JP2019216683A - Tablet and manufacturing method therefor - Google Patents

Abstract

To provide a tablet mainly containing an insoluble dietary fiber such as chitosan, capable of being dispersed in water quickly while maintaining hardness of a fixed value or more, and a manufacturing method therefor.SOLUTION: There is provided a tablet containing a powder component of at least one of chitin and chitosan, having percentage of the powder component in all solid components of 10 mass% or more, particle size of the powder component passing sieves with 80 mesh, and hardness of 8 to 30 kgf. A water-containing raw material obtained by mixing the powder component and water is dried and classified to obtain a dried powder having water content of 15 mass% or less, and a mold raw material containing the obtained dried powder is tabled molded.SELECTED DRAWING: None

Description

  The present invention relates to a tablet which can be rapidly dispersed in water while maintaining a certain hardness or more, and a method for producing the tablet.

  Tablets obtained by tableting a powder containing the active ingredient are required to have a certain hardness or more so that cracks, chips, and abrasion do not occur in the package during transportation or storage. . Further, tablets are also required to have dispersibility that disperses in water within an appropriate time. However, hardness and dispersibility of tablets are in a so-called trade-off relationship, and it is generally considered difficult to achieve both.

  Since many dietary fibers such as chitosan are fibrous in shape, powder fluidity is poor, and it is difficult to make tablets as they are. In addition, since chitosan has a low bulk specific gravity, the amount of chitosan to be filled is limited, and the obtained tablets tend to be easily worn out. Therefore, to mold tablets containing dietary fiber such as chitosan, usually, a lubricant such as talc, magnesium stearate, sucrose fatty acid ester, or crystalline lactose, crystalline cellulose and other fluidity Mix with good excipients and tablet. However, if it is mixed with other components such as a lubricant and molded, the content of dietary fiber is reduced. Therefore, development of a tablet manufacturing method capable of increasing the amount of dietary fiber in the obtained tablet while increasing the fluidity has been desired.

  Conventionally, it has been studied to manufacture tablets having both a certain degree of hardness and dispersibility by adjusting the mixing balance between the active ingredient and auxiliary components such as disintegrants and excipients. For example, a tablet in which a calcium material is blended as a molding aid to increase hardness has been proposed (Patent Document 1). In addition, a chitosan-containing tablet having improved hardness and disintegrability, which is obtained by blending a calcium powder material and crystalline cellulose and compressing the same, has been proposed (Patent Document 2). Further, a chitosan-containing tablet excellent in disintegration, in which calcium carbonate, cellulose and saponin are blended at a predetermined ratio, has been proposed (Patent Document 3). Further, an orally disintegrating tablet containing 30 to 90% by mass of N-acetylglucosamine (Patent Document 4) and a tablet containing chitosan, a calcium material, and an organic acid (Patent Document 5) have been proposed.

Japanese Patent No. 4132870 JP 2004-262860 A Japanese Patent No. 4824213 Japanese Patent No. 4403182 Japanese Patent No. 3737781

  However, although the tablets proposed in Patent Documents 1 and 2 each have a certain degree of hardness, the disintegration is still insufficient, and there is room for further improvement. In addition, in order to produce these tablets, it is necessary to mix a specific component other than the active ingredient as a molding aid, so that there is also a problem that the content of the active ingredient tends to relatively decrease. Further, Patent Document 3 does not discuss the hardness of the obtained tablet at all. Patent Document 4 discusses the disintegration time of tablets during chewing, but does not discuss disintegration in water. Furthermore, since the tablet proposed in Patent Document 5 contains an organic acid and a calcium material as components other than chitosan, the content of chitosan is small.

  The present invention has been made in view of such problems of the prior art, and an object thereof is to provide an insoluble food such as chitosan that can be rapidly dispersed in water while maintaining a certain degree of hardness. An object of the present invention is to provide a tablet containing fibers as a main component and a method for producing the tablet.

That is, according to the present invention, the following tablets are provided.
[1] A powder component containing at least one of chitin and chitosan is contained, the ratio of the powder component to the total solid content is 10% by mass or more, and the particle size of the powder component passes through a sieve of 80 mesh. Tablets having a particle size and a hardness of 8 to 30 kgf.
[2] The tablet according to [1], wherein the powder component is a chitosan powder having a degree of deacetylation of 70% or more.
[3] The tablet according to the above [1] or [2], wherein the powder component further contains a cellulose powder.
[4] The tablet according to any of [1] to [3], further comprising at least one of an excipient and a lubricant.
[5] The tablet according to any one of [1] to [4], which is an oral tablet.
[6] The tablet according to any one of the above [1] to [5], wherein a time from being poured into water at 37 ° C. in a stirring state until the original form cannot be visually observed is 120 seconds or less.

Further, according to the present invention, there is provided a method for producing a tablet described below.
[7] The method for producing a tablet according to any one of [1] to [6], wherein a powder component of at least one of chitin and chitosan having a particle size passing an 80-mesh sieve is mixed with water. Then, a step of obtaining a water-containing raw material having a water addition rate represented by the following formula (1) of 200 to 400% by mass, and drying and classifying the obtained water-containing raw material so that the water content is 15% by mass or less. A step of obtaining a certain dry powder, and a step of molding a molding material containing the obtained dry powder to obtain a tablet,
A method for producing a tablet having:
Water addition rate (% by mass) = (W / P) × 100 (1)
P: amount of powder component (g)
W: amount of water to be added (g)
[8] The method for producing a tablet according to [7], wherein after mixing the powder component and the water, the mixture is stirred under a heating condition to obtain the water-containing raw material.

  ADVANTAGE OF THE INVENTION According to this invention, the tablet containing insoluble dietary fiber, such as chitosan, which can be rapidly disperse | distributed in water, maintaining the hardness more than fixed, and its manufacturing method can be provided.

<Tablets>
Hereinafter, embodiments of the present invention will be described, but the present invention is not limited to the following embodiments. The tablet of the present invention contains at least one powder component of chitin and chitosan, and the ratio of the powder component to the total solid content is 10% by mass or more. Hereinafter, the details will be described.

(Powder component)
The powder component used in the tablet of the present invention is at least one of chitin and chitosan. Chitin is a basic polysaccharide (β- (1 → 4) -2-acetamido-2-deoxy-β-D-) having 2-acetamido-2-deoxy-D-glucose (N-acetylglucosamine) as a structural unit. Glucose). Chitosan is a deacetylated product of chitin, and is a basic polysaccharide (β- (1 → 4) -2-amino-2- having 2-amino-2-deoxy-D-glucose (glucosamine) as a structural unit. Deoxy-β-D-glucose). The powder component used in the tablet of the present invention preferably further contains cellulose powder. Chitin, chitosan, and cellulose are all industrially produced, and various grades are available. In the present invention, the use of at least one of chitin and chitosan imparts various physiological activities to the tablet, such as a fat absorption inhibitory effect, a cholesterol lowering effect, a blood pressure lowering effect, a blood uric acid level lowering effect, and a heavy metal adsorption ability. It is preferable because it can be performed.

  Chitin and chitosan are active ingredients that can exert functions such as dietary fiber, LDL cholesterol level reduction, and uric acid level reduction, and are so-called insoluble dietary fiber. The weight average molecular weight of chitin and chitosan is not particularly limited. The weight average molecular weight of chitin and chitosan is, for example, preferably from 7,000 to 3,000,000, and more preferably from 10,000 to 2,000,000. However, it is preferable that the molecular weights of chitin and chitosan are large in order to more effectively exert functions such as reduction of dietary fiber, LDL cholesterol level, and uric acid level. In particular, in the case of exhibiting a function by adsorbing waste products, bile acids, uric acid and the like in the digestive tract, it is preferable to use chitin and chitosan having a molecular weight that is insoluble in water.

  More preferably, chitosan is used as the powder component. The degree of deacetylation of chitosan is preferably 70% or more, and more preferably 75 to 99%. When chitosan having a degree of deacetylation of 70% or more is used, functions such as reduction of dietary fiber, LDL cholesterol level, and uric acid level can be more effectively exhibited.

  The degree of deacetylation of chitosan can be calculated from colloid titration and the titer. Specifically, by using a toluidine blue solution as an indicator and performing colloid titration with an aqueous solution of polyvinyl potassium sulfate, the amount of free amino groups in the chitosan molecule is determined, and the degree of deacetylation of chitosan is determined. One example of a method for measuring the degree of deacetylation is shown below.

(1) Titration test Chitosan was added to a 0.5% by mass aqueous acetic acid solution so that the pure concentration of chitosan was 0.5% by mass, and the chitosan was stirred and dissolved to obtain 100 g of 0.5% by mass of chitosan / 0.1% by mass. A 5% by mass aqueous acetic acid solution is prepared. Next, 10 g of this solution and 90 g of ion-exchanged water are stirred and mixed to prepare a 0.05% by mass chitosan solution. Further, 50 mL of ion-exchanged water and about 0.2 mL of toluidine blue solution are added to 10 g of the 0.05% by mass chitosan solution to prepare a sample solution, and titrated with a polyvinyl potassium sulfate solution (N / 400 PVSK). The titration rate is 2 to 5 ml / min, and the point at which the sample solution is changed from blue to magenta and held for 30 seconds or more is defined as the titration amount at the end point. In addition, chitosan pure content means the mass of chitosan in a raw material chitosan sample. Specifically, it is the solid content mass obtained by drying the raw material chitosan sample at 105 ° C. for 2 hours.

(2) Blank test A similar titration test is performed using ion-exchanged water instead of the 0.5% by mass chitosan / 0.5% by mass acetic acid aqueous solution used in the above titration test.

(3) Calculation of degree of acetylation X = 1/400 × 161 × f × (V−B) / 1000
= 0.4025 × f × (V−B) / 1000
Y = 0.5 / 100-X
X: Free amino group mass in chitosan (corresponding to glucosamine residue mass)
Y: Mass of bound amino group in chitosan (corresponding to mass of N-acetylglucosamine residue)
f: titer of N / 400 PVSK V: titer of sample solution (mL)
B: Blank test titer (mL)
Deacetylation degree (%)
= (Free amino group) / {(free amino group) + (bonded amino group)} × 100
= (X / 161) / (X / 161 + Y / 203) × 100
“161” is the molecular weight of a glucosamine residue, and “203” is the molecular weight of an N-acetylglucosamine residue.

  The ratio of the powder component to the total solid content contained in the tablet of the present invention is 10% by mass or more, preferably 30% by mass or more, and more preferably 60% by mass or more. When the ratio of the powder component to the total solid content is less than 10% by mass, the amount of the active ingredient such as chitosan in the tablet is small. The upper limit of the ratio of the powder component such as chitosan to the total solid content in the tablet is not particularly limited, and may be 100% by mass (that is, all solid components are powder components such as chitosan).

  The particle size of the powder component is a particle size that passes through an 80 mesh sieve (80 mesh pass), and preferably a particle size that passes through a 100 mesh sieve (100 mesh pass). When a powder component having a particle size (80 mesh on) that does not pass through an 80 mesh sieve is used, it becomes difficult to form a tablet, and the hardness of the obtained tablet decreases. The "mesh" of the sieve means the number of sieve meshes per square inch, and is based on a standard sieve specified in JIS Z 8801: 2006. The particle size of the powder component can be appropriately adjusted by sieving using a vibrating sieve equipped with a specific mesh.

(Other components)
The tablet of the present invention may contain components (other components) other than the above-mentioned powder component. Other components include common tablets such as excipients, lubricants, binders, disintegrants, colorants, flavors, flavors, odorants, emulsifiers, dispersants, and preservatives. Components used for this purpose.

  Excipients include, for example, crystalline cellulose, pullulan, glucose, guar gum, xanthan gum, sorbitol, mannitol, starch, dextrin, lactose, reduced maltose, erythritol, xylitol, sodium alginate, methylcellulose, ethylcellulose, gum arabic, hydroxypropylmethylcellulose phthalate And the like. In addition, a chitin crushed product or a chitosan crushed product before mixing with water can also be used as an excipient. When a chitosan crushed product or the like is tableted, the hardness becomes extremely high due to entanglement of fibers. For this reason, by utilizing such properties, pulverized chitosan can be used as an excipient. Specifically, by mixing a chitosan-treated product or the like dried after mixing with water and a pulverized chitosan not mixed with water, it is possible to control the balance between the hardness of the obtained tablet and the dispersibility in water. it can.

  Examples of the lubricant include eggshell powder, sucrose fatty acid ester, stearic acid, magnesium stearate, aluminum stearate, calcium stearate, talc, polyvinylpyrrolidone, and vegetable hardened oil.

  Furthermore, in addition to the above components, if necessary, water-soluble vitamins (such as vitamins B1, B2, B6, B12, and C), fat-soluble vitamins (such as vitamins A, D, and E), collagen, ginkgo biloba extract, and oligosaccharides , Acerola extract, aloe extract, royal jelly, acetaminophen, acetylsalicylic acid, ibuprofen, tramadol, benzbromarone, probenecid, sulfinpyrazone, bucolome, losartan, valsartan, telmisartan, olmesartan, irbesartan, azilsartan, mefenamic acid, candesartan, etc. Can also be blended.

  Alternatively, the tablet may be coated with a coating agent such as shellac after tablet molding to obtain a coated tablet. The amount of the coating agent is not particularly limited, but is preferably 0.1 to 2.0% by mass based on the tablet. Examples of the coating method include a method in which a coating agent is sprayed on tablets and dried, and a method using a sugar coating machine or the like.

<Tablet manufacturing method>
Next, a method for producing the above-mentioned tablet will be described. According to the tablet manufacturing method of the present invention, water is mixed with at least one powder component of chitin and chitosan, which has a particle size passing an 80-mesh sieve, and water is added. A step of obtaining a water-containing raw material having a water content of 15% by mass or less (step (1)); and a step of drying and classifying the obtained water-containing raw material to obtain a dry powder having a water content of 15% by mass or less (step (2)). ) And a step of molding a molding material containing the obtained dry powder to obtain a tablet (step (3)). Hereinafter, the details will be described.
Water addition rate (% by mass) = (W / P) × 100 (1)
P: amount of powder component (g)
W: amount of water to be added (g)

(Step (1))
In the step (1), a powder component having a particle size of 80 mesh pass and water are mixed to obtain a water-containing raw material having a water addition rate of 200 to 400% by mass. By mixing the powder component and water, the particle surface of the powder component (chitosan particles, chitin particles) can be treated. Thereby, the dispersibility of the finally obtained tablet can be improved. If a powder component of 80 mesh-on is used, molding becomes difficult. Further, without performing the step (1) or the step (2) described later, tableting is performed using the powder component obtained by pulverizing a crude body of chitin or chitosan by a cutter mill, a jet mill, or the like, as it is, The resulting tablets are less likely to disperse in water and the dispersing time is longer.

  The water content of the water-containing raw material obtained by mixing the powder component and water is 200 to 400% by mass, and preferably 300 to 400% by mass. If the water content of the water-containing raw material is less than 200% by mass, it becomes difficult to balance the hardness of the tablet with the water dispersibility. In particular, when the water content of the water-containing raw material is 100% by mass or more and less than 200% by mass, the hardness of the obtained tablet does not increase. On the other hand, when the water addition ratio of the water-containing raw material is more than 400% by mass, the mixture containing the powder component and water tends to be united, so that the workability is reduced.

  A mixer can be used to mix the powder component with water. Although the type of the mixer is not particularly limited, for example, a kneader, a cylindrical mixer, a V-type mixer, a screw-type mixer, and the like can be used.

  After mixing the powder component and water, it is preferable to obtain a water-containing raw material by stirring under heating conditions. The heating temperature is not particularly limited, but is preferably 80 ° C. or lower. When a mixture containing a powder component and water is stirred under heating conditions, compared with stirring under non-heating conditions, a certain hardness is maintained at the time of tablet molding, and the tablet characteristics of rapidly dispersing in water are reduced in a short time. Can be provided.

(Step (2))
In step (2), the water-containing raw material obtained in step (1) is dried and classified to obtain a dry powder. The water content of the dry powder is 15% by mass or less, preferably 12% by mass or less, more preferably 10% by mass or less. When the water content of the dry powder obtained by drying the water-containing raw material is more than 15% by mass, coloring and a low-molecular-weight reaction due to a Maillard reaction or the like easily occur during long-term storage.

  The water-containing raw material may be dried under heating conditions, or may be dried under reduced pressure conditions. Moreover, you may dry while mixing, and may take out from a mixer and dry in a stationary state. Drying the water-containing raw material under heating conditions is preferable because the drying time can be reduced as compared with the case of drying under non-heating conditions.

(Step (3))
In the step (3), a molding raw material containing the dry powder obtained in the step (2) is molded. Thereby, the tablet of the present invention can be obtained. The dry powder alone may be used as a molding material, or the molding material may be prepared by blending the dry powder and other components. Other ingredients include general ingredients such as excipients, lubricants, binders, disintegrants, colorants, flavors, flavors, odorants, emulsifiers, dispersants, adjuvants, preservatives, and buffers. The various components described above for constituting a typical tablet can be used. In addition, tablets can be produced by tableting raw materials for molding by a general tablet molding method using a tablet molding machine such as a tableting machine.

(Physical properties of tablets)
Tablets of the present invention produced by the above production method (for example, cylindrical tablets having a diameter of 8 mm and 200 mg, obtained by molding a molding material containing a dry powder under a compression pressure of 2 tf using a compressor). Has a hardness (tablet hardness) of 8 to 30 kgf, preferably 10 kgf or more. That is, since the tablet manufactured by the manufacturing method of the present invention has sufficiently high hardness, problems such as cracking, chipping, and abrasion hardly occur in the package during transportation or storage. The tablet hardness (tablet hardness) in the present specification is measured by using a tablet hardness tester (for example, trade name “Monsanto Tablet Hardness Tester Type B”, manufactured by Fuji Rika Kogyo Co., Ltd.) when compressing and breaking the tablet in the horizontal direction. Required load (unit: kgf). The average value measured five times for each prescription was defined as the tablet hardness.

The dispersion time of the tablet of the present invention produced by the above production method in water at 37 ° C. is preferably within 120 seconds, more preferably within 60 seconds, particularly preferably within 30 seconds. That is, the tablet produced by the production method of the present invention is excellent in dispersibility, which can be rapidly dispersed in water while maintaining a certain hardness or more. For this reason, the tablet of the present invention is unlikely to cause problems such as cracking, chipping, and abrasion in the package during transportation and storage, and has good dispersibility in water. It is suitable as disintegrating tablets, chewable tablets, dispersed tablets, health foods, agricultural materials, livestock feed, cosmetics, flocculants, and the like. The dispersion time of the tablet is a value (unit: second) measured according to the following procedure.
[Measurement of dispersion time]
About 80 mL of water at 37 ° C. is put into a 100 mL beaker, and tablets are charged from a height of 2 cm from the water surface while stirring at a rotation speed of 400 rpm with a 2 cm magnet stirrer. After the tablet comes into contact with water, it swells and disperses, and the time until the original form of the tablet cannot be visually confirmed is measured five times, and the average value is defined as the dispersion time (unit: second).

  Next, the present invention will be described more specifically with reference to examples and comparative examples, but the present invention is not limited to these examples. Hereinafter, “parts” and “%” are based on mass unless otherwise specified.

<Preparation of powder>
(Production Example 1)
A crude chitosan having a weight average molecular weight of 1,000,000 and a deacetylation degree of 85% was pulverized by a jet mill to obtain a chitosan powder having a 100 mesh pass and a water content of 8%.

(Production Example 2)
A crude chitosan having a weight average molecular weight of 1.5 million and a deacetylation degree of 91% was pulverized with a jet mill to obtain a chitosan powder having an 80 mesh pass and a water content of 7%.

(Production Example 3)
A chitosan crude having a weight-average molecular weight of 1.5 million and a deacetylation degree of 91% is pulverized by a jet mill, and has a 60-mesh pass and 80-mesh on (does not pass through an 80-mesh sieve), and has a water content of 12%. A chitosan powder was obtained.

(Production Example 4)
A crude chitin having a weight average molecular weight of 1.5 million and a degree of deacetylation of 5% was pulverized with a cutter mill to obtain a chitin powder having an 80 mesh pass and a water content of 9%.

(Production Example 5)
A coarse cellulose having a weight average molecular weight of 1,000,000 was pulverized by a cutter mill to obtain a cellulose powder having an 80 mesh pass. 100 parts of the obtained cellulose powder and 150 parts of water were put into a kneader to obtain a water-containing raw material having a water addition rate of 150%. After heating to 80 ° C. and stirring for 1 hour with the lid of the kneader, the lid was opened and dried while heating and stirring at 80 ° C. were continued. Thereafter, the mixture was classified with an 80-mesh sieve to obtain a cellulose powder having a water content of 7%.

(Production Example 6)
100 parts of the chitosan powder obtained in Production Example 1 and 300 parts of water were put into a kneader to obtain a water-containing raw material having a water addition rate of 300%. After heating to 80 ° C. and stirring for 1 hour with the lid of the kneader covered, the mixture was taken out into an enamel dish and allowed to stand in an incubator. After drying by heating to 80 ° C., the mixture was classified with an 80-mesh sieve to obtain a chitosan powder having a water content of 9%.

(Production Example 7)
100 parts of the chitosan powder obtained in Production Example 2 and 350 parts of water were put into a kneader to obtain a water-containing raw material having a water addition rate of 350%. After heating to 80 ° C. and stirring for 1 hour with the lid of the kneader, the lid was opened and dried while heating and stirring at 80 ° C. were continued. Thereafter, the mixture was classified with a 100-mesh sieve to obtain a chitosan powder having a water content of 7%.

(Production Example 8)
100 parts of the chitosan powder obtained in Production Example 2 and 250 parts of water were put in a plastic bag to obtain a water-containing raw material having a water addition rate of 250%. After closing the mouth of the plastic bag and shaking it up, down, left, and right for 15 minutes to mix the contents, the mixture was taken out into an enamel dish and allowed to stand in a vacuum dryer. After drying under reduced pressure without heating, the mixture was classified with a 100-mesh sieve to obtain a chitosan powder having a water content of 8%.

(Production Example 9)
100 parts of the chitin powder obtained in Production Example 4 and 150 parts of water were put in a plastic bag to obtain a water-containing raw material having a water addition rate of 150%. After closing the mouth of the plastic bag and shaking it up, down, left, and right for 15 minutes to mix the contents, the mixture was taken out into an enamel dish and allowed to stand in the incubator. After drying by heating to 80 ° C., the resultant was classified with an 80-mesh sieve to obtain a chitosan powder having a water content of 10%.

(Production Example 10)
100 parts of the chitosan powder obtained in Production Example 2 and 500 parts of water were put into a kneader to obtain a water-containing raw material having a water addition rate of 500%. When the mixture was stirred with the lid of the kneader, the chitosan paste gathered on the rotating shaft of the kneader and became a unit. As a result, the handling property was remarkably reduced, and it was difficult to collect.

(Production Example 11)
100 parts of the chitosan powder obtained in Production Example 3 and 350 parts of water were placed in a kneader to obtain a water-containing raw material having a water addition rate of 350%. After heating to 80 ° C. with the lid of the kneader covered and stirring for 1 hour, the lid was opened and dried while heating and stirring at 80 ° C. were continued to obtain a chitosan powder having a water content of 7%. .

<Manufacture of tablets>
(Example 1)
Using a tableting machine (trade name “HANDTAB-100”, manufactured by Ichihashi Seiki Co., Ltd., diameter of punch and die: 8 mm), a tableting pressure of 2 tf was applied to 200 mg of the chitosan powder obtained in Production Example 6, and tableting was performed. A cylindrical tablet was obtained.

(Examples 2 to 6, Reference Example 1, Comparative Examples 1 to 7)
Chitosan powder, chitin powder, cellulose powder, crystalline cellulose (trade name “Comprecel” (manufactured by Fushimi Pharmaceutical Co., Ltd.), food additive) and sucrose fatty acid ester of the types and amounts shown in Tables 1-1 to 1-2 ( A cylindrical tablet was obtained in the same manner as in Example 1, except that the trade name “DK Ester” (manufactured by Daiichi Kogyo Seiyaku Co., Ltd., food additive) was used.

<Evaluation (1)>
(Measurement of hardness)
Using a tablet hardness tester (trade name “Monsanto Tablet Hardness Tester Type B”, manufactured by Fuji Rika Kogyo Co., Ltd.), the load (unit: kgf) required for compressively breaking the tablet in the horizontal direction was measured. The average value of the loads measured five times for each prescription was defined as the tablet hardness. The results are shown in Tables 1-1 to 1-2.

(Measurement of dispersion time)
About 80 mL of water at 37 ° C. was put in a 100 mL beaker, and stirred at a rotation speed of 400 rpm using a 2 cm magnet stirrer. Next, the tablet is charged from a height of 2 cm from the water surface, and the time from when the tablet comes into contact with water until it swells and disperses and the original form of the tablet cannot be visually confirmed is measured five times. The dispersion time (unit: seconds) was used. The results are shown in Tables 1-1 to 1-2.

<Evaluation (2)>
The tablet produced in Example 1 was placed on the tongue and lightly pressed against the upper jaw. The time required for the tablet to completely disperse in the mouth was determined to be 15 seconds. In addition, the tablet produced in Example 5 was placed on the tongue and lightly pressed against the upper jaw. The time it took for the tablet to completely disperse in the mouth was 30 seconds.

  The tablet produced by the production method of the present invention is useful, for example, as an oral tablet.

Claims (8)

Containing at least one powder component of chitin and chitosan, and the proportion of the powder component in the total solid content is 10% by mass or more;
The particle size of the powder component is a particle size that passes through an 80 mesh sieve,
A tablet having a hardness of 8 to 30 kgf.   The tablet according to claim 1, wherein the powder component is a chitosan powder having a degree of deacetylation of 70% or more.   The tablet according to claim 1, wherein the powder component further comprises a cellulose powder.   The tablet according to any one of claims 1 to 3, further comprising at least one of an excipient and a lubricant.   The tablet according to any one of claims 1 to 4, which is an oral tablet.   The tablet according to any one of claims 1 to 5, wherein the time from the introduction into the stirred water at 37 ° C until the original form cannot be visually observed is within 120 seconds. A method for producing a tablet according to any one of claims 1 to 6,
A powder containing at least one of chitin and chitosan, which has a particle size passing an 80-mesh sieve, and water are mixed, and a water-containing raw material having a water addition rate of 200 to 400% by mass represented by the following formula (1) is obtained. Obtaining,
Drying and classifying the obtained water-containing raw material to obtain a dry powder having a water content of 15% by mass or less;
A step of molding a molding material containing the obtained dry powder to obtain a tablet,
A method for producing a tablet having:
Water addition rate (% by mass) = (W / P) × 100 (1)
P: amount of powder component (g)
W: amount of water to be added (g)   The tablet manufacturing method according to claim 7, wherein after mixing the powder component and the water, the mixture is stirred under a heating condition to obtain the water-containing raw material.