JP2019097885A - Applicator - Google Patents

Abstract

To provide an applicator capable of suppressing rebound of a microneedle due to an elastic force of a skin when the microneedle punctures the skin.SOLUTION: A second piston 36 provided inside a holder 30 is punched out when it is pushed out by a first piston 16 punched out toward one axial end side by a biasing force of a biasing member 14 by releasing temporary fixing of a lever member 18, and thereby an applicator 10 causes a plurality of microneedles 38 to puncture a skin. Inside the holder 30, there is provided restricting means 40 for restricting movement of the second piston 36 to the other axial end side after the second piston 36 abuts on the skin. The restricting means 40 has at least three locking portions 34 provided at equal intervals on the peripheral edge of the second piston 36, and a locked portion 32 formed on an inner peripheral surface of the holder 30 on which the locking portion 34 abuts in a direction opposite to a punching-out direction of the second piston 36.SELECTED DRAWING: Figure 1

Description

  The present disclosure relates to an applicator.

  In recent years, a microneedle (hereinafter referred to as “microneedle”) containing a drug solution is provided on a percutaneous absorption sheet, and the method of puncturing the skin with the microneedle with an applicator efficiently delivers drug solution without causing pain to the human body. It is noted because it can be administered into the body.

  As the applicator, for example, in a cylindrical housing, a piston for transmitting the biasing force of the biasing member to the microneedle, and a fixing means for fixing the piston against the biasing force of the biasing member are provided. There are some examples (see, for example, Patent Document 1). According to this applicator, when the piston fixed by the fixing means is released by the release mechanism, the biasing force of the biasing member ejects the piston and punctures the microneedle into the skin.

International Publication No. 2012/46816

  However, in such an applicator, when the microneedle is punctured into the skin by the biasing force of the biasing member, the microneedle may be rebounded by the elastic force of the skin. When the microneedle rebounds, the microneedle may come off the skin or the microneedle may be inclined, and the puncture depth may not be stably maintained, so that the drug solution dose may become unstable.

  Then, this indication aims at obtaining the applicator which can control that a microneedle rebounds by the elastic force of skin, when a microneedle punctures a skin.

  In order to achieve the above object, the applicator according to the present disclosure is provided with a cylindrical main body, a biasing member provided inside the main body, and the inside of the main body, and one axial end of the main body by the biasing member Provided at the other end of the main body in the axial direction of the main body, a lever member for pulling the first piston toward the other axial end of the main body against the urging force of the urging member, A temporary fixing member for temporarily fixing the lever member in a state in which the first piston is pulled up, a cylindrical holder provided detachably at one axial end of the main body, and a plurality of microneedles on the surface facing the skin It is attached and provided in the inside of the holder, and is released by the biasing force of the biasing member by releasing the temporary fixing of the lever member, thereby pushing it out to the first piston punched out toward the one end in the axial direction. The second shot And a restricting means provided inside the holder for restricting the movement of the second piston to the other axial end side after the second piston strikes the skin, wherein the restricting means is the second piston And at least three locking portions provided at equal intervals in the peripheral edge portion of the holder, and a locking portion formed on the inner peripheral surface of the holder, the locking portion being in contact from the direction opposite to the striking-out direction of the second piston Have.

  According to the present disclosure, when the microneedle punctures the skin, the elastic force of the skin can suppress the rebound of the microneedle by the restriction means.

It is a front view which shows the state which pulled up the lever member of the applicator which concerns on this embodiment. It is a front view which shows the state which released the lever member of the applicator which concerns on this embodiment, and knocked out the 2nd piston. It is an exploded perspective view of an applicator concerning this embodiment. It is a top view which shows the groove part and slope of an applicator which concern on this embodiment. It is a top view which shows the modification of the groove part and slope of the applicator which concern on this embodiment. It is a partially expanded sectional view which shows the cyclic | annular protrusion and nail | claw part of the applicator which concerns on this embodiment. It is a perspective view which shows the nail-like member of the applicator which concerns on this embodiment. It is a perspective view which shows typically the microneedle provided in the lower surface of the 2nd piston of the applicator which concerns on this embodiment. It is a perspective view which shows the holder to which the holder of the applicator which concerns on this embodiment is attached. It is a perspective view which shows the modification of the nail-like member of the applicator which concerns on this embodiment.

  Hereinafter, embodiments according to the present disclosure will be described in detail based on the drawings. In addition, for convenience of explanation, the arrow UP shown in FIG. 1 and FIG. 2 is an upward direction, and the axial direction other end side of the main body 12 to be described later is set. Therefore, the axial direction one end side in the main body 12 is downward. Further, in the present embodiment, a case where a microneedle 38 described later is punctured in a human arm will be described as an example. Further, the microneedle 38 is of a self-dissolving type or a chemical solution coating type, but in the present embodiment, a self-dissolving type is taken as an example. However, the form of the microneedles 38 is not limited to this.

  As shown in FIGS. 1 to 3, the applicator 10 according to the present embodiment is a substantially cylindrical tack that is detachably attached by being screwed to the cylindrical body 12 and the upper end of the body 12. A member 20 and a cylindrical holder 30 detachably attached by being fitted to the lower end portion of the main body 12 are provided.

  The main body 12 (including the first piston 16 described later), the temporary fixing member 20, and the holder 30 (including the second piston 36 described later) are preferably made of resin that is lightweight and has a low coefficient of friction, for example, poly It is preferable to be formed of tetrafluoroethylene (PTFE).

  A coil spring 14 as a biasing member and a cylindrical first piston 16 are provided in the inside of the main body 12 in order from the top, and the first piston 16 is attached with the coil spring 14 as described later. The force is designed to be driven downward to the main body 12. The outer diameter of the first piston 16 is substantially the same as the inner diameter of the main body 12 (inner diameter of the main body 12-outer diameter of the first piston = 0.02 mm to 0.06 mm), and the outer diameter of the coil spring 14 Is formed slightly smaller than the inner diameter of the main body 12.

  The lower end portion of the lever member 18 is attached to the axial center portion of the upper end portion of the first piston 16. That is, a screw hole portion 16A as a female screw portion is formed in an axial center portion at an upper end portion of the first piston 16, and a male screw portion 18A is formed in a lower end portion of the lever member 18.

  Therefore, the male screw portion 18A of the lever member 18 is screwed into the screw hole portion 16A of the first piston 16, whereby the first piston 16 is integrally attached to the lower end portion of the lever member 18. The lower end portion of the lever member 18 and the axial center portion (upper end portion) of the first piston 16 may be attached by other attachment means. The first piston 16 is configured to be pulled up to the upper side of the main body 12 against the biasing force of the coil spring 14 by the lever member 18.

  Further, as shown in FIG. 1, air is taken into the inside of the main body 12 as the first piston 16 is pulled up to the peripheral wall of the main body 12, and is present inside the main body 12 as the first piston 16 is punched out. The two intake and exhaust ports 12A and 12B for discharging the air are formed vertically separated from each other. Although the upper air intake / exhaust port 12A and the lower air intake / exhaust port 12B are each formed in a substantially elliptical shape long in the vertical direction, the present invention is not particularly limited to this shape.

  As shown in FIGS. 1 to 3, the temporary fixing member 20 temporarily holds the lever member 18 in a state in which the first piston 16 is pulled up against the biasing force of the coil spring 14. An upper end portion of the lever member 18 is an operation portion 19 bent at a right angle with respect to the axial direction of the main body 12. Then, in the peripheral wall of the temporary fixing member 20, the slit portion 24 which passes through the operation portion 19 in the axial direction communicates with the through hole 22 formed in the axial center portion for passing the lever member 18 except the operation portion 19 It is formed along the

  In addition, as shown in FIG. 4, the upper end surface of the temporary fixing member 20 and the position which is shifted by about 90 degrees in the circumferential direction from the slit part 24, the cross section of the “V” shape holding the operation part 19 Alternatively, a groove 26 having a semicircular cross section is formed to extend in the radial direction. Then, on the upper end surface of the temporary fixing member 20 and between the groove portion 26 and the slit portion 24, a slope 28 as a downward inclined surface for guiding the operation portion 19 removed from the groove portion 26 to the slit portion 24 is formed. There is.

  The groove portion 26 and the slope 28 may be formed on one side in the circumferential direction with respect to the slit portion 24 as shown in FIG. 4, but as shown in FIG. It may be formed on both sides in the circumferential direction (in FIG. 1 to FIG. 3, it is shown that the slopes 28 are formed on one side and the grooves 26 are formed on both sides). Moreover, although the inner wall of the through-hole 22 of illustration is formed in rectangular shape by planar view, it may be formed in semicircle shape by planar view.

  Further, as shown in FIGS. 1 to 3, a male screw 21 having the through hole 22 as a rotation center is integrally formed at the lower end of the temporary fixing member 20, and the upper end of the main body 12 is The female screw portion 13 is formed in which the male screw portion 21 is screwed. That is, the temporary fixing member 20 is attached by screwing so that the temporary fixing member 20 can be easily removed from the main body 12, and can be replaced with one having a different length in the axial direction.

  Thereby, it is possible to adjust the biasing force of the coil spring 14 when pushing out the first piston 16 (the amount by which the coil spring 14 is shrunk, and the compression energy). The temporary fixing member 20 only needs to be easily removable from the main body 12 and is not limited to the attachment means by screwing as shown.

  Further, as shown in FIGS. 1 to 3, an enlarged diameter portion 15 is formed at the lower end portion of the main body 12, and the upper end portion of the holder 30 is detachably attachable radially inside the enlarged diameter portion 15. It is supposed to be fitted. That is, the claw portion 15A is formed in the circumferential direction at the lower end portion of the inner peripheral surface of the enlarged diameter portion 15, and the groove portion in which the claw portion 15A is fitted at the upper end portion of the outer peripheral surface of the holder 30 31 (see also FIG. 6) are formed in the circumferential direction. Thereby, the holder 30 is configured to be centered and attached to the main body 12.

  Further, on the inner peripheral surface of the holder 30 (specifically, the region from the upper end surface of the holder 30 to about 2/3 of the entire length), an annular protrusion 32 as an engaged portion along the circumferential direction is axially A plurality is formed side by side. And, as shown in FIG. 6, the lower surface 32A as the stopper surface of the annular projection 32 is a flat surface facing the axial direction (preferably, the axial direction is the normal direction), and the upper surface of the annular projection 32 is 32B is a downward slope toward the axial center side (radially inward).

  The lower surface 32A of the annular projection 32 has an angle (perpendicular to the axial direction) such that the tip 34A of the claw 34 does not elastically deform toward the axial center when the tip 34A of the claw 34 described later comes into contact. It may be projected radially inward at an angle with respect to the surface to be processed. In addition, an intake and exhaust port (not shown) may be formed on the peripheral wall of the holder 30 below the annular projection 32.

  Further, as shown in FIGS. 1 to 3, a second piston 36 is provided inside the holder 30. The second piston 36 has a two-step cylindrical shape in which the upper side is a large diameter portion 36A having an outer diameter substantially the same as the inner diameter of the holder 30, and the lower side is a small diameter portion 36B having an outer diameter smaller than the large diameter portion 36A. It is formed. A metal (for example, stainless steel) claw 33 is provided on the upper surface of the large diameter portion 36A of the second piston 36 with the annular projection 32 and the claw 34 as a locking portion constituting the regulating means 40. It is done.

  As shown in FIG. 7, the claw-like members 33 are a plurality of (three or more, for example, eighteen) claws integrally erected obliquely upward at equal intervals from the outer peripheral edge of the flat ring-shaped base 35. It has 34. Each of the claws 34 is elastically deformed toward the axial center side by being pushed toward the axial center side (radially inward) by the annular projection 32 with at least the tip 34A being moved downward of the second piston 36 It is possible.

  Then, as shown in FIG. 6, the tip 34A of the claw 34 hits the lower surface 32A of the annular projection 32 from the lower side (in the direction opposite to the direction in which the second piston 36 is ejected). The upward rebound (movement) of the second piston 36 is restricted. Therefore, it is preferable that the tip end 34A of the claw portion 34 be flat so as to properly hit the lower surface 32A of the annular projection 32 (see FIG. 7).

  As shown in FIG. 6, the rising angle θ1 of the claw portion 34 with respect to the base 35 is, for example, θ1 = 76 degrees. The inclination angle θ2 of the upper surface 32B with respect to the lower surface 32A of the annular projection 32 is, for example, θ2 = 45 degrees. Further, the radially inward protrusion amount φ of the annular protrusion 32 is, for example, φ = 0.25 mm, and the axial distance D of the annular protrusion 32 is, for example, D = 0.4 mm. It is done.

  Further, at the center of the upper surface of the large diameter portion 36A of the second piston 36, a circular convex portion 37 having the same outer diameter as the inner diameter of the circular through hole 35A formed in the axial center portion of the base 35 (FIG. 3) (See) is provided. Therefore, the base 35 is bonded to the upper surface thereof with an adhesive or the like in a state in which the through hole 35A is fitted to the convex portion 37 of the second piston 36. That is, the claw-like member 33 is centered on the upper surface of the second piston 36 and attached.

  Further, as shown in FIG. 8, on the lower surface (the surface facing the skin) of the small diameter portion 36B of the second piston 36, a percutaneous absorption sheet 39 having a plurality (for example, 100) of micro microneedles 38 is provided. It is attached. The microneedle 38 has a height of, for example, 100 μm to 500 μm, and dissolves when a predetermined time elapses in a state of being punctured in the skin, and the drug solution is administered into the body.

  Therefore, as shown in FIG. 9, the holder 30 is integrally provided, for example, on a holder 42 for winding around a human arm. The holder 42 includes an upper half 44 attached to the lower end of the outer peripheral surface of the holder 30, a lower half 46 facing the upper half 44, longitudinal ends of the upper half 44 and longitudinal ends of the lower half 46. And a pair of cloth-like tape members 48 which connect the length-adjustablely.

  At the central portion of the upper half 44, a circular opening (not shown) through which at least the small diameter portion 36B of the second piston 36 is inserted is formed. Also, the tape member 48 is configured by a surface fastener. Therefore, by inserting an arm between the upper half 44 and the lower half 46 of the holder 42 and adjusting the winding force on the arm with the tape member 48, the holder to which the temporary fixing member 20 and the main body 12 are attached 30, the applicator 10 is to be secured to the arm.

  In addition, after puncturing the microneedle 38, the main body 12 including the temporary fixing member 20 is removed from the holder 30, and the holder 30 remains fixed to the arm until the medical fluid is administered into the body by the microneedle 38. It is supposed to be Therefore, it is preferable that the holder 30 and the second piston 36 be transparent so that the drug administration state can be known.

  Further, as shown in FIGS. 1 and 2, when the free length of the coil spring 14 is L1, the total length of the coil spring 14 when contracted is L2, and the movement amount of the first piston 16 is X, L1 <L2 + X is satisfied. It is supposed to meet. That is, as shown in FIG. 2, after the first piston 16 is punched out, the upper end surface of the first piston 16 is separated from the lower end surface of the coil spring 14, and the lower end surface of the coil spring 14 and the first piston A gap S is formed between the upper end surface 16 and the upper surface.

  Next, the operation of the applicator 10 configured as described above will be described.

  When using the applicator 10 in order to puncture the microneedles 38 into the skin, the temporary fixing member 20 of an appropriate length is screwed on and attached to the upper end of the main body 12 first. Next, the operation portion 19 (lever member 18), which is passed through the slit portion 24 of the temporary fixing member 20 and locked to the upper end surface of the main body 12, is pulled up against the biasing force of the coil spring 14 with fingers. That is, the first piston 16 is pulled up against the biasing force of the coil spring 14.

  Then, when the operation portion 19 is pulled up to the upper end surface of the temporary fixing member 20, the operation portion 19 is rotated approximately 90 degrees and fitted in the groove portion 26. As the first piston 16 is pulled up, air is sucked into the main body 12 from the lower air intake and exhaust port 12B, and the air in the main body 12 is discharged from the upper air intake and exhaust port 12A. Thereby, even if the inner diameter of the main body 12 and the outer diameter of the first piston 16 are substantially the same, the first piston 16 can be pulled up smoothly (without rattling) without receiving compression resistance.

  Meanwhile, the holder 30 is attached to the arm. That is, an arm is inserted between the upper half 44 and the lower half 46 of the holder 42, and the winding force is adjusted and fixed by the tape member 48. A plurality of (three or more) claws 34 are provided at equal intervals on the outer peripheral edge of the upper surface inside the holder 30, and a percutaneous absorption sheet 39 having the microneedles 38 is provided on the lower surface. The two pistons 36 are inserted in advance from above.

  After the holder 30 is fixed to the arm, the enlarged diameter portion 15 (the claw portion 15A) of the main body 12 is fitted from the radially outer side to the upper end portion (the groove portion 31) of the holder 30 to hold the main body 12 including the temporary fixing member 20 Attach to 30. The applicator 10 is then ready to puncture the microneedles 38 into the skin.

  When the microneedle 38 is punctured into the skin by the applicator 10, the temporary fixing of the lever member 18 is released. That is, the operation portion 19 of the lever member 18 is removed from the groove 26 and slid along the slope 28. When such a slope 28 is formed on the upper end surface of the temporary fixing member 20, the operation portion 19 is smoothly guided to the slit portion 24.

  Then, when the operation portion 19 reaches the slit portion 24, the operation portion 19 falls to the upper end surface of the main body 12 through the slit portion 24 by the biasing force of the coil spring 14. That is, the first piston 16 is driven downward by the biasing force of the coil spring 14, and the upper surface of the convex portion 37 of the second piston 36 and the upper surface of the base 35 are hit to push the second piston 36 downward. In other words, the second piston 36 is driven downward by the first piston 16.

  It should be noted that as the first piston 16 punches out, the air in the main body 12 is discharged from the lower air suction and discharge port 12B, and the air is sucked into the main body 12 from the upper air suction and discharge port 12A. Thereby, even if the inner diameter of the main body 12 and the outer diameter of the first piston 16 are substantially the same, the first piston 16 is ejected downward (without rattling) smoothly without receiving compression resistance.

  Further, since the upper surface 32B of the annular projection 32 is a downward inclined surface (with the inclination angle θ2 = 45 degrees), the claw portion 34 smoothly moves to the axial center side with the downward movement of the second piston 36. It can be elastically deformed. Therefore, even in the configuration in which the restricting means 40 (the annular projection 32 and the claw portion 34) is provided, the second piston 36 is ejected downward (without rattling) smoothly.

Here, in the applicator 10 according to the present embodiment, as described above, L1 <L2 + X is satisfied. Therefore, the biasing force (compression energy) of the coil spring 14 is all converted into kinetic energy (puncture energy) for puncture and transmitted to the second piston 36. That is, when the mass of M of the first piston 16, the speed of the V of the first piston 16, the elastic force of the skin K, the skin deflection (= lancing depth) was ^{Y, MV 2/2 = KY} 2 / Meet 2 Therefore, the energy loss of the biasing force (compression energy) in the coil spring 14 can be minimized.

  Thus, the second piston 36 punched downward (skin) by the impact of the first piston 16 punctures the skin with the microneedle 38 provided on the lower surface thereof. Here, a plurality (three or more) of claw portions 34 are provided at equal intervals on the outer peripheral edge portion of the upper surface of the second piston 36. Further, on the inner peripheral surface of the holder 30, a plurality of annular protrusions 32 along the circumferential direction are formed in line in the axial direction, and the lower surface 32A of the annular protrusion 32 faces substantially in the axial direction (preferably the axial direction is It is considered as a plane).

  Therefore, when the second piston 36 punched out toward the skin tries to hit the skin and rebounds, the tip 34A of the claw 34 strikes the lower surface 32A of any of the plurality of annular projections 32 axially aligned from below, Rebound (movement upward) of the second piston 36 is prevented. Thus, the microneedles 38 can be prevented from coming off the skin.

  In addition, since the annular protrusions 32 are formed side by side in the axial direction, it is possible to always prevent the second piston 36 from rebounding (hold the second piston 36) at the optimum position. In addition, since three or more claws 34 are formed at equal intervals, the second piston 36 is not inclined within the holder 30 by evenly contacting the lower surface 32A of one annular projection 32. Therefore, the puncture depth of the microneedle 38 can be maintained in a stable state (uniformly), and administration of the drug solution can be promoted.

  Thus, when the microneedle 38 is punctured into the skin, the main body 12 including the temporary fixing member 20 is removed from the holder 30. The main body 12 including the temporary fixing member 20 removed from the holder 30 is replaced with the temporary fixing member 20 as needed, and then used for another holder 30.

  On the other hand, the holder 30 is kept attached to the arm until the administration of the drug solution from the microneedle 38 is completed. In addition, since the holder 30 and the second piston 36 are made transparent, it is possible to monitor the medical fluid administration situation of the microneedle 38.

  When administration of the drug solution from the microneedle 38 is completed, the holder 30 (holder 42) is removed from the arm. Then, the second piston 36 is pressed from the upper side, and the second piston 36 is taken out from the lower side of the holder 30. Thus, the second piston 36 removed from the holder 30 is discarded, and a new second piston 36 is inserted into the holder 30.

  The series of puncturing methods by the applicator 10 are as described above, but the applicator 10 according to the present embodiment is made of resin, so it is lightweight and has a cylindrical shape, so it achieves dimensional accuracy. There is an easy advantage. Further, since the biasing member is a coil spring 14, there is also an advantage that it is easy to adjust its biasing force (a spring constant, which is compression energy to be converted to puncture energy).

  As mentioned above, although the applicator 10 which concerns on this embodiment was demonstrated based on drawing, the applicator 10 which concerns on this embodiment is not limited to the thing of illustration, Within the range which does not deviate from the summary of this indication, The design can be changed as appropriate. For example, the larger the number of claws 34, the better, but as shown in FIG. 10, it is sufficient if at least three are formed at equal intervals.

  Further, the main body 12 is preferably formed in a cylindrical shape having an outer diameter that is easy to hold with fingers, but may be formed in, for example, a regular polygonal shape as long as the size is easy to hold with fingers. Moreover, you may form a hollow part (illustration omitted) etc. in the suitable position of the surrounding wall of the main body 12 so that holding | grip with a finger is easy. Furthermore, micro processing (knurling) may be performed on appropriate positions of the peripheral wall of the main body 12 so that the fingers do not slip easily.

  Further, the claw-like member 33 (the claw portion 34) is not limited to metal, and may be made of resin such as polypropylene (PP) or polyetheretherketone (PEEK). The biasing member provided inside the main body 12 is preferably a coil spring 14, but is not limited to the coil spring 14. For example, although not shown, a leaf spring or a disc spring may be used. Good.

DESCRIPTION OF SYMBOLS 10 Applicator 12 Main body 12A Intake / exhaust port 12B Intake / exhaust port 13 Female screw part 14 Coil spring (biasing member)
Reference Signs List 15 expanded diameter portion 15A claw portion 16 first piston 16A screw hole portion 18 lever member 18A male screw portion 19 operation portion 20 temporary fixing member 21 male screw portion 22 through hole 24 slit portion 26 groove portion 28 slope (inclined surface)
Reference Signs List 30 holder 31 groove portion 32 annular projection 32A lower surface 32B upper surface 33 claw-like member 34 claw portion (locking portion)
34A tip 35 base portion 35A through hole 36 second piston 36A large diameter portion 36B small diameter portion 37 convex portion 38 microneedle 39 percutaneous absorption sheet 40 regulating means 42 holding member 44 upper half 46 lower half 48 tape member θ1 angle θ2 angle φ tension Output D Interval S Gap

Claims (7)

With a cylindrical body,
A biasing member provided inside the body;
A first piston provided inside the main body and biased by the biasing member toward one axial end of the main body;
A lever member for pulling up the first piston to the other axial end of the main body against the biasing force of the biasing member;
A temporary stop member provided at the other axial end of the main body and temporarily holding the lever member in a state in which the first piston is pulled up;
A cylindrical holder provided detachably at one axial end of the main body;
A plurality of microneedles are attached to the surface facing the skin and provided inside the holder, and the temporary attachment of the lever member is released, and the biasing force of the biasing member pushes out the axial direction one end side A second piston which is ejected toward the skin by being pushed out by the first piston,
Restricting means provided inside the holder for restricting the movement of the second piston to the other axial end side after the second piston hits the skin;
Equipped with
The regulation means
At least three locking portions provided at equal intervals on the peripheral portion of the second piston;
A locked portion formed on an inner circumferential surface of the holder, the locking portion being in contact from a direction opposite to a direction in which the second piston is pushed out;
With an applicator. The locking portion is constituted by a claw portion at least the tip of which can be elastically deformed to the axial center side,
The applicator according to claim 1, wherein a plurality of the locked portions are formed side by side in the axial direction of the holder.   The peripheral wall of the main body is provided with an air intake / exhaust port for taking air into the inside of the main body as the first piston is pulled up and discharging the air inside the main body as the first piston is punched out. The applicator according to claim 1 or 2.   The biasing member is a coil spring, and when the free length of the coil spring is L1, the total length of the coil spring when contracted is L2, and the moving amount of the first piston is X, L1 <L2 + X is satisfied. An applicator according to any one of the preceding claims.   The applicator according to any one of claims 1 to 4, wherein the main body and the holder are formed in a cylindrical shape, and an enlarged diameter portion fitted to the holder is formed at one axial end of the main body. .   The applicator according to any one of claims 1 to 5, wherein the temporary fixing member is configured to be removable from the other axial end of the main body.   An end of the lever member on the pull-up direction side is an operation portion bent at a right angle to the axial direction of the main body, and a slit portion passing the operation portion is formed in a peripheral wall of the temporary fixing member, The groove part holding the said operation part and the inclined surface which guides the said operation part detached from the said groove part to the said slit part are formed in the end surface by the side of the said raising direction of the temporary fixing member. An applicator according to any one of the preceding claims.