JP2019162138A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019162138A5 JP2019162138A5 JP2019099354A JP2019099354A JP2019162138A5 JP 2019162138 A5 JP2019162138 A5 JP 2019162138A5 JP 2019099354 A JP2019099354 A JP 2019099354A JP 2019099354 A JP2019099354 A JP 2019099354A JP 2019162138 A5 JP2019162138 A5 JP 2019162138A5
- Authority
- JP
- Japan
- Prior art keywords
- reference value
- predetermined reference
- determined
- patient
- expression level
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000014509 gene expression Effects 0.000 claims 81
- 238000000034 method Methods 0.000 claims 25
- 238000004393 prognosis Methods 0.000 claims 23
- 206010028980 Neoplasm Diseases 0.000 claims 20
- 102100038395 Granzyme K Human genes 0.000 claims 18
- 102100036981 Interferon regulatory factor 1 Human genes 0.000 claims 18
- 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 claims 17
- 102100030386 Granzyme A Human genes 0.000 claims 17
- 102100030385 Granzyme B Human genes 0.000 claims 17
- 102100028467 Perforin-1 Human genes 0.000 claims 17
- 102000006381 STAT1 Transcription Factor Human genes 0.000 claims 17
- 102000005886 STAT4 Transcription Factor Human genes 0.000 claims 17
- 102100035794 T-cell surface glycoprotein CD3 epsilon chain Human genes 0.000 claims 17
- 102100037911 T-cell surface glycoprotein CD3 gamma chain Human genes 0.000 claims 17
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 17
- 102100025279 C-X-C motif chemokine 11 Human genes 0.000 claims 16
- 102100022087 Granzyme M Human genes 0.000 claims 16
- 102100031151 C-C chemokine receptor type 2 Human genes 0.000 claims 15
- 102100025248 C-X-C motif chemokine 10 Human genes 0.000 claims 15
- 102100025137 Early activation antigen CD69 Human genes 0.000 claims 15
- 102000003812 Interleukin-15 Human genes 0.000 claims 15
- 102100035891 T-cell surface glycoprotein CD3 delta chain Human genes 0.000 claims 15
- 102100021943 C-C motif chemokine 2 Human genes 0.000 claims 14
- 101001033007 Homo sapiens Granzyme K Proteins 0.000 claims 12
- 101000598002 Homo sapiens Interferon regulatory factor 1 Proteins 0.000 claims 12
- 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 claims 11
- 101001009599 Homo sapiens Granzyme A Proteins 0.000 claims 11
- 101001009603 Homo sapiens Granzyme B Proteins 0.000 claims 11
- 101000987581 Homo sapiens Perforin-1 Proteins 0.000 claims 11
- 101000946860 Homo sapiens T-cell surface glycoprotein CD3 epsilon chain Proteins 0.000 claims 11
- 101000738413 Homo sapiens T-cell surface glycoprotein CD3 gamma chain Proteins 0.000 claims 11
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 11
- -1 ICOS Proteins 0.000 claims 11
- 108010044012 STAT1 Transcription Factor Proteins 0.000 claims 11
- 108010019992 STAT4 Transcription Factor Proteins 0.000 claims 11
- 230000004083 survival effect Effects 0.000 claims 11
- 101000858060 Homo sapiens C-X-C motif chemokine 11 Proteins 0.000 claims 10
- 101000900697 Homo sapiens Granzyme M Proteins 0.000 claims 10
- 101000713602 Homo sapiens T-box transcription factor TBX21 Proteins 0.000 claims 10
- 102100036840 T-box transcription factor TBX21 Human genes 0.000 claims 10
- 238000010837 poor prognosis Methods 0.000 claims 10
- 238000011282 treatment Methods 0.000 claims 10
- 101710149815 C-C chemokine receptor type 2 Proteins 0.000 claims 9
- 101000858088 Homo sapiens C-X-C motif chemokine 10 Proteins 0.000 claims 9
- 101000934374 Homo sapiens Early activation antigen CD69 Proteins 0.000 claims 9
- 101000946863 Homo sapiens T-cell surface glycoprotein CD3 delta chain Proteins 0.000 claims 9
- 108090000172 Interleukin-15 Proteins 0.000 claims 9
- 238000011394 anticancer treatment Methods 0.000 claims 9
- 101000897480 Homo sapiens C-C motif chemokine 2 Proteins 0.000 claims 8
- 101150040382 CCL21 gene Proteins 0.000 claims 6
- 101150083327 CCR2 gene Proteins 0.000 claims 6
- 101150060950 CD3D gene Proteins 0.000 claims 6
- 101150093947 CD3E gene Proteins 0.000 claims 6
- 101150017312 CD3G gene Proteins 0.000 claims 6
- 101150028299 CD69 gene Proteins 0.000 claims 6
- 101150077124 CXCL10 gene Proteins 0.000 claims 6
- 101150022250 CXCL11 gene Proteins 0.000 claims 6
- 101150004010 CXCR3 gene Proteins 0.000 claims 6
- 101150087313 Cd8a gene Proteins 0.000 claims 6
- 101150001087 GZMA gene Proteins 0.000 claims 6
- 101150043363 GZMK gene Proteins 0.000 claims 6
- 101150033939 GZMM gene Proteins 0.000 claims 6
- 101150063370 Gzmb gene Proteins 0.000 claims 6
- 101100366884 Homo sapiens STAT4 gene Proteins 0.000 claims 6
- 101100260031 Homo sapiens TBX21 gene Proteins 0.000 claims 6
- 101150118672 ICOS gene Proteins 0.000 claims 6
- 101150039708 IL15 gene Proteins 0.000 claims 6
- 101150064984 Irf1 gene Proteins 0.000 claims 6
- 101150094092 STAT1 gene Proteins 0.000 claims 6
- 101150042596 STAT4 gene Proteins 0.000 claims 6
- 101150074137 TBX21 gene Proteins 0.000 claims 6
- 101150107865 prf1 gene Proteins 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 4
- 206010033128 Ovarian cancer Diseases 0.000 claims 3
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 3
- 201000011510 cancer Diseases 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010052358 Colorectal cancer metastatic Diseases 0.000 claims 2
- 102000004127 Cytokines Human genes 0.000 claims 2
- 108090000695 Cytokines Proteins 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 238000009169 immunotherapy Methods 0.000 claims 2
- 230000000683 nonmetastatic effect Effects 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 1
- 102000015696 Interleukins Human genes 0.000 claims 1
- 108010063738 Interleukins Proteins 0.000 claims 1
- 206010050017 Lung cancer metastatic Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
- 238000009098 adjuvant therapy Methods 0.000 claims 1
- 229940022399 cancer vaccine Drugs 0.000 claims 1
- 238000009566 cancer vaccine Methods 0.000 claims 1
- 201000010881 cervical cancer Diseases 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 210000002865 immune cell Anatomy 0.000 claims 1
- 239000002955 immunomodulating agent Substances 0.000 claims 1
- 230000001024 immunotherapeutic effect Effects 0.000 claims 1
- 229940047122 interleukins Drugs 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 238000009099 neoadjuvant therapy Methods 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021112781A JP7378443B2 (ja) | 2012-07-12 | 2021-07-07 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12305836.4 | 2012-07-12 | ||
| EP12305836 | 2012-07-12 | ||
| JP2015521016A JP6923291B2 (ja) | 2012-07-12 | 2013-07-12 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521016A Division JP6923291B2 (ja) | 2012-07-12 | 2013-07-12 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021112781A Division JP7378443B2 (ja) | 2012-07-12 | 2021-07-07 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019162138A JP2019162138A (ja) | 2019-09-26 |
| JP2019162138A5 true JP2019162138A5 (cg-RX-API-DMAC7.html) | 2020-02-06 |
| JP6936277B2 JP6936277B2 (ja) | 2021-09-15 |
Family
ID=48782367
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521016A Active JP6923291B2 (ja) | 2012-07-12 | 2013-07-12 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
| JP2019099354A Active JP6936277B2 (ja) | 2012-07-12 | 2019-05-28 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
| JP2021112781A Active JP7378443B2 (ja) | 2012-07-12 | 2021-07-07 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015521016A Active JP6923291B2 (ja) | 2012-07-12 | 2013-07-12 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021112781A Active JP7378443B2 (ja) | 2012-07-12 | 2021-07-07 | 少なくとも７個の遺伝子のサインを用いて、固形癌を患う患者の生存期間および処置に対する応答性を予測するための方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11242564B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2872646B1 (cg-RX-API-DMAC7.html) |
| JP (3) | JP6923291B2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK2872646T3 (cg-RX-API-DMAC7.html) |
| ES (1) | ES2648176T3 (cg-RX-API-DMAC7.html) |
| NO (1) | NO2872646T3 (cg-RX-API-DMAC7.html) |
| PL (1) | PL2872646T3 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2014009535A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO2872646T3 (cg-RX-API-DMAC7.html) * | 2012-07-12 | 2018-01-27 | ||
| WO2015077717A1 (en) | 2013-11-25 | 2015-05-28 | The Broad Institute Inc. | Compositions and methods for diagnosing, evaluating and treating cancer by means of the dna methylation status |
| US11725237B2 (en) | 2013-12-05 | 2023-08-15 | The Broad Institute Inc. | Polymorphic gene typing and somatic change detection using sequencing data |
| WO2015094992A1 (en) | 2013-12-17 | 2015-06-25 | Merck Sharp & Dohme Corp. | Ifn-gamma gene signature biomarkers of tumor response to pd-1 antagonists |
| US20160312295A1 (en) * | 2013-12-17 | 2016-10-27 | Merck Sharp & Dohme Corp. | Gene signature biomarkers of tumor response to pd-1 antagonists |
| NZ721908A (en) | 2013-12-20 | 2022-12-23 | Massachusetts Gen Hospital | Combination therapy with neoantigen vaccine |
| AU2015304448B2 (en) * | 2014-08-19 | 2020-04-30 | National University Corporation Okayama University | Method for enhancing immune cell function and method for assessing immune cell multifunctionality |
| WO2016049276A1 (en) * | 2014-09-25 | 2016-03-31 | Moffitt Genetics Corporation | Prognostic tumor biomarkers |
| WO2016073378A1 (en) | 2014-11-03 | 2016-05-12 | Genentech, Inc. | Assays for detecting t cell immune subsets and methods of use thereof |
| CN107109484B (zh) * | 2014-11-03 | 2021-12-14 | 豪夫迈·罗氏有限公司 | 用于ox40激动剂治疗的功效预测和评估的方法和生物标志物 |
| AU2015360736A1 (en) | 2014-12-09 | 2017-06-01 | Merck Sharp & Dohme Corp. | System and methods for deriving gene signature biomarkers of response to PD-1 antagonists |
| US10975442B2 (en) | 2014-12-19 | 2021-04-13 | Massachusetts Institute Of Technology | Molecular biomarkers for cancer immunotherapy |
| US10993997B2 (en) | 2014-12-19 | 2021-05-04 | The Broad Institute, Inc. | Methods for profiling the t cell repertoire |
| DK3273992T3 (da) | 2015-03-23 | 2020-07-27 | Jounce Therapeutics Inc | Antistoffer mod ICOS |
| EP3073268A1 (en) | 2015-03-27 | 2016-09-28 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | Biomarker panel for diagnosing cancer |
| ES2844799T5 (en) | 2015-04-17 | 2025-01-16 | Merck Sharp & Dohme Llc | Blood-based biomarkers of tumor sensitivity to pd-1 antagonists |
| KR20180010229A (ko) | 2015-05-20 | 2018-01-30 | 더 브로드 인스티튜트, 인코퍼레이티드 | 공유 신생항원 |
| WO2017065000A1 (ja) * | 2015-10-15 | 2017-04-20 | 国立大学法人京都大学 | Ｐｄ－１経路阻害薬の著効例を予測するためのバイオマーカー |
| KR20180066236A (ko) * | 2015-10-22 | 2018-06-18 | 조운스 테라퓨틱스, 인크. | Icos 발현을 계측하기 위한 유전자 특질 |
| WO2017096458A1 (en) * | 2015-12-07 | 2017-06-15 | Ontario Institute For Cancer Research (Oicr) | Immune gene signature predictive of anthracycline benefit |
| CA3020026A1 (en) * | 2016-04-15 | 2017-10-19 | Trillium Therapeutics Inc. | Macrophage stimulation in cd47 blockade therapy |
| MX393482B (es) * | 2016-05-09 | 2025-03-24 | Inst Nat Sante Rech Med | Metodos para clasificar pacientes con un cancer solido |
| EP3487522A4 (en) * | 2016-07-19 | 2020-04-01 | Teva Pharmaceuticals Australia Pty Ltd | Anti-cd47 combination therapy |
| WO2018045346A1 (en) * | 2016-09-01 | 2018-03-08 | Autotelic Llc | Methods for treating cancer and determining efficacy of treatment |
| EP3574116A1 (en) | 2017-01-24 | 2019-12-04 | The Broad Institute, Inc. | Compositions and methods for detecting a mutant variant of a polynucleotide |
| ES2953595T3 (es) | 2017-03-01 | 2023-11-14 | Hoffmann La Roche | Procedimientos diagnósticos y terapéuticos para el cáncer |
| JP2020523022A (ja) * | 2017-06-14 | 2020-08-06 | アイカーン スクール オブ メディシン アット マウント サイナイ | 免疫療法に反応する肝細胞癌のクラスの検出および治療方法 |
| WO2018232320A2 (en) * | 2017-06-16 | 2018-12-20 | Nantomics, Llc | Prognostic indicators of poor outcomes in praegnant metastatic breast cancer cohort |
| BR112021024374A8 (pt) | 2019-06-03 | 2022-12-06 | Inst Nat Sante Rech Med | Método para modular um regime de tratamento |
| EP4055609A1 (en) | 2019-11-07 | 2022-09-14 | Oncxerna Therapeutics, Inc. | Classification of tumor microenvironments |
| EP4126945A4 (en) | 2020-04-01 | 2024-02-28 | Avalo Therapeutics, Inc. | Methods and treatment involving excess free light |
| GB202007099D0 (en) | 2020-05-14 | 2020-07-01 | Kymab Ltd | Tumour biomarkers for immunotherapy |
| JP2023531201A (ja) * | 2020-06-18 | 2023-07-21 | マクロジェニクス，インコーポレーテッド | 血液悪性腫瘍の治療のための二重特異性ｃｄ１２３×ｃｄ３ダイアボディの使用 |
| EP4172621A1 (en) * | 2020-06-30 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the risk of recurrence and/or death of patients suffering from a solid cancer after preoperative adjuvant therapies |
| JP7741831B2 (ja) | 2020-06-30 | 2025-09-18 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 術前補助療法及び根治手術後の固形がんを患っている患者の再発及び／又は死亡のリスクを予測するための方法 |
| CA3245129A1 (en) | 2022-03-17 | 2023-09-21 | Universite Paris Cite | METHODS FOR PREDICTING RESPONSE TO IMMUNOTHERAPEUTIC TREATMENT IN A CANCER PATIENT |
Family Cites Families (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4888278A (en) | 1985-10-22 | 1989-12-19 | University Of Massachusetts Medical Center | In-situ hybridization to detect nucleic acid sequences in morphologically intact cells |
| US6280929B1 (en) | 1986-01-16 | 2001-08-28 | The Regents Of The University Of California | Method of detecting genetic translocations identified with chromosomal abnormalities |
| US5447841A (en) | 1986-01-16 | 1995-09-05 | The Regents Of The Univ. Of California | Methods for chromosome-specific staining |
| US4774339A (en) | 1987-08-10 | 1988-09-27 | Molecular Probes, Inc. | Chemically reactive dipyrrometheneboron difluoride dyes |
| US5132432A (en) | 1989-09-22 | 1992-07-21 | Molecular Probes, Inc. | Chemically reactive pyrenyloxy sulfonic acid dyes |
| US5274113A (en) | 1991-11-01 | 1993-12-28 | Molecular Probes, Inc. | Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates |
| US5433896A (en) | 1994-05-20 | 1995-07-18 | Molecular Probes, Inc. | Dibenzopyrrometheneboron difluoride dyes |
| US5248782A (en) | 1990-12-18 | 1993-09-28 | Molecular Probes, Inc. | Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes |
| US5338854A (en) | 1991-02-13 | 1994-08-16 | Molecular Probes, Inc. | Fluorescent fatty acids derived from dipyrrometheneboron difluoride dyes |
| US5427932A (en) | 1991-04-09 | 1995-06-27 | Reagents Of The University Of California | Repeat sequence chromosome specific nucleic acid probes and methods of preparing and using |
| US5187288A (en) | 1991-05-22 | 1993-02-16 | Molecular Probes, Inc. | Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis |
| US5262357A (en) | 1991-11-22 | 1993-11-16 | The Regents Of The University Of California | Low temperature thin films formed from nanocrystal precursors |
| US5505928A (en) | 1991-11-22 | 1996-04-09 | The Regents Of University Of California | Preparation of III-V semiconductor nanocrystals |
| US6048616A (en) | 1993-04-21 | 2000-04-11 | Philips Electronics N.A. Corp. | Encapsulated quantum sized doped semiconductor particles and method of manufacturing same |
| US5472842A (en) | 1993-10-06 | 1995-12-05 | The Regents Of The University Of California | Detection of amplified or deleted chromosomal regions |
| US5595756A (en) * | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| US5571018A (en) | 1994-11-23 | 1996-11-05 | Motorola, Inc. | Arrangement for simulating indirect fire in combat training |
| US5690807A (en) | 1995-08-03 | 1997-11-25 | Massachusetts Institute Of Technology | Method for producing semiconductor particles |
| US5800996A (en) | 1996-05-03 | 1998-09-01 | The Perkin Elmer Corporation | Energy transfer dyes with enchanced fluorescence |
| US5830912A (en) | 1996-11-15 | 1998-11-03 | Molecular Probes, Inc. | Derivatives of 6,8-difluoro-7-hydroxycoumarin |
| US5696157A (en) | 1996-11-15 | 1997-12-09 | Molecular Probes, Inc. | Sulfonated derivatives of 7-aminocoumarin |
| US5866366A (en) | 1997-07-01 | 1999-02-02 | Smithkline Beecham Corporation | gidB |
| US6130101A (en) | 1997-09-23 | 2000-10-10 | Molecular Probes, Inc. | Sulfonated xanthene derivatives |
| US6322901B1 (en) | 1997-11-13 | 2001-11-27 | Massachusetts Institute Of Technology | Highly luminescent color-selective nano-crystalline materials |
| US5990479A (en) | 1997-11-25 | 1999-11-23 | Regents Of The University Of California | Organo Luminescent semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| US6207392B1 (en) | 1997-11-25 | 2001-03-27 | The Regents Of The University Of California | Semiconductor nanocrystal probes for biological applications and process for making and using such probes |
| US6617583B1 (en) | 1998-09-18 | 2003-09-09 | Massachusetts Institute Of Technology | Inventory control |
| US6114038A (en) | 1998-11-10 | 2000-09-05 | Biocrystal Ltd. | Functionalized nanocrystals and their use in detection systems |
| US6855202B2 (en) | 2001-11-30 | 2005-02-15 | The Regents Of The University Of California | Shaped nanocrystal particles and methods for making the same |
| DE60042738D1 (de) | 1999-05-07 | 2009-09-24 | Life Technologies Corp | Verfahren zum nachweis von analyten mit hilfe von halbleiternanokrystallen |
| US6306736B1 (en) | 2000-02-04 | 2001-10-23 | The Regents Of The University Of California | Process for forming shaped group III-V semiconductor nanocrystals, and product formed using process |
| US6225198B1 (en) | 2000-02-04 | 2001-05-01 | The Regents Of The University Of California | Process for forming shaped group II-VI semiconductor nanocrystals, and product formed using process |
| WO2001071043A1 (en) | 2000-03-22 | 2001-09-27 | Quantum Dot Corporation | Loop probe hybridization assay for polynucleotide analysis |
| US6689338B2 (en) | 2000-06-01 | 2004-02-10 | The Board Of Regents For Oklahoma State University | Bioconjugates of nanoparticles as radiopharmaceuticals |
| EP1311487B1 (en) | 2000-08-04 | 2008-11-26 | Molecular Probes, Inc. | Derivatives of 1,2-dihydro-7-hydroxyquinolines containing fused rings |
| US6942970B2 (en) | 2000-09-14 | 2005-09-13 | Zymed Laboratories, Inc. | Identifying subjects suitable for topoisomerase II inhibitor treatment |
| US6649138B2 (en) | 2000-10-13 | 2003-11-18 | Quantum Dot Corporation | Surface-modified semiconductive and metallic nanoparticles having enhanced dispersibility in aqueous media |
| US20020083888A1 (en) | 2000-12-28 | 2002-07-04 | Zehnder Donald A. | Flow synthesis of quantum dot nanocrystals |
| US6670113B2 (en) | 2001-03-30 | 2003-12-30 | Nanoprobes | Enzymatic deposition and alteration of metals |
| US6709929B2 (en) | 2001-06-25 | 2004-03-23 | North Carolina State University | Methods of forming nano-scale electronic and optoelectronic devices using non-photolithographically defined nano-channel templates |
| EP2218762A3 (en) | 2001-07-20 | 2010-09-29 | Life Technologies Corporation | Luminescent nanoparticles and methods for their preparation |
| WO2004037996A2 (en) * | 2002-10-24 | 2004-05-06 | Duke University | Evaluation of breast cancer states and outcomes using gene expression profiles |
| WO2005005601A2 (en) * | 2003-06-09 | 2005-01-20 | The Regents Of The University Of Michigan | Compositions and methods for treating and diagnosing cancer |
| US7642064B2 (en) | 2003-06-24 | 2010-01-05 | Ventana Medical Systems, Inc. | Enzyme-catalyzed metal deposition for the enhanced detection of analytes of interest |
| JP4648902B2 (ja) | 2003-06-24 | 2011-03-09 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | 免疫組織化学的エピトープおよび核酸配列のインサイチュ検出が向上するように酵素の触媒作用で金属を付着 |
| US20060246523A1 (en) | 2005-04-28 | 2006-11-02 | Christopher Bieniarz | Antibody conjugates |
| JP2008541015A (ja) | 2005-04-28 | 2008-11-20 | ベンタナ・メデイカル・システムズ・インコーポレーテツド | ナノ粒子コンジュゲート |
| EP3530736A3 (en) * | 2005-05-09 | 2019-11-06 | ONO Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
| EP1777523A1 (en) * | 2005-10-19 | 2007-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method |
| WO2007062177A2 (en) | 2005-11-23 | 2007-05-31 | Ventana Medical Systems, Inc. | Molecular conjugate |
| WO2007072225A2 (en) * | 2005-12-01 | 2007-06-28 | Medical Prognosis Institute | Methods and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy |
| EP2032719A2 (en) * | 2006-06-02 | 2009-03-11 | GlaxoSmithKline Biologicals S.A. | Method for identifying whether a patient will be responder or not to immunotherapy |
| WO2009091659A2 (en) * | 2008-01-16 | 2009-07-23 | Shi-Lung Lin | Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant rna agents |
| WO2010144192A1 (en) * | 2009-05-05 | 2010-12-16 | Children's Medical Center Corporation | Prognosis indicators for solid human tumors |
| EP2757160A3 (en) * | 2009-07-20 | 2014-07-30 | Genentech, Inc. | Gene expression markers for Crohn's disease |
| CN102858999A (zh) * | 2009-12-01 | 2013-01-02 | 简要生物科学有限公司 | 癌症的分类 |
| US9404926B2 (en) * | 2010-01-29 | 2016-08-02 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Immune gene signatures in cancer |
| NO2872646T3 (cg-RX-API-DMAC7.html) * | 2012-07-12 | 2018-01-27 |
-
2013
- 2013-07-12 NO NO13735334A patent/NO2872646T3/no unknown
- 2013-07-12 ES ES13735334.8T patent/ES2648176T3/es active Active
- 2013-07-12 DK DK13735334.8T patent/DK2872646T3/en active
- 2013-07-12 WO PCT/EP2013/064808 patent/WO2014009535A2/en not_active Ceased
- 2013-07-12 US US14/413,856 patent/US11242564B2/en active Active
- 2013-07-12 JP JP2015521016A patent/JP6923291B2/ja active Active
- 2013-07-12 PL PL13735334T patent/PL2872646T3/pl unknown
- 2013-07-12 EP EP13735334.8A patent/EP2872646B1/en active Active
-
2019
- 2019-05-28 JP JP2019099354A patent/JP6936277B2/ja active Active
-
2021
- 2021-07-07 JP JP2021112781A patent/JP7378443B2/ja active Active
- 2021-12-27 US US17/562,111 patent/US12291752B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019162138A5 (cg-RX-API-DMAC7.html) | ||
| JP2015528698A5 (cg-RX-API-DMAC7.html) | ||
| Ye et al. | Tumor-infiltrating immune cells act as a marker for prognosis in colorectal cancer | |
| Kidman et al. | Characteristics of TCR repertoire associated with successful immune checkpoint therapy responses | |
| Yao et al. | Prognostic value of novel immune-related genomic biomarkers identified in head and neck squamous cell carcinoma | |
| Wang et al. | Correlate tumor mutation burden with immune signatures in human cancers | |
| Awasthi et al. | Comparative genomics reveals distinct immune-oncologic pathways in African American men with prostate cancer | |
| Wei et al. | Clinically relevant cytotoxic immune cell signatures and clonal expansion of T-cell receptors in high-risk MYCN-not-amplified human neuroblastoma | |
| Araujo et al. | Effect of CCL5 expression in the recruitment of immune cells in triple negative breast cancer | |
| Wang et al. | Circulating activated lymphocyte subsets as potential blood biomarkers of cancer progression | |
| Speers et al. | Development and validation of a novel radiosensitivity signature in human breast cancer | |
| Kotoula et al. | Tumors with high-density tumor infiltrating lymphocytes constitute a favorable entity in breast cancer: a pooled analysis of four prospective adjuvant trials | |
| Wu et al. | The chemokine CXCL9 expression is associated with better prognosis for colorectal carcinoma patients | |
| Nguyen et al. | Inflammatory and microRNA gene expression as prognostic classifier of Barrett's-associated esophageal adenocarcinoma | |
| EP3695014B1 (en) | Prognostic and treatment response predictive method | |
| Cheng et al. | Validation of the 18-gene classifier as a prognostic biomarker of distant metastasis in breast cancer | |
| Egelston et al. | Tumor-infiltrating exhausted CD8+ T cells dictate reduced survival in premenopausal estrogen receptor–positive breast cancer | |
| Moosavi et al. | De novo transcriptomic subtyping of colorectal cancer liver metastases in the context of tumor heterogeneity | |
| JP2019516979A5 (cg-RX-API-DMAC7.html) | ||
| Pitroda et al. | Tumor endothelial inflammation predicts clinical outcome in diverse human cancers | |
| Morris et al. | Chronic macrophage migration inhibitory factor exposure induces mesenchymal epithelial transition and promotes gastric and colon cancers | |
| Gardner et al. | A distinct innate immune signature of early onset colorectal cancer | |
| Hossain et al. | Innate immune checkpoint inhibitor resistance is associated with melanoma sub-types exhibiting invasive and de-differentiated gene expression signatures | |
| Jung et al. | Mutation of the TERT promoter leads to poor prognosis of patients with non‑small cell lung cancer | |
| Chen et al. | Tumor microenvironment characterization for assessment of recurrence and survival outcome in gastric cancer to predict chemotherapy and immunotherapy response |