JP2019167359A5 - - Google Patents
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- JP2019167359A5 JP2019167359A5 JP2019095746A JP2019095746A JP2019167359A5 JP 2019167359 A5 JP2019167359 A5 JP 2019167359A5 JP 2019095746 A JP2019095746 A JP 2019095746A JP 2019095746 A JP2019095746 A JP 2019095746A JP 2019167359 A5 JP2019167359 A5 JP 2019167359A5
- Authority
- JP
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- Prior art keywords
- independently
- heterocycloalkyl
- alkyl
- heterocycle
- heteroalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000000623 heterocyclic group Chemical group 0.000 claims 26
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims 25
- 125000000217 alkyl group Chemical group 0.000 claims 24
- 150000003839 salts Chemical class 0.000 claims 22
- 239000011780 sodium chloride Substances 0.000 claims 22
- 239000012453 solvate Substances 0.000 claims 19
- 125000003118 aryl group Chemical group 0.000 claims 17
- 230000027455 binding Effects 0.000 claims 17
- 210000004027 cells Anatomy 0.000 claims 17
- 125000004404 heteroalkyl group Chemical group 0.000 claims 17
- 125000004448 alkyl carbonyl group Chemical group 0.000 claims 14
- 102000004965 antibodies Human genes 0.000 claims 11
- 108090001123 antibodies Proteins 0.000 claims 11
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 11
- -1 alkyl amides Chemical class 0.000 claims 10
- 125000005119 alkyl cycloalkyl group Chemical group 0.000 claims 10
- 125000003342 alkenyl group Chemical group 0.000 claims 9
- 108020005497 Nuclear hormone receptors Proteins 0.000 claims 7
- 150000001413 amino acids Chemical group 0.000 claims 7
- 231100000599 cytotoxic agent Toxicity 0.000 claims 7
- 239000002619 cytotoxin Substances 0.000 claims 7
- 229910052739 hydrogen Inorganic materials 0.000 claims 7
- 229910052760 oxygen Inorganic materials 0.000 claims 7
- 229910052717 sulfur Inorganic materials 0.000 claims 7
- 125000000304 alkynyl group Chemical group 0.000 claims 6
- 229910052799 carbon Inorganic materials 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 6
- 101700027111 3SA0 Proteins 0.000 claims 5
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 5
- 101700067609 ctx Proteins 0.000 claims 5
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- 125000001072 heteroaryl group Chemical group 0.000 claims 5
- 125000005647 linker group Chemical group 0.000 claims 5
- 125000004432 carbon atoms Chemical group C* 0.000 claims 4
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 3
- 239000000427 antigen Substances 0.000 claims 3
- 108091007172 antigens Proteins 0.000 claims 3
- 102000038129 antigens Human genes 0.000 claims 3
- 125000003710 aryl alkyl group Chemical group 0.000 claims 3
- 125000002837 carbocyclic group Chemical group 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 102000005614 monoclonal antibodies Human genes 0.000 claims 3
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- 101700032463 nhr-14 Proteins 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
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- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 2
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- 101710037934 QRSL1 Proteins 0.000 claims 2
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- 101710030971 TNFRSF10A Proteins 0.000 claims 2
- 201000009596 autoimmune hypersensitivity disease Diseases 0.000 claims 2
- 201000011510 cancer Diseases 0.000 claims 2
- 125000004181 carboxyalkyl group Chemical group 0.000 claims 2
- 108091006028 chimera Proteins 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000006448 cycloalkyl cycloalkyl group Chemical group 0.000 claims 2
- 201000009910 diseases by infectious agent Diseases 0.000 claims 2
- 125000005343 heterocyclic alkyl group Chemical group 0.000 claims 2
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 101700064993 nhr-18 Proteins 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 102000005962 receptors Human genes 0.000 claims 2
- 108020003175 receptors Proteins 0.000 claims 2
- PQEJXGNZBLONLG-XJDOXCRVSA-N (2R)-2-amino-3-[1-[3-[2-[4-[1,3-bis(2-methoxyethylcarbamoyloxy)propan-2-yloxy]butanoylamino]ethylamino]-3-oxopropyl]-2,5-dioxopyrrolidin-3-yl]sulfanylpropanoic acid Chemical compound COCCNC(=O)OCC(COC(=O)NCCOC)OCCCC(=O)NCCNC(=O)CCN1C(=O)CC(SC[C@H](N)C(O)=O)C1=O PQEJXGNZBLONLG-XJDOXCRVSA-N 0.000 claims 1
- FFILOTSTFMXQJC-QCFYAKGBSA-N (2R,4R,5S,6S)-2-[3-[(2S,3S,4R,6S)-6-[(2S,3R,4R,5S,6R)-5-[(2S,3R,4R,5R,6R)-3-acetamido-4,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-2-[(2R,3S,4R,5R,6R)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(E)-3-hydroxy-2-(octadecanoylamino)octadec-4-enoxy]oxan-3-yl]oxy-3-hy Chemical compound O[C@@H]1[C@@H](O)[C@H](OCC(NC(=O)CCCCCCCCCCCCCCCCC)C(O)\C=C\CCCCCCCCCCCCC)O[C@H](CO)[C@H]1O[C@H]1[C@H](O)[C@@H](O[C@]2(O[C@@H]([C@@H](N)[C@H](O)C2)C(O)C(O)CO[C@]2(O[C@@H]([C@@H](N)[C@H](O)C2)C(O)C(O)CO)C(O)=O)C(O)=O)[C@@H](O[C@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](CO)O1 FFILOTSTFMXQJC-QCFYAKGBSA-N 0.000 claims 1
- 125000006716 (C1-C6) heteroalkyl group Chemical group 0.000 claims 1
- BIKSKRPHKQWJCW-UHFFFAOYSA-N 3,4-dibromopyrrole-2,5-dione Chemical group BrC1=C(Br)C(=O)NC1=O BIKSKRPHKQWJCW-UHFFFAOYSA-N 0.000 claims 1
- LKKMLIBUAXYLOY-UHFFFAOYSA-N 3-Amino-1-methyl-5H-pyrido[4,3-b]indole Chemical compound N1C2=CC=CC=C2C2=C1C=C(N)N=C2C LKKMLIBUAXYLOY-UHFFFAOYSA-N 0.000 claims 1
- QBLRHWLVSHLMSP-UHFFFAOYSA-N 3-bromopyrrole-2,5-dione Chemical group BrC1=CC(=O)NC1=O QBLRHWLVSHLMSP-UHFFFAOYSA-N 0.000 claims 1
- AOJJSUZBOXZQNB-TZSSRYMLSA-N ADRIAMYCIN Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 1
- 101710027066 ALB Proteins 0.000 claims 1
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- 102100007537 CLMP Human genes 0.000 claims 1
- 101700084173 CLMP Proteins 0.000 claims 1
- 101700020447 CR2 Proteins 0.000 claims 1
- 102100009368 CR2 Human genes 0.000 claims 1
- HXCHCVDVKSCDHU-LULTVBGHSA-N Calicheamicin Chemical compound C1[C@H](OC)[C@@H](NCC)CO[C@H]1O[C@H]1[C@H](O[C@@H]2C\3=C(NC(=O)OC)C(=O)C[C@](C/3=C/CSSSC)(O)C#C\C=C/C#C2)O[C@H](C)[C@@H](NO[C@@H]2O[C@H](C)[C@@H](SC(=O)C=3C(=C(OC)C(O[C@H]4[C@@H]([C@H](OC)[C@@H](O)[C@H](C)O4)O)=C(I)C=3C)OC)[C@@H](O)C2)[C@@H]1O HXCHCVDVKSCDHU-LULTVBGHSA-N 0.000 claims 1
- 210000000234 Capsid Anatomy 0.000 claims 1
- 229940047120 Colony stimulating factors Drugs 0.000 claims 1
- 102000007644 Colony-Stimulating Factors Human genes 0.000 claims 1
- 108010071942 Colony-Stimulating Factors Proteins 0.000 claims 1
- 101710004105 DCT Proteins 0.000 claims 1
- 102100007097 DCT Human genes 0.000 claims 1
- 101700018087 DLL4 Proteins 0.000 claims 1
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- 101700039720 DPP4 Proteins 0.000 claims 1
- 102100012353 DPP4 Human genes 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- AMRJKAQTDDKMCE-UHFFFAOYSA-N Dolastatin Chemical compound CC(C)C(N(C)C)C(=O)NC(C(C)C)C(=O)N(C)C(C(C)C)C(OC)CC(=O)N1CCCC1C(OC)C(C)C(=O)NC(C=1SC=CN=1)CC1=CC=CC=C1 AMRJKAQTDDKMCE-UHFFFAOYSA-N 0.000 claims 1
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- 229940021016 Vitamin IV solution additives Drugs 0.000 claims 1
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- 150000003973 alkyl amines Chemical class 0.000 claims 1
- 239000004599 antimicrobial Substances 0.000 claims 1
- 125000006615 aromatic heterocyclic group Chemical group 0.000 claims 1
- 125000000732 arylene group Chemical group 0.000 claims 1
- 125000004429 atoms Chemical group 0.000 claims 1
- 230000001363 autoimmune Effects 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims 1
- 239000000969 carrier Substances 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
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- 125000005842 heteroatoms Chemical group 0.000 claims 1
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- 239000002105 nanoparticle Substances 0.000 claims 1
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- 229920001481 poly(stearyl methacrylate) Polymers 0.000 claims 1
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- YUOCYTRGANSSRY-UHFFFAOYSA-N pyrrolo[2,3-i][1,2]benzodiazepine Chemical class C1=CN=NC2=C3C=CN=C3C=CC2=C1 YUOCYTRGANSSRY-UHFFFAOYSA-N 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 239000002924 silencing RNA Substances 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
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- 210000004881 tumor cells Anatomy 0.000 claims 1
- 230000003612 virological Effects 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
- 229930003231 vitamins Natural products 0.000 claims 1
- 0 CC[C@](C)[C@@](C(N(C)[C@](C[C@](c1nc(C(N[C@@](CSc2ccc[s]2)C(N[C@](*CCCN*)C(N[C@@](Cc2ccccc2)C(N(CC2)CCN2C(CCCN(C(C=C2)O)C2=O)=O)=O)=O)=O)=O)c[s]1)OC(C)=O)C(C)=C)=O)NC(C1N(C)CCCC1)=O Chemical compound CC[C@](C)[C@@](C(N(C)[C@](C[C@](c1nc(C(N[C@@](CSc2ccc[s]2)C(N[C@](*CCCN*)C(N[C@@](Cc2ccccc2)C(N(CC2)CCN2C(CCCN(C(C=C2)O)C2=O)=O)=O)=O)=O)=O)c[s]1)OC(C)=O)C(C)=C)=O)NC(C1N(C)CCCC1)=O 0.000 description 5
- XYMMTUMBPMGSGQ-XUAFBCMSSA-N CC[C@H](C)[C@@H](C(N(C)[C@H](C[C@H](c1nc(C(N[C@@H](CSc2ncc[s]2)C(N[C@H](CCCCN)C(N[C@@H](Cc2ccccc2)C(N(CC2)CCN2C(CCCN(C(C=C2)O)C2=O)=O)=O)=O)=N)=O)c[s]1)OC(C)=O)C(C)=C)=O)NC([C@@H]1N(C)CCCC1)=O Chemical compound CC[C@H](C)[C@@H](C(N(C)[C@H](C[C@H](c1nc(C(N[C@@H](CSc2ncc[s]2)C(N[C@H](CCCCN)C(N[C@@H](Cc2ccccc2)C(N(CC2)CCN2C(CCCN(C(C=C2)O)C2=O)=O)=O)=O)=N)=O)c[s]1)OC(C)=O)C(C)=C)=O)NC([C@@H]1N(C)CCCC1)=O XYMMTUMBPMGSGQ-XUAFBCMSSA-N 0.000 description 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019095746A JP6842127B2 (ja) | 2019-05-22 | 2019-05-22 | 細胞毒性剤と細胞結合受容体との共役体 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019095746A JP6842127B2 (ja) | 2019-05-22 | 2019-05-22 | 細胞毒性剤と細胞結合受容体との共役体 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017057224A Division JP6585650B2 (ja) | 2017-03-23 | 2017-03-23 | 細胞毒性剤と細胞結合受容体との共役体 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021016477A Division JP7044419B2 (ja) | 2021-02-04 | 2021-02-04 | 細胞毒性剤と細胞結合受容体との共役体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019167359A JP2019167359A (ja) | 2019-10-03 |
| JP2019167359A5 true JP2019167359A5 (fr) | 2020-02-06 |
| JP6842127B2 JP6842127B2 (ja) | 2021-03-17 |
Family
ID=68106227
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019095746A Active JP6842127B2 (ja) | 2019-05-22 | 2019-05-22 | 細胞毒性剤と細胞結合受容体との共役体 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP6842127B2 (fr) |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ580132A (en) * | 2007-03-14 | 2012-11-30 | Endocyte Inc | Binding ligand linked drug delivery conjugates of tubulysins to vitamins |
| US8394922B2 (en) * | 2009-08-03 | 2013-03-12 | Medarex, Inc. | Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof |
-
2019
- 2019-05-22 JP JP2019095746A patent/JP6842127B2/ja active Active
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