JP2019170734A - Absorbent article - Google Patents

Abstract

To provide an absorbent article capable of masking odor generated from excrement and suppressing skin troubles.SOLUTION: An absorbent article comprises a liquid holding absorbent core. A flavoring agent having lipase activity inhibitory effect and fungus active inhibitory effect is applied to any member positioned on a skin-facing surface in the absorbent core or on a side near the body of a wearer than the skin-facing surface. The member with the flavoring agent is preferably at least one of a liquid permeable top sheet and a core wrap sheet covering at least skin-facing surface side of the absorbent core. The flavoring agent preferably enhances volatility under the presence of moisture. The flavoring agent preferably contains at least one kind selected from rose ketones, γ-lactone with a carbon number of 10 or more and 12 or less, and δ-lactone with a carbon number of 9 or more and 12 or less. The absorbent article is preferably a sanitary napkin.SELECTED DRAWING: None

Description

  The present invention relates to an absorbent article.

  Absorbent articles such as disposable diapers and sanitary napkins may rash on the skin during their wearing. Such skin troubles include irritation such as stuffiness caused by moisture contained in excrement (urine, loose stool, menstrual blood, sweat, etc.), rubbing between the skin and components of the absorbent article, skin resident bacteria It is known to be caused by stimulation by enzymes secreted by In order to suppress such skin troubles, Patent Document 1 uses an anti-rash agent derived from a plant extract having an antibacterial action against bacteria and an inhibitory action against enzymes involved in the occurrence of skin troubles in absorbent articles. Is described.

Japanese Patent Laid-Open No. 2005-2008

  However, since the anti-rash agent described in Patent Document 1 is derived from a plant extract, depending on the extraction conditions and the impregnation method of the absorbent article, the anti-rash effect cannot be sufficiently exhibited. It was. Further, when an absorbent article is impregnated with the anti-rash agent described in Patent Document 1, the base material constituting the absorbent article is colored by the color or scent of the plant extract and the appearance of the article is impaired. Or the smell derived from excrement may be perceived in the wearing state of the absorbent article.

  Therefore, the subject of this invention is providing the absorbent article which solves the fault of a prior art.

  The present invention comprises a liquid-retaining absorbent core, and has a lipase activity inhibitory effect on the skin facing surface of the absorbent core or any member located closer to the wearer's body than the skin facing surface, and The present invention provides an absorbent article to which a fragrance having a fungus activity inhibitory effect is applied.

  ADVANTAGE OF THE INVENTION According to this invention, the absorbent article which can mask the smell which arises from excretion and can suppress skin trouble can be provided.

FIG. 1 (a) thru | or (c) are graphs which show the moisture content change of the skin surface, pH change, and lipase activity change in the presence or absence of wearing of an absorbent article. FIGS. 2A and 2B are graphs showing the lipase activity inhibitory effect and the fungal activity inhibitory effect in the presence of sebum. FIG. 3 is a graph showing the lipase activity inhibitory effect of jasmolactone.

  Hereinafter, the present invention will be described based on preferred embodiments thereof. The absorbent article of the present invention generally has a vertically long shape having a longitudinal direction corresponding to a direction extending from the wearer's stomach side to the back side through the crotch part and a width direction perpendicular thereto. And an absorbent article has a crotch part distribute | arranged to a wearer's crotch part, and the abdominal side part and back side part which are extended before and behind that. The crotch portion has an excretion portion facing portion that is disposed to face the excretion portion of the wearer when the absorbent article is worn, and the excretion portion facing portion is usually the central portion in the longitudinal direction of the absorbent article or the vicinity thereof Is located.

  Absorbent articles generally include a top sheet positioned on the skin facing surface side of the wearer, a back sheet positioned on the non-skin facing surface side, and an absorbent body disposed between both sheets. As the surface sheet, a liquid-permeable sheet such as a nonwoven fabric or a perforated film can be used. As for a surface sheet, the skin opposing surface side may be uneven | corrugated shape. For example, a plurality of convex portions can be formed in the form of dots on the skin facing surface side of the topsheet. Or the collar part and groove part which extend in one direction can be alternately formed in the skin opposing surface side of a surface sheet. For such a purpose, a surface sheet can also be formed using two or more nonwoven fabrics.

  On the other hand, as the back sheet, for example, a liquid-impermeable film, a spunbond / meltblown / spunbond laminated nonwoven fabric, or the like can be used. A plurality of micropores may be provided in a liquid-impermeable film to impart water vapor permeability to the film. For the purpose of further improving the touch of the absorbent article, a sheet having a good texture such as a nonwoven fabric may be laminated on the outer surface of the back sheet.

  The absorber has a liquid-retaining absorbent core. The absorbent core is, for example, a pile of hydrophilic fibers such as cellulose including pulp, a mixed pile of hydrophilic fibers and an absorbent polymer, an absorbent polymer deposit, and a space between two absorbent sheets. And a laminated structure in which an absorbent polymer is supported. The absorbent core may have at least the skin facing surface covered with a liquid permeable core wrap sheet, and the entire surface including the skin facing surface and the non-skin facing surface may be covered with the core wrap sheet. . As the core wrap sheet, for example, a thin paper made of hydrophilic fibers, a liquid-permeable nonwoven fabric, or the like can be used.

  In addition to the above-mentioned top sheet, back sheet and absorbent body, a leak-proof cuff extending along the longitudinal direction is arranged on both sides along the longitudinal direction on the skin facing surface side according to the specific application of the absorbent article. There is a case. Leak-proof cuffs generally have a proximal end and a free end. The leak-proof cuff has a proximal end portion on the skin facing surface side of the absorbent article, and stands up from the skin facing surface side. The leak-proof cuff is made of a liquid-resistant or water-repellent and breathable material. An elastic member made of rubber thread or the like may be disposed in an extended state at or near the free end of the leak-proof cuff. When the elastic member contracts in the wearing state of the absorbent article, the leak-proof cuff comes to stand up toward the wearer's body, and the liquid excreted on the top sheet is transferred to the top sheet and absorbs Leaking outward in the width direction of the article is effectively prevented.

  The absorbent article may further have an adhesive layer on the surface of the non-skin facing surface. The pressure-sensitive adhesive layer is used for fixing the absorbent article to underwear or another absorbent article when the absorbent article is worn.

  The absorbent article of the present invention contains a fragrance. The fragrance is not particularly limited as long as the fragrance component is volatilized in the atmosphere at atmospheric pressure, and it is preferable that the fragrance can be perceived in an environment of normal temperature and pressure. By using such a fragrance, an unpleasant odor caused by excrement such as urine and menstrual blood can be masked by the fragrance of the fragrance.

  By the way, when wearing an absorptive article for a long period of time, skin troubles, such as a rash, may arise due to the constituent member of the absorptive article being in direct contact with the wearer's skin. It is known that such skin troubles are caused by irritation such as stuffiness caused by moisture of excrement, rubbing between the skin and components of absorbent articles, irritation by components produced by enzymes of skin resident bacteria, etc. It has been.

  The following mechanisms are considered as the occurrence mechanism of skin troubles. The barrier function on the skin surface is reduced by steaming or rubbing, and the substance permeability of the skin is increased. When excrement such as urine and menstrual blood adheres to the skin with enhanced substance permeability, normal bacteria such as Malassezia bacteria grow and moisture on the skin increases the pH of the skin surface. To rise. Enzyme activity such as lipolytic enzyme (lipase) produced by skin resident bacteria increases with the growth of resident bacteria and the increase in skin pH. As the enzyme activity increases, sebum is decomposed and fatty acids are released. This free fatty acid stimulates the skin with enhanced substance permeability and causes inflammation. As a result, skin troubles such as rash occur.

  As described above, absorbent articles are required to take measures against unpleasant odors caused by excrement and prevent skin troubles. For these countermeasures, it is conceivable that the above-described fragrance is contained in an absorbent article, or a drug capable of suppressing skin trouble is contained in the absorbent article. However, it is not advantageous from the industrial and economic viewpoints to separately add a fragrance or a drug to the absorbent article. Therefore, the inventors have intensively studied, and by incorporating a fragrance having a lipase activity inhibitory effect and a fungal activity inhibitory effect into the absorbent article, the odor derived from excrement due to the fragrance aroma is a general purpose of the fragrance. In addition to the masking effect, it has been found that the activity inhibiting effect of bacteria causing skin troubles such as skin irritation and the enzyme activity inhibiting effect such as lipase are exhibited. It has also been found that these effects can be sufficiently achieved without using other agents such as antibacterial agents and anti-inflammatory agents if the fragrance used in the present invention is used.

  The lipase activity inhibitory effect in the present invention is to have at least an effect of inhibiting the activity of a lipolytic enzyme (lipase) produced by Malassezia sp. In addition, the fungal activity inhibitory effect is to have at least an effect of suppressing the growth of Malassezia spp. Examples of the genus Malassezia include, but are not limited to, Malassezia furfur, Malassezia globosa, Malassezia restricta, Malassezia sympodialis, and the like. The lipase activity inhibitory effect and the fungus activity inhibitory effect can be measured, for example, according to the method of JP2013-249293A. When the lipase activity inhibition rate measured according to the method described in the document is 50% or more and the growth inhibition rate is 50% or more, it is judged that the lipase activity inhibition activity and the fungus inhibition activity effect are obtained.

  The following mechanism is considered as a mechanism that can suppress unpleasant odor masking caused by excrement and skin troubles by the fragrance used in the present invention. The fragrance | flavor currently given to the absorbent article of this invention volatilizes, a fragrance component is perceived by the user, and the component of this fragrance | flavor adheres directly to the skin surface of the wearing site vicinity of an absorbent article. Since the fragrance has a lipase activity inhibitory effect and a fungus activity inhibitory effect, it suppresses the lipase activity produced by the skin resident bacteria present on the skin surface, suppresses the production of free fatty acids, and proliferates the fungus itself. Suppress. As a result, it is possible to mask unpleasant odor caused by excrement and suppress skin troubles.

  In particular, the absorbent article is intended to absorb and retain watery excrement such as urine and menstrual blood. From the viewpoint of achieving both masking and suppression of skin trouble, the fragrance used in the present invention has increased volatility in the presence of moisture, provided that the components are volatilized in the atmosphere at atmospheric pressure. It is preferable that “Increased volatility in the presence of moisture” means that the fragrance component to be evaluated is dropped on the cut absorbent article and then injected with suspicious blood as a sample in the presence of moisture, and the cut absorbency Measured in the absence of moisture (during drying) when the fragrances of these samples were measured as the “in the absence of moisture (during drying)” sample with the perfume component to be evaluated dropped on the article. This means that the fragrance component remaining in the sample is lower than when it is applied.

  From the above viewpoint, examples of the fragrance that can be used in the present invention include rose ketones, γ-lactone having 10 to 12 carbon atoms, and δ-lactone having 9 to 12 carbon atoms. Examples of rose ketones include damasenone, α-damascon, β-damascon, γ-damascon, δ-damascon, isodamascon, α-ionone, β-ionone, α-allylionone, dihydro-β-ionone, dynascon, etc. It is done. Examples of γ-lactone having 10 to 12 carbon atoms include γ-decanolactone, γ-undecanolactone, and γ-dodecanolactone. Examples of the δ-lactone having 9 to 12 carbon atoms include δ-nonalactone, δ-decanolactone, δ-undecanolactone, 6- (3-pentenyl) tetrahydro [2H] pyran-2-one (hereinafter, jasmolactone). Or the like)). These can be used alone or in combination of two or more.

  From the viewpoint of achieving both the masking of the smell of excrement and the suppression of skin trouble, it is preferable to use at least a δ-lactone having 10 to 12 carbon atoms as a fragrance contained in the absorbent article of the present invention. In particular, from the viewpoint of masking the odor of excrement and further exerting an effect of suppressing skin trouble, δ-lactone having 10 to 12 carbon atoms is 6- (3-pentenyl) tetrahydro [2H] pyran-2- More preferably, it is on (jasmolactone).

  In the absorbent article of the present invention, from the viewpoint of effectively suppressing skin trouble by directly attaching the fragrance volatilized from the absorbent article to the skin, is the fragrance applied to the skin facing surface in the absorbent core, Or a core wrap that covers at least the skin-facing surface side of the liquid-permeable surface sheet and the absorbent core, preferably provided on any member located closer to the wearer's body than the skin-facing surface More preferably, it is applied to at least one of the sheets. It is also preferable that the sub-layer sheet disposed between the top sheet and the absorber is applied. It is also preferable that it is applied to the skin contact surface in the leak-proof cuff. The fragrance | flavor may be given only to the opposing area | region of the excretion part, and in addition to the opposing area | region of an excretion part, it may be further given to the abdominal part and / or the back part. Moreover, the application pattern of the fragrance may be applied to the entire surface of the member to be applied (so-called solid coating), may be applied in a streak shape, or may be applied in a dotted pattern. As a method for applying the fragrance, it can be appropriately selected depending on the type of the fragrance to be used. For example, after the fragrance is dispersed in a solvent such as water or ethanol, coating using a roll coater or a brush, spraying or the like is used. It can be applied by spraying or dipping.

The content of the fragrance used in the present invention is expressed as the basis weight per unit area of the fragrance in the absorbent body from the viewpoint of achieving both masking of the smell of excrement and suppressing skin troubles, and is 0.0015 mg / cm ^2. preferably or more, more preferably 0.04 mg / cm ² or more, further preferably 0.06 mg / cm ² or more, and is preferably at 2 mg / cm ² or less, 1 mg / more preferably cm ² or less, further preferably 0.5 mg / cm ² or less.

  As long as the effect of the present invention is not impaired, the absorbent article of the present invention may contain components other than the fragrance described above. Examples of other components include dyes, color pigments, antibacterial agents, anti-inflammatory agents, moisturizers, pH adjusters, water-proofing agents, etc., and one of these may be used alone or in combination of two or more. Can be used.

  Moreover, in addition to the fragrance | flavor which concerns on this invention, the other fragrance | flavor which has a rose fragrance | flavor tone, a lavender fragrance tone, a jasmine fragrance tone, and a ylang-ylang fragrance tone may be included for the purpose of the masking of the odor which arises from excrement. Examples of fragrance components in other fragrances include nerol, lavandulol, jasmar, cyclopiden, and the like, and one of these can be used alone or in combination of two or more. Moreover, the thing (fragrance | flavor composition) which was combined with the fragrance | flavor raw material comprised by several fragrance | flavors like natural essential oil and a preparation base, and was diluted with the solvent is also contained in another fragrance | flavor.

  As described above, according to the present invention, it is possible to provide an absorbent article capable of masking odor generated from excrement and capable of suppressing skin trouble. The absorbent article of the present invention broadly includes articles used to absorb excretions (urine, loose stool, menstrual blood, sweat, etc.) discharged from the human body, and includes sanitary napkins, disposable diapers, incontinence pads, panties. Liners and the like are also included. The absorbent article of the present invention is particularly effective when used as a sanitary napkin because skin troubles can be effectively suppressed even when excrement is in direct contact with the skin for a long time.

  As mentioned above, although this invention was demonstrated based on the preferable embodiment, this invention is not restrict | limited to the said embodiment. For example, although the fragrance | flavor of this invention has a lipase activity inhibitory effect, in addition to this effect, you may have the effect of inhibiting other enzyme activities, such as protease and urease.

  Hereinafter, the present invention will be described in more detail with reference to examples. However, the scope of the present invention is not limited to such examples.

[Test Example 1: Measurement of moisture content change, pH change and lipase activity change on the skin surface]
Prior to evaluation in the examples, changes in moisture content, changes in pH, and changes in lipase activity when the sanitary napkin was worn were measured. Specifically, suspicious blood is applied to cotton shorts cut to 6 cm square (this is sample A) or sanitary napkins cut to 6 cm square (Laurie (registered trademark) Slim Guard, manufactured by Kao Corporation). 6 g absorbed (this is referred to as sample B) was used. These samples were not given the fragrance used in the present invention. Each of these samples was attached to the inner side of the human forearm for 3 hours, and the moisture content change, pH change, and lipase activity change on the skin surface at the attachment site were measured as follows. These measurements were performed five times, and the measured values are shown in FIGS. 1A to 1C as an average value ± standard error. In the t-test, p <0.05 was considered significant.

<Measurement of moisture content on skin surface>
The amount of moisture on the skin surface is determined by using a moisture checker (MY-707S, manufactured by SCARA) and the amount of moisture on the surface of the skin immediately after removing the sample attached to the inner side of the human forearm. Was continuously measured 5 times. The moisture content on the skin surface of the unmounted part was taken as a reference point (zero point), and the change in the moisture content on the skin surface is shown in FIG.

<Measurement of skin surface pH change>
To change the pH of the skin surface, use a pH meter D51 (Horiba, Probe 6261), drop 1 drop of purified water on the inner side of the human forearm to adjust to the skin, and then measure the pH of that part 5 times continuously. did. The change in pH of the skin surface is shown in FIG. 1 (b), with the pH of the skin surface at the non-wearing site as a reference (zero point).

<Measurement of changes in lipase activity on the skin surface>
The change in lipase activity on the skin surface was observed after 3 hours of wearing on the human forearm skin surface, and then the skin surface stratum corneum was collected with tape, and the tape was extracted with 0.1% Triton X-100 solvent for 2 hours. Centrifuged at 1000 rpm for 5 minutes. The supernatant was used as a lipase solution and measured according to the method described in JP2013-249293A. Specifically, the production amount of 4-methylumbelliferone was measured as a fluorescence intensity (excitation light: 360 nm) at 460 nm using a 1420 Multilabel Counter (manufactured by Wallac). The results are shown in FIG.

  As shown in FIGS. 1 (a) to 1 (c), in the group in which suspicious blood was absorbed by the sanitary napkin, the amount of water on the skin surface increased and the pH on the skin surface was higher than in the group only with shorts. Highly changed, lipase activity increased.

[Test Example 2: Measurement of lipase activity inhibitory effect and fungal activity inhibitory effect in the presence of sebum]
The lipase activity inhibitory effect and fungal activity inhibitory effect in the presence of sebum were measured as follows. That is, after wearing Sample B of Test Example 1 on the human forearm skin surface for 3 hours, the stratum corneum on the skin surface was collected with a tape. This tape was immersed in 0.1% Triton X-100 for 2 hours, subjected to ultrasonic crushing, and then centrifuged at 1000 rpm for 5 minutes. The supernatant is made into a lipase-containing solution, and each fragrance and substrate (4-methylumbelliferone oleate) shown in FIGS. 2 (a) and (b) are added to this supernatant, and in the absence of sebum or in a predetermined amount The reaction was carried out in the presence of sebum at 37 ° C. and 250 rpm for 2 hours. After the reaction, the production amount of 4-methylumbelliferone was measured in the same manner as in Test Example 1. Moreover, the fungus activity inhibitory effect was measured according to the method described in JP2013-249293A. A numerical value lower than that of the control indicates inhibitory activity. The results are shown in FIGS. 2 (a) and (b).

  As shown in FIGS. 2 (a) and (b), in particular, in the presence of rose ketones, γ-lactone having 10 to 12 carbon atoms, and fragrance 9 to 12 carbon atoms δ-lactone, It can be seen that a lipase activity inhibitory effect and a fungal activity inhibitory effect are exhibited.

[Test Example 3: Measurement of volatility of jasmolactone]
In this test example, the volatility of jasmolactone, a fragrance for which the lipase activity inhibitory effect and the fungal activity inhibitory effect were confirmed in Test Example 2, was measured. A sample in which 3 μL (60 μg as jasmolactone) of jasmolactone 2% by mass ethanol solution was dropped on the surface sheet side of a sanitary napkin (Laurie (registered trademark) Slimguard, manufactured by Kao Corporation) cut into 2 cm square was used. . The back sheet was a non-moisture permeable sheet or a moisture permeable sheet. These samples were allowed to stand for 20 minutes in a chamber set at 35 ° C. and 65% RH. Thereafter, each sample was immersed in 10 mL of ethanol, and the remaining jasmolactone was extracted to obtain a measurement sample. In addition, as a control sample, 3 μL of a 2% by weight ethanol solution of jasmolactone was dropped on a sanitary napkin cut into a 2 cm square and immediately immersed in 10 mL of ethanol to extract the remaining jasmolactone. It was. For these samples, the residual amount of jasmolactone was detected under the following measurement conditions using a gas chromatograph, and the residual rate (%) was calculated. The results are shown in Table 1.

<Device>
Gas chromatograph (6890N, manufactured by Agilent).
<Column>
DB-1701 (Agilent J & W) length 30m x inner diameter 0.25mm, film thickness: 1μm)
<Measurement conditions>
Column temperature: raised from 100 ° C. to 240 ° C. at 10 ° C./min and maintained at 240 ° C. for 6 minutes Carrier gas: helium Linear velocity: 335 cm / sec
Pressure mode: Constant pressure Inlet temperature: 200 ° C
Injection method: Splitless Injection volume: 1 μL
Detector: FID
Detector temperature: 260 ° C

  As shown in Table 1, it can be seen that jasmolactone is volatilized by about 60%. Further, even when the back sheet was a non-moisture permeable sheet or a moisture permeable sheet, no difference in volatility of jasmolactone was observed. As this reason, since jasmolactone is dripped at the surface sheet, it is considered that jasmolactone is preferentially volatilized from the surface sheet side.

[Example 1: Measurement of lipase activity inhibitory effect of jasmolactone]
In this example, the lipase inhibitory activity on the skin surface with or without jasmolactone was measured using jasmolactone, a fragrance for which the lipase activity inhibitory effect and the fungal activity inhibitory effect were confirmed in Test Example 2. As samples, 3 μL each of Jasmolactone 2% by mass ethanol solution on the surface sheet side of Sample B in Test Example 1 and a sanitary napkin (Laurie (registered trademark) Slimguard, Kao Corporation) cut to 6 cm square After dripping in 3 places, what absorbed 6g of suspicious blood (this is made into sample C) was used. Samples B and C were attached to the skin surface of the human forearm, and the lipase activity inhibitory effect was measured by the method described above. As a comparative control, the result of lipase activity on the surface of the human forearm skin that was not worn was used. The results are shown in FIG.

As shown in FIG. 3, it can be seen that lipase activity can be remarkably inhibited by applying jasmolactone having a lipase activity inhibitory effect and a fungal activity inhibitory effect to the absorbent article.

Claims (6)

  Provided with a liquid-retaining absorbent core, on the skin facing surface of the absorbent core, or on any member located closer to the wearer's body than the skin facing surface, lipase activity inhibitory effect and fungal activity Absorbent article with a perfume having an inhibitory effect.   The absorbent article according to claim 1, wherein the member is at least one of a liquid-permeable surface sheet and a core wrap sheet that covers at least the skin facing surface side of the absorbent core.   The absorptive article according to claim 1 or 2 in which said fragrance increases volatility in the presence of moisture.   The absorptive article according to claim 3 in which said fragrance | flavor contains at least 1 sort (s) among rose ketones, (gamma) -lactone of C10-C12, and delta-lactone of C9-C12.   The absorbent article according to claim 4, wherein the δ-lactone is 6- (3-pentenyl) tetrahydro [2H] pyran-2-one. The absorbent article as described in any one of Claims 1 thru | or 5 which is a sanitary napkin.