JP2019084318A - Syringe warmer - Google Patents

Abstract

To provide a warming system dedicated to a small-sized syringe, capable of making a syringe itself perform warming for the purpose of viscosity reduction for impregnation of high-viscosity agent (contrast agent and its suspension liquid), requiring especially high pressure in hand-made impregnation of a narrow diameter syringe.SOLUTION: Warming elements are made by applying fine mesh-like pattern printing by conductivity particles (Ag or the like) to one surface of a thin film (PET or the like) which can softy correspond with sticking by winding around the periphery whole circumference of a narrow diameter syringe (Φ18 mm or less), and the warming elements are electrically connected by a pair of electrodes set at an interval, and are formed so as to generate planar heat evolution.SELECTED DRAWING: Figure 1

Description

Detailed Description of the Invention

The present invention relates to micro fluid injection under an X-ray environment in the medical field, and in particular, hepatic artery chemoembolization (TACE), endoscopic retrograde cholangiopancreatography (ERCP), cerebral aneurysm coil, The present invention relates to a heating system for a small syringe capable of reducing viscosity by heating a high viscosity drug (such as a contrast agent and an anticancer agent) used for microcatheter treatment such as embolization to a suitable temperature.

  Conventionally, a medical procedure has been practiced in which a catheter inserted percutaneously into a blood vessel is guided to an organ such as the brain or abdomen, and a therapeutic agent, an embolic agent, a contrast agent and the like are administered and injected. In recent years, medical advances have made it necessary to inject therapeutic agents, embolic agents, contrast agents and the like to smaller peripheral blood vessels, and research and development on improvement of functionality of microcatheters that can be inserted into these small peripheral blood vessels becomes active. ing.

In the research and development of these microcatheters, various maneuverability is required because it is necessary to reliably advance the winding thin peripheral blood vessels by the operation of the operator. This required function includes pushability that reliably transmits the pushing force of the operator to the tip of the microcatheter, and torque transmission that reliably transmits the rotational force applied by the operator to the tip of the microcatheter. , Guide wire followability inside a curved blood vessel along a guide wire passing through the lumen of the microcatheter, and kink resistance that does not cause the microcatheter to bend even at the bend or bend of the blood vessel. In order to realize these operability, forming a reinforcing layer having a braided structure or a coil structure is also performed in many microcatheters. (Refer to patent documents 1-3)

For this reason, the lumen of the microcatheter is only following a reduction in diameter (minimum inside diameter 0, 43 mm), and since the extension of the effective length (up to 2, 030 mm) is also progressing, in addition to the manual injection There are situations where burdens are increasingly imposed, problems such as the pressure and speed of injection can not be kept constant, and a clear image can not be obtained (blood vessel contrast is poor) or the drug can not be delivered to the target site ( Due to the fact that the treatment is not completed), the quality of medical care can not be improved.

However, almost no attempt has been made to solve or assist them, and the method by diversion heating of existing large-sized heating devices (water bath etc.) (see Non-Patent Document 1) or high amount The method of heating the connecting tube itself which connects the catheters directly from the drug solution container or the drug solution filling and injecting apparatus to continuous infusion of the above is the extent disclosed in the patent document disclosed in recent years. (Refer to patent documents 4-5)

JP 2008-295825 A JP, 2009-89814, A JP, 2014-113485, A JP, 2006-68264, A Unexamined-Japanese-Patent No. 2010-279698 New Drug and Linguistic Journal J. New Rem. & Clin. Vol 61 No 5 2012 Early-stage clinical effects of heated miriplatin-lipiodol

In any of these methods, there are problems in using these technologies, and Non-Patent Document 1 is a heating method that is advantageous for drug containers, and is a heavy equipment that involves transportation and complicated water injection operations for its use. In the other patent documents 1 and 2, the use of a liquid container directly or a high-volume continuous injection connecting a liquid-filled injection device and a catheter with an extension pipe is largely premised, so the condition is 10 cc or less There is no consideration for simple heating immediately before use with a small syringe directly, and it is not suitable particularly for microinjection.

Therefore, an object of the present invention is to provide a heating system based on a small-sized syringe which can be directly connected to a microcatheter and whose control of quantity, pressure and heat retention is easy.

The present inventor applies mesh pattern printing (100 μ level) with conductive particles (Ag etc.) to one surface of a low resistance type transparent film (PET etc.), and electrically generates heat in the form of a surface. It has been found that continuous and optimum heating can be achieved as a heater that can be used as a heating element to be produced and can flexibly correspond to winding and sticking around the entire circumference of a small diameter syringe, based on this, a heating system for small syringes The present invention has been completed.

That is, the small syringe heating injection system according to the present invention is minimized by the combination configuration of the small syringe and the thin transparent film heater, and the direct connection to the microcatheter is made possible, and the convenience of manual pressure injection remains as it is. Further, the present invention provides a heating system for a small syringe, characterized in that it works to reduce the injection pressure.

In addition, it is preferable that electrical connection to the thin transparent film heater described above can be conducted more easily and safely, and it is even more preferable that the arrangement can be performed so as not to interfere with the treatment operation.

It is preferable that the flexibility of the thin transparent film heater described above can be carried out without causing cracking or bending even when wound and attached to a 10 cc syringe (Φ 18), and further, when wound and attached to a minimum 1 cc syringe (Φ 9) It is even more preferable that the same can be easily performed.

It is preferable that the confirmation of the heating state of the thin transparent film heater described above can be performed in a form that does not hinder the injection operation, and it is further more preferable that a complicated electrical circuit is unnecessary and easy to perform.

The operation of the first problem solving means is as follows.
The electrical connection to the thin transparent film heater is designed at 3 V, which enables use with 1.5 V dry cell multipliers (two), thus providing flexibility in any place of use. Can exert a synergetic effect of working on safety without excessive heating above tolerance.

The operation of the second problem solving means is as follows.
The flexibility of the thin transparent film heater simplifies the protection (pasting of the film) on the printing surface by application of a solvent instead of the conventional process, and reduces the thickness by half. (0, 1 mm or less), can easily cope with winding on a minimum syringe Φ 9 mm, and can exhibit an optimum elasticity without causing cracking or bending.

The operation of the third problem solving means is as follows.
By providing a reversible liquid crystal temperature seal (26 to 46 ° C range) on the top of which confirmation of the heating state of the thin transparent film heater is set, the accuracy of ± 0.5 ° C, which made the power supply unnecessary In addition to facilitating the confirmation of the small syringe outer peripheral temperature in the above, it is possible to exert a synergetic effect of acting on the optimality that does not affect the injection operation.

By using the small syringe heating injection system of the present invention, it is possible to perform a simple operation and a small amount of injection aiming to reduce excessive high pressure injection at the time of injection. That is, the present invention does not require any significant development of a control device, etc., and relates to the development as an accessory based on the existing small-sized syringe, because it works for depressurizing microinjection simply and effectively while making use of portable characteristics. It is extremely advantageous for the use site of the microcatheter. Furthermore, the effect obtained by the method of the present invention is particularly advantageous in that it contributes to the improvement of the therapeutic effect on anticancer drug treatment, the reduction of complications, the improvement of the completion rate of treatment and the improvement of the patient's QOL.

In addition, the heating system for small syringes of the present invention relates to the social problem of the treatment refugees for cancer treatment in recent years, and as a countermeasure, the embolization treatment (the embolic material is sent from the microcatheter The possibility of using it for cutting off the nutritional source of cancer is increasing, and the simple structure makes it relatively easy to make, and all preparation for its use (water bath loading and water injection) If work is not required, it can be used well from the viewpoint of hygiene, and there is no problem in terms of safety (it seems that there is no overheating above the allowable voltage with dry cell application), etc. The expectation of is great.

It is a block diagram which shows embodiment in the heating system (100) for small syringes of this invention. It is an enlarged block diagram of the ultra-thin transparent film heater (10b), the heat source cord with a connector (10c), and the battery box with switch (10d) used in the small syringe heating system (100) of FIG. It is a graph which shows the exothermic temperature deviation duration time in 3V application (2 AA batteries) in heating experiment. It is a graph which shows the correlation with the temperature in a syringe and the external temperature by a liquid-crystal temperature seal in heating experiment.

The small syringe heating system (100) capable of achieving the effects as described above is used for winding and sticking (10b) around the entire periphery of the small syringe (10a) as shown in the configuration diagram of FIG. , And is electrically connected by the connector-equipped heat source cord (10c) and the switch-equipped battery BOX (10d) to start heating thereof.

Hereinafter, the heating system (100) for a small syringe according to the embodiment of the present invention will be described in detail with reference to FIGS.

Fig. 1 shows the entire assembly configuration of the small syringe heating system (100), with 10a showing the small syringe unit, 10b showing the ultra thin transparent film heater unit, and 10c and 10d with the connector used by connecting to 10b A heat source cord part and a battery BOX part with a switch are shown.

10b of FIG. 2 is an enlarged plan view of an ultrathin transparent film heater portion (10b), 10b1 is an ultrathin transparent film, 10b2 is an electrode, 10b3 is a mesh-like heating element, 10b4 is a heat source connection terminal, 10b5 Indicates a liquid crystal temperature seal.

10R1 in FIG. 2 is a front view of the flat ultra thin transparent film heater of 10b rolled into a roll, and 10b1 is an ultrathin transparent film, 10b4 is a heat source connection terminal, 10b5 is a liquid crystal temperature seal, and 10b6 is The adhesive attachment part is shown.

10R2 in FIG. 2 is a side surface of the flat ultra thin transparent film heater of 10b rolled into a roll, 10b1 is an ultrathin transparent film, 10b4 is a heat source connection terminal, 10b5 is a liquid crystal temperature seal, and 10bc1 is The heat source cord with connector is shown.

In the enlarged configuration of the battery box with switch 10d in FIG. 2, 10d1 is a AA battery × 2 box, 10d2 is an ON-OFF switching switch, 10d3 is a cover for battery box with switch, and 10c1 is with connector The heat source code is shown.

FIG. 3 shows transition of the temperature state at the time of attachment heating to the small-sized syringe (10a), T1 shows the elapsed temperature in the small-sized syringe, and T2 shows the elapsed temperature of the environment.

The usage method of the heating system (100) for small syringes which has such a function is demonstrated with reference to FIGS. 1-2.

First, the planar ultra thin transparent film heater (10b) of FIG. 2 is wound around a small-sized syringe (10a) to form the shape of FIG.

Next, connect the heat source cord with connector (10c1) to the heat source connection terminal (10b4) to make it as shown in Fig. 1 and then operate the ON-OFF switching switch (10d2) of the battery box with switch (10d) to heat Start it.

The heating system (100) for small syringes described above and illustrated in the drawings is not limited thereto, and various modifications or additions can be made to various forms or sizes based on the spirit of the present invention. These are not excluded from the scope of the present invention.

Basic experiment example

Hereinafter, basic experimental examples regarding the heating function of the small syringe heating system (100) of the present invention will be described in detail with reference to FIGS. 3 and 4. FIG.

In FIG. 3, water adjusted to about 25 ° C. was placed in a small-sized syringe (10 ml), and ultra thin thin film-heater was wound and attached, and two types of temperature transitions were compared: one with and one without.

In Fig. 3, water adjusted to about 25 ° C was put into a small syringe (10 ml) on which a thin and thin transparent film-heater was wound and mounted, and heating (3 V applied by 2 AA batteries) was started The temperature transition was measured together with the environmental temperature.
As equipment used, Sato Corporation 3 channel thermometer data logger MTM-380SDJ, wire temperature sensor TP-300 for measuring environmental temperature, sheath type temperature sensor TL-32K for measuring temperature in the syringe (sensor tip We use two with 3.8 3.8 mm × length 120 mm).
"result"
It can be seen that heating at 37 ° C. to 45 ° C. is continued for 5 hours under an environmental temperature of 26 to 27 ° C.

In Fig. 4, water adjusted to about 25 ° C was put into a small syringe (10 ml) on which a thin and thin transparent film-heater was wound and mounted, and heating (3 V applied by 2 AA batteries) was started The temperature transition was compared and measured together with the small syringe outer surface temperature by the liquid crystal temperature seal.
As equipment used, Sato Corporation 3 channel thermometer data logger MTM-380SDJ, sheath type temperature sensor TL-32K (sensor tip part φ 3.8 mm × length 120 mm) for measuring temperature in the syringe, and syringe outer surface temperature measurement Use two kinds of reversible liquid crystal temperature seal N-26-46D from Asei Kogyo Co., Ltd. for the purpose.
"result"
It can be seen that the difference in heating at 37 ° C. to 45 ° C., which is the target heating temperature of the present invention, remains within 1 ° C.

100 Embodiment configuration diagram of heating system for small-sized syringe 10a Small-sized syringe 10b planar ultra thin transparent film heater
10b1 Ultra-Thin Transparent Film 10b2 Electrode 10b3 Mesh-like Heating Element 10b4 Heat Source Connection Terminal 10b5 Flat Ultra-Thin Transparent Film Heater of Liquid Crystal Temperature Seal 10R1 10b Rolled in Front of Front 10b6 Adhesive Bonding Part 10R2 10b Side 10c1 connector with heat source cord 10d with switch heat source cord in the state where the ultra thin transparent film heater is rolled into a roll shape
10d1 AA battery × 2 BOX
10d2 ON-OFF switching switch
10d3 Cover for battery BOX with switch T1 Heating temperature T2 Environment temperature

100 shows the whole assembly of the embodiment of the present invention, in which 10a shows a small syringe, 10b shows an ultra thin transparent film heater, and 10c shows a power supply BOX with a connector. It is a block diagram which shows the detail of the ultra-thin transparent film heater (10b) in the heating systems (100) for small syringes of FIG. It is a block diagram which shows the detail of battery BOX with a connection connector (10c) in the heating system (100) for small syringes of FIG. It is a graph which shows the exothermic temperature and duration in 3V application (2 AA batteries) in heating experiment. It is a graph which shows the correlation with the temperature in a syringe and the external temperature by a liquid-crystal temperature seal in heating experiment.

The small syringe heating system (100) capable of achieving the effects as described above is, as shown in the overall assembly view of FIG. 1, wound and stuck in the shape of 10b around the entire periphery of the small syringe (10a) , And is electrically connected by the power supply box with a connection connector (10c) to start its heating.

Fig. 1 shows the assembled configuration of the entire heating system (100) for a small syringe, 10a shows a small syringe part, 10b shows an ultra thin transparent film heater part, and 10c shows a battery box part with connector connected to 10b. Indicates

10b of FIG. 2 is a detailed plan view of an ultrathin transparent film heater part, where 10b1 is an ultrathin transparent film, 10b2 is an electrode, 10b3 is a mesh heating element, 10b4 is a heat source connection terminal, and 10b5 is a liquid crystal temperature 10R1 shows a seal, and 10R1 shows the front of the flat ultra thin transparent film heater of 10b rolled into a roll, and 10R2 shows a side rolled back into a roll. In addition, 10b6 in 10R1 shows an adhesive bonding part.

10c in FIG. 3 is a detailed plan view of the battery box with a connection connector, 10d1 is a AA battery × 2 box, 10d2 is an ON-OFF switching switch, 10d3 is a cover for the battery box with switch, 10c1 is The heat source cord with connector is shown.

FIG. 4 shows the transition of the temperature state at the time of attachment and heating to the small syringe (10a), T1 indicates the elapsed temperature in the small syringe, and T2 indicates the elapsed temperature of the environment.

The usage method of the heating system (100) for small syringes which has such a function is demonstrated with reference to FIGS. 1-3.

First, the planar ultra thin transparent film heater (10b) of FIG. 2 is wound around a small-sized syringe (10a) to form the shape of FIG.

Next, the connection connector (10c1) is connected to the heat source connection terminal (10b4) to make it as shown in FIG. 1, and then the ON / OFF switching switch (10c2) of the battery BOX is operated to start heating.

The heating system (100) for small syringes described above and illustrated in the drawings is not limited thereto, and various modifications or additions can be made to various forms or sizes based on the spirit of the present invention. These are not excluded from the scope of the present invention.

Hereinafter, basic experimental examples regarding the heating function of the small syringe heating system (100) according to the present invention will be described in detail with reference to FIGS.

In FIG. 4, water adjusted to about 25 ° C. was placed in a small-sized syringe (10 ml), and ultra thin thin film-heater was wound and attached, and two types of temperature changes were compared between one that was not attached and one attached.

In Fig. 5, water adjusted to about 25 ° C was put into a small syringe (10 ml) on which a thin and thin transparent film-heater was wound and mounted, and heating (3 V applied by 2 AA batteries) was started The temperature transition was measured together with the environmental temperature.
As equipment used, Sato Corporation 3 channel thermometer data logger MTM-380SDJ, wire temperature sensor TP-300 for measuring environmental temperature, sheath type temperature sensor TL-32K for measuring temperature in the syringe (sensor tip We use two with 3.8 3.8mm x 120mm in length).
"result"
It can be seen that heating at 37 ° C. to 45 ° C. is continued for 5 hours under an environmental temperature of 26 to 27 ° C.

100 Whole assembly drawing of embodiment of heating system for small size syringes 10a small size syringes 10b planar ultra thin transparent film heater
10b1 Ultra-Thin Transparent Film 10b2 Electrode 10b3 Mesh-like Heating Element 10b4 Heat Source Connection Terminal 10b5 Flat Ultra-Thin Transparent Film Heater of Liquid Crystal Temperature Seal 10R1 10b Roll-Shaped Front 10b6 Adhesive Bonding Section 10R2 10b Power supply BOX with side 10c connector with the ultra thin transparent film heater rolled into a roll
10c1 connection connector 10c1 AA battery × 2 BOX
10c2 ON-OFF switching switch
10c3 Cover for battery BOX with switch T1 Heating temperature T2 Environment temperature

Claims (6)

Applying mesh-like pattern printing with conductive particles (Ag, etc.) on one side of a thin film (PET, etc.) that can flexibly correspond to winding and sticking around the entire circumference of a small diameter syringe (Φ 18 mm or less) The heating element is electrically connected by a pair of electrodes set at intervals and generates heat in the form of a sheet,
Small syringe heating system. The mesh pattern printing on the thin film is performed with a fine line of about 100 μm to the transparent film, thereby maintaining the transparency that does not hinder the confirmation of the remaining amount in the syringe. And
Small syringe heating system. The flexibility of the thin film simplifies the protection (pasting of the film) on the printing surface by application of a solvent instead of the conventional process, and reduces the thickness by half. (1 mm or less), easily adaptable to winding on a minimum syringe Φ 9 mm, and characterized by having an optimum elasticity which does not cause cracking or bending.
Small syringe heating system. The heat output of the heating element is characterized in that mesh printing is performed in a design capable of generating planar heat generation of 37 to 45 ° C. under an environment of room temperature 24 to 27 ° C. under application of 3 V. ,
Small syringe heating system. The electrical connection to the heating element is designed at 3 V, which allows the use of 1.5 V dry cell multipliers (two), thus providing flexibility in any place of use, Characterized by having safety without excessive heating above tolerance.
Small syringe heating system. The heating element portion of the thin film has a reversible liquid crystal temperature seal (26 to 46 ° C. range) set to be attached on the upper surface thereof, and confirmation of the small diameter syringe outer peripheral temperature with an accuracy of ± 0.5 ° C. It is characterized by facilitating and contributing to safer heating,
Small syringe heating system.