JP2018201968A - Micro-protrusion unit - Google Patents

Abstract

To provide a micro-protrusion unit including a base component whose shape is hardly restricted and improving a sense of use by improving puncture properties.SOLUTION: A micro-protrusion unit 10 according to the present invention includes: a micro-protrusion device 1 including inside-hollow protrusion parts 3 on a base 2; and a base component 4 including a liquid holding space 4k communicated via the base 2 to the insides of the protrusion parts 3, the unit joining the micro-protrusion device 1 to a tip of the base component 4. The micro-protrusion unit 10 is so configured that, when liquid is injected to the inside of the liquid holding space 4k of the base component 4 and an internal pressure is applied, an area including the protrusion parts 3 in the base 2 of the micro-protrusion device 1 is bent into an outward protrusion shape.SELECTED DRAWING: Figure 6

Description

  The present invention relates to a fine protrusion unit.

  In recent years, the supply of agents using microprotrusions with microneedles has attracted attention because of the reason that the same performance as that of the agents supplied by a syringe can be obtained, but the skin is not damaged and there is little pain.

  For example, Patent Document 1 describes a microneedle array having a microneedle group on a pedestal. Patent Document 2 describes a fine nozzle provided with a protrusion protruding outward at the bottom of a resin cup. Patent Document 3 describes a microneedle structure having microneedles on the bottom plane of a fluid chamber.

JP 2014-176568 A JP 2013-172833 A Japanese translation of PCT publication No. 2003-501161

  However, in the microneedle array described in Patent Document 1, a group of needles composed of microneedles is formed directly on the pedestal, and the shape of the pedestal that forms the microneedles is limited. Similarly, in the fine needle described in Patent Document 2, the fine nozzle is formed directly on the bottom of the resin cup, and the shape of the bottom of the resin cup that forms the fine nozzle is limited. Similarly, in the microneedle structure described in Patent Document 3, the microneedle is formed directly on the bottom plane of the fluid chamber, and the shape of the bottom of the fluid chamber is limited. Furthermore, Patent Documents 1 to 3 describe nothing about the viewpoint of improving the puncture property by curving the pedestal part and the like outwardly when liquid is injected and internal pressure is applied. Absent.

  Accordingly, an object of the present invention is to provide a fine projection unit that can improve puncture performance.

  The present invention includes a fine protrusion having a hollow protrusion on the base, and a base part having a liquid holding space communicating with the inside of the protrusion through the base. A microprojection unit in which microprojections are joined, and when liquid is injected into the liquid holding space of the base component and internal pressure is applied, a region having the projections on the base of the microprojections is outward A microprojection unit that curves convexly toward the surface is provided.

  According to the present invention, the shapes of the fine projection tool and the base part are not easily restricted, the puncture property is improved, and the usability is improved.

FIG. 1 is a schematic perspective view of a fine protrusion unit of a preferred embodiment of the fine protrusion unit of the present invention. FIG. 2 is a plan view of the microprojection unit shown in FIG. 1 as viewed from the microprojection tool side. FIG. 3 is a cross-sectional view taken along the line III-III shown in FIG. 4A is a perspective view of one protrusion provided in the fine protrusion unit shown in FIG. 1, and FIG. 4B is a cross-sectional view taken along line IV-IV shown in FIG. 4A. FIG. 5A is an explanatory diagram showing a method for measuring the tip diameter of the projection, and FIG. 5B is a diagram showing a method for measuring the tip diameter of the projection when the projection has a tip opening. FIG. 6 is a schematic cross-sectional view showing a state when the fine protrusion unit shown in FIG. 1 is used. FIG. 7 is a diagram showing an overall configuration of a preferable manufacturing apparatus for manufacturing the fine protrusion unit shown in FIG. FIGS. 8A to 8E are diagrams illustrating a process of manufacturing a fine projection tool using the manufacturing apparatus shown in FIG. FIG. 9 is an explanatory diagram showing a method for measuring the tip angle of the convex portion. FIGS. 10A to 10G are views for explaining a joining process for forming a joint using the manufacturing apparatus shown in FIG. FIGS. 11A to 11F are diagrams for explaining a cutting process in which the fine projection unit is formed by cutting using the manufacturing apparatus shown in FIG. FIGS. 12A to 12D are plan views of the microprojection unit according to another embodiment as viewed from the microprojection tool side.

Hereinafter, the present invention will be described based on a preferred embodiment thereof with reference to the drawings.
A microprojection unit 10 (hereinafter, also simply referred to as “microprojection unit 10”) of a preferred embodiment of the microprojection unit of the present invention includes a microprojection tool 1 including a projecting portion 3 having a hollow inside on a base 2 and the microprojection tool 1. A base part 4 having a liquid holding space 4k (see FIG. 3) communicating with the inside of the protrusion 3 via the base 2 is provided, and the fine protrusion 1 is joined to the tip of the base part 4. FIG. 1 is a perspective view of the fine protrusion unit 10. FIG. 2 shows a plan view of the fine protrusion unit 10. FIG. 3 shows a cross-sectional view of the fine protrusion unit 10.

  Regarding the protrusions 3 of the fine protrusion 1, the number of protrusions 3, the arrangement of the protrusions 3, and the shape of the protrusions 3 are not particularly limited. However, in the fine protrusion unit 10, as shown in FIGS. 1 and 2. On the upper surface of the sheet-like base 2, 25 frustoconical protrusions 3 are arranged. The arranged 25 protrusions 3 are arranged in 5 rows in a second direction (corresponding to the Y direction in the drawing) which is a direction (corresponding to the longitudinal direction of the base sheet 2A) to convey a base sheet 2A described later, They are arranged in five rows in a direction orthogonal to the second direction, which is the conveying direction, and in a first direction (corresponding to the X direction in the figure), which is the width direction of the substrate sheet 2A to be conveyed. In addition, the thickness direction of the fine protrusion unit 10 is described as the Z direction. FIG. 4A is a perspective view of the fine protrusion 1 focusing on one protrusion 3 of the protrusions 3 of the fine protrusion 1, and FIG. 4B is a perspective view of FIG. It is the IV-IV sectional view taken on the line shown to a).

  The microprojection tool 1 shown in FIG. 4 (a) has one sheet-like base 2 and one piece standing on the upper surface of the base 2 (the surface of the base 2 opposite to the surface facing the base part 4). And a conical protrusion 3. The microprojection tool 1 does not have to have an aperture on the tip side, but the microprojection unit 10 has an aperture 3h as shown in FIG. 3, a space 3k penetrating from the base 2 to the opening 3h is formed. In the fine protrusion unit 10, the space 3 k inside the protrusion 3 is formed in a conical shape corresponding to the outer shape of the protrusion 3. In addition, although the projection part 3 is a cone shape in the fine projection unit 10, in addition to a cone shape, a truncated cone shape, a columnar shape, a prism shape, a pyramid shape, a truncated pyramid shape, or the like may be used.

  When the protrusion 3 is used as a microneedle, the protrusion height H1 (see FIG. 4 (b)) is preferable because the tip is inserted into the stratum corneum at the shallowest depth and deep into the dermis. Is 0.01 mm or more, more preferably 0.02 mm or more, and preferably 10 mm or less, more preferably 5 mm or less, still more preferably 3 mm or less, and specifically preferably 0 mm or less. It is 0.01 mm or more and 10 mm or less, More preferably, it is 0.01 mm or more and 5 mm or less, More preferably, it is 0.02 mm or more and 3 mm or less. The protrusion 3 has an average thickness T1 of preferably 0.005 mm or more, more preferably 0.01 mm or more, and preferably 1.0 mm or less, more preferably 0.5 mm or less. Specifically, it is preferably 0.005 mm or more and 1.0 mm or less, and more preferably 0.01 mm or more and 0.5 mm or less.

  The tip diameter of the protrusion 3 is preferably 0.001 mm or more, more preferably 0.005 mm or more, and preferably 0.5 mm or less, more preferably 0.3 mm or less. Specifically, it is preferably 0.001 mm to 0.5 mm, and more preferably 0.005 mm to 0.3 mm. The tip diameter of the protrusion 3 of the fine protrusion 1 is measured as follows.

[Measurement of protrusion 3 tip diameter]
When the tip of the protrusion 3 is not open, the tip of the protrusion 3 of the fine protrusion 1 is enlarged by a predetermined magnification using a scanning electron microscope (SEM) or a microscope, for example, FIG. Observe like the SEM image shown in 5 (a).
Next, as shown in FIG. 5A, an imaginary straight line ILa is extended along a straight line portion on one side 1a of both sides 1a and 1b, and an imaginary straight line ILb along a straight line portion on the other side 1b. Extend. Then, on the distal end side, a location where the one side 1a is separated from the virtual straight line ILa is obtained as the first distal point 1a1, and a location where the other side 1b is separated from the virtual straight line ILb is obtained as the second distal point 1b1. The length L of the straight line connecting the first tip point 1a1 and the second tip point 1b1 thus determined is measured using a scanning electron microscope (SEM) or a microscope, and the measured length of the straight line is measured. Is the tip diameter of the fine projection tool 1. When the projection 3 has an opening 3h as in the fine projection unit 10, as shown in FIG. 5B, the projection 3 has a tip on the opening side. Assuming that there is a virtual straight line ILa, ILb is drawn, the intersection point is set as the apex of the protrusion 3, and the tip diameter is measured by the method shown in FIG.

From the viewpoint of easy supply of the agent by the fine protrusion unit 10, the opening portion 3h is preferably 0.7 μm ² or more, more preferably 20 μm ² or more, and preferably 200000Myuemu ² or less, still more preferably 70000Myuemu ² or less, specifically, preferably at 0.7 [mu] m ² or more 200000Myuemu ² or less, still more preferably 20 [mu] m ² or more 70000Myuemu ² or less.

  As shown in FIGS. 1 and 2, the 25 protrusions 3 arranged on the upper surface of the sheet-like base 2 have a uniform center distance in the second direction and a uniform center distance in the first direction. It is preferable that the distance between the centers in the second direction is the same as the distance between the centers in the first direction. Suitably, the distance between the centers of the protrusions 3 in the second direction is preferably 0.01 mm or more, more preferably 0.05 mm or more, and preferably 10 mm or less, more preferably 5 mm or less. Specifically, it is preferably 0.01 mm or more and 10 mm or less, and more preferably 0.05 mm or more and 5 mm or less. Further, the distance between the centers of the protrusions 3 in the first direction is preferably 0.01 mm or more, more preferably 0.05 mm or more, and preferably 10 mm or less, more preferably 5 mm or less. Specifically, it is preferably 0.01 mm or more and 10 mm or less, and more preferably 0.05 mm or more and 5 mm or less.

  The base 2 is formed into a sheet having a uniform thickness. The base 2 has a thickness T2 (see FIG. 4 (b)), from the viewpoint of easily bending the base 2 convex outwardly when liquid is injected into the liquid holding space 4k and an internal pressure is applied. When the base 2 and the base part 4 are formed of the same kind of material, it is preferably thinner than the thickness T3 (see FIG. 3) at the bottom 41 of the base part 4 described later. The ratio of the thickness T2 of the base 2 to the thickness T3 (T2 / T3) is preferably 0.001 or more, more preferably 0.01 or more, and preferably 1 or less, more preferably 0.5 or less. Moreover, it is preferably 0.001 or more and 1 or less, and more preferably 0.01 or more and 0.5 or less. Preferably, the thickness T2 of the base 2 is preferably 0.01 mm or more, more preferably 0.02 mm or more, and preferably 1.0 mm or less, more preferably 0.7 mm or less. Is preferably 0.01 mm or more and 1.0 mm or less, more preferably 0.02 mm or more and 0.7 mm or less.

  As shown in FIG. 2, the fine protrusion unit 10 has, on the upper surface of the base 2, a region having 25 protrusions 3, that is, a protrusion region 3R that is an area where 25 protrusions 3 are formed. Yes. Here, the protrusion region 3R is surrounded by the protrusions 3 located on the outermost side in the surface direction having the first direction and the second direction when the fine protrusion unit 10 is viewed from the fine protrusion 1 side. It means the area that is. The protruding region 3R is formed inward from the joint 5 with the base component 4 described later.

  As shown in FIG. 3, the base part 4 has a liquid holding space 4 k that communicates with a space 3 k inside the protrusion 3 via a base 2. The base component 4 includes a bottom 41 that forms a lower surface opposite to the upper surface that forms the joint 5 with the microprojection tool 1 and a liquid supply path that passes through the bottom 41 and supplies liquid into the liquid holding space 4k. 42 and a peripheral wall portion 43 that is arranged over the entire outer periphery of the bottom portion 41 and stands on the upper surface of the bottom portion 41 (the surface on the fine projection tool 1 side). A space surrounded by the base 2, the bottom 41, and the peripheral wall 43 of the fine protrusion 1 is a liquid holding space 4 k. Thus, the peripheral wall part 43 is distribute | arranged to the outer periphery of the liquid holding space 4k. The fine protrusion unit 10 is formed so as to be connectable to a syringe or the like that supplies liquid at the supply port of the liquid supply path 42 of the base component 4.

  Regarding the base component 4, the outline 4L shape of the base component 4 when the microprojection unit 10 is viewed in plan from the microprojection tool 1 side, that is, the outer peripheral shape of the bottom 41 is not particularly limited. As shown in FIG. 2, it has a circular shape. The overall outer shape of the base component 4 is formed in a cylindrical shape having a circular bottom 41 in the fine protrusion unit 10 shown in FIG. The outline 4L of the base component 4 is circular in the microprojection unit 10, but in addition to the circular shape, there are an oval shape, a rhombus shape, a triangular shape, a quadrangular shape, a pentagonal shape, etc. Also good. The overall shape of the base part 4 may be a conical shape, a rectangular tube shape, a pyramid shape, or the like other than the cylindrical shape.

The base component 4 has a thickness T3 at the bottom 41 of the base component 4 from the viewpoint of easily bending the base 2 outwardly when liquid is injected into the liquid holding space 4k and internal pressure is applied (see FIG. 3) is preferably thicker than the thickness T2 of the base 2, preferably 1.0 mm or more, more preferably 1.5 mm or more, and preferably 10 mm or less, more preferably 5 mm or less. Specifically, it is preferably 1.0 mm or more and 10 mm or less, and more preferably 1.5 mm or more and 5 mm or less.
Further, from the same viewpoint, the base part 4 preferably has a thickness T4 (see FIG. 3) at the peripheral wall 43 of the base part 4 larger than the thickness T2 of the base 2, preferably 1.0 mm or more, and more preferably. Is 1.5 mm or more, preferably 10 mm or less, more preferably 5 mm or less, specifically preferably 1.0 mm or more and 10 mm or less, more preferably 1.5 mm or more and 5 mm or less. It is.

As shown in FIG. 3, the fine protrusion unit 10 has a cross-sectional view of the fine protrusion unit 10 along the thickness direction, and the joint 5 in which the base component 4 and the fine protrusion 1 are joined to each other. A thickness T2 of the base 2 is formed to be smaller than a length L1 of the base component 4 in the thickness direction. 3 is a cross-sectional view taken along the line III-III shown in FIG. 2, and when the base component 4 is circular when the microprojection unit 10 is viewed from the microprojection tool 1 side, the line III-III is the center of the base component 4 in the circle. It is sectional drawing of the position which passes.
The length L1 of the base component 4 in the thickness direction, which is located at the joint 5, from the viewpoint of easily bending the base 2 outwardly when liquid is injected into the liquid holding space 4k and internal pressure is applied. The ratio (T2 / L1) of the thickness 2 of the base 2 of the microprojection tool 1 to T is preferably 0.005 or more, more preferably 0.01 or more, and preferably 0.5 or less, more preferably Is 0.3 or less, preferably 0.005 or more and 0.5 or less, and more preferably 0.01 or more and 0.3 or less. Preferably, the length L1 of the base component 4 in the thickness direction is preferably 2 mm or more, more preferably 3 mm or more, and preferably 20 mm or less, more preferably 15 mm or less. Specifically, Preferably they are 2 mm or more and 20 mm or less, More preferably, they are 3 mm or more and 15 mm or less.

  As shown in FIGS. 2 and 3, the fine protrusion unit 10 has a contour of the fine protrusion 1, i.e., a fine protrusion, on the inner side of the outline 4 </ b> L of the base component 4 in plan view from the fine protrusion 1 side. An outline 2L of one base 2 is arranged. From the viewpoint of appearance and usability improvement, the contour 2L of the base 2 of the fine projection tool 1 is preferably 0.05 mm or more, more preferably 0.1 mm or more, and more preferably inward from the contour 4L of the base part 4. It is preferably 5 mm or less, more preferably 3 mm or less, specifically preferably 0.05 mm or more and 5 mm or less, more preferably 0.1 mm or more and 3 mm or less, and with a gap W1.

  As shown in FIG. 2, the microprojection unit 10 has a base component 4 at a position within the contour of the microprojection tool, that is, the contour 2 </ b> L of the base 2 of the microprojection tool 1 in plan view from the microprojection tool 1 side. And the junction part 5 which joined the fine projection tool 1 is distribute | arranged. The joint portion 5 is formed in a band shape on the distal end wall portion 43s of the peripheral wall portion 43 disposed over the outer periphery of the liquid holding space 4k of the base part 4, and has an annular shape over the entire outer periphery of the liquid holding space 4k. It is arranged in. Here, “the position within the contour 2L” means that the contour 2L of the base 2 of the fine projection 1 is coincident with the outer peripheral edge of the band-shaped joint 5, or the fine projection 1 It means a state in which the outer peripheral edge of the band-like joint portion 5 is arranged on the inner side than the outline 2L of the base 2.

  In the fine protrusion unit 10, as shown in FIG. 2, the width W2 of the band-like joint portion 5 is preferably set to 0. 0 from the viewpoint of adhesion strength, appearance, and usability when viewed from the fine protrusion 1 side. It is 5 mm or more, more preferably 1 mm or more, and preferably 5 mm or less, more preferably 3 mm or less, specifically preferably 0.5 mm or more and 5 mm or less, more preferably 1 mm or more and 3 mm or less.

  As shown in FIG. 2, the fine protrusion unit 10 is viewed from the fine protrusion 1 side in a plan view, from the viewpoint of cut stability, appearance, and usability improvement, the outer side of the outline 2 </ b> L of the base 2 and the joint 5. Is preferably 0.05 mm or more, more preferably 0.1 mm or more, and preferably 5 mm or less, more preferably 3 mm or less, specifically preferably 0.05 mm or more and 5 mm or less, More preferably, it is 0.1 mm or more and 3 mm or less, and it arrange | positions at intervals W3.

  As shown in FIGS. 2 and 3, in the fine protrusion unit 10, the base component 4 has a bottom 41 that surrounds the liquid holding space 4 k and a peripheral wall 43 that is arranged over the entire outer periphery of the bottom 41. The upper surface of the peripheral wall 43 facing the fine projection 1 is joined to the fine projection 1, and a non-joined region not joined to the fine projection 1 is provided on the liquid holding space 4 k side of the upper surface. Yes. That is, the presence of a non-joining region, which is a region where liquid can enter, between the microprojection tool 1 and the tip wall portion 43s makes it easier for the base portion 2 to bend outwardly when an internal pressure is applied. From the viewpoint of the protrusion 3 being curved outwardly and enhancing the puncture property to the skin, the distance between the inner peripheral edge of the joint area 5 on the inner protrusion area 3R side and the inner wall of the tip wall 43s of the peripheral wall 43 W4 is preferably 0.05 mm or more, more preferably 0.1 mm or more, and preferably 5 mm or less, more preferably 3 mm or less, specifically preferably 0.05 mm or more and 5 mm or less, more preferably 0. It is preferable that they are arranged with a distance W4 of 1 mm or more and 3 mm or less.

  As shown in FIGS. 1 and 3, the fine protrusion unit 10 includes a fine protrusion 1 having a protrusion 3 on a base 2 and a base part 4, and a fine protrusion at the tip of the base part 4. 1 is joined, the shape of the fine projection tool 1 and the base part 4 is not easily limited, and the degree of freedom in selecting the base part 4 is high. Further, in the fine protrusion unit 10, the liquid is supplied from a syringe or the like into the liquid holding space 4k of the base component 4 through the liquid supply path 42 during use, and the liquid is supplied into the liquid holding space 4k as shown in FIG. When the inner pressure is applied after the injection, the region having the protrusion 3 in the base 2 of the fine protrusion 1 is curved to protrude outward. Thus, when the area | region which has the projection part 3 in the base 2 of the fine projection tool 1 curves outwardly, the puncture property of the 25 projection parts 3 distribute | arranged to the upper surface of the base 2 will improve, and it uses it. A feeling improves. In particular, in the 25 protrusions 3 arranged on the upper surface of the base 2, the puncture directions of the remaining 24 protrusions 3 extend radially from the central protrusion 3. Improves the usability.

  In particular, as shown in FIG. 3, the fine protrusion unit 10 is formed such that the base 2 of the fine protrusion 1 has a thickness T <b> 2 smaller than a length L <b> 1 in the thickness direction of the base component 4 at the joint 5. ing. Since it is formed in this way and has a base that can be bent outward, the base 2 of the fine projection tool 1 tends to bend following the unevenness of the skin of the user, and the puncture property of the projection 3 is improved. The feeling of use improves.

The fine protrusion unit 10 described above can be manufactured using, for example, a manufacturing apparatus 100 described later. FIG. 7 shows the overall configuration of a manufacturing apparatus 100 used for carrying out the manufacturing method of the fine protrusion unit 10. Hereinafter, a method for manufacturing the fine protrusion unit 10 using the manufacturing apparatus 100 will be described with reference to FIGS. As described above, the protrusion 3 of the fine protrusion unit 10 is very small, but for convenience of explanation, the protrusion 3 is drawn very large in each drawing.
In the following description, the direction in which the base sheet 2A is transported (the longitudinal direction of the base sheet 2A) is the Y direction, the direction orthogonal to the transport direction and the width direction of the transported base sheet 2A are transported in the X direction. The thickness direction of the base material sheet 2 </ b> A will be described as the Z direction.

  The manufacturing method of the fine protrusion unit 10 makes the convex part 11 contact from the one surface 2D side of the base sheet 2A formed including the thermoplastic resin, and protrudes from the other surface 2U side of the base sheet 2A. After forming the protrusion 3, a fine protrusion forming process for forming the fine protrusion 1 by removing the convex portion 11 from the inside of the protrusion 3, and one surface 2D of the base sheet 2A on which the fine protrusion 1 is formed The base material sheet 2A to which the base component 4 is bonded and the base component 4 in a plan view from the side of the fine protrusions 1 when viewed in plan from the side of the outline 4L of the base component 4 A cutting step of manufacturing the fine protrusion unit 10 by cutting the material sheet 2A.

As shown in FIG. 7, in the manufacturing apparatus 100, the fine protrusion forming part 200 and the fine protrusion 1 are formed to form the fine protrusion 1 from the upstream side to the downstream side in the transport direction (corresponding to the Y direction). There are provided a member joining portion 300 for joining the base material sheet 2A and the base component 4 and a member cutting portion 400 for producing the fine protrusion unit 10 by cutting the base material sheet 2A. In the manufacturing apparatus 100, as shown in FIG. 8, the fine projection forming unit 200 includes a projection forming unit 210 that forms the projection 3 on the base sheet 2A, a cooling unit 220, and a release unit 230 that extracts the convex mold unit 11. It has.
In the present specification, the convex part 11 is a member provided with a convex mold 110 that is a part that pierces the base sheet 2A. In this embodiment, the convex part 11 is a disk-shaped base part. The structure is arranged above. However, the present invention is not limited thereto, and may be a convex portion composed only of the convex mold 110, or may be the convex portion 11 in which a plurality of convex molds 110 are arranged on a table-like support.

  The protruding portion forming portion 210 will be described with reference to FIGS. As shown in FIGS. 7 and 8, the protruding portion forming portion 210 includes a convex portion 11 having a heating means (not shown). In the manufacturing apparatus 100, the convex part 11 may be provided with a heating means. In addition, in the manufacturing apparatus 100, other heating means than the heating means of the convex portion 11 may not be provided. In the present specification, “no other heating means other than the heating means of the convex portion 11” indicates not only the case where other heating means are excluded, but also the softening temperature of the base sheet 2A. Less than or less than the glass transition temperature. However, it is preferable not to include any other heating means. In the manufacturing apparatus 100, the heating means of the convex part 11 is an ultrasonic vibration device.

  In the method of manufacturing the fine protrusion unit 10 using the manufacturing apparatus 100, first, as shown in FIG. 7, the belt-shaped base sheet 2A is fed out from the raw material roll of the base sheet 2A formed to contain the thermoplastic resin, and conveyed. Transport in the direction. And when base material sheet 2A is sent to the predetermined position, conveyance of base material sheet 2A is stopped. Thus, in the manufacturing method of the fine projection unit 10, the belt-shaped base sheet 2A is intermittently conveyed.

  The base sheet 2A is a sheet that becomes the base 2 of the fine protrusion 1 to be manufactured, and is formed to include a thermoplastic resin. Examples of the thermoplastic resin include poly fatty acid ester, polycarbonate, polypropylene, polyethylene, polyester, polyamide, polyamideimide, polyetheretherketone, polyetherimide, polystyrene, polyethylene terephthalate, polyvinyl chloride, nylon resin, acrylic resin, etc. From the viewpoint of biodegradability, poly fatty acid esters are preferably used. Specific examples of the polyfatty acid ester include polylactic acid, polyglycolic acid, and combinations thereof. The base sheet 2A may be formed of a mixture containing hyaluronic acid, collagen, starch, cellulose and the like in addition to the thermoplastic resin. The thickness of the base sheet 2A is equal to the thickness T2 of the base 2 of the fine projection 1 to be manufactured.

  Next, in the fine protrusion forming process of the manufacturing method of the fine protrusion unit 10, as shown in FIG. 8A and FIG. 8B, from the one surface 2D side of the strip-shaped base sheet 2A conveyed in the conveyance direction. The convex part 11 is stabbed into the base sheet 2A while protruding from the other surface 2U side of the base sheet 2A while the convex part 11 is brought into contact and the contact part TP in the base sheet 2A is softened by heat. The projection 3 to be formed is formed (projection formation step). In the protrusion part formation part 210, the opening plate 12U as a bending suppression means is arrange | positioned at the other surface 2U side (upper surface side) of the base material sheet 2A, and as a bending suppression means at the one surface 2D side (lower surface side) of the base material sheet 2A. The second opening plate 13D is arranged.

The convex portion 11 has a shape having a conical portion with a sharp tip corresponding to the outer shape of the conical protrusion 3 of the fine protrusion 1 to be manufactured. That is, in the manufacturing apparatus 100, as shown in FIG. 7, the convex mold part 11 includes a convex mold 110 corresponding to the number and arrangement of the projections 3 of the fine projection tool 1 to be manufactured and the substantially outer shape of each projection part 3. And 25 conical convex molds 110 corresponding to the 25 frustoconical protrusions 3. In this way, a plurality of protrusions 3 arranged on the upper surface of the sheet-like base 2 are formed using the convex portion 11 having a plurality of convex molds 110. In the manufacturing apparatus 100, the convex part 11 is arranged with the tip of each convex part 110 facing upward, and is movable at least up and down in the thickness direction. Preferably, in the manufacturing apparatus 100, the convex portion 11 is movable up and down in the thickness direction by an electric actuator (not shown). In addition, it is preferable that the action | operation of the heating means of the convex-shaped part 11 is performed from just before the convex-shaped part 11 contact | abuts to the base material sheet 2A until just before the cooling process of the following process.
The control of the heating conditions of the heating means provided in the convex part 11 such as the operation of the convex part 11 and the operation of the heating means of the convex part 11 is controlled by a control means (not shown) provided in the manufacturing apparatus 100. Yes.

  As described above, the heating means of the convex portion 11 is an ultrasonic vibration device in the manufacturing apparatus 100. Regarding the ultrasonic vibration of the convex portion 11 by the ultrasonic vibration device, the frequency is preferably 10 kHz or more and 50 kHz or less, more preferably 15 kHz or more and 40 kHz or less from the viewpoint of forming the protrusion 3. Further, regarding the ultrasonic vibration of the convex portion 11 by the ultrasonic vibration device, the amplitude is preferably 1 μm or more and 60 μm or less, and more preferably 5 μm or more and 50 μm or less, from the viewpoint of forming the protrusion 3.

The shape on the front end side of the convex portion 11 only needs to be a shape corresponding to the outer shape of the protrusion 3 of the fine protrusion 1 to be manufactured. The convex mold 110 of the convex mold part 11 is formed such that its height H2 (see FIG. 7) is the same as or slightly higher than the height H1 of the projecting part 3 of the microprojection tool 1 to be manufactured. It is 0.01 mm or more and 30 mm or less, More preferably, it is 0.02 mm or more and 20 mm or less. The convex mold 110 of the convex mold section 11 has a tip diameter D1 (see FIG. 9) of preferably 0.001 mm to 1 mm, and more preferably 0.005 mm to 0.5 mm. The tip diameter D1 of the convex mold 110 of the convex mold part 11 is measured as follows.
The convex mold 110 of the convex mold part 11 has a root diameter D2 of preferably 0.1 mm or more and 5 mm or less, and more preferably 0.2 mm or more and 3 mm or less. From the viewpoint of obtaining sufficient strength, the tip angle α of the convex part 110 of the convex part 11 is preferably 1 degree or more and 60 degrees or less, and more preferably 5 degrees or more and 45 degrees or less. The tip angle α of the convex portion 11 is measured as follows.

[Measurement of the tip diameter of the convex part 110 of the convex part 11]
The tip part of the convex part 110 of the convex part 11 is observed in a state of being enlarged to a predetermined magnification using a scanning electron microscope (SEM) or a microscope. Next, as shown in FIG. 9, a virtual straight line ILc is extended along a straight line portion on one side 11a of both side edges 11a and 11b, and a virtual straight line ILd is extended along a straight line portion on the other side 11b. Then, on the distal end side, a location where the one side 11a is separated from the virtual straight line ILc is obtained as the first distal point 11a1, and a location where the other side 11b is separated from the virtual straight line ILd is obtained as the second distal point 11b1. The length D1 of the straight line connecting the first tip point 11a1 and the second tip point 11b1 thus determined is measured using a scanning electron microscope (SEM) or a microscope, and the measured length of the straight line is measured. Is the tip diameter of the convex mold 110.

[Measurement of Tip Angle α of Convex Mold 110 of Convex Mold Part 11]
The tip part of the convex part 110 of the convex part 11 is observed as a SEM image shown in FIG. 9, for example, in a state where it is enlarged by a predetermined magnification using a scanning electron microscope (SEM) or a microscope. Next, as shown in FIG. 9, a virtual straight line ILc is extended along a straight line portion on one side 11a of both side edges 11a and 11b, and a virtual straight line ILd is extended along a straight line portion on the other side 11b. Then, the angle formed between the virtual straight line ILc and the virtual straight line ILd is measured using a scanning electron microscope (SEM) or a microscope, and the measured angle is determined as the tip angle α of the convex mold 110 of the convex portion 11. And

  The convex part 11 is formed of a high-strength material that is difficult to break. Examples of the material of the convex portion 11 include steel, stainless steel, aluminum, aluminum alloy, nickel, nickel alloy, cobalt, cobalt alloy, copper, copper alloy, beryllium copper, and beryllium copper alloy, or ceramic. .

  As described above, the opening plate 12U used in the protruding portion forming step is arranged on the other surface 2U side of the base sheet 2A as shown in FIGS. 7 and 8, and the convex portion 11 is formed from the one surface 2D side. The base sheet 2 </ b> A serves to make it difficult to bend when stabbed. Therefore, the opening plate 12U is a region other than the region where the convex portion 11 is inserted in the base sheet 2A, in other words, a region other than the protrusion region 3R that is the region where the protrusion 3 is formed in the base sheet 2A. It is arranged to support. In the manufacturing apparatus 100, the opening plate 12U arranged in this way is a plate-like opening plate having an opening 12a that is opened so as to surround the protruding region 3R. In the opening plate 12U, the base sheet 2A is supported in a region other than the opening 12a.

  In the manufacturing apparatus 100, the opening plate 12U is formed with one opening 12a as shown in FIG. 7, and the opening area of one opening 12a is a plurality of the protrusions 110 in the protrusion 11. It is formed larger than the total cross-sectional area of the convex mold 110 so that it can be inserted. In addition, the opening part 12a of the opening plate 12U may be formed with two or more corresponding to each convex mold | type 110 so that the several convex mold | type 110 may each be penetrated.

The opening plate 12U is movable in a direction in which it comes into contact with the base sheet 2A and in a direction in which it is separated. In the manufacturing apparatus 100, the opening plate 12U can be moved up and down in the thickness direction by an electric actuator.
The control of the operation of the aperture plate 12U is controlled by a control means provided in the manufacturing apparatus 100.

  The material constituting the opening plate 12U may be the same material as that of the convex portion 11, or may be formed of a synthetic resin or the like.

  The manufacturing apparatus 100 includes an ultrasonic vibration device as a heating unit for the convex portion 11. In the manufacturing method of the fine protrusion unit 10, the protrusion formation process is performed with the base plate 2A sandwiched between the opening plate 12U and the second opening plate 13D. In the projection forming step using the manufacturing apparatus 100, the convex portion 11 is passed from the one surface 2D side (lower surface side) of the base sheet 2A to the opening portion 13a of the second opening plate 13D described later, and FIG. As shown in FIG. 5, the ultrasonic vibration device causes each convex portion 11 to express ultrasonic vibration in advance, and then the convex portion 11 is brought into contact with one surface 2D of the base sheet 2A. Thereby, the contact part TP is softened. Then, as shown in FIG. 8 (b), the convex portion 11 is moved from the one surface 2D side (lower surface side) to the other surface 2U side (upper surface side) while softening the contact portion TP. The convex portion 11 is pierced into the base sheet 2 </ b> A while being suppressed by the opening plate 12 </ b> U disposed on the other surface 2 </ b> U (upper surface side) side of the base sheet 2 </ b> A. And the projection part 3 which protrudes from the other surface 2U side (upper surface side) of the base material sheet 2A is formed.

  The heating temperature of the base sheet 2A by heating the convex part 11 is preferably not less than the glass transition temperature of the base sheet 2A to be used and less than the melting temperature from the viewpoint of forming the protrusions 3, and particularly not less than the softening temperature. It is preferably below the melting temperature. More specifically, the heating temperature is preferably 30 ° C. or higher and 300 ° C. or lower, more preferably 40 ° C. or higher and 250 ° C. or lower. In addition, when heating base material sheet 2A using an ultrasonic vibration apparatus, it applies as a temperature range of the part of base material sheet 2A which contacted the convex mold | type 110. FIG. On the other hand, when the base sheet 2A is heated using a heater device instead of the ultrasonic vibration device, the heating temperature of the convex portion 11 may be adjusted within the above-described range. The glass transition temperature (Tg) is measured by the following method, and the softening temperature is measured according to JIS K-7196 “Softening temperature test method by thermomechanical analysis of thermoplastic film and sheet”. .

[Measurement method of glass transition temperature (Tg)]
The amount of heat is measured using a DSC measuring instrument to determine the glass transition temperature. Specifically, the measuring instrument uses a differential scanning calorimeter (Diamond DSC) manufactured by Perkin Elmer. 10 mg of a test piece is collected from the base sheet. The measurement condition is maintained at 20 ° C. for 5 minutes, and then the temperature is raised from 20 ° C. to 320 ° C. at 5 ° C./min to obtain a DSC curve of the horizontal axis temperature and the vertical axis calorie. And glass transition temperature Tg is calculated | required from this DSC curve.

The “glass transition temperature (Tg) of the base sheet” means the glass transition temperature (Tg) of the constituent resin of the base sheet, and when there are a plurality of types of the constituent resins, the plurality of types of glass transitions. When the temperatures (Tg) are different from each other, the heating temperature of the base sheet by the heating means is preferably at least the lowest glass transition temperature (Tg) among the plurality of glass transition temperatures (Tg), More preferably, the glass transition temperature (Tg) is higher than the highest glass transition temperature (Tg).
Further, the "softening temperature of the base sheet" is also the same as the glass transition temperature (Tg), that is, when there are a plurality of types of constituent resins of the base sheet, when the plurality of types of softening temperatures are different from each other, The heating temperature of the base sheet by the heating means is preferably at least the lowest softening temperature among the plurality of softening temperatures, and more preferably at least the highest softening temperature among the plurality of softening temperatures.
Moreover, when the base sheet is configured to include two or more kinds of resins having different melting points, the heating temperature of the base sheet by the heating means is preferably less than the lowest melting point among the plurality of melting points. .

  From the viewpoint of efficiently forming the protrusion 3, the insertion speed for piercing the base sheet 2 </ b> A into the base sheet 2 </ b> A causes the resin to be excessively heat-softened if it is too slow, and if it is too fast, the heat-softening is insufficient. Preferably, it is 0.1 mm / second or more and 1000 mm / second or less, and more preferably 1 mm / second or more and 800 mm / second or less. If the heating time of the convex part 11 is stopped, the softening time, which is the time until the cooling process of the next process is performed with the convex part 11 stuck in the protrusion 3, is excessively heated. However, from the viewpoint of compensating for insufficient heating, it is preferably 0 second or longer and 10 seconds or shorter, and more preferably 0.1 second or longer and 5 seconds or shorter.

  From the viewpoint of efficiently forming the protrusion 3, the insertion height of the convex portion 11 that pierces the base sheet 2 </ b> A is preferably 0.01 mm or more and 10 mm or less, and more preferably 0.02 mm or more and 5 mm or less. is there. Here, “the insertion height” means that the apex of the convex portion 11 and the other surface 2U (upper surface) of the base sheet 2A in the state where the convex portion 11 is most inserted into the base sheet 2A. Means the distance between. Therefore, the piercing height in the protruding portion forming step means that the protruding portion 11 is deeply inserted in the protruding portion forming step and the protruding portion 11 comes out from the other surface 2U of the base sheet 2A. It is the distance from the other surface 2U to the apex of the convex portion 11 measured in the vertical direction.

  In addition, since the fine projection tool 1 has the opening 3h in the vicinity of the tip of the projection 3, the operation of the convex portion 11 and / or the heating provided in the convex portion 11 in the projection formation step. By controlling the heating conditions and the like of the means, the substrate sheet 2A is inserted until it penetrates the convex part 11, and the hole part 3h is formed.

  Next, in the manufacturing apparatus 100, as shown in FIG. 8C, the cooling unit 220 is installed next to the protrusion forming unit 210. The cooling unit 220 includes, for example, a cold air blower (not shown). In the fine protrusion forming process of the manufacturing method of the fine protrusion unit 10, the convex part 11 is stabbed inside the protrusion 3 by using the manufacturing apparatus 100 and using the cold air blower after the protrusion forming process. The protrusion 3 is cooled in the state (cooling step). Specifically, in the manufacturing apparatus 100, the opening plate 12U is disposed on the other surface 2U side (upper surface side) of the base sheet 2A, and the second opening plate 13D described later on the one surface 2D side (lower surface side) of the base sheet 2A. Is arranged. Therefore, in the manufacturing method of the fine protrusion unit 10, the cooling process is performed with the base plate 2A sandwiched between the opening plate 12U and the second opening plate 13D. As shown in FIG. 4, in the manufacturing apparatus 100, the cold air blowing device is provided with an air blowing port 21 for blowing cold air on the other surface 2U side (upper surface side) of the base sheet 2 </ b> A, and blows cold air from the air blowing port 21. Then, cooling is performed while the protruding portion 11 is pierced inside the protruding portion 3. When cooling, the heating of the convex portion 11 by the heating device may be in a continuous state or stopped, but the stopped state is preferable.

  The temperature of the cold air to be blown is preferably −50 ° C. or higher and 26 ° C. or lower, more preferably −40 ° C. or higher and 10 ° C. or lower, from the viewpoint of forming the protrusion 3. The cooling time for cooling by blowing cold air is preferably 0.01 seconds or more and 60 seconds or less, more preferably 0.5 seconds or more and 30 seconds or less, from the viewpoint of compatibility between moldability and processing time.

  In addition, when the heating means of the convex part 11 is ultrasonic vibration like the manufacturing apparatus 100, it is not always necessary to provide a cold air blower, and cooling is performed by turning off the vibration of the ultrasonic vibration device. You can also. In this respect, it is preferable to use ultrasonic vibration as a heating means because it facilitates the manufacture of the fine projection tool 1 at high speed as well as simplification of the apparatus. Further, in the portion of the base sheet 2A that is not in contact with the convex portion 11, heat is more difficult to be transmitted, and cooling is efficiently performed by turning off the ultrasonic vibration, so that deformation other than the molded portion occurs. There is an advantage that it is difficult.

  Next, in the manufacturing apparatus 100, as shown in FIG. 8D, a release unit 230 is installed next to the cooling unit 220. In the fine protrusion forming process of the method for manufacturing the fine protrusion unit 10, the protruding part 11 is removed from the protrusion 3 to form the fine protrusion 1 after the cooling process (release process). In the release step, the fine projection tool 1 is formed using the second opening plate 13D as a deflection suppressing means for suppressing the deflection of the base sheet 2A when the convex portion 11 is pulled out from the inside of the projection portion 3. In the manufacturing apparatus 100, the second opening plate 13D used in the release process is disposed on the one surface 2D side of the base sheet 2A, and is disposed at a position corresponding to a predetermined position to which the base sheet 2A is fed.

  As shown in FIGS. 7 and 8, the second opening plate 13D used in the release process is arranged on the one surface 2D side of the base material sheet 2A, and when the convex portion 11 is pulled out from the one surface 2D side, the base material sheet 2A serves to make it difficult to bend. Accordingly, the second opening plate 13D is a region other than the region where the convex portion 11 in the base sheet 2A is pulled out, in other words, a region other than the projection region 3R which is a region where the projection 3 is formed in the base sheet 2A. It is arranged to support. In the manufacturing apparatus 100, the second opening plate 13D arranged in this way is a plate-like second opening plate having an opening 13a that is opened so as to surround the protruding region 3R. In the second opening plate 13D, the base sheet 2A is supported in a region other than the opening 13a.

  As shown in FIG. 8, the second opening plate 13 </ b> D has one opening 13 a formed in the manufacturing apparatus 100, and the opening area of the one opening 13 a is that of the convex 110 in the convex part 11. It is formed larger than the total cross-sectional area of the convex mold 110 so that a plurality can be inserted. In addition, the opening part 13a of 2nd opening plate 13D may be formed with two or more corresponding to each convex mold | type 110 so that the several convex mold | type 110 may each be penetrated. In the manufacturing apparatus 100, the opening 13a of the second opening plate 13D is arranged concentrically with the opening 12a of the opening plate 12U. Therefore, the opening 12a of the pair of opening plates 12U that sandwich the base sheet 2A and the opening 13a of the second opening plate 13D overlap in the thickness direction.

  In the manufacturing apparatus 100, the opening 12a of the opening plate 12U and the opening 13a of the second opening plate 13D have the same opening shape. The opening portions 12a and 13a are not particularly limited in shape when the opening plates 12U and 13D are viewed from the upper surface side. However, in the manufacturing apparatus 100, both are formed in a circular shape. The opening diameter of 13a is the same.

The second opening plate 13D may be fixed, but in the manufacturing apparatus 100, the second opening plate 13D is movable in a direction in which the second opening plate 13D is in contact with the base sheet 2A and in a direction in which the second opening plate 13D is separated. The second opening plate 13D can be moved up and down in the thickness direction by an electric actuator (not shown).
Control of the operation of the second opening plate 13D is controlled by control means (not shown) provided in the manufacturing apparatus 100.

  The material constituting the second opening plate 13D may be the same material as the material constituting the opening plate 12U or the convex portion 11, or may be formed from a synthetic resin or the like.

  In the manufacturing apparatus 100, the opening plate 12U is disposed on the other surface 2U side (upper surface side) of the base sheet 2A, and the second opening plate 13D is disposed on the one surface 2D side (lower surface side) of the base sheet 2A. Therefore, the release process is performed with the base plate 2A sandwiched between the opening plate 12U and the second opening plate 13D. In the method of manufacturing the fine protrusion unit 10, as shown in FIG. 8E, after performing the release process with the base plate 2A sandwiched between the opening plate 12U and the second opening plate 13D, the second opening The plate 13D is moved downward and the opening plate 12U is moved upward to form the fine projection 1 having the hollow projection 3 in the base sheet 2A (microprojection formation step).

  Next, as shown in FIG. 7, the base sheet 2 </ b> A on which the fine protrusion 1 having the protrusion 3 is formed is moved in the transport direction (Y direction). As shown in FIGS. 7 and 10, in the subsequent process of the fine protrusion forming process, one surface 2D side (lower surface side) of the base sheet 2 </ b> A on which the fine protrusion 1 manufactured in the fine protrusion forming process is formed. ) And the tip of the base component 4 are joined (joining step). Here, the tip of the base component 4 is a portion of the base component 4 that is located closest to the one surface 2D side (lower surface side) of the base sheet 2A. In the fine protrusion unit 10, the liquid holding space 4k of the base component 4 is defined. It is a tip wall portion 43 s that is the tip of the peripheral wall portion 43 arranged over the outer periphery. A joining process is performed using the member junction part 300 of the manufacturing apparatus 100 which joins the base material sheet 2A in which the fine projection tool 1 was formed, and the base component 4. FIG.

  In the case where the joint part 5 is formed by fusion, the base part 4 is formed including the same kind of thermoplastic resin as the base sheet 2A from the viewpoint of ease of formation of the joint part 5. Is preferred. Examples of the thermoplastic resin include poly fatty acid ester, polycarbonate, polypropylene, polyethylene, polyester, polyamide, polyamideimide, polyetheretherketone, polyetherimide, polystyrene, polyethylene terephthalate, polyvinyl chloride, nylon resin, acrylic resin, etc. From the viewpoint of biodegradability, poly fatty acid esters are preferably used. Specific examples of the polyfatty acid ester include polylactic acid, polyglycolic acid, and combinations thereof. In addition, when forming the junction part 5 using an adhesive agent, the base component 4 may be formed with the raw material different from the base material sheet 2A, for example, may be metal.

  In the manufacturing apparatus 100, as shown in FIGS. 7 and 10, the member joining portion 300 includes a base component fixing portion 301 that fixes the base component 4, a base sheet 2A on which the fine protrusions 1 are formed, and the base component 4. The upper opening plate 312U and the lower opening plate 313D sandwiching the base sheet 2A on which the fine protrusion 1 having the protrusion 3 is formed. The base component fixing portion 301 has a concave portion 303 having a shape corresponding to the entire outer shape of the base component 4. In the microprojection unit 10, the recess 303 is formed in a shape in which the bottom 41 is fitted into a circular cylinder.

As shown in FIG. 7, the base component fixing portion 301 has a recess 303 and is disposed on the one surface 2D (lower surface) side of the base sheet 2A, and in the recess 303, on the bottom 41 side of the base component 4 The bottom part 41 side of the base part 4 is held so that the outer end wall part 43s of the peripheral wall part 43 of the base part 4 is exposed. Although the base component fixing portion 301 may be fixed, in the manufacturing apparatus 100, the base component fixing portion 301 is movable in a direction in which the base component fixing portion 301 is in contact with the base sheet 2A and in a direction in which the base component fixing portion 301 is separated. Specifically, the base component fixing portion 301 is movable up and down in the thickness direction by an electric actuator (not shown).
Control of the operation of the base component fixing unit 301 is controlled by a control means (not shown) provided in the manufacturing apparatus 100.

  The base component fixing part 301 may be made of the same material as that of the convex part 11 or may be made of synthetic resin or the like.

  The joining portion 302 is a portion that joins the base sheet 2 </ b> A on which the fine protrusion 1 is formed and the base component 4. As shown in FIGS. 7 and 10, the joint portion 302 surrounds the projection region 3 </ b> R, which is a region where the projection portion 3 is formed in the base sheet 2 </ b> A, and further corresponds to the peripheral wall portion 43 of the base component 4. It has an annular tip 302s. The joint portion 302 having the tip portion 302s is formed in a cylindrical shape having an opening on the tip portion 302s side. The width of the front end portion 302 s of the joint portion 302 is preferably narrower than the width of the front end wall portion 43 s of the peripheral wall portion 43 of the base part 4, and substantially coincides with the width W <b> 2 of the band-shaped joint portion 5.

As shown in FIGS. 7 and 10, the joint portion 302 is disposed on the other surface 2U (upper surface) side of the base sheet 2A. In the manufacturing apparatus 100, the joining portion 302 can move in a direction in which the joining portion 302 abuts on the base sheet 2 </ b> A and a direction in which the joining portion 302 moves away. Specifically, the joint portion 302 can be moved up and down in the thickness direction by an electric actuator (not shown).
Control of the operation of the joint portion 302 is controlled by a control means (not shown) provided in the manufacturing apparatus 100.

  Examples of means for joining in the joining step include means such as heat sealing, ultrasonic waves, laser, or adhesive. In the manufacturing apparatus 100, means for joining the joining portion 302 is joining means by heat sealing. The heat seal, the ultrasonic wave, and the laser are joining means for joining the materials such as the base material sheet 2A and the base part 4 by melting and joining with heat, that is, using fusion. Moreover, as an adhesive agent, the hot-melt-adhesive agent etc. which are conventionally utilized for this kind of goods can be utilized.

  As shown in FIG. 10, the lower opening plate 313 </ b> D is arranged on the one surface 2 </ b> D (lower surface) side of the base sheet 2 </ b> A and is formed of a plate-like plate having one opening 313 a. The opening area of the opening 313a is larger than the plane area of the base component fixing portion 301 so that the base component fixing portion 301 can be inserted when the base component fixing portion 301 is moved upward in the thickness direction from the one surface 2D side. Is formed.

  As shown in FIG. 10, the upper opening plate 312U is disposed on the other surface 2U (upper surface) side of the base sheet 2A, and is formed of a plate-like plate having one opening 312a. The opening area of the opening 312a is formed larger than the plane area of the joint 302 so that the joint 302 can be inserted when the joint 302 is moved downward in the thickness direction from the other surface 2U side.

The lower opening plate 313D and the upper opening plate 312U are movable in a direction in which the lower opening plate 313D and the upper opening plate 312U are in contact with the base sheet 2A. In the manufacturing apparatus 100, the lower opening plate 313D and the upper opening plate 312U are movable up and down in the thickness direction by an electric actuator (not shown).
Control of the operations of the lower opening plate 313D and the upper opening plate 312U is controlled by a control means (not shown) provided in the manufacturing apparatus 100.

  In the manufacturing method of the fine protrusion unit 10, as shown in FIG. 10A, the outer shape of the base part 4 on the bottom 41 side is fitted into the recess 303 of the base part fixing part 301, so that the peripheral wall part of the base part 4 is fitted. The base part 4 is held so that the tip wall 43s of 43 is exposed.

  Next, in the method of manufacturing the fine protrusion unit 10, as shown in FIG. 10B, the lower opening plate 313D is moved upward and the upper opening plate 312U is moved downward, so that the lower opening plate 313D and the upper opening plate 313D are moved upward. With the opening plate 312U, the base sheet 2A on which the fine protrusions 1 are formed is sandwiched at a position outside the protrusion region 3R of the protrusion 3 in the base sheet 2A. In this manner, the base sheet 2A on which the fine protrusions 1 are formed is sandwiched between the lower opening plate 313D and the upper opening plate 312U. And as shown in FIG.10 (c), the base component 4 is put into the opening part 313a of lower side opening plate 313D from the one surface 2D side (lower surface side) of the base material sheet 2A in the state which pinched | interposed the base material sheet 2A. The held base part fixing part 301 is passed, and the tip wall part 43s of the peripheral wall part 43 of the base part 4 is brought into contact with the one surface 2D of the base sheet 2A.

  Further, as shown in FIG. 10 (d), the other surface of the base sheet 2A with the base sheet 2A on which the fine protrusions 1 are formed sandwiched between the lower opening plate 313D and the upper opening plate 312U. From the 2U side (upper surface side), the joint 302 is passed through the opening 312a of the upper opening plate 312U, and the annular tip 302s of the joint 302 is brought into contact with the other surface 2U of the base sheet 2A. In addition, after making the annular | circular shaped front-end | tip part 302s of the junction part 302 contact | abut on the other surface 2U of the base material sheet 2A, the base | substrate with which the fine projection tool 1 was formed with the lower side opening plate 313D and the upper side opening plate 312U. It is good also as a state which pinched material sheet 2A.

  And in the manufacturing method of the fine protrusion unit 10, as shown in FIG.10 (e), the state which pinched | interposed the base material sheet 2A in which the fine protrusion tool 1 was formed by lower side opening plate 313D and upper side opening plate 312U Then, heating is performed at the annular tip 302s of the joint 302, and the portion of the base sheet 2A located on the tip wall 43s of the peripheral wall 43 of the base part 4 and the tip wall 43s of the base part 4 The joining portion 5 of the fine projection unit 10 is formed while melting the substrate, and the one surface 2D side (lower surface side) of the base sheet 2A on which the fine projection tool 1 is formed and the tip of the base component 4 are joined. After the junction 5 of the fine protrusion unit 10 is formed, the heating of the junction 302 is stopped.

The heating temperature when the bonding portion 302 is brought into contact with the base material sheet 2A is preferably 100 ° C. or higher, more preferably 120 ° C. or higher, and preferably 300 ° C. or lower, more preferably 250 ° C. Specifically, it is preferably 100 ° C. or higher and 300 ° C. or lower, and more preferably 120 ° C. or higher and 250 ° C. or lower.
The heating time when the bonding portion 302 is brought into contact with the base material sheet 2A is preferably 0.1 seconds or more, and preferably 5.0 seconds or less, specifically, preferably 0.1. 2 seconds or more and 5.0 seconds or less.
The pressing force (pressing force) when the joining portion 302 is brought into contact with the base sheet 2A is preferably 10N or more, and preferably 100N or less, specifically, preferably 10N or more and 100N or less. It is.

  After performing a joining process, as shown in FIG.10 (f), the junction part 302 is moved to the upper direction of the thickness direction from the other surface 2U side (upper surface side) of the base material sheet 2A. Then, as shown in FIG. 10G, the lower opening plate 313D is moved downward and the upper opening plate 312U is moved upward. In this way, the base sheet 2 </ b> A to which the base component 4 is bonded and the fine protrusions 1 are arranged is formed on the base component fixing portion 301.

  Next, as shown in FIG. 7, the base sheet 2 </ b> A on which the fine protrusion 1 having the protrusion 3 is formed and the base component 4 is bonded is moved in the transport direction (Y direction). In the subsequent process of the joining process, the base material sheet 2A manufactured in the joining process and joined with the base part 4 is viewed in plan view from the fine protrusion 1 side, and the base is formed inside the outline 4L of the base part 4. The base sheet 2A is cut along the outline 4L of the component 4 to manufacture the fine protrusion unit 10 (cut process). Here, the inside of the outline of the base part 4 is, in other words, the inside of the outer periphery of the bottom 41 of the base part 4. In a cutting process, it cuts using the member cut part 400 which cuts the base material sheet 2A and manufactures the fine protrusion unit 10. FIG.

  In the manufacturing apparatus 100, as shown in FIGS. 7 and 11, the member cutting unit 400 includes a base component fixing unit 401 that fixes the base component 4 and a cutting unit that cuts the base sheet 2A to which the base component 4 is bonded. 402, and an upper opening plate 412U and a lower opening plate 413D that sandwich the base sheet 2A to which the base component 4 is bonded. The base component fixing portion 401 has a concave portion 403 having a shape corresponding to the entire outer shape of the base component 4. In the fine projection unit 10, the concave portion 403 is formed in a shape in which the bottom portion 41 is fitted in a circular cylindrical shape, similarly to the concave portion 303 of the base component fixing portion 301 included in the member joint portion 300.

As shown in FIGS. 7 and 11, the base component fixing portion 401 has a recess 403 and is arranged on the one surface 2D (lower surface) side of the base sheet 2A. The base sheet 2A to which the base part 4 is joined is held by fitting the outer shape on the bottom 41 side. The base component fixing portion 401 may be fixed in the same manner as the base component fixing portion 301 included in the member joint portion 300. However, in the manufacturing apparatus 100, the base component fixing portion 401 is movable in a direction in which the base component fixing portion 401 abuts on the base sheet 2A. It has become. Specifically, the base component fixing portion 401 can be moved up and down in the thickness direction by an electric actuator (not shown).
The operation of the base component fixing unit 401 is controlled by a control unit (not shown) provided in the manufacturing apparatus 100.

  The base component fixing portion 401 may be made of the same material as that of the convex portion 11 or may be made of synthetic resin or the like, similar to the base component fixing portion 301 of the member joining portion 300.

  The cut part 402 is a part which manufactures the fine protrusion unit 10 by cut | disconnecting the base material sheet 2A to which the base component 4 was joined. As shown in FIGS. 7 and 11, the cut portion 402 surrounds the projection region 3 </ b> R that is a region where the projection portion 3 is formed in the base sheet 2 </ b> A, and further corresponds to the peripheral wall portion 43 of the base component 4. It has an annular tip 402s. The cut portion 402 having the tip portion 402s is formed in a cylindrical shape having an opening on the tip portion 402s side.

As shown in FIGS. 7 and 11, the cut portion 402 is disposed on the other surface 2U (upper surface) side of the base sheet 2A. In the manufacturing apparatus 100, the cut unit 402 is movable in a direction in which it is in contact with the base sheet 2 </ b> A and in a direction in which it is separated. Specifically, the cut part 402 can be moved up and down in the thickness direction by an electric actuator (not shown).
Control of the operation of the cutting unit 402 is controlled by control means (not shown) provided in the manufacturing apparatus 100.

  As a means for cutting in the cutting step, a means such as a punching blade or a laser can be cited. In the manufacturing apparatus 100, the means for cutting the cutting portion 402 is a cutting means using a punching blade. The blade of the front end portion 402 s of the cut portion 402 is preferably arranged within the range of the thickness T4 of the front end wall portion 43 s of the peripheral wall portion 43 of the base part 4. In the manufacturing apparatus 100, the blade of the distal end portion 402 s of the cut portion 402 is on the contour 4 </ b> L of the base part 4, in other words, on the protruding region 3 </ b> R side on the inner side of the outer periphery of the bottom portion 41, and outside the band-shaped joint portion 5. It is located outward from the peripheral edge. The laser is a cutting means for irradiating a laser beam to melt and bond the materials such as the base sheet 2A and the base component 4 with heat and at the same time melt and cut the base sheet 2A. .

  The lower opening plate 413D is arranged on the one surface 2D (lower surface) side of the base sheet 2A, as shown in FIG. 11, similarly to the lower opening plate 313D of the member joint portion 300, and has one opening. It is formed of a plate-like plate having a portion 413a. The opening area of the opening 413a is larger than the plane area of the base component fixing portion 401 so that the base component fixing portion 401 can be inserted when the base component fixing portion 401 is moved upward in the thickness direction from the one surface 2D side. Is formed.

  The upper opening plate 412U is arranged on the other surface 2U (upper surface) side of the base sheet 2A, as shown in FIG. 11, similarly to the upper opening plate 312U of the member joint portion 300, and has one opening. It is formed of a plate-like plate having 412a. The opening area of the opening 412a is formed larger than the flat area of the cut portion 402 so that the cut portion 402 can be inserted when the cut portion 402 is moved downward in the thickness direction from the other surface 2U side.

The lower opening plate 413D and the upper opening plate 412U are movable in a direction in which the lower opening plate 413D and the upper opening plate 412U are in contact with and away from the base sheet 2A. In the manufacturing apparatus 100, the lower opening plate 413D and the upper opening plate 412U are movable up and down in the thickness direction by an electric actuator (not shown).
Control of the operations of the lower opening plate 413D and the upper opening plate 412U is controlled by a control means (not shown) provided in the manufacturing apparatus 100.

  In the method of manufacturing the fine protrusion unit 10, as shown in FIGS. 11A and 11B, the lower opening plate 413D is moved upward and the upper opening plate 412U is moved downward to form the lower opening. Between the plate 413D and the upper opening plate 412U, the base sheet 2A to which the base component 4 is joined and the fine protrusions 1 are disposed is sandwiched at a position outside the outline 4L of the base component 4 in the base sheet 2A. . In this manner, the base sheet 2A to which the base component 4 is bonded is sandwiched between the lower opening plate 413D and the upper opening plate 412U.

  And in the manufacturing method of the fine protrusion unit 10, as shown in FIG.11 (c), in the state which pinched | interposed the base material sheet 2A with the lower side opening plate 413D and the upper side opening plate 412U, one surface 2D of the base material sheet 2A The base component fixing portion 401 is passed from the side (lower surface side). Then, the outer shape of the base part 4 on the bottom 41 side is fitted into the recess 403 of the base part fixing part 401, and the base sheet 2A to which the base part 4 is joined and the fine protrusions 1 are arranged is held.

  And as shown in FIG.11 (d), in the state which pinched | interposed the base material sheet 2A to which the base component 4 was joined by the lower side opening plate 413D and the upper side opening plate 412U, the other surface 2U of the base material sheet 2A From the side (upper surface side), the cut portion 402 is passed through the opening portion 412a of the upper opening plate 412U, and the blade of the tip portion 402s of the cut portion 402 is viewed from the fine projection tool 1 side in plan view. The fine projection unit 10 is manufactured by cutting it while being in contact with the other surface 2U of the base sheet 2A along the outline 4L inside 4L. In the cutting process of the manufacturing method of the fine protrusion unit 10, the base sheet 2A is cut on the tip wall part 43s of the peripheral wall part 43 arranged on the outer periphery of the liquid holding space 4k of the base part 4, and the fine protrusion unit 10 is removed. To manufacture.

  After performing a cutting process, as shown in FIG.11 (e), the cut part 402 is moved to the upper direction of the thickness direction from the other surface 2U side (upper surface side) of the base material sheet 2A. Then, as shown in FIG. 11 (f), the trim portion 2At of the base sheet 2A sandwiched between the lower opening plate 413D and the upper opening plate 412U is moved downward and the upper opening plate 413D is moved downward. After moving 412U upwards, remove. In this way, the fine protrusion unit 10 is formed on the base component fixing portion 401.

  Thereafter, the fine protrusion unit 10 formed as described above is taken out from the base component fixing portion 401 and conveyed downstream in the conveyance direction (Y direction). By repeating the above steps, the fine protrusion unit 10 can be manufactured continuously and efficiently.

  As mentioned above, although this invention was demonstrated based on the preferable embodiment, this invention is not restrict | limited to the said embodiment, It can change suitably.

  For example, the microprojection unit 10 shown in FIGS. 1 to 3 described above has a configuration as shown in FIGS. 12A to 12D when viewed from the microprojection tool 1 in plan view. It may be 10. Specifically, in the microprojection unit 10 shown in FIG. 12A, the outline 4L of the base part 4 is circular, and three rows in the vertical direction Y and three rows in the horizontal direction X on the upper surface of the sheet-like base 2. Nine protrusions 3 are arranged in three rows. According to the fine protrusion unit 10 shown in FIG. 12A, the same effects as those of the fine protrusion unit 10 shown in FIGS. Further, in the fine protrusion unit 10 shown in FIG. 12B, the outline 4L of the base part 4 has a circular shape, and one protrusion 3 is arranged on the upper surface of the sheet-like base 2 at the center of the outline 4L. In addition, a plurality of protrusions 3 are arranged at intervals on a plurality of concentric circles extending from the one protrusion 3, and a total of 21 protrusions 3 are provided. According to the fine protrusion unit 10 shown in FIG. 12B, the protrusion 3 is arranged on the concentric circle, so that the puncture property is further improved.

  Further, in the microprojection unit 10 shown in FIG. 12C, the outline 4L of the base component 4 has an oval shape, and is spaced on the upper surface of the sheet-like base 2 along the direction in which the oval shape extends. The five protrusions 3 are arranged in one row. According to the fine protrusion unit 10 shown in FIG. 12 (c), since the protrusions 3 are arranged in one row, the puncture property is further improved. Further, in the fine protrusion unit 10 shown in FIG. 12 (d), the outline 4L of the base component 4 is a rectangular quadrilateral, five rows in the vertical direction Y and five rows in the horizontal direction X on the upper surface of the sheet-like base 2. Twenty-five protrusions 3 are arranged in five rows. According to the fine protrusion unit 10 shown in FIG. 12D, the same effects as those of the fine protrusion unit 10 shown in FIGS. In addition, the outline 4L shape of the base part 4 may be a polygon such as a rhombus or a triangle other than the rectangular quadrilateral.

In relation to the above-described embodiment, the present invention further discloses the following fine protrusion unit.
<1>
A fine projection having a hollow protrusion on the base, and a base component having a liquid holding space communicating with the inside of the protrusion through the base, and the fine protrusion at the tip of the base component In the joined microprojection unit, when a liquid is injected into the liquid holding space of the base component and an internal pressure is applied, a region having the projection on the base of the microprojection protrudes outward. A micro-projection unit that curves into
<2>
When the microprojection unit is viewed in cross-section along the thickness direction, the base thickness of the microprojection tool is the length of the base component in the thickness direction at the joint where the base component and the microprojection tool are joined. The fine protrusion unit according to <1>, which is smaller than the above.
<3>
The base component has a bottom portion surrounding the liquid holding space, and a peripheral wall portion arranged over the entire outer periphery of the bottom portion, and the thickness at the bottom portion is thicker than the thickness of the base, The fine protrusion unit according to <1> or <2>.
<4>
The fine protrusion unit according to <3>, wherein a thickness of the peripheral wall portion is larger than a thickness of the base.
<5>
<1> to <4, wherein the fine projection tool has an opening at the tip side, and a space penetrating from the base to the opening is formed inside the protrusion. > The fine projection unit according to any one of the above.
<6>
The protrusion has a protrusion height of preferably 0.01 mm or more, more preferably 0.02 mm or more, and preferably 10 mm or less, more preferably 5 mm or less, and still more preferably 3 mm. Specifically, it is preferably 0.01 mm or more and 10 mm or less, more preferably 0.01 mm or more and 5 mm or less, and still more preferably 0.02 mm or more and 3 mm or less. 5> The fine projection unit according to any one of 5>.
<7>
The protrusion has an average thickness of preferably 0.005 mm or more, more preferably 0.01 mm or more, and preferably 1.0 mm or less, more preferably 0.5 mm or less. The fine protrusion unit according to any one of <1> to <6>, which is preferably 0.005 mm to 1.0 mm, and more preferably 0.01 mm to 0.5 mm.
<8>
The tip diameter of the protrusion is preferably 0.001 mm or more, more preferably 0.005 mm or more, and preferably 0.5 mm or less, more preferably 0.3 mm or less, Specifically, the fine protrusion unit according to any one of <1> to <7>, preferably 0.001 mm to 0.5 mm, and more preferably 0.005 mm to 0.3 mm. .
<9>
The fine protrusion has an opening on the tip side, and the opening has an opening area of preferably 0.7 μm ² or more, more preferably 20 μm ² or more, and preferably at 200000Myuemu ² or less, still more preferably not more 70000Myuemu ² or less, particularly preferably not 0.7 [mu] m ² or more 200000Myuemu ² or less, further wherein preferably at 20 [mu] m ² or more 70000Myuemu ² or less <1> The fine protrusion unit according to any one of ~ <8>.
<10>
The ratio of the base thickness T2 to the thickness T3 at the bottom of the base component (T2 / T3) is preferably 0.001 or more, more preferably 0.01 or more, and preferably 1 or less, Preferably it is 0.5 or less, Preferably it is 0.001 or more and 1 or less, More preferably, it is 0.01 or more and 0.5 or less, It is described in any one of said <1>-<9>. Fine projection unit.
<11>
The thickness of the base is preferably 0.01 mm or more, more preferably 0.02 mm or more, and preferably 1.0 mm or less, more preferably 0.7 mm or less, specifically preferably Is a fine protrusion unit according to any one of <1> to <10>, which is 0.01 mm or more and 1.0 mm or less, and more preferably 0.02 mm or more and 0.7 mm or less.
<12>
The base part has a bottom part surrounding the liquid holding space and a peripheral wall part arranged over the entire outer periphery of the bottom part, and the thickness of the base part at the bottom part is preferably 1.0 mm. Above, more preferably 1.5 mm or more, and preferably 10 mm or less, more preferably 5 mm or less, specifically preferably 1.0 mm or more and 10 mm or less, more preferably 1. The fine projection unit according to any one of <1> to <11>, which is 5 mm to 5 mm.
<13>
The base part has a bottom part surrounding the liquid holding space and a peripheral wall part arranged over the entire outer periphery of the bottom part, and the thickness of the base part in the peripheral wall part is preferably 1. It is 0 mm or more, more preferably 1.5 mm or more, and preferably 10 mm or less, more preferably 5 mm or less, specifically preferably 1.0 mm or more and 10 mm or less, more preferably 1 The fine projection unit according to any one of <1> to <12>, which is 5 mm or more and 5 mm or less.
<14>
A cross-sectional view of the microprojection unit along the thickness direction, and at the joint where the base component and the microprojection device are joined, the base thickness T2 of the microprojection tool with respect to the length L1 in the thickness direction of the base component The ratio (T2 / L1) is preferably 0.005 or more, more preferably 0.01 or more, and preferably 0.5 or less, more preferably 0.3 or less, and preferably The fine protrusion unit according to any one of <1> to <13>, which is 0.005 or more and 0.5 or less, and more preferably 0.01 or more and 0.3 or less.
<15>
The length in the thickness direction of the base part is preferably 2 mm or more, more preferably 3 mm or more, and preferably 20 mm or less, more preferably 15 mm or less, specifically, preferably 2 mm or more. The fine protrusion unit according to any one of <1> to <14>, which is 20 mm or less, more preferably 3 mm or more and 15 mm or less.
<16>
The outline of the base of the microprojection tool is preferably 0.05 mm or more, more preferably 0.1 mm or more, and preferably 5 mm or less, more preferably 3 mm or less, inward from the outline of the base component. The microprojection unit according to any one of <1> to <15>, preferably 0.05 mm to 5 mm, more preferably 0.1 mm to 3 mm, with an interval.
<17>
In the microprojection unit, the base component and the microprojection tool are joined by a belt-like joint, and the width of the belt-like joint is preferably 0.5 mm or more, more preferably 1 mm or more, and Preferably it is 5 mm or less, More preferably, it is 3 mm or less, Specifically, Preferably it is 0.5 mm or more and 5 mm or less, More preferably, it is 1 mm or more and 3 mm or less, Any one of said <1>-<16>. Fine projection unit.
<18>
In the microprojection unit, the base component and the microprojection tool are joined by a band-shaped joint portion, and the interval between the outline of the base and the outer peripheral edge of the joint portion is preferably 0.05 mm or more, More preferably, it is 0.1 mm or more, and preferably 5 mm or less, more preferably 3 mm or less, specifically, preferably 0.05 mm or more and 5 mm or less, more preferably 0.1 mm or more and 3 mm or less, with an interval. The fine protrusion unit according to any one of <1> to <17>.
<19>
The base part has a bottom part surrounding the liquid holding space, and a peripheral wall part arranged over the entire outer periphery of the bottom part, and the base part and the fine protrusions are band-shaped joint parts. In the fine protrusion unit, the distance between the peripheral edge on the protrusion region 3R side on the inner side of the joint portion and the inner wall of the tip wall portion of the peripheral wall portion is preferably 0.05 mm or more, and more preferably 0. .1 mm or more, and preferably 5 mm or less, more preferably 3 mm or less, more preferably 0.05 mm or more and 5 mm or less, more preferably 0.1 mm or more and 3 mm or less, with a space between them. The fine projection unit according to any one of <1> to <18>.

DESCRIPTION OF SYMBOLS 10 Fine protrusion unit 1 Fine protrusion tool 2 Base 2A Base material sheet 2At Trim part 3 Protrusion part 3R Protrusion area 4 Base part 4k Liquid holding space 4L Outline of base part 41 Bottom part 42 Liquid supply path 43 Peripheral wall part 43s Tip wall part 100 Manufacture Device 200 Fine projection forming part 210 Projection part forming part 11 Convex part 110 Convex type 12U Opening plate 13D Second opening plate 220 Cooling part 230 Release part 300 Member joint part 301 Base component fixing part 302 Joint part 312U Upper opening plate 313D Lower opening plate 303 Recess 400 Member cut part 401 Base part fixing part 402 Cut part 412U Upper opening plate 413D Lower opening plate 403 Recess

Claims (5)

A fine projection having a hollow protrusion on the base, and a base component having a liquid holding space communicating with the inside of the protrusion through the base, and the fine protrusion at the tip of the base component A joined micro-projection unit,
A microprojection unit, wherein when a liquid is injected into the liquid holding space of the base component and an internal pressure is applied, a region having the projection on the base of the microprojection is curved outwardly. A cross-sectional view of the fine protrusion unit along the thickness direction,
2. The microprojection unit according to claim 1, wherein a thickness of the base of the microprojection tool is smaller than a length of the base component in a thickness direction at a joint portion where the base component and the microprojection tool are joined. The base component has a bottom portion surrounding the liquid holding space, and a peripheral wall portion arranged over the entire outer periphery of the bottom portion,
The fine protrusion unit according to claim 1 or 2, wherein a thickness at the bottom is thicker than a thickness of the base.   The fine projection unit according to claim 3, wherein a thickness of the peripheral wall portion is larger than a thickness of the base.   The base part has a bottom part surrounding the liquid holding space and a peripheral wall part arranged over the entire outer periphery of the bottom part, and the fine protrusion tool on an upper surface of the peripheral wall part facing the fine protrusion tool. 5. The microprojection unit according to claim 1, further comprising a non-joining region that is not joined to the microprojection tool on the liquid holding space side of the upper surface.