JP2018199726A5 - - Google Patents

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Publication number
JP2018199726A5
JP2018199726A5 JP2018179866A JP2018179866A JP2018199726A5 JP 2018199726 A5 JP2018199726 A5 JP 2018199726A5 JP 2018179866 A JP2018179866 A JP 2018179866A JP 2018179866 A JP2018179866 A JP 2018179866A JP 2018199726 A5 JP2018199726 A5 JP 2018199726A5
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JP
Japan
Prior art keywords
abraxane
medicament
plinabulin
medicament according
administration
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Pending
Application number
JP2018179866A
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Japanese (ja)
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JP2018199726A (en
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Priority to JP2018179866A priority Critical patent/JP2018199726A/en
Priority claimed from JP2018179866A external-priority patent/JP2018199726A/en
Publication of JP2018199726A publication Critical patent/JP2018199726A/en
Publication of JP2018199726A5 publication Critical patent/JP2018199726A5/ja
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Claims (14)

プリナブリンの構造を有する化合物を含む医薬であって、前記医薬がアブラキサンと組み合わせて使用される、がん治療のための医薬。A medicament comprising a compound having a plinabulin structure, wherein the medicament is used in combination with Abraxane. アブラキサン投与の少なくとも1時間後に投与される、請求項1に記載の医薬。The medicament according to claim 1, which is administered at least 1 hour after the administration of Abraxane. 10〜50mg/m10-50mg / m 2 (体表面積)の用量でプリナブリンを含む、請求項1又は2に記載の医薬。The medicament according to claim 1 or 2, comprising plinabulin at a dose of (body surface area). 20mg/m20 mg / m 2 (体表面積)又は30mg/m(Body surface area) or 30 mg / m 2 (体表面積)の用量でプリナブリンを含む、請求項3に記載の医薬。The medicament according to claim 3, comprising plinabulin at a dose of (body surface area). アブラキサン投与量とプリナブリン投与量の質量比が1.5:1〜4:1である、請求項1又は2に記載の医薬。The medicine according to claim 1 or 2, wherein the mass ratio of the Abraxane dose to the plinabulin dose is 1.5: 1 to 4: 1. アブラキサン投与前に投与される、請求項1に記載の医薬。The medicament according to claim 1, which is administered before Abraxane administration. アブラキサン投与後に投与される、請求項1に記載の医薬。The medicament according to claim 1, which is administered after Abraxane administration. プリナブリンが、アブラキサン投与の0.5〜72時間後に投与される、請求項1又は2に記載の医薬。The medicament according to claim 1 or 2, wherein plinabulin is administered 0.5 to 72 hours after the administration of Abraxane. プリナブリンが、アブラキサン投与の0.5〜24時間後に投与される、請求項1又は2に記載の医薬。The medicament according to claim 1 or 2, wherein plinabulin is administered 0.5 to 24 hours after Abraxane administration. 前記がんが、肺がん、結腸がん、胃がん、肝がん、乳がん、前立腺がん、及び多発性骨髄腫からなる群から選択される、請求項1又は2に記載の医薬。The medicament according to claim 1 or 2, wherein the cancer is selected from the group consisting of lung cancer, colon cancer, stomach cancer, liver cancer, breast cancer, prostate cancer, and multiple myeloma. プリナブリンの構造を有する化合物を含む医薬であって、3cm以上の大きさの腫瘍を有する対象において、前記医薬がアブラキサンと組み合わせて使用される、がん治療のための医薬。A medicament for treating cancer, comprising a compound having a plinabulin structure, wherein the medicament is used in combination with Abraxane in a subject having a tumor having a size of 3 cm or more. アブラキサン投与の少なくとも1時間後に投与される、請求項11に記載の医薬。The medicament according to claim 11, which is administered at least 1 hour after the administration of Abraxane. 前記対象が、5cm以上の大きさの腫瘍を有する対象である、請求項11又は12に記載の医薬。The medicine according to claim 11 or 12, wherein the subject is a subject having a tumor having a size of 5 cm or more. 前記対象が、7cm以上の大きさの腫瘍を有する対象である、請求項11又は12に記載の医薬。The medicament according to claim 11 or 12, wherein the subject is a subject having a tumor having a size of 7 cm or more.
JP2018179866A 2018-09-26 2018-09-26 Cancer treatment with combination of plinabulin and taxane Pending JP2018199726A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2018179866A JP2018199726A (en) 2018-09-26 2018-09-26 Cancer treatment with combination of plinabulin and taxane

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2018179866A JP2018199726A (en) 2018-09-26 2018-09-26 Cancer treatment with combination of plinabulin and taxane

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2016547208A Division JP6411523B2 (en) 2013-10-11 2013-10-11 Combination cancer treatment of plinabulin and taxane

Publications (2)

Publication Number Publication Date
JP2018199726A JP2018199726A (en) 2018-12-20
JP2018199726A5 true JP2018199726A5 (en) 2019-03-14

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Family Applications (1)

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JP2018179866A Pending JP2018199726A (en) 2018-09-26 2018-09-26 Cancer treatment with combination of plinabulin and taxane

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JP (1) JP2018199726A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022552011A (en) * 2019-10-15 2022-12-14 ビヨンドスプリング ファーマシューティカルズ,インコーポレイテッド Methods and compositions for treating iron disorders

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1711487A1 (en) * 2004-02-04 2006-10-18 Nereus Pharmaceuticals, Inc. Dehydrophenylahistins and analogs thereof and the synthesis of dehydrophenylahistins and analogs thereof
CA2683973A1 (en) * 2007-04-13 2008-10-23 Abraxis Bioscience, Inc. Sparc and methods of use thereof
WO2015051543A1 (en) * 2013-10-11 2015-04-16 Dalian Wanchun Biotechnology Co., Ltd. Cancer treatment with combination of plinabulin and taxane

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