JP2018525413A - ユーイングファミリー腫瘍を治療する組成物及び方法 - Google Patents

ユーイングファミリー腫瘍を治療する組成物及び方法 Download PDF

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JP2018525413A
JP2018525413A JP2018510098A JP2018510098A JP2018525413A JP 2018525413 A JP2018525413 A JP 2018525413A JP 2018510098 A JP2018510098 A JP 2018510098A JP 2018510098 A JP2018510098 A JP 2018510098A JP 2018525413 A JP2018525413 A JP 2018525413A
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tyrosine kinase
kinase inhibitor
biguanide compound
imatinib
metformin
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JP2018525413A5 (https=
Inventor
ホン チャオ
ホン チャオ
ステファン ティー．シー． ウォン
ステファン ティー．シー． ウォン
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ザ メソディスト ホスピタル
ザ メソディスト ホスピタル
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Hospice & Palliative Care (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018510098A 2015-08-24 2016-08-22 ユーイングファミリー腫瘍を治療する組成物及び方法 Pending JP2018525413A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562209197P 2015-08-24 2015-08-24
US62/209,197 2015-08-24
US201562209645P 2015-08-25 2015-08-25
US62/209,645 2015-08-25
PCT/US2016/047984 WO2017035057A1 (en) 2015-08-24 2016-08-22 Compositions and methods for treating ewing family tumors

Publications (2)

Publication Number Publication Date
JP2018525413A true JP2018525413A (ja) 2018-09-06
JP2018525413A5 JP2018525413A5 (https=) 2019-10-03

Family

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Family Applications (1)

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JP2018510098A Pending JP2018525413A (ja) 2015-08-24 2016-08-22 ユーイングファミリー腫瘍を治療する組成物及び方法

Country Status (7)

Country Link
US (1) US10765675B2 (https=)
EP (1) EP3340978A4 (https=)
JP (1) JP2018525413A (https=)
CN (1) CN106714795A (https=)
CA (1) CA2995642A1 (https=)
TW (1) TW201717926A (https=)
WO (1) WO2017035057A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108034726B (zh) * 2018-01-18 2021-07-30 四川大学华西医院 检测mlh1表达水平的试剂在制备肿瘤靶向药敏感性检测试剂盒中的用途
WO2022093789A1 (en) * 2020-10-27 2022-05-05 Dana-Farber Cancer Institute, Inc. Small molecule inhibitors of apex, alone and in combination with other cancer drugs to inhibit growth of cancer cells
WO2025097033A1 (en) * 2023-11-01 2025-05-08 City Of Hope Metformin combination therapy for use in cancer treatment

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1641940A4 (en) * 2003-07-01 2009-09-02 Mor Research Applic Ltd DETERMINING PROGNOSIS IN PATIENTS WITH EWING SARCOMA BY GENETIC PROFILES
WO2008089034A2 (en) * 2007-01-11 2008-07-24 Kemia, Inc. Cytokine inhibitors
WO2011050210A1 (en) 2009-10-21 2011-04-28 Agios Pharmaceuticals, Inc. Methods and compositions for cell-proliferation-related disorders
ES2642109T3 (es) * 2009-12-09 2017-11-15 Agios Pharmaceuticals, Inc. Compuestos terapéuticamente activos para su uso en el tratamiento de cáncer caracterizados por tener una mutación de IDH
CN112472699A (zh) * 2013-07-26 2021-03-12 种族肿瘤学公司 改善比生群及衍生物的治疗益处的组合方法

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
CHAO, JOSEPH ET AL., ANTICANCER RESEARCH, vol. 30, no. 2, JPN6020022201, February 2010 (2010-02-01), pages 547 - 552, ISSN: 0004451522 *
CURVELLO, R. ET AL., ANNALS OF ONCOLOGY, vol. 24, no. 1, JPN6020022202, March 2013 (2013-03-01), ISSN: 0004451523 *
GAROFALO, CECILIA ET AL., PLOS ONE, vol. Vol. 8, Issue 12, JPN6020022204, December 2013 (2013-12-01), pages 83832, ISSN: 0004292250 *

Also Published As

Publication number Publication date
CA2995642A1 (en) 2017-03-02
CN106714795A (zh) 2017-05-24
US20180243299A1 (en) 2018-08-30
EP3340978A1 (en) 2018-07-04
US10765675B2 (en) 2020-09-08
TW201717926A (zh) 2017-06-01
WO2017035057A1 (en) 2017-03-02
EP3340978A4 (en) 2019-04-10

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