性樹脂製筒状容器（１）であって、該筒状容器（１）は、その側面に該ビーズを充填するための充填口（２０）を有する略円形断面の筒状容器本体（２）、該ビーズを該容器内に保持するためのフィルター付きリング（４）、及び該筒状容器本体（２）の両端に配置され、流体出入口（５０）を有するヘッダー（５）から構成され、該ヘッダー（５）は、該筒状容器本体（２）に向かって突出する中心軸（Ｐ）断面において略矩形状のヘッダー突出部（５２）を有し、かつ、該筒状容器本体（２）は、該ヘッダー突出部（５２）を受容し、これと嵌合する陥凹部を有するか、又は、該筒状容器本体（２）は、該ヘッダー（５）に向かって突出する中心軸（Ｐ）断面において略矩形状の筒状容器本体突出部を有し、かつ、該ヘッダー（５）は、該筒状容器本体突出部を受容し、これと嵌合する陥凹部を有するかのいずれかであり、そして少なくとも、該ヘッダー突出部（５２）又は該筒状容器本体突出部の内周面の周方向全体（Ａ）及び外周面の周方向全体（Ｂ）において、該ヘッダー（５）と該筒状容器本体（２）とが、該フィルター付きリング（４）を保持しつつ、気密又は液密状態で該熱可塑性樹脂の溶融により溶着されていることを特徴とする前記筒状容器。
［２］前記ヘッダー（５）は、前記筒状容器本体（２）に向けて突出する中心軸（Ｐ）断面において略矩形状のヘッダー突出部（５２）を有し、かつ、該筒状容器本体（２）は、該ヘッダー突出部（５２）を受容し、これと嵌合する陥凹部を有し、該陥凹部は、該ヘッダー突出部（５２）の内側に配置される中心軸（Ｐ）断面において略矩形状の筒状容器本体突出部（２３）と外側に配置される中心軸（Ｐ）断面において略矩形状の容器本体突出部（２２）とで構成される、前記［１］に記載の筒状容器。
［３］前記内側の筒状容器本体突出部（２３）の先端が、前記ヘッダー突出部（５２）の内側にある、該筒状容器（１）の中心軸（Ｐ）に対して垂直の環状の平坦面（５３）に当接し、及び／又は、前記外側の筒状容器本体突出部（２２）の先端が、前記ヘッダー突出部（５２）の外側にある、該筒状容器（１）の中心軸（Ｐ）に対して垂直の環状の平坦面（５４）に当接し、及び／又は前記ヘッダー突出部（５２）の先端が、前記外側の筒状容器本体突出部（２２）と前記内側の筒状容器本体突出部（２３）の間にある中心軸（Ｐ）に対して垂直の環状の平坦面（２４）に当接する、前記［２］に記載の筒状容器。
［４］前記フィルター付きリング（４）は、フィルター（４０）が、中心軸（Ｐ）断面において略矩形の熱可塑性樹脂製環状リング（４１）に該リング（４１）の筒状容器本体（２）側面で、該熱可塑性樹脂の溶融により溶着されたものであり、該リング（４１）の外周面（４１ｂ）は、前記内側の筒状容器本体突出部（２３）の内周面（２３ａ）に対向し、該環状リング（４１）のヘッダー側の中心軸（Ｐ）に対して垂直の環状の平坦面（４１ｃ）は、前記ヘッダー突出部（５２）の内側にある中心軸（Ｐ）に対して垂直の環状の平坦面（５３）と対向し、該平坦面（５３）の内側からフィルター付きリング（４）側に向かって突出するヘッダー突出部（５５）の外周面（５５ｂ）は、該リングの内周面（４１ａ）に対向し、さらに該リングの平坦面（４１ｃ）と反対側の略平坦面が、前記内側の筒状容器本体突出部の内側にある中心軸（Ｐ）に対して垂直の環状の平坦面（２５）に対向して、配置されることにより、該ヘッダー（５）と該筒状容器本体（２）との間で、保持されている、前記［２］又は［３］に記載の筒状容器。
［５］前記筒状容器本体（２）、前記ヘッダー（５）、及び前記フィルター付きリング（４）のリング（４１）を構成する熱可塑性樹脂が、同種のポリプロピレン系樹脂である、前記［２］〜［４］のいずれかに記載の筒状容器。
［６］前記フィルター付きリング（４）を構成するフィルター（４０）が、ポリエステル系樹脂のメッシュであり、該フィルター付きリング（４）のリング（４１）を構成するポリプロピレン系樹脂の溶融により埋め込まれて溶着され、該筒状容器本体（２）側に略平坦面が形成されている、前記［４］又は［５］に記載の筒状容器。
［７］前記ヘッダー（５）と前記筒状容器本体（２）とを、前記フィルター付きリング（４）を保持しつつ、該ヘッダーの径方向に広がる板状の天面部（５１）に超音波ホーン（１００）を押し当てる超音波溶着により、気密又は液密状態で、前記熱可塑性樹脂の溶融により溶着する工程を含む、前記［１］〜［６］のいずれかに記載の筒状容器の製造方法。
［８］前記ヘッダー（５）、及び／又は前記筒状容器本体（２）を射出成形により製造する工程を含む、前記［７］に記載の方法。
［９］前記［１］〜［６］のいずれかに記載の筒状容器（１）又は前記［７］若しくは［８］に記載の方法により製造された筒状容器（１）の筒状容器本体（２）の側面にある充填口（２０）から、分散媒に分散された血液浄化処理用ビーズを注入し、ヘッダー（５）の流体出入口（５０）から、該分散媒を排出する工程、該流体出入口（５０）を仮封止した後、該充填口（２０）から封入液を注入し、該筒状容器本体（２）の内周面（２６）と該充填口（２０）の内壁とで画される空間に弾性体（３１）を詰めて、該筒状容器本体（２）の内周面（２６）を面一にした後に、該充填口（２０）をキャップ（３）で封止する工程、次いで、これを包装した後、ガンマ線で滅菌処理する工程を含む、血液浄化処理用ビーズが充填された血液浄化処理モジュールの製造方法。
That is, the present invention is as follows.
[1] A tubular container (1) made of a thermoplastic resin with a filter for storing beads for fluid treatment, wherein the tubular container (1) has a filling port ( 20) having a substantially circular cross-section, a tubular container body (2), a ring (4) with a filter for holding the beads in the container, and a fluid container disposed at both ends of the tubular container body (2). It is composed of a header (5) having an inlet/outlet port (50), and the header (5) has a substantially rectangular header projection (52) in a central axis (P) cross section which projects toward the tubular container body (2). ), and the tubular container body (2) has a recess for receiving and fitting the header protrusion (52), or the tubular container body (2) is A cylindrical container body protruding portion having a substantially rectangular shape in a central axis (P) section protruding toward the header (5), and the header (5) receiving the cylindrical container body protruding portion. And has at least one recessed portion that fits with this, and at least the entire circumferential direction (A) and the outer circumferential surface of the inner peripheral surface of the header protrusion (52) or the cylindrical container body protrusion. In the entire circumferential direction (B), the header (5) and the tubular container body (2) melt the thermoplastic resin in an airtight or liquid-tight state while holding the ring (4) with a filter. The cylindrical container is welded by
[2] The header (5) has a header protruding portion (52) having a substantially rectangular shape in a central axis (P) section protruding toward the cylindrical container body (2), and the cylindrical container The main body (2) has a recess for receiving and fitting the header protrusion (52), and the recess has a central axis (P) arranged inside the header protrusion (52). ) A container body protrusion (23) having a substantially rectangular cross section and a container body protrusion (22) having a substantially rectangular cross section on the central axis (P) arranged on the outside [1]. The cylindrical container according to.
[3] An annular shape in which the tip of the inner cylindrical container main body protrusion (23) is inside the header protrusion (52) and is perpendicular to the central axis (P) of the cylindrical container (1). Of the cylindrical container (1), which is in contact with the flat surface (53) of the cylindrical container (1), and/or the tip of the protruding part (22) of the outer cylindrical container body is outside the header protruding part (52). It abuts on an annular flat surface (54) perpendicular to the central axis (P), and/or the tip of the header protrusion (52) is connected to the outer cylindrical container body protrusion (22) and the inner side. The tubular container according to the above [2], which abuts on an annular flat surface (24) perpendicular to the central axis (P) between the tubular container main body protrusions (23).
[4] In the ring with filter (4), the filter (40) is a tubular container body (2) of a ring-shaped ring (41) made of a thermoplastic resin, which is substantially rectangular in cross section of the central axis (P). ) The side surface is welded by melting of the thermoplastic resin, and the outer peripheral surface (41b) of the ring (41) is the inner peripheral surface (23a) of the inner cylindrical container main body protrusion (23). The annular flat surface (41c) facing the central axis (P) of the annular ring (41) on the header side is aligned with the central axis (P) inside the header protrusion (52). On the other hand, the outer peripheral surface (55b) of the header projecting portion (55), which faces the vertical annular flat surface (53) and projects from the inside of the flat surface (53) toward the ring with filter (4), A substantially flat surface opposite to the inner peripheral surface (41a) of the ring and opposite to the flat surface (41c) of the ring is aligned with the central axis (P) inside the cylindrical container main body protrusion on the inner side. [2], which is held between the header (5) and the tubular container body (2) by being arranged so as to face the vertical annular flat surface (25). Alternatively, the cylindrical container according to [3].
[5] The thermoplastic resin forming the tubular container body (2), the header (5), and the ring (41) of the ring (4) with a filter is a polypropylene resin of the same kind, [2] ] The cylindrical container in any one of [4].
[6] The filter (40) constituting the ring with filter (4) is a mesh of polyester resin and is embedded by melting the polypropylene resin constituting the ring (41) of the ring with filter (4). The tubular container according to the above [4] or [5], wherein the tubular container is welded to form a substantially flat surface on the tubular container body (2) side.
[7] An ultrasonic wave is applied to the header (5) and the tubular container body (2) on a plate-shaped top surface portion (51) spreading in the radial direction of the header while holding the ring with filter (4). The tubular container according to any one of [1] to [6], including a step of welding by melting the thermoplastic resin in an airtight or liquid-tight state by ultrasonic welding with a horn (100) pressed against it. Production method.
[8] The method according to [7] above, including a step of manufacturing the header (5) and/or the tubular container body (2) by injection molding.
[9] The cylindrical container (1) according to any one of [1] to [6] or the cylindrical container (1) manufactured by the method according to [7] or [8]. A step of injecting blood purification beads dispersed in a dispersion medium from a filling port (20) on the side surface of the main body (2) and discharging the dispersion medium from a fluid inlet/outlet port (50) of the header (5); After the fluid inlet/outlet port (50) is temporarily sealed, an enclosed liquid is injected from the filling port (20) to form an inner peripheral surface (26) of the tubular container body (2) and an inner wall of the filling port (20). After the elastic body (31) is packed in the space defined by and the inner peripheral surface (26) of the cylindrical container body (2) is made flush, the filling port (20) is closed by the cap (3). A method of manufacturing a blood purification treatment module filled with beads for blood purification treatment, which comprises a step of sealing, a step of packaging the same, and a step of sterilizing with gamma rays.
本発明に係る流体処理用ビーズを収納するためのフィルター付き熱可塑性樹脂製筒状容器は、ヘッダーと筒状容器本体との接合において、ヘッダー又は筒状容器本体のいずれかに中心軸（Ｐ）断面において略矩形の突出部を設け、該突出部内周面の周方向全体及び外周面の周方向全体において（すなわち、少なくとも２箇所の領域）で気密又は液密状態で熱可塑性樹脂の溶融により溶着されており、かつ、適用する超音波エネルギーを制御して、例えば、過度なエネルギーによる超音波ホーン接触面への傷の発生や溶着機の出力不足によるオーバーロード発生を回避しつつ、容器内部に保持されるフィルターを破損せずに、例えば、ヘッダーと筒状容器本体との間の溶着時にフィルターが脱落し、剥がれてしまうということ回避しつつ、十分な密閉性を確保することができ、また、比較的高価なＯリングを用いず低コストであり、かつ、締め付け等の管理が不要であり、組み立てに手間がかからず、さらに組み立てを自動化することができるものである。 A tubular container made of a thermoplastic resin with a filter for accommodating a bead for fluid treatment according to the present invention has a central axis (P) at either the header or the tubular container body at the joining of the header and the tubular container body. A protrusion having a substantially rectangular cross section is provided, and the thermoplastic resin is welded in an airtight or liquid-tight state in the entire circumferential direction of the inner circumferential surface of the projecting portion and the entire circumferential direction of the outer circumferential surface (that is, at least two regions). And, by controlling the applied ultrasonic energy, for example, while avoiding the occurrence of damage to the ultrasonic horn contact surface due to excessive energy and the occurrence of overload due to insufficient output of the welding machine, Without damaging the retained filter, for example, while avoiding that the filter falls off and peels off during welding between the header and the tubular container body, it is possible to ensure sufficient airtightness. The present invention is low in cost without using a relatively expensive O-ring, requires no management such as tightening, does not require much labor for assembling, and can further automate the assembling.
以下、添付図面を参照して、本発明の実施形態を詳細に説明する。尚、同一の要素には同一の符号を付し、重複する説明を省略する場合がある。また、上下左右等の位置関係は、特に断らない限り、図面に示す位置関係に基づくものとし、図面の寸法比率は、図示の比率に限定されるものではない。さらに、以下の実施形態は、本発明を説明するための例示であり、本発明はかかる実施形態に限定されるものではない。 Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings. In addition, the same elements may be denoted by the same reference numerals, and redundant description may be omitted. Further, unless otherwise specified, the positional relationship such as top, bottom, left, and right is based on the positional relationship shown in the drawings, and the dimensional ratio of the drawings is not limited to the illustrated ratio. Furthermore, the following embodiments are examples for explaining the present invention, and the present invention is not limited to the embodiments.
本実施形態の筒状容器は、流体処理用ビーズを収納するためのフィルター付き熱可塑性樹脂製筒状容器（１）であって、該筒状容器（１）は、その側面に該ビーズを充填するための充填口（２０）を有する略円形断面の筒状容器本体（２）、該ビーズを該容器内に保持するためのフィルター付きリング（４）、及び該筒状容器本体（２）の両端に配置され、流体出入口（５０）を有するヘッダー（５）から構成され、該ヘッダー（５）は、該筒状容器本体（２）に向かって突出する中心軸（Ｐ）断面において略矩形状のヘッダー突出部（５２）を有し、かつ、該筒状容器本体（２）は、該ヘッダー突出部（５２）を受容し、これと嵌合する陥凹部を有するか、又は、該筒状容器本体（２）は、該ヘッダー（５）に向かって突出する中心軸（Ｐ）断面において略矩形状の筒状容器本体突出部を有し、かつ、該ヘッダー（５）は、該筒状容器本体突出部を受容し、これと嵌合する陥凹部を有するかのいずれかであり、そして少なくとも、該ヘッダー突出部（５２）又は該筒状容器本体突出部の内周面の周方向全体（Ａ）及び外周面の周方向全体（Ｂ）において、該ヘッダー（５）と該筒状容器本体（２）とが、該フィルター付きリング（４）を保持しつつ、気密又は液密状態で該熱可塑性樹脂の溶融により溶着されていることを特徴とする。
本実施形態の筒状容器に収納される流体処理用ビーズは、その用途、形状、大きさ等に関して特に制限されないが、例えば、リン、ホウ素、フッ素、ヒ素等を除去するための有機高分子樹脂及び無機イオン吸着体を含む、平均粒形１００〜２５００μｍの球状粒子形態の多孔性成形体であることができる。
The tubular container of the present embodiment is a thermoplastic resin tubular container (1) with a filter for accommodating beads for fluid treatment, and the tubular container (1) is filled with the beads on its side surface. A tubular container body (2) having a substantially circular cross section having a filling port (20) for holding the beads, a ring (4) with a filter for holding the beads in the container, and the tubular container body (2). The header (5) is arranged at both ends and has a fluid inlet/outlet port (50), and the header (5) has a substantially rectangular shape in a central axis (P) section protruding toward the tubular container body (2). Or the tubular container body (2) has a recess for receiving the header protrusion (52) and fitting with the header protrusion (52). The container body (2) has a cylindrical container body projecting portion that is substantially rectangular in the central axis (P) cross section that projects toward the header (5), and the header (5) has the tubular shape. Either of the recesses for receiving and fitting the container body protrusion, and at least the header protrusion (52) or the entire inner circumferential surface of the cylindrical container body protrusion in the circumferential direction. (A) and the entire circumferential direction (B) of the outer peripheral surface, the header (5) and the tubular container body (2) are in an airtight or liquid-tight state while holding the ring with filter (4). It is characterized in that it is welded by melting the thermoplastic resin.
The beads for fluid treatment accommodated in the cylindrical container of the present embodiment are not particularly limited in terms of use, shape, size, etc., but are, for example, an organic polymer resin for removing phosphorus, boron, fluorine, arsenic and the like. And an inorganic ion adsorbent, which can be a porous molded body in the form of spherical particles having an average particle shape of 100 to 2500 μm.
［筒状容器］
図１、２に示すように、本実施形態の筒状容器（１）は、流体処理用ビーズを収納するためのフィルター付き熱可塑性樹脂製筒状容器であって、該筒状容器（１）は、その側面に該ビーズを充填するための充填口（２０）を有する略円形断面の筒状容器本体（２）、及び該筒状容器本体（２）の両端に配置され、流体出入口（５０）を有するヘッダー（５）から構成され、その内部に流体処理用ビーズが充填され、その後、封入液で満たされ、筒状容器本体（２）の内周面（２６）と充填口（２０）の内壁とで画される空間に弾性体（３１）を詰めて筒状容器本体（２）の内周面（２６）を面一にした後に、充填口（２０）がキャップ（３）で封止され（図２、４参照）、滅菌処理された流体処理用モジュールは、ネジ構造を有する流体出入口（５０）に外部チューブ（配管）（図示せず）を接続することで、例えば、血液浄化モジュールとして使用される。
筒状容器（１）の内部には、流体処理用ビーズが充填されるため、図２に示すように、フィルター付きリング（４）（図５参照）をヘッダー（５）付近に配置して、モジュールの使用時に、ヘッダーの流体出入口（５０）から流体処理用ビーズが漏れ出ないようにする必要がある。尚、ビーズ充填後におけるビーズ充填口（２０）へのキャップ（３）の取り付け（封止）手段は、特に制限されず、筒状容器本体（２）とキャップ（３）を同素材である熱可塑性樹脂製として溶着することが、生産コスト、密封の確実性、汚染防止の観点等から好ましい。尚、筒状容器本体（２）の内周面（２６）と充填口（２０）の内壁とで画される空間に弾性体（３１）を詰めて筒状容器本体（２）の内周面（２６）を面一にする理由は、ビーズがこの空間に入り込み、流体が偏流することによる処理効率の低下や、処理流体の漏れを回避する等のためである（図４参照）。
[Cylindrical container]
As shown in FIGS. 1 and 2, the tubular container (1) of the present embodiment is a tubular container made of a thermoplastic resin with a filter for storing beads for fluid treatment, and the tubular container (1) Are arranged at both ends of the cylindrical container body (2) having a substantially circular cross section having a filling port (20) for filling the beads on its side surface, and the fluid inlet/outlet port (50). ) Having a header (5), the inside of which is filled with beads for fluid treatment and then filled with a filling liquid, and the inner peripheral surface (26) of the cylindrical container body (2) and the filling port (20). After filling the space defined by the inner wall of the container with the elastic body (31) to make the inner peripheral surface (26) of the cylindrical container body (2) flush, the filling port (20) is sealed with the cap (3). The fluid treatment module that has been stopped (see FIGS. 2 and 4) and sterilized is connected to an external tube (pipe) (not shown) to the fluid inlet/outlet (50) having a screw structure, for example, blood purification. Used as a module.
Since the beads for fluid treatment are filled inside the cylindrical container (1), the ring with filter (4) (see FIG. 5) is arranged near the header (5) as shown in FIG. When using the module, it is necessary to prevent the fluid processing beads from leaking out from the fluid inlet/outlet port (50) of the header. The means for attaching (sealing) the cap (3) to the bead filling port (20) after bead filling is not particularly limited, and the tubular container body (2) and the cap (3) are made of the same material. It is preferable to weld the resin as a plastic resin from the viewpoints of production cost, sealing reliability, contamination prevention, and the like. The inner peripheral surface of the cylindrical container body (2) is filled with an elastic body (31) in a space defined by the inner peripheral surface (26) of the cylindrical container body (2) and the inner wall of the filling port (20). The reason why (26) is made flush is to prevent the processing efficiency from being reduced due to the beads entering into this space and causing the fluid to flow unevenly, and to prevent the processing fluid from leaking (see FIG. 4).
［筒状容器本体の構造］
図２、３、４、６に示すように、筒状容器本体（２）の端部は、径方向に広がる板状の天面部（２１）を有し、ヘッダー（５）に向かって中心軸（Ｐ）断面において略矩形の２重に円筒状に突出する容器突出部としての内側突出部（２３）と他の容器突出部としての外側突出部（２２）とを有している。内側突出部（２３）と外側突出部（２２）は、それぞれ、中心軸（Ｐ）を軸心とする円筒形状を有し、同心円状に配置されている。中心軸（Ｐ）方向の内側突出部（２３）の突出長さは、外側突出部（２２）の突出長さと同じであることができる。内側突出部（２３）外側突出部（２２）の間には、中心軸（Ｐ）に対して垂直の環状の平坦部（２４）が存在し、内側突出部（２３）の内側に、中心軸（Ｐ）に対して垂直の環状の平坦部（２５）が存在する。この平坦部（２５）は、筒状容器本体（２）の内周面（２６）と垂直に交わり、以下に説明するように、フィルター付きリング（４）の外周縁に接合されたリング（４１）のフィルター側の略平坦面（４１ｄ）と接して配置されることができる。
図６に示すように、１の態様においては、ヘッダー（５）は、筒状容器本体（２）に向けて突出する中心軸（Ｐ）断面において略矩形状のヘッダー突出部（５２）を有し、かつ、該筒状容器本体（２）は、該ヘッダー突出部（５２）を受容し、これと嵌合する陥凹部を有し、該陥凹部は、該ヘッダー突出部（５２）の内側に配置される中心軸（Ｐ）断面において略矩形状の筒状容器本体突出部（２３）と外側に配置される径方向断面において略矩形状の容器本体突出部（２２）とで構成されることができる。
[Structure of cylindrical container body]
As shown in FIGS. 2, 3, 4, and 6, the end portion of the tubular container body (2) has a plate-shaped top surface portion (21) that spreads in the radial direction, and has a central axis toward the header (5). It has an inner protruding portion (23) as a container protruding portion that protrudes in a substantially rectangular double shape in a cross section (P) and an outer protruding portion (22) as another container protruding portion. The inner protruding portion (23) and the outer protruding portion (22) each have a cylindrical shape with the central axis (P) as an axis, and are arranged concentrically. The protrusion length of the inner protrusion (23) in the direction of the central axis (P) may be the same as the protrusion length of the outer protrusion (22). An annular flat portion (24) perpendicular to the central axis (P) exists between the inner protruding portion (23) and the outer protruding portion (22), and the central axis is formed inside the inner protruding portion (23). There is an annular flat portion (25) perpendicular to (P). The flat portion (25) intersects the inner peripheral surface (26) of the tubular container body (2) perpendicularly, and as described below, the ring (41) joined to the outer peripheral edge of the ring (4) with a filter. ) Can be placed in contact with the substantially flat surface (41d) on the filter side.
As shown in FIG. 6, in one aspect, the header (5) has a substantially rectangular header projection (52) in the central axis (P) cross section that projects toward the tubular container body (2). And the tubular container body (2) has a recess for receiving and fitting the header protrusion (52), the recess being on the inside of the header protrusion (52). A cylindrical container body protrusion (23) having a substantially rectangular cross section in the central axis (P) and a substantially rectangular container body protrusion (22) having a substantially rectangular cross section in the outer radial direction. be able to.
［ヘッダーの構造］
ヘッダー（５）は、筒状容器本体（２）の両端部に蓋材として配置される。ヘッダー（５）は、通常、中心軸（Ｐ）上に設けられ流体出入口（管状ノズル）（５０）と、環状ノズル（５０）から径方向に広がる板状の天面部（５１）と、該天面部（５１）の外周縁付近から筒状容器本体（２）側に向かって突出するヘッダー突出部（５２）を有している。
図４に示すように、環状ノズル（５０）は、外部チューブを接続するためのネジ構造を有している。ヘッダー突出部（５２）の外側には、中心軸（Ｐ）に対して垂直の環状の外側平坦面（５４）、内側には、中心軸（Ｐ）に対して垂直の環状の内側平坦面（５３）が、それぞれ、存在する。図６に示す態様では、この内側平坦面（５３）は、環状ノズル（５０）から筒状容器本体（２）の端部に向かって次第に径が大きくなる内面と繋がっているが、内側平坦面（５３）の内側からフィルター付きリング（４）側に向かって突出するヘッダー突出部（５５）を設けている。
[Header structure]
The header (5) is arranged as a lid member at both ends of the tubular container body (2). The header (5) is usually provided on the central axis (P) and has a fluid inlet/outlet port (tubular nozzle) (50), a plate-shaped top surface portion (51) spreading radially from the annular nozzle (50), and the ceiling. It has a header protruding portion (52) protruding from the vicinity of the outer peripheral edge of the surface portion (51) toward the cylindrical container body (2) side.
As shown in FIG. 4, the annular nozzle (50) has a screw structure for connecting an outer tube. On the outside of the header protrusion (52), an annular outer flat surface (54) perpendicular to the central axis (P), and on the inside, an annular inner flat surface (perpendicular to the central axis (P) ( 53) exist, respectively. In the embodiment shown in FIG. 6, the inner flat surface (53) is connected to the inner surface whose diameter gradually increases from the annular nozzle (50) toward the end of the tubular container body (2). A header projecting portion (55) projecting from the inside of (53) toward the ring with filter (4) is provided.
［ヘッダーと筒状容器本体の接合構造］
図６、７に示すように、中心軸（Ｐ）断面において略矩形のヘッダー突出部（５２）は、筒状容器本体の内側突出部（２３）と外側突出部（２２）の間に嵌合するように当接された後に、超音波ホーン（１００）をヘッダー天面部（５１）に押し付けることにより超音波溶着されることができる。ここで、筒状容器本体の外側突出部（２２）と内側突出部（２３）中心軸（Ｐ）方向の突出長さは略同じであることができ、外側突出部（２２）の先端にある中心軸（Ｐ）に対して垂直な環状の平坦面（２２ｃ）が、ヘッダー突出部の外側の平坦面（５４）に当接するか、又は、内側突出部（２３）の先端にある中心軸（Ｐ）に対して垂直な環状の平坦面（２３ｃ）が、ヘッダー突出部の内側の平坦面（５３）に当接するかのいずれでもよく、あるいは、ヘッダー突出部（５２）の突出長さが、筒状容器本体の外側突出部（２２）又は内側突出部（２３）の突出長さよりも長く、ヘッダー突出部の先端にある中心軸（Ｐ）に対して垂直な環状の平坦面（５２ｃ）が、筒状容器本体の外側突出部（２２）と内側突出部（２３）の間にある中心軸（Ｐ）に対して垂直な環状の平坦面（２４）に当接してもよい。いずれの場合でも、超音波溶着時には、ヘッダー（５）と筒状容器本体（２）とは、平坦面が向かい合うように当接されるため、溶着時におけるヘッダー（５）又は筒状容器本体（２）の変形は起こりにくい。
[Joining structure of header and tubular container body]
As shown in FIGS. 6 and 7, the header protrusion (52) having a substantially rectangular shape in the central axis (P) cross section is fitted between the inner protrusion (23) and the outer protrusion (22) of the tubular container body. Then, the ultrasonic horn (100) can be ultrasonically welded by pressing it against the header top surface portion (51). Here, the protruding lengths of the outer protruding portion (22) and the inner protruding portion (23) in the central axis (P) direction of the tubular container main body may be substantially the same, and are located at the tip of the outer protruding portion (22). An annular flat surface (22c) perpendicular to the central axis (P) abuts the outer flat surface (54) of the header protrusion or a central axis (at the tip of the inner protrusion (23) ( The annular flat surface (23c) perpendicular to P) may abut on the inner flat surface (53) of the header protrusion, or the protrusion length of the header protrusion (52) may be An annular flat surface (52c) longer than the protruding length of the outer protruding portion (22) or the inner protruding portion (23) of the cylindrical container body and perpendicular to the central axis (P) at the tip of the header protruding portion is provided. Alternatively, it may abut on an annular flat surface (24) that is perpendicular to the central axis (P) between the outer protruding portion (22) and the inner protruding portion (23) of the tubular container body. In any case, during ultrasonic welding, the header (5) and the tubular container body (2) are brought into contact with each other so that their flat surfaces face each other. Therefore, the header (5) or the tubular container body ( The deformation of 2) does not easily occur.
本実施形態においては、ヘッダー突出部（５２）の外周面（５２ｂ）と、筒状容器本体の外側突出部（２２）の内周面（２２ａ）とが近接し、及び、ヘッダー突出部（５２）の内周面（５２ａ）と、筒状容器本体の内側突出部（２３）の外周面（２３ｂ）とが近接し、少なくともこれらの２箇所で、周方向全体で、ヘッダー（５）と筒状容器本体（２）とが、フィルター付きリング（４）を保持しつつ、気密又は液密状態で該熱可塑性樹脂の溶融により溶着されていることが必要である。本実施形態においては、このように、ヘッダー突出部（５２）の内周面（５２ａ）と外周面（５２ｂ）という、ヘッダー突出部（５２）の先端にある中心軸（Ｐ）に対して垂直な環状の平坦面（５２ｃ）を隔てて分離された異なる２つの面において、周方向全体に溶着されていることで、モジュールの使用時における圧力に耐えうる気密・液密状態を確保することができる。また、以下に説明するように、フィルター（４０）の外周縁に接合されたリング（４１）は、筒状容器本体（２）の内側突出部（２３）の内側に、すなわち、内側突出部（２３）を隔てて、上記溶着面から離れて配置されるために、超音波溶着のエネルギーが大きすぎた場合にリング接合部が溶融し、フィルターが脱落し（剥がれてしまう）という問題が生じにくい。 In the present embodiment, the outer peripheral surface (52b) of the header protrusion (52) and the inner peripheral surface (22a) of the outer protrusion (22) of the tubular container body are close to each other, and the header protrusion (52). ), the inner peripheral surface (52a) and the outer peripheral surface (23b) of the inner protruding portion (23) of the cylindrical container body are close to each other, and the header (5) and the cylinder are formed at least at these two positions in the entire circumferential direction. It is necessary that the container body (2) is welded by melting the thermoplastic resin in an airtight or liquid-tight state while holding the ring with filter (4). In the present embodiment, as described above, the inner peripheral surface (52a) and the outer peripheral surface (52b) of the header protrusion (52) are perpendicular to the central axis (P) at the tip of the header protrusion (52). Since the two different surfaces separated by the annular flat surface (52c) are welded in the entire circumferential direction, it is possible to secure an air-tight and liquid-tight state capable of withstanding the pressure when the module is used. it can. Further, as described below, the ring (41) joined to the outer peripheral edge of the filter (40) is inside the inner protruding portion (23) of the tubular container body (2), that is, the inner protruding portion ( Since it is arranged apart from the above-mentioned welding surface by separating 23), the problem that the ring joint melts when the energy of ultrasonic welding is too large and the filter falls off (is peeled off) is unlikely to occur. ..
［フィルターの構造、配置］
図４、５、６、７に示すように、フィルター付きリング（４）は、フィルター（４０）が、中心軸（Ｐ）断面において略矩形の熱可塑性樹脂製環状リング（４１）に該リング（４１）の筒状容器本体（２）側面で、該熱可塑性樹脂の溶融により溶着されたものであることができる。例えば、図２、５に示すように、フィルター付きリング（４）を構成するフィルター（４０）は、ポリエステル系樹脂のメッシュであり、該リング（４１）を構成するポリプロピレン系樹脂の溶融により埋め込まれて溶着され、該筒状容器本体（２）側に略平坦面（４１ｄ）が形成されたものであることができる。より低い溶融温度のポリプロピレン系樹脂にポリエステル系樹脂のメッシュが埋め込まれて溶着されていることにより、リング（４１）からのフィルター（４０）の脱落や、剥がれを防止することができる。
このようなフィルター付きリング（４）は、図６、７に示すように配置され、ヘッダー（５）と筒状容器本体（２）との間に保持されることができる。例えば、リング（４１）の外周面（４１ｂ）は、内側の筒状容器本体突出部（２３）の内周面（２３ａ）に対向し、環状リング（４１）のヘッダー側の中心軸（Ｐ）に対して垂直の環状の平坦面（４１ｃ）は、ヘッダー突出部（５２）の内側にある中心軸（Ｐ）に対して垂直の環状の平坦面（５３）と対向し、該平坦面（５３）の内側からフィルター付きリング（４）側に向かって突出するヘッダー突出部（５５）の外周面（５５ｂ）は、該リングの内周面（４１ａ）に対向し、さらに該リングの平坦面（４１ｃ）と反対側の略平坦面（４１ｄ）は、前記内側の筒状容器本体突出部の内側にある中心軸（Ｐ）に対して垂直の環状の平坦面（２５）に対向して配置されることができる。
[Filter structure and placement]
As shown in FIGS. 4, 5, 6, and 7, in the ring with filter (4), the filter (40) is attached to the annular ring (41) made of a thermoplastic resin having a substantially rectangular shape in the cross section of the central axis (P). The side surface of the tubular container body (2) of 41) may be welded by melting the thermoplastic resin. For example, as shown in FIGS. 2 and 5, the filter (40) that constitutes the ring with filter (4) is a mesh of polyester resin and is embedded by melting the polypropylene resin that constitutes the ring (41). And a substantially flat surface (41d) is formed on the cylindrical container body (2) side. Since the mesh of the polyester resin is embedded and welded in the polypropylene resin having a lower melting temperature, it is possible to prevent the filter (40) from falling off from the ring (41) and peeling.
Such a filter ring (4) can be arranged as shown in FIGS. 6 and 7 and held between the header (5) and the tubular container body (2). For example, the outer peripheral surface (41b) of the ring (41) faces the inner peripheral surface (23a) of the inner cylindrical container main body protrusion (23), and the central axis (P) of the annular ring (41) on the header side. The annular flat surface (41c) that is perpendicular to the flat surface faces the annular flat surface (53) that is inside the header protrusion (52) and that is perpendicular to the central axis (P). ), the outer peripheral surface (55b) of the header protruding portion (55) protruding from the inside toward the ring (4) with a filter faces the inner peripheral surface (41a) of the ring, and the flat surface ( The substantially flat surface (41d) on the opposite side to 41c) is arranged so as to face the annular flat surface (25) perpendicular to the central axis (P) inside the inner cylindrical container main body protrusion. You can
これらの４つの対向箇所においては、２つの対向する面同士が近接し、面間に処理流体のデッドスペースが生じないようにすることが好ましいが、筒状容器本体（２）とヘッダー（５）の溶着時における組立てプロセスに支障を来すことがない程度の僅かな隙間は必要である。 At these four facing portions, it is preferable that the two facing surfaces are close to each other so that a dead space for the processing fluid does not occur between the facing surfaces. However, the tubular container body (2) and the header (5) It is necessary to have a small gap to the extent that it does not hinder the assembly process during welding.
また、前記したように、フィルター付きリング（４）のリング（４１）の内周面（４１ａ）は、ヘッダー突出部（５５）の外周面（５５ｂ）に接することで、筒状容器本体の内周面（２６）は、ヘッダー突出部（５５）の内面に沿って、環状ノズル（５０）の内面に繋がり、ビーズの隙間を通過した流体が、その流れが乱されずにフィルター（４０）を通過することが可能となる。 In addition, as described above, the inner peripheral surface (41a) of the ring (41) of the ring (4) with a filter contacts the outer peripheral surface (55b) of the header protrusion (55), so that The peripheral surface (26) is connected to the inner surface of the annular nozzle (50) along the inner surface of the header protrusion (55), and the fluid passing through the gap between the beads passes through the filter (40) without being disturbed. It is possible to pass.
［ヘッダー（５）、及び筒状容器本体（５）の材質］
筒状容器本体（２）及びヘッダー（５）は、同種の熱可塑性樹脂を、例えば、射出成形して製造されたものであることができる。尚、フィルター付きリング（４）のリング（４１）も同一素材であることができる。熱可塑性樹脂としては、特に制限はないが、例えば、結晶性樹脂として、エチレンとα−オレフィンとの共重合体、低密度ポリエチレン、高密度ポリエチレンなどのポリエチレン系樹脂、プロピレン単体の重合体、プロピレンとエチレンとの共重合体、プロピレンとエチレンと他のα―オレフィンとの共重合体などのポリプロピレン系樹脂が挙げられる。また、非晶性樹脂として、ポリエステル、ポリカーボネート、ポリスチレン、スチレン‐ブタジエン共重合体（ＳＢＳ）、アクリロニトリル−ブタジエン−スチレン共重合体（ＡＢＳ）等の樹脂が挙げられ、これらは単体で用いられてもよく、混合物であってもよい。本実施形態の筒状容器を構成する筒状容器本体（２）及びヘッダー（５）の材質としては、剛性、耐熱性、コスト、生体適合性、成形容易性、超音波溶着性等の観点から、ポリプロピレン系樹脂が好ましく、中でもプロピレンとエチレンのランダム共重合体が好ましく、エチレン含量が１〜８質量％に調整されたプロピレンとエチレンのランダム共重合体がより好ましい。
[Material of header (5) and tubular container body (5)]
The cylindrical container body (2) and the header (5) may be manufactured by injection molding the same kind of thermoplastic resin, for example. The ring (41) of the ring with filter (4) can be made of the same material. The thermoplastic resin is not particularly limited, but for example, as the crystalline resin, a copolymer of ethylene and α-olefin, a polyethylene resin such as low density polyethylene or high density polyethylene, a polymer of propylene simple substance, propylene. And polypropylene-based resins such as copolymers of ethylene with ethylene and copolymers of propylene with ethylene and other α-olefins. In addition, examples of the amorphous resin include resins such as polyester, polycarbonate, polystyrene, styrene-butadiene copolymer (SBS), and acrylonitrile-butadiene-styrene copolymer (ABS), which may be used alone. Well, it may be a mixture. From the viewpoint of rigidity, heat resistance, cost, biocompatibility, moldability, ultrasonic weldability, etc., the material of the cylindrical container body (2) and the header (5) that form the cylindrical container of this embodiment is A polypropylene resin is preferable, and a random copolymer of propylene and ethylene is preferable, and a random copolymer of propylene and ethylene having an ethylene content adjusted to 1 to 8% by mass is more preferable.
［ヘッダーと筒状容器本体の超音波溶着］
本実施形態の筒状容器は、図７に示すように、ヘッダー（５）と筒状容器本体（２）とを、フィルター付きリング（４）を保持しつつ、ヘッダーの径方向に広がる板状の天面部（５１）に超音波ホーン（１００）を押し当てる超音波溶着により、気密又は液密状態で、前記熱可塑性樹脂の溶融により溶着する工程を含む方法により製造することができる。超音波ホーン（１００）が、ヘッダー（５）を中心軸（Ｐ）方向の外側から筒状容器本体（２）側に押圧しながら、ヘッダー（５）に向けて超音波振動を発振すると、超音波溶着（電気エネルギーを機械的振動エネルギーに変換し、加圧を同時に加えることによって、溶着される２つのパーツの接合面に強力な摩擦熱を発生させ、プラスチックを溶融し、接合させる技術）により、ヘッダー突出部（５２）の外周面（５２ｂ）と筒状容器本体の外側突出部（２２）の内周面（２２ａ）との間、及び、ヘッダー突出部（５２）の内周面（５２ａ）と筒状容器本体の内側突出部（２３）の外周面（２３ｂ）との間の少なくとも２箇所で、周方向全体で、ヘッダー（５）と筒状容器本体（２）とが、フィルター付きリング（４）を保持しつつ、気密又は液密状態で該熱可塑性樹脂の溶融により溶着されることができる。
[Ultrasonic welding of header and tubular container body]
As shown in FIG. 7, the tubular container of the present embodiment has a header (5) and a tubular container main body (2) which are plate-shaped and expand in the radial direction of the header while holding a ring (4) with a filter. It can be manufactured by a method including a step of welding by melting the thermoplastic resin in an airtight or liquid-tight state by ultrasonic welding in which an ultrasonic horn (100) is pressed against the top surface portion (51) of the above. When the ultrasonic horn (100) oscillates ultrasonic vibration toward the header (5) while pressing the header (5) from the outside in the direction of the central axis (P) toward the cylindrical container body (2), By sonic welding (a technique that converts electrical energy into mechanical vibration energy and applies pressure at the same time to generate strong frictional heat at the joining surfaces of the two parts to be welded to melt and join the plastic) Between the outer peripheral surface (52b) of the header protruding portion (52) and the inner peripheral surface (22a) of the outer protruding portion (22) of the tubular container body, and the inner peripheral surface (52a) of the header protruding portion (52). ) And the outer peripheral surface (23b) of the inner protruding portion (23) of the tubular container body, the header (5) and the tubular container body (2) are provided with a filter in the entire circumferential direction. It can be welded by melting the thermoplastic resin in an airtight or liquid-tight state while holding the ring (4).
超音波ホーン（１００）が発振する超音波振動については、周波数、圧力、振幅、時間が重要である。例えば、周波数１５ｋＨｚ、２０ｋＨｚ、３０ｋＨｚ、４０ｋＨｚ、５０ｋＨｚ、７０ｋＨｚ、振幅２０〜１２５μｍ、圧力５０Ｎ〜３０００Ｎ、時間０．１〜１秒であるが、溶着するに足りるものであれば特に制限はないが、状況に応じて比較的低い周波数（例えば、一般的に周波数２０ｋＨｚ程度の超音波が利用される場合における１５ｋＨｚ程度の低周波数）の超音波振動としてもよく、この場合、超音波ホーン（１００）からより離れた位置にまで超音波振動が届きやすくなる。溶着をより強固にしたい場合、振幅、圧力、時間の一部又は全てを大きくすることができるが、超音波振動が強すぎて筒状容器本体（２）又はヘッダー（５）が損傷するおそれがある場合には、より高い周波数を採用してもよい。 Frequency, pressure, amplitude, and time are important for ultrasonic vibration generated by the ultrasonic horn (100). For example, the frequency is 15 kHz, 20 kHz, 30 kHz, 40 kHz, 50 kHz, 70 kHz, the amplitude is 20 to 125 μm, the pressure is 50 N to 3000 N, and the time is 0.1 to 1 second, but it is not particularly limited as long as it is sufficient for welding. Depending on the situation, it may be an ultrasonic vibration of a relatively low frequency (for example, a low frequency of about 15 kHz when ultrasonic waves with a frequency of about 20 kHz is generally used), and in this case, from the ultrasonic horn (100). Ultrasonic vibrations can reach even more distant positions. When it is desired to make the welding stronger, the amplitude, pressure, and part or all of the time can be increased, but there is a risk that the ultrasonic vibration is too strong and the cylindrical container body (2) or the header (5) is damaged. In some cases, higher frequencies may be employed.
前記したように、超音波溶着時には、ヘッダー（５）と筒状容器本体（２）とは、平坦面が向かい合うように当接されるため、溶着時におけるヘッダー（５）又は筒状容器本体（２）の変形が起こりにくい。また、同様の理由により、超音波溶着におけるヘッダー（５）が筒状容器本体（２）に向かって押し込まれていく速度は、極めて遅いか又はゼロであるため、溶着部での摩擦熱による溶融量が増加して接合強度が増し、ヘッダー突出部（５２）の外周面（５２ｂ）と筒状容器本体の外側突出部（２２）の内周面（２２ａ）との間、及び、ヘッダー突出部（５２）の内周面（５２ａ）と筒状容器本体の内側突出部（２３）の外周面（２３ｂ）との間の少なくとも２箇所で、周方向全体で、ヘッダー（５）と筒状容器本体（２）とが、両者の間にフィルター付きリング（４）を保持しつつ、確実な気密又は液密状態での溶着が可能となる。但し、溶着に必要なエネルギーが過大であると、超音波ホーン接触面に傷が発生したり、溶着機の出力不足によるオーバーロードが発生したり、摩擦熱が過剰となって炭化が生じたり、フィルター付きリング（４）におけるフィルター（４０）とリング（４１）との間の溶着を破損したりするおそれがあるため、溶着に必要なエネルギーは適切に調整する必要がある。
以上のヘッダー（５）と筒状容器本体（２）の超音波溶着は、自動化された製造装置を用いて実施することができる。
As described above, at the time of ultrasonic welding, the header (5) and the tubular container body (2) are brought into contact with each other so that their flat surfaces face each other. Therefore, the header (5) or the tubular container body ( The deformation of 2) does not easily occur. Further, for the same reason, the speed at which the header (5) is pushed toward the tubular container body (2) in ultrasonic welding is extremely slow or zero, so that melting due to frictional heat at the welded portion occurs. The amount is increased to increase the bonding strength, and between the outer peripheral surface (52b) of the header protruding portion (52) and the inner peripheral surface (22a) of the outer protruding portion (22) of the tubular container body, and the header protruding portion. At least two locations between the inner peripheral surface (52a) of (52) and the outer peripheral surface (23b) of the inner protruding portion (23) of the tubular container body, in the entire circumferential direction, the header (5) and the tubular container. The main body (2) and the main body (2) hold the ring (4) with the filter therebetween, and can perform reliable welding in an airtight or liquid-tight state. However, if the energy required for welding is excessive, scratches may occur on the contact surface of the ultrasonic horn, overload may occur due to insufficient output of the welding machine, or carbonization may occur due to excessive friction heat. Since the welding between the filter (40) and the ring (41) in the ring with filter (4) may be damaged, the energy required for welding needs to be adjusted appropriately.
The ultrasonic welding of the header (5) and the cylindrical container body (2) described above can be carried out using an automated manufacturing apparatus.
図８に、溶着箇所を示す。図中、Ａは、ヘッダー突出部（５２）の内周面（５２ａ）と筒状容器本体の内側突出部（２３）の外周面（２３ｂ）との間に形成された溶着部であり、Ｂは、ヘッダー突出部（５２）の外周面（５２ｂ）と筒状容器本体の外側突出部（２２）の内周面（２２ａ）との間に形成された溶着部である。本実施形態の筒状容器においては、少なくともＡとＢの２箇所に気密・液密である確実な溶着部が形成されている。図中、Ｃは、超音波エネルギーが過大である場合に、フィルター付きリング（４）のリング（４１）の外周面（４１ｂ）と筒状容器本体の内側突出部（２３）の内周面（２３ａ）との間に形成されうる溶着部である。また、図中、Ｄは、超音波エネルギーが過大である場合に、筒状容器本体の外側突出部（２２）の先端にある中心軸（Ｐ）に対して垂直な環状平坦面（２２ｃ）とヘッダー突出部（５２）の外側にある中心軸（Ｐ）に対して垂直な環状平坦面（５４）との間に形成されうる溶着部である。Ｃ、Ｄの溶着部は気密・液密を保証できるものではない。 FIG. 8 shows a welded portion. In the figure, A is a welded portion formed between the inner peripheral surface (52a) of the header protruding portion (52) and the outer peripheral surface (23b) of the inner protruding portion (23) of the tubular container body, and B Is a welded portion formed between the outer peripheral surface (52b) of the header protruding portion (52) and the inner peripheral surface (22a) of the outer protruding portion (22) of the tubular container body. In the tubular container of the present embodiment, reliable welded portions that are airtight and liquid-tight are formed at least at two points A and B. In the figure, C indicates the outer peripheral surface (41b) of the ring (41) of the ring (4) with a filter and the inner peripheral surface (21) of the inner protruding portion (23) of the tubular container body when the ultrasonic energy is excessive. 23a) is a welded portion that can be formed between the welded portion and the welded portion. Further, in the figure, D is an annular flat surface (22c) perpendicular to the central axis (P) at the tip of the outer protruding portion (22) of the cylindrical container body when the ultrasonic energy is excessive. It is a welded portion that can be formed between the annular flat surface (54) outside the header protrusion (52) and perpendicular to the central axis (P). The welded portions of C and D cannot guarantee airtightness and liquidtightness.
図９は、ヘッダー（５）と筒状容器本体（２）の溶着後の状態の側面断面のＸ線ＣＴ画像であり、そして図１０は、ヘッダー（５）と筒状容器本体（２）の溶着後の状態の径方向断面のＸ線ＣＴ画像である。図９と１０に示すように、本実施形態の筒状容器においては、少なくともＡとＢの２箇所に気密・液密である確実な溶着部が形成されていることが分かる。 FIG. 9 is an X-ray CT image of a side cross-section of the header (5) and the tubular container body (2) after welding, and FIG. 10 shows the header (5) and the tubular container body (2). It is an X-ray CT image of a radial cross section in a state after welding. As shown in FIGS. 9 and 10, it can be seen that, in the tubular container of the present embodiment, a reliable welded portion that is airtight and liquidtight is formed at least at two points A and B.
［ビーズの充填、モジュールの製造］
上記のようにして製造した筒状容器（１）の筒状容器本体（２）の側面にある充填口（２０）から、分散媒に分散された血液浄化処理用ビーズを注入し、ヘッダー（５）の流体出入口（５０）から、該分散媒を排出する工程、該流体出入口（５０）を仮封止した後、該充填口（２０）から封入液を注入し、該筒状容器本体（２）の内周面（２６）と該充填口（２０）の内壁とで画される空間に弾性体（３１）を詰めて、該筒状容器本体（２）の内周面（２６）を面一にした後に、該充填口（２０）をキャップ（３）で封止する工程、次いで、これを包装した後、ガンマ線で滅菌処理する工程を経ることで、例えば、血液浄化処理用ビーズが充填された血液浄化処理モジュールを製造することができる。上記封入液としては、特に制限はないが、生理食塩水であることができる。また、上記弾性体（３１）も、特に制限はないが、シリリコーンゴムであることができる。
このようなビーズの充填、モジュールの製造は、ヘッダー（５）と筒状容器本体（２）の超音波溶着と同様に、自動化された製造装置を用いて実施することができる。尚、筒状容器（１）に、分散媒に分散された血液浄化処理用ビーズを注入する前に、該筒状容器（１）の内面を生体適合性材料でコーティングしておいてもよく、滅菌処理の方法や、仮封止の手段に特に制限はない。
[Bead filling, module manufacturing]
The blood purification treatment beads dispersed in the dispersion medium are injected from the filling port (20) on the side surface of the cylindrical container body (2) of the cylindrical container (1) manufactured as described above, and the header (5 ) Of discharging the dispersion medium from the fluid inlet/outlet port (50 ), after temporarily sealing the fluid inlet/outlet port (50 ), the filled liquid is injected from the filling port (20 ), and the tubular container body (2) ) Is packed with an elastic body (31) in a space defined by the inner peripheral surface (26) of the container) and the inner wall of the filling port (20), and the inner peripheral surface (26) of the cylindrical container body (2) is covered with the surface. For example, the beads for blood purification treatment are filled by going through the step of sealing the filling port (20) with the cap (3) after being made into one, and then sterilizing with gamma rays after packaging this. It is possible to manufacture the blood purification processing module. The above-mentioned enclosed liquid is not particularly limited, but may be physiological saline. The elastic body (31) is also not particularly limited, but may be silicorn rubber.
Filling of such beads and manufacturing of the module can be carried out by using an automated manufacturing apparatus, similarly to the ultrasonic welding of the header (5) and the tubular container body (2). Incidentally, before injecting the blood purification treatment beads dispersed in the dispersion medium into the cylindrical container (1), the inner surface of the cylindrical container (1) may be coated with a biocompatible material, There are no particular restrictions on the method of sterilization or the means of temporary sealing.
以上、添付図面を参照しながら本発明の実施形態について説明したが、本発明はかかる実施形態に制限されず、特許請求の範囲に記載された技術思想の範疇における各種の変更例又は修正例も、当然に本発明の技術的範囲に属するものである。 The embodiments of the present invention have been described above with reference to the accompanying drawings. However, the present invention is not limited to the embodiments, and various changes or modifications within the scope of the technical idea described in the claims are also possible. Of course, it belongs to the technical scope of the present invention.
例えば、上記実施形態においては、ヘッダー（５）は、筒状容器本体（２）に向けて突出する中心軸（Ｐ）断面において略矩形状のヘッダー突出部（５２）を有し、かつ、筒状容器本体（２）は、ヘッダー突出部（５２）を受容し、これと嵌合する陥凹部を有し、陥凹部は、ヘッダー突出部（５２）の内側に配置される中心軸（Ｐ）断面において略矩形状の筒状容器本体突出部（２３）と外側に配置される中心軸（Ｐ）断面において略矩形状の容器本体突出部（２２）とで構成されるものに限定されているが、本発明は、筒状容器本体（２）は、ヘッダー（５）に向かって突出する中心軸（Ｐ）断面において略矩形状の筒状容器本体突出部を有し、かつ、ヘッダー（５）は、筒状容器本体突出部を受容し、これと嵌合する陥凹部を有するもの、すなわち、本実施形態と凹凸構造が逆転したものをも包含する。また、以上の実施形態においては、ヘッダー（５）の天面部（５１）に超音波ホーン（１００）を押し当て、ヘッダー（５）を筒状容器本体（２）側に動かして溶着しているが、逆に、筒状容器本体（２）をヘッダー（５）側に動かして溶着してもよい。
また、モジュールの用途は、血液などの液体処理に限られず、気体の処理であって構わない。
For example, in the above-described embodiment, the header (5) has the header protruding portion (52) having a substantially rectangular shape in the central axis (P) cross section protruding toward the cylindrical container body (2), and The container body (2) has a recess for receiving and fitting the header protrusion (52), and the recess has a central axis (P) arranged inside the header protrusion (52). It is limited to a container body projecting portion (23) having a substantially rectangular cross section and a container body projecting portion (22) having a substantially rectangular cross section in the central axis (P) arranged outside. However, according to the present invention, the tubular container body (2) has a tubular container body projecting portion that is substantially rectangular in the central axis (P) cross section that projects toward the header (5), and the header (5) ) Also includes a container having a recess for receiving the protruding portion of the cylindrical container main body and fitting with the protruding portion, that is, one having the concavo-convex structure reversed from that of the present embodiment. In the above embodiment, the ultrasonic horn (100) is pressed against the top surface portion (51) of the header (5), and the header (5) is moved to the tubular container body (2) side and welded. However, conversely, the tubular container body (2) may be moved to the header (5) side for welding.
Further, the application of the module is not limited to the treatment of liquid such as blood, but may be the treatment of gas.
本発明に係る流体処理用ビーズを収納するためのフィルター付き熱可塑性樹脂製筒状容器は、ヘッダーと筒状容器本体との接合において、ヘッダー又は筒状容器本体のいずれかに中心軸（Ｐ）断面において略矩形の突出部を設け、該突出部内周面の周方向全体及び外周面の周方向全体において（すなわち、少なくとも２箇所の領域）で気密又は液密状態で熱可塑性樹脂の溶融により溶着されており、かつ、適用する超音波エネルギーを制御して、例えば、過度なエネルギーによる超音波ホーン接触面への傷の発生や溶着機の出力不足によるオーバーロード発生を回避しつつ、容器内部に保持されるフィルターを破損せずに、例えば、ヘッダーと筒状容器本体との間の溶着時にフィルターが脱落し、剥がれてしまうということ回避しつつ、十分な密閉性を確保することができ、また、比較的高価なＯリングを用いず低コストであり、かつ、締め付け等の管理が不要であり、組み立てに手間がかからず、さらに組み立てを自動化することができる。よって、本発明は、血液透析、血液透析濾過、血液濾過、血漿分離などの体外循環式の血液浄化処理、腹水などの体腔液処理、血液製剤のウィルス除去・処理などにおいて、リン酸、凝集物、白血球などの好ましくない成分、すなわち、被除去成分を吸着・除去することができる粒状成形体（ビーズ）を充填した使い捨てモジュールの容器として好適に利用可能である。 A tubular container made of a thermoplastic resin with a filter for accommodating a bead for fluid treatment according to the present invention has a central axis (P) at either the header or the tubular container body at the joining of the header and the tubular container body. A protrusion having a substantially rectangular cross section is provided, and the thermoplastic resin is welded in an airtight or liquid-tight state in the entire circumferential direction of the inner circumferential surface of the projecting portion and the entire circumferential direction of the outer circumferential surface (that is, at least two regions). And, by controlling the applied ultrasonic energy, for example, while avoiding the occurrence of damage to the ultrasonic horn contact surface due to excessive energy and the occurrence of overload due to insufficient output of the welding machine, Without damaging the retained filter, for example, while avoiding that the filter falls off and peels off during welding between the header and the tubular container body, it is possible to ensure sufficient airtightness. The cost is low without using a comparatively expensive O-ring, the management such as tightening is unnecessary, the assembly is not troublesome, and the assembly can be further automated. Therefore, the present invention provides phosphoric acid and aggregates in hemodialysis, hemodiafiltration, extracorporeal circulation type blood purification such as hemofiltration, plasma separation, coelomic fluid treatment such as ascites, virus removal/treatment of blood products, etc. It can be suitably used as a container of a disposable module filled with a granular molded body (beads) capable of adsorbing and removing undesired components such as white blood cells, that is, components to be removed.
１ 流体処理用ビーズを収納するためのフィルター付き筒状容器
２ 筒状容器本体
２０ 流体処理用ビーズの充填口
２１ 径方向に広がる板状の天面部
２２ 天面部２１の外周縁からヘッダー５側に向けて突出する筒状容器本体突出部（外側）
２２ａ 筒状容器本体突出部（外側）２２の内周面
２２ｃ 筒状容器本体突出部（外側）２２の先端にある中心軸Ｐに対して垂直の環状の平坦面
２３ 天面部２１のヘッダー５側に向けて突出する筒状容器本体突出部（内側）
２３ａ 筒状容器本体突出部（内側）２３の内周面
２３ｂ 筒状容器本体突出部（内側）２３の外周面
２３ｃ 筒状容器本体突出部（内側）２３の先端にある中心軸Ｐに対して垂直の環状の平坦面
２４ 中心軸Ｐに対して垂直の環状の平坦面（筒状容器本体突出部（外側）２２と筒状容器本体突出部（内側）２３の間）
２５ 中心軸Ｐに対して垂直の環状の平坦面（筒状容器本体突出部（内側）の内側）
２６ 筒状容器本体２の内周面
３ 流体処理用ビーズの充填口２０の封止キャップ
３１ 弾性体
４ フィルター付きリング
４０ フィルター
４１ フィルター４０の外周縁に接合されたリング
４１ａ リング４１の内周面
４１ｂ リング４１の外周面
４１ｃ リング４１の先端にある中心軸Ｐに対して垂直の環状の平坦面
４１ｄ 平坦面４１ｃの反対側（フィルター側）の略平坦面
５ ヘッダー
５０ 流体出入口（管状ノズル）
５１ 径方向に広がる板状の天面部
５２ 天面部５１の外周縁付近から筒状容器本体２側に向けて突出するヘッダー突出部
５２ａ ヘッダー突出部５２の内周面
５２ｂ ヘッダー突出部５２の外周面
５２ｃ ヘッダー突出部５２の先端にある中心軸Ｐに対して垂直の環状の平坦面
５３ 中心軸Ｐに対して垂直の環状の平坦面（ヘッダー突出部５２の内側）
５４ 中心軸Ｐに対して垂直の環状の平坦面（ヘッダー突出部５２の外側）
５５ 平坦面５３の内側からフィルター付きリング４側に向けて突出するヘッダー突出部
５５ｂ ヘッダー突出部５５の外周面
１００ 超音波ホーン
Ａ 溶着部（２３ｂと５２ａの間）
Ｂ 溶着部（２２ａと５２ｂの間）
Ｃ 溶着部（２３ａと４１ｂの間）
Ｄ 溶着部（２２ｃと５４の間）
1 Cylindrical container with a filter for accommodating beads for fluid treatment 2 Cylindrical container body 20 Filling port for beads for fluid treatment 21 Plate-shaped top surface portion 22 that extends in the radial direction 22 From the outer peripheral edge of the top surface portion 21 to the header 5 side Cylindrical container body protruding part (outside) protruding toward
22a Inner peripheral surface of cylindrical container main body protruding portion (outer side) 22 22c Annular flat surface perpendicular to central axis P at tip of cylindrical container main body protruding portion (outer side) 22 23 Header 5 side of top surface portion 21 Cylindrical container body protrusion (inside) protruding toward
23a Inner peripheral surface of cylindrical container body protruding portion (inner side) 23b Outer peripheral surface of cylindrical container body protruding portion (inner side) 23c With respect to central axis P at tip of cylindrical container body protruding portion (inner side) 23 Vertical annular flat surface 24: Vertical annular flat surface perpendicular to the central axis P (between the cylindrical container body protrusion (outside) 22 and the cylindrical container body protrusion (inside) 23)
25 An annular flat surface perpendicular to the central axis P (inside the tubular container body protrusion (inside))
26 Inner Circumferential Surface of Cylindrical Container Main Body 3 Sealing Cap for Filling Port 20 of Fluid Processing Bead 31 Elastic Body 4 Filter Ring 40 Filter 41 Ring Joined to Outer Edge of Filter 40 41a Inner Circumferential Surface of Ring 41 41b an outer peripheral surface of the ring 41 c an annular flat surface perpendicular to the central axis P at the tip of the ring 41 41d a substantially flat surface opposite to the flat surface 41c (filter side) 5 header 50 fluid inlet/outlet (tubular nozzle)
51 a plate-shaped top surface portion that spreads in the radial direction 52 a header projection portion 52a that projects from the vicinity of the outer peripheral edge of the top surface portion 51 toward the cylindrical container body 2 side 52a an inner peripheral surface of the header projection portion 52b an outer peripheral surface of the header projection portion 52 52c annular flat surface perpendicular to the central axis P at the tip of the header protruding portion 52 53 annular flat surface perpendicular to the central axis P (inside the header protruding portion 52)
54 An annular flat surface perpendicular to the central axis P (outside the header protrusion 52)
55 Header protrusion 55b protruding from the inside of the flat surface 53 toward the ring with filter 55b Outer peripheral surface of the header protrusion 55 100 Ultrasonic horn A Welding portion (between 23b and 52a)
B welding part (between 22a and 52b)
C welding part (between 23a and 41b)
D weld (between 22c and 54)
Claims (9)
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| JP2018241841A JP7402607B2 (en) | 2018-12-25 | 2018-12-25 | Filtered cylindrical container for housing beads for fluid processing |
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| JP7402607B2 JP7402607B2 (en) | 2023-12-21 |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1142709A (en) * | 1997-05-26 | 1999-02-16 | Kojima Press Co Ltd | Manufacture of resin-molded item having inner member |
| JP2001219062A (en) * | 1999-12-02 | 2001-08-14 | Kanegafuchi Chem Ind Co Ltd | Peptidoglycan adsorbing material, and method and device for adsorbing/removing peptidoglycan |
| JP2008104843A (en) * | 2006-09-26 | 2008-05-08 | Toray Ind Inc | Cylindrical lid material and module using the same |
| JP2008238437A (en) * | 2007-03-26 | 2008-10-09 | Toray Ind Inc | Method for manufacturing container |
| JP2011224142A (en) * | 2010-04-20 | 2011-11-10 | Nikkiso Co Ltd | Bead-like adsorbent, and blood purifier using the same |
| JP2018058033A (en) * | 2016-10-05 | 2018-04-12 | 旭化成メディカル株式会社 | Hollow fiber membrane module and manufacturing method of hollow fiber membrane module |
-
2018
- 2018-12-25 JP JP2018241841A patent/JP7402607B2/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH1142709A (en) * | 1997-05-26 | 1999-02-16 | Kojima Press Co Ltd | Manufacture of resin-molded item having inner member |
| JP2001219062A (en) * | 1999-12-02 | 2001-08-14 | Kanegafuchi Chem Ind Co Ltd | Peptidoglycan adsorbing material, and method and device for adsorbing/removing peptidoglycan |
| JP2008104843A (en) * | 2006-09-26 | 2008-05-08 | Toray Ind Inc | Cylindrical lid material and module using the same |
| JP2008238437A (en) * | 2007-03-26 | 2008-10-09 | Toray Ind Inc | Method for manufacturing container |
| JP2011224142A (en) * | 2010-04-20 | 2011-11-10 | Nikkiso Co Ltd | Bead-like adsorbent, and blood purifier using the same |
| JP2018058033A (en) * | 2016-10-05 | 2018-04-12 | 旭化成メディカル株式会社 | Hollow fiber membrane module and manufacturing method of hollow fiber membrane module |
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