JP2019187685A - Skin age calculation method - Google Patents

Abstract

To estimate a dynamic characteristic value of a skin, a parameter R0, using biological information capable of being measured by a wearable apparatus and further calculate a skin age.SOLUTION: A regression equation between a heart rate at the time of activities in a daily life and a maximal extension length of a skin at the time of being sucked (hereinafter referred to as a parameter R0) measured by a skin viscoelasticity measuring device is acquired. On the basis of the regression equation, a parameter R0 of a subject's skin is estimated from a heart rate at the time of activities in the subject's daily life. Also a regression equation between the parameter R0 and actual ages is acquired in advance. By using the regression equation, the subject's skin age (an age viewed from dynamic characteristic value) is calculated from the subject's estimated parameter R0.SELECTED DRAWING: Figure 5

Description

  The present invention relates to a skin age calculation method based on a heart rate and a skin counseling method.

  Evaluation of skin age using the mechanical properties of skin as an index is prevalent in beauty-related fields such as the cosmetics industry. In particular, parameters measured by CUTOMETER (trade name) (trade name) (Courage & Khazaka), a viscoelasticity measuring device for skin, are widely used. For example, proteins in the stratum corneum that are closely related to skin aging The relationship between the degree of oxidation and the parameter R0 measured with a cute meter is investigated (Patent Document 1), or the formula for calculating the apparent age including the skin elasticity measured with the cute meter is considered. (Patent Document 2). In addition, the measurement of viscoelasticity of the skin with a cutometer is expensive in terms of probes and devices used for the measurement, and skill is required for the measurement, so in order to search for proteins that are indicators of skin viscoelasticity, The relationship between a specific protein and a parameter R2 or R7 measured with a cut meter has been investigated (Patent Document 3).

  On the other hand, in recent years, for health management, the amount of activity, blood pressure, pulse, etc. in daily life is monitored and self-managed using a wearable device (Patent Document 4). In general, it is known that the health condition affects the skin age.

JP 2006-349372 A Special table 2012-501753 gazette Japanese Patent Laid-Open No. 2006-114591 Japanese Patent Laid-Open No. 2006-131604

  The mechanical characteristic value of the skin measured with a cut meter is an index of aging change of the skin, and is also an index of the skin age that is the age in view of the mechanical characteristics of the skin (harness etc.). As described above, probes and devices used for a cute meter are expensive. In addition, when measuring the mechanical properties of the skin with a cut meter, it is necessary to adapt the subject in a constant temperature and humidity chamber capable of maintaining a constant temperature and humidity, and the measurement cannot be performed easily. Accordingly, there is a need for a new index of skin age that can be more easily measured instead of the mechanical properties of the skin measured with a cut meter.

  In this regard, the skin aging index can be easily known if the skin mechanical characteristic value can be estimated by a cut meter using the measured value of a wearable device capable of monitoring daily life for health management. In addition, since the willingness to monitor the health condition in daily life increases, it is preferable from the viewpoint of promoting health management. In this case, if the skin age that can be easily understood by the general public as an index of skin aging can be estimated, it is considered that health management is further promoted from the desire to prevent the skin age from becoming high.

  Accordingly, an object of the present invention is to make it possible to estimate a skin mechanical characteristic value called parameter R0 and to calculate skin age using biological information that can be measured by a wearable device. Here, the parameter R0 is the maximum extension length of the skin at the time of suction measured by a skin viscoelasticity measuring apparatus generally called “cute meter”.

  The inventor has surprisingly found that the correlation between the heart rate during activity obtained by monitoring daily life and the parameter R0 measured by a skin viscoelasticity measuring device called a cut meter is extremely high. Inventing a method for estimating the skin parameter R0 of the subject from the heart rate during activity of the subject based on the regression equation between the parameter R0 measured by the skin viscoelasticity measuring apparatus and the heart rate during activity did. It is also understood that the age estimated from the estimated value of the parameter R0 of the subject can be used as the skin age of the subject based on the regression equation between the parameter R0 measured by the skin viscoelasticity measuring apparatus and the actual age. Invented a method for calculating the skin age.

  That is, the present invention obtains a regression equation between the heart rate during activities of daily life and the maximum stretch length of the skin at the time of suction (that is, the parameter R0) measured by the skin viscoelasticity measuring device. Based on the above, there is provided a method for estimating the mechanical characteristics of the skin, which estimates the parameter R0 of the subject's skin from the heart rate during the activities of the subject's daily life.

  The present invention also obtains a regression equation between the parameter R0 and the actual age and uses the regression equation as a skin age calculation formula, and based on the calculation formula, the subject's parameter R0 estimated by the above-described method is used. Provided is a skin age calculation method for calculating age.

  Furthermore, the present invention provides a skin for counseling for making the skin age below the current level for cosmetic purposes, using at least one of the subject parameter R0 estimated by the above method and the skin age of the subject calculated by the above method. A counseling method is provided.

  The heart rate used in the present invention during activities in daily life can be measured using a wearable device. On the other hand, it is known that the parameter R0 measured by the skin viscoelasticity measuring device is an index of the aging change of the skin, but surprisingly, the parameter R0 measured by the skin viscoelasticity measuring device and the daily life The correlation with heart rate is extremely high. Therefore, according to the present invention, it is possible to estimate the parameter R0, which is an index of aging change of the skin, with high accuracy using the heart rate that can be easily collected during the daily life.

  Further, according to the present invention, it is possible to easily calculate the skin age, which is the age from the viewpoint of the mechanical characteristic value of the skin, using the heart rate during activities of daily life.

  Furthermore, according to the skin counseling method of the present invention, while showing at least one of the parameter R0 estimated from the heart rate during activities of daily life and the skin age calculated from the estimated value of this parameter R0, Counseling mentioned in can be performed. Accordingly, the counseling content is easily accepted by the subject.

FIG. 1A is an explanatory diagram of a skin suction method when measuring the maximum extension length during skin suction using a skin viscoelasticity measuring apparatus. FIG. 1B is an explanatory diagram of the maximum extension length (parameter R0). FIG. 2 is a relationship diagram between the average maximum heart rate shown to the subject and the parameter R0 in skin counseling. FIG. 3 is a relationship diagram between the parameter R0 and the skin age shown to the subject in skin counseling. FIG. 4 is an example of a screen shown to the subject in skin counseling. FIG. 5 is a graph showing the relationship between the average maximum heart rate and the parameter R0 in the embodiment. FIG. 6 is a graph showing the relationship between the average minimum heart rate and the parameter R0. FIG. 7 is a graph showing the relationship between the average of the highest heart rate and the stratum corneum water content.

Hereinafter, the present invention will be described in detail with reference to the drawings.
(1) Acquisition of regression equation of heart rate and parameter R0 in daily life (hereinafter also referred to as regression equation of parameter R0) According to the method for estimating the mechanical properties of skin of the present invention, an index of age-related changes in the skin of a subject The parameter R0 of the subject's skin is estimated based on the regression equation between the heart rate and the parameter R0 during activities in daily life.

  In the regression equation of this parameter R0, “heart rate during activities in daily life” is not prohibited even if it is an exercise that is not carried out on a daily basis, and is not prohibited, such as working hours, sleeping hours, meal times, meals The heart rate at the time of the activity of the life spent as usual without receiving any restrictions on the contents. Here, “active” means a state other than resting.

  As the heart rate at the time of activity, a predetermined heart rate, for example, the maximum heart rate, the median heart rate, the average heart rate, etc., among the fluctuation ranges of the heart rate at the time of activity of the day can be used. Of these, the highest heart rate is preferred. The maximum heart rate means the highest heart rate in daily life, and is different from the maximum heart rate, which is a limit value when pulsation becomes the fastest.

  The heart rate during activities in daily life is preferably an average heart rate over a period of 2 weeks or more, more preferably 4 weeks or more. For example, an average of four or more weeks of the highest daily heart rate can be used as the heart rate during activities in daily life. As a result, the correlation coefficient between the heart rate and the parameter R0 during daily activities can be made 0.7 or more.

  You may measure a pulse rate as a heart rate. The heart rate measurement method is not particularly limited, but a wearable device is preferable as the heart rate measurement device so that the heart rate in daily life can be constantly monitored. As such a wearable device, for example, an activity meter having a wristwatch type heart rate measurement function (for example, manufactured by Epson, PULSENSE, etc.) can be used.

  On the other hand, in the present invention, the parameter R0 is the maximum extension length of the skin at the time of suction measured by a skin viscoelasticity measuring apparatus generally called a cutometer. That is, as shown in FIG. 1A, when the probe is applied to the skin, the inside of the probe is sucked and kept for a predetermined time, and then the suction is released, the relationship between the length of the skin drawn into the probe (extension length) and time Is as shown in FIG. 1B. The parameter R0 is the maximum extension length of the skin drawn into the probe in this way, and is an index related to the skin mechanical characteristics such as skin firmness, flexibility, and elasticity. Examples of the skin viscoelasticity measuring apparatus include CUTERTER (trade name) (manufactured by Curage & Khazaka). As the suction conditions, it is preferable to set the predetermined conditions in the probe inner diameter of 2 to 8 mm, the suction pressure of 100 to 450 mb, and the suction time of 1 to 10 seconds.

  In obtaining the regression equation of the parameter R0, it is preferable that the plurality of samples used for the regression analysis should have 20 or more healthy women. Further, when measuring the parameter R0 of these persons, it is preferable that these persons are acclimated for 10 to 60 minutes in a constant temperature and humidity chamber of 20 to 25 [deg.] C. and 40 to 60% RH. The measurement site is preferably a site where changes in the mechanical properties of the skin such as firmness appear greatly, and among them, the cheek or the like where the woman cares about the firmness of the skin is preferred. Moreover, it is preferable to obtain a regression equation for every measurement site.

  The regression equation of the parameter R0 can be obtained by linear regression analysis from the heart rate obtained as described above and the parameter R0. Once the regression equation is derived, the regression equation may be stored in an arithmetic unit that estimates the parameter R0 of the subject.

(2) Obtaining regression equation of parameter R0 and actual age In order to obtain the regression equation of parameter R0, the parameters R0 of the sample people are measured and the actual ages of these people are heard. From the age, a regression equation of the parameter R0 and the actual age is obtained. The actual age of the subject estimated by applying the subject parameter R0 in this regression equation is the age as seen from the mechanical characteristic value, and can be said to be the skin age as seen from the mechanical characteristic. Therefore, the regression formula between the parameter R0 and the actual age is a formula for calculating the skin age of the subject.

(3) Estimation of the subject's parameter R0 and calculation of the subject's skin age The heart rate in the daily life is obtained for the subject in the same manner as the heart rate when the regression equation of the parameter R0 is obtained, and the heart rate in the subject's daily life The subject's parameter R0 is estimated by fitting the number to the regression equation of the parameter R0. The subject parameter R0 can itself be used as an index of the aging change of the subject's skin, but the subject's skin age is further calculated by using the subject parameter R0 in the skin age calculation formula. May be.

  In addition, in order to calculate the skin age of the subject from the heart rate during the activities of the subject's daily life, a regression equation between the heart rate during the activities of daily life and the actual age is obtained, and the regression equation is used. The actual age of the subject may be estimated, and the estimated age may be used as the skin age of the subject. From the point of accuracy of regression, as described above, from the regression equation of the heart rate and the parameter R0 during activities of daily life It is preferable to calculate the skin age by estimating the parameter R0 of the subject and using the parameter R0 of the subject in a regression equation between the actual age and the parameter R0. In addition, since it is difficult to determine from what viewpoint the skin age of the subject calculated using the regression equation of the heart rate and the actual age is the skin age evaluated, the actual age and the parameter R0 It is preferable to calculate the skin age of the subject using the regression equation.

(4) Counseling of skin based on parameter R0 or skin age The counseling method of the present invention uses at least one of the parameter R0 of the subject estimated as described above or the skin age of the subject calculated as described above. This is a counseling method performed by a counselor such as a beauty staff or a beauty researcher in order to keep the skin age of a subject below the current level.

  The subject's parameter R0 and the subject's skin age may be obtained from the regression rate or calculation formula by the subject himself / herself through a communication line such as the Internet, and obtained from his / her heart rate using these formulas. In order to obtain appropriate skin counseling, the subject preferably transmits heart rate data in daily life to a counselor's personal computer, tablet, or the like.

  When the counselor receives heart rate data in the daily life of the subject, the counselor uses parameters such as a regression formula for parameter R0 or a calculation formula for skin age to store parameters from the received data. The heart rate used for the regression equation of R0 (for example, the maximum heart rate for each day) is extracted, and the average for the predetermined period is calculated. Then, it is preferable to estimate the subject parameter R0 from the average heart rate using the regression equation of the parameter R0, and further to calculate the skin age of the subject using the skin age calculation formula. In this case, for example, as shown in FIG. 2, a relationship diagram between the average of the highest heart rate and the parameter R0 is shown on the screen of the personal computer of the counselor, and the parameter R0 of the subject is estimated from the average of the highest heart rate of the subject. Further, as shown in FIG. 3, a relationship diagram between the parameter R0 and the actual age is shown as a relationship diagram between the parameter R0 and the skin age, and the skin age is derived from the estimated parameter R0 of the subject. It is preferable to show the skin age in an easy-to-understand manner to the subject.

  It is preferable that the counselor obtains the subject's actual age, information on the daily life situation, and the like from the subject as well as the heart rate data in the subject's daily life. In skin counseling, the skin age of the subject derived from the parameter R0 of the subject is compared with the actual age of the subject, for example, as shown in FIG. 4, and when the skin age is less than the actual age, It advises on lifestyle habits and skin care methods that are considered effective for maintaining age. On the other hand, when the skin age is higher than the actual age, advice is given on the lifestyle habits and skin care methods that are effective for making the skin age younger than the present age. If the activity data recorded by the activity meter that measured the heart rate data is received together with the heart rate data sent from the subject, the subject's activity amount, activity time, sleep time, etc. Therefore, it is preferable to give useful advice to keep the skin age below the present level including the improvement points.

Hereinafter, based on an Example, this invention is demonstrated concretely.
(1) Acquisition of the regression equation of parameter R0 In order to acquire the regression equation of parameter R0, the heart rate of daily life was recorded for 25 healthy women aged 25-35 years for 80 days. The parameter R0 was measured. In this case, the heart rate in daily life is always an activity meter with a heart rate measurement function (PULSENSE, manufactured by Epson), and for each person, the maximum heart rate during the daily activities is 4 weeks. The average was calculated.

  In the measurement of the parameter R0, a skin viscoelasticity measuring device (CUTOMETER MPA580, manufactured by Curage & Khazaka) was used, the skin measurement site was the cheek, the probe inner diameter was 2 mm, the suction pressure was 300 mb, and the suction time was 3 seconds. The maximum extension length (parameter R0) in the first suction when sucked was determined. In this case, each person was acclimated for 35 minutes in a constant temperature and humidity chamber at 22 ° C. and 50% RH.

The highest heart rate for each day is extracted from the heart rate data in daily life, the average of the highest heart rate for each day is calculated for 28 days, and the regression equation of this average and the parameter R0 obtained as described above is obtained. Asked. The results are shown in FIG. Further, when the correlation coefficient between the average of the maximum heart rate thus obtained and the parameter R0 is examined by changing the number of days for which the average of the maximum heart rate is changed, the correlation coefficient is obtained when the average number of days is 40 days or more. It was 0.70 or more.
Furthermore, as a result of obtaining a regression equation between the parameters R0 (y) and the actual age (x) of the 25 persons,
y = -316.53x + 103.53
The regression equation was obtained.

  On the other hand, for comparison, the relationship between the 28-day average of the above-mentioned 25 daily minimum heart rate (including resting time) and the parameter R0 was examined. The results are shown in FIG. There was no correlation between them.

  In addition, for these 25 persons, the water content of the cheek stratum corneum, which is the measurement site of the parameter R0, was measured using a water content measuring device (CORNEOMETER, manufactured by Curage & Khazaka), and the average and angle of the maximum heart rate described above The relationship with the layer moisture content was investigated. The results are shown in FIG. There was no correlation between them.

  From these results, it can be seen that the correlation between the average of the highest heart rate and the parameter R0 is extremely high. Further, since the parameter R0 has a correlation with the actual age, the age estimated from the parameter R0 using the regression equation of the parameter R0 and the actual age can be said to be the skin age from the viewpoint of the skin mechanical characteristic value.

Claims (5)

  Obtain a regression equation between the heart rate during activities of daily life and the maximum stretch length of the skin during suction (hereinafter referred to as parameter R0) measured by the skin viscoelasticity measuring device, and based on the regression equation, the subject A method for estimating the mechanical characteristics of the skin, which estimates the skin parameter R0 of the subject from the heart rate during activities of daily life.   The estimation method according to claim 1, wherein the heart rate is a maximum heart rate.   The estimation method according to claim 1 or 2, wherein a heart rate during an activity of daily life is an average of two or more weeks of a predetermined heart rate during an activity every day.   A regression equation between the parameter R0 and the actual age is obtained, and the regression equation is used as a skin age calculation formula. Based on the calculation formula, the subject parameter R0 estimated by the method according to any one of claims 1 to 3 The skin age calculation method of calculating the skin age of the subject from the above.   Using at least one of the parameter R0 of the subject estimated by the method according to any one of claims 1 to 3 and the skin age of the subject calculated by the method according to claim 4, the skin age is reduced to a current value for cosmetic purposes. A skin counseling method for counseling.

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