JP2020099234A - Liquid milk prepared for infant, method for producing the same, and packed liquid milk - Google Patents
Liquid milk prepared for infant, method for producing the same, and packed liquid milk Download PDFInfo
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- 239000007788 liquid Substances 0.000 title claims abstract description 80
- 235000013336 milk Nutrition 0.000 title claims abstract description 77
- 210000004080 milk Anatomy 0.000 title claims abstract description 77
- 239000008267 milk Substances 0.000 title claims abstract description 76
- 238000004519 manufacturing process Methods 0.000 title claims description 7
- AXCZMVOFGPJBDE-UHFFFAOYSA-L calcium dihydroxide Chemical compound [OH-].[OH-].[Ca+2] AXCZMVOFGPJBDE-UHFFFAOYSA-L 0.000 claims abstract description 14
- 239000000920 calcium hydroxide Substances 0.000 claims abstract description 14
- 229910001861 calcium hydroxide Inorganic materials 0.000 claims abstract description 14
- 235000013350 formula milk Nutrition 0.000 claims description 44
- 235000013305 food Nutrition 0.000 abstract description 7
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 235000004252 protein component Nutrition 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 description 20
- 238000004659 sterilization and disinfection Methods 0.000 description 19
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 17
- 239000011575 calcium Substances 0.000 description 17
- 229910052791 calcium Inorganic materials 0.000 description 17
- 235000001465 calcium Nutrition 0.000 description 17
- 238000001556 precipitation Methods 0.000 description 15
- 235000018102 proteins Nutrition 0.000 description 15
- 102000004169 proteins and genes Human genes 0.000 description 15
- 108090000623 proteins and genes Proteins 0.000 description 15
- 238000003860 storage Methods 0.000 description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 9
- 239000000843 powder Substances 0.000 description 8
- 238000002156 mixing Methods 0.000 description 7
- 239000002994 raw material Substances 0.000 description 7
- 239000004615 ingredient Substances 0.000 description 6
- 238000013329 compounding Methods 0.000 description 5
- 238000011156 evaluation Methods 0.000 description 5
- 239000000203 mixture Substances 0.000 description 5
- 239000005862 Whey Substances 0.000 description 4
- 102000007544 Whey Proteins Human genes 0.000 description 4
- 108010046377 Whey Proteins Proteins 0.000 description 4
- 235000013365 dairy product Nutrition 0.000 description 4
- 239000003995 emulsifying agent Substances 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 230000007774 longterm Effects 0.000 description 4
- 238000010979 pH adjustment Methods 0.000 description 4
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
- 238000002360 preparation method Methods 0.000 description 4
- 102000014171 Milk Proteins Human genes 0.000 description 3
- 108010011756 Milk Proteins Proteins 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- -1 electricity Substances 0.000 description 3
- 239000003349 gelling agent Substances 0.000 description 3
- 238000002372 labelling Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 235000021239 milk protein Nutrition 0.000 description 3
- 239000004033 plastic Substances 0.000 description 3
- 235000008476 powdered milk Nutrition 0.000 description 3
- 230000006920 protein precipitation Effects 0.000 description 3
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- 238000004090 dissolution Methods 0.000 description 2
- 235000020256 human milk Nutrition 0.000 description 2
- 210000004251 human milk Anatomy 0.000 description 2
- 235000020124 milk-based beverage Nutrition 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- 229910000027 potassium carbonate Inorganic materials 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 235000020183 skimmed milk Nutrition 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- 238000012371 Aseptic Filling Methods 0.000 description 1
- BHPQYMZQTOCNFJ-UHFFFAOYSA-N Calcium cation Chemical compound [Ca+2] BHPQYMZQTOCNFJ-UHFFFAOYSA-N 0.000 description 1
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 1
- 206010014418 Electrolyte imbalance Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 238000010793 Steam injection (oil industry) Methods 0.000 description 1
- 229930003268 Vitamin C Natural products 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000011449 brick Substances 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- 229910001424 calcium ion Inorganic materials 0.000 description 1
- BRPQOXSCLDDYGP-UHFFFAOYSA-N calcium oxide Chemical compound [O-2].[Ca+2] BRPQOXSCLDDYGP-UHFFFAOYSA-N 0.000 description 1
- 239000000292 calcium oxide Substances 0.000 description 1
- ODINCKMPIJJUCX-UHFFFAOYSA-N calcium oxide Inorganic materials [Ca]=O ODINCKMPIJJUCX-UHFFFAOYSA-N 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 235000013373 food additive Nutrition 0.000 description 1
- 239000002778 food additive Substances 0.000 description 1
- 235000012041 food component Nutrition 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000006651 lactation Effects 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 238000011068 loading method Methods 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000004845 protein aggregation Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/38—Other non-alcoholic beverages
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23C—DAIRY PRODUCTS, e.g. MILK, BUTTER OR CHEESE; MILK OR CHEESE SUBSTITUTES; MAKING THEREOF
- A23C9/00—Milk preparations; Milk powder or milk powder preparations
- A23C9/152—Milk preparations; Milk powder or milk powder preparations containing additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/66—Proteins
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Health & Medical Sciences (AREA)
- Nutrition Science (AREA)
- Dairy Products (AREA)
- Non-Alcoholic Beverages (AREA)
Abstract
Description
本発明は、乳児用調製液状乳及びその製造方法並びに容器詰液状乳に関する。 The present invention relates to infant formula liquid milk, a method for producing the same, and container-packaged liquid milk.
女性の社会進出に伴い共働き世帯が年々増加しており、父親や祖父母が育児に関わる機会が増加している。 The number of dual-income households is increasing year by year as women advance into society, and the opportunities for fathers and grandparents to participate in childcare are increasing.
授乳期には、母乳、粉ミルク、両者混合の３通りの栄養方法が主体であるが、
その他の選択肢として乳児用の液体ミルクがある。液体ミルクは哺乳瓶に移し替えてそのまま与えられるので時間がかからず、夜間や外出時などで特に便利かつ衛生的であり、保育者の体調不良のときなどに有用である。また、常温で長期間保存できるだけでなく、水や電気、ガス等の燃料を使わずに授乳できることから災害時の利用も期待されている。
During the lactation period, there are three main nutrition methods: breast milk, powdered milk, and a mixture of both.
Another option is liquid milk for infants. Since liquid milk is transferred to a baby bottle and given as it is, it does not take much time, and it is particularly convenient and hygienic at night or when going out, and is useful when a child-care worker feels unwell. Moreover, not only can it be stored at room temperature for a long period of time, but it can be fed without using fuel such as water, electricity, gas, etc., so it is expected to be used in the event of a disaster.
乳児用液体ミルクは粉ミルクと同様に、国内においては「乳及び乳製品の成分規格等に関する省令」、「特別用途食品 乳児用調製乳たる表示の許可基準」として、国際的には「STANDARD FOR INFANT FORMULA AND FORMULAS FOR SPECIAL MEDICAL PURPOSES INTENDED FOR INFANTS CODEX STAN 72-1981」により製造方法や規格が定められており、乳幼児の成長に必要な十分量のたんぱく質及びカルシウムを賞味期間中担保する必要がある。長期保存時におけるたんぱく質、カルシウムの沈殿は、摂取すべき栄養成分が不足するリスクにつながるため、できるだけ抑える必要がある。 Liquid milk for infants is the same as powdered milk in Japan, as “Ministerial Ordinance on Standards of Ingredients for Milk and Dairy Products” and “Standard for Permitting Labeling of Special-purpose Food Infant Formulas” as international standard “STANDARD FOR INFANT”. FORMULA AND FORMULAS FOR SPECIAL MEDICAL PURPOSES INTENDED FOR INFANTS CODEX STAN 72-1981” defines the manufacturing method and standards, and it is necessary to secure a sufficient amount of protein and calcium necessary for the growth of infants during the best season. Precipitation of protein and calcium during long-term storage leads to the risk of deficiency of nutrients to be ingested, so it should be suppressed as much as possible.
乳たんぱく質を含む乳飲料の沈殿抑制に関し、特許文献１はゲル化剤を使用することによるカルシウム粒子の分散性向上について記載している。 Regarding suppression of precipitation of a milk drink containing milk protein, Patent Document 1 describes improvement of dispersibility of calcium particles by using a gelling agent.
特許文献２〜３は、粉ミルクの製造時にｐＨ調整の目的で水酸化カルシウムを使用することを開示している。 Patent Documents 2 to 3 disclose that calcium hydroxide is used for the purpose of adjusting the pH during the production of powdered milk.
不溶性カルシウムが沈殿を引き起こすことは言うまでもないが、カルシウム製剤由来の二価のカルシウムイオンはたんぱく質と反応しやすく、過剰に添加すると、殺菌時のたんぱく凝集や沈殿を引き起こすリスクもある。そのため、カルシウム製剤を配合することによるｐＨ調整は、乳飲料では適切ではない方法とされてきた。（特許文献４）
一方、特別用途食品である乳児用調製液状乳においては、使用できる添加物に制限があり、従来技術のようにセルロース製剤やゲル化剤などの食品添加物による沈殿抑制の選択は困難である。乳製品においては中性付近にｐＨを調整することで、乳たんぱく質の殺菌時や保存下の安定性が向上することは知られているが、たんぱく質・カリウム・ナトリウムが乳児の腎臓に負担をかけることから、カリウム塩・ナトリウム塩を配合することによるｐＨ調整には限界があった。そのため、従来技術を用いて長期間保存する場合、沈殿を抑制することができなかった。
It goes without saying that insoluble calcium causes precipitation, but divalent calcium ions derived from calcium preparations easily react with proteins, and if added in excess, there is a risk of causing protein aggregation and precipitation during sterilization. Therefore, the pH adjustment by adding a calcium preparation has been regarded as an unsuitable method for milk drinks. (Patent Document 4)
On the other hand, in infant formula liquid milk, which is a special-purpose food, the additives that can be used are limited, and it is difficult to select precipitation suppression by food additives such as a cellulose preparation and a gelling agent as in the prior art. In dairy products, it is known that adjusting the pH to around neutrality improves the stability of milk proteins during sterilization and storage, but proteins, potassium, and sodium impose a burden on the kidneys of infants. Therefore, there is a limit to the pH adjustment by blending the potassium salt/sodium salt. Therefore, when it preserve|saved for a long time using the prior art, precipitation could not be suppressed.
本発明は、長期保存する特別用途食品の乳児用調製液状乳におけるカルシウムとたんぱく質の沈殿抑制を目的とする。 The present invention aims at suppressing the precipitation of calcium and protein in liquid infant formula for special purpose foods that are stored for a long period of time.
本発明は、以下の乳児用調製液状乳及びその製造方法並びに容器詰液状乳を提供するものである。
項１． 水酸化カルシウムを含み、ｐＨが６．９〜７．３であることを特徴とする乳児用調製液状乳。
項２． ｐＨが７．０〜７．２である、項１に記載の乳児用調製液状乳。
項３． 乳児用調製液状乳１００ｇ当たり水酸化カルシウムを7.5〜18ｍｇ含む、項１又は２に記載の乳児用調製液状乳。
項４． 腎溶質負荷が15mOsm以下である、項１〜３のいずれか１項に記載の乳児用調製液状乳。
項５． 項１〜４のいずれか１項に記載の乳児用調製液状乳を含む、容器詰液状乳。
項６． 容器が紙パックである、項５に記載の容器詰液状乳。
項７． 水酸化カルシウムを添加する工程、及び、ｐＨを６．９〜７．３に調整する工程を含むことを特徴とする項１に記載の乳児用調製液状乳の製造方法。
The present invention provides the following infant formula liquid milk, a method for producing the same, and container-packaged liquid milk.
Item 1. A liquid infant formula for infants, which contains calcium hydroxide and has a pH of 6.9 to 7.3.
Item 2. Item 2. The infant formula liquid milk according to Item 1, having a pH of 7.0 to 7.2.
Item 3. Item 3. The infant formula liquid milk according to Item 1 or 2, which contains 7.5 to 18 mg of calcium hydroxide per 100 g of infant formula liquid milk.
Item 4. Item 4. The infant formula liquid milk according to any one of Items 1 to 3, which has a renal solute load of 15 mOsm or less.
Item 5. Item 10. A container-packed liquid milk containing the infant formula liquid milk according to any one of items 1 to 4.
Item 6. Item 6. The packaged liquid milk according to Item 5, wherein the container is a paper pack.
Item 7. Item 2. The method for producing infant formula liquid milk according to Item 1, comprising a step of adding calcium hydroxide and a step of adjusting the pH to 6.9 to 7.3.
たんぱく質とカルシウムの沈殿を抑制することができただけでなく、乳幼児向けの栄養設計において重要な基準となっている腎溶質負荷が15mOsmを超えない範囲でｐＨを調整できた。 Not only was it able to suppress the precipitation of proteins and calcium, but it was also possible to adjust the pH within the range where the renal solute load, which is an important criterion in nutritional design for infants, does not exceed 15 mOsm.
本明細書において、乳児用調製液状乳は特別用途食品に該当し、その成分及び配合量は従来から市販されている乳児用調製粉乳と同じ成分組成を有する。具体的には、乳児用調製液状乳は「乳及び乳製品の成分規格等に関する省令」の「別添１ 特別用途食品の表示許可基準」の「第４ 乳児用調製乳たる表示の許可基準」において表２に示す成分組成の基準に適合したものであることが定められており、本発明の乳児用調製液状乳もこの基準に適合するものである。例えば、本発明の乳児用調製液状乳は、100kcal当たりの組成として、たんぱく質を1.8〜3.0ｇ含み、カルシウムを50〜140 mg含む。 In the present specification, the infant formula liquid milk corresponds to a special-purpose food, and the components and blending amounts thereof have the same component composition as that of the infant formula powder commercially available in the past. Specifically, the liquid infant formula for infants is defined in "Ministerial Ordinance Concerning Ingredient Standards for Milk and Dairy Products," "Appendix 1 Standards for Permitting Labeling of Special Purpose Foods," "4th Permitting Standard for Labeling Baby Infant Formulas." It is defined in the above that the compositional standard shown in Table 2 is satisfied, and the infant formula liquid milk of the present invention also complies with this standard. For example, the liquid infant formula of the present invention contains 1.8 to 3.0 g of protein and 50 to 140 mg of calcium per 100 kcal.
乳児用調製粉乳は、粉末の形態で販売され、温水に溶解された直後に使用されるために沈殿の問題は生じないが、本発明の乳児用調製液状乳は液状であり、賞味期限（例えば６ヶ月から１年程度）の期間、沈殿の生成をできるだけ抑制する必要がある。一方、乳児用調製液状乳は、成分組成が厳密に定められており、使用できる添加物にも制約がある。セルロース製剤やゲル化剤等の沈殿防止効果のある成分はCODEXで定められた調製液状乳に使用可能な添加物リストに掲載されておらず、使用できない。 The infant formula is sold in the form of a powder, and since it is used immediately after being dissolved in warm water, it does not cause a problem of precipitation.However, the infant formula liquid milk of the present invention is a liquid and has a shelf life (for example, For 6 months to 1 year), it is necessary to suppress the generation of precipitates as much as possible. On the other hand, the composition of the infant formula liquid milk is strictly defined, and there are restrictions on the additives that can be used. Ingredients that have the effect of preventing precipitation, such as cellulose preparations and gelling agents, cannot be used because they are not listed in the list of additives that can be used in prepared liquid milk specified by CODEX.
本発明の乳児用調製液状乳のｐＨは、好ましくは６．９〜７．３程度、より好ましくは７．０〜７．２程度である。ｐＨが上記の好ましい範囲にあれば、長期保存時のたんぱく質を含む沈殿が抑制される。ｐＨは、殺菌方法や配合によって±０．１、或いは±０．２程度殺菌前後で変化することがあるので、殺菌後のｐＨが６．９〜７．３の範囲に入るように殺菌前のｐＨを調整するのがよい。 The pH of the liquid infant formula of the present invention is preferably about 6.9 to 7.3, and more preferably about 7.0 to 7.2. When the pH is within the above preferred range, precipitation containing proteins during long-term storage is suppressed. The pH may change before and after sterilization by about ±0.1 or ±0.2 depending on the sterilization method and composition, so that the pH before sterilization should be adjusted so that the pH after sterilization falls within the range of 6.9 to 7.3. It is better to adjust the pH.
本発明の乳児用調製液状乳は、水酸化カルシウムの添加とｐＨ調整によって、長期保存時の沈殿生成が抑制される。水酸化カルシウムの添加量は0.0075〜0.018質量％程度（乳児用調製液状乳１００ｇ当たり水酸化カルシウムを7.5〜18 mg程度に対応）、より好ましくは0.008〜0.013質量％程度（乳児用調製液状乳１００ｇ当たり水酸化カルシウムを8〜13 mg程度に対応）の範囲とすることが、沈殿抑制に好ましい。水酸化カルシウムは沈殿抑制とｐＨ調整の機能を兼ねることができる。 In the infant formula liquid milk of the present invention, the addition of calcium hydroxide and the pH adjustment suppress the formation of precipitates during long-term storage. The amount of calcium hydroxide added is about 0.0075 to 0.018% by mass (corresponding to about 7.5 to 18 mg of calcium hydroxide per 100 g of infant formula liquid milk), more preferably about 0.008 to 0.013% by mass (100 g infant formula liquid milk). It is preferable to control the precipitation by setting the amount of calcium hydroxide per 8 to 13 mg). Calcium hydroxide can have the functions of suppressing precipitation and adjusting pH.
乳児用調製液状乳には、脱塩ホエイパウダー、たんぱく質濃縮ホエイパウダー、脱脂粉乳などの乳たんぱく質を含む１種以上の原料が配合されるが、これらの乳由来の原料はカルシウムも含むので、水酸化カルシウムの配合量は、乳児用調製液状乳のカルシウム濃度が「乳及び乳製品の成分規格等に関する省令」の基準を満たすようにする必要がある。 Infant-prepared liquid milk is blended with one or more raw materials containing milk proteins such as desalted whey powder, protein-enriched whey powder, skim milk powder, etc. The amount of calcium oxide to be blended must be such that the calcium concentration of the infant formula liquid milk meets the criteria of "Ministerial Ordinance on Standards of Ingredients of Milk and Milk Products".
本発明の乳児用調製液状乳は、６ヶ月〜１年程度の保存期間後の沈殿量が、100gあたり1g以下であり、この程度の沈殿量であれば、特別用途食品 乳児用調製乳たる表示の許可基準に定められた栄養成分の規格基準に影響しないことから、乳児用調製液状乳として許容される。 The liquid infant formula of the present invention has a precipitation amount of 1 g or less per 100 g after a storage period of about 6 months to 1 year, and if the precipitation amount is about this amount, it is indicated as a special-purpose food infant formula. Since it does not affect the standard of the nutritional components specified in the permit standard, it is acceptable as infant formula liquid milk.
本発明の乳児用調製液状乳は、たんぱく質を1.1〜2.1質量％程度、より好ましくは1.2〜1.5質量％程度含む。乳児用液体ミルクにおいては、できるかぎり母乳に近づけることが求められることから、たんぱく質の濃度は定められた範囲内で低いほうがよい。 The infant formula liquid milk of the present invention contains protein in an amount of about 1.1 to 2.1% by mass, more preferably about 1.2 to 1.5% by mass. Since liquid milk for infants is required to be as close to breast milk as possible, the protein concentration should be as low as possible within the prescribed range.
本発明の乳児用調製液状乳は、カルシウムを0.030〜0.098質量％程度、より好ましくは0.032〜0.060質量％程度含む。 The infant formula liquid milk of the present invention contains about 0.030 to 0.098% by mass of calcium, and more preferably about 0.032 to 0.060% by mass.
本発明の乳児用調製液状乳は、乳原料（例えば、脱塩ホエイパウダー、脱脂粉乳、たんぱく質濃縮ホエイパウダーなど）、乳化剤（レシチンなど）、油脂類（調合油など）、ビタミン・ミネラル類、カルシウム強化剤（炭酸カルシウム、クエン酸カルシウムなど）、ｐＨ調整剤（炭酸カリウム、炭酸水素ナトリウムなど）及び水酸化カルシウムを「乳及び乳製品の成分規格等に関する省令」に規定される成分組成に合うように水（温水）に溶解させ、容器詰前又は後に殺菌処理を行うことによって、もしくは無菌充填によって製造することができる。この液状乳の濃度は、１００ｍＬ当たり６０〜７０ｋｃａｌ程度になるように溶解すればよい。乳化剤としては、CODEX のポジティブリスト（例えば、STANDARD FOR INFANT FORMULA AND FORMULAS FOR SPECIAL MEDICAL PURPOSES INTENDED FOR INFANTS CODEX STAN 72-1981 4.2 Emulsifiers）に記載されたものであれば、いずれも選択可能である。長期保存下で減衰する水溶性ビタミン類については、賞味期間満了まで担保できるよう設計される必要がある。特に減衰の著しいビタミンCについては、30〜70mg/100kcalの範囲で設計されることが望ましい。 The infant formula liquid milk of the present invention includes milk raw materials (for example, desalted whey powder, skim milk powder, protein-concentrated whey powder, etc.), emulsifiers (lecithin, etc.), oils and fats (prepared oil, etc.), vitamins and minerals, calcium. Enhancer (calcium carbonate, calcium citrate, etc.), pH adjuster (potassium carbonate, sodium hydrogencarbonate, etc.) and calcium hydroxide to meet the composition of ingredients specified in "Ministerial Ordinance Concerning Ingredient Standards for Milk and Dairy Products" It can be produced by dissolving it in water (warm water) and sterilizing it before or after container filling, or by aseptic filling. The liquid milk may be dissolved so that the concentration of the liquid milk is about 60 to 70 kcal per 100 mL. As the emulsifier, any emulsifier can be selected as long as it is described in the CODEX positive list (for example, STANDARD FOR INFANT FORMULA AND FORMULAS FOR SPECIAL MEDICAL PURPOSES INTENDED FOR INFANTS CODEX STAN 72-1981 4.2 Emulsifiers). Water-soluble vitamins that decay during long-term storage need to be designed so that they can be guaranteed until the expiry date. Especially for vitamin C, which has a marked attenuation, it is desirable to design in the range of 30 to 70 mg/100 kcal.
上記液状乳を充填する容器としては、紙パック、瓶、缶、レトルトパウチなどが挙げられ、紙パックが好ましい。殺菌は、液状乳中で生育できる微生物が全て殺菌されている状態が好ましく、そのような殺菌条件としては、110〜150℃で0.5秒間〜100分間、より好ましくは121℃〜150℃で0.5秒間〜8分、さらに好ましくは140〜150℃で0.5秒間〜5秒間の条件が挙げられる。殺菌は、容器の充填前に行い、無菌充填してもよく、液状乳を容器に充填後に殺菌処理してもよい。 Examples of the container for filling the liquid milk include a paper pack, a bottle, a can, a retort pouch, and the like, and a paper pack is preferable. Sterilization is preferably a state in which all microorganisms that can grow in liquid milk are sterilized, and such sterilization conditions include 110 to 150°C for 0.5 seconds to 100 minutes, and more preferably 121°C to 150°C for 0.5 seconds. The conditions include -8 minutes, more preferably 140-150°C and 0.5 seconds-5 seconds. The sterilization may be performed before filling the container, and may be aseptically filled, or the liquid milk may be sterilized after filling the container.
本発明の容器詰液状乳は、常温保存が可能である。 The packaged liquid milk of the present invention can be stored at room temperature.
本発明の乳児用調製液状乳の腎溶質負荷は、好ましくは15 mOsm/100ml以下である。腎溶質負荷が15mOsm/100mlを超えない範囲であれば、他のpH調整の使用は可能である。ただし、新生児に対する不適当なナトリウム負荷は電解質異常や浮腫を生じる危険性があるため、他のpH調整剤を使用する場合、炭酸カリウムなどのカリウム塩によるpH調整が好ましい。 The renal solute load of the infant formula liquid milk of the present invention is preferably 15 mOsm/100 ml or less. Other pH adjustments are possible as long as the renal solute load does not exceed 15 mOsm/100 ml. However, improper sodium loading on newborns may cause electrolyte abnormalities and edema, so when other pH adjusting agents are used, it is preferable to adjust the pH with a potassium salt such as potassium carbonate.
以下、本発明について実施例を用いて具体的に説明するが、本発明はこれらに限定されるものではない。
＜腎溶出負荷の計算方法＞
実施例及び比較例で得られた液状乳の腎溶出負荷は、以下のように算出した。
腎溶質負荷(mOsm/100ml)
＝たんぱく質(mg/100ml)/(6.25*14*2)+2(Na+K)(mEq/100ml)
Hereinafter, the present invention will be specifically described with reference to examples, but the present invention is not limited thereto.
<Calculation method of renal dissolution load>
The renal dissolution load of the liquid milk obtained in Examples and Comparative Examples was calculated as follows.
Renal solute load (mOsm/100ml)
= Protein (mg/100ml)/(6.25*14*2)+2(Na+K)(mEq/100ml)
[実施例1]
下記の表１に示す各成分を、表１に示す配合量で作製した。液状乳の殺菌前のpHは7.1、殺菌後のpHは7.0であった。また、このときのたんぱく質量は1.45g/100g、カルシウム総量は41mg/100g、腎溶質負荷は14.8 mOsm/100ml、であった。
0〜70℃の水に全原料を混合して液状乳を調製し、液状乳を、均質化（均質加圧25MPa）・殺菌し（プレート殺菌機で140℃60秒間）、保存評価用の500mlプラスチック容器に充填し、本発明の容器詰液状乳を得た。
[Example 1]
Each component shown in the following Table 1 was prepared with the compounding amount shown in Table 1. The pH of the liquid milk before sterilization was 7.1 and the pH after sterilization was 7.0. At this time, the protein mass was 1.45 g/100 g, the total calcium amount was 41 mg/100 g, and the renal solute load was 14.8 mOsm/100 ml.
Liquid milk is prepared by mixing all raw materials with water at 0-70°C, and the liquid milk is homogenized (homogeneous pressure 25MPa) and sterilized (140°C for 60 seconds with a plate sterilizer), and 500 ml for storage evaluation. It was filled in a plastic container to obtain the packaged liquid milk of the present invention.
なお、表１〜表５中の数値は質量％である。 The numerical values in Tables 1 to 5 are% by mass.
[比較例1]
下記の表2に示す各成分を、表2に示す配合量で作製した。液状乳の殺菌前のpHは6.9、殺菌後のpHは6.8であった。また、このときのたんぱく質量は1.45g/100g、カルシウム総量は41mg/100g、腎溶質負荷は14.8 mOsm/100ml、であった。
0〜70℃の水に全原料を混合して液状乳を調製し、液状乳を、均質化（均質加圧25MPa）・殺菌し（プレート殺菌機で140℃60秒間）、保存評価用の500mlプラスチック容器に充填し、本発明の容器詰液状乳を得た。
[Comparative Example 1]
Each component shown in Table 2 below was prepared with the compounding amount shown in Table 2. The pH of the liquid milk before sterilization was 6.9, and the pH after sterilization was 6.8. At this time, the protein mass was 1.45 g/100 g, the total calcium amount was 41 mg/100 g, and the renal solute load was 14.8 mOsm/100 ml.
Liquid milk is prepared by mixing all raw materials with water at 0-70°C, and the liquid milk is homogenized (homogeneous pressure 25MPa) and sterilized (140°C for 60 seconds with a plate sterilizer), and 500 ml for storage evaluation. It was filled in a plastic container to obtain the packaged liquid milk of the present invention.
[実施例2]
下記の表３に示す各成分を、表３に示す配合量で作製した。液状乳の殺菌前のpHは7.1、殺菌後のpHは7.0であった。また、このときのたんぱく質量は1.45g/100g、カルシウム総量は45mg/100g、腎溶質負荷は14.0 mOsm/100ml、であった。
0〜70℃の水に全原料を混合して液状乳を調製し、液状乳を、均質化（均質加圧25MPa）・殺菌し（プレート殺菌機で140℃60秒間）、保存評価用の500mlプラスチック容器に充填し、本発明の容器詰液状乳を得た。
[Example 2]
The components shown in Table 3 below were prepared in the compounding amounts shown in Table 3. The pH of the liquid milk before sterilization was 7.1 and the pH after sterilization was 7.0. The protein mass was 1.45 g/100 g, total calcium was 45 mg/100 g, and renal solute load was 14.0 mOsm/100 ml.
Liquid milk is prepared by mixing all raw materials with water at 0-70°C, and the liquid milk is homogenized (homogeneous pressure 25MPa) and sterilized (140°C for 60 seconds with a plate sterilizer), and 500 ml for storage evaluation. It was filled in a plastic container to obtain the packaged liquid milk of the present invention.
[実施例３]
下記の表4に示す各成分を、表4に示す配合量で作製した。液状乳の殺菌前のpHは7.3、殺菌後のpHは7.1であった。また、このときのたんぱく質量は1.45g/100g、カルシウム総量は46mg/100g、腎溶質負荷は14.0 mOsm/100ml、であった。
0〜70℃の水に全原料を混合して液状乳を調製し、液状乳を、均質化（均質加圧25MPa）・殺菌し（プレート殺菌機で140℃60秒間）、保存評価用の500ml容量の容器に充填し、本発明の容器詰液状乳を得た。
[Example 3]
Each component shown in Table 4 below was prepared with the compounding amount shown in Table 4. The pH of the liquid milk before sterilization was 7.3 and the pH after sterilization was 7.1. At this time, the protein mass was 1.45 g/100 g, the total calcium amount was 46 mg/100 g, and the renal solute load was 14.0 mOsm/100 ml.
Liquid milk is prepared by mixing all raw materials with water at 0-70°C, and the liquid milk is homogenized (homogeneous pressure 25MPa) and sterilized (140°C for 60 seconds with a plate sterilizer), and 500 ml for storage evaluation. It was filled in a container having a capacity to obtain the packaged liquid milk of the present invention.
[実施例４]
下記の表５に示す各成分を、表５に示す配合量で作製した。液状乳の殺菌前のpHは7.2、殺菌後のpHは7.3であった。また、このときのたんぱく質量は1.45g/100g、カルシウム総量は43mg/100g、腎溶質負荷は14.8 mOsm/100ml、であった。
0〜70℃の水に全原料を混合して液状乳を調製し、液状乳を、均質化（均質加圧25MPa）・殺菌し（スチームインジェクション殺菌機で148℃４秒間）、保存評価用の125mlブリックパックに充填し、本発明の容器詰液状乳を得た。
[Example 4]
Each component shown in Table 5 below was prepared in the compounding amount shown in Table 5. The pH of the liquid milk before sterilization was 7.2 and the pH after sterilization was 7.3. At this time, the protein mass was 1.45 g/100 g, the total calcium amount was 43 mg/100 g, and the renal solute load was 14.8 mOsm/100 ml.
Liquid milk is prepared by mixing all raw materials with water at 0-70°C, and the liquid milk is homogenized (homogeneous pressure 25MPa) and sterilized (148°C for 4 seconds with a steam injection sterilizer) for storage evaluation. It was filled in a 125 ml brick pack to obtain the container-packed liquid milk of the present invention.
[試験例１]
実施例１〜４及び比較例１で得られた容器詰液状乳を室温で1週間保存し、沈殿量を評価し表６にまとめた。
[Test Example 1]
The container-packed liquid milks obtained in Examples 1 to 4 and Comparative Example 1 were stored at room temperature for 1 week, and the precipitation amount was evaluated and summarized in Table 6.
沈殿量の評価の基準を以下に示す。
◎：0.1 質量％以下
〇：0.1質量％超、0.2質量％以下
×：0.2質量％超
The criteria for evaluating the amount of precipitation are shown below.
◎: 0.1% by mass or less ○: 0.1% by mass or more, 0.2% by mass or less ×: 0.2% by mass or more
Claims (7)
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| PCT/JP2019/049766 WO2020130065A1 (en) | 2018-12-21 | 2019-12-19 | Infant formula liquid milk and method for manufacturing same, and container-packed liquid milk |
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Non-Patent Citations (4)
| Title |
|---|
| "Aptamil First Infant Milk - Ready to Feed, 70ml, Box of 24 bottles", AMAZON, JPN6020009462, 4 August 2017 (2017-08-04), pages 1 - 6, ISSN: 0004903664 * |
| HARRISON, V. C. AND PERT, G.: "Significance of milk pH in Newborn Infants", BRITISH MEDICAL JOURNAL, vol. 4, JPN6020009464, 2 December 1972 (1972-12-02), pages 515 - 518, XP055625875, ISSN: 0004903666, DOI: 10.1136/bmj.4.5839.515 * |
| MCSWEENEY, SEAMUS L., MULVIHILL, DANIEL M., AND O'CALLAGHAN, DANIEL M.: "The influence of pH on the heat-induced aggregation of model milk protein ingredient systems and mod", FOOD HYDROCOLLOIDS, vol. 18, JPN6020009463, 2004, pages 109 - 125, ISSN: 0004903665 * |
| ZIEGLER, EKHARD E., AND FOMON, SAMUEL J.: "Potential Renal Solute Load of Infant Formulas", THE JOURNAL OF NUTRITION, JPN6020009466, 1988, pages 1785 - 1788, XP055719709, ISSN: 0004903667, DOI: 10.1093/jn/119.suppl_12.1785·Source: * |
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