JP2019523274A5 - - Google Patents

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Publication number

JP2019523274A5

JP2019523274A5 JP2019504104A JP2019504104A JP2019523274A5 JP 2019523274 A5 JP2019523274 A5 JP 2019523274A5 JP 2019504104 A JP2019504104 A JP 2019504104A JP 2019504104 A JP2019504104 A JP 2019504104A JP 2019523274 A5 JP2019523274 A5 JP 2019523274A5

Authority

JP

Japan

Prior art keywords

cellulose

composition

composition according

hyaluronic acid

poloxamer

Prior art date

2017-07-26

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 239000000203 mixture Substances 0.000 claims 22
• 239000000853 adhesive Substances 0.000 claims 12
• 230000001070 adhesive effect Effects 0.000 claims 12
• 229920002678 cellulose Polymers 0.000 claims 11
• 239000001913 cellulose Substances 0.000 claims 11
• 235000010980 cellulose Nutrition 0.000 claims 11
• 239000013543 active substance Substances 0.000 claims 8
• 150000003839 salts Chemical class 0.000 claims 8
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 7
• RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 7
• 229920002674 hyaluronan Polymers 0.000 claims 7
• 229960003160 hyaluronic acid Drugs 0.000 claims 7
• 229960000502 poloxamer Drugs 0.000 claims 7
• 229920001983 poloxamer Polymers 0.000 claims 7
• 238000002347 injection Methods 0.000 claims 3
• 239000007924 injection Substances 0.000 claims 3
• IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 claims 2
• 239000004375 Dextrin Substances 0.000 claims 2
• 229920001353 Dextrin Polymers 0.000 claims 2
• 239000001856 Ethyl cellulose Substances 0.000 claims 2
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 claims 2
• 239000004372 Polyvinyl alcohol Substances 0.000 claims 2
• 239000004115 Sodium Silicate Substances 0.000 claims 2
• 229920002472 Starch Polymers 0.000 claims 2
• 230000003115 biocidal effect Effects 0.000 claims 2
• 230000036760 body temperature Effects 0.000 claims 2
• 235000019425 dextrin Nutrition 0.000 claims 2
• 229920001249 ethyl cellulose Polymers 0.000 claims 2
• 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
• 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
• 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
• UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
• 239000007788 liquid Substances 0.000 claims 2
• 229920000609 methyl cellulose Polymers 0.000 claims 2
• 239000001923 methylcellulose Substances 0.000 claims 2
• 230000009854 mucosal lesion Effects 0.000 claims 2
• 239000011118 polyvinyl acetate Substances 0.000 claims 2
• 229920002451 polyvinyl alcohol Polymers 0.000 claims 2
• 235000019422 polyvinyl alcohol Nutrition 0.000 claims 2
• 230000002265 prevention Effects 0.000 claims 2
• 239000011347 resin Substances 0.000 claims 2
• 229920005989 resin Polymers 0.000 claims 2
• 239000000661 sodium alginate Substances 0.000 claims 2
• 235000010413 sodium alginate Nutrition 0.000 claims 2
• 229940005550 sodium alginate Drugs 0.000 claims 2
• NTHWMYGWWRZVTN-UHFFFAOYSA-N sodium silicate Chemical compound [Na+].[Na+].[O-][Si]([O-])=O NTHWMYGWWRZVTN-UHFFFAOYSA-N 0.000 claims 2
• 229910052911 sodium silicate Inorganic materials 0.000 claims 2
• 239000008107 starch Substances 0.000 claims 2
• 235000019698 starch Nutrition 0.000 claims 2
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims 2
• 229920002554 vinyl polymer Polymers 0.000 claims 2
• LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims 1
• KIUKXJAPPMFGSW-YXBJCWEESA-N (2s,4s,5r,6s)-6-[(2s,3r,5s,6r)-3-acetamido-2-[(3s,4r,5r,6r)-6-[(3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical group CC(=O)N[C@H]1C(O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@@H]3[C@@H]([C@@H](O)C(O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)C(C(O)=O)O1 KIUKXJAPPMFGSW-YXBJCWEESA-N 0.000 claims 1
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
• 206010009944 Colon cancer Diseases 0.000 claims 1
• 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
• 229920000896 Ethulose Polymers 0.000 claims 1
• ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims 1
• 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims 1
• 239000004354 Hydroxyethyl cellulose Substances 0.000 claims 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
• QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 1
• SMEGJBVQLJJKKX-HOTMZDKISA-N [(2R,3S,4S,5R,6R)-5-acetyloxy-3,4,6-trihydroxyoxan-2-yl]methyl acetate Chemical compound CC(=O)OC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O)OC(=O)C)O)O SMEGJBVQLJJKKX-HOTMZDKISA-N 0.000 claims 1
• 229940081735 acetylcellulose Drugs 0.000 claims 1
• 229960002833 aflibercept Drugs 0.000 claims 1
• 108010081667 aflibercept Proteins 0.000 claims 1
• 229960000397 bevacizumab Drugs 0.000 claims 1
• 229920003090 carboxymethyl hydroxyethyl cellulose Polymers 0.000 claims 1
• 229920002301 cellulose acetate Polymers 0.000 claims 1
• 229920003086 cellulose ether Polymers 0.000 claims 1
• 229960005395 cetuximab Drugs 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 235000019325 ethyl cellulose Nutrition 0.000 claims 1
• 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims 1
• 229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 claims 1
• 229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 claims 1
• 229960000598 infliximab Drugs 0.000 claims 1
• 210000000936 intestine Anatomy 0.000 claims 1
• UWKQSNNFCGGAFS-XIFFEERXSA-N irinotecan Chemical compound C1=C2C(CC)=C3CN(C(C4=C([C@@](C(=O)OC4)(O)CC)C=4)=O)C=4C3=NC2=CC=C1OC(=O)N(CC1)CCC1N1CCCCC1 UWKQSNNFCGGAFS-XIFFEERXSA-N 0.000 claims 1
• 229960004768 irinotecan Drugs 0.000 claims 1
• 235000010981 methylcellulose Nutrition 0.000 claims 1
• HBRRZHBTWYEFRM-UHFFFAOYSA-N octadecanoic acid;sulfuric acid Chemical compound OS(O)(=O)=O.CCCCCCCCCCCCCCCCCC(O)=O HBRRZHBTWYEFRM-UHFFFAOYSA-N 0.000 claims 1
• KCCZJTJZWUNGHI-UHFFFAOYSA-N octanoic acid;sulfuric acid Chemical compound OS(O)(=O)=O.CCCCCCCC(O)=O KCCZJTJZWUNGHI-UHFFFAOYSA-N 0.000 claims 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
• 230000000306 recurrent effect Effects 0.000 claims 1
• 239000011734 sodium Substances 0.000 claims 1
• 229910052708 sodium Inorganic materials 0.000 claims 1
• 229940032147 starch Drugs 0.000 claims 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 230000000699 topical effect Effects 0.000 claims 1