JP2019064984A - Cosmetic - Google Patents
Cosmetic Download PDFInfo
- Publication number
- JP2019064984A JP2019064984A JP2017194528A JP2017194528A JP2019064984A JP 2019064984 A JP2019064984 A JP 2019064984A JP 2017194528 A JP2017194528 A JP 2017194528A JP 2017194528 A JP2017194528 A JP 2017194528A JP 2019064984 A JP2019064984 A JP 2019064984A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- poe
- ascorbic acid
- extract
- oil
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002537 cosmetic Substances 0.000 title claims abstract description 44
- -1 ascorbic acid glucoside Chemical class 0.000 claims abstract description 69
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Natural products OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 46
- 229960005070 ascorbic acid Drugs 0.000 claims abstract description 42
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract description 38
- 239000011668 ascorbic acid Substances 0.000 claims abstract description 38
- 229930182478 glucoside Natural products 0.000 claims abstract description 33
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims abstract description 29
- 238000002845 discoloration Methods 0.000 claims abstract description 18
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims abstract description 15
- 235000019152 folic acid Nutrition 0.000 claims abstract description 14
- 239000011724 folic acid Substances 0.000 claims abstract description 14
- 229960000304 folic acid Drugs 0.000 claims abstract description 14
- 238000000034 method Methods 0.000 claims abstract description 9
- 230000002123 temporal effect Effects 0.000 claims abstract description 4
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 15
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims description 11
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
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- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 5
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- DZKXJUASMGQEMA-UHFFFAOYSA-N tetradecyl tetradecanoate Chemical compound CCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCC DZKXJUASMGQEMA-UHFFFAOYSA-N 0.000 description 1
- KWXLCDNSEHTOCB-UHFFFAOYSA-J tetrasodium;1,1-diphosphonatoethanol Chemical compound [Na+].[Na+].[Na+].[Na+].[O-]P(=O)([O-])C(O)(C)P([O-])([O-])=O KWXLCDNSEHTOCB-UHFFFAOYSA-J 0.000 description 1
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Landscapes
- Cosmetics (AREA)
Abstract
Description
本発明は、長期間の経時による変色を抑制しうるアスコルビン酸グルコシドを配合した化粧料、およびアスコルビン酸グルコシドを配合した化粧料において、長期間の経時による変色を抑制する方法に関する。 The present invention relates to a cosmetic composition containing ascorbic acid glucoside capable of suppressing discoloration over a long period of time and a method of suppressing discoloration over a long period of time in a cosmetic composition containing ascorbic acid glucoside.
従来、高い美白効果を期待して、アスコルビン酸及びその誘導体を配合した化粧料が開発されてきたが、アスコルビン酸は化学的に不安定であることから、酸化され難く安定なアスコルビン酸グルコシドを化粧料に配合することが提案されている(例えば、特許文献1〜2参照)。 In the past, cosmetic products containing ascorbic acid and its derivatives have been developed in anticipation of a high whitening effect, but ascorbic acid is chemically unstable and so it is difficult to oxidize and cosmetic stable ascorbic acid glucoside is applied. It is proposed to mix it in a filler (see, for example, Patent Documents 1 and 2).
しかしながらアスコルビン酸グルコシドも経時により変色が生じることから、これに対して特許文献3ではレシチンとキレート剤を併用することにより解決を試みているが、このような試みに拠っても、ある程度の変色抑制はできるものの、長期間の経時ではアスコルビン酸グルコシドが分解してしまい、化粧料の変色を充分に抑制できるとはいえないものであった。 However, as ascorbic acid glucoside also causes discoloration due to the passage of time, Patent Document 3 attempts to solve the problem by using lecithin and a chelating agent in combination. Although it was possible, ascorbic acid glucoside was decomposed in long-term aging, and it could not be said that discoloration of the cosmetic could be sufficiently suppressed.
本発明はこのような従来の問題点を解決するためになされたもので、長期間の経時においても変色の少ないアスコルビン酸グルコシドを配合した化粧料、およびアスコルビン酸グルコシドを配合した化粧料の変色を抑制する方法を提供することを目的とするものである。 The present invention was made in order to solve such conventional problems, and it is an object of the present invention to provide a cosmetic composition containing ascorbic acid glucoside, which is less likely to discolor even during long-term aging, and a cosmetic composition containing ascorbic acid glucoside. The purpose is to provide a method of suppressing.
本発明者は上記課題を解決すべく鋭意検討した結果、アスコルビン酸グルコシドを配合した化粧料に葉酸を添加することで、従来にない長期間保存した際の変色を抑制したアスコルビン酸グルコシド配合化粧料が得られることを見出し、本発明を完成させるに至った。 As a result of intensive investigations to solve the above problems, the present inventor added ascorbic acid glucoside-containing cosmetic which suppressed discoloration when stored for a long period of time by adding folic acid to cosmetics containing ascorbic acid glucoside. It has been found that the present invention is obtained.
本願第一の発明は、下記成分(a)〜(b)を含有することを特徴とする化粧料である。(a)アスコルビン酸グルコシド
(b)葉酸
The first invention of the present application is a cosmetic comprising the following components (a) to (b). (A) ascorbic acid glucoside (b) folic acid
本願第二の発明は、さらに成分(c)としてトコフェロール及びその誘導体から選ばれる1種類以上を含有することを特徴とする本願第一の発明に記載の化粧料である。 The second invention of the present application is the cosmetic according to the first invention, further comprising one or more selected from tocopherol and its derivative as the component (c).
本願第三の発明は、アスコルビン酸グルコシドを含有する化粧料に、下記成分(b)を添加することにより、アスコルビン酸グルコシドを含有する化粧料の経時的な変色を抑制する方法である。
(b)葉酸
The third invention of the present application is a method of suppressing temporal discoloration of a cosmetic containing ascorbic acid glucoside by adding the following component (b) to a cosmetic containing ascorbic acid glucoside.
(B) folic acid
本願第四の発明は、アスコルビン酸グルコシドを含有する化粧料に、下記成分(b)および(c)を添加することにより、アスコルビン酸グルコシドを含有する化粧料の経時的な変色を抑制する方法である。
(b)葉酸
(c)トコフェロール及びその誘導体
The fourth invention of the present application is a method for suppressing discoloration of ascorbic acid glucoside-containing cosmetic with time by adding the following components (b) and (c) to ascorbic acid glucoside-containing cosmetic. is there.
(B) folic acid (c) tocopherol and its derivatives
本発明によれば、長期間の経時においても変色の少ないアスコルビン酸グルコシドを配合した化粧料、およびアスコルビン酸グルコシドを配合した化粧料の変色を抑制する方法を提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, the cosmetics which mix | blended ascorbic-acid glucoside with few discolorations even with long-term time-lapse | temporality and the method of suppressing discoloration of cosmetics which mix | blended ascorbic-acid glucoside can be provided.
以下、本発明を詳細に説明する。 Hereinafter, the present invention will be described in detail.
本発明で配合される成分(a)は、アスコルビン酸グルコシドであれば特に限定されないが、α−グリコシル−L−アスコルビン酸が安定性に優れ好ましく、特に好ましくは2−O−α−D−グルコシル−L−アスコルビン酸である。 The component (a) to be blended in the present invention is not particularly limited as long as it is ascorbic acid glucoside, but α-glycosyl-L-ascorbic acid is excellent in stability and preferable, and particularly preferably 2-O-α-D-glucosyl -L-ascorbic acid.
上記成分(a)アスコルビン酸グルコシドの含有量は、特に限定されないが、化粧料の総量を基準として、0.1質量%以上〜10質量%以下が好ましく、さらに好ましくは1質量%以上〜3質量%以下である。0.1質量%未満では美白効果が充分ではなく、また10質量%を超えるとアスコルビン酸グルコシド自体を化粧料に安定配合することが困難である。 The content of the component (a) ascorbic acid glucoside is not particularly limited, but is preferably 0.1% by mass to 10% by mass, and more preferably 1% by mass to 3% by mass, based on the total amount of the cosmetic. % Or less. When the amount is less than 0.1% by mass, the whitening effect is not sufficient. When the amount is more than 10% by mass, it is difficult to stably mix ascorbic acid glucoside itself with the cosmetic.
本発明で用いられる成分(b)としての葉酸は、ビタミンB9やビタミンM、プテロイルグルタミン酸とも呼ばれる水溶性ビタミンである。 Folic acid as the component (b) used in the present invention is a water-soluble vitamin also called vitamin B9, vitamin M or pteroyl glutamic acid.
上記成分(b)の含有量は、特に限定されないが、化粧料の総量を基準として、0.0001質量%以上〜0.5質量%以下が好ましく、さらに好ましくは0.001質量%以上〜0.1質量%以下である。 0.0001質量%未満では変色抑制効果が充分ではなく、また0.5質量%を超えると化粧料に安定配合することが困難である。 Although content of the said component (b) is not specifically limited, 0.0001 mass% or more and 0.5 mass% or less are preferable on the basis of the total amount of cosmetics, More preferably, 0.001 mass% or more-0 .1% by mass or less. When the amount is less than 0.0001% by mass, the discoloration inhibiting effect is not sufficient. When the amount is more than 0.5% by mass, it is difficult to stably blend in the cosmetic.
本発明で配合される成分(c)としてのトコフェロール及びその誘導体は、dl−α−トコフェロール、dl−β−トコフェロール、dl−γ−トコフェロール、dl−δ−トコフェロール、酢酸dl−α−トコフェロール、ニコチン酸−dl−α−トコフェロール、コハク酸dl−α−トコフェロール、リノール酸−dl−α−トコフェロール等が挙げられ、天然ビタミンE等も含む。この中でdl−α−トコフェロール、ニコチン酸−dl−α−トコフェロールが好ましい。 Tocopherol and its derivatives as component (c) formulated in the present invention are dl-α-tocopherol, dl-β-tocopherol, dl-γ-tocopherol, dl-δ-tocopherol, dl-α-tocopherol acetate, nicotine Examples thereof include acid-dl-α-tocopherol, succinic acid dl-α-tocopherol, linoleic acid-dl-α-tocopherol and the like, as well as natural vitamin E and the like. Among these, dl-α-tocopherol and nicotinic acid-dl-α-tocopherol are preferable.
上記成分(c)トコフェロール及びその誘導体の含有量は、特に限定されないが、化粧料の総量を基準として、0.0001質量%以上〜1質量%以下が好ましく、さらに好ましくは0.01質量%以上〜0.2質量%以下である。0.0001質量%未満では変色抑制効果が充分ではなく、また1質量%を超えると化粧料に安定配合することが困難である。 Although content of the said component (c) tocopherol and its derivative is not specifically limited, 0.0001 mass% or more and 1 mass% or less are preferable on the basis of the total amount of cosmetics, More preferably, 0.01 mass% or more It is -0.2 mass% or less. When the amount is less than 0.0001% by mass, the discoloration inhibiting effect is not sufficient, and when the amount is more than 1% by mass, it is difficult to stably blend in a cosmetic.
上記化粧料には、上記の必須成分に加えて、本発明の効果を損なわない範囲内で、化粧料に一般に配合し得る成分を任意に添加することができる。このような成分としては、例えばビタミン類、固体油脂、ロウ類、シリコーン、保湿剤、カチオン界面活性剤、両性界面活性剤、親油性非イオン界面活性剤、親水性非イオン界面活性剤、防腐剤、消炎剤、美白剤、植物抽出物、賦活剤、血行促進剤、抗脂漏剤、天然の水溶性高分子、半合成水溶性高
分子、合成水溶性高分子、無機の水溶性高分子、粉末成分、金属イオン封鎖剤、水、香料、低級アルコール等が挙げられる。ただしこれら例示に限定されるものでない。
In addition to the above-described essential components, components that can be generally blended with cosmetics can be optionally added to the above-described cosmetic, as long as the effects of the present invention are not impaired. Such components include, for example, vitamins, solid fats and oils, waxes, silicones, moisturizers, cationic surfactants, amphoteric surfactants, lipophilic nonionic surfactants, hydrophilic nonionic surfactants, preservatives Anti-inflammatory agent, Whitening agent, Plant extract, Activator, Blood circulation promoter, Antiseborrhea agent, Natural water soluble polymer, Semi-synthetic water soluble polymer, Synthetic water soluble polymer, Inorganic water soluble polymer, Powder components, sequestering agents, water, flavors, lower alcohols and the like can be mentioned. However, it is not limited to these examples.
ビタミン類としては、ビタミン油、レチノール、酢酸レチノール等のビタミンA類、リボフラビン、酪酸リボフラビン、フラビンアデニンヌクレオチド等のビタミンB2類、ピリドキシン塩酸塩、ピリドキシンジオクタノエート等のビタミンB6類、L−アスコルビン酸、L−アスコルビン酸ジパルミチン酸エステル、L−アスコルビン酸−2−硫酸ナトリウム、L−アスコルビン酸リン酸エステル、DL−α−トコフェロール−L−アスコルビン酸リン酸ジエステルジカリウム、エチルアスコルビン酸等のビタミンC類、パントテン酸カルシウム、D−パントテニルアルコール、パントテニルエチルエーテル、アセチルパントテニルエチルエーテル等のパントテン酸類、エルゴカルシフェロール、コレカルシフェロール等のビタミンD類、ニコチン酸、ニコチン酸アミド、ニコチン酸ベンジル等のニコチン酸類、ビタミンP、ビオチンなど例示される。 As vitamins, vitamin oil, retinol, vitamin A such as retinol acetate, riboflavin, vitamin B 2 such as riboflavin butyrate, flavin adenine nucleotide, pyridoxine hydrochloride, vitamin B 6 such as pyridoxine dioctanoate, L -Ascorbic acid, L-ascorbic acid dipalmitate, L-ascorbic acid sodium 2-sulfate, L-ascorbic acid phosphate, DL-α-tocopherol-L-ascorbic acid diester dipotassium, ethyl ascorbic acid, etc. Vitamin C, pantothenic acid calcium, D-pantothenyl alcohol, pantothenyl ethyl ether, pantothenic acid such as acetyl pantothenyl ethyl ether, vitamin D such as ergocalciferol, cholecalciferol, Examples thereof include nicotinic acid, nicotinic acid amide, nicotinic acid such as benzyl nicotinate, vitamin P, biotin and the like.
液状油としては、流動パラフィン、オゾケライト、スクワラン、等の炭化水素油、アボカド油、ツバキ油、月見草油、マカデミアナッツ油、トウモロコシ油、ミンク油、オリーブ油、ナタネ油、卵黄油、ゴマ油、パーシック油、小麦胚芽油、サザンカ油、ヒマシ油、アマニ油、サフラワー油、綿実油、エノ油、大豆油、落花生油、茶実油、カヤ油、コメヌカ油、シナギリ油、日本キリ油、ホホバ油、胚芽油、トリグリセリド、トリオクタン酸グリセリン、トリイソパルミチン酸グリセリン等の液体油脂、ミリスチン酸イソプロピル、オクタン酸セチル、ミリスチン酸オクチルドデシル、パルミチン酸イソプロピル、ステアリン酸ブチル、ラウリン酸ヘキシル、ミリスチン酸ミリスチル、オレイン酸デシル、ジメチルオクタン酸ヘキシルデシル、乳酸セチル、乳酸ミリスチル、酢酸ラノリン、ステアリン酸イソセチル、イソステアリン酸イソセチル、ジ−2−エチルヘキサン酸エチレングリコール、ジペンタエリスリトール脂肪酸エステル、モノイソステアリン酸N−アルキルグリコール、ジカプリン酸ネオペンチルグリコール、リンゴ酸ジイソステアリル、ジ−2−ヘプチルウンデカン酸グリセリル、トリ−2−エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ−2−エチルヘキサン酸ペンタンエリスリトール、トリー2−エチルヘキサン酸グリセリル、セチル2−エチルヘキサノエート、2−エチルヘキシルパルミテート、トリミリスチン酸グリセリル、トリ−2−ヘプチルウンデカン酸グリセリル、ヒマシ油脂肪酸メチルエステル、オレイン酸オレイル、酢酸グリセリル、パルミチン酸2−ヘプチルウンデシル、アジピン酸ジイソブチル、アジピン酸ジ−2−ヘプチルウンデシル、エチルラウレート、セバチン酸ジ−2−エチルヘキシル、ミリスチン酸2−ヘキシルデシル、パルミチン酸2−ヘキシルデシル、アジピン酸2−ヘキシルデシル、セバチン酸ジイソプロピル、コハク酸2−エチルヘキシル、酢酸エチル、酢酸ブチル、酢酸アミル、クエン酸トリエチル、シクロヘキサン−1,4−ジカルボン酸ビスエトキシジグリコール等の合成エステル油などが例示される。 As liquid oil, hydrocarbon oil such as liquid paraffin, ozokerite, squalane etc., avocado oil, camellia oil, evening primrose oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, sesame oil, wheat Germ oil, sasanqua oil, castor oil, linseed oil, safflower oil, cottonseed oil, cotton oil, soybean oil, peanut oil, peanut oil, tea seed oil, kaaya oil, rice bran oil, Japanese oak oil, Japanese prickly oil, jojoba oil, germ oil, Liquid fats and oils such as triglyceride, glycerin trioctanoate, glycerin triisopalmitate, isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, dimethyl Hexyldecyl octanoate Cetyl lactate, myristyl lactate, lanolin acetate, isocetyl stearate, isocetyl isostearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, N-alkyl glycol monoisostearate, neopentyl glycol dicaprate, malic acid diacetate Isostearyl, glyceryl di-2-heptylundecanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, pentaneerythritol tetra-2-ethylhexanoate, glyceryl tri-2-ethylhexanoate, cetyl 2 -Ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, glyceryl tri-2-heptylundecanoate, castor oil fatty acid methyl ester Oleyl oleate, glyceryl acetate, 2-heptylundecyl palmitate, diisobutyl adipate, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyl decyl myristate, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate, cyclohexane-1,4-dicarboxylate bisethoxy diglycol etc. And synthetic ester oils of
固体油脂としては、カカオ脂、ヤシ油、馬脂、硬化ヤシ油、パーム油、牛脂、羊脂、硬化牛脂、パーム核油、豚脂、牛骨脂、モクロウ核油、硬化油、牛脚脂、モクロウ、硬化ヒマシ油などが例示される。 As solid fats and oils, cacao butter, coconut oil, horse fat, hydrogenated coconut oil, palm oil, beef tallow, goat fat, hydrogenated beef tallow, palm kernel oil, pork fat, beef bone fat, mokurou kernel oil, hydrogenated oil, beef leg fat Mokurou, hydrogenated castor oil, etc. are exemplified.
ロウ類としては、ミツロウ、カンデリラロウ、綿ロウ、カルナウバロウ、ベイベリーロウ、イボタロウ、鯨ロウ、モンタンロウ、ヌカロウ、ラノリン、カポックロウ、液状ラノリン、サトウキビロウ、ラノリン脂肪酸イソプロピル、ラウリン酸ヘキシル、還元ラノリン、ジョジョバロウ、硬質ラノリン、セラックロウ、POEラノリンアルコールエーテル、POEラノリンアルコールアセテート、POEコレステロールエーテル、ラノリン脂肪酸ポリエチレングリコール、POE水素添加ラノリンアルコールエーテルなどが例示される。 Waxes include beeswax, candelilla wax, cotton wax, carnauba wax, bayberry wax, ivory wax, persimmon wax, montan wax, nuka wax, lanolin, kapok wax, liquid lanolin, sugar cane wax, lanolin fatty acid isopropyl, hexyl laurate, reduced lanolin, jojo bavar, hard Lanolin, shellac wax, POE lanolin alcohol ether, POE lanolin alcohol acetate, POE cholesterol ether, lanolin fatty acid polyethylene glycol, POE hydrogenated lanolin alcohol ether, etc. may be mentioned.
シリコーンとしては、ジメチルポリシロキサン、メチルフェニルポリシロキサン、メチルハイドロジェンポリシロキサン等の鎖状ポリシロキサン、デカメチルシクロペンタシロキサン、ドデカメチルシクロヘキサシロキサン、テトラヒドロテトラメチルシクロテトラシロキサン等の環状ポリシロキサン、3次元網目構造を形成しているシリコ−ン樹脂、シリコーンゴムなどが例示される。 Examples of silicones include linear polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane and methylhydrogenpolysiloxane, cyclic polysiloxanes such as decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane and tetrahydrotetramethylcyclotetrasiloxane, 3 Examples thereof include silicone resin, silicone rubber and the like forming a dimensional network structure.
保湿剤としては、ポリエチレングリコール、プロピレングリコール、グリセリン、1,3−ブチレングリコール、ジプロピレングリコール、1,3−プロパンジオール、ヘキシレングリコール、キシリトール、ソルビトール、コンドロイチン硫酸、ヒアルロン酸、ムコイチン硫酸、カロニン酸、アテロコラーゲン、メチルグルセス−20、乳酸ナトリウム、胆汁酸塩、dl−ピロリドンカルボン酸塩、短鎖可溶性コラーゲン、ジグリセリン(EO)PO付加物、イサイヨバラ抽出物、セイヨウノキギリソウ抽出物、メリロート抽出物などが例示される。 As a moisturizer, polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, dipropylene glycol, 1,3-propanediol, hexylene glycol, xylitol, sorbitol, chondroitin sulfate, hyaluronic acid, mucotin sulfate, caronic acid , Atelocollagen, methyl gluceth -20, sodium lactate, bile salt, dl-pyrrolidone carboxylate, short chain soluble collagen, diglycerin (EO) PO adduct, extract of Ii yobara, extract of Achillea vermicelli, extract of melilote, etc. Is illustrated.
カチオン界面活性剤としては、塩化ステアリルトリメチルアンモニウム、塩化ラウリルトリメチルアンモニウム等のアルキルトリメチルアンモニウム塩、塩化ジステアリルジメチルアンモニウムジアルキルジメチルアンモニウム塩、塩化ポリ(N,N’−ジメチル−3,5−メチレンピペリジニウム)、塩化セチルピリジニウム等のアルキルピリジニウム塩のほか、アルキル四級アンモニウム塩、アルキルジメチルベンジルアンモニウム塩、アルキルイソキノリニウム塩、ジアルキルモルホリニウム塩、POEアルキルアミン、アルキルアミン塩、ポリアミン脂肪酸誘導体、アミルアルコール脂肪酸誘導体、塩化ベンザルコニウム、塩化ベンゼトニウムなどが例示される。 As cationic surfactants, alkyltrimethyl ammonium salts such as stearyl trimethyl ammonium chloride and lauryl trimethyl ammonium chloride, distearyl dimethyl ammonium dialkyl dialkyl ammonium salts such as distearyl dimethyl ammonium chloride, poly (N, N'-dimethyl-3,5-methylene piperidine chloride) And alkyl pyridinium salts such as cetyl pyridinium chloride, alkyl quaternary ammonium salts, alkyl dimethyl benzyl ammonium salts, alkyl isoquinolinium salts, dialkyl morpholinium salts, POE alkyl amines, alkyl amine salts, polyamine fatty acid derivatives And amyl alcohol fatty acid derivatives, benzalkonium chloride, benzethonium chloride and the like.
両性界面活性剤としては、2−ウンデシル−N−ヒドロキシエチル−N−カルボキシメチルイミダゾリニウムベタインナトリウム、2−ココイル−2−イミタゾリニウムヒドロキサイド−1−カルボキシエチロキシ2ナトリウム塩等のイミダゾリン系両性界面活性剤、2−ヘプタデシル−N−カルボキシメチル−N−ヒドロキシエチルイミダゾリニウムベタイン、ラウリルジメチルアミノ酢酸ベタイン、アルキルベタイン、アミドベタイン、スルホベタイン等のベタイン系界面活性剤などが例示される。 Examples of amphoteric surfactants include imidazolines such as 2-undecyl-N-hydroxyethyl-N-carboxymethylimidazolinium sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxydisodium salt, etc. Amphoteric surfactants, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaines, lauryl dimethylaminoacetic acid betaines, alkylbetaines, amidobetaines, betabetas surfactants such as sulfobetaines, etc. are exemplified. .
親油性非イオン界面活性剤としては、ソルビタンモノオレエート、ソルビタンモノイソステアレート、ソルビタンモノラウレート、ソルビタンモノパルミテート、ソルビタンモノステアレート、ソルビタンセスキオレエート、ソルビタントリオレエート、ペンタ−2−エチルヘキサン酸ジグリセロールソルビタン、テトラ−2−エチルヘキサン酸ジグリセロールソルビタン等のソルビタン脂肪酸エステル類、モノ綿実油脂肪酸グリセリン、モノエルカ酸グリセリン、セスキオレイン酸グリセリン、モノステアリン酸グリセリン、ピログルタミン酸オレイン酸グリセリル、ステアリン酸リンゴ酸グリセリル等のグリセリン脂肪酸類、モノステアリン酸プロピレングリコール等のプロピレングリコール脂肪酸エステル類のほか、硬化ヒマシ油誘導体、ポリオキシエチレン・メチルポリシロキサン共重合体などが例示される。 Examples of lipophilic nonionic surfactants include sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, penta-2-ethyl Sorbitan fatty acid esters such as diglycerol sorbitan hexanoate and diglycerol sorbitan tetra-2-ethylhexanoate, mono cottonseed oil fatty acid glycerin, glycerin monoerucate, glycerin sesquioleate, glycerin monostearate, glycerol glyceryl oleate oleate, stearic acid Glycerin fatty acids such as glyceryl malate, propylene glycol fatty acid esters such as propylene glycol monostearate, and hydrogenated castor oil , Polyoxyethylene-methylpolysiloxane copolymer etc. can be exemplified.
親水性非イオン界面活性剤としては、POEソルビタンモノオレエート、POE−ソルビタンモノステアレート、POE−ソルビタンテトラオレエート等のPOEソルビタン脂肪酸エステル類、POE−ソルビットモノラウレート、POE−ソルビットモノオレエート、POE−ソルビットペンタオレエート、POE−ソルビットモノステアレート等のPOEソルビット脂肪酸エステル類、POE−グリセリンモノステアレート、POE−グリセリンモノイソステアレート、POE−グリセリントリイソステアレート等のPOEグリセリン脂肪酸エステル類、POEモノオレエート、POEジステアレート、POEジオレエート、ジステアリン酸エチレングリコール等のPOE脂肪酸エステル類、POEラウリルエーテル、POEオレイルエーテル、POEステアリルエーテル、POEベヘニルエーテ
ル、POE2−オクチルドデシルエーテル、POEコレスタノールエーテル等のPOEアルキルエーテル類、POEオクチルフェニルエーテル、POEノニルフェニルエーテル、POEジノニルフェニルエーテル等のPOEアルキルフェニルエーテル類、POE・POPグリコール等のプルロニック型類、テトロニック等のテトラPOE・テトラPOPエチレンジアミン縮合物類、POEヒマシ油、POE硬化ヒマシ油、POE硬化ヒマシ油モノイソステアレート、POE硬化ヒマシ油トリイソステアレート、POE硬化ヒマシ油モノピログルタミン酸モノイソステアリン酸ジエステル、POE硬化ヒマシ油マレイン酸等のPOEヒマシ油硬化ヒマシ油誘導体、POEソルビットミツロウ等のPOEミツロウ・ラノリン誘導体、ヤシ油脂肪酸ジエタノールアミド、ラウリン酸モノエタノールアミド、脂肪酸イソプロパノールアミド等のアルカノールアミドのほか、POEプロピレングリコール脂肪酸エステル、POEアルキルアミン、POE脂肪酸アミド、ショ糖脂肪酸エステル、POEノニルフェニルホルムアルデヒド縮合物、アルキルエトキシジメチルアミンオキシド、トリオレイルリン酸などが例示される。
Examples of hydrophilic nonionic surfactants include POE sorbitan monooleate, POE-sorbitan monostearate, POE sorbitan fatty acid esters such as POE-sorbitan tetraoleate, POE-sorbit monolaurate, POE-sorbit monooleate , POE-Sorbit pentaoleate, POE-Sorbit fatty acid esters such as POE-Sorbit monostearate POE-Glycerin monostearate, POE-Glycerin monoisostearate, POE-Glycerin fatty acid ester such as POE-Glycerin triisostearate Fatty acid esters such as POE monooleate, POE distearate, POE dioleate, ethylene glycol distearate, POE lauryl ether, POE oleyl ether POE alkyl ethers such as POE stearyl ether, POE behenyl ether, POE 2-octyldodecyl ether, POE cholestanol ether, POE octyl phenyl ether, POE nonyl phenyl ether, POE alkyl ether such as POE dinonyl phenyl ether, Pluronic types such as POE / POP glycol, tetra POE / tetra POP ethylene diamine condensates such as tetronic, POE castor oil, POE hydrogenated castor oil, POE hydrogenated castor oil monoisostearate, POE hydrogenated castor oil triisostearate POE castor oil cured castor oil derivative such as POE hydrogenated castor oil monopyroglutamic acid monoisostearic acid diester POE hydrogenated castor oil maleic acid POE solbitomi POE beeswax lanolin derivatives such as waxes, alkanolamides such as coconut oil fatty acid diethanolamide, lauric acid monoethanolamide, fatty acid isopropanolamide, POE propylene glycol fatty acid ester, POE alkylamine, POE fatty acid amide, sucrose fatty acid ester, POE nonyl phenyl formaldehyde condensate, alkyl ethoxy dimethyl amine oxide, trioleyl phosphoric acid and the like are exemplified.
防腐剤としては、メチルパラベン、エチルパラベン、ブチルパラベン、プロピルパラベン、フェノキシエタノール、レゾルシン、サリチル酸、デヒドロ酢酸、ヘキサクロロフェン、塩化ベンザルコニウム、イソプロピルメチルフェノール、アルカンジオール等が例示される。 Examples of preservatives include methylparaben, ethylparaben, butylparaben, propylparaben, phenoxyethanol, resorcin, salicylic acid, dehydroacetic acid, hexachlorophene, benzalkonium chloride, isopropylmethylphenol, alkanediol and the like.
消炎剤としては、グリチルリチン酸誘導体、グリチルレチン酸誘導体、サリチル酸誘導体、ヒノキチオール、酸化亜鉛、アラントイン等が例示される。 Examples of the anti-inflammatory agent include glycyrrhizinic acid derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, allantoin and the like.
美白剤としては、アスコルビン酸、アスコルビン酸誘導体、プラセンターエキス、アルブチン、トラネキサム酸、コウジ酸、イオウ、油溶性甘草抽出物、ユキノシタ抽出物等が例示される。 Examples of the skin lightening agent include ascorbic acid, ascorbic acid derivatives, placenta extract, arbutin, tranexamic acid, kojic acid, sulfur, oil-soluble licorice extract, yukinoshita extract and the like.
植物抽出物としては、オウバク、オウゴン、シコン、シャクヤク、センブリ、バーチ、セージ、ビワ、ニンジン、アロエ、ゼニアオイ、アイリス、ブドウ、ヨクイニン、ヘチマ、ユリ、サフラン、センキュウ、ショウキュウ、オトギリソウ、オノニス、ローズマリー、ニンニク、トウガラシ、チンピ、トウキ、海藻、茶等の抽出物が例示される。 As a plant extract, ginseng, augon, sikonyaku, peony, semuri, birch, sage, loquat, carrots, aloe, zenia oide, iris, grapes, yokuinin, raspberry, lily, saffron, leek, ginseng, oonilis, rose Examples of the extract include mario, garlic, pepper, chimpanzee, touki, seaweed, tea and the like.
賦活剤としては、ローヤルゼリー、感光素、コレステロール誘導体等が例示される。 Examples of the activator include royal jelly, photosensitizer, cholesterol derivative and the like.
血行促進剤としては、ノニル酸ワレニルアミド、ニコチン酸ベンジルエステル、ニコチン酸β−ブトキシエチルエステル、カプサイシン、ジンゲロン、カンタリスチンキ、イクタモール、カフェイン、タンニン酸、α−ボルネオール、ニコチン酸トコフェロール、イノシトールヘキサニコチネート、シクランデレート、シンナリジン、トラゾリン、アセチルコリン、ベラパミル、セファランチン、γ−オリザノール等が例示される。 As a blood circulation promoter, nonyl acid warenylamide, nicotinic acid benzyl ester, nicotinic acid β-butoxyethyl ester, capsaicin, zingerone, cantaristine key, ictamol, caffeine, tannic acid, α-borneol, tocopherol nicotinate, inositol hexanicoti Nate, cichrandelate, cinnarizine, trazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol and the like are exemplified.
抗脂漏剤としては、硫黄、チアントール等が例示される。 Examples of the anti-seborrhea agent include sulfur, thianthol and the like.
天然の水溶性高分子としては、アラアビアガム、トラガカントガム、ガラクタン、グアーガム、ローカストビーンガム、タマリントガム、キャロブガム、カラヤガム、カラギーナン、ペクチン、カンテン、クインスシード(マルメロ)、アルゲコロイド(カッソウエキス)、デンプン(コメ、トウモロコシ、バレイショ、コムギ)等の植物系水溶性高分子、キサンタンガム、デキストラン、サクシノグルカン、ブルラン等の微生物系水溶性高分子、コラーゲン、カゼイン、アルブミン、ゼラチン等の動物系水溶性高分子などが例示される。 Examples of natural water-soluble polymers include arabia gum, tragacanth gum, galactan, guar gum, locust bean gum, tamarint gum, carob gum, caraya gum, carrageenan, pectin, agartenite, quince seed (marello), alge colloid (kasou extract), starch (rice, corn) Water-soluble polymers of plants such as potato, wheat), water-soluble polymers of microorganisms such as xanthan gum, dextran, succinoglucan, bullan, water-soluble polymers of animals such as collagen, casein, albumin, gelatin, etc. Be done.
半合成水溶性高分子としては、カルボキシメチルデンプン、メチルヒドロキシプロピルデ
ンプン等のデンプン系水溶性高分子、メチルセルロース、ニトロセルロース、エチルセルロース、メチルヒドロキシプロピルセルロース、ヒドロキシエチルセルロース、セルロース硫酸ナトリウム、ヒドロキシプロピルセルロース、カルボキシメチルセルロース(CMC)、結晶セルロース、セルロース末等のセルロース系水溶性高分子、アルギン酸ナトリウム、アルギン酸プロピレングリコールエステル等のアルギン酸系水溶性高分子などが例示される。
Examples of semi-synthetic water-soluble polymers include starch-based water-soluble polymers such as carboxymethyl starch and methylhydroxypropyl starch, methylcellulose, nitrocellulose, ethylcellulose, methylhydroxypropylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose and carboxy Examples include cellulose-based water-soluble polymers such as methyl cellulose (CMC), crystalline cellulose and cellulose powder, and alginate-based water-soluble polymers such as sodium alginate and propylene glycol alginate.
合成水溶性高分子としては、ポリビニルアルコール、ポリビニルメチルエーテル、ポリビニルピロリドン、カルボキシビニルポリマー(カーボポール)等のビニル系水溶性高分子、ポリエチレングリコール1,000、同6,000、同20,000等のポリオキシエチレン系水溶性高分子、ポリオキシエチレンポリオキシプロピレン共重合体等の共重合系水溶性高分子、ポリアクリル酸ナトリウム、ポリエチルアクリレート、ポリアクリルアミド等のアクリル系水溶性高分子のほか、ポリエチレンイミン、カチオンポリマーなどが例示される。 Examples of synthetic water-soluble polymers include polyvinyl water-soluble polymers such as polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, carboxy vinyl polymer (Carbopol), polyethylene glycols 1,000, 6,000, 20,000, etc. In addition to water soluble polymers of polyoxyethylene type, copolymer type water soluble polymers such as polyoxyethylene polyoxypropylene copolymer, and acrylic type water soluble polymers such as sodium polyacrylate, polyethyl acrylate and polyacrylamide. , Polyethylene imine, cationic polymers and the like.
無機の水溶性高分子としては、ベントナイト、ケイ酸AlMg(ビーガム)、ラポナイト、ヘクトライト、無水ケイ酸などが例示される。 Examples of inorganic water-soluble polymers include bentonite, AlMg silicate (bee gum), laponite, hectorite, silicic acid anhydride and the like.
粉末成分としては、例えば、無機粉末(例えば、タルク、カオリン、ベントナイト、ケイ酸アルミン酸マグネシウム、酸化チタン、酸化亜鉛等)、有機粉末(例えば、セルロース粉末等)、無機顔料(例えば、三二酸化鉄、黄色三二酸化鉄、黒酸化鉄等)、有機顔料(例えば、アルミニウムレーキ等)などが例示される。 As a powder component, for example, inorganic powder (for example, talc, kaolin, bentonite, magnesium aluminate, titanium oxide, zinc oxide etc.), organic powder (eg cellulose powder etc.), inorganic pigment (for example, ferric oxide) Yellow ferric oxide, black iron oxide, etc.), organic pigments (eg, aluminum lake, etc.), etc.
金属イオン封鎖剤としては、1−ヒドロキシエタン−1,1−ジホスホン酸、1−ヒドロキシエタン−1,1−ジホスホン酸四ナトリウム塩、エデト酸二ナトウム、エデト酸三ナトリウム、エデト酸四ナトリウム、クエン酸ナトリウム、ポリリン酸ナトリウム、メタリン酸ナトリウム、グルコン酸、リン酸、クエン酸、アスコルビン酸、コハク酸、エデト酸、HEDTA−3Naなどが例示される。 As sequestering agents, 1-hydroxyethane-1,1-diphosphonic acid, 1-hydroxyethane-1,1-diphosphonic acid tetrasodium salt, disodium edetate, trisodium edetate, tetrasodium edetate, citric acid Examples thereof include sodium acid, sodium polyphosphate, sodium metaphosphate, gluconic acid, phosphoric acid, citric acid, ascorbic acid, succinic acid, edetic acid, HEDTA-3Na and the like.
低級アルコールとしては、エタノール、プロパノール、イソプロパノール、イソブチルアルコール、t−ブチルアルコール等が挙げられる。 As the lower alcohol, ethanol, propanol, isopropanol, isobutyl alcohol, t-butyl alcohol and the like can be mentioned.
以下、試験例と実施例をもって本発明をさらに詳しく説明する。本発明は、以下の試験例や実施例によって何ら限定されるものではない。なお、以下の試験例を含め、本発明の全説明において、配合割合は全て質量%である。 Hereinafter, the present invention will be described in more detail by way of test examples and examples. The present invention is not limited at all by the following test examples and examples. In the entire description of the present invention including the following test examples, the blending ratios are all in mass%.
実施例に先立ち、各実施例で採用した評価法を説明する。 Prior to the examples, the evaluation method adopted in each example will be described.
(1)経時変色抑制評価(目視観察)
40℃で10ヶ月保存したときのサンプルの外観変化(変色)を下記基準に従って2段階で評価した。
(1) Time-lapse color change evaluation (visual observation)
The appearance change (color change) of the sample when stored at 40 ° C. for 10 months was evaluated in two steps according to the following criteria.
<目視評価基準>
○:目視による外観の変化(変色)が認められない
×:目視による外観の変化(変色)が認められる
<Visual evaluation criteria>
○: No change in appearance (discoloration) by visual observation is observed x: A change in appearance (discoloration) by visual observation is observed
(2)経時変色抑制評価(色差測定)
40℃で6ヶ月保存したときのサンプルの外観変化(変色)を色差計(コニカミノルタ社製CR−400)のΔb(経時保存後のb値−経時保存前のb値)により、下記基準に従
って4段階で評価した。
(2) Time-lapse color change evaluation (color difference measurement)
The appearance change (color change) of the sample when stored at 40 ° C. for 6 months is determined by Δb (b value after storage over time-b value before storage over time) of the color difference meter (CR-400 manufactured by Konica Minolta) according to the following criteria It evaluated in four steps.
<色差評価基準>
◎:Δbが1.5未満
○:Δbが1.0以上3.0未満
×:Δbが3.0以上5.0未満
××:Δbが5.0以上
<Color difference evaluation criteria>
:: Δb is less than 1.5 ○: Δb is 1.0 or more and less than 3.0 ×: Δb is 3.0 or more and less than 5.0 ××: Δb is 5.0 or more
実施例1〜6、比較例1〜2
表1に示す組成の化粧料を常法に準じて調製し、得られた化粧料について下記評価を行い、その結果を表1に併せて示す。
Examples 1 to 6, Comparative Examples 1 to 2
The cosmetic of the composition shown in Table 1 is prepared according to a conventional method, the obtained cosmetic is evaluated as follows, and the results are shown in Table 1.
表1より明らかなように、本発明の成分を用いた実施例1〜6の化粧料は比較例1〜2の組成物に比べて優れた性能を見出した。 As apparent from Table 1, the cosmetics of Examples 1 to 6 using the component of the present invention found superior performance as compared with the compositions of Comparative Examples 1 and 2.
以下、本発明化粧料のその他の処方例を実施例7、8、9、10として挙げる(以下、質量%を単に「%」と記す。)。なお、これらの実施例の化粧料についても、上記の長期経時変色抑制評価を実施した。 Hereinafter, other formulation examples of the cosmetic of the present invention will be listed as Examples 7, 8, 9 and 10 (hereinafter, mass% will be simply referred to as “%”). In addition, the above-mentioned long-term time-lapse color change suppression evaluation was implemented also about the cosmetics of these Examples.
(実施例7 乳液)
成分名 配合量(質量%)
(1)アスコルビン酸グルコシド 1.0
(2)水酸化カリウム 0.2
(3)精製水 3.0
(4)葉酸 0.001
(5)精製水 1.0
(6)ステアリン酸 1.0
(7)モノステアリン酸グリセリル 1.0
(8)セタノール 1.0
(9)コレステロール 0.5
(10)流動パラフィン 1.0
(11)メチルポリシロキサン 1.0
(12)スクワラン 1.0
(13)天然ビタミンE 0.01
(14)ビタミンA油 0.1
(15)水素添加大豆レシチン 0.1
(16)アシルグルタミン酸塩 0.5
(17)キサンタンガム 0.5
(18)グリセリン 2.0
(19)ジプロピレングリコール 3.0
(20)水酸化カリウム 0.002
(21)エデト酸二ナトリウム 0.01
(22)メチルパラベン 0.1
(23)フェノキシエタノール 0.04
(24)精製水 81.914
(25)ローヤルゼリーエキス 0.001
(26)キュウリ果実エキス 0.001
(27)アルテアエキス 0.001
(28)セージエキス 0.001
(29)ウイキョウエキス 0.001
(30)ブドウ葉エキス 0.001
(31)ローズマリー葉エキス 0.001
(32)チャ葉エキス 0.001
(33)ビルベリー果実エキス 0.001
(34)イタドリ根エキス 0.001
(35)サトウキビエキス 0.001
(36)レモン果実エキス 0.001
(37)オレンジ果実エキス 0.001
(38)ダイズ種子エキス 0.001
(39)カミツレ花エキス 0.001
(40)ヤグルマギク花エキス 0.001
(41)アルニカ花エキス 0.001
(42)ローマカミツレ花エキス 0.001
(43)フユボダイジュ花エキス 0.001
(44)トウキンセンカ花エキス 0.001
(45)ローズ水 0.001
(46)ハマメリス葉エキス 0.001
(47)ホップエキス 0.001
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
計 100.000
Example 7 Latex
Component name Compounding amount (mass%)
(1) Ascorbic acid glucoside 1.0
(2) Potassium hydroxide 0.2
(3) Purified water 3.0
(4) Folic acid 0.001
(5) Purified water 1.0
(6) Stearic acid 1.0
(7) Glyceryl monostearate 1.0
(8) Setanol 1.0
(9) cholesterol 0.5
(10) Liquid paraffin 1.0
(11) Methylpolysiloxane 1.0
(12) Squaran 1.0
(13) Natural vitamin E 0.01
(14) Vitamin A oil 0.1
(15) Hydrogenated soybean lecithin 0.1
(16) Acyl glutamate salt 0.5
(17) Xanthan gum 0.5
(18) Glycerin 2.0
(19) Dipropylene glycol 3.0
(20) Potassium hydroxide 0.002
(21) Edetate disodium 0.01
(22) Methyl paraben 0.1
(23) Phenoxyethanol 0.04
(24) Purified water 81.914
(25) Royal jelly extract 0.001
(26) cucumber fruit extract 0.001
(27) Altea extract 0.001
(28) Sage extract 0.001
(29) fennel extract 0.001
(30) Grape leaf extract 0.001
(31) Rosemary leaf extract 0.001
(32) Tea leaf extract 0.001
(33) Bilberry fruit extract 0.001
(34) Itabori root extract 0.001
(35) Sugar cane extract 0.001
(36) Lemon fruit extract 0.001
(37) Orange fruit extract 0.001
(38) Soybean seed extract 0.001
(39) Chamomile flower extract 0.001
(40) Cornflower Flower Extract 0.001
(41) Arnica flower extract 0.001
(42) Roman chamomile flower extract 0.001
(43) Fuyudaidai Flower Extract 0.001
(44) Tokinsenka Flower Extract 0.001
(45) Rose water 0.001
(46) Hamamelis leaf extract 0.001
(47) Hop extract 0.001
-------------------------
A total of 100.000
(調製方法)
1.成分(6)〜(15)を80℃にて、混合、溶解する(a)。
2.成分(16)〜(24)を80℃にて、混合、溶解する(b)。
3.(a)に(b)を添加して混合・攪拌・分散した。次いで、攪拌しながら50℃まで冷却し、成分(1)〜(3)及び成分(4)〜(5)及び成分(25)〜(47)を室温で混合しておいたものを加え分散、室温まで冷却し、乳液を得た。
(Preparation method)
1. Ingredients (6) to (15) are mixed and dissolved at 80 ° C (a).
2. Ingredients (16) to (24) are mixed and dissolved at 80 ° C. (b).
3. (B) was added to (a) and mixed, stirred and dispersed. Then, it is cooled to 50 ° C. with stirring, and components (1) to (3), components (4) to (5) and components (25) to (47) are mixed at room temperature and dispersed, The mixture was cooled to room temperature to obtain an emulsion.
(実施例8 クリーム)
成分名 配合量(質量%)
(1)アスコルビン酸グルコシド 2.0
(2)水酸化カリウム 0.4
(3)精製水 5.0
(4)葉酸 0.001
(5)精製水 1.0
(6)ステアリン酸 1.0
(7)モノステアリン酸グリセリル 2.0
(8)ベヘニルアルコール 1.5
(9)コレステロール 0.2
(10)流動パラフィン 2.0
(11)メチルポリシロキサン 1.0
(12)スクワラン 2.0
(13)トリ(カプリル酸/カプリン酸)グリセリル 2.0
(14)ミリスチン酸オクチルドデシル 2.0
(15)シクロメチコン 2.0
(16)2−エチルヘキサン酸セチル 2.0
(17)ダイマージリノール酸(フィトステリル/イソステアリル
/セチル/ステアリル/ベヘニル) 0.5
(18)ラウロイルグルタミン酸ジ(フィトステリル
/オクチルドデシル) 0.5
(19)ニコチン酸dl−α−トコフェロール 0.1
(20)水素添加大豆レシチン 0.3
(21)パルミチン酸レチノール 0.001
(22)フィトステロール 0.1
(23)セラミド3 0.0001
(24)アシルグルタミン酸塩 1.0
(25)キサンタンガム 0.1
(26)カルボキシビニルポリマー 0.2
(27)(アクリル酸/アクリル酸アルキル
(C10−30))コポリマー 0.1
(28)グリセリン 2.0
(29)ジプロピレングリコール 3.0
(30)ソルビトール 1.0
(31)マルチトール 1.0
(32)1,3−プロパンジオール 1.0
(33)1,3−ブチレングリコール 2.0
(34)トリプロピレングリコール 1.0
(35)ポリオキシエチレンメチルグルコシド 1.0
(36)PEG4000 1.0
(37)シクロヘキサンジカルボン酸
ビスエトキシジグリコール 0.1
(38)水酸化カリウム 0.25
(39)エデト酸二ナトリウム 0.02
(40)グリチルリチン酸ジカリウム 0.1
(41)フェノキシエタノール 0.3
(42)メチルパラベン 0.15
(43)精製水 54.3439
(44)ホップエキス 0.1
(45)ローヤルゼリーエキス 0.01
(46)ダイズエキス 0.1
(47)オウゴンエキス 0.01
(48)ユズエキス 0.01
(49)チャエキス 0.1
(50)トウキエキス 0.01
(51)レモンエキス 0.01
(52)ハトムギエキス 0.01
(53)ハス種子発酵液 0.1
(54)ウーロン茶エキス 0.01
(55)シャクヤクエキス 0.01
(56)セージエキス 0.1
(57)ブドウ葉エキス 0.01
(58)ヨクイニンエキス 0.1
(59)甘草抽出末 0.001
(60)グレープフルーツエキス 0.001
(61)シルクエキス 0.01
(62)真珠エキス 0.001
(63)コメヌカエキス 0.001
(64)カミツレエキス 0.01
(65)水溶性コラーゲン 0.01
(66)ヒアルロン酸Na 0.01
(67)SIMULGEL EG 1.0
(68)SEPIPLUS 265 1.0
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
計 100.000
Example 8 Cream
Component name Compounding amount (mass%)
(1) Ascorbic acid glucoside 2.0
(2) Potassium hydroxide 0.4
(3) Purified water 5.0
(4) Folic acid 0.001
(5) Purified water 1.0
(6) Stearic acid 1.0
(7) Glyceryl monostearate 2.0
(8) Behenyl alcohol 1.5
(9) cholesterol 0.2
(10) Liquid paraffin 2.0
(11) Methylpolysiloxane 1.0
(12) Squaran 2.0
(13) Tri (caprylic acid / capric acid) glyceryl 2.0
(14) Octyldodecyl myristate 2.0
(15) Cyclomethicone 2.0
(16) cetyl 2-ethylhexanoate 2.0
(17) dimer dilinoleic acid (phytosteryl / isostearyl
/ Cetyl / stearyl / behenyl) 0.5
(18) lauroyl glutamic acid di (phytosteryl
/ Octyl dodecyl) 0.5
(19) Nicotinic acid dl-α-tocopherol 0.1
(20) Hydrogenated soybean lecithin 0.3
(21) Retinol palmitate 0.001
(22) Phytosterol 0.1
(23) Ceramide 3 0.0001
(24) Acyl glutamate 1.0
(25) Xanthan gum 0.1
(26) Carboxy vinyl polymer 0.2
(27) (acrylic acid / alkyl acrylate)
(C10-30)) Copolymer 0.1
(28) Glycerin 2.0
(29) Dipropylene glycol 3.0
(30) Sorbitol 1.0
(31) maltitol 1.0
(32) 1,3-propanediol 1.0
(33) 1,3-butylene glycol 2.0
(34) Tripropylene glycol 1.0
(35) Polyoxyethylene methyl glucoside 1.0
(36) PEG 4000 1.0
(37) cyclohexanedicarboxylic acid
Bisethoxy diglycol 0.1
(38) Potassium hydroxide 0.25
(39) Edetic acid disodium 0.02
(40) dipotassium glycyrrhizinate 0.1
(41) Phenoxyethanol 0.3
(42) Methyl paraben 0.15
(43) Purified water 54. 3439
(44) Hop extract 0.1
(45) Royal jelly extract 0.01
(46) Soybean extract 0.1
(47) Ougon extract 0.01
(48) Yuzu extract 0.01
(49) Tea extract 0.1
(50) Touki extract 0.01
(51) Lemon extract 0.01
(52) Hatomigi extract 0.01
(53) Lotus seed fermented liquid 0.1
(54) Oolong tea extract 0.01
(55) Peony extract 0.01
(56) Sage extract 0.1
(57) Grape leaf extract 0.01
(58) Yoquinin extract 0.1
(59) Licorice extract end 0.001
(60) Grapefruit Extract 0.001
(61) Silk extract 0.01
(62) Pearl extract 0.001
(63) rice bran extract 0.001
(64) Chamomile extract 0.01
(65) water soluble collagen 0.01
(66) Hyaluronic acid Na 0.01
(67) SIMULGEL EG 1.0
(68) SEPI PLUS 265 1.0
-------------------------
A total of 100.000
(調製方法)
1.成分(6)〜(23)を80℃にて、混合、溶解する(a)。
2.成分(24)〜(43)を70℃にて、混合、溶解する(b)。
3.(a)に(b)を添加して混合・攪拌・分散した。次いで、攪拌しながら50℃まで冷却し、成分(1)〜(3)及び成分(4)〜(5)及び成分(44)〜(66)及び成分(67)〜(68)を室温で混合しておいたものを加え分散、室温まで冷却し、クリー
ムを得た。
(Preparation method)
1. Ingredients (6) to (23) are mixed and dissolved at 80 ° C (a).
2. Ingredients (24) to (43) are mixed and dissolved at 70 ° C. (b).
3. (B) was added to (a) and mixed, stirred and dispersed. Subsequently, it cools to 50 degreeC, stirring, and mixes component (1)-(3), component (4)-(5), component (44)-(66), and component (67)-(68) at room temperature The solution was added and dispersed, cooled to room temperature to obtain a cream.
(実施例9 化粧水)
成分名 配合量(質量%)
(1)エタノール 10.0
(2)POE(60)硬化ヒマシ油 0.5
(3)酢酸dl−α−トコフェロール 0.01
(4)アスコルビン酸グルコシド 2.0
(5)1,3−ブチレングリコール 2.0
(6)ジプロピレングリコール 3.0
(7)ポリエチレングリコール1500 1.0
(8)リン酸塩 0.02
(9)フェノキシエタノール 0.2
(10)エデト酸四ナトリウム 0.01
(11)葉酸 0.0001
(12)水酸化カリウム 0.001
(13)精製水 81.2589
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
計 100.000
Example 9 Lotion
Component name Compounding amount (mass%)
(1) Ethanol 10.0
(2) POE (60) hydrogenated castor oil 0.5
(3) Acetic acid dl-α-tocopherol 0.01
(4) Ascorbic acid glucoside 2.0
(5) 1,3-butylene glycol 2.0
(6) Dipropylene glycol 3.0
(7) Polyethylene glycol 1500 1.0
(8) Phosphate 0.02
(9) Phenoxyethanol 0.2
(10) Edetate tetrasodium 0.01
(11) Folic acid 0.0001
(12) Potassium hydroxide 0.001
(13) Purified water 81.2589
-------------------------
A total of 100.000
(調製方法)
1.成分(1)〜(13)を混合、溶解、攪拌し、化粧水を得た。
(実施例10 サンスクリーン)
成分名 配合量(質量%)
(1)エタノール 9.0
(2)メトキシケイ皮酸オクチル 6.0
(3)POE・POP変性ジメチルポリシロキサン 1.5
(4)微粒子酸化チタン 3.0
(5)酸化亜鉛 5.0
(6)メチルシクロポリシロキサン 8.0
(7)ジメチルポリシロキサン 5.0
(8)アスコルビン酸グルコシド 0.1
(9)葉酸 0.01
(10)水酸化カリウム 0.001
(11)精製水 62.389
−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−−
計 100.000
(Preparation method)
1. Ingredients (1) to (13) were mixed, dissolved and stirred to obtain a lotion.
Example 10 Sun Screen
Component name Compounding amount (mass%)
(1) Ethanol 9.0
(2) Octyl methoxycinnamate 6.0
(3) POE / POP modified dimethylpolysiloxane 1.5
(4) Fine particle titanium oxide 3.0
(5) Zinc oxide 5.0
(6) Methyl cyclopolysiloxane 8.0
(7) Dimethylpolysiloxane 5.0
(8) ascorbic acid glucoside 0.1
(9) folic acid 0.01
(10) Potassium hydroxide 0.001
(11) Purified water 62.389
-------------------------
A total of 100.000
(調製方法)
1.成分(2)〜(7)を80℃にて、混合、溶解する(a)。
2.成分(8)〜(11)を室温にて、混合する(b)。
3.(a)に(b)を添加して攪拌し、冷却する(c)。
4.(c)に成分(1)を添加し、攪拌後、サンスクリーンを得た。
(Preparation method)
1. Ingredients (2) to (7) are mixed and dissolved at 80 ° C. (a).
2. Ingredients (8) to (11) are mixed at room temperature (b).
3. Add (b) to (a), stir and cool (c).
4. Component (1) was added to (c), and after stirring, a sunscreen was obtained.
各製法に基づき、実施例7〜10の化粧料を調製し、長期経時変色抑制評価を実施したところ、良好な結果を得た。 When the cosmetics of Examples 7-10 were prepared based on each manufacturing method and long-term time-lapse discoloration suppression evaluation was implemented, a favorable result was obtained.
Claims (4)
(a)アスコルビン酸グルコシド
(b)葉酸 A cosmetic comprising the following components (a) to (b).
(A) ascorbic acid glucoside (b) folic acid
(b)葉酸 A method of suppressing temporal discoloration of a cosmetic containing ascorbic acid glucoside by adding the following component (b) to a cosmetic containing ascorbic acid glucoside.
(B) folic acid
(b)葉酸
(c)トコフェロール及びその誘導体
The method of suppressing the temporal discoloration of cosmetics containing ascorbic acid glucoside by adding the following component (b) and (c) to cosmetics containing ascorbic acid glucoside.
(B) folic acid (c) tocopherol and its derivatives
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Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013203710A (en) * | 2012-03-29 | 2013-10-07 | Kose Corp | Folic acid blended product |
JP2017070271A (en) * | 2015-10-05 | 2017-04-13 | 有限会社ジェイエヌピー研究所 | Food product or supplement |
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2013203710A (en) * | 2012-03-29 | 2013-10-07 | Kose Corp | Folic acid blended product |
JP2017070271A (en) * | 2015-10-05 | 2017-04-13 | 有限会社ジェイエヌピー研究所 | Food product or supplement |
Non-Patent Citations (2)
Title |
---|
ACO HUD NORDIC, SWEDEN: "Smoothing Anti-Age Eye Cream", MINTEL GNPD [ONLINE], JPN6021029428, April 2015 (2015-04-01), ISSN: 0004751897 * |
LABORATOIRES FILORGA, FRANCE: "NCTF-Intensive Supreme Regenerating Serum", MINTEL GNPD [ONLINE], JPN6022014326, March 2017 (2017-03-01), ISSN: 0004751896 * |
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