JP2020022524A - Plasma separation device - Google Patents

Abstract

To provide a plasma separation device that reduces blood cell components contained in blood.SOLUTION: A plasma separation device 1 comprises: an inflow port 3 into which blood flows; a connection channel connected to the inflow port; a first channel 9 connected to the connection channel; and a second channel 11 connected to the connection channel. The first channel is a channel connected to an inflow port 23 of a medical device body 21, the second channel is a channel connected to an outflow port 25 of the medical device body, and blood in the first channel has a lower ratio of blood cell components than blood in the second channel.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a plasma separation device and a medical device including the plasma separation device. More specifically, the present invention relates to a plasma separation device for reducing blood cell components contained in blood and a medical device including the plasma separation device.

  In long-term use medical devices such as artificial hearts, artificial valves, stents, and blood filtration devices, it is important to suppress thrombus generated by the interaction between blood and the device in order to improve reliability. Since thrombus formation is mainly initiated by the adhesion of blood cell components to the surface, conventionally, this problem has been solved by surface treatment of medical equipment.

  On the other hand, an implant artificial kidney is a medical device that removes waste products such as urea from plasma components. For this reason, it is sufficient that only the plasma component can be introduced into the implant artificial kidney. When only the plasma component is introduced into the implant artificial kidney, no thrombus is formed because there is no blood cell component. As a method for separating plasma, there is a mechanical method using a plasma separation membrane. If this method is used, thrombus may be formed in the filter part, and is not suitable for long-term use.

  On the other hand, the following non-patent document 1 (T. Kobayashi, S. Konishi ,: “Microfluidic chip with serially connected filters for improvement of collection efficiency in blood plasma separation”, Sensors & Actuators: B. Chemical, pp. 1176-1183, ( 2012.10)), a plasma separation technology using a microchannel is proposed. This technique is for performing a one-chip blood test using a small amount of blood, and is not suitable for in vivo plasma separation.

T. Kobayashi, S. Konishi ,: “Microfluidic chip with serially connected filters for improvement of collection efficiency in blood plasma separation”, Sensors & Actuators: B. Chemical, pp.1176-1183, (2012.10)

  An object of the present invention is to provide a plasma separation device capable of reducing blood cell components from blood in a living body.

  An object of the present invention is to provide a medical device that can use the medical device main body for a long period of time by reducing blood cell components flowing into the medical device main body.

  The present invention basically prevents blood clots from forming in a medical device main body by reducing blood cell components by a relatively simple device before blood flows into the medical device main body. Is based on the finding that the life of the steel can be extended.

The plasma separation device 1 of the present invention is a device for reducing blood cell components contained in blood. This plasma separation device 1
An inlet 3 into which blood flows,
A connection flow path 5 connected to the inflow port 3,
A first flow path 9 connected to the connection flow path 5,
A second flow path 11 connected to the connection flow path 5.
The first flow path 9 is a flow path connected to the inflow port 23 of the medical device main body 21.
The second flow path 11 is a flow path connected to the outlet 25 of the medical device main body 21.
The blood in the first flow path 9 has a smaller proportion of blood cell components than the blood in the second flow path 11.

  In the plasma separation device 1, it is preferable that the blood cell component of the blood flowing into the medical device main body 21 is reduced. As a specific example, the hematocrit value of the blood flowing from the first flow path 9 to the inflow port 23 of the medical device main body 21 is the same as that of the second flow path 11 when the hematocrit value is connected to the outflow port 25 of the medical device main body 21. It is lower than the hematocrit value of blood (5% or more).

  The connection flow path 5 may have a circumferential portion 7. In this case, the first flow path 9 is connected to the inner peripheral side of the connection flow path 5. Then, the blood cell component moves to the outside of the connection flow path 5 by the circumferential portion 7, so that the blood cell component contained in the blood flowing out of the first flow path 9 decreases. Examples of the circumferential portion 7 include an arc-shaped portion, a circular portion, or a spiral portion having a diameter or a major axis of 10 mm or more and 80 mm or less.

  The inflow port 3, the connection flow path 5, the first flow path 9, and the second flow path 11 have, for example, a circular, elliptical, or rectangular cross section having a diameter or a long axis of 2 mm or more and 8 mm or less. It has a channel.

  The plasma separation device 1 may be used outside a living body, or may be an implant-type plasma separation device embedded in a living body.

The medical device of the present invention is a medical device including the plasma separation device 1 described above and the medical device main body 21.
And the medical device main body 21
An inlet 23 connected to the first flow path 9,
Outflow port 25 through which blood that has flowed in through inflow port 23 flows out through medical device main body 21, and includes an outflow port 25 that is connected to second flow path 11.

  An example of the medical device main body 21 is an implant-type artificial kidney implanted in a living body.

  The present invention can provide a plasma separation device capable of reducing blood cell components from blood in a living body, and a medical device including such a plasma separation device.

  ADVANTAGE OF THE INVENTION Since the blood cell component introduce | transduced into a medical device main body can be reduced according to this invention, the thrombus of the medical device main body can be suppressed and the continuous use period of a medical device can be extended.

FIG. 1 is a block diagram showing a plasma separation device and medical equipment of the present invention. FIG. 2 is a conceptual diagram showing an example of the plasma separation device of the present invention. In this example, the blood cell component having a high specific gravity moves on the outer peripheral side of the connection flow path, and moves to the second flow path in a large amount. In this plasma separation device, a flow path is provided on a substrate. FIG. 3 is a conceptual diagram showing an example of the plasma separation device of the present invention. In this example, the blood cell component travels straight along the branch path in accordance with the law of inertia and moves to the second flow path a lot. FIG. 4 is a conceptual diagram showing an example of the plasma separation device of the present invention. In this example, there are a plurality of first flow paths. In this example, the plasma separation device is formed by a tube. FIG. 5 is a conceptual diagram showing an example of the plasma separation device of the present invention. In this example, the connection flow path is formed in a spiral shape. FIG. 6 is a conceptual diagram showing an example of the plasma separation device of the present invention. In this example, a magnet is installed on the outer periphery of the connection flow path, and sensors are mounted on the first flow path and the second flow path. FIG. 7 is a conceptual diagram showing an example of a cross section of the connection flow channel of the present invention. FIG. 7 (a) shows a cross section of the connection flow path having a rectangular shape with a corner, and FIG. 7 (b) shows a cross section of the connection flow path having an elliptical (or circular) shape. 7 (c) shows a cross section of the connection flow path having a rectangular shape having a curved portion on the outer peripheral side, and FIG. 7 (d) shows a cross section of the connection flow path having a curved portion on the outer peripheral side. It shows a shape that exists and becomes narrower as the inner circumference approaches the inner circumference. FIG. 8 is a conceptual diagram showing an example of the principle when the plasma separation device of the present invention separates a plasma component from blood. FIG. 9 is a conceptual diagram showing an example of an implant type artificial kidney. FIG. 10 shows a configuration example of the artificial kidney 41. FIG. 11 is a design diagram in the first embodiment. FIG. 12 is a graph instead of a drawing showing the hematocrit value measured in Example 1. FIG. 13 is a photograph replacing a drawing showing the plasma separation device manufactured in Example 3.

  Hereinafter, embodiments for carrying out the present invention will be described with reference to the drawings. The present invention is not limited to the embodiments described below, but also includes those appropriately modified by those skilled in the art from the following embodiments.

  FIG. 1 is a block diagram showing a plasma separation device and medical equipment of the present invention. FIG. 2 is a conceptual diagram showing an example of the plasma separation device of the present invention. As shown in FIGS. 1 and 2, the plasma separation device 1 includes an inlet 3 into which blood flows, a connection channel 5 connected to the inlet 3, and a first channel 5 connected to the connection channel 5. And the second flow path 11 connected to the connection flow path 5.

  The medical device 27 of the present invention includes the plasma separation device 1 and the medical device main body 21. The medical device main body 21 includes an inflow port 23 connected to the first flow path 9, and an outflow port 25 through which blood flowing from the inflow port 23 flows out through the medical device main body 21. 11 and those connected to it.

  The plasma separation device 1 of the present invention is a device for reducing blood cell components contained in blood. That is, the plasma separation device 1 is a medical device for reducing blood cell components (red blood cells and white blood cells) contained in blood flowing into the medical device body.

  In the plasma separation device 1, it is preferable that the blood cell component of the blood flowing into the medical device main body 21 is reduced. As a specific example, the hematocrit value of the blood flowing from the first flow path 9 to the inflow port 23 of the medical device main body 21 is the same as that of the second flow path 11 when the hematocrit value is connected to the outflow port 25 of the medical device main body 21. It is lower than the hematocrit of blood (5% or more, 10% or more, or 15% or more). The value of the hematocrit value may be measured by a sensor if the sensor is attached to the plasma separation device. In addition, the value of the hematocrit value may be measured using standard blood or artificial blood before implantation into a living body.

  The inflow port 3 is a portion into which blood derived from a living body flows into the plasma separation device 1. Methods for connecting a blood vessel and an inlet are known. As an example of a method of connecting a blood vessel and an inflow port, an artificial blood vessel is connected to a blood vessel in a living body, and an attachment is attached to a side of the artificial blood vessel that is not connected to the blood vessel. Then, the blood vessel and the inflow port are connected by connecting the attachment and the inflow port (for example, by heat fusion). Thus, even in the living body, the blood vessel and the inflow port can be connected, and the blood circulating in the living body can flow into the plasma separation device 1.

  The connection flow path 5 is a part where the blood flowing from the inflow port 3 moves to each part described below. The first flow path 9 is a flow path connected to the inflow port 23 of the medical device main body 21. The second flow path 11 is a flow path connected to the outlet 25 of the medical device main body 21. In the plasma separation device 1, the blood in the first flow path 9 has a smaller proportion of blood cell components than the blood in the second flow path 11.

  In the example of FIG. 2, the blood cell component having a high specific gravity moves on the outer peripheral side of the connection flow path, and moves much to the second flow path. In this plasma separation device, a flow path is provided on a substrate. As shown in FIG. 2, the connection flow path 5 may have a circumferential portion 7. In this case, the first flow path 9 is connected to the inner peripheral side of the connection flow path 5. Then, the blood cell component moves to the outside of the connection flow path 5 by the circumferential portion 7, so that the blood cell component contained in the blood flowing out of the first flow path 9 decreases. Examples of the circumferential portion 7 include an arc portion, a circular portion, and a spiral shape having a diameter or a major axis of 10 mm or more and 80 mm or less (10 mm or more and 70 mm or less, 10 mm or more and 50 mm or less, 15 mm or more and 70 mm or less, or 20 mm or more and 50 mm or less). It has a portion. This size may be appropriate in accordance with the size of the target when the plasma separation device is implanted in a living body. In the example shown in FIG. 2, the depressions or holes provided in the substrate 12 form the inflow port 3, the connection flow path 5, the first flow path 9, and the second flow path 11. The substrate 12 is made of plastic (for example, acrylic or methacrylic resin) or metal (for example, copper, titanium, stainless steel, aluminum, gold, platinum, or an alloy thereof). The substrate 12 may be provided with a hole 14 for connecting the medical device main body 21 and the plasma separation device 1. The substrate 12 has a quadrangular (quadrangular prism) shape. Although not shown, it is preferable that the corners are chamfered (processed to form a smooth curve). This is the same in the following. In the example shown in FIG. 2, the circumferential portion 7 makes about one and a half turns while gradually reducing the radius. Circumferential portion 7 may go around more than this.

  FIG. 3 is a conceptual diagram showing an example of the plasma separation device of the present invention. In this example, the blood cell component travels straight along the branch path according to the law of inertia and moves to the second flow path 11 in a large amount. In this example, the substrate 12 has a hexagonal shape, and the circumferential portion 7 has an arc shape. In this example, the radius of the circumferential portion 7 is constant.

  FIG. 4 is a conceptual diagram showing an example of the plasma separation device of the present invention. In this example, a plurality of (two) first flow paths exist. As shown in FIG. 4, the first flow path and the second flow path are a plurality of flow paths connected to the inflow port 23 of the medical device main body 21 and the outflow port 25 of the medical device main body 21, respectively. (Two or more) may be present. In this example, the plasma separation device is formed by a tube. As described above, the plasma separation device is not limited to the device formed on the substrate. Medical tubes are known, and such a plasma separation device can be manufactured by processing known tubes. Of course, the plasma separation device shown in FIG. 4 may be realized using a substrate. When the plasma separation device is formed by a tube, a hard tube may be used so that the shape of the circumferential portion 7 does not change.

  Examples of tube materials include polyvinyl chloride, polyethylene, polypropylene, cyclic polyolefin, polystyrene, polycarbonate, acrylic resin, methacrylic resin, acrylonitrile-butadiene-styrene copolymer, polyethylene terephthalate, butadiene-styrene copolymer, polyamide ( For example, nylon 6, nylon 6,6, nylon 6,10, nylon 12), natural rubber, butyl rubber, isoprene rubber, butadiene rubber, styrene-butadiene rubber, silicone rubber, seed thermoplastic elastomer, titanium, stainless steel, aluminum, Copper and copper-based alloys.

  FIG. 5 is a conceptual diagram showing an example of the plasma separation device of the present invention. In this example, the connection flow path is formed in a spiral shape.

  FIG. 6 is a conceptual diagram showing an example of the plasma separation device of the present invention. In this example, a magnet 31 is provided on the outer periphery of the connection channel, and the red blood cell component is attracted to the outside of the connection channel by the magnetic force. The first flow path 9 is connected to the inner peripheral side of the connection flow path 5 (on the side opposite to the side where the magnet is provided with respect to the connection flow path). Then, the blood cell component moves in the outer side of the connection flow channel 5 in the circumferential portion 7, so that the blood cell component included in the blood flowing out of the first flow channel 9 decreases. The magnetic force of the magnet 31 may be appropriately adjusted. The magnet may be provided so as to surround the circumferential portion 7 or may be provided along the whole or a part of the connection flow path. In addition, the magnet may be provided immediately before the branch portion where the first flow path 9 and the second flow path 11 branch. The magnet may be housed in a housing surrounding the magnet whose only surface facing the circumferential portion 7 is open. By doing so, the situation where the magnetic flux leaks into the living body can be reduced.

  As shown in FIG. 6, sensors 33 and 35 may be attached to one or both of the first flow path 9 and the second flow path 11 to sense the amount of a blood cell component or the flow rate of blood.

  FIG. 7 is a conceptual diagram showing an example of a cross section of the connection flow channel of the present invention. FIG. 7 (a) shows a cross section of the connection flow path having a rectangular shape with a corner, and FIG. 7 (b) shows a cross section of the connection flow path having an elliptical (or circular) shape. 7 (c) shows a cross section of the connection flow path having a rectangular shape having a curved portion on the outer peripheral side, and FIG. 7 (d) shows a cross section of the connection flow path having a curved portion on the outer peripheral side. It shows a shape that exists and becomes narrower as the inner circumference approaches the inner circumference. When the cross-sectional shape of the connection flow path is asymmetric, the blood flow in the connection flow path becomes asymmetric, and the blood cell component and the plasma component are easily separated. The inflow port 3, the connection flow path 5, the first flow path 9, and the second flow path 11 have, for example, a diameter or a long axis of 2 mm or more and 8 mm or less (or 3 mm or more and 7 mm or less, 3 mm or more and 5 mm or less, 2 mm or more). (4 mm or less) having a circular, elliptical, or rectangular cross section.

  FIG. 8 is a conceptual diagram showing an example of the principle when the plasma separation device of the present invention separates a plasma component from blood. In the example shown in FIG. 8, a blood cell component having a high specific gravity is likely to be unevenly distributed outside (outer peripheral side) of the connection flow path. In this state, by providing the first flow path 9 inside the connection flow path (inner side), the plasma component contained in the blood flowing into the first flow path 9 can be reduced.

  The plasma separation device 1 may be used outside a living body, or may be an implant-type plasma separation device embedded in a living body.

  The medical device of the present invention is a medical device including the plasma separation device 1 described above and the medical device main body 21. Examples of the medical device main body 21 are an implantable artificial kidney (blood filtration device), an artificial blood circulator and an artificial heart, an artificial valve, and a stent that are implanted in a living body. Among these, an implant-type artificial kidney (blood filtration device) is preferable. FIG. 9 is a conceptual diagram showing an example of an implant-type artificial kidney (blood filtration device). The artificial kidney 41 is of an implant type used by being implanted in the body of a mammal such as a human, a dog or a cat having a reduced renal function. This artificial kidney has a structure in which blood is filtered and a filtrate taken out of the blood is discharged from the bladder or directly out of the body.

  The artificial kidney 41 illustrated in FIG. 9 includes a main body 42 having a hexagonal outer shape. The main body 42 has a laminated structure formed by laminating a plurality of plate members. A blood inlet 43, a blood outlet 44, and a filtrate outlet 45 are provided on one surface of the main body 42 in the stacking direction. The blood inlet 43 allows blood to flow into the main body 42, and the blood outlet 44 allows blood from the main body 42 to flow out. Then, the filtrate outlet 45 discharges the filtrate that has been filtered in the main body 42 and extracted from the blood. The blood inlet 43, the blood outlet 44, and the filtrate outlet 45 each have a connector shape to which a tube can be connected.

  FIG. 10 shows a configuration example of the artificial kidney 41. As shown in FIG. 10, the main body 42 of the artificial kidney 41 has a structure in which a blood membrane layer 51 and a filtrate channel layer 52 are alternately stacked with a filtration membrane 53 interposed therebetween. I have. FIG. 10 shows a configuration example in which one blood flow channel layer 51 and one filtrate flow channel layer 52 are prepared and laminated in order to easily explain the structure of the artificial kidney 41. However, the artificial kidney 41 may have a configuration in which a plurality of blood flow channel layers 51 and a filtrate flow channel layer 52 (and a filtration membrane 53) are alternately stacked to be stacked in tens or hundreds of layers. The number of layers can be appropriately changed according to the mammal to which the artificial kidney 41 is attached. The main body 42 of the artificial kidney 41 is sandwiched between the first end plate 54 and the second end plate 54 from both sides in the stacking direction, integrated using fastening means (for example, bolts and nuts), and compressed in the stacking direction. It is kept in the state.

  The blood channel layer 51 includes a blood channel through which blood flows, and the filtrate channel layer 52 includes a filtrate channel through which a filtrate flows. In the main body 42, the blood flow path layer 51 and the filtrate flow path layer 52 are arranged at positions where the blood flow path and the filtrate flow path face each other via the filtration membrane 53, and blood flows through the blood flow path. In the process, the blood is filtered by the filtration membrane 53, and the harmful substances and excess water in the blood flow into the filtrate channel, and are discharged from the filtrate outlet 45 as the filtrate. It is preferable that the blood channel and the filtrate channel have at least one or more folded portions in the middle of the channels.

  In the medical device of the present invention, the plasma separation device 1 and the medical device main body 21 may be integrally formed, or may be fastened through a connecting portion such as a hole. In this case, the layer forming the plasma separation device 1 and the layer forming the medical device main body 21 may be integrally manufactured using a technique such as a 3D printer. Needless to say, a layer constituting the plasma separation device 1 and a layer constituting the medical device main body 21 are separately provided, and are present in different portions, and the inlet 23 connected to the first flow path 9 is connected. The second flow path may be connected to the outlet 25 of the medical device main body 21. In the artificial kidney, the outlet 25 of the medical device body 21 means a blood outlet 44 or a path connected to the blood outlet 44.

  For example, in the case where the plasma separation device 1 and the medical device main body 21 are integral with each other, a layer constituting the plasma separation device 1 exists at an upper portion, and a layer constituting the medical device main body 21 exists at a lower portion. You may. In this case, a blood inlet 43, a blood outlet 44, and a filtrate outlet 45 as shown in FIG. 9 may be provided on the upper surface of the plasma separation device 1. In this case, the blood outlet of the layer constituting the medical device main body 21 such as the artificial kidney existing in the lower layer is connected to the layer constituting the upper plasma separation device 1 through a path. Then, the blood flowing out from the artificial kidney reaches the upper part of the plasma separator 1 through the layers constituting the plasma separator 1, thereby flowing out from the upper part of the plasma separator 1 (the blood outlet provided at the upper part). You may make it. When the medical device main body 21 is an artificial kidney, the same applies to the filtrate outlet 45. The path connected to the filtrate outlet of the artificial kidney is connected to the upper layer constituting the plasma separation device 1, whereby the filtrate flowing out of the artificial kidney flows to the upper portion of the plasma separation device 1 (the filtrate outlet provided at the upper portion). May flow out of the system. By doing so, the liquid inlet / outlet can be concentrated on one surface (the upper surface of the plasma separation device), and the medical device can be effectively embedded in the living body.

  This plasma separation device can separate blood into a component having a large number of blood cells and a portion having a small number of blood cells (plasma portion) by passing the blood through an inlet. By embedding this plasma separation device in a living body, blood cell components can be reduced from blood flowing into a medical device. In addition, by mixing the component having increased blood cells with the blood flowing out of the medical device, it is possible to prevent a situation in which the blood cell components are damaged. The medical device of the present invention may be implanted in a living body or used outside a living body, similarly to a normal medical device.

FIG. 11 is a design diagram in the first embodiment. A plasma separation device was prepared according to the design diagram shown in FIG. In FIG. 11, “inlet” means an inflow port, and “outlet” means an outflow port, which corresponds to a first flow path and a second flow path. Grooves were formed in two acrylic plates according to the design diagram shown in FIG. The two acrylic plates were combined, and the ends were pressed to integrate the two acrylic plates. Tubes were connected to the inlet and outlet.

  Ht (hematocrit) values at the inflow section, the inner outlet (first flow path), and the outer outlet (second flow path) were measured. FIG. 12 shows the result. FIG. 12 is a graph instead of a drawing showing the hematocrit value measured in Example 1. As shown in FIG. 12, the inner outlet has a smaller 10-20% Ht value than the inflow portion. That is, it can be seen that the use of this plasma separation device can reduce the blood cell component of about 10 to 20% from the blood flowing into the medical device body. This means that the rate of thrombus formation in the medical device main body can be considerably reduced, and it has been shown that the life of the medical device can be drastically extended by using the plasma separation device of the present invention.

  A plasma separator was prepared in the same manner as in Example 1 except that the circumference was set to 40 mm. Although the blood cell component could be reduced by this plasma separation device, the effect of reducing the blood cell component in Example 1 was excellent.

  A plasma separator was prepared in the same manner as in Example 1 except that the circumference was changed to 70 mm. The obtained plasma separation device is shown in FIG. FIG. 13 is a photograph replacing a drawing showing the plasma separation device manufactured in Example 3. In this example, each channel was formed in an acrylic plate. Although the blood cell component could be reduced by this plasma separation device, the effect of reducing the blood cell component in Example 1 was excellent.

  The present invention can be used in the field of medical devices.

DESCRIPTION OF SYMBOLS 1 Plasma separation apparatus 3 Inflow port 5 Connection flow path 7 Circumferential part 9 1st flow path 11 2nd flow path 21 Medical device main body 23 Inflow port 25 Outflow port 27 Medical device

Claims (8)

A plasma separation device (1) for reducing blood cell components contained in blood,
The plasma separation device (1)
An inlet (3) through which blood flows in,
A connection channel (5) connected to the inflow port (3),
A first flow path (9) connected to the connection flow path (5),
A second flow path (11) connected to the connection flow path (5),
The first flow path (9) is a flow path connected to the inflow port (23) of the medical device main body (21),
The second flow path (11) is a flow path connected to the outlet (25) of the medical device main body (21),
The blood in the first flow path (9) has a smaller percentage of blood cell components than the blood in the second flow path (11),
Plasma separation device (1). The plasma separation device (1) according to claim 1, wherein:
The hematocrit value of the blood flowing from the first flow path (9) to the inflow port (23) of the medical device main body (21) is equal to the hematocrit value at the time of connection with the outflow port (25) of the medical device main body (21). A plasma separation device (1) that reduces the hematocrit value of blood in the second flow path (11) by 5% or more. The plasma separation device (1) according to claim 1, wherein:
The connection channel (5) has a circumferential portion (7),
The first flow path (9) is connected to the inner peripheral side of the connection flow path (5), and the blood cell component moves to the outside of the connection flow path (5) by the circumferential portion (7). A blood plasma separation device (1) in which a blood cell component contained in blood flowing out of a first flow path (9) is reduced. The plasma separation device (1) according to claim 3, wherein
The plasma separation device (1), wherein the circumferential portion (7) has an arc-shaped portion, a circular portion, or a spiral portion having a diameter or a major axis of 10 mm or more and 80 mm or less. The plasma separation device (1) according to claim 1, wherein:
The inflow port (3), the connection flow path (5), the first flow path (9), and the second flow path (11) have a circular shape or an elliptical shape whose diameter or major axis is 2 mm or more and 8 mm or less. Or a plasma separation device (1) having a flow path having a rectangular cross section.   The implant-type plasma separation apparatus (1) according to claim 1, wherein the apparatus is an implant-type plasma separation apparatus that is implanted in a living body. A medical device (27) comprising the plasma separation device (1) according to claim 1 and a medical device main body (21),
The medical device body (21)
An inlet (23) connected to the first channel (9),
An outlet (25) through which blood flowing from the inlet (23) flows out through the medical device body (21), including an outlet connected to a second flow path (11);
Medical equipment.   The medical device according to claim 7, wherein the medical device main body (21) is an implantable artificial kidney implanted in a living body.

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