JP2019517485A - Ｂ細胞増殖性障害を治療するための抗ｃｄ２０抗体、ｐ１３キナーゼ−デルタ選択的阻害剤およびｂｔｋ阻害剤の組み合わせ - Google Patents

Ｂ細胞増殖性障害を治療するための抗ｃｄ２０抗体、ｐ１３キナーゼ−デルタ選択的阻害剤およびｂｔｋ阻害剤の組み合わせ Download PDF

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JP2019517485A
JP2019517485A JP2018562232A JP2018562232A JP2019517485A JP 2019517485 A JP2019517485 A JP 2019517485A JP 2018562232 A JP2018562232 A JP 2018562232A JP 2018562232 A JP2018562232 A JP 2018562232A JP 2019517485 A JP2019517485 A JP 2019517485A
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lymphoma
antibody
cell
inhibitor
agents
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JP2019517485A5 (OSRAM
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ワイス，マイケル，エス．
ミスキン，ハリ，ピー．
スポルテリ，ピーター
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ティージー セラピューティクス，インコーポレイテッド
ティージー セラピューティクス，インコーポレイテッド
ルヒゼン ファーマスティカルズ エスエー
ルヒゼン ファーマスティカルズ エスエー
ラボラトワ フランセーズ デュ フラクションメント エ デ バイオテクノロジーズ
ラボラトワ フランセーズ デュ フラクションメント エ デ バイオテクノロジーズ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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    • C07K—PEPTIDES
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    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]

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  • Health & Medical Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
JP2018562232A 2016-05-27 2017-05-26 Ｂ細胞増殖性障害を治療するための抗ｃｄ２０抗体、ｐ１３キナーゼ−デルタ選択的阻害剤およびｂｔｋ阻害剤の組み合わせ Pending JP2019517485A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662342822P 2016-05-27 2016-05-27
US62/342,822 2016-05-27
PCT/US2017/034855 WO2017205843A1 (en) 2016-05-27 2017-05-26 Combination of anti-cd20 antibody, p13 kinase-delta selective inhibitor, and btk inhibitor to treat b-cell proliferative disorders

Publications (2)

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JP2019517485A true JP2019517485A (ja) 2019-06-24
JP2019517485A5 JP2019517485A5 (OSRAM) 2020-07-02

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JP2018562232A Pending JP2019517485A (ja) 2016-05-27 2017-05-26 Ｂ細胞増殖性障害を治療するための抗ｃｄ２０抗体、ｐ１３キナーゼ−デルタ選択的阻害剤およびｂｔｋ阻害剤の組み合わせ

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US (2) US10966977B2 (OSRAM)
EP (1) EP3463318A4 (OSRAM)
JP (1) JP2019517485A (OSRAM)
KR (1) KR20190015351A (OSRAM)
CN (1) CN109640964A (OSRAM)
AU (1) AU2017268839A1 (OSRAM)
BR (1) BR112018074238A2 (OSRAM)
CA (1) CA3024123A1 (OSRAM)
CL (1) CL2018003349A1 (OSRAM)
EA (1) EA201892284A1 (OSRAM)
IL (1) IL263239A (OSRAM)
MX (1) MX2018014577A (OSRAM)
SG (1) SG11201810333UA (OSRAM)
WO (1) WO2017205843A1 (OSRAM)

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US12133884B2 (en) 2018-05-11 2024-11-05 Beam Therapeutics Inc. Methods of substituting pathogenic amino acids using programmable base editor systems
EP3806824A1 (en) * 2018-06-15 2021-04-21 Janssen Pharmaceutica NV Formulations/compositions comprising ibrutinib
CN108743947B (zh) * 2018-07-04 2020-12-15 复旦大学附属肿瘤医院 一种治疗b细胞淋巴瘤的药物组合物
BR112022000684A2 (pt) * 2019-07-15 2022-03-03 Johnson Matthey Plc Monotosilato de umbralisibe, processo para preparar uma forma amorfa, forma amorfa de monotosilato de umbralisibe, composição farmacêutica, e, método de tratamento de doença
US20220143026A1 (en) 2020-11-12 2022-05-12 Tg Therapeutics, Inc. Triple combination to treat b-cell malignancies
AU2022254689A1 (en) * 2021-04-08 2023-11-16 Artiva Biotherapeutics, Inc. Treatment of cancer with nk cells and a her2 targeted antibody
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CA3024123A1 (en) 2017-11-30
US20210169878A1 (en) 2021-06-10
CL2018003349A1 (es) 2019-03-15
US20190175592A1 (en) 2019-06-13
BR112018074238A2 (pt) 2019-04-16
WO2017205843A1 (en) 2017-11-30
US10966977B2 (en) 2021-04-06
CN109640964A (zh) 2019-04-16
EA201892284A1 (ru) 2019-08-30
KR20190015351A (ko) 2019-02-13
IL263239A (en) 2018-12-31
MX2018014577A (es) 2019-05-20
SG11201810333UA (en) 2018-12-28
AU2017268839A1 (en) 2018-11-29
EP3463318A1 (en) 2019-04-10
EP3463318A4 (en) 2020-01-01

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