JP2019217266A - Production method for 3d custom-made implant - Google Patents

Abstract

To provide a production method for a 3D custom-made implant in which the custom-made implant of a material containing silicon can be produced, based on a CT image of a patient's body.SOLUTION: A production method for a 3D custom-made implant is disclosed. The production method for the 3D custom-made implant of the present invention is characterized by comprising: an embodiment step of embodying a 3D object (object) of a body after dividing a CT image of a patient's body using a threshold, based on a brightness value of the image of the body; a design step of designing a design implant, based on the 3D object embodied in the embodiment step; a guideline implant production step of producing the design implant by guidelines; and a production step of producing the custom-made implant with a material containing silicon in the same configuration as the guideline implant.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a method for manufacturing an implant. More specifically, the present invention relates to a method for manufacturing a 3D custom-made implant capable of manufacturing a custom-made implant made of a material containing silicon based on a CT image of a patient's body.

  In recent years, cosmetics have not been able to satisfy demands such as aging prevention, and the number of consumers who seek beauty effects by plastic surgery is increasing. Implants are used in the above-mentioned orthopedic procedures, and such orthopedic procedures include various parts of the body, such as the nose, chin, lollipop around the nose, a recessed area near the nose, an area under the eyes, and a forehead. , Muscles (gluteal) and the like.

  Among them, rhinoplasty is of many types, and the type of operation differs depending on the condition of the patient, the requirements, the type of deformation, the type and method of the previous operation, and the like.

  Rhinoplasty involves a wide range of procedures, from simply raising the nose or straightening a curved nose, to correcting congenital malformations, healing accidental defects, and reconstructing the nose after removal of cancerous tissue. Over a range of fields. Of these, rhinoplasty should be performed for corrective treatment when the nose is congenitally low or deformed, or when the nose is missing or deformed due to tumor surgery, or for cosmetic purposes There is.

  In general, rhinoplasty is performed by inserting a material, which is divided into a graft and an implant.

  The types of implants include bone and cartilage. The bone is divided into cartilage bone formed by cartilage ossification and membranous bone formed by direct ossification of mesenchymal tissue.

  In general, membranous bones such as skulls have good survival rates and low resorption rates, and are often used for autologous bone transplantation. In addition, cartilage bones such as iliac bones and ribs may be used. Cartilage has a lower absorption rate than bone tissue, can survive without blood supply, and can be easily shaped. Nasal septum cartilage, auricular cartilage and costal cartilage are mainly used for rhinoplasty.

  Among the transplants, in the case of a bone graft, a large amount of bone can be obtained because bone fusion is firmly performed, does not displace well, does not cause a foreign body reaction.

  However, fractures may occur, it may be difficult to harvest the implant, the wound may remain at the donor site, it is difficult to handle, absorbs a lot, and is inflexible. Of the autologous cartilage, the nasal septum cartilage is convenient and good, but it is not large in volume and it is difficult to form a firm nasal back line.

  Insert refers to an inert artificial material that does not undergo chemical changes, even when placed in living tissue for an extended period of time, and includes silicone prostheses, Gore-Tex® prostheses, Mersilene (registered trademark) (Trademark) mesh, allodam (registered trademark), proplast, and the like.

  On the other hand, existing augmentation rhinoplasty materials used in rhinoplasty have been produced in standard lengths and heights without regard to the size of the individual patient's nose. Therefore, physicians have spent a lot of time designing and engraving the material according to the specific needs of each patient.

  Tissue engineering techniques based on traditional stem cell research have shown the potential to replace damaged tissues and organs while maintaining their inherent functions, but the application of tissue engineering techniques in orthopedics is relatively rare. . That is, in most cases, the use of a suitable material to achieve the main purpose in plastic surgery is essential.

  Recently, three-dimensional (3D) printing has been applied to various clinical problems, and 3D printing can be used to produce solid scaffolds in three-dimensional shapes.

  However, none of the previous studies applied 3D printing to rhinoplasty or nasal surgery.

  The reason that the top nose among the orthopedic parts is not produced with a custom-made implant is that bone is used for up to one-third of the upper part of the nose, while two-thirds of the lower part are non-bone cartilage and cartilage. Since it is a muscle layer that covers the CT, it was not embodied on computed tomography (CT). Therefore, there have been difficulties in producing implants suitable for human tissues such as cartilage and bone.

  In addition, custom-made implants such as chin, paranasal, forehead, temple wrinkle (paranasal), lower jaw (mandible), temple, temple and cheekbone (Malar) that fit the facial bone are also limited by the material. Production was difficult.

  The above-mentioned technical configuration is a background art for deepening the understanding of the present invention, and does not mean a prior art well known in the technical field to which the present invention belongs.

Korean Registered Patent Publication No. 10-1747326 (Shim Minbo) 2017.6.008.

  The present invention has been made in view of the above points, and provides a method for manufacturing a 3D custom-made implant that can manufacture a custom-made implant made of a material containing silicon based on a CT image of a patient's body. The purpose is to:

  According to an aspect of the present invention, a CT image of a patient's body is divided using a threshold based on the brightness value of the image of the body using a threshold, and then a 3D object of the body is embodied. A design stage of designing a design implant based on the 3D object embodied in the implementation stage; a guideline implant fabrication stage of fabricating the design implant according to guidelines; and a custom made of a material including silicon in the same form as the guideline implant. A method of manufacturing a 3D custom-made implant, including a manufacturing step of manufacturing a maid implant.

  The designing may further include obtaining confirmation of a customer including a hospital.

  The guideline implant manufacturing step may be performed using a 3D printer.

  Guideline The custom-made implant manufactured in the implant manufacturing stage may be provided as a guideline indicating the shape and shape.

  In the manufacturing step, the custom-made implant can be manufactured by a manufacturing method including milling and casting.

  The manufacturing step includes, after kneading the gypsum, immersing the guideline implant at a certain depth on one side of the kneaded first kneaded gypsum; and kneading the second kneaded gypsum similarly to the first kneaded gypsum, Removing the guideline implant after curing the first kneaded gypsum and the second kneaded gypsum; and applying a liquid form between the gaps formed by removing the guideline implant. After injecting a material including silicon, curing the material may be included.

  In the implementation step, a CT image of an existing patient's body may be used.

  The method for manufacturing a 3D custom-made implant of the present invention can manufacture a custom-made implant made of a material containing silicon based on a CT image of a patient's body.

FIG. 3 is a flowchart schematically illustrating a method of manufacturing a 3D custom-made implant according to an embodiment of the present invention. FIG. 2 is a diagram schematically illustrating that a nasal bone, a cartilage and a muscle are embodied in a CT image according to the embodied stage illustrated in FIG. 1. FIG. 2 is a view schematically illustrating a design nasal implant designed in a design stage illustrated in FIG. 1 provided on an upper part of a bone; 2 is a diagram schematically illustrating a nasal implant as an example of a custom-made implant manufactured by the manufacturing method of FIG. 1. FIG. 3 is a view schematically showing that the nasal implant shown in FIG. 2 is attached to a model bone. 1 is a diagram schematically illustrating that the present embodiment can be applied to a forehead, a chin, and the like in addition to a nose.

  For a fuller understanding of the invention, its operational advantages, and the objects achieved by the practice of the invention, reference should be made to the accompanying drawings, which illustrate preferred embodiments of the invention, and to the accompanying drawings. I have to.

  Hereinafter, the present invention will be described in detail by describing preferred embodiments of the present invention with reference to the accompanying drawings. The same reference numerals provided in each drawing indicate the same members.

  FIG. 1 is a flowchart schematically illustrating a method of manufacturing a 3D custom-made implant according to an embodiment of the present invention. FIG. 2 is a flowchart illustrating a method of manufacturing a 3D custom-made implant according to an embodiment of the present invention. FIG. 3 is a view schematically illustrating that a human body tissue such as a muscle is embodied, and FIG. 3 is a view schematically illustrating that a designed nasal implant designed in a design stage illustrated in FIG. 1 is provided on an upper part of a bone. 4 is a diagram schematically illustrating a nasal implant as an example of a custom-made implant manufactured by the manufacturing method of FIG. 1, and FIG. 5 is a nasal implant illustrated in FIG. 2. 3 is a view schematically illustrating that a is attached to a model bone.

  As shown in these drawings, the method for manufacturing a 3D custom-made implant according to the present embodiment converts a CT (computerized tomography) image of a patient's nose to the light and dark values of human tissues such as the nose bone 10, cartilage 30 and muscle 20. An example of a design implant based on the CT image embodied in the embodied stage after embodying the nasal bone 10, cartilage 30, muscle 20, etc. in the CT image after segmentation using thresholding (thresholding). A design step S20 for designing the designed nasal implant 200, a guideline nasal implant manufacturing step S30 which is an example of a guideline implant for manufacturing the designed nasal implant 200 according to the guideline, and a material including silicon in the same form as the guideline nasal implant. Custom made imp And a production step (S40) fabricating a nasal implant 100 is an example of a cement.

  In the implementation step S10, a CT image of the nose is first obtained through a CT device, and the CT image of the nose can be obtained through a conventional CT imaging device. In this embodiment, the CT image of the nose can be obtained through a customer, for example, a hospital.

  In the implementation step S10 of the present embodiment, the nose bone 10, cartilage 30 and muscle 20 can be embodied in the CT image shown in FIG.

  Specifically, the bone is used up to 1/3 of the upper part of the nose before, but the lower 2/3 site is the non-bone cartilage 30 and the muscle 20 layer covering the cartilage 30, so that CT is used. Therefore, the designed nasal implant 200 shown in FIG. 2 could not be realized.

  However, in this embodiment, when the CT image of the patient is thresholded using a slice 2D image, each light and dark value can be classified. , Bones, muscles, etc. can be expressed. In other words, the principle of classifying this means a work of using the partial 2D image of the CT image to classify the same value according to the degree of brightness of the pixel (Pixel).

  In the present embodiment, a light and dark value required by an operator is selected from the values classified by using the binarization work, and this is converted into an STL (StereoLithography) file for 3D imaging.

  After the conversion in this embodiment, a shape obtained by integrating the respective STL files required for production is defined as a 3D object.

  Next, a patient implant is designed on the 3D object, and the designed STL file is output. For reference, the STL file refers to a file format provided for saving 3D modeled data in a standard format file.

  The design step S20 is a step of designing a design nasal implant 200, which is an example of a design implant, based on the CT image embodied in the implementation step S10.

  In the present embodiment, the designed nasal implant 200 manufactured in the design step S20 can be manufactured according to the requirements written on the order form of the customer.

  In addition, according to the present embodiment, the manufactured designed nasal implant 200 can be confirmed through a hospital as a customer. If there is a correction request from the hospital during this confirmation process, the designed nasal implant 200 can be manufactured through the above-described implementation step S10.

  Further, in the present embodiment, the designed nasal implant 200 can be manufactured in two or three types and provided to a customer hospital.

  The guideline implant manufacturing step S30 is a step of manufacturing the designed nasal implant 200 using the guideline implant.

  The guideline nasal implant, which is an example of the guideline implant in this embodiment, can be manufactured using a 3D printer or through a mold. For example, in this embodiment, the guideline implant is manufactured through a method of directly designing an implant using an epoxy material after outputting a model designed using a 3D printer or outputting a skull using a 3D printer. can do.

  The manufacturing step S40 is a step of manufacturing a custom-made implant including the nasal implant 100 with a material including silicon in the same form as the guideline nasal implant confirmed by the customer.

  In the manufacturing step S of the present embodiment, the nasal implant 100 may be provided by a manufacturing method including milling, casting, and the like.

Hereinafter, manufacturing the nasal implant 100 by the casting manufacturing method will be briefly described.
First, after the gypsum is kneaded, a step of dipping the guideline nasal implant at a certain depth on one side of the kneaded first kneaded gypsum is performed. At this stage, the guideline nasal implant is soaked 2/3 in the first kneading gypsum. In the present embodiment, as the gypsum, a well-known yellow stone kneading can be used, and the same can be applied when manufacturing the second kneading gypsum.

  Next, after kneading the second kneaded gypsum similarly to the first kneaded gypsum, a step of covering the first kneaded gypsum is performed.

  Then, the process waits until the first kneaded gypsum and the second kneaded gypsum are completely hardened. In this embodiment, the curing time of the first kneaded gypsum and the second kneaded gypsum requires about 24 hours.

  When the curing is completed, one of the first kneaded gypsum and the second kneaded gypsum is separated, and the guideline nasal implant is removed.

  After removing the guideline nasal implant, silicon in a liquid form is injected into the gap between the first kneaded gypsum and the second kneaded gypsum, and then hardened at a certain temperature for a certain time.

  In the present embodiment, the constant temperature may be about 160 degrees Celsius, and the curing time may be between one and two hours. In this embodiment, other known materials such as titanium can be injected in addition to silicon in a liquid form.

  When the above-described curing time has elapsed, the nasal implant 100 is separated after removing the first kneaded gypsum and the second kneaded gypsum.

  The separated nasal implant 100 is prepared according to the same standard as the guideline nasal implant, surface-treated, and then washed and finished.

This embodiment includes a method of manufacturing an implant by milling.
Hereinafter, a method of manufacturing an implant by milling will be briefly described. Milling refers to a method in which a block-type silicon or other physical material is cut or trimmed according to the designed implant, and manufactured by a method other than milling, such as carving by hand by a technician. can do.

  On the other hand, the present embodiment is used to manufacture implants necessary for chin, paranasal part, forehead, temple wrinkle part (paranasal), lower jaw (mandible), temple, temple, cheekbone (Malar) and the like. Can be applied. FIG. 6 schematically shows that the present embodiment can be applied to a forehead, a chin, a temple wrinkle site, and the like in addition to the nose.

  The embodiments of the present invention divide a CT image of a patient's body using a threshold value based on the lightness and darkness value of the body, and among the divided lightness and darkness values, divide values (data) required by a maker. Bring it to a STL file, design the patient's implant on the 3D object that is the integrated shape of each STL file required for production, and output the designed STL file to sample the produced 3D shape By using a custom-made implant with physical properties including silicon, it is possible to provide a virtual design, reflect customer requirements more accurately, communicate smoothly with customers, and better meet customer requirements. Many can be reflected.

  As described above, the present embodiment converts a CT image of a patient's body into a 3D object shape based on the brightness of the body and converts the designed implant into a 3D object shape. By manufacturing with a maid implant, it is possible to provide a virtual design, reflect customer requirements more accurately, communicate more smoothly with customers, and reflect customer requirements more. .

  In addition, there is a great advantage in that the side effect of the surgery is reduced when the implant designed in the object space matches the bone and tissue of the patient, and the preference of the individual can be more accurately reflected. In this embodiment, the object space is defined as a space in which an object exists on a three-dimensional coordinate system on a three-dimensional surface. That is, the space created by the threshold based on the light and dark values is implanted.

  Thus, it will be obvious to those having ordinary skill in the art that the present invention can be modified and varied in various ways without departing from the spirit and scope of the present invention, without being limited to the embodiments described. It is. Accordingly, such modifications or variations should fall within the scope of the claims of the present invention.

Reference Signs List 10 nasal bone 20 nasal muscle 30 nasal cartilage 40 existing implant 100 nasal implant 200 designed nasal implant

Claims (7)

Embodying a 3D object of the body after segmenting the CT image of the patient's body using a threshold based on the brightness values of the body image;
A design step of designing a design implant based on the 3D object implemented in the implementation step;
A method for manufacturing a 3D custom-made implant, comprising: a guideline implant manufacturing step of manufacturing the design implant according to a guideline; and a manufacturing step of manufacturing a custom-made implant using a material including silicon in the same form as the guideline implant. The method of claim 1, wherein the designing step further includes obtaining confirmation of a customer including a hospital. The method of claim 1, wherein the guideline implant is manufactured using a 3D printer. The method of claim 1, wherein the custom-made implant manufactured in the step of manufacturing the implant is provided as a guideline indicating a shape and a shape. The method of claim 1, wherein the custom-made implant is manufactured by a manufacturing method including milling and casting. The manufacturing step includes:
After kneading the gypsum, dipping the guideline implant at a certain depth on one side of the kneaded first kneaded gypsum;
After kneading the second kneaded gypsum similarly to the first kneaded gypsum, covering the first kneaded gypsum;
Removing the guideline implant after curing the first and second kneaded gypsum; and injecting a material including liquid silicon in a gap between the gaps formed by removing the guideline implant, and then curing. The method for manufacturing a 3D custom-made implant according to claim 1, comprising: The method of claim 1, wherein a CT image of an existing patient's body is used in the implementation step.