JP2019170750A - Gasket pressing tool for syringe and medical solution administration tool with the same - Google Patents

Abstract

To provide a gasket pressing tool for syringe which can reduce the time lag between an administration operation of a high-viscosity substance and an actual outflow of the high-viscosity substance, and timely administer the high-viscosity substance to a targeted site in a favorable manner.SOLUTION: The gasket pressing tool comprises an assembly 6 including a gasket pressing member 8, a syringe mounting member 4, and a plunger 5. The syringe mounting member 4 includes a barrel mounting part 40 capable of housing a flange 23 of a barrel 20. The barrel mounting part 40 comprises: a distal side support portion 71 for supporting a distal surface of the flange; a proximal side support portion 72 for supporting a proximal surface; a coupling portion 73 for coupling the distal side support portion and the proximal side support portion; and a flange housing portion 44 defined by the distal side support portion, the proximal side support portion, and the coupling portion.SELECTED DRAWING: Figure 23

Description

  TECHNICAL FIELD The present invention relates to a syringe gasket pressing tool and a drug solution administration tool including the same.

In order to discharge a relatively high-viscosity chemical solution from a syringe, a so-called screwed syringe configured to advance a plunger by screwing action of a screw has been proposed. As this type of injector, there is, for example, Japanese Patent Application Laid-Open No. 2008-167554 (Patent Document 1).
In the syringe of Patent Document 1, the syringe barrel 1 is fitted with a threaded flange 4 having a female thread 3, and the male thread 7 formed on the shaft portion 6 of the plunger 5 is screwed onto the female thread 3 of the threaded flange 4. In the syringe in which the click protrusion 9 is engaged with the axial groove 8 formed in the shaft portion of the plunger 5 every time the shaft portion 6 of the plunger 5 is rotated by a predetermined angle, on the outer peripheral side of the shaft portion 6 of the plunger 5. A movable piece 10 provided with a click projection 9 movably provided in the radial direction, and an axial direction formed on the shaft portion 6 of the plunger 5 by pressing and moving the movable piece 10 toward the shaft portion 6 side of the plunger 5. And a pressing piece 11 for engaging the click protrusion 9 with the groove 8.

The threaded flange 4 has slits 16 into which the flange 2 of the syringe barrel 1 is fitted at both ends, and the threaded flange 4 is engaged and integrated with the flange 2 by rotating the threaded flange 4 to a position overlapping the flange 2. It is detached from the flange 2 by rotating to a position where it intersects around 90 °.
A female screw 3 is formed at the center of the threaded flange 4, and a male screw 7 of the shaft portion 6 of the plunger 5 is screwed into the female screw 3. In the plunger 5, a gasket 18 is attached to the tip of the shaft portion 6, and the male screw 7 of the shaft portion 6 is screwed into the female screw 3 of the threaded flange 4. And the plunger 5 rotates the shaft part 6 of the plunger 5 by a predetermined angle by rotating the shaft part 6 of the plunger 5 via the handle 19 in a state where the threaded flange 4 is mounted on the flange 2 of the syringe barrel 1. The discharge is performed every time.

JP 2008-167554 A

Recently, endoscopic mucosal resection using local injection of highly viscous substances has been performed. As the highly viscous substance, hyaluronic acid, which is a drug, is generally used. As endoscopic mucosal resection, for example, partial resection of the inner wall of the digestive tract using an endoscope is performed.
In endoscopic mucosal resection, it is important to control the amount of hyaluronic acid injected. However, hyaluronic acid, which is a highly viscous substance, cannot be administered unless it is extruded under considerable pressure. Moreover, even if administration operation was performed, hyaluronic acid was not immediately administered in some cases.

When hyaluronic acid, which is a highly viscous substance, is administered using a syringe as in Patent Document 1, the plunger 5 is advanced by rotating the plunger 5, the gasket 18 is advanced, and the highly viscous substance is Discharged. The gasket 18 and the plunger 5 are pushed backward by the resistance when the highly viscous substance is pushed.
As a result of examination by the inventor of the present application, it has been found that the backward pressing force when the high-viscosity substance is pressed is applied to the connecting portion that houses the flange of the syringe barrel and deforms so as to expand the connecting portion. . It was found that the time lag between the administration operation and the actual outflow of the high-viscosity substance lies in the deformation of the connecting part, specifically, the high-viscosity substance does not flow out from the start of injection until the completion of the deformation of the connecting part. It was found that due to this time lag, the highly viscous substance could not be successfully administered to the target site.
The purpose of the present invention is to reduce the time lag between the administration operation of the high-viscosity substance and the actual outflow of the high-viscosity substance. Provided are a device and a drug solution administration device including the device.

What achieves the above object is as follows.
(1) A gasket pressing tool that is used by being attached to a syringe having a barrel having an annular flange at a base end, and a gasket that is slidable in the barrel and made of an elastic material,
The gasket pressing tool includes a gasket pressing member for pressing the gasket, a cylindrical syringe mounting member that movably houses the gasket pressing member and can be mounted on the base end of the barrel, and the syringe. A distal end portion enters the mounting member, and includes a plunger capable of pressing the gasket pressing member in the distal direction.
The plunger is provided at a distal end portion capable of pressing the gasket pressing member, a shaft portion extending in a proximal direction from the distal end portion and having a shaft-side threaded portion on an outer peripheral surface, and a proximal end portion of the shaft portion. A handle for rotating the plunger,
The syringe mounting member includes a barrel mounting portion that can store the flange of the barrel, and a cylindrical storage that can extend from the base end of the barrel mounting portion toward the base end of the gasket pressing tool and store the gasket pressing member. A cylindrical insertion portion that extends from the proximal end of the cylindrical storage portion in the proximal direction of the gasket pressing tool and through which the shaft portion of the plunger is inserted,
The insertion portion of the syringe mounting member has an insertion portion side screwing portion that is screwed with the shaft side screwing portion of the shaft portion on an inner peripheral surface,
The barrel mounting portion includes a distal end side support portion capable of supporting the distal end surface of the flange, a proximal end side support portion capable of supporting the proximal end surface of the flange, the distal end side support portion and the proximal end side support portion. Are formed by a connecting portion that connects the front end side support portion, the base end side support portion, and the connecting portion, and opens toward a side of the barrel mounting portion. And a flange insertion port for inserting the flange into the flange housing portion,
The distal side support part has an axial thickness of 5 to 25 mm along the central axis of the syringe mounting member, and the proximal side support part is 5 to 25 mm along the central axis of the syringe mounting member. A gasket pressing tool having a radial width of 1 to 5 mm along a radial direction of the syringe mounting member.

(2) In the above (1), the barrel mounting part has an outer peripheral surface extending along the central axis of the syringe mounting member from the distal end of the distal end side support part to the proximal end of the proximal end side support part. Gasket pressing tool.
(3) The gasket pressing tool according to (1) or (2), wherein the tip side support portion can support 55 to 80% of the tip surface of the flange.
(4) The barrel mounting portion has an opening that faces the flange insertion port with respect to the central axis of the syringe mounting member and into which a part of the flange stored in the flange storage portion can enter. The gasket pressing tool according to any one of (1) to (3).
(5) The insertion part of the syringe mounting member is disposed concentrically with the inner cylinder part having the insertion part side threaded part on the inner peripheral surface, outside the inner cylinder part and the inner cylinder part. (1) to (4) having a plurality of connecting plates intermittently arranged in the circumferential direction, connecting the outer cylinder portion, the outer peripheral surface of the inner cylinder portion, and the inner peripheral surface of the outer cylinder portion. The gasket pressing tool in any one.
(6) The gasket pressing tool according to (5), wherein the plurality of connecting plates are arranged at 4 to 10 equal intervals in the circumferential direction of the syringe mounting member.
(7) The gasket pressing tool according to (6), wherein the syringe mounting member has a substantially uniform outer diameter from a distal end of the cylindrical storage portion to a proximal end of the outer cylindrical portion of the insertion portion.
(8) The gasket pressing tool according to any one of (1) to (7), wherein the cylindrical storage portion has an outer diameter smaller than an outer diameter of the base end side support portion of the barrel mounting portion.
(9) The gasket pressing tool according to (8), wherein the cylindrical housing portion has a curved portion that is enlarged in diameter toward a distal end and connected to a proximal end of the proximal end side support portion of the barrel mounting portion. .
(10) The gasket pressing tool according to (9), wherein the curved portion has a radius of curvature of 0.3 to 3.
(11) The syringe mounting member according to any one of (1) to (10), wherein the syringe mounting member includes a barrel support portion that extends in a distal direction from the flange housing portion and supports an outer peripheral surface of the cylindrical portion of the barrel. Gasket pressing tool.

Moreover, what achieves the said objective is as follows.
(12) From the gasket pressing tool according to any one of the above (1) to (11), the syringe, a chemical solution filled in the syringe, and a sealing member that seals the tip of the barrel. A drug administration device.

The gasket pressing tool of the present invention is used by being attached to a syringe provided with a barrel having an annular flange at the base end and a gasket that is slidable within the barrel and made of an elastic material. The gasket pressing tool includes a gasket pressing member for pressing the gasket, a cylindrical syringe mounting member that can be movably accommodated in the gasket pressing member and can be mounted on the proximal end of the barrel, and a distal end portion in the syringe mounting member. And a plunger that can press the gasket pressing member in the distal direction. The plunger rotates the plunger provided at the proximal end of the shaft portion, the distal end portion capable of pressing the gasket pressing member, the shaft portion extending from the distal end portion in the proximal direction and having the shaft-side threaded portion on the outer peripheral surface. And a handle for operation. The syringe mounting member includes a barrel mounting portion that can store the flange of the barrel, a cylindrical storage portion that extends from the proximal end of the barrel mounting portion in the proximal direction of the gasket pressing tool, and can store the gasket pressing member, and a cylindrical storage A cylindrical insertion portion that extends from the proximal end of the portion in the proximal direction of the gasket pressing tool and through which the shaft portion of the plunger is inserted. The insertion portion of the syringe mounting member has an insertion portion side screwing portion that engages with the shaft side screwing portion of the shaft portion on the inner peripheral surface, and the barrel mounting portion supports the tip end surface that can support the tip surface of the flange. A base end side support portion capable of supporting the base end face of the flange, a connecting portion connecting the tip end side support portion and the base end side support portion, a tip end side support portion, a base end side support portion and a connecting portion; And a flange accommodating portion that can accommodate the flange, and a flange insertion opening that opens toward the side of the barrel mounting portion and for inserting the flange into the flange accommodating portion. The distal side support portion has an axial thickness of 5 to 25 mm along the central axis of the syringe mounting member, and the proximal side support portion has an axial thickness of 5 to 25 mm along the central axis of the syringe mounting member. The connecting portion has a radial width of 1 to 5 mm along the radial direction of the syringe mounting member.
In this chemical solution discharge tool, the barrel mounting portion connects the distal end side support portion having the above thickness, the proximal end side support portion having the above thickness, and the distal end side support portion and the proximal end side support portion. Since the flange housing portion having the connecting portion having the above-described thickness is provided, the connecting portion is hardly deformed so as to be widened even when a rearward pressing force is applied. For this reason, the time lag between the administration operation of the highly viscous substance and the actual outflow of the administration substance is small, and the administration substance can be administered to the target site with good timing and good.

Moreover, the chemical | medical solution administration tool of this invention consists of said chemical | medical solution discharge tool, the chemical | medical solution with which the inside of the syringe was filled, and the sealing member which seals the front-end | tip part of a barrel.
For this reason, since the liquid medicine administration device of the present invention uses the liquid medicine discharge device described above, there is little time lag between the administration operation of the highly viscous substance and the actual outflow of the administration substance, and the administration substance is timed to the target site. It can be administered well and well.

FIG. 1 is a front view of a drug solution administration device according to an embodiment of the present invention. 2 is a cross-sectional view taken along line AA in FIG. FIG. 3 is a front view of a gasket pressing tool for a syringe according to an embodiment of the present invention to which a syringe is attached. FIG. 4 is a left side view of the syringe gasket pressing tool shown in FIG. 3. 5 is an enlarged bottom view of the syringe gasket pressing tool shown in FIG. 6 is an enlarged sectional view taken along line BB in FIG. 7 is a cross-sectional view taken along the line CC of FIG. 8 is a cross-sectional view taken along the line DD of FIG. 9 is a perspective view of the syringe gasket pressing tool shown in FIG. FIG. 10 is an explanatory diagram for explaining the components used in the syringe gasket pressing tool shown in FIG. 3. FIG. 11 is a front view of a gasket pressing assembly used in the syringe gasket pressing tool shown in FIG. 12 is a bottom view of the gasket pressing assembly shown in FIG. 13 is a cross-sectional view taken along line EE in FIG. 14 is a front view of a gasket pressing member used in the gasket pressing assembly shown in FIG. 15 is a cross-sectional view taken along line FF in FIG. FIG. 16 is a bottom view of the gasket pressing member shown in FIG. FIG. 17 is a perspective view of the gasket pressing member shown in FIG. 14 as viewed obliquely from below. 18 is a front view of a sound generating member used in the gasket pressing assembly shown in FIG. 19 is a bottom view of the sound generating member shown in FIG. 20 is a cross-sectional view taken along line GG in FIG. FIG. 21 is a side view of the left side view of the syringe mounting member used in the syringe gasket pressing tool shown in FIG. 3. FIG. 22 is a bottom view of the syringe mounting member in the state shown in FIG. 23 is a cross-sectional view taken along line HH in FIG. 24 is a cross-sectional view taken along the line II of FIG. FIG. 25 is a reference view of the syringe mounting member of FIG. FIG. 26 is a diagram for explaining the end surface of the QQ line in FIG. 25. FIG. 27 is an explanatory diagram of the end surface of line PP in FIG. FIG. 28 is an explanatory diagram of an end surface taken along the line RR in FIG. FIG. 29 is a perspective view of the gasket pressing member in the state shown in FIG. 21 as viewed from the front end side. 30 is a perspective view of the gasket pressing member in the state shown in FIG. 22 as viewed from the base end side. FIG. 31 is an enlarged front view of a plunger used in the syringe gasket pressing tool shown in FIG. 3. FIG. 32 is a left side view of the plunger shown in FIG. 33 is an enlarged perspective view of the distal end portion of the plunger shown in FIG. FIG. 34 is an explanatory cross-sectional view for explaining the sound generating mechanism of the present invention. FIG. 35 is a cross-sectional view for explaining the sound generating mechanism of the present invention. FIG. 36 is an explanatory sectional perspective view for explaining the sound generation mechanism of the present invention. FIG. 37 is an explanatory cross-sectional view for explaining the sound generation mechanism of the present invention. FIG. 38 is an explanatory cross-sectional view for explaining the sound generation mechanism of the present invention. FIG. 39 is a front view of a gasket pressing tool for a syringe according to another embodiment of the present invention to which a syringe is attached. 40 is a longitudinal sectional view of the syringe gasket pressing tool shown in FIG. 39. FIG. 41 is a perspective view of the syringe gasket pressing tool shown in FIG. 39. FIG. FIG. 42 is a side view of the left side view of the syringe mounting member used in the syringe gasket pressing tool shown in FIG. 43 is a bottom view of the syringe mounting member in the state shown in FIG. 44 is a cross-sectional view taken along line JJ of FIG. 45 is a cross-sectional view taken along the line KK of FIG. FIG. 46 is a left side view of the syringe mounting member in the state shown in FIG. 47 is a perspective view of the gasket pressing member in the state shown in FIG. 42 as viewed from the front end side. FIG. 48 is a perspective view of the gasket pressing member in the state shown in FIG. 42 as viewed from the base end side. 49 is an enlarged longitudinal sectional view of a gasket pressing assembly used in the syringe gasket pressing tool shown in FIG. FIG. 50 is an explanatory diagram for explaining components of the gasket pressing assembly used in the syringe gasket pressing tool shown in FIG. 39. 51 is an enlarged bottom view of the gasket pressing member used in the syringe gasket pressing tool shown in FIG. 39. FIG. 52 is an enlarged plan view of a joint member used in the syringe gasket pressing tool shown in FIG. 39. FIG. 53 is an enlarged front view of a plunger used in the syringe gasket pressing tool shown in FIG. 54 is an enlarged view of the distal end portion of the plunger shown in FIG. FIG. 55 is a longitudinal sectional view of a drug solution administration device according to another embodiment of the present invention. FIG. 56 is an explanatory diagram for explaining a treatment method using the drug administration device of the present invention. FIG. 57 is an explanatory diagram for explaining a treatment method using the drug administration device of the present invention. FIG. 58 is an explanatory diagram for explaining a treatment method using the drug administration device of the present invention. FIG. 59 is an explanatory diagram for explaining a treatment method using the drug administration device of the present invention. FIG. 60 is an explanatory diagram for explaining a treatment method using the drug administration device of the present invention.

DESCRIPTION OF THE PREFERRED EMBODIMENTS A syringe gasket pressing device and a drug solution administration device according to the present invention will be described with reference to embodiments shown in the drawings.
The drug administration device 1 of the present invention is a prefilled syringe having a syringe gasket pressing tool 3, a barrel 20, a drug solution 11 filled in the barrel 20, and a gasket 7 slidably accommodated in the barrel 20. 2 and the prefilled syringe 2 is mounted on the barrel mounting portion 40 of the syringe gasket pressing tool 3.

The syringe gasket pressing tool 3 of the present invention is used by being mounted on a syringe having a barrel 20 having an annular flange 23 at a proximal end and a gasket 7 slidably accommodated in the barrel 20.
The syringe gasket pressing tool 3 includes a gasket pressing member 8 for pressing the gasket 7, a gasket pressing member 8 that is movably housed, and a cylindrical syringe mounting member 4 that can be mounted on the base end of the barrel 20. The plunger 5 is provided with a distal end portion entering the syringe mounting member 4 and capable of pressing the gasket pressing assembly 6 by rotation.

  The plunger 5 is provided at a distal end portion that can press the gasket pressing member 8, a shaft portion 51 that extends in the proximal direction from the distal end portion and has a shaft-side threaded portion 55 on the outer peripheral surface, and a proximal end portion of the shaft portion 51. And a handle 52 for rotating the plunger.

  The syringe mounting member 4 has a barrel mounting portion 40 that can store the flange 23 of the barrel 20 and a cylindrical storage that extends from the base end of the barrel mounting portion 40 toward the base end of the gasket pressing tool 3 and can store the gasket pressing member. And a cylindrical insertion portion 47 that extends from the proximal end of the cylindrical storage portion 42 toward the proximal end of the gasket pressing tool 3 and into which the shaft portion 51 of the plunger 5 is inserted. The insertion portion 47 of the syringe mounting member 4 has an insertion portion side screwing portion 46 that is screwed with the shaft side screwing portion of the shaft portion 51 on the inner peripheral surface.

  The barrel mounting portion 40 can support the distal end side support portion 71 capable of supporting the distal end surface of the flange 23 (in other words, capable of contacting the distal end surface of the flange 23) and the proximal end surface of the flange 23 (in other words, the flange 23). The base end side support portion 72, the tip end side support portion 71 and the base end side support portion 72, the tip end side support portion 71, and the base end side support portion 72. And a flange accommodating portion 44 that is formed by the connecting portion 73 and can accommodate the flange 23, and opens toward the side of the barrel mounting portion 40, and a flange insertion port 43 for inserting the flange into the flange accommodating portion 44. Is provided.

  The distal end side support portion 71 has an axial thickness (N) of 5 to 25 mm along the central axis of the syringe mounting member 4, and the proximal end side support portion 72 is along the central axis of the syringe mounting member 4. And an axial thickness (M) of 5 to 25 mm. Further, the connecting portion 73 has a radial width (T) of 1 to 5 mm along the radial direction of the syringe mounting member 4.

1 and 2 includes a prefilled syringe 2 and a gasket pressing tool 3 to which the prefilled syringe 2 is attached.
As shown in FIG. 2, the prefilled syringe 2 seals the barrel 20, the chemical solution 11 filled in the barrel 20, the gasket 7 slidably accommodated in the barrel 20, and the tip of the barrel 20. A sealing member (seal cap) 21 is provided, and a so-called plunger is not provided. The barrel 20 includes a nozzle 22 for discharging a chemical solution at the tip and a collar portion 24 provided so as to enclose the nozzle, and a flange 23 protruding outward at the rear end.

As shown in FIGS. 1 to 9, the drug solution administration device 1 has a gasket pressing device 3. 3 and 4 to 6, the gasket pressing assembly 6 is attached to a gasket 7.
The gasket pressing tool 3 includes a gasket pressing assembly 6, a plunger 5 for pressing it from the rear, and a syringe mounting member 4 for mounting the gasket pressing assembly 6 and the plunger 5 to the syringe 2.

  1 and 2, the gasket pressing assembly 6 is located behind the gasket 7 and is not attached to the gasket 7. In use, the plunger 5 is rotated and moved forward, whereby the gasket pressing assembly 6 is mounted on the gasket 7 as shown in FIGS. 3, 4 to 6. The gasket pressing assembly 6 can also be called a gasket mounting member. In FIG. 3 and subsequent figures, the syringe 2 omits the chemical solution and the seal cap.

  The syringe mounting member 4 includes a barrel mounting portion 40 as shown in FIGS. 1 to 9 and 21 to 30, and in particular, as shown in FIGS. 2 and 7, the gasket pressing assembly 6 can be moved. It is stored in.

  As shown in FIGS. 21 to 24, 29, and 30, the syringe mounting member 4 includes a distal end side support portion 71, a proximal end side support portion 72, a connection portion 73, a flange storage portion 44, and a flange insertion port 43. ing. The front end side support portion 71 can contact the front end surface of the flange 23 of the barrel 20 housed in the flange housing portion 44, and supports the front end surface of the flange 23.

  In the syringe mounting member 4 of this embodiment, the distal end side support portion 71 has a predetermined thickness (axial thickness: N) extending along the central axis of the syringe mounting member 4 as shown in FIGS. The thickness (N) is preferably 5 to 25 mm, and particularly preferably 10 to 15 mm.

  Further, in this embodiment, the distal end side support portion 71 has a shape and an area as shown in FIG. 26 which is a reference view showing the end surface of the line QQ in FIG. For this reason, as shown in FIG. 26, it can contact | abut with the flange 23 with a certain amount of area. For this reason, the front end side support part 71 can fully support the front end surface of the flange. As the front end side support portion 71, it is preferable that 55 to 80% of the front end surface 23a of the flange 23 can be supported (in other words, 55 to 80% of the front end surface 23a can be contacted). % Can be supported (can contact 70 to 80%).

  Further, in the syringe mounting member 4 according to this embodiment, the proximal end support portion 72 has a predetermined thickness (axial thickness: M) extending along the central axis of the syringe mounting member 4 as shown in FIGS. The thickness (M) is preferably 5 to 25 mm, particularly preferably 10 to 15 mm.

  Further, in this embodiment, the base end side support portion 72 has a shape and an area as shown in FIG. 28 which is a reference view showing the end surface of the RR line in FIG. For this reason, as shown in FIG. 28, it can contact substantially the entire base end face 23b of the flange 23. For this reason, the base end side support part 72 can fully support the base end face of the flange.

  In the syringe mounting member 4 of this embodiment, the distal end side support portion 71 and the proximal end side support portion 72 are connected by a connecting portion 73. And the connection part 73 is provided with the predetermined | prescribed thickness (axial direction thickness: L) extended along the central axis of the syringe mounting member 4, as shown in FIG. 23 thru | or FIG. 25, As thickness (L), The thickness of the flange 23 of the barrel 20 is preferably −1 to 1 mm, and in particular, the thickness of the flange 23 of the barrel 20 is preferably −0.5 to 0.5 mm.

  Further, in this embodiment, the connecting portion 73 has a shape and an area as shown in FIG. 27 which is a reference view showing the PP line end face of FIG. 25, and there are two connecting portions 73 facing each other. Moreover, the connection part 73 is provided with the radial direction width | variety T along the radial direction of the syringe mounting member 4, as shown in FIG.25 and FIG.27. The radial width (T) is preferably 1 to 5 mm, and particularly preferably 2 to 3 mm.

  The syringe mounting member 4 of this embodiment includes a flange storage portion 44 formed (defined) by a distal end side support portion 71, a proximal end side support portion 72 and a connecting portion 73. The flange storage portion 44 opens toward the side of the barrel mounting portion 40 and faces the flange insertion port 43 for inserting the flange into the flange storage portion 44 and the flange insertion port 43 (the barrel mounting portion 44). And an opening 48 through which a part of the flange housed in the flange housing part can enter.

  In particular, the flange housing portion 44 of the syringe mounting member 4 according to this embodiment has a slit in which the flange 23 of the syringe 2 can be inserted from one long diameter side (in other words, vertically inserted), as shown in FIGS. It is formed by. For this reason, in the state where the syringe 2 is mounted on the syringe mounting member 4, one long diameter portion of the flange 23 of the syringe 2 and the two short diameter portions facing each other are accommodated in the syringe mounting member 4, The long diameter portion is exposed.

  In addition, one end of the long diameter portion of the flange housed in the syringe mounting member 4 is slightly exposed from the opening 48 facing the flange insertion port 43. In this embodiment, the flange storage portion 44 is formed by a vertically long U-shaped slit.

  In the syringe mounting member 4 of this embodiment, as shown in FIGS. 21 to 24, 29, and 30, the barrel mounting portion 40 is connected from the distal end of the distal end side support portion 71 to the proximal end of the proximal end side support portion 72. And has an outer peripheral surface (outer wall) extending along the central axis of the syringe mounting member. Specifically, the outer peripheral surface (outer wall portion) has a semi-polygonal cylindrical shape with the flange insertion port 43 portion missing.

  In the syringe mounting member 4 of this embodiment, as shown in FIGS. 21 to 24, 29 and 30, the syringe mounting member 4 extends in the distal direction from the flange housing portion 40, and has a cylindrical portion of the barrel 20. A barrel support 41 for supporting the outer peripheral surface is provided. The barrel support part 41 is formed by a substantially half-cylinder part extending from the barrel mounting part 40 (flange storage part 44) to the distal end side.

  In the syringe mounting member 4 of this embodiment, as shown in FIGS. 21 to 24, 29, and 30, the syringe mounting member 4 extends from the base end of the barrel mounting portion 40 to the base end direction of the gasket pressing tool 3. A cylindrical storage portion 42 that can store the gasket pressing member, and a cylindrical shape that extends from the proximal end of the cylindrical storage portion 42 toward the proximal end of the gasket pressing tool 3 and into which the shaft portion 51 of the plunger 5 is inserted. And an insertion portion 47.

  The cylindrical storage portion 42 is a cylindrical portion that extends rearward from the base end of the barrel mounting portion 40. The cylindrical storage portion 42 includes a storage portion for the gasket pressing assembly therein. The cylindrical storage portion 42 extends in the proximal direction with an outer diameter smaller than the outer diameter of the proximal end side support portion 72 of the barrel mounting portion 40.

  Furthermore, in the syringe mounting member 4 of this embodiment, as shown in FIGS. 21 to 24, the cylindrical storage portion 42 is enlarged in diameter toward the distal end, and the proximal end of the proximal side support portion of the barrel mounting portion 40. It has the curved part 75 connected with. The curved portion 75 is formed in an annular shape. The curvature radius of the curved portion 75 is preferably 0.3 to 3 mm, and particularly preferably 0.5 to 1.5 mm.

  Furthermore, the syringe mounting member 4 of this embodiment includes a cylindrical insertion portion 47 that extends from the proximal end of the cylindrical storage portion 42 in the proximal direction of the gasket pressing tool 3 and into which the shaft portion 51 of the plunger 5 is inserted. . The shaft portion 51 of the plunger 5 includes a shaft side screwing portion 55, and an insertion portion side screwing portion 46 that is screwed with the shaft side screwing portion 55 is provided on the inner peripheral surface of the insertion portion 47. In this embodiment, the shaft side screwing portion 55 is a spiral groove, and the insertion portion side screwing portion 46 is a spiral rib, specifically, a short spiral rib.

  Further, as shown in FIG. 30, the insertion portion 47 includes an inner cylinder portion 77 provided with the insertion portion side screwing portion (short spiral rib) 46 and an outer side of the inner cylinder portion 77 (in other words, an inner cylinder). The outer cylindrical portion 76 that is concentrically arranged with the inner cylindrical portion 77, and the outer peripheral surface of the inner cylindrical portion 77 and the inner peripheral surface of the outer cylindrical portion 76, It has a plurality of connecting plates 78 arranged intermittently in the circumferential direction. It is preferable that 4-10 sheets of the plurality of connecting plates 78 are arranged at equal intervals in the circumferential direction of the syringe mounting member 4. In this embodiment, the connecting plate 78 extends over the entire length of the inner cylinder portion 77. For this reason, the insertion part 47 which is a site | part screwed with the plunger 5 is firmly reinforced, and it prevents that the distortion | strain arises in the syringe mounting member 4 in the said part. In addition, the syringe mounting member 4 of this embodiment has a substantially uniform outer diameter from the distal end of the cylindrical storage portion 42 to the proximal end of the outer cylindrical portion 76 of the insertion portion 47.

  As shown in FIGS. 10 to 13, the gasket pressing assembly 6 in the syringe gasket pressing tool 3 of this embodiment includes a gasket pressing member 8 and a sound generating member 9 attached to the gasket pressing member 8. . As shown in FIGS. 14 to 17, the gasket pressing member 8 enters the gasket 7 and contacts the gasket inner surface 80, and the flange portion 81 formed at the rear portion of the gasket inlet portion 80. And a cylindrical portion 82 extending rearward from the flange portion 81.

  The in-gasket entry portion 80 includes a tip closing portion and a tapered diameter-reducing portion extending from the flange portion 81 to the rear end of the tip closing portion. Further, the gasket pressing member 8 includes two deformable portions 83 provided on the cylindrical portion 82 and facing each other, and an engagement window portion 84 provided in each deformable portion. The deformable portion 83 and the engaging window portion 84 form an engaging portion with the sound generating member 9.

  Furthermore, as shown in FIGS. 10 to 17, the gasket pressing member 8 includes a sound generating member storage portion, axially extending wall portions 88 and 89, a plunger abutting portion 62, and a columnar recess 85. It has. As shown in FIG. 16, a central part is provided with a cylindrical part having a columnar concave part 85, and four partition parts extending laterally from the cylindrical part are provided. In the gasket pressing member 8, four partitions are formed with four axially extending spaces. The wall portions 88 and 89 are formed by two partitioning portions facing each other with a slight shift from the central axis of the cylindrical portion formed inside the gasket pressing member. The plunger contact portion 62 is formed by a rear end surface of a cylindrical portion having a columnar recess 85. The columnar recess 85 is a cylindrical recess.

  As shown in FIGS. 10 to 13 and FIGS. 18 to 20, the sound generating member 9 includes a cylindrical main body 91 and elastically deformable claws 92 and 93 that protrude in the distal direction from the inner surface of the cylindrical main body. And an enlarged diameter cylindrical portion 90 extending downward from the cylindrical main body portion 91. In this embodiment, two claw portions 92 and 93 are provided, and the toe portions 92a and 93a are substantially opposed to each other.

  The sound generating member 9 includes claw portions 92 and 93 that are elastically deformable (specifically, elastically deformable in the circumferential direction of the gasket pressing member 8). The gasket pressing member 8 includes wall portions 88 and 89 that abut (specifically, abut and press) the claw portions 92 and 93. The claw portions 92 and 93 include toe portions 92 a and 93 a protruding from the wall portions 88 and 89. The plunger 5 includes a claw flip rib 54 provided on the side surface of the tip.

  In a state where the plunger 5 (specifically, the tip end portion) does not come into contact with the gasket pressing assembly 6 so as to be able to press, the claw flipping rib 54 is positioned behind the toe portions 92a and 93a, and the plunger 5 (specifically, In the state in which the tip portion is in contact with the gasket pressing assembly 6 so that the gasket pressing assembly 6 can be pressed, the claw repelling rib 54 is positioned on the side of the toe portions 92a and 93a. As the gasket pressing assembly 6 moves forward, the claw repelling rib 54 abuts against the toe portions 92a, 93a, deforms and passes the claw portions 92, 93, and is restored after the passage. Due to the abutment of the wall portions 88 and 89, sound is generated.

The claw portions 92 and 93 are base portions 92c and 93c connected to the inner surface of the distal end portion of the cylindrical main body portion 91, curved portions 92b and 93b protruding forward from the base portion 93c, and free ends facing the rear end direction. Toe portions 92a and 93a are provided. The tip portions of the claw portions 92 and 93 are constituted by curved portions 92b and 93b. The toe portions 92a and 93a and the base portions 93c and 93c are substantially opposed to each other.
Furthermore, in this embodiment, the toe portions 92 a and 93 a are located in the cylindrical main body portion 91. The claw portions 92 and 93 are elastically deformable, specifically, bendable in a direction in which the toe portions 92a and 93a approach the base portions 93c and 93c. Moreover, the edge part of the toe | tip part 92a, 93a is located in the rear-end side rather than the base parts 93c and 93c.

  The enlarged diameter cylindrical portion 90 includes two deformable portions 63 facing each other and engaging ribs 94 provided on each deformable portion 63. The sound generating member 9 is attached to the gasket pressing member 8 by the engagement rib 94 of the sound generating member 9 engaging with the engaging window portion 84 of the gasket pressing member 8. Further, the enlarged diameter cylindrical portion 90 is provided with a side rib 95, and the side rib 95 enters the two recessed portions 61 provided on the inner surface of the cylindrical portion 82 of the gasket pressing member 8. For this reason, the rotation of the sound generating member 9 within the gasket pressing member 8 is restricted.

  As shown in FIG. 13, in the gasket pressing assembly 6, the tip portion of the toe portion 93 a of the sound generating member 9 is positioned rearward (in other words, protruding) from the lower end of the wall portion 89 of the gasket pressing member 8. )is doing. Similarly, the tip end portion of the toe portion 92a of the sound generating member 9 is also positioned rearward (in other words, protruding) from the lower end of the wall portion 88 of the gasket pressing member 8.

  Further, as shown in FIG. 12, the side portions on the toe side of the claw portions 92 and 93 of the sound generating member 9 abut against the wall portion of the gasket pressing member 8 and press the partition wall, and slightly in the directions of the base portions 92c and 93c. Is curved (elastically deformed). Further, the claw portions 92 and 93 are accommodated in the gasket pressing member 8 in the space portions 86 and 87 divided by the partition portion.

  In this embodiment, as shown in FIGS. 20, 35, and 36, the toe portions 92a and 93a are tapered. Surfaces facing the wall portions 88 and 89 of the toe portions 92a and 93a (surfaces that come into contact with the nail repelling rib 54 when the plunger 5 described later rotates in the screwing progress direction) are flat surfaces. Further, the flat surfaces of the toe portions 92 a and 93 a that are in contact with the nail flip ribs 54 are substantially parallel to the central axis of the sound generating member 9.

  Further, the surfaces of the toe portions 92a and 93a on the base portions 92c and 93c side (surfaces to which the fingernail ribs 54 may come into contact when the plunger 6 described later rotates in the screwing backward direction) are directed toward the tip. The inclined surface is further away from 92a and 93a. Further, as shown in FIG. 20, the claw portions 92, 93 extend upward from the base portions 92c, 93c, bend in a U shape at the curved portions 92b, 93b, and the toe portions 93a, 93a are in the rear end direction. It becomes the free end that faces. Furthermore, the predetermined length curved portion side is formed to be slightly thicker than the other portions from the toe portions 92a and 93a. The claw portions 92 and 93 have a rectangular cross section throughout.

As shown in FIGS. 2 to 8, 10, and 31 to 33, the plunger 5 is capable of entering the syringe mounting member 4 and pressing the gasket pressing assembly 6. Specifically, the plunger 5 includes a shaft portion 51 and a handle 52 provided at the rear end portion of the shaft portion 51.
The shaft portion 51 includes a shaft-side threaded portion (spiral groove) 55 into which an insertion portion-side threaded portion (spiral rib) 46 of the syringe mounting member 4 enters the outer surface so as to be able to proceed with screwing, and a side surface of the tip portion. A plurality of nail flip ribs 54 are provided. When the plunger 5 is rotated to one side (forward rotation), the tip part advances in the syringe mounting member, and when the plunger 5 is rotated to the other side (reverse rotation), the tip part is moved within the syringe mounting member. ,fall back.

  Specifically, as shown in FIGS. 32 and 33, the tip of the shaft portion 51 has an annular contact formed by a tip base 57 having a claw repelling rib 54 on the outer surface and a tip of the tip base. A contact portion 56 and a columnar protrusion portion 53 that protrudes from the distal end base portion 57 and has a smaller diameter than the outer diameter of the contact portion are provided. The columnar protrusion 53 can enter and rotate after entering the columnar recess 85 (specifically, the columnar recess) formed at the center of the gasket pressing member 8.

  As shown in FIGS. 6, 33, and 34, the claw repelling ribs 54 are provided in an odd number of three or more, and the claw repelling ribs 54 are equiangular with the central axis of the plunger 5. It is preferable to arrange | position. In this embodiment, five claw flipping ribs 54 are provided and are arranged at an equal angle with respect to the central axis of the plunger 5.

  Further, in this embodiment, when the plunger 5 rotates in the screwing advance direction, the surface of the claw repelling rib 54 that contacts the toe portions 92a, 93a is formed substantially parallel to the central axis of the plunger 5, and From the outer peripheral surface of the distal end base portion 57, the surface is almost upright. Furthermore, the surface of the nail flip rib 54 opposite to the above-described standing surface is an inclined surface. For this reason, the claw flipping rib 54 is thicker in the downward direction (toward the distal end base portion 57).

   The handle 52 is formed at the rear end portion of the shaft portion 51, and is formed by two projecting portions extending in the radial direction from the shaft portion 51. The plunger 5 of this embodiment includes an end portion that extends rearward from the handle portion 52.

  As shown in FIG. 8 and FIG. 35, which is an enlarged view thereof, in a state where the annular abutting portion 56 of the plunger 5 abuts the plunger abutting portion 62 of the gasket pressing assembly 6 so that it can be pressed, 54 is located on the side of the toe portions 92a and 93a. The plunger 5 is advanced by the rotation of the plunger 5 and the gasket pressing assembly 6 is advanced. At the same time, the claw repelling rib 54 abuts on the toe portions 92a and 93a and deforms and passes the claw portions 92 and 93. At the same time, the sound is generated by the contact of the claw portions 92 and 93 with the wall portions 88 and 89 restored after the passage.

  And in the gasket pressing tool 3 for syringes and the chemical | medical solution administration tool 1 of this Example, the annular contact part 56 of the plunger 5 contact | abutted so that the assembly 6 for gasket pressing could be pressed by rotating a plunger. The state, that is, the state shown in FIGS. 35 and 36 is obtained. In this state, the claw repelling rib 54 of the plunger 5 is located on the side of the toe portions 92a and 93a. Then, by rotating the plunger 5, the plunger 5 advances and the gasket pressing assembly 6 also advances. As the gasket pressing assembly 6 advances, the gasket 7 also advances. Then, as shown in FIG. 37, the claw repelling rib 54 of the plunger 5 abuts on the toe portions 92a and 93a of the sound generating member 9, deforms the claw portions 92 and 93, and eventually passes. Then, after passing, the claw portions 92 and 93 are restored to their original shapes due to their spring properties, and at the time of restoration, the claw portions 92 and 93 come into contact with the wall portions 88 and 89 to generate sound.

  In particular, in the illustrated embodiment, the wall portion 88 includes a thin rear end portion 88a, and the restored toe portion 92a is in contact with the thin rear end portion 88a. A relatively high sound is generated because the rear end of the thin wall is thin. In this embodiment, two claw portions 92 and 93 and five claw flipping ribs 54 are provided. For this reason, when the plunger 5 rotates, 10 collision sounds are produced. In other words, every time the plunger 5 rotates 36 degrees, a collision sound is generated.

  Then, in the syringe gasket pressing tool 3 of this embodiment, as shown in FIG. 38, when the contact portion 56 of the plunger 5 does not contact the gasket pressing assembly 6 so as to be able to press it, the nail flipping of the plunger 5 is performed. The rib 54 is located behind the toe portions 92a and 93a of the sound generating member 9. For this reason, even if the plunger 5 is rotated, the claw flipping rib 54 does not come into contact with the toe portions 92a and 93a, so that no sound is generated. In the state shown in FIGS. 35 and 34, the plunger 5 is moved backward by rotating the plunger 5 backward (rotating in the backward direction). Even during this reverse rotation, no sound is generated. In addition, the drug administration device 1 of this embodiment is provided with the gasket pressing assembly 6 attached to the gasket 7 as shown in FIG. 7, in other words, the state is the initial state. It may be. The plunger 5 may or may not be in contact with the gasket pressing assembly 6.

Next, the drug solution administration device 1a and the syringe gasket pressing device 3a of the embodiment shown in FIGS. 39 to 41 will be described.
The chemical solution administration tool 1a and gasket pressing tool 3a of this embodiment and the above-described chemical solution administration tool 1a and gasket pressing tool 3a have the same configuration relating to sound generation, and the differences are the form of the syringe mounting member, gasket pressing This is the structure of the assembly. The same parts are denoted by the same reference numerals, and the above description is referred to.

  As shown in FIGS. 39 to 47, the syringe mounting member 4a used in the gasket pressing tool 3a of this embodiment includes a barrel mounting portion 40a. As shown in FIGS. 39 to 48, the syringe mounting member 4a includes a syringe mounting member 4a, and similarly accommodates the gasket pressing assembly 6a, as shown in FIG.

  As shown in FIGS. 41 to 48, the syringe mounting member 4a includes a distal end side support portion 71a, a proximal end side support portion 72a, a connecting portion 73a, a flange storage portion 44a, and a flange insertion port 43a. The front end side support portion 71a can contact the front end surface of the flange 23 of the barrel 20 housed in the flange housing portion 44a, and supports the front end surface of the flange 23.

  In the syringe mounting member 4a of this embodiment, as shown in FIG. 44, the distal end side support portion 71a has a predetermined thickness (axial length: V) extending along the central axis of the syringe mounting member 4a. (V) is preferably 5 to 25 mm, and particularly preferably 10 to 15 mm. The distal end side support portion 71a can sufficiently support the distal end surface of the flange. As the front end side support portion 71a, it is preferable to be able to support 55 to 80% of the front end surface 23a of the flange 23 (in other words, to be able to contact 55 to 80% of the front end surface 23a). % Can be supported (can contact 70 to 80%).

  In the syringe mounting member 4a of this embodiment, the proximal end support portion 72a has a predetermined thickness (axial length: U) extending along the central axis of the syringe mounting member 4a, as shown in FIG. In addition, the thickness (U) is preferably 5 to 25 mm, and particularly preferably 10 to 15 mm. The base end side support portion 72a can be brought into contact with substantially the entire base end surface 23b of the flange 23. For this reason, the base end side support part 72a can fully support the base end face of the flange.

  And in this Example syringe mounting member 4a, the front end side support part 71a and the base end side support part 72a are connected by the connection part 73a. And the connection part 73a is provided with the predetermined | prescribed thickness (axial direction thickness: S) extended along the center axis | shaft of the syringe mounting member 4a, as shown in FIG. The thickness of the flange 23 is preferably −1 to 1 mm, and in particular, the thickness of the flange 23 of the barrel 20 is preferably −0.5 to 0.5 mm.

  Further, in this embodiment, as shown in FIG. 44, there are two connecting portions 73a facing each other, and the connecting portions 73a are arranged in the radial direction of the syringe mounting member 4a as shown in FIG. A radial width W is provided. The radial width (W) is preferably 1 to 5 mm, and particularly preferably 2 to 3 mm.

  The syringe mounting member 4a of this embodiment includes a flange storage portion 44a formed (defined) by a distal end side support portion 71a, a proximal end side support portion 72a, and a connecting portion 73a. The flange housing portion 44a opens toward the side of the syringe mounting member 4a, and faces the flange insertion port 43a and the flange insertion port 43a for inserting the flange into the flange housing portion 44a. An opening 48a that opens toward the side of the mounting portion and into which a part of the flange stored in the flange storage portion can enter is provided.

  Further, as shown in FIGS. 39, 41, and 46, the flange housing portion 44a of the syringe mounting member 4a of this embodiment can be inserted with the flange 23 of the syringe 2 from one short diameter side (in other words, horizontally inserted). Possible slits. For this reason, in the state where the syringe 2 is mounted on the syringe mounting member 4a, one short-diameter portion of the flange 23 of the syringe 2 and the two long-diameter portions facing each other are housed in the barrel mounting portion 40a, The short diameter portion is exposed. Moreover, the edge part of one short diameter part of the flange accommodated in the syringe mounting member 4a is exposed from the opening part 48a. In this embodiment, the flange accommodating portion 44a is formed by a horizontally long U-shaped slit.

  Further, in this embodiment of the syringe mounting member 4a, as shown in FIGS. 39 to 48, the syringe mounting member 4a extends from the distal end of the distal end side support portion 71a to the proximal end of the proximal end side support portion 72a. It has the outer peripheral surface (outer wall part) extended along a central axis. Specifically, the outer peripheral surface (outer wall portion) has a semi-polygonal shape at the distal end side where the portion from the distal end of the distal end side support portion 71a to the flange insertion port 43a is missing, and the proximal end side from the flange insertion port 43a. It has a polygonal cylindrical shape.

  Further, in this embodiment of the syringe mounting member 4a, as shown in FIGS. 39 to 48, the syringe mounting member 4a extends from the barrel mounting portion 40a in the distal direction and supports the outer peripheral surface of the cylindrical portion of the barrel 20. A support portion 41a is provided. The barrel support portion 41a is formed by a substantially half-cylinder portion extending from the barrel mounting portion 40a (flange storage portion 44a) to the distal end side.

  Further, in the syringe mounting member 4a of this embodiment, as shown in FIGS. 39 to 48, the syringe mounting member 4a extends from the base end of the syringe mounting member 4a toward the base end of the gasket pressing tool 3a, and the gasket pressing member And a cylindrical insertion portion 47a extending from the proximal end of the cylindrical storage portion 42a toward the proximal end of the gasket pressing tool 3a and through which the shaft portion 51 of the plunger 5a is inserted. .

  The cylindrical storage portion 42a is a cylindrical portion that extends rearward from the proximal end of the syringe mounting member 4a. The cylindrical storage portion 42a includes a storage portion for the gasket pressing assembly therein. The cylindrical storage portion 42a extends in the proximal direction with an outer diameter smaller than the outer diameter of the proximal end support portion 72a of the syringe mounting member 4a.

  Furthermore, in the syringe mounting member 4a of this embodiment, as shown in FIGS. 42 to 44, the cylindrical storage portion 42a has a diameter that increases toward the distal end, and the proximal end of the proximal side support portion of the syringe mounting member 4a. It has the curved part 75a connected with. The curved portion 75a is formed in an annular shape. The curvature radius of the curved portion 75a is preferably 0.3 to 3 mm, and particularly preferably 0.5 to 1.5 mm.

  Furthermore, the syringe mounting member 4a of this embodiment includes a cylindrical insertion portion 47a that extends in the proximal direction of the gasket pressing tool 3a from the proximal end of the cylindrical storage portion 42a and into which the shaft portion 51 of the plunger 5a is inserted. . The shaft portion 51 of the plunger 5a includes a shaft side screwing portion 55, and an insertion portion side screwing portion 46a screwed with the shaft side screwing portion 55 is provided on the inner peripheral surface of the insertion portion 47a. In this embodiment, the shaft side screwing portion 55 is a helical groove, and the insertion portion side screwing portion 46a is a helical rib (specifically, a short helical rib) that is screwed with the helical groove portion. ).

  Further, as shown in FIG. 48, the insertion portion 47a includes an inner cylinder portion 77a including the insertion portion side screwing portion (short female screw) 46a and an outer side of the inner cylinder portion 77a (in other words, the inner cylinder portion 77). The outer cylinder 76a concentrically with the inner cylinder 77a, and the outer cylinder 76a and the outer cylinder 76a are connected to each other in the circumferential direction. A plurality of connecting plates 78a are disposed intermittently. It is preferable that 4-10 sheets of the plurality of connecting plates 78a are arranged at equal intervals in the circumferential direction of the syringe mounting member 4a.

  In this embodiment, the connecting plate 78a extends over the entire length of the inner cylindrical portion 77a. For this reason, the insertion part 47a which is a site | part screwed with the plunger 5a is firmly reinforced, and it is preventing that distortion arises in the syringe mounting member 4a in the said part. Further, the syringe mounting member 4a of this embodiment has a substantially uniform outer diameter from the distal end (curved portion 75a) of the cylindrical storage portion 42a to the proximal end of the outer cylindrical portion 76a of the insertion portion 47a. .

  The gasket pressing assembly 6a of this embodiment includes a gasket pressing member 8a, a sound generating member 9a, and a joint member 15, as shown in FIGS. As shown in FIGS. 39 and 49 to 51, the gasket pressing member 8 a enters the gasket 7, and is formed in the gasket entrance portion 80 that contacts the inner surface of the gasket, and in the rear portion of the gasket entry portion 80. A flange portion 81, an annular portion 82a extending rearward from the flange portion 81, and an annular rib 66 formed at the rear end portion of the annular portion 82a are provided. The annular rib 66 is provided with a notch 67. The in-gasket entry portion 80 includes a tip closing portion and a tapered reduced diameter portion extending from the flange portion 81 to the rear end of the tip closing portion.

  Also in the gasket pressing member 8a of this embodiment, as in the above-described embodiment, as shown in FIGS. 49 and 51, the sound generating member storage portion and the wall portions 88, 89 extending in the axial direction are provided inside. And a plunger abutting portion 62, a columnar recess 85, a cylindrical portion having a columnar recess 85 at the center, and four partition portions extending laterally from the cylindrical portion. The internal form of the gasket pressing member 8a is the same as the gasket pressing member 8 described above.

  As shown in FIGS. 49 and 50, the sound generating member 9a of this embodiment includes a cylindrical main body portion 90a, claw portions 92 and 93 protruding from the inner surface of the cylindrical main body portion 90a in the distal direction, and a cylindrical main body. A plurality of projecting portions 98 provided on the lower side surface of the portion 90a are provided. The form of the claw portions 92 and 93 is the same as that of the sound generating member 9 described above.

  In the gasket pressing member 8a of this embodiment, as described above, the internal configuration of the gasket pressing member 8a is the same as that of the gasket pressing member 8 described above, and the configuration of the sound generating member 9a is also the same as that of the above-described sound generating member 9. The sound generation mechanism in the gasket pressing member 8a of this embodiment is the same as described above.

  The gasket pressing assembly 6a of this embodiment includes a joint member 15 disposed at the rear portion of the gasket pressing member 8a. The gasket pressing member 8a accommodates the sound generating member 9a, and a joint member 15 is attached to the rear portion that opens. As shown in FIGS. 50 and 52, the joint member 15 includes a short cylindrical portion 18 having a disk-shaped bottom surface 18 a and a small-diameter cylindrical portion 17 extending rearward from the cylindrical portion 18. At the upper end of the cylindrical portion 18, a rib 19 protruding inward is provided. The joint member 15 is attached to the gasket pressing member 8a as shown in FIG. 49 by rotating the rib 19 after entering the notch 67 of the annular rib 66 formed at the rear end of the gasket pressing member 8a. It has been. The joint member 15 includes a plurality of inclined protrusions 65 extending from the inner surface of the small-diameter cylindrical portion 17 in the distal direction and in the center direction of the joint member. The plurality of inclined protrusions 65 are arranged at an equal angle with respect to the central axis of the joint member 15.

  As shown in FIGS. 53 and 54, the plunger 5 a in this embodiment has an annular rib 58 that is a tip portion and is formed on the rear end side of the claw flipping rib 54. The inner diameter at the minimum inner diameter formed by the plurality of inclined protrusions 65 of the joint member 15 is slightly larger than the outer diameter of the annular rib 58 of the plunger 5a. For this reason, the joint member 15 has a function of preventing the plunger 5a from coming off. In addition, the plunger 5a in this embodiment includes the structure of the tip portion similar to the plunger 5 described above, including the claw repelling rib 54, and the annular contact portion 56 of the plunger 5a connects the gasket pressing assembly 6a. In the state of being pressed so as to be able to be pressed, the claw flipping rib 54 is located on the side of the toe portions 92a and 93a. The plunger 5a is advanced by the rotation of the plunger 5a to advance the gasket pressing assembly 6a, and the claw flipping ribs 54 are brought into contact with the toe portions 92a and 93a to deform and pass the claw portions 92 and 93. At the same time, sound is generated by the contact of the claws 92 and 93 with the walls 88 and 89 restored after the passage.

  In all the embodiments described above, the gasket pressing member may be of the type provided in the drug solution administration tool 1b and the syringe gasket pressing tool 3b of the embodiment shown in FIG. The gasket pressing member 8b in this embodiment has substantially no part that enters the gasket 7a. For this reason, the gasket pressing assembly 6b substantially does not have a portion that enters the gasket 7a. The gasket pressing member 8b is provided with a pressing portion 81b which is in contact with the rear end surface of the gasket 7a and can be pressed at the front end. The drug solution administration tool 1b and the syringe gasket pressing tool 3b of this embodiment also have the same sound generating mechanism as the drug solution administration tools 1 and 1a and the syringe gasket pressing tools 3 and 3a described above.

  Next, as an example of a treatment method using the drug administration device 1 of the present invention, endoscopic submucosal dissection (ESD) or endoscopic mucosal resection (EMR) is performed. The case where it performs is demonstrated. First, the endoscopic submucosal dissection will be described. This procedure is usually performed by two people.

The first operator injects a sodium hyaluronate solution, and the second operator performs excision of the affected part for confirmation of the endoscopic image.
The first surgeon prepares the drug administration device 1 in which the syringe gasket pressing tool 3 is attached to the prefilled syringe 2 filled with the sodium hyaluronate solution 11. When the prepared drug administration device 1 is in the state shown in FIGS. 1 and 2, the plunger 5 is rotated to attach the gasket pressing assembly 6 in the gasket 7 as shown in FIG. 7. Then, the seal cap 21 is removed from the prefilled syringe 2.

  Next, the first operator connects the distal end portion of the syringe 2 to the proximal end portion of the inner catheter 112 of the puncture device 110 and causes the needle 112a to protrude from the outer catheter 114 as shown in FIG. In this state, the plunger 5 is rotated to perform priming to fill the inner catheter 112 and the lumen of the needle 112a with the sodium hyaluronate solution 11. The inner catheter 112 in the puncture device 110 is slidable in the axial direction within a range restricted with respect to the outer catheter 114. A needle 112 a is connected to the distal end of the inner catheter 112. When the inner catheter 112 is in a retracted position relative to the outer catheter 114, the needle 112a is housed within the outer catheter 114. The needle 112a protrudes from the distal end of the outer catheter 114 when the inner catheter 112 is in an advanced position relative to the outer catheter 144a.

  Next, the second operator stores the needle 112 a in the outer catheter 114. Then, the puncture device 110 is inserted into the insertion hole 116a (see FIG. 57) of the endoscope 116. Subsequently, as shown in FIG. 57, the second operator causes the needle 112a to protrude from the distal end of the endoscope 116 in the digestive tract of the patient. Then, it penetrates the mucous membrane 120 around the lesioned part 128 and reaches the submucosal layer 121. The second operator tells the first operator that the needle has reached the mucosal layer 121.

  The second surgeon tells the first surgeon the number of click sounds for injection. The first surgeon rotates the plunger 5 by the number of click sounds transmitted to inject the sodium hyaluronate solution 11 into the submucosa 121. The second operator confirms by hearing that a predetermined amount of sodium hyaluronate solution 11 has been injected by confirming the number of click sounds. The second surgeon confirms the endoscopic image and, if necessary, informs the first surgeon the number of click sounds for the best injection. The first surgeon rotates the plunger 5 by the number of click sounds transmitted to inject the sodium hyaluronate solution 11 into the submucosa 121. When this operation is performed as many times as necessary and the lesioned part 128 is raised to a target size, the state shown in FIG. 58 is obtained. In this state, the submucosal layer 121 under the lesioned part 128 is peeled from the muscle layer 122.

The second operator tells the first operator the end of the injection operation of the sodium hyaluronate solution. The first surgeon who heard it releases the pressure by rotating the plunger 5 in the reverse direction. Thereby, discharge of the sodium hyaluronate solution 11 from the syringe 2 stops.
Next, as shown in FIG. 59, the second operator inserts a peeling device 134 (needle scalpel or the like) into the forceps hole 116a of the endoscope 116 and surrounds the lesioned portion 128 using the peeling device 134. Cut the mucous membrane 120. Subsequently, as shown in FIG. 60, the second operator inserts the grasping device 136 into the forceps hole 116 a of the endoscope 116, and peels off the mucous membrane 120 having the lesioned portion 128 using the grasping device 136. Then, the peeled mucous membrane 120 is taken out of the body.

  On the other hand, when endoscopic mucosal resection is performed, an ablation device 138 indicated by a virtual line in FIG. 59 is used instead of the above-described exfoliation of the mucous membrane 120 by the exfoliation device 134. The ablation device 138 has a snare ring 138a (looped electric knife). The second operator causes the snare ring 138a to protrude from the endoscope 116 in the body of the patient, and hooks the snare ring 138a on the mucous membrane 120 around the raised lesioned part 128. Then, the snare ring 138a is squeezed, a high-frequency current is passed through the snare ring 138a, and the mucous membrane 120 having the lesioned part 128 is cut. The cut mucous membrane 120 is collected by the grasping device 136 shown in FIG. The other procedure steps are performed in the same manner as the endoscopic submucosal dissection described above.

DESCRIPTION OF SYMBOLS 1 Chemical solution administration tool 2 Prefilled syringe 3 Syringe gasket pressing tool 4 Syringe mounting member 5 Plunger 6 Gasket pressing assembly 8 Gasket pressing member 9 Sound generating member 20 Barrel 23 Flange

Claims (12)

A gasket pressing tool used by being attached to a syringe having a barrel having an annular flange at a proximal end, and a gasket that is slidable in the barrel and made of an elastic material,
The gasket pressing tool includes a gasket pressing member for pressing the gasket, a cylindrical syringe mounting member that movably houses the gasket pressing member and can be mounted on the base end of the barrel, and the syringe. A distal end portion enters the mounting member, and includes a plunger capable of pressing the gasket pressing member in the distal direction.
The plunger is provided at a distal end portion capable of pressing the gasket pressing member, a shaft portion extending in a proximal direction from the distal end portion and having a shaft-side threaded portion on an outer peripheral surface, and a proximal end portion of the shaft portion. A handle for rotating the plunger,
The syringe mounting member includes a barrel mounting portion that can store the flange of the barrel, and a cylindrical storage that can extend from the base end of the barrel mounting portion toward the base end of the gasket pressing tool and store the gasket pressing member. A cylindrical insertion portion that extends from the proximal end of the cylindrical storage portion in the proximal direction of the gasket pressing tool and through which the shaft portion of the plunger is inserted,
The insertion portion of the syringe mounting member has an insertion portion side screwing portion that is screwed with the shaft side screwing portion of the shaft portion on an inner peripheral surface,
The barrel mounting portion includes a distal end side support portion capable of supporting the distal end surface of the flange, a proximal end side support portion capable of supporting the proximal end surface of the flange, the distal end side support portion and the proximal end side support portion. Are formed by a connecting portion that connects the front end side support portion, the base end side support portion, and the connecting portion, and opens toward a side of the barrel mounting portion. And a flange insertion port for inserting the flange into the flange housing portion,
The distal side support part has an axial thickness of 5 to 25 mm along the central axis of the syringe mounting member, and the proximal side support part is 5 to 25 mm along the central axis of the syringe mounting member. The gasket pressing tool according to claim 1, wherein the connecting portion has a radial width of 1 to 5 mm along a radial direction of the syringe mounting member. The gasket pressing tool according to claim 1, wherein the barrel mounting portion has an outer peripheral surface extending along the central axis of the syringe mounting member from a distal end of the distal end side support portion to a proximal end of the proximal end side support portion. . The gasket pressing tool according to claim 1 or 2, wherein the tip side support portion can support 55 to 80% of the tip surface of the flange. The barrel mounting portion has an opening that faces the flange insertion port with respect to the central axis of the syringe mounting member and into which a part of the flange stored in the flange storage portion can enter. The gasket pressing tool according to any one of 1 to 3. The insertion part of the syringe mounting member includes an inner cylinder part having the insertion part side screwing part on an inner peripheral surface, and an outer cylinder part arranged concentrically outside the inner cylinder part and with the inner cylinder part. The gasket according to any one of claims 1 to 4, further comprising a plurality of connecting plates intermittently arranged in the circumferential direction, wherein the outer peripheral surface of the inner cylindrical portion and the inner peripheral surface of the outer cylindrical portion are connected. Pressing tool. The gasket pressing tool according to claim 5, wherein 4 to 10 of the plurality of connecting plates are arranged at equal intervals in the circumferential direction of the syringe mounting member. The gasket pressing tool according to claim 6, wherein the syringe mounting member has a substantially uniform outer diameter from a distal end of the cylindrical storage portion to a proximal end of the outer cylindrical portion of the insertion portion. The gasket pressing tool according to any one of claims 1 to 7, wherein the cylindrical storage portion has an outer diameter smaller than an outer diameter of the base end side support portion of the barrel mounting portion. The gasket pressing tool according to claim 8, wherein the cylindrical storage portion has a curved portion that expands toward a distal end and is connected to a proximal end of the proximal end side support portion of the barrel mounting portion. The gasket pressing tool according to claim 9, wherein the curved portion has a radius of curvature of 0.3 to 3. 11. The gasket pressing tool according to claim 1, wherein the syringe mounting member includes a barrel support portion that extends in a distal direction from the flange housing portion and supports an outer peripheral surface of the cylindrical portion of the barrel. It consists of the gasket pressing tool in any one of Claims 1 thru | or 11, the said syringe, the chemical | medical solution with which the said syringe was filled, and the sealing member which seals the front-end | tip part of the said barrel. Drug administration device.

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