JP2020079218A - Oil-in-water emulsion cosmetic - Google Patents
Oil-in-water emulsion cosmetic Download PDFInfo
- Publication number
- JP2020079218A JP2020079218A JP2018213712A JP2018213712A JP2020079218A JP 2020079218 A JP2020079218 A JP 2020079218A JP 2018213712 A JP2018213712 A JP 2018213712A JP 2018213712 A JP2018213712 A JP 2018213712A JP 2020079218 A JP2020079218 A JP 2020079218A
- Authority
- JP
- Japan
- Prior art keywords
- oil
- component
- water emulsion
- water
- cosmetic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 148
- 239000007764 o/w emulsion Substances 0.000 title claims abstract description 95
- 239000002245 particle Substances 0.000 claims abstract description 38
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract description 35
- 239000004215 Carbon black (E152) Substances 0.000 claims abstract description 24
- 229930195733 hydrocarbon Natural products 0.000 claims abstract description 24
- 150000002430 hydrocarbons Chemical class 0.000 claims abstract description 24
- 239000004094 surface-active agent Substances 0.000 claims abstract description 24
- XOJVVFBFDXDTEG-UHFFFAOYSA-N pristane Chemical compound CC(C)CCCC(C)CCCC(C)CCCC(C)C XOJVVFBFDXDTEG-UHFFFAOYSA-N 0.000 claims abstract description 20
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 19
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 17
- 239000000194 fatty acid Substances 0.000 claims abstract description 17
- 229930195729 fatty acid Natural products 0.000 claims abstract description 17
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 17
- 125000001165 hydrophobic group Chemical group 0.000 claims abstract description 17
- 238000004519 manufacturing process Methods 0.000 claims abstract description 16
- 239000007788 liquid Substances 0.000 claims abstract description 15
- 238000000034 method Methods 0.000 claims abstract description 12
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229940032094 squalane Drugs 0.000 claims abstract description 12
- 229940057995 liquid paraffin Drugs 0.000 claims abstract description 11
- 229940056211 paraffin Drugs 0.000 claims abstract description 11
- 239000012188 paraffin wax Substances 0.000 claims abstract description 11
- DSEKYWAQQVUQTP-XEWMWGOFSA-N (2r,4r,4as,6as,6as,6br,8ar,12ar,14as,14bs)-2-hydroxy-4,4a,6a,6b,8a,11,11,14a-octamethyl-2,4,5,6,6a,7,8,9,10,12,12a,13,14,14b-tetradecahydro-1h-picen-3-one Chemical compound C([C@H]1[C@]2(C)CC[C@@]34C)C(C)(C)CC[C@]1(C)CC[C@]2(C)[C@H]4CC[C@@]1(C)[C@H]3C[C@@H](O)C(=O)[C@@H]1C DSEKYWAQQVUQTP-XEWMWGOFSA-N 0.000 claims abstract description 10
- LEEDMQGKBNGPDN-UHFFFAOYSA-N 2-methylnonadecane Chemical compound CCCCCCCCCCCCCCCCCC(C)C LEEDMQGKBNGPDN-UHFFFAOYSA-N 0.000 claims abstract description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 66
- 239000000839 emulsion Substances 0.000 claims description 42
- -1 liquid paraffin Substances 0.000 claims description 23
- 239000000203 mixture Substances 0.000 claims description 21
- 239000004264 Petrolatum Substances 0.000 claims description 15
- 238000000265 homogenisation Methods 0.000 claims description 15
- 229940066842 petrolatum Drugs 0.000 claims description 15
- 235000019271 petrolatum Nutrition 0.000 claims description 15
- 238000009775 high-speed stirring Methods 0.000 claims description 13
- 125000004432 carbon atom Chemical group C* 0.000 claims description 12
- BWWBBIDHNCOGMM-JWJAOTBVSA-N [Na].NCCCC[C@H](N)C(O)=O.CCCCCCCCCCCC(=O)OC(=O)CC[C@H](N)C(=O)OC(=O)CCCCCCCCCCC Chemical compound [Na].NCCCC[C@H](N)C(O)=O.CCCCCCCCCCCC(=O)OC(=O)CC[C@H](N)C(=O)OC(=O)CCCCCCCCCCC BWWBBIDHNCOGMM-JWJAOTBVSA-N 0.000 claims description 2
- 206010040880 Skin irritation Diseases 0.000 abstract description 6
- 230000036556 skin irritation Effects 0.000 abstract description 6
- 231100000475 skin irritation Toxicity 0.000 abstract description 6
- 229940099259 vaseline Drugs 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 42
- 238000012360 testing method Methods 0.000 description 34
- 230000000052 comparative effect Effects 0.000 description 29
- 239000012071 phase Substances 0.000 description 29
- 239000003921 oil Substances 0.000 description 28
- 235000019198 oils Nutrition 0.000 description 28
- 238000001704 evaporation Methods 0.000 description 19
- 230000008020 evaporation Effects 0.000 description 19
- 238000004945 emulsification Methods 0.000 description 14
- 238000011156 evaluation Methods 0.000 description 14
- 229920002125 Sokalan® Polymers 0.000 description 11
- 239000006071 cream Substances 0.000 description 7
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 6
- 239000006210 lotion Substances 0.000 description 6
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 6
- 230000001629 suppression Effects 0.000 description 6
- 230000004888 barrier function Effects 0.000 description 5
- 239000003974 emollient agent Substances 0.000 description 5
- 238000009472 formulation Methods 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000002562 thickening agent Substances 0.000 description 5
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 4
- 239000004909 Moisturizer Substances 0.000 description 4
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 4
- 230000001804 emulsifying effect Effects 0.000 description 4
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 4
- 230000014759 maintenance of location Effects 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- 230000001333 moisturizer Effects 0.000 description 4
- 239000008213 purified water Substances 0.000 description 4
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 3
- 239000004472 Lysine Substances 0.000 description 3
- KWYUFKZDYYNOTN-UHFFFAOYSA-M Potassium hydroxide Chemical compound [OH-].[K+] KWYUFKZDYYNOTN-UHFFFAOYSA-M 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 230000003796 beauty Effects 0.000 description 3
- 230000000903 blocking effect Effects 0.000 description 3
- 229960001631 carbomer Drugs 0.000 description 3
- 239000003795 chemical substances by application Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 239000000499 gel Substances 0.000 description 3
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 3
- 239000004615 ingredient Substances 0.000 description 3
- 238000005259 measurement Methods 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 239000002994 raw material Substances 0.000 description 3
- 230000000475 sunscreen effect Effects 0.000 description 3
- 239000000516 sunscreening agent Substances 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 2
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- ULQISTXYYBZJSJ-UHFFFAOYSA-N 12-hydroxyoctadecanoic acid Chemical compound CCCCCCC(O)CCCCCCCCCCC(O)=O ULQISTXYYBZJSJ-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- JVTIXNMXDLQEJE-UHFFFAOYSA-N 2-decanoyloxypropyl decanoate 2-octanoyloxypropyl octanoate Chemical compound C(CCCCCCC)(=O)OCC(C)OC(CCCCCCC)=O.C(=O)(CCCCCCCCC)OCC(C)OC(=O)CCCCCCCCC JVTIXNMXDLQEJE-UHFFFAOYSA-N 0.000 description 2
- 206010001497 Agitation Diseases 0.000 description 2
- 206010013786 Dry skin Diseases 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 235000021314 Palmitic acid Nutrition 0.000 description 2
- 239000002202 Polyethylene glycol Chemical group 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 235000021355 Stearic acid Nutrition 0.000 description 2
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 125000000217 alkyl group Chemical group 0.000 description 2
- MBMBGCFOFBJSGT-KUBAVDMBSA-N all-cis-docosa-4,7,10,13,16,19-hexaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCC(O)=O MBMBGCFOFBJSGT-KUBAVDMBSA-N 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- OGBUMNBNEWYMNJ-UHFFFAOYSA-N batilol Chemical compound CCCCCCCCCCCCCCCCCCOCC(O)CO OGBUMNBNEWYMNJ-UHFFFAOYSA-N 0.000 description 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
- 239000010495 camellia oil Substances 0.000 description 2
- 229940082500 cetostearyl alcohol Drugs 0.000 description 2
- 229960000541 cetyl alcohol Drugs 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- 229960000735 docosanol Drugs 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 230000037336 dry skin Effects 0.000 description 2
- SHZIWNPUGXLXDT-UHFFFAOYSA-N ethyl hexanoate Chemical compound CCCCCC(=O)OCC SHZIWNPUGXLXDT-UHFFFAOYSA-N 0.000 description 2
- 235000008524 evening primrose extract Nutrition 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 2
- 229920002674 hyaluronan Polymers 0.000 description 2
- 229960003160 hyaluronic acid Drugs 0.000 description 2
- 230000001771 impaired effect Effects 0.000 description 2
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 2
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 2
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- 238000005191 phase separation Methods 0.000 description 2
- 229920001223 polyethylene glycol Chemical group 0.000 description 2
- 229920001282 polysaccharide Polymers 0.000 description 2
- 239000005017 polysaccharide Substances 0.000 description 2
- 150000004804 polysaccharides Chemical class 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 238000013112 stability test Methods 0.000 description 2
- 239000008117 stearic acid Substances 0.000 description 2
- 210000000434 stratum corneum Anatomy 0.000 description 2
- 229920001059 synthetic polymer Polymers 0.000 description 2
- HLZKNKRTKFSKGZ-UHFFFAOYSA-N tetradecan-1-ol Chemical compound CCCCCCCCCCCCCCO HLZKNKRTKFSKGZ-UHFFFAOYSA-N 0.000 description 2
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 2
- OULAJFUGPPVRBK-UHFFFAOYSA-N tetratriacontyl alcohol Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCO OULAJFUGPPVRBK-UHFFFAOYSA-N 0.000 description 2
- DUXYWXYOBMKGIN-UHFFFAOYSA-N trimyristin Chemical compound CCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCC DUXYWXYOBMKGIN-UHFFFAOYSA-N 0.000 description 2
- GZIFEOYASATJEH-VHFRWLAGSA-N δ-tocopherol Chemical compound OC1=CC(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-VHFRWLAGSA-N 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- JWZZKOKVBUJMES-UHFFFAOYSA-N (+-)-Isoprenaline Chemical compound CC(C)NCC(O)C1=CC=C(O)C(O)=C1 JWZZKOKVBUJMES-UHFFFAOYSA-N 0.000 description 1
- WCDDVEOXEIYWFB-VXORFPGASA-N (2s,3s,4r,5r,6r)-3-[(2s,3r,5s,6r)-3-acetamido-5-hydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5,6-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@@H]1C[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](C(O)=O)O[C@@H](O)[C@H](O)[C@H]1O WCDDVEOXEIYWFB-VXORFPGASA-N 0.000 description 1
- BJDAUCLANVMIOB-UHFFFAOYSA-N (3-decanoyloxy-2,2-dimethylpropyl) decanoate Chemical compound CCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCC BJDAUCLANVMIOB-UHFFFAOYSA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- OOWQBDFWEXAXPB-IBGZPJMESA-N 1-O-hexadecyl-sn-glycerol Chemical compound CCCCCCCCCCCCCCCCOC[C@@H](O)CO OOWQBDFWEXAXPB-IBGZPJMESA-N 0.000 description 1
- FRPZMMHWLSIFAZ-UHFFFAOYSA-N 10-undecenoic acid Chemical compound OC(=O)CCCCCCCCC=C FRPZMMHWLSIFAZ-UHFFFAOYSA-N 0.000 description 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
- WAYINTBTZWQNSN-UHFFFAOYSA-N 11-methyldodecyl 3,5,5-trimethylhexanoate Chemical compound CC(C)CCCCCCCCCCOC(=O)CC(C)CC(C)(C)C WAYINTBTZWQNSN-UHFFFAOYSA-N 0.000 description 1
- 229940114072 12-hydroxystearic acid Drugs 0.000 description 1
- ZONJATNKKGGVSU-UHFFFAOYSA-N 14-methylpentadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCC(O)=O ZONJATNKKGGVSU-UHFFFAOYSA-N 0.000 description 1
- FUTGDWNFCMWSJT-UHFFFAOYSA-N 2,3-bis(14-methylpentadecanoyloxy)propyl 14-methylpentadecanoate Chemical compound CC(C)CCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCC(C)C FUTGDWNFCMWSJT-UHFFFAOYSA-N 0.000 description 1
- JNAYPSWVMNJOPQ-UHFFFAOYSA-N 2,3-bis(16-methylheptadecanoyloxy)propyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C JNAYPSWVMNJOPQ-UHFFFAOYSA-N 0.000 description 1
- DGSZGZSCHSQXFV-UHFFFAOYSA-N 2,3-bis(2-ethylhexanoyloxy)propyl 2-ethylhexanoate Chemical compound CCCCC(CC)C(=O)OCC(OC(=O)C(CC)CCCC)COC(=O)C(CC)CCCC DGSZGZSCHSQXFV-UHFFFAOYSA-N 0.000 description 1
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 1
- HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 1
- WLAMNBDJUVNPJU-UHFFFAOYSA-N 2-methylbutyric acid Chemical compound CCC(C)C(O)=O WLAMNBDJUVNPJU-UHFFFAOYSA-N 0.000 description 1
- LEACJMVNYZDSKR-UHFFFAOYSA-N 2-octyldodecan-1-ol Chemical compound CCCCCCCCCCC(CO)CCCCCCCC LEACJMVNYZDSKR-UHFFFAOYSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- DBULKOHECOANKB-UHFFFAOYSA-N 3,4-bis(dodecoxycarbonyl)hexanedioic acid Chemical compound CCCCCCCCCCCCOC(=O)C(CC(O)=O)C(CC(O)=O)C(=O)OCCCCCCCCCCCC DBULKOHECOANKB-UHFFFAOYSA-N 0.000 description 1
- UIVPNOBLHXUKDX-UHFFFAOYSA-N 3,5,5-trimethylhexyl 3,5,5-trimethylhexanoate Chemical compound CC(C)(C)CC(C)CCOC(=O)CC(C)CC(C)(C)C UIVPNOBLHXUKDX-UHFFFAOYSA-N 0.000 description 1
- CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
- CFKMVGJGLGKFKI-UHFFFAOYSA-N 4-chloro-m-cresol Chemical compound CC1=CC(O)=CC=C1Cl CFKMVGJGLGKFKI-UHFFFAOYSA-N 0.000 description 1
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 241001237961 Amanita rubescens Species 0.000 description 1
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 1
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 1
- 235000021357 Behenic acid Nutrition 0.000 description 1
- 239000005711 Benzoic acid Substances 0.000 description 1
- DPUOLQHDNGRHBS-UHFFFAOYSA-N Brassidinsaeure Natural products CCCCCCCCC=CCCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-UHFFFAOYSA-N 0.000 description 1
- NPDHNQFIAGGKQV-AAHCGPSESA-L C(CCCCCCCCCCC)(=O)N([C@@H](CCC(=O)[O-])C(=O)[O-])C(CCCCCCCCCCC)=O.N[C@@H](CCCCN)C(=O)O.[Na+].[Na+] Chemical compound C(CCCCCCCCCCC)(=O)N([C@@H](CCC(=O)[O-])C(=O)[O-])C(CCCCCCCCCCC)=O.N[C@@H](CCCCN)C(=O)O.[Na+].[Na+] NPDHNQFIAGGKQV-AAHCGPSESA-L 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- 241000284156 Clerodendrum quadriloculare Species 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- GZIFEOYASATJEH-UHFFFAOYSA-N D-delta tocopherol Natural products OC1=CC(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 GZIFEOYASATJEH-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
- 102000002322 Egg Proteins Human genes 0.000 description 1
- 108010000912 Egg Proteins Proteins 0.000 description 1
- 102000016942 Elastin Human genes 0.000 description 1
- 108010014258 Elastin Proteins 0.000 description 1
- URXZXNYJPAJJOQ-UHFFFAOYSA-N Erucic acid Natural products CCCCCCC=CCCCCCCCCCCCC(O)=O URXZXNYJPAJJOQ-UHFFFAOYSA-N 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- DBVJJBKOTRCVKF-UHFFFAOYSA-N Etidronic acid Chemical compound OP(=O)(O)C(O)(C)P(O)(O)=O DBVJJBKOTRCVKF-UHFFFAOYSA-N 0.000 description 1
- YCKRFDGAMUMZLT-UHFFFAOYSA-N Fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 229920000855 Fucoidan Polymers 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 239000004166 Lanolin Substances 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- 235000018330 Macadamia integrifolia Nutrition 0.000 description 1
- 240000000912 Macadamia tetraphylla Species 0.000 description 1
- 235000003800 Macadamia tetraphylla Nutrition 0.000 description 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
- MKYBYDHXWVHEJW-UHFFFAOYSA-N N-[1-oxo-1-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)propan-2-yl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(C(C)NC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 MKYBYDHXWVHEJW-UHFFFAOYSA-N 0.000 description 1
- NIPNSKYNPDTRPC-UHFFFAOYSA-N N-[2-oxo-2-(2,4,6,7-tetrahydrotriazolo[4,5-c]pyridin-5-yl)ethyl]-2-[[3-(trifluoromethoxy)phenyl]methylamino]pyrimidine-5-carboxamide Chemical compound O=C(CNC(=O)C=1C=NC(=NC=1)NCC1=CC(=CC=C1)OC(F)(F)F)N1CC2=C(CC1)NN=N2 NIPNSKYNPDTRPC-UHFFFAOYSA-N 0.000 description 1
- FCWRAGWRNLDKBB-UQIIZPHYSA-N N[C@@H](CCC(=O)OC(CCCCCCCCCCC)=O)C(=O)OC(CCCCCCCCCCC)=O.[Na] Chemical compound N[C@@H](CCC(=O)OC(CCCCCCCCCCC)=O)C(=O)OC(CCCCCCCCCCC)=O.[Na] FCWRAGWRNLDKBB-UQIIZPHYSA-N 0.000 description 1
- 241000772415 Neovison vison Species 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical group OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 1
- 244000014047 Polianthes tuberosa Species 0.000 description 1
- 235000016067 Polianthes tuberosa Nutrition 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
- 235000019484 Rapeseed oil Nutrition 0.000 description 1
- 235000019774 Rice Bran oil Nutrition 0.000 description 1
- 235000019485 Safflower oil Nutrition 0.000 description 1
- 244000044822 Simmondsia californica Species 0.000 description 1
- 235000004433 Simmondsia californica Nutrition 0.000 description 1
- 229920002385 Sodium hyaluronate Polymers 0.000 description 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 1
- 241000270666 Testudines Species 0.000 description 1
- 235000006732 Torreya nucifera Nutrition 0.000 description 1
- 244000111306 Torreya nucifera Species 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 125000003158 alcohol group Chemical group 0.000 description 1
- 239000000783 alginic acid Substances 0.000 description 1
- 235000010443 alginic acid Nutrition 0.000 description 1
- 229920000615 alginic acid Polymers 0.000 description 1
- 229960001126 alginic acid Drugs 0.000 description 1
- 150000004781 alginic acids Chemical class 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 125000005250 alkyl acrylate group Chemical group 0.000 description 1
- JAZBEHYOTPTENJ-JLNKQSITSA-N all-cis-5,8,11,14,17-icosapentaenoic acid Chemical compound CC\C=C/C\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O JAZBEHYOTPTENJ-JLNKQSITSA-N 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 1
- 239000001099 ammonium carbonate Substances 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000010775 animal oil Substances 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 229940064004 antiseptic throat preparations Drugs 0.000 description 1
- 239000008346 aqueous phase Substances 0.000 description 1
- 229940114079 arachidonic acid Drugs 0.000 description 1
- 235000021342 arachidonic acid Nutrition 0.000 description 1
- 235000021302 avocado oil Nutrition 0.000 description 1
- 239000008163 avocado oil Substances 0.000 description 1
- IWWCATWBROCMCW-UHFFFAOYSA-N batyl alcohol Natural products CCCCCCCCCCCCCCCCCCOC(O)CO IWWCATWBROCMCW-UHFFFAOYSA-N 0.000 description 1
- 229940116226 behenic acid Drugs 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 235000010233 benzoic acid Nutrition 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- WMNULTDOANGXRT-UHFFFAOYSA-N bis(2-ethylhexyl) butanedioate Chemical compound CCCCC(CC)COC(=O)CCC(=O)OCC(CC)CCCC WMNULTDOANGXRT-UHFFFAOYSA-N 0.000 description 1
- 239000007844 bleaching agent Substances 0.000 description 1
- KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 1
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 1
- KHAVLLBUVKBTBG-UHFFFAOYSA-N caproleic acid Natural products OC(=O)CCCCCCCC=C KHAVLLBUVKBTBG-UHFFFAOYSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229940075510 carbopol 981 Drugs 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 229920003123 carboxymethyl cellulose sodium Polymers 0.000 description 1
- 229940063834 carboxymethylcellulose sodium Drugs 0.000 description 1
- 239000000679 carrageenan Substances 0.000 description 1
- 235000010418 carrageenan Nutrition 0.000 description 1
- 229920001525 carrageenan Polymers 0.000 description 1
- 229940113118 carrageenan Drugs 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 150000001765 catechin Chemical class 0.000 description 1
- 239000002738 chelating agent Substances 0.000 description 1
- OOWQBDFWEXAXPB-UHFFFAOYSA-N chimyl alcohol Natural products CCCCCCCCCCCCCCCCOCC(O)CO OOWQBDFWEXAXPB-UHFFFAOYSA-N 0.000 description 1
- 229960003260 chlorhexidine Drugs 0.000 description 1
- KXKPYJOVDUMHGS-OSRGNVMNSA-N chondroitin sulfate Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](OS(O)(=O)=O)[C@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](C(O)=O)O1 KXKPYJOVDUMHGS-OSRGNVMNSA-N 0.000 description 1
- 229940059329 chondroitin sulfate Drugs 0.000 description 1
- 239000010630 cinnamon oil Substances 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005687 corn oil Nutrition 0.000 description 1
- 239000002285 corn oil Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 239000002385 cottonseed oil Substances 0.000 description 1
- 229920006037 cross link polymer Polymers 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 235000010389 delta-tocopherol Nutrition 0.000 description 1
- 230000002951 depilatory effect Effects 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 229940105984 diethylhexyl succinate Drugs 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 229940031569 diisopropyl sebacate Drugs 0.000 description 1
- 239000000539 dimer Substances 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- 150000002009 diols Chemical class 0.000 description 1
- XFKBBSZEQRFVSL-UHFFFAOYSA-N dipropan-2-yl decanedioate Chemical compound CC(C)OC(=O)CCCCCCCCC(=O)OC(C)C XFKBBSZEQRFVSL-UHFFFAOYSA-N 0.000 description 1
- 235000020669 docosahexaenoic acid Nutrition 0.000 description 1
- 229940090949 docosahexaenoic acid Drugs 0.000 description 1
- LQZZUXJYWNFBMV-UHFFFAOYSA-N dodecan-1-ol Chemical compound CCCCCCCCCCCCO LQZZUXJYWNFBMV-UHFFFAOYSA-N 0.000 description 1
- DLAHAXOYRFRPFQ-UHFFFAOYSA-N dodecyl benzoate Chemical compound CCCCCCCCCCCCOC(=O)C1=CC=CC=C1 DLAHAXOYRFRPFQ-UHFFFAOYSA-N 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 235000013345 egg yolk Nutrition 0.000 description 1
- 210000002969 egg yolk Anatomy 0.000 description 1
- 235000020673 eicosapentaenoic acid Nutrition 0.000 description 1
- 229960005135 eicosapentaenoic acid Drugs 0.000 description 1
- JAZBEHYOTPTENJ-UHFFFAOYSA-N eicosapentaenoic acid Natural products CCC=CCC=CCC=CCC=CCC=CCCCC(O)=O JAZBEHYOTPTENJ-UHFFFAOYSA-N 0.000 description 1
- 229920002549 elastin Polymers 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- DPUOLQHDNGRHBS-KTKRTIGZSA-N erucic acid Chemical compound CCCCCCCC\C=C/CCCCCCCCCCCC(O)=O DPUOLQHDNGRHBS-KTKRTIGZSA-N 0.000 description 1
- 239000010696 ester oil Substances 0.000 description 1
- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 229940045761 evening primrose extract Drugs 0.000 description 1
- 239000010475 evening primrose oil Substances 0.000 description 1
- 229940089020 evening primrose oil Drugs 0.000 description 1
- 230000001747 exhibiting effect Effects 0.000 description 1
- 210000004709 eyebrow Anatomy 0.000 description 1
- 229930003935 flavonoid Natural products 0.000 description 1
- 235000017173 flavonoids Nutrition 0.000 description 1
- 229910052731 fluorine Inorganic materials 0.000 description 1
- 239000011737 fluorine Substances 0.000 description 1
- 210000000245 forearm Anatomy 0.000 description 1
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 235000013922 glutamic acid Nutrition 0.000 description 1
- 239000004220 glutamic acid Substances 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 229940075507 glyceryl monostearate Drugs 0.000 description 1
- 125000003827 glycol group Chemical group 0.000 description 1
- 210000004209 hair Anatomy 0.000 description 1
- 239000008269 hand cream Substances 0.000 description 1
- ACGUYXCXAPNIKK-UHFFFAOYSA-N hexachlorophene Chemical compound OC1=C(Cl)C=C(Cl)C(Cl)=C1CC1=C(O)C(Cl)=CC(Cl)=C1Cl ACGUYXCXAPNIKK-UHFFFAOYSA-N 0.000 description 1
- 229960004068 hexachlorophene Drugs 0.000 description 1
- SFFVATKALSIZGN-UHFFFAOYSA-N hexadecan-7-ol Chemical compound CCCCCCCCCC(O)CCCCCC SFFVATKALSIZGN-UHFFFAOYSA-N 0.000 description 1
- XJNUECKWDBNFJV-UHFFFAOYSA-N hexadecyl 2-ethylhexanoate Chemical compound CCCCCCCCCCCCCCCCOC(=O)C(CC)CCCC XJNUECKWDBNFJV-UHFFFAOYSA-N 0.000 description 1
- 229940014041 hyaluronate Drugs 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 229940100554 isononyl isononanoate Drugs 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- XUGNVMKQXJXZCD-UHFFFAOYSA-N isopropyl palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC(C)C XUGNVMKQXJXZCD-UHFFFAOYSA-N 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 239000004310 lactic acid Substances 0.000 description 1
- 235000014655 lactic acid Nutrition 0.000 description 1
- 229940039717 lanolin Drugs 0.000 description 1
- 235000019388 lanolin Nutrition 0.000 description 1
- 239000000171 lavandula angustifolia l. flower oil Substances 0.000 description 1
- 239000000944 linseed oil Substances 0.000 description 1
- 235000021388 linseed oil Nutrition 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 239000000845 maltitol Substances 0.000 description 1
- 235000010449 maltitol Nutrition 0.000 description 1
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 1
- 229940035436 maltitol Drugs 0.000 description 1
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 230000003020 moisturizing effect Effects 0.000 description 1
- 239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
- 150000002762 monocarboxylic acid derivatives Chemical class 0.000 description 1
- 229940043348 myristyl alcohol Drugs 0.000 description 1
- 229920005615 natural polymer Polymers 0.000 description 1
- 239000010466 nut oil Substances 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 125000005702 oxyalkylene group Chemical group 0.000 description 1
- FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 239000003504 photosensitizing agent Substances 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 235000013824 polyphenols Nutrition 0.000 description 1
- 239000004810 polytetrafluoroethylene Substances 0.000 description 1
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 235000011181 potassium carbonates Nutrition 0.000 description 1
- 235000011118 potassium hydroxide Nutrition 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 229940079889 pyrrolidonecarboxylic acid Drugs 0.000 description 1
- 125000001453 quaternary ammonium group Chemical group 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 239000008165 rice bran oil Substances 0.000 description 1
- 235000005713 safflower oil Nutrition 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 229960004889 salicylic acid Drugs 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 239000008159 sesame oil Substances 0.000 description 1
- 235000011803 sesame oil Nutrition 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 230000036620 skin dryness Effects 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229940010747 sodium hyaluronate Drugs 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- JXAZAUKOWVKTLO-UHFFFAOYSA-L sodium pyrosulfate Chemical compound [Na+].[Na+].[O-]S(=O)(=O)OS([O-])(=O)=O JXAZAUKOWVKTLO-UHFFFAOYSA-L 0.000 description 1
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 125000000542 sulfonic acid group Chemical group 0.000 description 1
- RWSOTUBLDIXVET-UHFFFAOYSA-O sulfonium group Chemical group [SH3+] RWSOTUBLDIXVET-UHFFFAOYSA-O 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical group S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 239000011975 tartaric acid Substances 0.000 description 1
- 235000002906 tartaric acid Nutrition 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- SHWIJIJNPFXOFS-UHFFFAOYSA-N thiotaurine Chemical compound NCCS(O)(=O)=S SHWIJIJNPFXOFS-UHFFFAOYSA-N 0.000 description 1
- 230000036962 time dependent Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- 239000002383 tung oil Substances 0.000 description 1
- 229960002703 undecylenic acid Drugs 0.000 description 1
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 1
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 235000019165 vitamin E Nutrition 0.000 description 1
- 239000011709 vitamin E Substances 0.000 description 1
- 229940046009 vitamin E Drugs 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
- 239000002446 δ-tocopherol Substances 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、水中油型乳化化粧料に関する。 The present invention relates to an oil-in-water emulsion cosmetic.
皮膚は生体の表面にあって、直接外界に接していることから、絶えず色々な刺激にさらされている。皮膚はこのような刺激から生体を保護し、身体の働きを周囲の変化に順応させる働きをしている。 Since the skin is on the surface of a living body and is in direct contact with the outside world, it is constantly exposed to various stimuli. The skin protects the living body from such irritation and adapts the work of the body to changes in the environment.
このように皮膚は生体の最外層に位置していることから、生体内部に比べて乾燥した外部環境に曝されている。そうした環境の中で、皮膚、特に角質層には、適度に水分を保持する水分保持機能及び生体内部の水分が失われないようにする水分バリア機能が備わっている。 Since the skin is located in the outermost layer of the living body as described above, it is exposed to an external environment that is dry compared with the inside of the living body. In such an environment, the skin, particularly the stratum corneum, has a water retention function of appropriately retaining water and a water barrier function of preventing loss of water inside the living body.
しかし、乾燥した皮膚では水分バリア機能が低下している。そこで、化粧料によって皮膚表面からの過剰な水分蒸発を防ぐことが望まれる。 However, the moisture barrier function is reduced in dry skin. Therefore, it is desired that cosmetics prevent excessive evaporation of water from the skin surface.
化粧品や医薬品の原料として、皮膚表面からの水分蒸発を抑制する機能、すなわち、閉塞力を備えたワセリン、流動パラフィン、パラフィン、スクワラン、水素添加スクワランといった炭化水素系油性成分が汎用されている。しかし、このような炭化水素系油性成分は、それ単体で使用すると伸びが悪く、皮膚へのなじみが悪いといった不快な使用感を生じる。 As a raw material for cosmetics and pharmaceuticals, hydrocarbon-based oily components such as petrolatum, liquid paraffin, paraffin, squalane, and hydrogenated squalane, which have a function of suppressing water evaporation from the skin surface, that is, have an occluding force, are widely used. However, when such a hydrocarbon-based oily component is used alone, it has a poor elongation and is uncomfortable to be applied to the skin.
そこで、炭化水素系油性成分を水中油型乳化物にすることで使用感を改善する試みがなされている。しかし、炭化水素系油性成分の閉塞力を十分に発揮しようと配合量を増やそうとした場合、やはりぬるつきが残り、皮膚へのなじみが悪くなるばかりでなく、経時安定性を保つことができなくなるという問題が生じる。 Therefore, attempts have been made to improve the feeling of use by making the hydrocarbon-based oily component an oil-in-water emulsion. However, if an attempt is made to increase the amount of the hydrocarbon-based oily component to fully exert its occluding force, slimyness will remain and the skin will not fit well and the stability over time will not be maintained. The problem arises.
上記問題を解決するものとして、例えば、特許文献１には、１０ｗｔ％のワセリンと、合計で０．５ｗｔ％の界面活性剤とを含有し、かつ、高速撹拌機の処理後に８０℃にて高圧ホモジナイズ処理に供して得られる、内油相粒子径が約０．５μｍである、液状乳化型皮膚用組成物が記載されている。 As a solution to the above problem, for example, Patent Document 1 contains 10 wt% of petrolatum and 0.5 wt% of surfactant in total, and high pressure at 80° C. after treatment with a high-speed stirrer. A liquid emulsion-type skin composition having an inner oil phase particle size of about 0.5 μm, which is obtained by subjecting to homogenization treatment, is described.
しかし、特許文献１に記載の液状乳化型皮膚用組成物は、ワセリンに対する界面活性剤の割合が５ｗｔ％と高いものである。そこで、水分バリア機能を期待して、ワセリンの含有量を増やそうとした場合には、界面活性剤を多量に配合することとなり、界面活性剤の量に起因する皮膚刺激性が生じ得るという問題がある。 However, the liquid emulsion type skin composition described in Patent Document 1 has a high ratio of the surfactant to petrolatum of 5 wt %. Therefore, when it is attempted to increase the content of petrolatum in anticipation of a water barrier function, a large amount of surfactant is added, which causes skin irritation due to the amount of surfactant. is there.
また、特許文献１に記載の液状乳化型皮膚用組成物を製造する方法は、乳化粒子の粒子径を小さくするために、８０℃での高圧ホモジナイズ処理を含む方法である。このような高温での高圧ホモジナイズ処理は、製造時のエネルギー効率が悪く、さらに作業上の危険性が大きいという問題がある。 Further, the method for producing the liquid emulsion-type skin composition described in Patent Document 1 is a method including high-pressure homogenization treatment at 80° C. in order to reduce the particle size of the emulsified particles. The high-pressure homogenization treatment at such a high temperature has a problem that the energy efficiency at the time of production is low and the work risk is high.
そこで、本発明は、閉塞力が認められ、使用感が良好でありながらも、皮膚刺激性の危険性が低い、水中油型乳化化粧料を提供することを、発明が解決しようとする第１の課題とする。 Therefore, the present invention aims to provide an oil-in-water emulsion cosmetic which has an occlusion force and has a good feeling in use, but has a low risk of skin irritation. And the subject.
また、本発明は、製造時のエネルギー効率が良好であり、かつ、作業上の危険性が低減された、水中油型乳化化粧料の製造方法を提供することを、発明が解決しようとする第２の課題とする。 Further, the present invention is to provide a method for producing an oil-in-water type emulsion cosmetic, which has good energy efficiency during production, and has reduced work risk, and the invention is intended to solve the same. There are two issues.
本発明者らは、上記の課題を解決しようとして、種々検討したところ、使用感の観点から、炭化水素系油性成分の乳化に分子内に複数個の長鎖疎水基及び親水基を有する多鎖多親水基型界面活性剤を使用するという着想に至った。しかし、炭化水素系油性成分と多鎖多親水基型界面活性剤とを撹拌混合して予備乳化した後に高圧ホモジナイズ処理に供することを試みようとしたところ、油浮きが生じて、高圧ホモジナイズ処理を実施することができなかった。 The inventors of the present invention have made various investigations in order to solve the above problems, and from the viewpoint of the feeling of use, a multi-chain having a plurality of long-chain hydrophobic groups and hydrophilic groups in the molecule for emulsifying a hydrocarbon-based oily component. The idea came to use a multi-hydrophilic group type surfactant. However, when an attempt was made to stir and mix the hydrocarbon-based oily component and the multi-chain poly-hydrophilic group-type surfactant and then to subject it to high-pressure homogenization treatment, oil floating occurred, and high-pressure homogenization treatment was performed. It could not be carried out.
かかる問題に直面した本発明者らは、試行錯誤を繰り返して鋭意研究開発に励んだところ、遂に、炭化水素系油性成分及び多鎖多親水基型界面活性剤に加えて、高級脂肪酸及び高級アルコールをさらに配合することにより、予備乳化後の油浮きを回避することができることを見出した。 The inventors of the present invention, which faced such a problem, have devoted themselves to research and development by repeating trial and error, and finally, in addition to the hydrocarbon-based oily component and the multi-chain poly-hydrophilic group-type surfactant, the higher fatty acid and the higher alcohol. It was found that the oil floating after the pre-emulsification can be avoided by further blending.
驚くべきことに、本発明者らは、これらを配合した水中油型乳化化粧料を作製するにあたり、炭化水素系油性成分の量に対する多鎖多親水基型界面活性剤の量の割合を比較的小さくすることができることを見出した。さらに驚くべきことに、本発明者らは、上記成分を混合して予備乳化した後に高圧ホモジナイズ処理に供する際に、室温であっても微細エマルションを作製することが可能であることを見出した。 Surprisingly, the present inventors have made the ratio of the amount of the multi-chain polyhydrophilic group-type surfactant relatively to the amount of the hydrocarbon-based oily component in preparing the oil-in-water type emulsion cosmetic containing these. We found that it can be made smaller. Even more surprisingly, the present inventors have found that when the above components are mixed and pre-emulsified and then subjected to a high-pressure homogenization treatment, a fine emulsion can be produced even at room temperature.
本発明者らは、このような知見を基に、本発明の課題を解決するものとして、炭化水素系油性成分、高級脂肪酸、高級アルコール及び多鎖多親水基型界面活性剤を含有し、かつ、乳化粒子の粒子径が小さい水中油型乳化化粧料及び該水中油型乳化化粧料の製造方法を創作することに成功した。本発明は、これらの知見及び成功例に基づき完成された発明である。 The present inventors, based on such knowledge, as a solution to the problems of the present invention, containing a hydrocarbon-based oily component, a higher fatty acid, a higher alcohol and a multi-chain polyhydrophilic group type surfactant, and The present invention succeeded in creating an oil-in-water emulsion cosmetic having a small particle size of emulsion particles and a method for producing the oil-in-water emulsion cosmetic. The present invention has been completed based on these findings and successful examples.
したがって、本発明の一態様によれば、以下の［１］〜［１１］の水中油型乳化化粧料及び方法が提供される。
［１］下記の成分（Ａ）〜成分（Ｄ）を含有し、かつ、乳化粒子のメディアン径（Ｄ５０）が１．０μｍ未満である、水中油型乳化化粧料。
（Ａ）ワセリン、流動パラフィン、パラフィン、流動イソパラフィン、流動オゾケライト、プリスタン、スクワラン及び水素添加スクワランからなる群から選ばれる少なくとも１種の炭化水素系油性成分
（Ｂ）高級脂肪酸
（Ｃ）高級アルコール
（Ｄ）少なくとも２個の長鎖疎水基及び少なくとも２個の親水基を分子内に有する多鎖多親水基型界面活性剤
［２］前記成分（Ａ）の含有量は、５質量％以上である、［１］に記載の水中油型乳化化粧料。
［３］前記成分（Ｄ）の含有量は、０．００５質量％〜１．０質量％である、［１］〜［２］のいずれか１項に記載の水中油型乳化化粧料。
［４］前記成分（Ａ）の量に対する前記成分（Ｄ）の量の割合（成分（Ｄ）／成分（Ａ））は、０．００５〜０．０５である、［１］〜［３］のいずれか１項に記載の水中油型乳化化粧料。
［５］前記成分（Ｂ）は炭素数が１２〜２０である高級脂肪酸であり、及び／又は、前記成分（Ｃ）は炭素数が６〜２０である高級アルコールである、［１］〜［４］のいずれか１項に記載の水中油型乳化化粧料。
［６］前記成分（Ｄ）は、ジラウロイルグルタミン酸リシンナトリウムを含む多鎖多親水基型界面活性剤である、［１］〜［５］のいずれか１項に記載の水中油型乳化化粧料。
［７］前記水中油型乳化化粧料は、皮膚用水中油型乳化化粧料である、［１］〜［６］のいずれか１項に記載の水中油型乳化化粧料。
［８］下記の成分（Ａ）〜成分（Ｄ）を高速撹拌処理に供して予備乳化液を得る工程；及び
前記予備乳化液を高圧ホモジナイズ処理に供して、乳化粒子のメディアン径（Ｄ５０）が１．０μｍ未満である水中油型乳化化粧料を得る工程
を含む、水中油型乳化化粧料の製造方法。
（Ａ）ワセリン、流動パラフィン、パラフィン、流動イソパラフィン、流動オゾケライト、プリスタン、スクワラン及び水素添加スクワランからなる群から選ばれる少なくとも１種の炭化水素系油性成分
（Ｂ）高級脂肪酸
（Ｃ）高級アルコール
（Ｄ）少なくとも２個の長鎖疎水基及び少なくとも２個の親水基を分子内に有する多鎖多親水基型界面活性剤
［９］下記の成分（Ａ）〜成分（Ｄ）を高速撹拌処理に供して予備乳化液を得る工程を含む、予備乳化液の油浮きを抑制する方法。
（Ａ）ワセリン、流動パラフィン、パラフィン、流動イソパラフィン、流動オゾケライト、プリスタン、スクワラン及び水素添加スクワランからなる群から選ばれる少なくとも１種の炭化水素系油性成分
（Ｂ）高級脂肪酸
（Ｃ）高級アルコール
（Ｄ）少なくとも２個の炭素数が５〜２０個である長鎖疎水基及び少なくとも２個の親水基を分子内に有する多鎖多親水基型界面活性剤
［１０］上記［１］〜［７］のいずれか１項に記載の水中油型乳化化粧料を、皮膚に塗布する工程を含む、皮膚表面からの水分蒸発を防ぐ方法。
［１１］乳化粒子のメディアン径（Ｄ５０）が１．０μｍ未満である、水中油型乳化化粧料を製造するための、下記の成分（Ａ）〜成分（Ｄ）の組み合わせの使用。
（Ａ）ワセリン、流動パラフィン、パラフィン、流動イソパラフィン、流動オゾケライト、プリスタン、スクワラン及び水素添加スクワランからなる群から選ばれる少なくとも１種の炭化水素系油性成分
（Ｂ）高級脂肪酸
（Ｃ）高級アルコール
（Ｄ）少なくとも２個の長鎖疎水基及び少なくとも２個の親水基を分子内に有する多鎖多親水基型界面活性剤
Therefore, according to one aspect of the present invention, the following oil-in-water emulsified cosmetics and methods are provided.
[1] An oil-in-water emulsion cosmetic containing the following components (A) to (D) and having a median diameter (D50) of emulsified particles of less than 1.0 μm.
(A) At least one hydrocarbon-based oily component (B) higher fatty acid (C) higher alcohol (D) selected from the group consisting of petrolatum, liquid paraffin, paraffin, liquid isoparaffin, liquid ozokerite, pristane, squalane, and hydrogenated squalane. ) Multi-chain polyhydrophilic group type surfactant having at least two long chain hydrophobic groups and at least two hydrophilic groups in the molecule [2] The content of the component (A) is 5% by mass or more, The oil-in-water emulsified cosmetic composition according to [1].
[3] The oil-in-water type emulsion cosmetic according to any one of [1] to [2], in which the content of the component (D) is 0.005% by mass to 1.0% by mass.
[4] The ratio of the amount of the component (D) to the amount of the component (A) (component (D)/component (A)) is 0.005 to 0.05, [1] to [3]. The oil-in-water emulsion cosmetic according to any one of 1.
[5] The component (B) is a higher fatty acid having 12 to 20 carbon atoms, and/or the component (C) is a higher alcohol having 6 to 20 carbon atoms, [1] to [1] [4] The oil-in-water emulsion cosmetic according to any one of [4].
[6] The oil-in-water emulsified cosmetic composition according to any one of [1] to [5], wherein the component (D) is a multi-chain polyhydrophilic group-type surfactant containing sodium dilauroylglutamate lysine. ..
[7] The oil-in-water emulsion cosmetic according to any one of [1] to [6], wherein the oil-in-water emulsion cosmetic is an oil-in-water emulsion cosmetic for skin.
[8] A step of subjecting the following components (A) to (D) to a high-speed stirring treatment to obtain a preliminary emulsion, and subjecting the preliminary emulsion to a high-pressure homogenization treatment so that the median diameter (D50) of the emulsion particles is A method for producing an oil-in-water emulsion cosmetic, which comprises a step of obtaining an oil-in-water emulsion cosmetic having a thickness of less than 1.0 μm.
(A) At least one hydrocarbon-based oily component (B) higher fatty acid (C) higher alcohol (D) selected from the group consisting of petrolatum, liquid paraffin, paraffin, liquid isoparaffin, liquid ozokerite, pristane, squalane, and hydrogenated squalane. ) A multi-chain polyhydrophilic group type surfactant having at least two long-chain hydrophobic groups and at least two hydrophilic groups in the molecule [9] The following components (A) to (D) are subjected to high-speed stirring treatment. A method for suppressing oil floating of a preliminary emulsion, comprising the step of obtaining a preliminary emulsion.
(A) At least one hydrocarbon-based oily component (B) higher fatty acid (C) higher alcohol (D) selected from the group consisting of petrolatum, liquid paraffin, paraffin, liquid isoparaffin, liquid ozokerite, pristane, squalane, and hydrogenated squalane. ) Multi-chain polyhydrophilic group type surfactant having at least two long-chain hydrophobic groups having 5 to 20 carbon atoms and at least two hydrophilic groups in the molecule [10] above [1] to [7] A method for preventing evaporation of water from the skin surface, which comprises a step of applying the oil-in-water emulsion cosmetic according to any one of 1. to skin.
[11] Use of a combination of the following components (A) to (D) for producing an oil-in-water emulsion cosmetic in which the median diameter (D50) of the emulsified particles is less than 1.0 μm.
(A) At least one hydrocarbon-based oily component (B) higher fatty acid (C) higher alcohol (D) selected from the group consisting of petrolatum, liquid paraffin, paraffin, liquid isoparaffin, liquid ozokerite, pristane, squalane, and hydrogenated squalane. ) Multi-chain polyhydrophilic group type surfactant having at least two long chain hydrophobic groups and at least two hydrophilic groups in the molecule
本発明の一態様である水中油型乳化化粧料は、皮膚表面からの水分蒸発を抑制する閉塞力が認められながらも、皮膚へ塗布した際のぬるつきが少なく、なじみが良いことによる使用感が良好であり、かつ、界面活性剤の量が炭化水素系油性成分の量に対して少量であることによる皮膚刺激性の危険性が低いことから、使用者や利用シーンを選ばずに日常的に利用されることが期待できる。また、本発明の一態様である水中油型乳化化粧料は、経時安定性に優れていることから、長期間の使用及び保存が可能である。 The oil-in-water emulsified cosmetic according to one aspect of the present invention has a feeling of use due to its low familiarity when applied to the skin and good familiarity, even though an occlusive force for suppressing evaporation of water from the skin surface is observed. Is good, and the risk of skin irritation due to the small amount of surfactant relative to the amount of hydrocarbon-based oily component is low, so it can be used on a daily basis regardless of user or usage scene. Can be expected to be used for. In addition, the oil-in-water emulsion cosmetic according to one aspect of the present invention has excellent stability over time, and thus can be used and stored for a long period of time.
本発明の一態様である水中油型乳化化粧料によれば、クリーム、乳液、化粧水、ジェル、美容液などのスキンケア化粧品や、ファンデーションなどのメーキャップ化粧品といった種々の化粧品形態をとることにより、使用者の皮膚の水分バリア機能を改善又は維持することが期待できる。 According to the oil-in-water emulsion cosmetic that is one aspect of the present invention, it is used by taking various cosmetic forms such as skin care cosmetics such as cream, emulsion, lotion, gel, and beauty essence, and makeup cosmetics such as foundation. It can be expected to improve or maintain the moisture barrier function of human skin.
本発明の一態様である方法によれば、高圧ホモジナイズ処理をする際に、加温せずに室温などで実施することが可能であることから、製造時のエネルギー効率を良好にして、かつ、作業上の危険性を低減して、水中油型乳化化粧料を製造することが可能である。 According to the method of one embodiment of the present invention, when performing high-pressure homogenization treatment, it is possible to carry out at room temperature or the like without heating, thus improving energy efficiency during production, and, It is possible to produce an oil-in-water type emulsion cosmetic while reducing the work risk.
以下、本発明の一態様である水中油型乳化化粧料及び方法の詳細について説明するが、本発明の技術的範囲は本項目の事項によってのみに限定されるものではなく、本発明はその目的を達成する限りにおいて種々の態様をとり得る。 Hereinafter, details of the oil-in-water emulsified cosmetic and method which are one aspect of the present invention will be described, but the technical scope of the present invention is not limited only by the items of this item, and the present invention Various modes can be adopted as long as the above is achieved.
本明細書における各用語は、別段の定めがない限り、当業者により通常用いられている意味で使用され、不当に限定的な意味を有するものとして解釈されるべきではない。 Unless otherwise specified, each term used in the present specification has a meaning commonly used by those skilled in the art, and should not be interpreted as having an unreasonably limited meaning.
例えば、「及び／又は」との用語は、列記した複数の関連項目のいずれか１つ、又は２つ以上の任意の組み合わせ若しくは全ての組み合わせを意味する。 For example, the term "and/or" means any one of the listed related items, or any combination or all of two or more of the related items.
「含有量」は、濃度と同義であり、水中油型乳化化粧料の全体量に対する成分の量の割合を意味する。本明細書では、別段の定めがない限り、含有量の単位は「質量％（ｗｔ％）」を意味する。 The "content" is synonymous with the concentration and means the ratio of the amount of the component to the total amount of the oil-in-water emulsion cosmetic. In the present specification, unless otherwise specified, the unit of content means “mass% (wt %)”.
数値範囲の「〜」は、本明細書において、その前後の数値を含む範囲であり、例えば、「０質量％〜１００質量％」は、０質量％以上であり、かつ、１００質量％以下である範囲を意味する。 In the present specification, "to" in the numerical range is a range including numerical values before and after that, for example, "0 mass% to 100 mass%" is 0 mass% or more and 100 mass% or less. Means a range.
「閉塞力」は、水中油型乳化化粧料が有する皮膚表面からの水分蒸発を抑制する機能であり、後述する実施例に記載の閉塞性試験により評価及び確認できる。 "Occlusion force" is a function of an oil-in-water emulsion cosmetic to suppress water evaporation from the skin surface, and can be evaluated and confirmed by an occlusivity test described in Examples described later.
「使用感」は、水中油型乳化化粧料を皮膚へ塗布した際の皮膚へのなじみ、ぬるつき又はこれらの両方を意味する。また、「なじみ」は水中油型乳化化粧料を皮膚へ塗布した際に指止まり感が早くきて、いつまでも表面でヌルヌルしない感覚を意味し、「ぬるつき」は水中油型乳化化粧料を皮膚へ塗布した際の上滑りする感覚を意味する。「なじみ」は、後述する実施例に記載の使用感官能評価及び／又は摩擦試験により評価及び確認できる。「ぬるつき」は、後述する実施例に記載の使用感官能評価により評価及び確認できる。 "Feeling in use" means familiarity with the skin, slimyness, or both when the oil-in-water emulsion cosmetic is applied to the skin. In addition, "familiar" means that when applying the oil-in-water emulsion cosmetic to the skin, the feeling of stopping the fingers comes earlier, and the surface does not get slimy forever, and "lubricity" means that the oil-in-water emulsion cosmetic is applied to the skin. It means the feeling of slipping up when applied to. The "familiarity" can be evaluated and confirmed by a sensory evaluation on use feeling and/or a friction test described in Examples described later. The "sliminess" can be evaluated and confirmed by sensory evaluation of feeling of use described in Examples described later.
「（メタ）アクリル酸」は、アクリル酸及びメタクリル酸を包含する総称である。 “(Meth)acrylic acid” is a general term that includes acrylic acid and methacrylic acid.
本発明の一態様の水中油型乳化化粧料は、ワセリン、流動パラフィン、パラフィン、流動イソパラフィン、流動オゾケライト、プリスタン、スクワラン及び水素添加スクワランからなる群から選ばれる少なくとも１種の炭化水素系油性成分（成分（Ａ））と、高級脂肪酸（成分（Ｂ））と、高級アルコール（成分（Ｃ））と、少なくとも２個の長鎖疎水基及び少なくとも２個の親水基を分子内に有する多鎖多親水基型界面活性剤（成分（Ｄ））とを少なくとも含有する。 The oil-in-water emulsion cosmetic of one aspect of the present invention is at least one hydrocarbon-based oily component selected from the group consisting of petrolatum, liquid paraffin, paraffin, liquid isoparaffin, liquid ozokerite, pristane, squalane, and hydrogenated squalane ( Component (A)), higher fatty acid (component (B)), higher alcohol (component (C)), and a multi-chain poly-chain having at least two long-chain hydrophobic groups and at least two hydrophilic groups in the molecule. At least a hydrophilic group type surfactant (component (D)) is contained.
成分（Ａ）の炭化水素系油性成分は、ワセリン、流動パラフィン、パラフィン、流動イソパラフィン、流動オゾケライト、プリスタン、スクワラン及び水素添加スクワランからなる群から選ばれる。成分（Ａ）の炭化水素系油性成分は、上記列挙した中の１種、２種、３種、４種、５種、６種、７種又は８種全部の炭化水素系油性成分であれば特に限定されないが、ワセリン及び／又はスクワランを含むことが好ましい。 The hydrocarbon-based oil component of component (A) is selected from the group consisting of petrolatum, liquid paraffin, paraffin, liquid isoparaffin, liquid ozokerite, pristane, squalane and hydrogenated squalane. The hydrocarbon-based oily component of the component (A) is one, two, three, four, five, six, seven or eight hydrocarbon-based oily components listed above. Although it is not particularly limited, it preferably contains petrolatum and/or squalane.
成分（Ａ）の含有量は、閉塞力が発揮される量であれば特に限定されないが、例えば、１質量％以上であり、好ましくは５質量％以上であり、より好ましくは１０質量％以上である。上限は特に限定されないが、典型的には５０質量％以下である。成分（Ａ）の含有量がこれらの範囲内にあることにより、本発明の一態様の水中油型乳化化粧料は経時安定性に優れつつも、閉塞力を発揮して、塗布した皮膚表面からの水分蒸発を抑制することが可能になり、皮膚の水分バリア機能を改善又は維持することができる。 The content of the component (A) is not particularly limited as long as the blocking force is exerted, but is, for example, 1% by mass or more, preferably 5% by mass or more, more preferably 10% by mass or more. is there. The upper limit is not particularly limited, but it is typically 50% by mass or less. When the content of the component (A) is within these ranges, the oil-in-water emulsion cosmetic of one aspect of the present invention exhibits excellent aging stability, but also exerts an occluding force to remove the It is possible to suppress the evaporation of water from the skin and improve or maintain the water barrier function of the skin.
成分（Ｂ）の高級脂肪酸は、通常知られているとおりの炭素数が１２以上である直鎖又は分岐鎖のモノカルボン酸であれば特に限定されない。成分（Ｂ）は、成分（Ｃ）とともに、成分（Ａ）と成分（Ｄ）とを混合して予備乳化する際に生じる油浮きを回避するように機能する。 The higher fatty acid of the component (B) is not particularly limited as long as it is a linear or branched monocarboxylic acid having 12 or more carbon atoms as is commonly known. The component (B) functions to avoid oil floating that occurs when the component (C) and the component (A) and the component (D) are mixed and pre-emulsified together with the component (C).
成分（Ｂ）としては、例えば、ラウリン酸、ミリスチン酸、パルミチン酸、ステアリン酸、イソステアリン酸、ベヘン酸、ウンデシレン酸、１２−ヒドロキシステアリン酸、パルミトオレイン酸、オレイン酸、リノール酸、リノレイン酸、アラキドン酸、エルカ酸、ドコサヘキサエン酸、エイコサペンタエン酸、イソヘキサデカン酸、アンテイソヘンイコサン酸などが挙げられるが、これらに限定されない。成分（Ｂ）としては、化粧料の原料としての実績が豊富な、親油性の脂肪酸であるという観点から、炭素数が１２〜２０である高級脂肪酸が好ましく、ステアリン酸、ミリスチン酸及びパルミチン酸がより好ましい。 Examples of the component (B) include lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitooleic acid, oleic acid, linoleic acid, linoleic acid, Examples thereof include, but are not limited to, arachidonic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, and anteisohenicosanoic acid. As the component (B), a higher fatty acid having 12 to 20 carbon atoms is preferable, and stearic acid, myristic acid, and palmitic acid are preferable from the viewpoint of a lipophilic fatty acid that has a good track record as a raw material for cosmetics. More preferable.
成分（Ｂ）の含有量は、成分（Ｃ）とともに配合することにより、本発明の一態様の水中油型乳化化粧料の製造に際して予備乳化した後に生じ得る油浮きを回避し得る量であれば特に限定されないが、例えば、０．０１質量％〜１０質量％であり、好ましくは０．１質量％〜１質量％である。成分（Ｂ）の含有量が０．０１質量％未満又は１０質量％を超える場合、予備乳化後の油浮きを回避できないことや経時安定性が損なわれることなどの問題が生じ得る。ただし、成分（Ｂ）の含有量は、成分（Ａ）及び成分（Ｄ）の含有量によって適宜設定され得る。 The content of the component (B) is such that it can be mixed with the component (C) so as to avoid oil floating that may occur after pre-emulsification in the production of the oil-in-water emulsion cosmetic of one embodiment of the present invention. Although not particularly limited, it is, for example, 0.01% by mass to 10% by mass, preferably 0.1% by mass to 1% by mass. When the content of the component (B) is less than 0.01% by mass or more than 10% by mass, problems such as inability to avoid oil floating after pre-emulsification and impaired stability over time may occur. However, the content of the component (B) can be appropriately set depending on the content of the component (A) and the component (D).
成分（Ｃ）の高級アルコールは、通常知られているとおりの炭素数が６以上であるアルコールであれば特に限定されない。成分（Ｃ）は、成分（Ｂ）とともに、成分（Ａ）と成分（Ｄ）とを混合して予備乳化する際に生じる油浮きを回避するように機能する。 The higher alcohol as the component (C) is not particularly limited as long as it is an alcohol having a carbon number of 6 or more as is commonly known. The component (C) functions to avoid oil floating that occurs when the component (A) and the component (D) are mixed and pre-emulsified together with the component (B).
成分（Ｃ）としては、例えば、セタノール、ミリスチルアルコール、オレイルアルコール、ラウリルアルコール、セトステアリルアルコール、ステアリルアルコール、アラキルアルコール、ベヘニルアルコール、ホホバアルコール、キミルアルコール、セラキルアルコール、バチルアルコール、ヘキシルデカノール、イソステアリルアルコール、２−オクチルドデカノール、ダイマージオールなどが挙げられるが、これらに限定されない。成分（Ｃ）としては、化粧料の原料としての実績が豊富な親油性のアルコールであるという観点から、炭素数が６〜２０である高級アルコールが好ましく、セタノール、セトステアリルアルコール及びベヘニルアルコールがより好ましい。 Examples of the component (C) include cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, cerakil alcohol, batyl alcohol, hexyldecanol and iso. Examples include, but are not limited to, stearyl alcohol, 2-octyldodecanol, dimer diol, and the like. As the component (C), a higher alcohol having 6 to 20 carbon atoms is preferable, and cetanol, cetostearyl alcohol and behenyl alcohol are more preferable, from the viewpoint that it is a lipophilic alcohol which has a good track record as a raw material for cosmetics. ..
成分（Ｃ）の含有量は、成分（Ｂ）とともに配合することにより、本発明の一態様の水中油型乳化化粧料の製造に際して予備乳化した後に生じ得る油浮きを回避し得る量であれば特に限定されないが、例えば、０．０１質量％〜１０質量％であり、好ましくは０．１〜５質量％である。成分（Ｃ）の含有量が０．０１質量％未満又は１０質量％を超える場合、予備乳化後の油浮きを回避できないことや経時安定性が損なわれることなどの問題が生じ得る。ただし、成分（Ｃ）の含有量は、成分（Ａ）及び成分（Ｄ）の含有量によって適宜設定され得る。 The content of the component (C) is such that, when blended with the component (B), oil floating that may occur after pre-emulsification in the production of the oil-in-water emulsion cosmetic of one embodiment of the present invention can be avoided. Although not particularly limited, it is, for example, 0.01% by mass to 10% by mass, preferably 0.1% by mass to 5% by mass. When the content of the component (C) is less than 0.01% by mass or more than 10% by mass, problems such as inability to avoid oil floating after pre-emulsification and impaired stability over time may occur. However, the content of the component (C) can be appropriately set depending on the content of the component (A) and the component (D).
成分（Ｄ）の多鎖多親水基型界面活性剤は、少なくとも２個の長鎖疎水基及び少なくとも２個の親水基を分子内に有する。成分（Ｄ）は、少量であっても乳化力が強く、乳化粒子を保持する機能に優れており、本発明の一態様の水中油型乳化化粧料が皮膚へ塗布した際の良好な使用感を発揮するために機能する。 The multi-chain poly-hydrophilic group type surfactant of the component (D) has at least two long chain hydrophobic groups and at least two hydrophilic groups in the molecule. The component (D) has a strong emulsifying power even in a small amount and has an excellent function of holding emulsified particles, and has a good feeling of use when the oil-in-water emulsion cosmetic of one embodiment of the present invention is applied to the skin. Function to exert.
成分（Ｄ）における少なくとも２個の長鎖疎水基は、それぞれ独立して、直鎖、分岐鎖、環状鎖の炭化水素鎖を含む疎水基であれば特に限定されないが、例えば、炭素数が８個〜２０個の飽和又は不飽和の疎水基などを挙げることができ、好ましくは炭素数が８個〜２０個の飽和脂肪酸又は不飽和脂肪酸から誘導される長鎖アシル基である。少なくとも２個の長鎖疎水基は、それぞれが異なるものでも同一のものであってもよい。 The at least two long-chain hydrophobic groups in the component (D) are not particularly limited as long as they are independently hydrophobic groups containing a linear, branched, or cyclic hydrocarbon chain, and have, for example, 8 carbon atoms. 1 to 20 saturated or unsaturated hydrophobic groups can be mentioned, and a long-chain acyl group derived from a saturated fatty acid or unsaturated fatty acid having 8 to 20 carbon atoms is preferable. The at least two long-chain hydrophobic groups may be the same or different from each other.
成分（Ｄ）における少なくとも２個の親水基は、それぞれ独立して、例えば、カルボキシル基、スルホン酸基、硫酸残基、リン酸残基、アミノ基、４級アンモニウム基、ピリジニウム基、スルホニウム基及びそれらの塩など、オキシアルキレン基、ポリエチレングリコール基などを挙げることができる。塩は、例えば、アルカリ金属塩、アルカリ土類金属塩、アンモニウム塩、有機アミン塩、塩基性アミノ酸塩などを挙げることができる。 At least two hydrophilic groups in the component (D) are each independently, for example, a carboxyl group, a sulfonic acid group, a sulfuric acid residue, a phosphoric acid residue, an amino group, a quaternary ammonium group, a pyridinium group, a sulfonium group and Examples thereof include oxyalkylene groups and polyethylene glycol groups, such as salts thereof. Examples of the salt include alkali metal salts, alkaline earth metal salts, ammonium salts, organic amine salts, basic amino acid salts and the like.
成分（Ｄ）における長鎖疎水基及び親水基の数は、それぞれが２個以上であれば特に限定されず、それぞれが異なる数でも同一の数であってもよい。 The numbers of long-chain hydrophobic groups and hydrophilic groups in the component (D) are not particularly limited as long as each is 2 or more, and may be different numbers or the same numbers.
成分（Ｄ）の多鎖多親水基型界面活性剤は、分子内における長鎖疎水基及び親水基の種類並びに数が上記したものであれば特に限定されないが、例えば、エチレンジコカミドポリエチレングリコールジ硫酸２ナトリウム、ビス（カルボキシメチル）コハク酸ジラウリル、ジラウロイルグルタミン酸リシンナトリウムなどを挙げることができ、皮膚に対する良好な使用感及び皮膚への高い安全性の観点から、ジラウロイルグルタミン酸リシンナトリウムを含むものであることが好ましい。ジラウロイルグルタミン酸リシンナトリウムとしては、例えば、商品名「ペリセア（登録商標） Ｌ−３０」及び「ペリセア（登録商標） ＬＢ−１０」（それぞれ旭化成ファインケム株式会社製）として市販されているものなどを使用できる。 The multi-chain poly-hydrophilic group-type surfactant of the component (D) is not particularly limited as long as the type and number of long-chain hydrophobic groups and hydrophilic groups in the molecule are as described above, and examples thereof include ethylene dicocamide polyethylene glycol. Examples thereof include disodium disulfate, dilauryl bis(carboxymethyl)succinate, and sodium lysine dilauroylglutamate. From the viewpoint of good skin feel and high safety to the skin, lysine dilauroylglutamate is included. It is preferable that it is toxic. As dilauroyl glutamic acid lysine sodium, for example, those commercially available under the trade names “Perisea (registered trademark) L-30” and “Perisea (registered trademark) LB-10” (each manufactured by Asahi Kasei Finechem Co., Ltd.) are used. it can.
成分（Ｄ）の含有量は、成分（Ａ）を乳化して本発明の一態様の水中油型乳化化粧料において乳化粒子として保持し得る量であれば特に限定されないが、例えば、０．００１質量％〜５．０質量％であり、好ましくは０．００５質量％〜１．０質量％であり、より好ましくは０．０１質量％〜０．５質量％であり、さらに好ましくは０．０３質量％〜０．３質量％である。成分（Ｄ）の含有量が０．００１質量％より小さい場合は、本発明の一態様の水中油型乳化化粧料が閉塞力を発揮し得るだけの成分（Ａ）を配合できないおそれがある。また、成分（Ｄ）の含有量が５．０質量％より大きい場合は、本発明の一態様の水中油型乳化化粧料において皮膚刺激性の危険性が高まるので好ましくない。 The content of the component (D) is not particularly limited as long as the component (A) can be emulsified and held as emulsified particles in the oil-in-water emulsion cosmetic of one embodiment of the present invention, but, for example, 0.001 Mass% to 5.0 mass%, preferably 0.005 mass% to 1.0 mass%, more preferably 0.01 mass% to 0.5 mass%, still more preferably 0.03 mass%. It is from mass% to 0.3 mass %. When the content of the component (D) is less than 0.001% by mass, the oil-in-water emulsion cosmetic of one embodiment of the present invention may not be able to contain the component (A) sufficient to exert the blocking force. When the content of the component (D) is more than 5.0% by mass, the risk of skin irritation increases in the oil-in-water emulsion cosmetic of one embodiment of the present invention, which is not preferable.
また、成分（Ｄ）は、成分（Ａ）を乳化して本発明の一態様の水中油型乳化化粧料において乳化粒子として保持する機能を果たすことから、成分（Ｄ）の含有量は成分（Ａ）の含有量に影響する。成分（Ｄ）の含有量は、例えば、成分（Ａ）の含有量に対して（成分（Ｄ）／成分（Ａ））、０．００１〜０．１であり、好ましくは０．００５〜０．０５であり、より好ましくは０．００８〜０．０３である。 Further, since the component (D) has a function of emulsifying the component (A) and retaining it as emulsified particles in the oil-in-water emulsion cosmetic of one aspect of the present invention, the content of the component (D) is the component (D). Affects the content of A). The content of the component (D) is, for example, (component (D)/component (A)) with respect to the content of the component (A), 0.001 to 0.1, and preferably 0.005 to 0. 0.05, and more preferably 0.008 to 0.03.
本発明の一態様の水中油型乳化化粧料は、成分（Ａ）〜（Ｄ）を含有し、さらに乳化粒子のメディアン径（Ｄ５０）が１．０μｍ未満である微細エマルションであることにより、皮膚に対して良好な使用感を付与することができる。乳化粒子のメディアン径（Ｄ５０）が１．０μｍ以上であると、本発明の一態様の水中油型乳化化粧料の使用感や経時安定性が低下する傾向にある。 The oil-in-water emulsion cosmetic of one aspect of the present invention is a fine emulsion containing components (A) to (D) and further having a median diameter (D50) of the emulsified particles of less than 1.0 μm, so that the skin A good usability can be imparted to the. When the median diameter (D50) of the emulsified particles is 1.0 μm or more, the usability and temporal stability of the oil-in-water emulsion cosmetic of one embodiment of the present invention tend to be lowered.
乳化粒子のメディアン径（Ｄ５０）とは、水中油型乳化化粧料中に存在する乳化粒子の粒径を、小粒径側から積算した累計体積が５０％となるときの粒子径（μｍ）をいう。乳化粒子のメディアン径（Ｄ５０）の測定は、後述する実施例に記載があるとおりに、レーザー回折粒度分布計によって測定することができる。 The median diameter (D50) of the emulsified particles is the particle diameter (μm) when the cumulative volume of the particle diameters of the emulsified particles present in the oil-in-water emulsified cosmetic composition is 50% from the small particle diameter side. Say. The median diameter (D50) of the emulsified particles can be measured by a laser diffraction particle size distribution meter, as described in Examples described later.
本発明の一態様の水中油型乳化化粧料のｐＨは、通常知られているとおりの水中油型乳化化粧料のｐＨの範囲内であれば特に限定されないが、例えば、５〜９であり、好ましくは６〜８である。ｐＨの値が５〜９の範囲外にある場合は、経時安定性を維持することが困難になるおそれがある。 The pH of the oil-in-water emulsion cosmetic of one embodiment of the present invention is not particularly limited as long as it is within the range of the pH of the oil-in-water emulsion cosmetic that is generally known, but is, for example, 5 to 9, It is preferably 6 to 8. When the pH value is out of the range of 5 to 9, it may be difficult to maintain stability over time.
本発明の一態様の水中油型乳化化粧料は、本発明の課題を解決し得る限り、成分（Ａ）〜（Ｄ）に加えて、その他の成分を含有してもよい。 The oil-in-water emulsion cosmetic of one aspect of the present invention may contain other components in addition to the components (A) to (D) as long as the problem of the present invention can be solved.
その他の成分は特に限定されず、例えば、通常の水中油型乳化化粧料に用いられる成分などが挙げられ、より具体的には水などの基剤、成分（Ａ）以外の油性成分、保湿剤、清涼剤、防腐剤、キレート剤、ｐＨ調整剤、酸化防止剤、紫外線吸収剤、紫外線散乱剤、増粘剤、美白剤、ビタミン類、その他各種薬効成分、粉体、香料、色材などが挙げられる。その他の成分の含有量は、本発明の課題解決を妨げない限り、当業者により適宜設定し得る。その他の成分のいくつかについて以下に列挙するが、これらはあくまでも例示であり、限定されるものではない。 Other components are not particularly limited, and examples thereof include components used in ordinary oil-in-water emulsion cosmetics, and more specifically, bases such as water, oily components other than component (A), moisturizers. , Refreshing agents, antiseptics, chelating agents, pH adjusters, antioxidants, UV absorbers, UV scattering agents, thickeners, whitening agents, vitamins, other various medicinal ingredients, powders, fragrances, coloring materials, etc. Can be mentioned. The contents of other components can be appropriately set by those skilled in the art as long as they do not prevent the solution of the problems of the present invention. Some of the other components are listed below, but these are merely examples and are not limiting.
成分（Ａ）以外の油性成分は、例えば、油性エモリエント成分などが挙げられ、好ましくは水中油型乳化化粧料に通常用いられる室温（２５℃）で液体状又は半固形状である油性エモリエント成分である。成分（Ａ）以外の油性エモリエント成分の具体例としては、ジカプリン酸ネオペンチルグリコール、トリエチルヘキサノイン、パルミチン酸イソプロピル、２−エチルヘキサン酸セチル、イソノナン酸イソノニル、イソノナン酸イソトリデシル、セバシン酸ジイソプロピル、テトラ２−エチルヘキサン酸ペンタエリスリチル、コハク酸ジエチルヘキシル、炭素数１２〜１５のアルキルベンゾエートなどのエステル油；ジメチルポリシロキサン、ジメチルシクロポリシロキサン、メチルフェニルポリシロキサン、メチルハイドロジェンポリシロキサン、高級アルコール変性シリコーン油などのシリコーン油；アセトグリセリル、トリイソオクタン酸グリセリル、トリイソステアリン酸グリセリル、トリイソパルミチン酸グリセリル、モノステアリン酸グリセリル、ジ−２−ヘプチルウンデカン酸グリセリル、トリミリスチン酸グリセリルなどのグリセライド油；液状ラノリンなどの動物油；フルオロポリエーテル、パーフルオロアルキルエーテルシリコーンなどのフッ素油；オリーブ油、ホホバ油、ラベンダー油、月見草油、アボガド油、ツバキ油、タートル油、マカデミアナッツ油、トウモロコシ油、ミンク油、ナタネ油、卵黄油、ゴマ油、パーシック油、小麦胚芽油、サザンカ油、ヒマシ油、アマニ油、サフラワー油、綿実油、エノ油、大豆油、落花生油、茶実油、カヤ油、コメヌカ油、シナギリ油、日本キリ油、胚芽油などの天然油性成分などが挙げられるが、これらに限定されない。成分（Ａ）以外の油性エモリエント成分は、上記したものの１種を単独で、又は２種以上を組み合わせて使用することができる。成分（Ａ）以外の油性エモリエント成分の含有量は、０質量％〜１０質量％であることが好ましい。 Examples of the oily component other than the component (A) include an oily emollient component, and preferably an oily emollient component that is liquid or semi-solid at room temperature (25° C.) usually used for oil-in-water emulsion cosmetics. is there. Specific examples of the oily emollient components other than the component (A) include neopentyl glycol dicaprate, triethylhexanoin, isopropyl palmitate, cetyl 2-ethylhexanoate, isononyl isononanoate, isotridecyl isononanoate, diisopropyl sebacate, tetra 2 -Ester oil such as pentaerythrityl ethylhexanoate, diethylhexyl succinate, alkylbenzoate having 12 to 15 carbon atoms; dimethylpolysiloxane, dimethylcyclopolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, higher alcohol-modified silicone Silicone oils such as oils; glyceryl oils such as acetoglyceryl, glyceryl triisooctanoate, glyceryl triisostearate, glyceryl triisopalmitate, glyceryl monostearate, glyceryl di-2-heptylundecanoate, glyceryl trimyristate; liquid lanolin Animal oils such as; Fluoropolyether, Fluorine oils such as perfluoroalkyl ether silicones; Olive oil, jojoba oil, lavender oil, evening primrose oil, avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, rapeseed oil, Egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, teaseed oil, kaya oil, rice bran oil, cinnamon oil, Japan Examples include natural oily ingredients such as tung oil and germ oil, but are not limited thereto. As the oily emollient component other than the component (A), one type of those described above can be used alone, or two or more types can be used in combination. The content of the oily emollient component other than the component (A) is preferably 0% by mass to 10% by mass.
保湿剤としては、例えば、グリセリン、ジグリセリン、トレハロース、ブチレングリコール（ＢＧ）、キシリトール、マルチトール、マルトース、ソルビトール、ブドウ糖、果糖、加水分解エラスチン、乳酸ナトリウム、シクロデキストリン、ピロリドンカルボン酸などが挙げられ、これらの１種を単独で、又は２種以上を組み合わせて使用できる。保湿剤の含有量は、０質量％〜１５質量％であることが好ましい。 Examples of the moisturizer include glycerin, diglycerin, trehalose, butylene glycol (BG), xylitol, maltitol, maltose, sorbitol, glucose, fructose, hydrolyzed elastin, sodium lactate, cyclodextrin, pyrrolidonecarboxylic acid and the like. , These 1 type can be used individually or in combination of 2 or more types. The content of the moisturizer is preferably 0% by mass to 15% by mass.
防腐剤としては、例えば、安息香酸、サリチル酸、石炭酸、ソルビン酸、パラオキシ安息香酸メチル、パラクロルメタクレゾール、ヘキサクロロフェン、塩化ベンザルコニウム、塩化クロルヘキシジン、トリクロロカルバニリド、感光素、フェノキシエタノールなどが挙げられ、これらの１種を単独で、又は２種以上を組み合わせて使用できる。防腐剤の含有量は、０質量％〜１質量％であることが好ましい。 Examples of the preservatives include benzoic acid, salicylic acid, carboxylic acid, sorbic acid, methyl paraoxybenzoate, parachlorometacresol, hexachlorophene, benzalkonium chloride, chlorhexidine chloride, trichlorocarbanilide, photosensitizer, and phenoxyethanol. These can be used alone or in combination of two or more. The content of the preservative is preferably 0% by mass to 1% by mass.
ｐＨ調整剤としては、例えば、乳酸、クエン酸、グリコール酸、コハク酸、酒石酸、リンゴ酸、エチドロン酸、炭酸カリウム、炭酸水素ナトリウム、炭酸水素アンモニウム、水酸化ナトリウム、水酸化カリウム、トリエタノールアミン、モノエタノールアミンなどが挙げられ、これらの１種を単独で、又は２種以上を組み合わせて使用できる。ｐＨ調整剤の含有量は、０質量％〜１質量％であることが好ましい。 Examples of the pH adjuster include lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, etidronic acid, potassium carbonate, sodium hydrogen carbonate, ammonium hydrogen carbonate, sodium hydroxide, potassium hydroxide, triethanolamine, Monoethanolamine etc. are mentioned, These 1 type can be used individually or in combination of 2 or more types. The content of the pH adjuster is preferably 0% by mass to 1% by mass.
酸化防止剤としては、例えば、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、δトコフェロールなどのビタミンＥ及びその誘導体；チオタウリン、メマツヨイグサ抽出液、βカロチン、カテキン化合物、フラボノイド化合物、ポリフェノール化合物などが挙げられ、これらの１種を単独で、又は２種以上を組み合わせて使用できる。酸化防止剤の含有量は、０質量％〜１質量％であることが好ましい。 Examples of the antioxidant include vitamin E and its derivatives such as dibutylhydroxytoluene, butylhydroxyanisole, and δ-tocopherol; thiotaurine, evening primrose extract, β-carotene, catechin compounds, flavonoid compounds, polyphenol compounds, and the like. They may be used alone or in combination of two or more. The content of the antioxidant is preferably 0% by mass to 1% by mass.
増粘剤としては、例えば、ヒアルロン酸、ヒアルロン酸ナトリウム、アセチル化ヒアルロン酸、アセチル化ヒアルロン酸ナトリウム、コンドロイチン硫酸、コンドロイチン硫酸ナトリウム、フコイダン、チューベロース多糖体、キサンタンガムなどの水溶性多糖類；カラギーナン、アルギン酸などの天然高分子；カルボキシメチルセルロースナトリウムなどの半合成高分子；カルボマー、ポリアクリル酸、ポリアクリル酸ナトリウム、（メタ）アクリル酸／（メタ）アクリル酸アルキル共重合体などのアクリル酸系ポリマーなどの合成高分子などが挙げられる。カルボマーは、例えば、商品として「カーボポール９８０」、「カーボポール９１０」、「カーボポール９３４」、「カーボポール９４０」、「カーボポール９４１」、「カーボポール９８１」（それぞれＬｕｂｒｉｚｏｌ Ａｄｖａｎｃｅｄ Ｍａｔｅｒｉａｌｓ，Ｉｎｃ．製）などとして市販されている。（メタ）アクリル酸／（メタ）アクリル酸アルキル共重合体は、例えば、「カーボポールＳＣ−５００」、「カーボポール１３８２」、「カーボポールＥＴＤ２０２０」、「ＰＥＭＵＬＥＮ ＴＲ−１」、「ＰＥＭＵＬＥＮ ＴＲ−２」（それぞれＬｕｂｒｉｚｏｌ Ａｄｖａｎｃｅｄ Ｍａｔｅｒｉａｌｓ，Ｉｎｃ．製）などとして市販されている。カルボキシメチルセルロースナトリウムは、例えば、商品として「ＣＭＣダイセル」（ダイセル化学工業株式会社製）などとして市販されている。増粘剤は、これらの１種を単独で、又は２種以上を組み合わせて使用できる。増粘剤の含有量は、０質量％〜１質量％であることが好ましい。 Examples of the thickener include water-soluble polysaccharides such as hyaluronic acid, sodium hyaluronate, acetylated hyaluronic acid, sodium acetylated hyaluronate, chondroitin sulfate, sodium chondroitin sulfate, fucoidan, tuberose polysaccharide, xanthan gum; carrageenan, alginic acid. Such as natural polymers; semi-synthetic polymers such as sodium carboxymethyl cellulose; carbomer, polyacrylic acid, sodium polyacrylate, acrylic acid-based polymers such as (meth)acrylic acid/alkyl (meth)acrylate copolymers, etc. Examples include synthetic polymers. Carbomer is commercially available, for example, as "Carbopol 980", "Carbopol 910", "Carbopol 934", "Carbopol 940", "Carbopol 941", and "Carbopol 981" (Lubrizol Advanced Materials, Inc., respectively). (Made by the manufacturer). The (meth)acrylic acid/alkyl (meth)acrylate copolymer is, for example, "Carbopol SC-500", "Carbopol 1382", "Carbopol ETD2020", "PEMULEN TR-1", "PEMULEN TR-". 2" (each manufactured by Lubrizol Advanced Materials, Inc.) and the like. Carboxymethylcellulose sodium is commercially available as, for example, "CMC Daicel" (manufactured by Daicel Chemical Industries, Ltd.). These thickeners may be used alone or in combination of two or more. The content of the thickener is preferably 0% by mass to 1% by mass.
本発明の一態様の水中油型乳化化粧料は、化粧料として用いられる限りにおいて、その機能や効果については特に限定されない。本発明の一態様の水中油型乳化化粧料は、閉塞力について、例えば、後述する実施例に記載の閉塞性試験により、水分蒸発抑制率が１０％以上であり、優れた閉塞力を有するという観点では、水分蒸発抑制率が２０％以上であることが好ましく、３０％以上であることがより好ましい。水分蒸発抑制率の上限は特に限定されず、典型的には９０％程度である。 The oil-in-water emulsified cosmetic of one aspect of the present invention is not particularly limited in its function and effect as long as it is used as a cosmetic. The oil-in-water emulsified cosmetic of one aspect of the present invention is said to have an excellent clogging force with respect to the clogging force, for example, a moisture evaporation suppression rate of 10% or more, according to a clogging test described in Examples described later. From the viewpoint, the moisture evaporation suppression rate is preferably 20% or more, and more preferably 30% or more. The upper limit of the moisture evaporation suppression rate is not particularly limited and is typically about 90%.
本発明の一態様の水中油型乳化化粧料は、経時安定性について、例えば、後述する実施例に記載の経時安定性試験により、水相と油相との間の相分離や油浮きが認められない程度であることが好ましい。 The oil-in-water emulsified cosmetic of one aspect of the present invention is, for stability over time, for example, a time-dependent stability test described in Examples described later, phase separation between the aqueous phase and the oil phase and oil floating are observed. It is preferable that it is not possible.
本発明の一態様の水中油型乳化化粧料は、使用感について、例えば、後述する実施例に記載の「なじみ」に関する使用感評価により、パネラー間の平均点が３．５以上である。本発明の一態様の水中油型乳化化粧料は、使用感のうち、皮膚へのなじみが優れていることに特徴がある。 Regarding the feeling of use, the oil-in-water emulsion cosmetic of one aspect of the present invention has an average score of 3.5 or more between the panelists, for example, according to the feeling of use evaluation regarding "familiarity" described in Examples described later. The oil-in-water type emulsion cosmetic of one aspect of the present invention is characterized in that it is excellent in familiarity with the skin in terms of use feeling.
本発明の一態様の水中油型乳化化粧料のより具体的な態様は、成分（Ａ）を５質量％〜２０質量％、成分（Ｂ）を０．０５質量％〜０．２５質量％、成分（Ｃ）を０．５質量％〜２．０質量％及び成分（Ｄ）を０．０５質量％〜０．２０質量％で含有し、かつ、乳化粒子のメディアン径（Ｄ５０）が０．０１〜０．５０μｍであることにより、閉塞力が認められつつも、使用感及び経時安定性が良好である水中油型乳化化粧料であるが、これに限定されない。 A more specific aspect of the oil-in-water emulsion cosmetic of one aspect of the present invention is that the component (A) is 5% by mass to 20% by mass, the component (B) is 0.05% by mass to 0.25% by mass, The content of the component (C) is 0.5 mass% to 2.0 mass% and the content of the component (D) is 0.05 mass% to 0.20 mass%, and the median diameter (D50) of the emulsified particles is 0. When it is from 01 to 0.50 μm, it is an oil-in-water type emulsion cosmetic having a good feeling in use and stability over time, although the blocking force is recognized, but the invention is not limited thereto.
本発明の一態様の水中油型乳化化粧料は、成分（Ａ）〜成分（Ｄ）を高速撹拌処理及び高圧ホモジナイズ処理の双方に供して乳化することにより得られる。本発明の別の一態様は、本発明の一態様の水中油型乳化化粧料の製造方法である。本発明の一態様の製造方法は、成分（Ａ）〜成分（Ｄ）を高速撹拌処理に供して予備乳化液を得る工程；及び予備乳化液を高圧ホモジナイズ処理に供して、本発明の一態様の水中油型乳化化粧料を得る工程を少なくとも含む。高速撹拌処理及び高圧ホモジナイズ処理のいずれか一方のみによる乳化では、経時安定性及び／又は使用感に優れた微細エマルション組成物を得ることができない。 The oil-in-water emulsion cosmetic of one aspect of the present invention is obtained by subjecting the components (A) to (D) to both high-speed stirring treatment and high-pressure homogenization treatment to emulsify. Another aspect of the present invention is a method for producing an oil-in-water emulsion cosmetic of one aspect of the present invention. The production method according to one aspect of the present invention comprises subjecting the components (A) to (D) to high-speed agitation treatment to obtain a preliminary emulsion, and subjecting the preliminary emulsion to a high-pressure homogenization treatment to obtain one embodiment of the present invention. At least including the step of obtaining the oil-in-water emulsion cosmetic. Emulsification by only one of the high-speed stirring treatment and the high-pressure homogenization treatment cannot give a fine emulsion composition excellent in stability over time and/or feeling in use.
本発明の一態様の製造方法の具体例としては、それぞれ６０℃〜８０℃に加温した成分（Ａ）〜成分（Ｃ）及びその他の親油性成分の混合物と成分（Ｄ）及びその他の親水性成分の混合物とを、高速撹拌機を用いて、３，０００ｒｐｍ〜８，０００ｒｐｍ、数分間高速撹拌処理に供して予備乳化液を得て、次いで得られた予備乳化液を、５０℃程度に冷却した後、高圧乳化機を用いて、高圧ホモジナイズ処理に供して高圧乳化液として本発明の一態様の水中油型乳化化粧料を得る方法などが挙げられるが、これに限定されない。高圧ホモジナイズ処理のその他の条件は、乳化粒子のメディアン径（Ｄ５０）が１．０μｍ未満である高圧乳化液を得られるような条件であればよい。上記のようにして得られた高圧乳化液に、増粘剤、保湿剤、防腐剤などのその他の成分を混合したものを、本発明の一態様の水中油型乳化化粧料としてもよい。 Specific examples of the production method of one embodiment of the present invention include a mixture of component (A) to component (C) and another lipophilic component heated to 60° C. to 80° C. and component (D) and other hydrophilic components. Using a high-speed stirrer, the mixture of the sex components is subjected to high-speed stirring treatment at 3,000 rpm to 8,000 rpm for several minutes to obtain a preliminary emulsion, and the obtained preliminary emulsion is then heated to about 50°C. After cooling, it may be subjected to a high-pressure homogenization treatment using a high-pressure emulsifying machine to obtain the oil-in-water emulsion cosmetic of one embodiment of the present invention as a high-pressure emulsion, but the method is not limited thereto. Other conditions for the high-pressure homogenization treatment may be such that a high-pressure emulsion having a median diameter (D50) of the emulsified particles of less than 1.0 μm can be obtained. A mixture of the high-pressure emulsion obtained as described above and other components such as a thickener, a moisturizer, and a preservative may be used as the oil-in-water emulsion cosmetic of one embodiment of the present invention.
成分（Ａ）及び成分（Ｄ）に加えて、成分（Ｂ）及び成分（Ｃ）を配合することにより、これらを高速撹拌処理に供して得られる予備乳化液を、室温において数日間程度は油浮きを抑制して維持することができる。したがって、本発明の別の一態様は、成分（Ａ）〜成分（Ｄ）を高速撹拌処理に供して予備乳化液を得る工程を少なくとも含む、予備乳化液の油浮きを抑制する方法である。 By adding the component (B) and the component (C) in addition to the component (A) and the component (D), the preliminary emulsion obtained by subjecting them to a high-speed stirring treatment is used as an oil for about several days at room temperature. Floating can be suppressed and maintained. Therefore, another aspect of the present invention is a method of suppressing oil floating of a preliminary emulsion, which comprises at least a step of subjecting components (A) to (D) to a high-speed stirring treatment to obtain a preliminary emulsion.
本発明の一態様の水中油型乳化化粧料は、その使用態様や剤形については特に限定されず、例えば、スキンケア化粧品、メーキャップ化粧品、フレグランス化粧品、ボディケア化粧品などが挙げられ、より具体的にはクリーム、乳液、ファンデーション、化粧水、美容液、サンスクリーンジェル、ローション、パック、洗顔クリーム、ハンドクリーム、メーキャップクレンジング、化粧下地、コンシーラー、ほほ紅、アイシャドウ、アイライナー、アイブロウ、口紅、日焼け止めクリーム、脱毛・除毛クリーム、オールインワン化粧品などが挙げられる。本発明の一態様の水中油型乳化化粧料は、ジェル、乳液、ローション、クリームなどの一定の粘性を有する剤形とすることにより、安定性に優れ、さらにしっとりとした良好な使用感触を有し得るものとなることから好ましい。 The oil-in-water emulsified cosmetic of one aspect of the present invention is not particularly limited in terms of usage and dosage form, and examples thereof include skin care cosmetics, makeup cosmetics, fragrance cosmetics, body care cosmetics, and more specifically. Is cream, milky lotion, foundation, lotion, beauty essence, sunscreen gel, lotion, pack, face wash cream, hand cream, makeup cleansing, makeup base, concealer, blusher, eye shadow, eyeliner, eyebrow, lipstick, sunscreen Examples include creams, depilatory/hair removal creams, and all-in-one cosmetics. The oil-in-water emulsified cosmetic of one aspect of the present invention has excellent stability and further has a moist and good feeling when used in the form of gel, emulsion, lotion, cream and the like having a certain viscosity. It is preferable because it is possible.
本発明の一態様の水中油型乳化化粧料は、皮膚に塗布することで、皮膚表面からの水分蒸発を防ぐことが可能になることから、皮膚用水中油型乳化化粧料であることが好ましい。また、本発明の一態様の水中油型乳化化粧料は、水分及び保湿剤を含有することにより、塗布した乾燥皮膚を改善すること又はさらなる乾燥による悪化を抑制することが可能である。 The oil-in-water emulsion cosmetic of one aspect of the present invention is preferably an oil-in-water emulsion cosmetic for skin because it can prevent water evaporation from the skin surface when applied to the skin. In addition, the oil-in-water emulsion cosmetic of one aspect of the present invention can improve the dry skin to which it is applied or suppress further deterioration due to drying by containing water and a moisturizing agent.
以下、本発明を実施例によってさらに具体的に説明するが、本発明はこれら実施例に限定されるものではなく、本発明の課題を解決し得る限り、本発明は種々の態様をとることができる。 Hereinafter, the present invention will be described more specifically by way of examples, but the present invention is not limited to these examples, and the present invention can take various aspects as long as the problems of the present invention can be solved. it can.
［１．被験試料の調製］
（１−１）実施例１〜実施例１５の水中油型乳化化粧料
表１Ａに示した処方に従い、以下の手順により、実施例１〜実施例１５の水中油型乳化化粧料を調製した。なお、表中の数値は、質量％（ｗｔ％）を表わす。
[1. Preparation of test sample]
(1-1) Oil-in-water emulsified cosmetics of Examples 1 to 15 The oil-in-water emulsified cosmetics of Examples 1 to 15 were prepared by the following procedures according to the formulations shown in Table 1A. The numerical values in the table represent mass% (wt%).
表中のＡ相、Ｂ相及びＣ相のそれぞれについて、各成分を溶解混合することにより調製した。次いで、Ａ相及びＢ相を７０℃に加温した後、Ａ相をＢ相に投入して、５,０００ｒｐｍ、５分間ホモミキサー（「ラボ・リューション」；プライミクス株式会社製）を用いて高速撹拌処理に供することにより予備乳化液を得た。 It prepared by melt-mixing each component about each of A phase, B phase, and C phase in a table|surface. Then, after heating the A phase and the B phase to 70° C., the A phase is added to the B phase and the mixture is mixed with a homomixer (“Lab Solution”; manufactured by Primex Co., Ltd.) at 5,000 rpm for 5 minutes. A preliminary emulsion was obtained by subjecting the mixture to high-speed stirring treatment.
得られた予備乳化液を、５０℃に冷却した後、圧力を１７０ＭＰａ×３Ｐａｓｓ、背圧を３ＭＰａにして、高圧乳化機（高圧ホモジナイザー）（「スターバースト ミニ」；株式会社スギノマシン製）を用いて高圧ホモジナイズ処理に供することにより、高圧乳化液を得た。次いで、得られた高圧乳化液に、Ｃ相を添加して混合することにより、実施例１〜実施例１５の水中油型乳化化粧料を調製した。 The obtained preliminary emulsion was cooled to 50° C., the pressure was 170 MPa×3 Pass, the back pressure was 3 MPa, and a high pressure emulsifier (high pressure homogenizer) (“Starburst mini”; manufactured by Sugino Machine Ltd.) was used. And subjected to high pressure homogenization treatment to obtain a high pressure emulsion. Next, the oil-in-water emulsion cosmetics of Examples 1 to 15 were prepared by adding phase C to the obtained high-pressure emulsion and mixing.
（１−２）比較例１〜比較例７の水中油型乳化化粧料
表１Ｂに示した処方に従い、上記（１−１）と同様にして、Ａ相、Ｂ相及びＣ相をそれぞれ調製した後、Ａ相をＢ相に投入して、ホモミキサーを用いて高速撹拌処理に供して予備乳化液を得た。
(1-2) Oil-in-water emulsified cosmetics of Comparative Examples 1 to 7 According to the formulations shown in Table 1B, A phase, B phase and C phase were prepared in the same manner as in (1-1) above. Then, the phase A was added to the phase B, and the mixture was subjected to high-speed stirring treatment using a homomixer to obtain a preliminary emulsion.
得られた予備乳化液に、Ｃ相を添加して混合することにより、比較例１〜比較例７の水中油型乳化化粧料を調製した。 The oil-in-water emulsion cosmetics of Comparative Examples 1 to 7 were prepared by adding phase C to the obtained preliminary emulsion and mixing them.
（１−３）参考例１〜参考例５の溶液
表１Ｂに示した処方に従い、上記（１−１）と同様にして、Ａ相及びＢ相をそれぞれ調製した後、Ａ相をＢ相に投入して、ホモミキサーを用いて乳化処理に供した。しかし、得られた乳化処理後の溶液において、乳化が認められず、相分離が認められた。
(1-3) Solutions of Reference Examples 1 to 5 According to the formulations shown in Table 1B, the A phase and the B phase were respectively prepared in the same manner as in the above (1-1), and then the A phase was changed to the B phase. It was charged and subjected to emulsification treatment using a homomixer. However, in the obtained solution after the emulsification treatment, no emulsification was observed and phase separation was observed.
※１ 表中の「３０％ジラウロイルグルタミン酸リシンナトリウム」としては、「ペリセア（登録商標）Ｌ−３０」（旭化成ファインケム株式会社製）を用いた。
※２ 表中の「カルボマー」としては、「カーボポール９８０」（Ｌｕｂｒｉｚｏｌ Ａｄｖａｎｃｅｄ Ｍａｔｅｒｉａｌｓ，Ｉｎｃ．製）を用いた。
※３ 表中の「（アクリレーツ／アクリル酸アルキル（Ｃ１０−３０））クロスポリマー」としては、「カーボポールＳＣ−５００」（Ｌｕｂｒｉｚｏｌ Ａｄｖａｎｃｅｄ Ｍａｔｅｒｉａｌｓ，Ｉｎｃ．製）を用いた。
*1 "Pericea (registered trademark) L-30" (manufactured by Asahi Kasei Finechem Co., Ltd.) was used as "30% lysine sodium dilauroylglutamate" in the table.
*2 As the “carbomer” in the table, “Carbopol 980” (manufactured by Lubrizol Advanced Materials, Inc.) was used.
*3 "Carbopol SC-500" (manufactured by Lubrizol Advanced Materials, Inc.) was used as "(Acrylates/alkyl acrylate (C10-30)) crosspolymer" in the table.
［２．評価方法］
（２−１）粒子径測定
被験試料を精製水で希釈し、レーザー回折粒度分布計（「ＳＡＬＤ−２０００」；株式会社島津製作所製）を用いて、屈折率１．６０−０．１０ｉにて乳化粒子のメディアン径（Ｄ５０）を測定した。ただし、比較例１〜３の水中油型乳化化粧料については、顕微鏡観察によって、目視により、乳化粒子の粒子径が１〜５０μｍの範囲内にあることを確認した。
[2. Evaluation methods]
(2-1) Particle size measurement A test sample was diluted with purified water and a laser diffraction particle size distribution meter ("SALD-2000"; manufactured by Shimadzu Corporation) was used to obtain a refractive index of 1.60-0.10i. The median diameter (D50) of the emulsified particles was measured. However, for the oil-in-water emulsion cosmetics of Comparative Examples 1 to 3, it was confirmed by visual observation with a microscope that the particle size of the emulsified particles was within the range of 1 to 50 μm.
（２−２）経時安定性試験
規格ビンに被験試料を充填し、４５℃で１ヵ月保管した後、目視にて分離の有無を確認した。
(2-2) Time Stability Test A test sample was filled in a standard bottle and stored at 45° C. for 1 month, and then the presence or absence of separation was visually confirmed.
（２−３）使用感評価
（２−３−１）「なじみ」の評価
実施例１〜８及び比較例１〜７の水中油型乳化化粧料については、訓練を受けたパネラー５名を対象として、被験試料を直接的に皮膚へ塗布することにより、比較例１の水中油型乳化化粧料を対照として、皮膚への「なじみ」を下記の基準により点数をつけてパネラー間の平均点及び標準偏差を求めた。また、パネラー間の平均点が３．５以上であるものを「○」とし、パネラー間の平均点が３．５未満であり、かつ、パネラー１名以上が２以下の点数をつけたものを「×」として評価した。また、実施例９〜１５の水中油型乳化化粧料については、訓練を受けたパネラー１名を対象として、被験試料を直接的に皮膚へ塗布することにより、比較例１の水中油型乳化化粧料と比べてなじみが良いものを「○」とし、比較例１の水中油型乳化化粧料と比べてなじみが同等又は悪いものを「×」として評価した。
「なじみ」の基準：
５ 比較例１の水中油型乳化化粧料と比べて、非常になじみが良い
４ 比較例１の水中油型乳化化粧料と比べて、なじみが良い
３ 比較例１の水中油型乳化化粧料と同等のなじみ
２ 比較例１の水中油型乳化化粧料と比べて、なじみが悪い
１ 比較例１の水中油型乳化化粧料と比べて、非常になじみが悪い
(2-3) Evaluation of Usability (2-3-1) Evaluation of “Familiarity” For the oil-in-water emulsion cosmetics of Examples 1-8 and Comparative Examples 1-7, 5 trained panelists were targeted. As a test sample, by directly applying the test sample to the skin, the oil-in-water emulsified cosmetic composition of Comparative Example 1 was used as a control, and "familiarity" to the skin was scored according to the following criteria and the average score between the panelists The standard deviation was calculated. In addition, those with an average score between panelists of 3.5 or more are marked as "○", those with an average score of less than 3.5 and one or more panelists with a score of 2 or less. It was evaluated as "x". Regarding the oil-in-water emulsion cosmetics of Examples 9 to 15, the oil-in-water emulsion cosmetic of Comparative Example 1 was prepared by directly applying a test sample to one trained panelist. Those that were more familiar than the cosmetics were evaluated as “◯”, and those that were equivalent to or worse than the oil-in-water emulsion cosmetic of Comparative Example 1 were evaluated as “x”.
“Familiar” criteria:
5 Very good compatibility with the oil-in-water emulsion cosmetic of Comparative Example 1 4 Good compatibility with the oil-in-water emulsion cosmetic of Comparative Example 1 3 With the oil-in-water emulsion cosmetic of Comparative Example 1 Equivalent familiarity 2 Compared with the oil-in-water emulsion cosmetic of Comparative Example 1, it is poorly familiar 1 Compared with the oil-in-water emulsion cosmetic of Comparative Example 1, it is very incompatible
（２−３−２）「ぬるつき」の評価
実施例１〜１５及び比較例１〜７の水中油型乳化化粧料について、訓練を受けたパネラー１名を対象として、被験試料を直接的に皮膚へ塗布することにより、比較例１の水中油型乳化化粧料を対照として、皮膚への「ぬるつき」を下記の基準により評価した。
「ぬるつき」の基準：
○ 比較例１の水中油型乳化化粧料と比べて、ぬるつきを感じない
× 比較例１の水中油型乳化化粧料と比べて、ぬるつきを感じる
(2-3-2) Evaluation of "lubricity" Regarding the oil-in-water emulsion cosmetics of Examples 1 to 15 and Comparative Examples 1 to 7, the test sample was directly applied to one trained panelist. When applied to the skin, the oil-in-water emulsified cosmetic of Comparative Example 1 was used as a control, and the "lubricity" to the skin was evaluated according to the following criteria.
Criteria for sliminess:
○ It does not feel slimy as compared with the oil-in-water emulsion cosmetic of Comparative Example 1 × feels slimy as compared with the oil-in-water emulsion cosmetic of Comparative Example 1
（２−３−３）総合評価
「なじみ」及び「ぬるつき」がともに「○」として評価したものを使用感の総合評価として「○」とし、少なくともいずれか一方を「×」として評価したものを使用感の総合評価として「×」とした。
(2-3-3) Comprehensive evaluation When "familiar" and "slimy" were both evaluated as "○", the overall evaluation of the feeling of use was evaluated as "○", and at least one of them was evaluated as "x". Was evaluated as “x” as a comprehensive evaluation of the feeling of use.
（２−４）摩擦試験
使用感で確認した項目「なじみ」について客観的に数値評価するために、被験試料を塗布した際の摩擦係数の挙動を次の方法により確認した。
(2-4) Friction test In order to perform an objective numerical evaluation of the item "familiarity" confirmed by the feeling of use, the behavior of the friction coefficient when the test sample was applied was confirmed by the following method.
特願２０１７−１９３８２４号明細書に記載の摩擦試験機（触覚計測装置）の測定部位である摩擦面に被験試料を塗布し、荷重を０．５Ｎ、塗布速度を１０ｍｍ／ｓ、往復回数を５０回として、塗擦した。塗擦中の摩擦係数の変化を確認した。 The test sample is applied to the friction surface, which is the measurement site of the friction tester (tactile measurement device) described in Japanese Patent Application No. 2017-193824, and the load is 0.5 N, the application speed is 10 mm/s, and the number of reciprocations is 50. It was rubbed as a turn. The change in the friction coefficient during rubbing was confirmed.
（２−５）閉塞性試験
フィルター（「ＪＨＷＰ０４７００ Ｏｍｎｉｐｏｒｅ ｄｉｓｃ ＰＴＦＥ ｐｈｉｌｉｃ ０．４５μｍ」；メルク株式会社製）に被験試料を１００μｍの厚さに均一に塗布し、一晩室温で自然乾燥させた。規格ビンに精製水１５．００ｇを量りとり、ビンの口にフィルターを乗せて密栓状態にして固定し、室温で静置した。静置後の規格ビン内の精製水の量を測定し、水分蒸発抑制率を下記式により算出した。なお、フィルターに被験試料を塗布せずに試験したときの精製水の量をブランクとした。
水分蒸発抑制率（％）＝（ブランクの水分蒸発量−サンプルの水分蒸発量）／ブランクの水分蒸発量×１００
(2-5) A test sample was uniformly applied to a occlusivity test filter (“JHWP04700 Omnipore disc PTFE phili 0.45 μm”; manufactured by Merck Ltd.) to a thickness of 100 μm, and naturally dried overnight at room temperature. 15.00 g of purified water was weighed into a standard bottle, and a filter was placed on the mouth of the bottle to fix the bottle in a sealed stopper, and the bottle was allowed to stand at room temperature. The amount of purified water in the standard bottle after standing was measured, and the water evaporation suppression rate was calculated by the following formula. The amount of purified water used in the test without applying the test sample to the filter was used as a blank.
Moisture evaporation suppression rate (%) = (water evaporation amount of blank-water evaporation amount of sample)/water evaporation amount of blank x 100
（２−６）保水性試験
ろ紙（「ＡＤＶＡＮＴＥＣ Ｎｏ．５Ａ」；ＡＤＶＡＮＴＥＣ製）に５００μｍの厚みで被験試料を塗布し、デシケーター内で６時間にて静置した。静置後の被験試料の量から算出した水分蒸発率により保水性を評価した。
(2-6) Water retention test A test sample was applied to a filter paper (“ADVANTEC No. 5A”; manufactured by ADVANTEC) with a thickness of 500 μm and left standing in a desiccator for 6 hours. Water retention was evaluated by the water evaporation rate calculated from the amount of the test sample after standing.
（２−７）保湿力試験
被験者の前腕内側に被験試料を１ｍｇ／ｃｍ２で塗布し、塗布後の角層水分量をコルネオメーター（「Ｃｏｒｎｅｏｍｅｔｅｒ ＣＭ８２５」；Ｃｏｕｒａｇｅ＋Ｋｈａｚａｋａ社製）で測定した。水分変化率（％）を、塗布前の水分量に対し、塗布後６０〜９０分後の水分変化量（平均）にて算出した水分変化率により保湿力を評価した。
(2-7) Moisture retention test A test sample was applied to the inside of the forearm of the subject at 1 mg/cm 2 , and the amount of water in the stratum corneum after application was measured with a corneometer (“Corneometer CM825”; manufactured by Courage+Khazaka). The moisture change rate (%) was evaluated by the moisture change rate calculated from the moisture change rate (average) 60 to 90 minutes after application with respect to the water content before application.
［３．評価結果］
（３−１）粒子径、経時安定性、使用感、ｐＨ及び摩擦試験
実施例１〜実施例１５の水中油型乳化化粧料及び比較例１〜比較例７の水中油型乳化化粧料について、粒子径、経時安定性及び使用感を測定した結果を表１Ａ及び表１Ｂに示す。なお、ｐＨは、常法に従ってｐＨメーター（「ｐＨ ＭＥＴＥＲ Ｆ−２２」；株式会社堀場製作所製）を使用して測定した。
[3. Evaluation results]
(3-1) Particle size, stability over time, feeling of use, pH and friction test Regarding the oil-in-water emulsion cosmetics of Examples 1 to 15 and the oil-in-water emulsion cosmetics of Comparative Examples 1 to 7, The results of measuring the particle size, stability over time, and feeling during use are shown in Tables 1A and 1B. The pH was measured according to a conventional method using a pH meter (“pH METER F-22”; manufactured by Horiba Ltd.).
実施例１〜実施例１５の水中油型乳化化粧料及び比較例１〜比較例７の水中油型乳化化粧料は、いずれにおいても製造過程において油相及び水相の分離が認められないものであった。 In each of the oil-in-water emulsion cosmetics of Examples 1 to 15 and the oil-in-water emulsion cosmetics of Comparative Examples 1 to 7, separation of the oil phase and the water phase was not observed in the production process. there were.
表１Ａが示すとおり、実施例１〜実施例１５の水中油型乳化化粧料は、乳化粒子のメディアン径（Ｄ５０）が０．０６７〜０．４６２μｍの範囲内にあった。それに対して、表１Ｂが示すとおり、比較例１〜比較例３の水中油型乳化化粧料については乳化粒子の粒子径が１〜５０μｍの範囲内にあり、比較例４〜比較例７の水中油型乳化化粧料については乳化粒子のメディアン径（Ｄ５０）が１〜５０μｍの範囲内にあった。このように、実施例１〜実施例１５の水中油型乳化化粧料は、比較例１〜比較例７の水中油型乳化化粧料に比べて、乳化粒子のメディアン径（Ｄ５０）がより小さいものであった。 As shown in Table 1A, in the oil-in-water emulsion cosmetics of Examples 1 to 15, the median diameter (D50) of the emulsified particles was in the range of 0.067 to 0.462 μm. On the other hand, as shown in Table 1B, for the oil-in-water emulsion cosmetics of Comparative Examples 1 to 3, the particle size of the emulsified particles was within the range of 1 to 50 μm, and the water of Comparative Examples 4 to 7 was used. Regarding the oil-based emulsified cosmetics, the median diameter (D50) of the emulsified particles was within the range of 1 to 50 μm. As described above, the oil-in-water emulsion cosmetics of Examples 1 to 15 have smaller median diameters (D50) of the emulsified particles than the oil-in-water emulsion cosmetics of Comparative Examples 1 to 7. Met.
また、表１Ａ及び表１Ｂが示すとおり、実施例１〜実施例８の水中油型乳化化粧料は、いずれのものも経時安定性に優れていたが、比較例１〜比較例７の水中油型乳化化粧料の中には経時安定性の悪いものが見られた。 Further, as shown in Table 1A and Table 1B, all of the oil-in-water emulsion cosmetics of Examples 1 to 8 were excellent in stability over time, but the oil-in-water of Comparative Examples 1 to 7 was excellent. Some of the emulsified cosmetics with poor stability over time were found.
さらに、表１Ａ及び表１Ｂが示すとおり、実施例１〜実施例１５の水中油型乳化化粧料は、いずれのものも使用感に優れていたが、比較例１〜比較例７の水中油型乳化化粧料はいずれのものも使用感、特に皮膚へのなじみが悪いものであった。 Further, as shown in Table 1A and Table 1B, all of the oil-in-water emulsion cosmetics of Examples 1 to 15 were excellent in feeling of use, but oil-in-water emulsions of Comparative Examples 1 to 7 were used. All of the emulsified cosmetics had a bad feeling in use, especially the familiarity with the skin.
また、なじみの良悪をさらに評価するために、実施例２の水中油型乳化化粧料及び比較例１の水中油型乳化化粧料を摩擦試験に供した。試験結果として、往復回数（Ｎ）と動摩擦係数（μｋ）との関係をプロットしたグラフを図１に示す。図１に示すとおり、実施例２の水中油型乳化化粧料（図中の「○」）は、比較例１の水中油型乳化化粧料（図中の「△」）に比べて、往復回数とともに摩擦係数が大きく上昇した。このように、実施例２の水中油型乳化化粧料は、低摩擦感から高摩擦感へ大きく変化する挙動から、いつまでも肌表面においてヌルヌルした感覚を与えない、「なじみの良さ」を感じるものであることがわかった。 Further, in order to further evaluate the compatibility, the oil-in-water emulsion cosmetic of Example 2 and the oil-in-water emulsion cosmetic of Comparative Example 1 were subjected to a friction test. As a test result, a graph plotting the relationship between the number of reciprocations (N) and the coefficient of dynamic friction (μk) is shown in FIG. As shown in FIG. 1, the oil-in-water emulsified cosmetic of Example 2 (“◯” in the figure) was compared with the oil-in-water emulsified cosmetic of Comparative Example 1 (“Δ” in the figure) in the number of reciprocations. At the same time, the coefficient of friction increased significantly. As described above, the oil-in-water emulsified cosmetic of Example 2 does not give a slimy feeling on the skin surface forever because of the behavior that greatly changes from a low friction feeling to a high friction feeling, and feels “good familiarity”. I knew it was.
（３−２）閉塞性試験、保水性試験及び保湿力試験
実施例２〜実施例４の水中油型乳化化粧料及び比較例１〜比較例３の水中油型乳化化粧料について、閉塞性試験を実施した結果を表２に示す。なお、被験試料を塗布せずに同様の操作により試験した結果をコントロールとした。
(3-2) Occlusion Test, Water Retention Test, and Moisture Retention Test For the oil-in-water emulsion cosmetics of Examples 2 to 4 and the oil-in-water emulsion cosmetics of Comparative Examples 1 to 3, the occlusivity test The results of carrying out are shown in Table 2. In addition, the result of testing by the same operation without applying the test sample was used as a control.
表２が示すとおり、実施例群の水中油型乳化化粧料及び比較例群の水中油型乳化化粧料のいずれにおいても、ワセリンの含有量の増加に伴い、同程度の水分蒸発抑制率であった。この結果より、得られた水中油型乳化化粧料は、高圧乳化処理の有無にかかわらず、閉塞性が維持されたものであった。 As shown in Table 2, in both the oil-in-water emulsion cosmetics of the example group and the oil-in-water emulsion cosmetics of the comparative example group, the water evaporation suppression rate was about the same as the content of petrolatum increased. It was From this result, it was found that the obtained oil-in-water type emulsion cosmetic maintained the occlusive property regardless of the presence or absence of the high pressure emulsification treatment.
また、実施例２の水中油型乳化化粧料及び比較例１の水中油型乳化化粧料について、保水性試験（水分蒸発率）及び保湿力試験（水分変化量）を実施したところ、両者の測定結果に大きな差異は認められなかった。この結果より、得られた水中油型乳化化粧料は、高圧乳化処理の有無に依拠する、保水性及び保湿力の変化は認められなかった。 Moreover, the water retention test (moisture evaporation rate) and the moisture retention test (moisture change amount) of the oil-in-water emulsified cosmetic of Example 2 and the oil-in-water emulsified cosmetic of Comparative Example 1 were performed. No significant difference was found in the results. From these results, the obtained oil-in-water emulsified cosmetics did not show changes in water retention and moisture retention depending on the presence or absence of high-pressure emulsification treatment.
（３−３）まとめ
高級脂肪酸及び高級アルコールを含有し、さらに乳化粒子のメディアン径（Ｄ５０）が１．０μｍ未満である水中油型乳化化粧料は、含有する炭化水素系油性成分によって期待される閉塞性を発揮しながらも、経時安定性に優れ、かつ、使用感に優れたものであることがわかった。
(3-3) Summary An oil-in-water emulsion cosmetic containing a higher fatty acid and a higher alcohol and further having a median diameter (D50) of the emulsified particles of less than 1.0 μm is expected depending on the contained hydrocarbon-based oily component. It was found that while exhibiting the occlusive property, it was excellent in stability over time and was excellent in usability.
以下に本発明の一態様として、経時安定性の評価が「○」であり、かつ、使用感の総合評価が「○」である蓋然性のある水中油型乳化化粧料の処方例を挙げるが、本発明の技術的範囲はこれらの処方例に限定されない。なお、表中の数値は全て「ｗｔ％」である。 Hereinafter, as one embodiment of the present invention, the evaluation of stability over time is "○", and a prescription example of a probable oil-in-water emulsion cosmetic having a comprehensive evaluation of "○" is given, The technical scope of the present invention is not limited to these formulation examples. In addition, all the numerical values in the table are “wt %”.
（処方例１） オールインワンジェル
表３に示すＡ相とＢ相とを７０℃に加熱し、高速撹拌処理をした後、室温にて高圧乳化処理を行い、次いであらかじめ均一溶解したＣ相と混合することにより調製できる。
(Formulation Example 1) All-in-one gel Phases A and B shown in Table 3 are heated to 70° C., subjected to high-speed stirring treatment, followed by high-pressure emulsification treatment at room temperature, and then mixed with C-phase which has been uniformly dissolved in advance. It can be prepared by
（処方例２） 美容液
表４に示すＡ相とＢ相とを７０℃に加熱し、高速撹拌処理をした後、室温にて高圧乳化処理を行い、次いであらかじめ均一溶解したＣ相と混合することにより調製できる。
(Prescription example 2) Serum A phase B and a phase B shown in Table 4 are heated to 70° C., subjected to high-speed agitation treatment, and then subjected to high-pressure emulsification treatment at room temperature, and then mixed with C phase which has been previously uniformly dissolved. It can be prepared by
（処方例３） サンスクリーンジェル
表５に示すＡ相とＢ相とを７０℃に加熱し、高速撹拌処理をした後、室温にて高圧乳化処理を行い、次いであらかじめ均一溶解したＣ相と混合することにより調製できる。
(Prescription example 3) Sunscreen gel Phase A and B shown in Table 5 were heated to 70° C., subjected to high-speed stirring treatment, then subjected to high-pressure emulsification treatment at room temperature, and then mixed with C-phase which had been uniformly dissolved in advance. It can be prepared by
本発明の一態様に係る水中油型乳化化粧料は、皮膚表面からの水分蒸発を抑制する閉塞力が認められながらも、使用感が良好であり、かつ、界面活性剤の量が炭化水素系油性成分の量に対して少量であることによる皮膚刺激性の危険性が低いことから、クリーム、乳液、化粧水、ジェル、美容液などのスキンケア化粧品、またはファンデーションなどのメーキャップ化粧品として利用することができるものである。使用者は、本発明の一態様に係る水中油型乳化化粧料を使用することにより、日常的に快適に、皮膚の乾燥を低減又は防止することができるようになる。
The oil-in-water emulsified cosmetic according to one aspect of the present invention has a good feeling in use while the occlusive force for suppressing the evaporation of water from the skin surface is recognized, and the amount of the surfactant is a hydrocarbon type. Since the risk of skin irritation due to its small amount relative to the amount of oily ingredients is low, it can be used as a skin care cosmetic such as cream, emulsion, lotion, gel, beauty essence, or makeup cosmetic such as foundation. It is possible. By using the oil-in-water emulsified cosmetic according to one aspect of the present invention, the user can comfortably reduce or prevent skin dryness on a daily basis.
Claims (9)
（Ａ）ワセリン、流動パラフィン、パラフィン、流動イソパラフィン、流動オゾケライト、プリスタン、スクワラン及び水素添加スクワランからなる群から選ばれる少なくとも１種の炭化水素系油性成分
（Ｂ）高級脂肪酸
（Ｃ）高級アルコール
（Ｄ）少なくとも２個の長鎖疎水基及び少なくとも２個の親水基を分子内に有する多鎖多親水基型界面活性剤 An oil-in-water emulsion cosmetic containing the following components (A) to (D) and having a median diameter (D50) of emulsified particles of less than 1.0 μm.
(A) At least one hydrocarbon-based oily component (B) higher fatty acid (C) higher alcohol (D) selected from the group consisting of petrolatum, liquid paraffin, paraffin, liquid isoparaffin, liquid ozokerite, pristane, squalane, and hydrogenated squalane. ) Multi-chain polyhydrophilic group type surfactant having at least two long chain hydrophobic groups and at least two hydrophilic groups in the molecule
前記予備乳化液を高圧ホモジナイズ処理に供して、乳化粒子のメディアン径（Ｄ５０）が１．０μｍ未満である水中油型乳化化粧料を得る工程
を含む、水中油型乳化化粧料の製造方法。
（Ａ）ワセリン、流動パラフィン、パラフィン、流動イソパラフィン、流動オゾケライト、プリスタン、スクワラン及び水素添加スクワランからなる群から選ばれる少なくとも１種の炭化水素系油性成分
（Ｂ）高級脂肪酸
（Ｃ）高級アルコール
（Ｄ）少なくとも２個の長鎖疎水基及び少なくとも２個の親水基を分子内に有する多鎖多親水基型界面活性剤 The following components (A) to (D) are subjected to a high-speed stirring treatment to obtain a preliminary emulsion, and the preliminary emulsion is subjected to a high-pressure homogenization treatment so that the median diameter (D50) of the emulsified particles is 1.0 μm. A method for producing an oil-in-water emulsified cosmetic, which comprises a step of obtaining an oil-in-water emulsified cosmetic which is less than 1.
(A) at least one hydrocarbon-based oil component selected from the group consisting of petrolatum, liquid paraffin, paraffin, liquid isoparaffin, liquid ozokerite, pristane, squalane, and hydrogenated squalane (B) higher fatty acid (C) higher alcohol (D) ) Multi-chain polyhydrophilic group type surfactant having at least two long chain hydrophobic groups and at least two hydrophilic groups in the molecule
（Ａ）ワセリン、流動パラフィン、パラフィン、流動イソパラフィン、流動オゾケライト、プリスタン、スクワラン及び水素添加スクワランからなる群から選ばれる少なくとも１種の炭化水素系油性成分
（Ｂ）高級脂肪酸
（Ｃ）高級アルコール
（Ｄ）少なくとも２個の炭素数が５〜２０個である長鎖疎水基及び少なくとも２個の親水基を分子内に有する多鎖多親水基型界面活性剤
A method for suppressing oil floating of a preliminary emulsion, comprising the step of subjecting the following components (A) to (D) to a high-speed stirring treatment to obtain a preliminary emulsion.
(A) At least one hydrocarbon-based oily component (B) higher fatty acid (C) higher alcohol (D) selected from the group consisting of petrolatum, liquid paraffin, paraffin, liquid isoparaffin, liquid ozokerite, pristane, squalane, and hydrogenated squalane. ) Multi-chain polyhydrophilic group type surfactant having at least two long-chain hydrophobic groups having 5 to 20 carbon atoms and at least two hydrophilic groups in the molecule
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018213712A JP7240144B2 (en) | 2018-11-14 | 2018-11-14 | Oil-in-water emulsified cosmetic |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018213712A JP7240144B2 (en) | 2018-11-14 | 2018-11-14 | Oil-in-water emulsified cosmetic |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2020079218A true JP2020079218A (en) | 2020-05-28 |
| JP7240144B2 JP7240144B2 (en) | 2023-03-15 |
Family
ID=70801452
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018213712A Active JP7240144B2 (en) | 2018-11-14 | 2018-11-14 | Oil-in-water emulsified cosmetic |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP7240144B2 (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06271421A (en) * | 1993-03-15 | 1994-09-27 | Shiseido Co Ltd | Oil-in-water emulsion composition |
| JP2006056851A (en) * | 2004-08-23 | 2006-03-02 | Shu Uemura:Kk | Cosmetic |
| JP2009107932A (en) * | 2007-10-26 | 2009-05-21 | Fancl Corp | Emulsified cosmetic |
| WO2014185317A1 (en) * | 2013-05-15 | 2014-11-20 | 富士フイルム株式会社 | Oil-in-water cosmetic |
| JP2015168629A (en) * | 2014-03-05 | 2015-09-28 | 日本メナード化粧品株式会社 | Oil-in-water type emulsion cosmetic |
| JP2018172367A (en) * | 2017-03-30 | 2018-11-08 | 株式会社コーセー | Skin external preparation or cosmetic |
-
2018
- 2018-11-14 JP JP2018213712A patent/JP7240144B2/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06271421A (en) * | 1993-03-15 | 1994-09-27 | Shiseido Co Ltd | Oil-in-water emulsion composition |
| JP2006056851A (en) * | 2004-08-23 | 2006-03-02 | Shu Uemura:Kk | Cosmetic |
| JP2009107932A (en) * | 2007-10-26 | 2009-05-21 | Fancl Corp | Emulsified cosmetic |
| WO2014185317A1 (en) * | 2013-05-15 | 2014-11-20 | 富士フイルム株式会社 | Oil-in-water cosmetic |
| JP2015168629A (en) * | 2014-03-05 | 2015-09-28 | 日本メナード化粧品株式会社 | Oil-in-water type emulsion cosmetic |
| JP2018172367A (en) * | 2017-03-30 | 2018-11-08 | 株式会社コーセー | Skin external preparation or cosmetic |
Also Published As
| Publication number | Publication date |
|---|---|
| JP7240144B2 (en) | 2023-03-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP4709320B2 (en) | Method for producing O / W emulsion composition | |
| WO2009145344A1 (en) | Oil‑in‑water type topical agent for skin | |
| JP2008231010A (en) | External preparation for skin | |
| JP6057461B2 (en) | Alpha gel structure and cosmetic or skin external preparation containing the same | |
| JP4425127B2 (en) | Composition for improving melasma and composition for improving dullness | |
| JP2005060234A (en) | External preparation for skin | |
| US9526682B2 (en) | Fine O/W emulsion | |
| JP6410873B1 (en) | W / O type emulsion and premix for producing the same | |
| JP2017178904A (en) | O/w type emulsifying skin external composition, and method of use thereof | |
| JP6133618B2 (en) | Water-in-oil emulsion composition | |
| WO2013021775A1 (en) | Liquid skin-conditioning composition | |
| BR112017023693B1 (en) | COSMETIC OR DERMATOLOGICAL COMPOSITION IN THE FORM OF AN OIL-IN-WATER NANOEMULSION, COSMETIC USE OF THE COMPOSITION AND USE OF THE COMPOSITION | |
| TW202308591A (en) | Cosmetic | |
| JP7240144B2 (en) | Oil-in-water emulsified cosmetic | |
| JP5645302B2 (en) | Pharmaceutical emulsion for external use | |
| JP6865522B2 (en) | Underwater oil type UV protection cosmetics | |
| JP2003306410A (en) | Powder-containing water in oil type emulsion cosmetic | |
| BR112021010721A2 (en) | COSMETIC COMPOSITIONS COMPRISING A CYCLODEXTRIN HAVING A PARTICLE SIZE DISTRIBUTION | |
| JP6674878B2 (en) | Emulsified cosmetic | |
| JPH0930925A (en) | Skin cosmetic | |
| JP6209350B2 (en) | Acne control composition, external preparation for skin and cosmetics | |
| JP7278553B2 (en) | Lutein blue light cut ability enhancer and cosmetic composition | |
| JPH11106325A (en) | Skin lotion | |
| US20210205203A1 (en) | Cosmetic composition comprising particles containing high content of ceramide and method for preparing same | |
| JP2020015677A (en) | External composition containing cholesterol and/or phytosterol |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20211018 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220628 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20220629 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20220817 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20220927 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20221124 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20230228 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20230303 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 7240144 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |