JP2018533992A5 - - Google Patents

Claims (14)

A system suitable for heat treating living tissue,
Characterized by a pulse energy source (16) having energy parameters including wavelength or frequency, power, and a duty cycle of 10% or less, said pulse energy source (16) being targeted tissue for a total pulse train duration of less than 1 second While applying at least the pulse energy source (16) to (18), the target tissue temperature is increased from 6 ° C. to 11 ° C., and the increase in the average tissue temperature over 6 minutes permanently maintained so as not to below Celsius 6 ° C corruption, system. The system of claim 1, wherein the pulse energy source (16) stimulates activation of heat shock proteins in the target tissue . The system of claim 1 or 2, wherein the increase in average temperature of the target tissue (18) is maintained at approximately 1 ° C or less for 6 minutes or less . The system of claim 1 , wherein the energy parameter of the pulse energy source (16) is selected such that approximately 20-40 joules of energy is absorbed into each cubic centimeter of target tissue. The system of claim 1, comprising a device (14) insertable into a body cavity for applying a pulsed energy source to a target tissue. The system of claim 1, wherein the pulsed energy source (16) is applied to a blood supply near the target tissue (18). The system of claim 1 , wherein the pulse energy source (16) comprises laser light, microwave, radio frequency, or ultrasound. The pulse energy source (16) has a radio frequency of approximately 3-6 megahertz (MHz), a duty cycle of approximately 2.5% to 5%, and a pulse train duration of approximately 0.2-0.4 seconds. look including the time, preferably generated by the device having a coil radius and approximately 13 to 57 amps number of approximately 2 to 6 mm, according to any of claims 1, 2 or 4-7, system. The pulse energy source (16) includes a microwave having a frequency of approximately 10-20 gigahertz (GHz), a pulse train duration of approximately 0.2-0.6 seconds, and a duty cycle of approximately 2% -5%. The system according to claim 1, 2, or 4. The system of claim 9, wherein the microwave has an average power of approximately 8-52 watts. The pulse energy source (16) comprises a pulsed light beam (30) having a wavelength of approximately 530 nm to 1300 nm, a duty cycle of less than 10%, and a pulse train duration of approximately 0.1 to 0.6 seconds. 2 or 4-7. The system of claim 11, wherein the pulsed light beam (30) has a wavelength of 800 nm to 1000 nm and a power of approximately 0.5 to 74 watts. The pulse energy source (16) includes pulsed ultrasound (80) having a frequency of approximately 1-5 MHz, a train duration of approximately 0.1-0.5 seconds, and a duty cycle of approximately 2% -10%. A system according to any one of claims 1, 2, or 4-7. 14. The system of claim 13, wherein the pulsed ultrasound (80) has a power of approximately 0.46 to 28.6 watts.