JP2019055043A - Cortisol concentration estimation device, cortisol concentration estimation method, and program - Google Patents

Abstract

To estimate cortisol concentration noninvasively and simply.SOLUTION: A cortisol concentration estimation device 1 estimates cortisol concentration of a subject. The cortisol concentration estimation device 1 has a computing unit 23 that calculates a representative value of a heart rate-related index value in a predetermined time section, which is related to a heart rate of the subject measured for each time, and an estimation unit 24 that estimates cortisol concentration of the subject from the representative value so that the representative value and cortisol concentration have a positive correlation.SELECTED DRAWING: Figure 3

Description

  The present invention relates to a cortisol concentration estimation device, a cortisol concentration estimation method, and a program.

  Conventionally, it is known to measure cortisol concentration from body fluid such as blood, urine, saliva, etc. of a subject using a specialized analyzer. For example, Non-Patent Document 1 describes that the cortisol concentration is measured by a body fluid by an RIA (Radio Immuno Assay) method and an EIA method (Enzyme Immuno Assay) method. In addition, liquid chromatography tandem mass spectrometry is also known as a method for measuring cortisol concentration from body fluids. Non-Patent Document 2 describes that there is a negative correlation between the amount of parasympathetic nerve activity of a subject under a high stress level and the cortisol concentration measured from saliva.

Hershel Raff, 1 other, "Circadian rhythm of salivarycortisol, plasma cortisol, and plasma ACTH in end-stage renal disease", Endocrine Connections, October 2012, 2: 23-31 Kozo Yoshino, 3 others, “Correlation between bedtime salivary cortisol concentration and autonomic nervous system activity balance in young men”, Stress Science Research 2011, 26, 48-52

  When the RIA method and the EIA method as described above are used, it may take several days or more to measure the cortisol concentration and may not be accurately measured. Further, according to the liquid chromatography tandem mass spectrometry, the cortisol concentration is accurately measured, but it takes several days or more. In order to estimate the cortisol concentration based on the correlation with the heart rate, it is necessary to measure the heart rate after placing the subject in a specific state of high stress. In Non-Patent Document 2, it has not been confirmed that there is a correlation between heart rate and cortisol concentration in a state other than a high stress state or in a time zone other than before going to bed, and this is a future problem. Therefore, there is a problem that it is difficult to quickly and easily grasp the cortisol concentration in any time zone and in a state where there is no high stress by any of the above-described methods.

  An object of the present invention made in view of such circumstances is to provide a cortisol concentration estimation device, a cortisol concentration estimation method, and a program that can non-invasively and easily estimate the cortisol concentration.

  In order to solve the above problems, a cortisol concentration estimation device according to the present invention is a cortisol concentration estimation device that estimates the cortisol concentration of a subject in a resting state, and the heart rate measured at each time of the subject A calculation unit that calculates a representative value of a related heartbeat-related index value in a predetermined time interval, and the cortisol concentration of the subject is estimated from the representative value so that the representative value and the cortisol concentration have a positive correlation. And an estimation unit.

The cortisol concentration estimation device according to the present invention is a cortisol concentration estimation device that estimates the cortisol concentration of a subject in a resting state,
A calculation unit that acquires a representative value in a predetermined time interval of a heartbeat-related index value related to a heartbeat calculated at each time of the subject;
The cortisol concentration of the subject when the representative value is a second value larger than the first value than the estimated value of the subject's cortisol concentration when the representative value of the heart rate related index value is the first value Estimator for estimating the cortisol concentration of the subject, so that is a large value,
It is characterized by providing.

  The cortisol concentration estimation method according to the present invention is a cortisol concentration estimation method for estimating the cortisol concentration of a subject in a resting state, and is a heart rate related index related to the heart rate measured at each time of the subject Calculating a representative value in a predetermined time interval of the value, and estimating the cortisol concentration of the subject from the representative value so that the representative value and the cortisol concentration have a positive correlation. Features.

The cortisol concentration estimation method according to the present invention is a cortisol concentration estimation device that estimates the cortisol concentration of a subject in a resting state,
Obtaining a representative value in a predetermined time interval of a heart rate related index value related to a heart rate calculated for each time of the subject;
The cortisol concentration of the subject when the representative value is a second value larger than the first value than the estimated value of the subject's cortisol concentration when the representative value of the heart rate related index value is the first value Estimating the cortisol concentration of the subject so that is a large value;
It is characterized by including.

  The program according to the present invention causes a computer to function as the cortisol concentration estimation apparatus.

  According to the present invention, the cortisol concentration can be estimated non-invasively and easily.

It is a figure which shows an example of the time change of the heart rate calculated from the electrocardiogram. It is a figure which shows the correlation with the representative value of the heart rate at rest, and cortisol concentration. It is a block diagram which shows the structural example of the cortisol density | concentration estimation apparatus which concerns on the 1st Embodiment of this invention. It is a flowchart which shows an example of the cortisol density | concentration estimation method which concerns on the 1st Embodiment of this invention. It is a block diagram which shows the structural example of the cortisol density | concentration estimation apparatus which concerns on the 2nd Embodiment of this invention. It is a flowchart which shows an example of the cortisol density | concentration estimation method which concerns on the 2nd Embodiment of this invention.

  In describing the embodiment of the present invention, the correlation between the heart rate and cortisol concentration discovered by the inventors will be described first.

  In experiments conducted by the inventors, heart rate related index values related to the heart rate of 20 subjects in a resting state were measured. In this experiment, the heart rate related index value is the heart rate. The inventors also calculated a representative value of the heart rate related index value, that is, a representative value of the heart rate. The representative value is, for example, a value obtained by statistically calculating the heart rate measured within a predetermined time such as an average value or an intermediate value. A known electrocardiograph was used for measuring the heart rate. Here, “rest state” is used to mean “not performing a task”. In other words, it does not mean “absolute rest” in which the person does not lie down, but means that the task (task) has not been performed, in other words, “normal state”.

  The electrocardiograph measures the voltage between electrodes attached to the subject. The electrocardiograph calculates the heart rate based on the RR interval, which is the interval between one R wave and the R wave adjacent to the one R wave. Thereby, the electrocardiograph can measure the time change of the heart rate as shown in FIG.

  Moreover, in this experiment, when the heart rate related index value was measured as described above, saliva was collected from each of 20 subjects, and the cortisol concentration in the saliva was measured.

  FIG. 2 is a diagram showing the relationship between cortisol concentration and a representative value of heart rate. The vertical axis represents the cortisol concentration measured from the saliva of the subject. The horizontal axis is a representative value of heart rate. As shown in FIG. 2, it can be seen that the higher the representative value of the heart rate, the higher the cortisol concentration. Thus, the inventors have found that there is a positive correlation between the cortisol concentration and the representative value of the heart rate. In this experiment, unlike Non-Patent Document 2, the measurement is performed in the daytime, not in the pre-sleeping time zone. Also, the subject is not in a high stress state. That is, a positive correlation between the cortisol concentration and the heart rate-related index value for a subject in an arbitrary state (a state that is not a high stress state) in the daytime period, which has not been clarified in Non-Patent Document 2. It was observed. The representative value of the heart rate in this experiment was the average value of the heart rate in a predetermined time interval.

  The correlation function between the heart rate related index value and the cortisol concentration can be derived from the experimental results. The correlation function varies depending on the environment and conditions of the experiment, but an example is shown in Equation (1). In the formula (1), CORT is the cortisol concentration. HR is a representative value of heart rate. In the present invention, the cortisol concentration is calculated using the positive correlation or correlation function thus derived.

  CORT = 28.9 × HR-1035 Formula (1)

(First embodiment)
Hereinafter, a first embodiment of the present invention will be described in detail with reference to the drawings. FIG. 3 is a diagram illustrating a configuration example of the cortisol concentration estimation apparatus 1 according to the first embodiment. The cortisol concentration estimation device 1 is a device that estimates the cortisol concentration of a subject in a resting state, and as shown in FIG. 3, an input unit 21, a heart rate related index value storage unit 22, a calculation unit 23, A unit 24 and an output unit 25 are provided. Further, the cortisol concentration estimation device 1 receives information output from the measurement device 4. Further, the cortisol concentration estimation device 1 outputs information to the presentation device 5.

  The measuring device 4 measures the heart rate related index value of the subject who is in a resting state for a predetermined time interval, and outputs it to the cortisol concentration estimating device 1. The heart rate related index value is an index value related to the heart rate. The predetermined time interval is a time (for example, 60 seconds) in which the representative value of the heartbeat-related index value calculated by the calculation unit 23 is considered to effectively indicate the state of the subject. The representative value is a value obtained by statistically calculating a predetermined time interval such as an average value and an intermediate value, and a measured heartbeat-related index value. In the present embodiment, an example in which the heart rate related index value is a heart rate will be described. In this case, the measurement device 4 measures the heart rate and sequentially outputs the measured heart rate to the cortisol concentration estimation device 1.

  Each structure with which the cortisol concentration estimation apparatus 1 is provided is demonstrated in detail.

  The input unit 21 inputs a heartbeat-related index value for each time that is measured by the measuring device 4 for a predetermined time interval and sequentially output. Specifically, the input unit 21 inputs time series data of heart rate related index values. More specifically, the input unit 21 inputs time-series data of heart rate.

  The heartbeat-related index value storage unit 22 may include an arbitrary storage device such as a semiconductor storage device and a magnetic storage device, or may include a plurality of types of storage devices. The heartbeat-related index value storage unit 22 stores time-series data of heartbeat-related index values measured by the measurement device 4 for a predetermined time interval and input by the input unit 21. Specifically, the heart rate related index value storage unit 22 stores the heart rate related index value continuously measured in a predetermined time interval and the time when the heart rate related index value is measured in association with each other. The time may be an elapsed time from the start time.

  The computing unit 23 calculates a representative value of the heart rate related index value based on the time series data of the heart rate related index value in the predetermined time interval stored in the heart rate related index value storage unit 22.

  The estimation unit 24 estimates the cortisol concentration from the representative value of the heartbeat-related index value so that the predetermined representative value of the heartbeat-related index value and the cortisol concentration have a positive correlation. Specifically, when the representative value is calculated by the calculation unit 23, the estimating unit 24 is configured so that the estimated value of the cortisol concentration has a positive correlation with the representative value, that is, the larger the representative value, the higher the representative value. The cortisol concentration is estimated to indicate that the concentration estimate is large. Alternatively, the estimating unit 24 determines that the estimated value of the cortisol concentration when the representative value is the second value larger than the first value is larger than the estimated value of the cortisol concentration when the representative value is the first value. As such, cortisol concentration is estimated. For example, the estimation unit 24 estimates the cortisol concentration based on a positive correlation function related to a representative value of a predetermined heart rate related index value. As an example of the positive correlation function, the cortisol concentration is estimated using the positive correlation function represented by the above formula (1).

  The output unit 25 outputs the cortisol concentration estimated by the estimation unit 24 to the presentation device 5.

  The presentation device 5 presents information indicating the cortisol concentration estimated by the estimation unit 24 and output by the output unit 25. For example, the presentation device 5 may display the cortisol concentration on the display, or may display an arbitrary index corresponding to the cortisol concentration on the display. Moreover, the presentation apparatus 5 may output the audio | voice which shows cortisol density | concentration.

  Next, a cortisol concentration estimation method by the cortisol concentration estimation apparatus 1 will be described with reference to FIG. FIG. 4 is a flowchart showing an example of a cortisol concentration estimation method.

  First, the heartbeat-related index value for each predetermined time interval and time measured by the measuring device 4 is input by the input unit 21 (step S41).

  Next, the heartbeat-related index value storage unit 22 stores the heartbeat-related index value for each time input in step S41 (step S42).

  Next, the calculation unit 23 calculates a representative value of the heart rate related index value in a predetermined time interval from the heart rate related index value for each time stored in the heart rate related index value storage unit 22 (step S43). An example of the representative value is an average value of the heartbeat-related index values in the predetermined time interval, but is not limited thereto, and any value that represents the heartbeat-related index value in the predetermined time interval may be used.

  Next, the estimation unit 24 estimates the cortisol concentration so as to have a positive correlation with the representative value based on the representative value calculated in step S43 (step S44). For example, the cortisol concentration is estimated using a positive correlation related to a predetermined representative value or a positive correlation function related to the representative value. Assuming that the cortisol concentration estimated by the estimation unit 24 when the representative value is the first value is the first cortisol concentration, the cortisol concentration estimated by the estimation unit when the representative value is the second value larger than the first value. Is estimated by the estimation unit 24 so that the second value is larger than the first cortisol concentration.

  Next, the output unit 25 outputs the cortisol concentration estimated in step S44 to the presentation device 5 (step S45). The presentation device 5 can present the cortisol concentration output from the output unit 25.

  Note that a computer can be suitably used to function as the above-described cortisol concentration estimation apparatus 1, and such a computer stores a program describing processing contents for realizing each function of the cortisol concentration estimation apparatus 1. This can be realized by storing the program in a database and reading and executing the program by the CPU of the computer.

  The program may be recorded on a computer readable medium. If a computer-readable medium is used, it can be installed on a computer. Here, the computer-readable medium on which the program is recorded may be a non-transitory recording medium. The non-transitory recording medium is not particularly limited, but may be a recording medium such as a CD-ROM or a DVD-ROM.

  As described above, according to the first embodiment, the cortisol concentration estimation device 1 is based on the discovery of the natural law that a positive correlation is established between the representative value of the heart rate-related index value and the cortisol concentration. The cortisol concentration of the subject is estimated from the representative value calculated by the calculation unit 23. Therefore, compared with the case where it measures using a bodily fluid like the past, the cortisol concentration estimation apparatus 1 can estimate a cortisol concentration rapidly. In addition, since the heartbeat-related index value is measured noninvasively, the cortisol concentration estimation apparatus 1 can easily estimate the cortisol concentration.

(Second Embodiment)
Hereinafter, a second embodiment of the present invention will be described in detail with reference to the drawings. In the present embodiment, it is determined whether or not to propose meditation to the subject based on the “cortisol concentration” estimated by the same method as in the first embodiment.

It is known that human cortisol levels change during the day. Moreover, when there is little change of the cortisol density | concentration in one day, it is known that there exists a possibility of being in a depression state (reference document 1). Furthermore, the inventors' research has found that the effects of human meditation differ on human effects. Specifically, parasympathetic nerve activity is activated by intensive meditation, and sympathetic nerve activity tends to be activated by insight meditation. The research was published in "Mindfulness Study: Effects of Intensive Meditation and Insight Meditation on Autonomic Nervous System and Endocrine System" at the 40th Annual Meeting of the Japan Neuroscience Society.
(Reference 1) Ma-Li Wong et al .: Pronounced and sustained central hypernoradrenergic function in major depression with melancholic features: Relation to hypercortisolism and corticotropin-releasing hormone, Medical Sciences Vol. 97, No.1, pp.325-330 (2000).

  When these findings are combined, there is a possibility of depression when diurnal fluctuations in cortisol levels are small, and in this case, insight meditation that has the effect of activating the sympathetic nerves can improve depression. Be expected. In the present embodiment, based on such knowledge, it is determined whether or not to propose meditation suitable for the mental state of the subject.

  FIG. 5 shows a configuration example of the cortisol concentration estimation apparatus 2 according to the second embodiment. As shown in FIG. 5, the cortisol concentration estimation device 2 includes a cortisol concentration estimation unit 20, an output unit 25, a cortisol concentration storage unit 26, and a determination unit 27. Similar to the cortisol concentration estimation apparatus 1 of the first embodiment, the cortisol concentration estimation unit 20 includes an input unit 21, a heartbeat-related index value storage unit 22, a calculation unit 23, and an estimation unit 24. The same constituent blocks as those in the first embodiment are denoted by the same reference numerals, and description thereof will be omitted as appropriate.

  The measuring device 4 measures a heart rate related index value at different times of the day.

  The cortisol concentration estimation unit 20 estimates the cortisol concentration of the subject for each heart rate related index value measured by the measurement device 4 at different times. The detailed method of estimation by the cortisol concentration estimation unit 20 is the same as the estimation method by the cortisol concentration estimation apparatus 1 of the first embodiment.

  The cortisol concentration storage unit 26 stores the cortisol concentration estimated by the cortisol concentration estimation unit 20. Specifically, the cortisol concentration storage unit 26 stores the cortisol concentration in association with the time when the heartbeat-related index value used for estimating the cortisol concentration is measured. The time may be anything as long as it can identify the time interval in which the representative value of the heart rate related index value is calculated. The time may be, for example, the time at which the measurement was started in the time interval for which the representative value of the heart rate related index value was obtained, or the measurement was completed in the time interval for which the representative value of the heart rate related index value was obtained. It may be a time. In this embodiment, the cortisol concentration estimation part 10 estimates a cortisol concentration from the heart rate related index value measured in the said time interval about several different time intervals. The cortisol concentration storage unit 26 stores a plurality of estimated cortisol concentrations.

  The determination unit 27 determines whether or not to propose meditation based on the amount of change in cortisol concentration at a plurality of different times (time intervals) estimated by the estimation unit 24. In general, meditation includes intensive meditation and insight meditation. Intensive meditation is a meditation that focuses on a part of the body (for example, the entrance to the nose), and insight meditation is a meditation that pays attention to any part of the body.

  Specifically, the determination unit 27 proposes meditation based on the index based on the cortisol concentration estimated for a plurality of different time intervals in a day stored in the cortisol concentration storage unit 26. Determine whether or not. For example, by calculating the difference (change amount) of cortisol concentration for adjacent time intervals to obtain a series of change amounts, it is determined that an insight meditation is proposed if each value of the change amount series is less than a predetermined threshold value. Otherwise, it is determined not to propose meditation. That each value of the series of the amount of change in the cortisol concentration is less than a predetermined threshold indicates that the amount of fluctuation in the cortisol concentration during the day is small, that is, the daily fluctuation in the cortisol concentration is small. As described above, when the daily fluctuation of the cortisol concentration is small, there is a possibility of depression, and the improvement is expected by the insight meditation. Therefore, the insight meditation is proposed by the determination unit 27.

  When it is determined by the determination unit 27 that the insight meditation is proposed, the output unit 25 outputs meditation proposal information for proposing meditation to the target person to the presentation device 5. The meditation proposal information is, for example, information such as “please perform insight meditation”, instruction voices and images for promoting insight meditation, and the like. Alternatively, when the determination unit 27 determines that the insight meditation is proposed, the output unit 25 outputs the cortisol concentration estimated by the cortisol concentration estimation unit 20 to the presentation device 5 in addition to the meditation proposal information, and performs the insight meditation. If it is determined not to be proposed, only the cortisol concentration estimated by the cortisol concentration estimation unit 20 may be output to the presentation device 5.

  When the meditation proposal information is output by the output unit 25, the presentation device 5 presents the meditation proposal information to the target person. For example, the presentation device 5 can present meditation proposal information by outputting sound. For example, the presentation apparatus 5 can present meditation proposal information by display on a display. Or you may display the cortisol density | concentration output from the output part 25 on a display in time series, and may display on a display with the visual effect which calls attention when displaying the cortisol density | concentration corresponding to meditation proposal information. For example, it may be a visual effect of changing the background color of the display screen or blinking, or a visual effect of displaying a text message such as “Please do insight meditation”.

  Subsequently, an example of a cortisol concentration estimation method by the cortisol concentration estimation apparatus 2 will be described with reference to FIG. FIG. 6 is a flowchart showing an example of a cortisol concentration estimation method.

  First, the cortisol concentration estimation unit 20 estimates the cortisol concentration of the subject (step S51). Details of the processing by the cortisol concentration estimation unit 20 in step S51 are the same as the processing of the cortisol concentration estimation apparatus 1 in the first embodiment.

  Next, the cortisol concentration estimated in step S51 is stored in the cortisol concentration storage unit 26 (step S52).

  Next, the determination unit 27 determines whether or not the cortisol concentration for the subject for a predetermined time is already stored in the cortisol concentration storage unit 26 (step S53).

  If it is determined in step S53 that the cortisol concentration for the subject is not stored in the cortisol concentration storage unit 26, the process returns to step S51 to estimate the cortisol concentration for a new time.

  On the other hand, when it is determined in step S53 that the cortisol concentration for the subject for a predetermined time is stored in the cortisol concentration storage unit 26, the determination unit 27 determines the difference in cortisol concentration for adjacent times ( Change amount) is calculated to calculate a sequence of change amounts (step S54).

  Next, the determination unit 27 determines whether or not each of the change amounts calculated in step S54 is less than a threshold value (step S55).

  In step S55, when there is a change amount equal to or greater than the threshold value among the change amounts, the cortisol concentration estimation apparatus 2 ends the process.

  On the other hand, if it is determined in step S55 that all the changes are less than the threshold value, the output unit 25 outputs meditation proposal information to the presentation device 5 (step S56). In addition, the presentation apparatus 5 can present the meditation proposal information output from the output unit 25.

  It should be noted that a computer can be suitably used to function as the above-described cortisol concentration estimation device 2, and such a computer can store a program describing processing contents for realizing each function of the cortisol concentration estimation device 2. This can be realized by storing the program in a database and reading and executing the program by the CPU of the computer.

  The program may be recorded on a computer readable medium. If a computer-readable medium is used, it can be installed on a computer. Here, the computer-readable medium on which the program is recorded may be a non-transitory recording medium. The non-transitory recording medium is not particularly limited, but may be a recording medium such as a CD-ROM or a DVD-ROM.

  As described above, according to the second embodiment, the cortisol concentration estimation device 1 determines whether to propose meditation to the subject based on the cortisol concentration, and the presentation device 5 provides the meditation proposal information. Present. Therefore, the cortisol concentration estimation device 1 promptly proposes meditation as compared with the conventional case where the subject's depression is determined based on the cortisol concentration measured using body fluids and meditation is proposed. Can do. Accordingly, the subject can meditate early in order to improve the depression. In addition, since the heartbeat-related index value is measured non-invasively, the cortisol concentration estimation device 2 can easily estimate the cortisol concentration and easily suggest meditation accordingly.

  In the first embodiment, the cortisol concentration estimation device 1 may include the measurement device 4 as a measurement unit. In this case, the measurement unit of the cortisol concentration estimation apparatus 1 measures the heart rate of the subject. Similarly, in the second embodiment, the cortisol concentration estimation unit 20 may include the measurement device 4 as a measurement unit.

  Moreover, in 1st Embodiment, the cortisol density | concentration estimation apparatus 1 may be provided with the presentation apparatus 5 as a presentation part. In this case, the presentation unit presents the cortisol concentration. Similarly, in 2nd Embodiment, the cortisol concentration estimation apparatus 1 may be provided with the presentation apparatus 5 as a presentation part. In this case, the presentation unit presents meditation proposal information.

  Although the above embodiment has been described as a representative example, it will be apparent to those skilled in the art that many changes and substitutions can be made within the spirit and scope of the invention. Therefore, the present invention should not be construed as being limited by the above-described embodiments, and various modifications and changes can be made without departing from the scope of the claims.

DESCRIPTION OF SYMBOLS 1, 2 Cortisol density | concentration estimation apparatus 4 Measuring apparatus 5 Presentation apparatus 20 Cortisol density | concentration estimation part 21 Input part 22 Heart rate related index value memory | storage part 23 Calculation part 24 Estimation part 25 Output part 26 Cortisol density | concentration memory | storage part 27 Determination part

Claims (8)

A cortisol concentration estimation device for estimating a cortisol concentration of a subject,
A calculation unit that calculates a representative value in a predetermined time interval of a heartbeat-related index value related to a heartbeat measured at each time of the subject;
An estimation unit that estimates the cortisol concentration of the subject from the representative value so that the representative value and the cortisol concentration have a positive correlation;
A cortisol concentration estimation device comprising: A cortisol concentration estimation device for estimating a cortisol concentration of a subject,
A calculation unit that calculates a representative value in a predetermined time interval of a heartbeat-related index value related to a heartbeat calculated for each time of the subject;
The cortisol concentration of the subject when the representative value is a second value larger than the first value than the estimated value of the subject's cortisol concentration when the representative value of the heart rate related index value is the first value Estimator for estimating the cortisol concentration of the subject, so that is a large value,
A cortisol concentration estimation device comprising: A determination unit for determining whether to propose meditation to the subject based on the cortisol concentration for a plurality of different predetermined time intervals estimated by the estimation unit;
The cortisol concentration estimation apparatus according to claim 1, further comprising:   The determination unit determines that the meditation is proposed when a change amount of the cortisol concentration estimated for each of the plurality of different predetermined time intervals is less than a threshold value over the plurality of different time intervals. The cortisol concentration estimation apparatus according to claim 3.   The determination unit determines to propose the meditation when the amount of change in each adjacent time interval of the cortisol concentration estimated for each of the plurality of different predetermined time intervals is less than a predetermined threshold value. The cortisol concentration estimation apparatus according to claim 3, wherein: A cortisol concentration estimation method for estimating cortisol concentration of a subject,
Calculating a representative value in a predetermined time interval of a heartbeat-related index value related to a heartbeat measured at each time of the subject;
Estimating the cortisol concentration of the subject from the representative value such that the representative value and the cortisol concentration have a positive correlation;
A method for estimating cortisol concentration. A cortisol concentration estimation device for estimating a cortisol concentration of a subject,
Obtaining a representative value in a predetermined time interval of a heart rate related index value related to a heart rate calculated for each time of the subject;
The cortisol concentration of the subject when the representative value is a second value larger than the first value than the estimated value of the subject's cortisol concentration when the representative value of the heart rate related index value is the first value Estimating the cortisol concentration of the subject so that is a large value;
A method for estimating cortisol concentration.   The program for functioning a computer as a cortisol density | concentration estimation apparatus as described in any one of Claim 1 to 5.

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