JP2020081762A - Medical equipment - Google Patents

Abstract

To provide medical equipment capable of treating an affected part without apprehension.SOLUTION: Medical equipment comprises: an ice slurry production part 1 for producing sherbet-like ice slurry including ice and a solution; a tube 5 for causing the ice slurry produced in the ice slurry production part to float; and a nozzle 4 which is attached to a tip of the tube for injecting the ice slurry to an affected part. The ice satisfies both conditions of (a) and (b) which are: (a) a temperature in a melting completion time is less than 0°C; and (b) a change ratio of a solute density of the solution which is generated from the ice in a melting step is within 30%. The ice slurry has a salt density at which, an osmotic pressure can act to cells of the affected part and a biological tissue.SELECTED DRAWING: Figure 2

Description

The present invention relates to a medical device for treating an affected area.

Laparoscopic surgery and laparoscopic surgery are performed to treat gastric cancer and gallbladder cancer. In laparoscopic surgery, a long incision is made in the abdomen. In laparoscopic surgery, multiple small holes are made in the abdomen. Laparoscopic surgery has the advantage that the incision is smaller and the burden on the patient can be greatly reduced (minimally invasive) compared to open surgery.

Various medical devices are used in laparoscopic surgery. For example, Patent Document 1 describes a surgery support system that uses a medical device in laparoscopic surgery. In this surgery support system, a trocar, a laparoscope, forceps (claw), etc. are used.

A trocar is a tubular instrument that is inserted through a small hole in the patient's abdomen. In laparoscopic surgery, a trocar is used to inject carbon dioxide into the abdomen to inflate the abdominal cavity. The laparoscope is an instrument that is inserted into the abdominal cavity using a trocar and includes a CCD camera and the like. Forceps are surgical instruments that are inserted through a trocar. The forceps has a scissor shape and includes a tip portion that is inserted into the abdominal cavity and a grip portion that is operated outside the abdominal cavity. The tip part grasps, pulls, or cuts blood vessels or organs.

International Publication No. 2016/13636

In the surgery support system described in Patent Document 1, bleeding may occur due to cutting of an organ or the like with forceps, and hemostasis may be difficult. Furthermore, in the surgery support system described in Patent Document 1, a high degree of technical skill is required for adhesion such as suturing the affected area after being cut. Therefore, I feel a concern about surgery by a doctor (operator) who does not have a high level of technical skill.

In the laparotomy, an electric knife, an ultrasonic knife, a high frequency knife, a radio frequency knife, etc. are used. These females generate heat by locally irradiating each energy, and heat denaturate the protein to cut living tissues or destroy cells. Therefore, in the treatment of cancer with a female, not only is it difficult to stop the bleeding, but there is a fear that the cancer cells spread in the bloodstream and diffuse, and the cancer metastasizes.

In addition, as a surgery for destroying cancer cells in cancer treatment, there is also a method in which a needle is pierced to the affected area and ethanol or an anticancer agent is injected into the affected area to chemically denature the cancer cells. Since this surgery uses an anti-cancer drug, there is a fear that it will have fatal side effects on the patient.

Besides cataract surgery, ultrasonic lens emulsification suction surgery is performed in addition to cancer surgery. In this operation, a small incision is made in the cornea, the nucleus and cortex in the lens (lens) are crushed by ultrasonic waves, suctioned and removed, and an artificial intraocular lens is inserted into the left posterior capsule. However, when the cataract progresses and the nucleus becomes hard and becomes too large, the nucleus cannot be crushed even by using ultrasonic waves, or it takes too much time to crush, and the posterior capsule is damaged. Then, there is a danger that the vitreous will come out or the crystalline lens will fall into the back of the eye.

An object of the present invention is to provide a medical device capable of treating an affected area without fear.

In order to achieve the above object, the medical device according to the present invention,
An ice slurry production section for producing a sherbet-like ice slurry containing ice and an aqueous solution,
A tube for flowing the ice slurry produced by the ice slurry producing section,
A nozzle attached to the tip of the tube and pouring ice slurry to the affected area,
Is equipped with.

The ice is
(A) The temperature at the time of completion of melting is less than 0° C. (b) The rate of change of the solute concentration of the aqueous solution generated from ice during the melting process is within 30%.

The ice slurry has a salt concentration capable of exerting an osmotic pressure on the cells and living tissues of the affected area.
In this case, the ice slurry is a mixture of ice obtained by freezing salt water having a salt concentration of 13.6 to 23.1% and salt water having a salt concentration of 13.6 to 23.1%.

The nozzle is an integral body or a separate body of a discharge path for pouring the ice slurry to the affected area and an intake path for inhaling at least one of the melted slurry in which the poured ice slurry is melted and the affected area. Prepare for.
In this case, a switching valve is provided that opens either one of the discharge passage and the suction passage and closes the other.

The medical device according to the present invention includes an ultrasonic wave generation unit that irradiates the affected area with ultrasonic waves, either integrally with or separately from the nozzle.

The ice slurry contains a contrast agent.

According to the present invention, it is possible to provide a medical device capable of treating an affected area without fear.

It is a schematic diagram showing one embodiment of a medical device of the present invention. It is the schematic which shows other embodiment of the medical device of this invention. It is a principal part expanded sectional perspective view which shows the nozzle with which the medical device of this invention was equipped, Comprising: (a), (b), (c) is a principal part expanded sectional perspective view which shows different embodiment. It is a schematic sectional drawing which shows the process of operating using the medical device of this invention, (a) is a schematic sectional drawing which shows an initial stage, (b) is a schematic sectional view which shows a middle stage, (c) shows a latter stage. It is a schematic sectional drawing.

The basic configuration of the medical device of the present invention will be described with reference to FIG. FIG. 1 is a schematic view showing an embodiment of the medical device of the present invention. The medical device of the present invention is, for example, a surgical instrument used when removing an affected part in which cancer has occurred. The medical device of the present invention includes an ice slurry production section 1, a tube 5, and a nozzle 4. The medical device further includes an ice slurry injecting section 2 and a handle section 3.

First, an outline of these will be described. The ice slurry producing unit 1 is an apparatus for producing a sherbet-like ice slurry containing ice and an aqueous solution. The tube 5 causes the ice slurry manufactured by the ice slurry manufacturing unit 1 to flow. The tube 5 has an upstream line for flowing the ice slurry from the ice slurry manufacturing section 1 to the ice slurry injecting section 2 and a downstream line for flowing the ice slurry from the ice slurry injecting section 2 to the handle section 3. The tubes 5 of both lines are surrounded by a heat insulating material so that the inside of the tubes 5 is not affected by the outside air. The tube 5 in the downstream line has flexibility.

The handle portion 3 is in the form of a pipe through which ice slurry flows, and is used by an operator such as a doctor to hold the handle portion 3 and change the direction of the tip portion of the nozzle 4. The nozzle 4 is attached to the tip of the tube 5 via a handle and pours ice slurry onto the affected area.

Although not shown in the drawings, they will be described in detail below. The ice slurry production unit 1 includes a flake ice production device and an ice storage tank. The flake ice production device produces hybrid ice from a liquid containing an aqueous solution containing a solute (hereinafter referred to as "brine"), and produces flake ice from the hybrid ice. In the ice storage tank, flake ice and brine are mixed at a predetermined ratio to produce ice slurry.

Brine is an aqueous solution containing a solute in a solvent such as water, for example, an aqueous solution of sodium chloride (salt water), an aqueous solution of calcium chloride, an aqueous solution of magnesium chloride, an aqueous solution of ethylene glycol, etc., and has a feature of having a low freezing point. Have Hybrid ice is instantly frozen ice that has not been given time to separate the solute and solvent in the brine. In the present invention, “ice” is hybrid ice or flake ice produced by a flake ice production device.

Ice is liquid ice containing an aqueous solution containing a solute, which satisfies the following conditions (a) and (b).
(A) The temperature at the completion of melting is less than 0° C. (b) The change rate of the solute concentration of the aqueous solution generated from ice during the melting process is within 30%

The condition (a) will be described. Since ice is produced from an aqueous solution containing a solute, its freezing point is lower than that of fresh water containing no solute. Therefore, ice has a characteristic that the temperature at the completion of melting is less than 0°C. "Temperature at the completion of melting" means that the ice generated by the flake ice making device is placed in an environment above the melting point (for example, room temperature and atmospheric pressure) to start melting the ice and all the ice melts. It refers to the temperature of the water when it becomes water.

The temperature at the time of completion of melting is not particularly limited as long as it is less than 0°C, and can be appropriately changed by adjusting the type and concentration of the solute. The temperature at the time of completion of melting is preferably lower as the cooling capacity is higher. However, when it is necessary to prevent damage to the object to be cooled, such as a human organ, it is preferable that the freezing point of ice be close to the temperature of the object to be cooled.

The condition (b) will be described. Since the ice produced by the flake ice manufacturing apparatus is made of liquid ice containing an aqueous solution containing a solute, it has a characteristic that the elution rate of the solute during the melting process is small. Specifically, the rate of change in the solute concentration of the aqueous solution generated from ice during the melting process is 30%. The “rate of change in solute concentration of the aqueous solution generated from ice during the melting process” means the ratio of the concentration of the aqueous solution at the completion of melting to the solute concentration in the aqueous solution generated at any time during the melting process. "Solute concentration" means the concentration of the mass of solute in an aqueous solution.

The change rate of the solute concentration in the ice produced by the flake ice manufacturing apparatus is not particularly limited as long as it is within 30%. However, from the viewpoint that the smaller the rate of change is, the higher the ice purity of the aqueous solution having the reduced freezing point, that is, the higher the cooling capacity, the rate of change of the solute concentration is within 25%. Good.

The type of solute contained in the ice produced by the flake ice manufacturing apparatus is not particularly limited as long as it is a solute when water is used as a solvent, and is appropriately selected according to a desired freezing point, use of ice to be used, and the like. be able to. Examples of solutes include solid solutes and liquid solutes, and typical solid solutes include salts (inorganic salts, organic salts, etc.). Among the salts, sodium chloride (NaCl) is particularly preferable because it does not excessively reduce the freezing point temperature and is suitable for cooling the affected area. In addition, salt is contained in seawater, which is easy to procure. Examples of liquid solutes include ethylene glycol and the like. The solute may be contained alone or in combination of two or more.

The liquid constituting the ice produced by the flake ice manufacturing apparatus may be a liquid containing oil in addition to the aqueous solution containing the solute. Examples of such a liquid include raw milk, industrial wastes containing water and oil (waste milk, etc.). When the liquid is raw milk, it is preferable in that the organoleptic properties of the milk when it is eaten are improved. As described above, it is speculated that the reason why the organoleptic property is improved is that the oil (fat) contained in the raw milk is trapped in ice. The ice produced by the flake ice manufacturing apparatus may be composed only of frozen aqueous solution containing the solute.

Further, the ice produced by the flake ice manufacturing apparatus may be ice of an aqueous solution containing two or more solutes having different freezing point depression degrees. In this case, the ice produced by the flake ice manufacturing apparatus may be a mixture of ice of an aqueous solution containing one solute and ice of an aqueous solution containing the other solute. In this case, for example, by adding ice of an aqueous solution containing sodium chloride as a solute having a different freezing point depression to ethylene glycol to ice of an aqueous solution containing ethylene glycol as a solute, it is possible to delay the melting of the ice in the aqueous solution containing ethylene glycol. it can.

Alternatively, the ice generated by the flake ice manufacturing apparatus may be ice of an aqueous solution obtained by dissolving two or more solutes in the same aqueous solution. It is also useful when two or more solutes having different freezing point depression degrees are used in combination, and when the melting point of ice of an aqueous solution containing the target solute is lowered. For example, when salt is used as a solute, the melting point of ice in saline can be lowered by using a solute capable of further lowering the melting point than that of sodium chloride (ethylene glycol, calcium chloride, etc.). It is possible to achieve temperatures around -30°C, which cannot be achieved with ice alone. The ratio of two or more solutes having different freezing point depression degrees can be appropriately changed depending on the purpose.

In addition, the ice produced by the flake ice manufacturing apparatus is kept stable at a temperature equal to or lower than the freezing point of fresh water, that is, the non-separated state can be maintained for a long time. Therefore, the liquid that constitutes the ice produced by the flake ice manufacturing apparatus, in addition to the aqueous solution containing the above solute, further, if the liquid is oil, the oil has a long-lasting uniform state, that is, The state of not separating can be maintained for a long time.

The concentration of the solute contained in the ice produced by the flake ice manufacturing apparatus is not particularly limited, and can be appropriately selected depending on the type of the solute, the desired freezing point, the intended use of the ice used, and the like. For example, when salt is used as the solute, the concentration of salt is preferably 0.5% (w/v) or more from the viewpoint that the freezing point of the aqueous solution can be further lowered and a high cooling capacity can be obtained.

When the liquid that composes the ice produced by the flake ice making device further contains oil, the ratio of water to oil in the liquid is not particularly limited, and is appropriately selected within the range of 1:99 to 99:1, for example. You may.

Here, the outline of the flake ice manufacturing apparatus will be described. Although not shown, the flake ice making device includes an ice making unit that rapidly freezes brine to produce thin ice-like hybrid ice, an injection unit that pours brine to the ice making unit, and a thin ice-like hybrid ice making unit. And a blade for scraping it off.

The ice making unit may be in the form of a cylindrical vertical drum or a plate in a vertical posture. The temperature of the inner peripheral surface of the vertical drum and the surface of the plate is cooled to -20°C to -25°C. Copper or a copper alloy having high thermal conductivity is adopted as a member forming the vertical drum or the plate. The surface of the vertical drum and the metal plate is plated with wear-resistant metal such as chrome.

The spraying unit intermittently sprays the brine to the ice making unit. Brine is instantaneously produced in hybrid ice in the ice making section. Flake ice is produced by the blade scraping the ice off the ice making section. The flake ice falls into the ice storage tank located just below the ice making section. The hybrid ice and the flake ice are collectively referred to as “ice” hereinafter.

The brine stored in the brine storage tank is also supplied to the ice storage tank. In the ice storage tank, the flake ice manufactured by the flake ice manufacturing device and the brine supplied from the brine storage tank are mixed at a predetermined ratio. In this way, a sherbet-like ice slurry is produced in the ice storage tank.

The ice slurry containing ice produced by the flake ice manufacturing apparatus may contain other components of the above ice, for example, by containing water in addition to the above ice, it is composed of a mixture of ice and water. May be. For example, when the water further contains the same solute as the solute contained in ice, the concentration of the solute in ice and the concentration of the solute in water are preferably close to each other. The reason is as follows.

When the solute concentration of ice is higher than the solute concentration of water, the temperature of the ice is lower than the saturation freezing point of water, so that the water freezes immediately after mixing water with a low solute concentration. On the other hand, when the solute concentration of ice is lower than that of water, the saturation freezing point of water is lower than the saturation freezing point of ice, so that the ice melts and the temperature of the ice slurry consisting of a mixture of ice and water decreases. To do. That is, in order to prevent the state of the mixture of ice and water (the state of ice slurry) from changing, it is preferable that the solute concentrations of ice and water to be mixed are approximately the same, as described above. Further, in the case of a mixture of ice and water, the water may be one in which the ice is melted or may be prepared separately, but one in which the ice is melted Is preferred.

Specifically, when the ice slurry containing ice produced by the flake ice manufacturing apparatus is composed of a mixture of ice and water, the ratio of the concentration of solute in ice and the concentration of solute in water is 75: It is more preferably 25 to 20:80, and most preferably 50:50. In particular, when using sodium chloride as the solute, it is preferable that the ratio of the concentration of the solute in ice to the concentration of the solute in water is within the above range.

If the ice slurry is made from frozen salt water, the salinity is between 13.6 and 23.1%. The ice slurry having this salt concentration can act a permeation tag on cells and living tissues in the affected area.

The ice slurry containing ice produced by the flake ice production apparatus preferably further contains a solid having a higher thermal conductivity than the ice produced by the above flake ice production apparatus. However, since the ice produced by the flake ice manufacturing apparatus has a high cooling capacity as described above, it is useful in that it is possible to cool for a long time while obtaining a cooling capacity for a short time by a solid having high thermal conductivity. Is.

Examples of solids having a higher thermal conductivity than ice produced by the flake ice manufacturing apparatus include metals (aluminum, silver, copper, gold, duralumin, antimony, cadmium, zinc, tin, bismuth, tungsten, titanium, iron, Lead, nickel, platinum, magnesium, molybdenum, zirconium, beryllium, indium, niobium, chromium, cobalt, iridium, palladium), alloys (steel (carbon steel, chrome steel, nickel steel, chrome nickel steel, silicon steel, tungsten steel, Manganese steel, etc.), nickel chrome alloy, aluminum bronze, gunmetal, brass, manganin, nickel silver, constantan, solder, alumel, chromel, monel metal, platinum iridium, etc.), silicon, carbon, ceramics (alumina ceramics, forsterite ceramics, steatite) Ceramics, etc.), marble, bricks (magnesia bricks, Korhalt bricks, etc.), and the like, which have higher thermal conductivity than ice produced by the flake ice manufacturing apparatus.

Further, the solid having a higher thermal conductivity than ice produced by the flake ice manufacturing apparatus is more preferably a solid having a thermal conductivity of 2.3 W/m K or more, and a thermal conductivity of 50 W/m K or more. ) Is more preferable, the solid having a thermal conductivity of 100 W/m K or higher is even more preferable, and the solid having a thermal conductivity of 200 W/m K or higher is still more preferable. Is more preferably 200 W/m K or more, and particularly preferably a solid having a thermal conductivity of 400 W/m K or more.

If the ice slurry containing ice produced by the flake ice manufacturing apparatus contains a solid having a higher thermal conductivity than the ice, as described above, it is suitable for cooling for a long time even if it contains many solids, For example, the mass of solids having a higher thermal conductivity than the ice produced by the flake ice maker/the mass of ice produced by the flake ice maker contained in the ice slurry (or the ice of the present invention contained in the ice slurry). The total mass with the liquid containing the aqueous solution) may be 1/10000 or more.

The solid contained in the ice slurry containing the ice produced by the flake ice manufacturing apparatus may have any shape, but is preferably in the form of particles. The solid may be contained in the ice produced by the flake ice manufacturing apparatus in a form contained in the ice, or may be contained in a form contained in the outside of the ice. Since it is easier to directly contact the object to be cooled when it is included in the form included in, the cooling capacity becomes higher. For this reason, it is preferable that it is contained in a form contained outside the ice.

When the ice slurry containing ice produced by the flake ice production apparatus contains the above solid, it may be mixed with the above solid after producing ice by the flake ice production apparatus, or water as a raw material in advance. The ice may be produced by the flake ice making device in the state of being mixed with the ice.

Here, the medical device of the present invention will be described. As shown in FIG. 1, the ice slurry produced in the ice slurry producing section 1 flows into the ice slurry injecting section 2 through the tube 5. Although not shown, the ice slurry injecting unit 2 includes a tank that stores the ice slurry and a pump that causes the ice slurry in the tank to flow to the handle unit 3.

The ice slurry injecting unit 2 is separated from the ice slurry producing unit 1 so as to be movable. Even if the ice-slurry manufacturing unit 1 is too large to move, the ice-slurry injection unit 2 separated from the ice-slurry manufacturing unit 1 can be individually brought into a plurality of operating rooms. Further, a plurality of ice slurry injecting units 2 are provided, and one ice slurry producing unit 1 can inject the ice slurry into each ice slurry injecting unit 2.

The ice slurry in the ice slurry injecting section 2 flows to the pipe-shaped handle section 3 by the tube 5. The tube 5 between the ice slurry injecting section 2 and the handle section 3 is flexible so that the handle section 3 can be moved to any position. The handle portion 3 is sized to have an outer diameter and a length that the operator can easily hold. The handle portion 3 is provided with a switch 31 for driving and stopping the pump of the ice slurry injecting portion 2.

A nozzle 4 is attached to the tip of the handle portion 3. The nozzle 4 has a small outer diameter that easily enters the patient's body, and has a needle shape having an inner diameter through which the ice slurry flows. The tip of the nozzle 4 is obliquely cut so as to easily stick to the affected area. The nozzle 4 is simply a cylinder when used only for pouring ice slurry. When the switch 31 of the handle portion 3 is turned on, the ice slurry is poured out from the tip portion of the nozzle 4, and when the switch 31 is turned off, the ice slurry is not poured from the tip portion of the nozzle 4.

Next, a modified example (another embodiment) of the medical device will be described with reference to FIGS. 2 and 3. FIG. 2 is a schematic view showing another embodiment of the medical device of the present invention. FIG. 3 is a schematic sectional perspective view showing a nozzle 4 provided in the medical device of the present invention, and FIG. 3( a ), FIG. 3( b ), and FIG. 3( c) are schematic sectional views showing different modified examples. It is a perspective view.

As shown in FIG. 2, the medical device according to the modified example includes a suction unit 6. The suction unit 6 separates and sucks the molten slurry, which is obtained by melting the ice slurry after freezing the affected area, and the affected area in which cancer has developed, from an organ such as an organ. The dissolved slurry and the affected part sucked by the suction part 6 are discharged to a tank (not shown). The suction part 6 and the handle part 3 are connected by a tube 5.

The medical device of the modified example includes a nozzle 4 for sucking a dissolved slurry and an affected area where cancer has developed. As shown in FIG. 3, the nozzle 4 has a discharge path 4a for discharging the ice slurry flowing from the ice slurry injecting section 2 to the affected area, and an intake path 4b for inhaling at least one of the molten slurry and the affected area. I have it. The handle portion 3 is provided with a switching valve 32 for opening one of the discharge passage 4a and the suction passage 4b and closing the other.

The nozzle 4 (41) shown in FIG. 3(a) has a concentric double tube structure, and includes a passage 41a on the center side and a passage 41b on the outer side. For example, the passage 41a on the center side is used as the discharge passage 4a and the passage 41b on the outside is used as the suction passage 4b, so that the ice slurry toward the affected area can be kept in a heat-insulated state. On the contrary, the passage 41a on the center side is used as the suction passage 4b and the passage 41b on the outer side is used as the discharge passage 4a.

The nozzle 4 (42) shown in FIG. 3( b) is divided into two parts in the lengthwise direction in the cylinder, and one passage 42 a and the other passage 42 b are provided. One passage 41a is used as the discharge passage 4a, and the other passage 42b is used as the suction passage 4b. One passage 42a, which is the discharge passage 4a, may have at least heat insulating properties, and the other passage 42b may also have heat insulating properties.

The nozzle 4 (43) shown in FIG. 3(c) has a plurality of tubular portions provided in the cylinder in the length direction, and is divided into one passage 43a including the center side and the other passage 43b in the tubular portion. Be done. One passage 43a or the other passage 43b serves as the discharge passage 4a, and the other passage 43b or the one passage 43a serves as the suction passage 4b.

In any of the nozzles 4 (41, 42, 43), the discharge passage 4a communicates with the ice slurry injecting portion 2 by the tube 5, and the suction passage 4b communicates with the suction portion 6 by the tube 5.

The switch 31 provided in the nozzle 4 causes the changeover valve 32 to cause the ice slurry to flow from the ice slurry injecting section 2 to the discharge path 4a of the nozzle 4, or to return from the affected area to the dissolved slurry and the affected area where the cancer has developed. Is made to flow into the suction passage 4b, and the pump of the ice slurry injecting section 2 is switched to be driven or stopped.

Here, with reference to FIG. 4, a method of removing an affected part in which cancer has developed in the body using the medical device of the present invention will be described. 4A and 4B are schematic cross-sectional views showing a process of performing an operation using the medical device of the present invention, in which FIG. 4A is a schematic cross-sectional view showing an initial stage, FIG. 4B is a schematic cross-sectional view showing a middle stage, and FIG. [Fig. 3] is a schematic cross-sectional view showing a latter stage.

Here, a case will be described where a medical device equipped with the nozzle 4 shown in FIG. 3 is used to remove an affected area where cancer has occurred by laparoscopic surgery. The ice making part of the flake ice making device is cooled to about -25°C, and the ice slurry is cooled to, for example, -9.8°C to -21.3°C. The ice slurry is poured out from the tip of the nozzle 4.

As shown in FIG. 4, in the laparoscopic surgery, the trocar 101 is inserted into each of a plurality of small holes formed in the abdomen, and carbon dioxide gas is injected into the abdomen to inflate the abdominal cavity. A laparoscope 102 having a CCD camera is inserted into one of the trocars 101, and the inside of the abdominal cavity is displayed on the screen of a monitor (not shown). By looking at the screen, the operator can confirm where in the abdominal cavity the cancer has developed, that is, where the affected area A in which the cancer has developed is.

The surgeon grasps the handle portion 3 and operates. As shown in FIG. 4A, the operator inserts the nozzle 4 from another trocar 101 toward the affected area A. Next, as shown in FIG. 4( b ), the operator inserts the tip portion of the nozzle 4 into the affected area A and turns on the switch 31 to remove the discharge path 4 a of the nozzle 4 from the ice slurry injecting section 2. The flowing ice slurry is injected into the affected area A from the tip.

Since the ice slurry is cooled to −9.8° C. to −21.3° C., the affected area A is rapidly cooled and the protein is denatured. Furthermore, the cancer cells are destroyed by the action of osmotic pressure due to the salt content of the ice slurry. Cancer cells become necrotic when frozen and destroyed.

The affected area A in which the cancer has developed thaws after a while. By repeatedly freezing and thawing the affected area A, the effect of cryonecrosis can be enhanced. By switching the switch 31 of the nozzle 4, the melted slurry, which is melted after the ice slurry freezes the affected area A, is sucked into the suction passage 4b. Thereafter, by switching the switch 31, the ice slurry is caused to flow from the ice slurry injecting section 2 to the nozzle 4, and the cancer cells in the affected area A are destroyed by protein denaturation and osmotic pressure. Cancer cells are frozen and destroyed multiple times to enhance the effect of necrosis.

As shown in FIG. 4C, the affected area A containing necrotic cancer cells and the dissolved slurry are sucked into the inhalation passage. Cancer cells are used for pathological examination and the like. When the affected area A is large, the affected area A can be completely removed by repeating suction of the affected area A and injection of ice slurry. Then, the nozzle 4 and the laparoscope 102 are removed from the abdominal cavity. Then, after the trocar 101 is removed, the operation ends.

Although the embodiments of the present invention have been described above, the present invention is not limited to the configurations described in the above embodiments, and is considered within the scope of matters described in the claims. It also includes other possible embodiments and modifications. Further, various modifications and combinations of the above-described embodiments may be made without departing from the scope of the present invention.

When the nozzle 4 of the above-described embodiment particularly sucks the dissolved slurry and the affected area A, the ultrasonic wave generating portion may be provided integrally with or separately from the nozzle 4. The ultrasonic wave generation part accelerates the separation of the affected part A from an organ such as an organ by irradiating the affected part A necrotized by the injection of ice slurry with ultrasonic waves. The separated affected part A is easily sucked by the nozzle 4.

In the above-described embodiment, in the laparoscopic surgery, the laparoscope 102 is inserted into a certain trocar 101 and the inside of the abdominal cavity is projected on the screen. However, even in image diagnosis that does not use the laparoscope 102, the nozzle 4 can be inserted into the affected area A. In this case, it is preferable to include a contrast agent in the ice slurry. With the contrast agent, it is possible to visually observe how the ice slurry has penetrated into the affected area A.

In the embodiment described above, the ice slurry injecting unit 2 is provided. However, the ice slurry may flow directly from the ice slurry manufacturing section 1 to the handle section 3. In the above-described embodiment, the nozzle 4 and the handle portion 3 are separate bodies. However, the nozzle 4 and the handle portion 3 may be integrated. Further, the nozzle 4 may have a rounded shape instead of the shape in which the tip end is obliquely cut depending on the site to be operated. Further, the nozzle 4 may have a thick tubular shape that is not a needle shape when, for example, the affected area A in which cancer has developed on the skin surface is removed.

Further, it goes without saying that the rate of change of the solute concentration of ice contained in the ice slurry of the present invention and the salt concentration of ice frozen from salt water can be appropriately changed. Further, the medical device of the present invention can be used in various operations such as tumor operation other than cancer operation, for example, animal operation.

In the modification described above, the nozzle 4 has the discharge passage 4a and the suction passage 4b. However, the nozzle 4 may be configured with two separate discharge passages 4a and suction passages 4b. Furthermore, in the case of treating the surface of the skin, the nozzle 4 does not necessarily have to have the suction passage 4b as shown in FIG. The medical device in that case does not include the suction unit 6.

In summary, the medical device to which the present invention is applied is
An ice slurry production section 1 for producing a sherbet-shaped ice slurry containing ice and an aqueous solution;
A tube 5 for flowing the ice slurry produced in the ice slurry producing section 1;
A nozzle 4 attached to the tip of the tube 5 for pouring ice slurry into the affected area A;
Is equipped with.

In this medical device, the sherbet-shaped ice slurry manufactured in the ice slurry manufacturing unit 1 flows in the tube 5 and is discharged from the nozzle 4. The tip of the nozzle 4 is applied to the affected area A, and the affected area A is rapidly cooled by an ice slurry to denature the protein for treatment.

In a medical device to which the present invention is applied,
The ice is
(A) The temperature at the time of completion of melting is less than 0° C. (b) The rate of change of the solute concentration of the aqueous solution generated from ice during the melting process is within 30%.

This medical device can produce ice containing an aqueous solution having a lowered freezing point when the ice satisfies both conditions (a) and (b).

In a medical device to which the present invention is applied,
The ice slurry has a salt concentration capable of exerting an osmotic pressure on the cells and living tissue of the affected area A.
In this case, the ice slurry is a mixture of ice obtained by freezing salt water having a salt concentration of 13.6 to 23.1% and salt water having a salt concentration of 13.6 to 23.1%. Is preferred.

In this medical device, the ice slurry causes an osmotic pressure to act on the cells and living tissue of the affected area A, so that the ice slurry permeates into the cells and living tissue of the affected area A and rapidly cools the cells and living tissue of the affected area A. The protein can be denatured by

The medical device to which the present invention is applied,
The nozzle 4 has a discharge passage 4a for discharging the ice slurry to the affected area A, and a suction passage 4b for sucking at least one of the melted slurry of the poured ice slurry and the affected area A, Is provided as a single body or as a separate body.

In this medical device, the ice slurry is poured out from the discharge passage 4a provided in the nozzle 4, the affected area can be rapidly cooled by the ice slurry, and at least one of the molten slurry and the affected area A is sucked from the suction passage 4b. At least one of the molten slurry and the affected area A can be taken out.

The medical device to which the present invention is applied,
An ultrasonic wave generator for irradiating the affected area A with ultrasonic waves is provided integrally with or separately from the nozzle 4.

In this medical device, ultrasonic waves generated by the ultrasonic wave generator are applied to the affected area A, and the trunk A can be easily separated from organs such as organs.

In a medical device to which the present invention is applied,
The ice slurry contains a contrast agent.

According to this medical device, the ice slurry containing the contrast agent is reflected in the image diagnosis, and it is possible to easily grasp the pouring condition of the ice slurry.

1... Ice slurry manufacturing section 2... Ice slurry injection section 3... Handle section 32... Switching valve 4... Nozzle 4a... Discharge path 4b... Suction path 5... Tube 6... Suction section A... Affected area

Claims (8)

An ice slurry production section for producing a sherbet-like ice slurry containing ice and an aqueous solution,
A tube for flowing the ice slurry produced by the ice slurry producing section,
A nozzle attached to the tip of the tube and pouring ice slurry to the affected area,
Is equipped with,
Medical equipment. The ice is
(A) the temperature at the time of completion of melting is less than 0° C. (b) the change rate of the solute concentration of the aqueous solution generated from ice during the melting process is within 30%, both conditions are satisfied,
The medical device according to claim 1. The ice slurry is a salt concentration capable of exerting an osmotic pressure on the cells and living tissues of the affected area,
The medical device according to claim 1 or 2. The ice slurry is a mixture of ice obtained by freezing salt water having a salt concentration of 13.6 to 23.1% and salt water having a salt concentration of 13.6 to 23.1%.
The medical device according to claim 3. The nozzle is an integral body or a separate body of a discharge path for pouring the ice slurry to the affected area and an intake path for inhaling at least one of the melted slurry in which the poured ice slurry is melted and the affected area. Prepare in
The medical device according to any one of claims 1 to 4. A switching valve that opens one of the discharge passage and the suction passage and closes the other;
The medical device according to claim 5. An ultrasonic wave generating unit for irradiating the affected area with ultrasonic waves is provided integrally with or separately from the nozzle,
The medical device according to any one of claims 1 to 6. The ice slurry contains a contrast agent,
The medical device according to any one of claims 1 to 7.

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