JP2019069087A - Ophthalmologic liquid medicine administration device and liquid medicine administration member - Google Patents

Abstract

To provide an ophthalmologic liquid medicine administration device and a liquid medicine administration member capable of administering eye drops without a user looking up, which allow even an elderly person, a patient suffering from rheumatism, and a patient with poor grip strength to administer a predetermined very small amount of liquid medicine to the surface of an eyeball easily.SOLUTION: An ophthalmologic liquid medicine administration device includes a pressurized storage space 25 where liquid medicine 100 is stored, a liquid medicine discharge port 20 for discharging the liquid medicine 100 from the storage space 25, a lid part 22 for closing the liquid medicine discharge port 20, and a drive part 23 for opening/closing the lid part 22. When the drive part 23 is driven and the lid part 22 is brought into an open state, the liquid medicine 100 in the storage space 25 is discharged from the liquid medicine discharge port 20.SELECTED DRAWING: Figure 4

Description

  The present invention relates to an ophthalmic drug solution dispenser and a drug solution dispensing member, and relates to an ophthalmic drug solution dispenser and a drug solution dispensing member that composes an ophthalmic drug solution dispenser that dispenses a small amount of drug solution to the eye of a patient.

  In recent years, with the aging of patients, there are an increasing number of patients who are unable to instill eyedrops facing up to drop eye drops and who can not correctly drop a drug solution on the surface of the eye. In addition, in the case of a rheumatoid patient or a patient having a poor grip, the eye drop container may not be pressed by itself or the eye drop container may not be opened.

  In addition, eye drops that can be held on the surface of the eye are considered to be only about 7 μL at maximum. Therefore, if 25 to 50 μL of eye drops are conventionally administered dropwise, excessive eye drops necessarily flow out of the eye and not only can the medicine be effectively used but also be absorbed by the surrounding tissues of the eye And there are concerns about side effects associated with the transition to the entire body.

Therefore, a spectacle-type ophthalmologic apparatus (Patent Document 1, Patent Document 2) for administering a drug to the eye and a handy-type spray apparatus (Patent Document 3) for spraying a drug solution in the form of mist in the state facing the front have been proposed. There is.
In patent document 1, the dispenser of a thermal inkjet system is employ | adopted as liquid injection means (refer FIG. 5 of patent document 1, FIG. 6).
In Patent Document 2, a piezo jet dispenser or a thermal inkjet dispenser is employed.
Patent Document 3 discloses an apparatus that includes an ejector mechanism that generates a droplet flow, and sprays 20 (about 4 pL) to 400 microns (about 33 nL) of chemical solution in the form of a mist through countless openings.

WO 1994/003135 JP, 2005-21701, A JP-A-2015-506731

However, the flying distance of the drug solution by the thermal ink jet method or the piezo jet method as in Patent Documents 1 and 2 is about several millimeters in the horizontal direction, and there is also a problem that the drug solution becomes misty and disperses around the eye. Therefore, accurate eye drops can not always be achieved, and has not been put into practical use (see FIG. 7 of Patent Document 1 and FIG. 1 of Patent Document 2).
Moreover, since patent document 3 is sprayed in the form of a mist, the drug solution is administered not only to the surface of the eye but also to the entire surrounding tissue, so the availability of eye drops (bioavailability) inevitably decreases, and further There are also concerns about side effects and the like on surrounding tissues of the eye (see FIG. 1C-2 and FIG. 4 in Patent Document 3).

In addition, current eyedrops are mainly aqueous solutions, and in addition to preservatives, various additives such as stabilizers, buffers, tonicity agents and the like are blended. Therefore, their safety is questioned, and it is an issue to reduce additives.
For example, the problem is to reduce the amount of preservative to be formulated to prevent secondary contamination after opening the eye drop container, to search for a safer preservative, or to use no preservative. Attempts have been made to develop preservative free containers.
However, the situation has not yet been satisfied for the patients. Furthermore, the bioavailability of current eyedrops is generally less than 1%, and the topical or systemic side effects of excessive drugs cause problems.
In the case of instillation administration of eye drops from the existing eye drop container, in the case of multi-administration, there is a concern that the drug may be washed out later. Therefore, compliance with medications, such as interval of administration, must be enforced. In addition, there is a disadvantage that a doctor or a pharmacist can not manage medication.

  Therefore, according to the present invention, it is possible to administer eye drops without looking upwards, and an ophthalmic solution capable of easily administering a predetermined amount of a small amount of drug solution to the surface of the eye even in elderly people, rheumatoid patients, and patients with poor grip. It aims at providing an administration device and a medical fluid administration member.

  Invention of Claim 1 for solving the above-mentioned subject has a medical fluid administration member in a case, and the medical fluid administration member stores a medical fluid and is pressurized from storage space, and from the storage space The chemical solution discharge port for discharging a chemical solution, a lid portion for closing the chemical solution outlet port, and a drive unit for opening and closing the lid portion, driving the drive unit to open the lid portion, the chemical solution An ophthalmic drug administration device characterized by discharging a drug solution in the storage space from a discharge port.

  The invention described in claim 2 is the ophthalmic medical solution administration device according to claim 1, which has pressurizing means, and the storage space is pressurized by the pressurizing means.

  The invention according to claim 3 is the ophthalmic liquid medicine administration device according to claim 1 or 2, characterized in that the casing portion is provided with a discharge button which is driven by the drive portion when pressed.

  The invention according to claim 4 includes a fixing jig for fixing the distance of the chemical solution discharge port to the eye peripheral portion, and the fixing jig is connected to the housing unit. It is an ophthalmic drug solution dispenser according to any one of claims 1 to 3.

  The invention as set forth in claim 5 is the ophthalmic liquid medicine administration device according to claim 4, wherein at least one of the casing and the fixing jig is transparent or translucent.

  The invention as set forth in claim 6 is characterized in that the drug solution administration member is provided with 1 or more and 10 or less of the drug solution discharge ports, and the ophthalmic drug solution administration device according to any one of claims 1 to 5 It is.

  The invention according to claim 7 is characterized in that the discharge amount of the chemical solution from the chemical solution discharge port when driving the drive unit and opening the lid is 1 nL or more and 7000 nL or less. It is an ophthalmic drug solution administration device as described in any one of -6.

  The invention as set forth in claim 8 is characterized in that the drug solution administration member is attachable to and detachable from the housing unit, and the ophthalmic drug solution administration device according to any one of claims 1 to 7. is there.

  The invention according to claim 9 is a chemical solution administration member which is detachably mounted in a housing portion, which is a storage space for storing and pressurizing a chemical solution, a chemical solution discharge port for discharging a chemical solution from the storage space, and The chemical solution discharge port has a lid portion for closing the chemical solution discharge port, and a drive portion for opening and closing the lid portion, and the chemical solution discharge port in the storage space is driven by driving the drive portion to open the lid portion. It is a chemical | medical solution administration member characterized by discharging from.

  According to the ophthalmic drug solution dispenser and drug solution dispensing member of the present invention, it is possible to administer eye drops without looking upwards, and even in the elderly, rheumatoid patients, and patients with poor grip ability, it is easy to obtain a predetermined amount The drug solution can be administered to the surface of the eye.

BRIEF DESCRIPTION OF THE DRAWINGS It is a perspective view which shows the general use condition of the ophthalmic drug solution administration device of the first embodiment of the present invention, and it is partially transmitted to show only the main part. It is the perspective view which showed notionally the ophthalmic drug administration device of FIG. 1, and it is made to permeate partially and only the principal part is illustrated. It is a disassembled perspective view of the ophthalmic drug solution dispenser of FIG. It is a disassembled perspective view of the main-body part of FIG. It is sectional drawing of the chemical | medical solution administration member of FIG. 4, (a) shows a closed state, (b) shows an open state. It is a front view of the ophthalmic drug administration device of FIG. FIG. 10 is a perspective view conceptually showing an ophthalmic drug solution administration device according to another embodiment of the present invention, in which only a main part is shown by partially transmitting. It is a figure which shows the pattern of the chemical | medical solution discharge port of this invention, (a) is a case where one chemical | medical solution discharge port is provided, (b) is a case where five chemical | medical solution discharge ports are provided. FIG. 7 is a cross-sectional view of an ophthalmic drug solution dispenser according to another embodiment of the present invention.

  Hereinafter, embodiments of the present invention will be described in detail. In the following description, the posture of FIG. 1 is used as a reference, and the eye peripheral part 200 side of a patient is referred to as the front side, and the distal side as viewed from the patient is the rear side, unless otherwise noted.

The ophthalmic drug solution administration device 1 according to the first embodiment of the present invention includes a drug solution outlet 20 as shown in FIG. 1, and delivers the drug solution 100 from the drug solution outlet 20 to the surface of the eye 201 of a patient. The ophthalmic drug solution dispenser 1 can discharge the drug solution 100 in the horizontal direction from the drug solution outlet 20 in a horizontal posture in which the drug solution outlet 20 faces the horizontal direction, and the patient does not go upward, that is, One of the features is that the drug solution 100 can be administered regardless of the posture of the patient.
Hereinafter, the ophthalmic drug solution administration device 1 will be described in detail based on these characteristics.

As shown in FIG. 3 and FIG. 4, the ophthalmic drug solution administration device 1 includes a main body 2 and a fixing jig 3 that is detachable from the main body 2.
As shown in FIG. 4, the main body 2 includes a housing 10, a drug solution administration member 11, a power switch 12, a discharge button 15, and a battery 16.

The housing unit 10 is a member that constitutes the outer shell of the ophthalmic drug solution administration device 1.
The housing portion 10 is a hollow cylindrical body having an opening 18 on the front side and a closed rear side, and is capable of housing the drug solution administration member 11 therein.
The chemical solution administration member 11 is a cartridge type chemical solution administration member, which is detachable from the housing unit 10, and can be replaced with a new chemical solution administration member 11 after use.
In addition, the connection method with respect to the housing | casing part 10 of the chemical | medical solution administration member 11 is not specifically limited. For example, screwing may be provided in each of the drug solution administering member 11 and the housing unit 10 to provide a screwing portion, and connection may be made by screwing, or fitting portions are provided in each of the drug solution administering member 11 and the housing unit 10 , And may be connected by fitting. Moreover, you may connect by magnetic force with a magnet etc., and you may connect with temporary fastening elements, such as a screw.

As shown in FIG. 5, the drug solution administration member 11 includes a drug solution storage unit 21 having a drug solution outlet 20, a lid 22 for closing the drug solution outlet 20, and a drive unit 23 for opening and closing the lid 22. By driving the drive unit 23, the lid 22 closing the chemical solution discharge port 20 is opened and closed, and the chemical solution 100 in the chemical solution storage unit 21 is discharged from the chemical solution discharge port 20.
The chemical solution administration member 11 of the present embodiment is an electromagnetic valve jet system, and adjusts the pressure of the chemical solution 100, the viscosity of the chemical solution 100, and the diameter of the chemical solution outlet 20 to adjust a small amount of liquid (for example, several nL to several μL) The drops can be discharged about 8 cm in the horizontal direction. The drug solution administration member 11 can administer a small amount of drug solution 100 in the form of droplets onto the surface of the eye 201 of a patient.

As shown in FIG. 5, the drug solution administration member 11 of the present embodiment includes a drug solution storage unit 21 and a drive unit 23.
The drug solution storage unit 21 has a storage space 25 inside, and can store the drug solution 100 in the storage space 25. The chemical solution storage unit 21 incorporates a pressure application unit 26 (pressurizing means), and includes a chemical solution discharge port 20 on the wall surface on the front end side. The chemical solution storage unit 21 can be pressurized as needed when filling the chemical solution.

The drug solution discharge port 20 is a communication hole that communicates the storage space 25 of the drug solution storage unit 21 with the outside, and is a drug solution passage hole through which the drug solution 100 passes during dosing.
The opening shape of the drug solution outlet 20 is preferably circular or polygonal.

The pressure application unit 26 is not particularly limited as long as the chemical solution 100 in the chemical solution storage unit 21 can be pressurized.
The pressure application unit 26 of the present embodiment is configured of a pressure spring 27 and a wall surface forming unit 28 that constitutes a part of the inner wall of the storage space 25.

The drive part 23 is a part which opens and closes the cover part 22 instantaneously, is provided with at least the coil part 30 and the core part 31, and is a part which changes electrical energy into mechanical motion.
The coil portion 30 is a known coil, and is a member that generates a magnetic field by being energized and moves the core portion 31.
The core portion 31 is a rod-like member, and the lid portion 22 is connected to the front end portion thereof.
The lid 22 is a lid that opens and closes the opening of the chemical solution outlet 20.

The power switch 12 is a switch that switches the electrical connection between the battery 16 and the drive unit 23 between the connected state and the disconnected state.
For example, when the power switch 12 is pressed, the battery 16 and the drive unit 23 are electrically connected, and when the power switch 12 is pressed again, the electrical connection between the battery 16 and the drive unit 23 is cut off. The power switch 12 may be a slide switch.

The discharge button 15 is a button for electrically connecting the battery 16 and the drive unit 23.
For example, by pressing the discharge button 15 with the power switch 12 turned on, the drive unit 23 is energized to be driven, and the chemical solution 100 in the chemical solution storage unit 21 can be discharged from the chemical solution discharge port 20. Become.

  The battery 16 is a power source for driving the drive unit 23.

The fixing jig 3 is a member that fixes the positional relationship between the patient's eye 201 and the drug solution outlet 20 of the main body 2 by pressing the fixing jig 3 against the eye peripheral portion 200 of the patient.
As the fixing jig 3 can be read from FIG. 3, when the cross-sectional shape is an annular shape, it is desirable that the fixing jig 3 be a member having a truncated cone shape in appearance. The fixing jig 3 has a vertex side on the rear end side (casing 10 side), and has a diameter slightly expanding from the rear end side to the tip side (eye peripheral portion 200 side of the patient).

The rear end portion of the fixing jig 3 is attachable to and detachable from the housing unit 10.
In addition, the connection method with respect to the housing | casing part 10 of the fixing jig 3 is not specifically limited. For example, screwing may be provided in each of the fixing jig 3 and the housing 10 to provide a screwing part, and connection may be performed by screwing, or fitting parts may be provided in each of the fixing jig 3 and the housing 10 , And may be connected by fitting. Moreover, you may connect by magnetic force with a magnet etc., and you may connect with temporary fastening elements, such as a screw.

The material of the fixing jig 3 is preferably made of a material that is relatively soft and has transparency enough to allow the chemical solution discharge port 20 to be visible. For example, silicon and soft plastic can be used as the material of the fixing jig 3.
Since the material of the fixing jig 3 is made of a relatively soft material, when the patient lightly presses the ophthalmic drug solution applicator 1 against the eye peripheral area 200, the ophthalmic drug solution administration apparatus 1 for the eye peripheral area 200 Can improve the fixation of the
Further, by making the fixing jig 3 transparent or translucent, light is transmitted from the outside and the chemical solution discharge port 20 is illuminated, so that it can be visually recognized.

  Subsequently, the positional relationship of each component of the ophthalmic drug solution dispenser 1 will be described.

As shown in FIG. 2, the front end portion of the housing portion 10 of the main body portion 2 is connected to the fixing jig 3, the power switch 12 is disposed on the rear end surface, and the discharge button 15 is disposed on the side surface There is.
The drug solution dispensing member 11 is disposed in the housing 10 such that the drug solution outlet 20 is located on the front end side. The chemical solution administration member 11 is disposed at the center of the opening 18 of the housing 10 when the chemical solution outlet 20 is viewed from the front as shown in FIG. Is located.
The power switch 12 is provided on the outer surface of the housing 10, and in the present embodiment, is provided on the rear end face of the housing 10 as shown in FIG.
The discharge button 15 is provided on the outer surface of the housing unit 10, and in the present embodiment, is provided on the outer peripheral surface of the housing unit 10.
The battery 16 is disposed inside the housing unit 10.

  Subsequently, a drug solution 100 that can be suitably used in the ophthalmic drug solution dispenser 1 will be described.

The drug solution 100 used in the ophthalmic drug solution dispenser 1 may be an aqueous solution or an oil solution containing a drug, in consideration of the solubility, viscosity and the like of the drug.
Alternatively, the drug solution 100 may be an aqueous or oily suspension or emulsion containing a drug, and the drug solution 100 may be used by filling the storage space 25 of the drug solution storage unit 21.
It will not specifically limit, if it is a liquid which can be used as a base of the chemical | medical solution 100 in the temperature range from a cold place to room temperature. The solvent includes, for example, water, ethyl alcohol, ethylene glycol, polyethylene glycols, propylene glycol, glycerin, vegetable oil, animal oil, mineral oil, medium-chain fatty acid triglyceride and the like, and mixtures thereof.

The drug solution 100 is not particularly limited as long as it is used as an ophthalmic drug.
The drug solution 100 includes, for example, anti-inflammatory agents such as dipotassium glycyrrhizinate, epsilon aminocaproic acid, allantoin, berberine chloride, berberine sulfate, diphenhydramine hydrochloride, antihistamine agents such as chlorpheniramine maleate, flavin adenine dinucleotide sodium, cyanocobalamin, retinols Corneal therapeutic agents such as pyridoxine hydrochloride, panthenol, sodium pantothenate and sodium chondroitin sulfate, epinephrine, ephedrine hydrochloride, tetrahydrozoline hydrochloride, naphazoline hydrochloride, nafazoline hydrochloride, phenylephrine hydrochloride, hypoglycemic agent such as dl-methylephedrine hydrochloride, , Gatifloxacin, gentamicin, sulfamethoxazole, sulfisoxazole, and other antibacterial agents, Β-Lactam antibiotics such as lexine, imipenem, meropenem, antifungal agents such as amphotericin B, ketoconazole, fluconazole etc, refreshing agents such as menthol, borneol, camphor etc, timolol maleate, pilocarpine hydrochloride, carteolol, latanoprost, tafluprost Drugs for treating glaucoma and hypertension such as travoprost and ripasil, drugs for treating cataract such as facolidine, glutathione, pyrenoxine, sodium sodium pentacetyl sulfonate, antibiotics such as chloramphenicol, colistin, erythromycin, rapamycin, tacrolimus, cyclosporin Immunosuppressants such as hydrocortisone acetate, prednisolone acetate, dexamethasone, triamcinolone acetonide, corticosteroids such as fluorometholone, brinzolamide Carbonic anhydrase inhibitors such as dorzolamide, metazolamide, α2 blockers such as brimonidine, α1 blockers such as bunazosin, tocopherols, antioxidants such as vitamin C, hyaluronic acid, chondroitin sulfate, gefarnate, vitamin U, rebamipide etc And a local anesthetic such as lidocaine hydrochloride and dibucaine hydrochloride, and a test drug such as fluorescein, rose bengal, cyclopentolate and tropicamide.

Although the viscosity of the chemical | medical solution 100 is not specifically limited, It is preferable that it is 10000 cps or less, More preferably, it is 1000 cps or less, More preferably, it is 300 cps or less.
In the case of the high-viscosity drug solution 100, it may not be possible to achieve the flight distance necessary for the drug solution 100 to reach the surface of the eye 201 of the patient.

  Then, the general process assumed when a patient administers to the surface of the eyeball 201 using the ophthalmic drug administration device 1 will be described. The ophthalmic drug solution dispenser 1 can take any posture, and can deliver the drug solution 100 from any direction such as upward, downward, sideways, etc., but in order to facilitate understanding of the features of the present invention, The case where the chemical solution 100 can be discharged horizontally will be described.

First, the patient picks up the ophthalmic drug solution administration device 1 and presses the power switch 12 to turn it on and lightly presses the fixing jig 3 against the patient's eye peripheral part 200 while the patient's eye 201 and drug solution spit Position adjustment of the chemical solution outlet 20 is performed so that the outlet 20 faces the outlet.
That is, when the patient gently presses the fixing jig 3 against the eye peripheral portion 200, the drug solution outlet 20 can be seen, so that the drug solution injector 1 is appropriately moved so that the drug solution outlet 20 can be seen straight ahead. Make adjustments.

  At this time, the distance (the shortest distance) between the surface of the eye 201 and the drug solution discharge port 20 of the drug solution administration member 11 is not particularly limited, but for example, 1 cm or more and 8 cm or less, preferably 1.2 cm or more and 6 cm or less . If the distance between the surface of the eye 201 and the drug solution outlet 20 is less than 1 cm, the drug solution outlet 20 may come in contact with the surface of the eye 201 when using the drug solution administration device 1 for eye surgery. The fixed amount of drug solution 100 may not reach the surface of the eyeball 201.

  When the position adjustment is completed, the patient maintains the eye-opened state and depresses the discharge button 15, and a small amount of droplets are administered from the drug solution discharge port 20 of the drug solution administration member 11 to the surface of the eyeball 201.

At this time, it is preferable that the liquid amount (discharge amount) discharged from the drug solution discharge port 20 of the drug solution administration member 11 in one drug solution administration is 1 nL or more and 7000 nL or less, and more preferably 30 nL or more and 5000 nL or less .
If the liquid quantity is less than 1 nL, it will be difficult to reach the surface of the eye 201 of the patient, and if the liquid quantity is more than 7000 nL, it will flow out of the eye and the drug solution 100 will be wasted is there.
The amount of droplets of the chemical solution 100 can be adjusted by the diameter of the chemical solution outlet 20, the pressure of the chemical solution 100, and the opening and closing of the lid 22, but by providing a plurality of (for example, 2 to 10) chemical solution outlets 20. Can also be adjusted.

  Thereafter, the same operation is performed on one eye as necessary, and when the administration of the drug solution 100 is completed, the power switch 12 is pressed to turn off.

  When an artificial tear fluid is administered as a drug solution 100 as a drug solution 100 with a small amount of droplets of about 2000 nl onto the surface of the eye 201 using the above-described ophthalmic drug solution administration device 1 of the first embodiment, the drug solution 100 flows out of the eye In addition, the user (patient) did not feel irritation in the eye 201 and the peripheral area 200, and did not feel discomfort.

According to the ophthalmic drug solution administration device 1 of the present invention, since the drug solution 100 is discharged electrically from the drug solution outlet 20, there is no need for the patient to face upward, and the drug solution 100 can be delivered from any direction without relying on gravity. . Therefore, even for elderly people, rheumatoid patients, and patients with poor grip ability, a predetermined amount of a small amount of drug solution 100 can be accurately administered to the surface of the patient's eye 201, thereby improving patient convenience and excess drug solution 100. It is possible to prevent administration and reduce side effects caused by additives such as preservatives.
In addition, according to the ophthalmic drug solution dispenser 1 of the present invention, the patient need not turn upwards, so when administering the test drug in eye drops in the ophthalmologic examination room, the drug solution 100 can be administered while the patient is sitting. I can improve the nature.

  According to the ophthalmic medical solution dispenser 1 of the present invention, since at least one of the housing 10 and the fixing jig 3 is transparent or translucent, light enters the inside of the dispenser from the outside, and the patient can easily visually recognize it. It can confirm. Therefore, the chemical solution 100 can be accurately administered onto the surface of the eyeball 201 by pressing the discharge button 15 in a state where the chemical solution discharge port 20 can be seen directly in front.

According to the ophthalmic drug solution dispenser 1 of the present invention, the amount of drug solution (e.g., 0.001 to 7 [mu] L) to be discharged is much smaller than the amount of droplet (25 to 50 [mu] L) by drop administration of conventional eye drops. Therefore, the amount of the drug solution 100 discharged onto the surface of the eyeball 201 is very small, and there is no risk of the drug solution 100 flowing out of the eye, and all of the drug solution 100 can be effectively used.
Further, according to the ophthalmic drug solution administration device 1 of the present invention, a small amount of the drug solution 100 can be administered rather than the drop administration from the conventional eye drop container, and the influence of the drug solution 100 on the living body is reduced. There is a high degree of freedom in the design of the drug solution 100, such as being able to have a pH range, a wide osmotic pressure range, and a wide viscosity range. In addition, oily drug solutions can be administered without discomfort.
Furthermore, according to the ophthalmic drug solution administration device 1 of the first embodiment, since the drug solution 100 administered to the surface of the eye 201 can be made into a small amount of droplets, the patient feels discomfort in the eye 201 and the eye periphery 200 It can prevent you from feeling the stimulus.

  According to the ophthalmic drug solution administration device 1 of the present invention, the storage space 25 of the drug solution storage unit 21 is pressurized by the pressure application unit 26, and the drug solution administration member 11 is the eyeball 201 by the fixing jig 3. As there is no direct contact with the surrounding tissue, aseptic condition can be maintained for a long time. Therefore, it is possible to suppress contamination of the drug solution 100 by fungi and the like, and it is also possible to expect an effect of reducing and reducing the blending of additives such as preservatives to the drug solution 100.

  According to the ophthalmic drug solution administration device 1 of the present invention, since the electromagnetic valve jet system is adopted, the droplets are less likely to diffuse in the form of mist when discharged, and the amount of droplets adjusted (for example, 1 to 7000 nL ) Is also easy.

  According to the ophthalmic drug solution administration device 1 of the present invention, the drug solution administration member 11 is a cartridge type and can be replaced with a new drug solution delivery member 11, so that the ophthalmic drug solution administration device 1 can be reused. Contamination of the chemical solution 100 at the time of replenishment can also be prevented.

  According to the ophthalmic drug solution administration device 1 of the present invention, the chemical solution 100 is discharged by operating the discharge button 15 with the power switch 12 turned on, and the discharge button 15 is operated with the power switch 12 turned off. Since the liquid medicine 100 is not discharged even when operated, it is possible to prevent the liquid medicine 100 from being wasted by erroneously operating the discharge button 15 with the power switch 12 turned off.

In the embodiment described above, the distance between the eyeball 201 and the drug solution outlet 20 is maintained by gently pressing the fixing jig 3 against the eye peripheral portion 200, but the present invention is not limited to this. The fixing jig 3 may not be provided as shown in FIG.
In this case, the patient confirms that the drug solution discharge port 20 can be seen directly in front of the ophthalmic drug solution applicator 1 close to the eye 201 or in a state where the ophthalmic drug solution dispenser 1 lightly contacts the eye peripheral part 200. By pressing the discharge button 15, it is possible to precisely administer a microdroplet to the surface of the eyeball 201. In addition, when a third party such as a doctor or the like operates, it may be confirmed that the surface of the eye 201 and the chemical solution outlet 20 are on a straight line, and the discharge button 15 may be pressed.

  In the above-mentioned embodiment, although medical fluid administration member 11 was a cartridge method and was exchangeable, the present invention is not limited to this. The drug solution administration member 11 may be integral with the housing 10. In this case, when the chemical solution 100 disappears in the storage space 25 in the chemical solution storage unit 21, a new chemical solution 100 may be injected into the storage space 25 of the chemical solution storage unit 21 for reuse.

  In the above-described embodiment, the case where the patient holds the ophthalmic solution injector 1 in hand and lightly presses it on the eye peripheral portion 200 has been described, but the present invention is not limited to this. As an application, a rubber belt or the like may be used to attach to the eye periphery 200.

  In the embodiment described above, the fixing jig 3 is attached to each eye of the patient, and the ophthalmic drug administration device 1 for ophthalmic use for administering the drug solution 100 from the drug solution outlet 20 of one main body 2 has been described. Is not limited to this. For example, the ophthalmic drug solution injector 1 may be in the shape of a goggle type, and two main body units 2 may be provided so that the drug solution outlet 20 may face both eyes. That is, it may be used as the ophthalmic drug administration device 1 for both eyes. In this case, the drug solution 100 may be administered to one eye at a time, or the drug solution 100 may be administered to both eyes at one time.

  In the embodiment described above, the ophthalmic drug solution dispenser 1 is provided with one drug solution storage unit 21 in the main unit 2, but the present invention is not limited to this. A plurality of chemical solution reservoirs 21 may be provided in the main body 2 and a chemical solution outlet 20 corresponding thereto may be provided. By doing this, it is possible to simultaneously administer multiple types of drug solutions 100 to one eye. That is, simultaneous administration of multiple drugs to one eye is also possible.

In the embodiment described above, the ophthalmic drug solution dispenser 1 is provided with one drug solution outlet 20 in the drug solution administration member 11, but the present invention is not limited to this. The chemical solution dispensing member 11 may be provided with two or more chemical solution outlets 20. When providing several chemical | medical solution discharge ports 20 in the chemical | medical solution administration member 11, it is preferable that the number of the chemical | medical solution discharge ports 20 is two or more and ten or less.
If the number exceeds 10, the pressure in the storage space 25 may decrease and the drug solution 100 may not reach the eyeball 201.
For example, in the case where the drug solution dispensing member 11 is provided with one drug solution outlet 20, as shown in FIG. 8A, and in the case where the drug solution administering member 11 is provided with five drug solution outlets 20, FIG. It becomes like (b).

As an application example of the ophthalmic medical solution administration device 1 according to the above-described embodiment, the ophthalmic medical solution administration device 1 is provided with a mechanism for electronically recording the dosing information, or a mechanism for wirelessly distributing the dosing information from the ophthalmic medical solution administration device 1 May be By doing this, drug administration can be performed.
For example, by providing the doctor / pharmacist with data (memory) into which dosage information such as patient name (identification number), medicine type (drug name), dosing history (dosing date and time) is transferred, through a smartphone or personal computer It is possible to realize real-time medication management, such as preventing medication forgetting and misadministration.

  As an application of the ophthalmic drug solution administration device 1 according to the above-described embodiment, a light emitting unit may be provided on the inside or the outer periphery of the housing 10 or the outer periphery of the drug solution administration member 11. By doing this, the patient's own eye 201 and the eye peripheral part 200 can be brightly illuminated, and therefore, even when the third party such as a doctor operates, when accurately administering the drug solution 100 on the surface of the patient's eye 201. You can see that your eyes are open. The light emitting unit is not particularly limited as long as it is a light source such as a light emitting diode (LED) or an organic EL. Further, the shape of the light emitting portion is not particularly limited, and may be, for example, spherical, button-like, or ring-like.

  In the above-described embodiment, the chemical solution 100 in the storage space 25 is pressurized by the pressure application unit 26, which is a pressurizing unit, but the present invention is not limited to this. When filling the chemical solution 100, it may be pressurized and sealed, and the chemical solution 100 in the storage space 25 may be pressurized without using the pressure application unit 26.

  In the above-mentioned embodiment, although case part 10 was cylindrical, the present invention is not limited to this. The outer shape of the housing unit 10 may be flat or polygonal. Further, the shape of the internal space of the casing 10 is not particularly limited as long as the drug solution administration member 11 can be attached.

  Although the power switch 12 and the discharge button 15 are separately provided in the above embodiment, the present invention is not limited to this. The power switch 12 and the discharge button 15 may be one button or switch.

  In the embodiment described above, the pressure application unit 26 is built in the drug solution administration member 11, but the present invention is not limited to this. The pressure application unit 26 may be provided outside the drug solution administration member 11. For example, as shown in FIG. 9, when the pressure application unit 26 is provided on the inner wall of the housing unit 10, an elastic wall 60 in which a part or the whole of the wall constituting the drug solution administration member 11 is formed of an elastic body. Alternatively, the storage space 25 may be pressurized by pressing the elastic wall portion 60 by the pressure application unit 26 and causing elastic deformation.

DESCRIPTION OF SYMBOLS 1 ophthalmic drug solution dispenser 2 main body 3 fixing jig 10 case 11 drug solution dispenser 18 opening 20 drug solution outlet 21 drug reservoir 22 lid 23 drive 25 storage space 26 pressure applicator (pressurizing means)
100 drug solution 200 eye area 201 eye

Claims (9)

It has a drug solution administration member in the housing unit,
The chemical solution administration member includes a storage space for storing and pressurizing a chemical solution, a chemical solution discharge port for discharging a chemical solution from the storage space, a cover unit for closing the chemical solution discharge port, and a drive unit for opening and closing the cover unit. Have
An ophthalmic drug solution administration device characterized by discharging the drug solution in the storage space from the drug solution discharge port by driving the drive unit and opening the lid unit. With pressure means,
The ophthalmic medical solution dispenser according to claim 1, wherein the storage space is pressurized by the pressurizing unit.   The ophthalmic medical solution dispenser according to claim 1, wherein the housing unit includes a discharge button that is driven by the driving unit when pressed. A fixing jig for fixing the distance of the chemical solution outlet to the eye peripheral portion;
The ophthalmic medical solution dispenser according to any one of claims 1 to 3, wherein the fixing jig is connected to the housing unit.   The ophthalmic medical solution dispenser according to claim 4, wherein at least one of the casing and the fixing jig is transparent or semitransparent.   The ophthalmic drug solution administration device according to any one of claims 1 to 5, wherein the drug solution administration member includes one or more and 10 or less of the drug solution discharge ports.   The discharge amount of the chemical solution from the chemical solution discharge port when driving the drive unit and opening the lid is 1 nL or more and 7000 nL or less, according to any one of claims 1 to 6 Ophthalmic drug administration device.   The ophthalmic drug solution administration device according to any one of claims 1 to 7, wherein the drug solution administration member is attachable to and detachable from the housing unit. A chemical solution administration member removably mounted in a housing unit
It has a storage space for storing and pressurizing a chemical solution, a chemical solution discharge port for discharging a chemical solution from the storage space, a lid portion for closing the chemical solution outlet, and a drive portion for opening and closing the lid portion.
A chemical solution administration member characterized in that the chemical solution in the storage space is discharged from the chemical solution discharge port by driving the drive unit and opening the lid unit.