JP2018153649A - Method for increasing blood flow - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a method for increasing a blood flow, which improves symptoms such as mental stress by increasing the blood flow.SOLUTION: On specific sites of the body such as at least two sites on the soles of right and left feet having sites intersecting with inner malleoli on an extension of an inside border between first and second toes, a blood flow is measured before the application of heat stimulation; a rate of increase in the blood flow before to after the application of the stimulus to the specific sites is calculated; and the heat stimulation is applied so that the rate of increase in the blood flow before to after the application of the stimulus can be 30% or more.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a method for increasing blood flow on a body surface in order to improve a medical condition such as mental stress.

  As a conventional technique, Patent Document 1 includes a blood flow measurement unit that measures blood flow in a predetermined part of the body, and a blood flow promotion unit that promotes blood flow by applying stimulation to the predetermined part of the body. Disclosed is a blood flow promoting device in which the blood flow measuring unit and the blood flow promoting unit are provided on a surface corresponding to a predetermined site, and the blood flow promoting unit promotes blood flow at a predetermined site measured by the blood flow measuring unit. Has been.

JP 2012-5595 A

  Patent Document 1 discloses a blood flow promoting device that promotes blood flow by a blood flow promoting unit at a predetermined part of the body measured by the blood flow measuring unit. Although it is recognized that blood flow can be promoted, the rate of change or increase in blood flow or the peak temperature of the body surface is specified as to how blood flow is increased in response to medical conditions such as mental stress. Therefore, the present invention aims to increase blood flow appropriately according to the medical condition such as mental stress by specifying these specific data. is there.

  The present invention is a method of increasing blood flow by applying thermal stimulation to a specific part of the body surface, measuring the blood flow before applying thermal stimulation to the specific part, and then applying thermal stimulation to the specific part The blood flow rate after application is measured to determine the rate of increase of the blood flow rate before and after applying the thermal stimulation to the specific site, where the increase in the blood flow rate is the laser Doppler tissue attached to the center of the wrist joint striation This method proposes a method of measuring blood flow using a blood flow meter and applying thermal stimulation so that the rate of increase in blood flow before and after applying the stimulus is 30% or more to increase the blood flow. is there.

    Further, the present invention is a method for increasing a blood flow rate by applying a thermal stimulus to the body surface via a stimulating conductor provided in contact with at least two different specific sites on the body surface, The thermal stimulation conductor is brought into contact with at least two specific sites on the body surface so that the rate of increase in blood flow before and after the thermal stimulation is applied is 30% or more. A thermal stimulus up to 50 ° C ± 5 ° C is applied to the body surface through the body, where the increase in blood flow is measured using a laser Doppler tissue blood flow meter attached to the center of the wrist joint striation A method for increasing the blood flow is also proposed.

  Furthermore, the present invention is characterized in that, in the above-mentioned direction of the present invention, the specific parts are at least two parts including a part intersecting a perpendicular line of the inner collar on an extension line of the inner edge between the first and second fingers. It is what.

As a specific method in the present invention, the blood flow is measured with a laser Doppler tissue blood flow meter attached to the inner center of the wrist joint before and after applying the thermal stimulation to the selected specific site for applying the thermal stimulation, Obtain the rate of change before and after applying the stimulus from the blood flow,
The rate of change before and after applying the stimulus is compared with the rate of change of a database in which the rate of change effective for the medical condition is stored in advance. Here, the measured rate of change is 30% or more, preferably 200% or more. Compare with the rate of change of the stored database,
If the measured rate of change in blood flow before and after the stimulus is equal to or greater than the rate of change in blood flow in the database that stores the rate of change in blood flow that has an effect on the medical condition in advance, the drug is supplied into the body, Compared with the improvement of the medical condition after the thermal stimulation is given, if the drug is further effective due to the supply of the drug into the body compared to the improvement of the medical condition after the stimulation, the drug is evaluated as a drug effective for the medical condition. If the drug is not effective due to the supply of the drug to the body, the drug is evaluated as having no effect on the medical condition, and if it is determined that the drug is not effective, the amount of the drug is changed and / or an alternative drug. Is used to evaluate the efficacy of the drug.

  According to the method of the present invention, the blood flow before applying a thermal stimulus to a specific site is measured, and then the blood flow after the thermal stimulus is applied to the specific site is measured to apply the thermal stimulus to the specific site. The increase rate of the blood flow before and after the blood flow is obtained by measuring the blood flow using a laser Doppler tissue blood flow meter attached to the central part of the wrist joint striation and before and after applying the stimulus. By applying thermal stimulation so that the rate of increase in blood flow is 30% or more, the blood flow is increased, thereby improving medical conditions such as mental stress.

Also, to increase blood flow, at least two different places on the body surface, for example
Giving thermal stimulation to the body surface via a stimulating conductor provided in contact with a specific part such as a part that intersects the perpendicular of the inner collar on the extension line of the inner edge between the first and second fingers,
Applying a thermal stimulus up to 50 ° C. ± 5 ° C. at a peak temperature on the body surface through the thermal stimulation lead so that the rate of increase in blood flow before and after the application of the thermal stimulus is 30% or more;
Increases blood flow by measuring the increase in blood flow using a laser Doppler tissue blood flow meter attached to the center of the wrist joint striation, thereby further increasing the pathological conditions such as mental stress Can be improved.

It is the schematic which shows the irritation | stimulation site | part of a sole. It is a database which shows the change rate of the blood flow rate of a specific part. It is a database which shows the change rate of the blood flow rate in a medical condition. It is a database which shows the change rate of the blood flow rate of 11 patients. It is the schematic which shows the electric thermal stimulation apparatus used for this invention. It is the schematic of the circuit diagram of an electrical thermal stimulation apparatus. It is the schematic which shows arrangement | positioning of the function of the electrical thermal stimulation apparatus used for this invention. It is the schematic which shows the cycle of the heat stimulation waveform and heat stimulation waveform which are obtained by controlling an electric thermal stimulation apparatus. It is the schematic which shows the heat stimulation protocol to the irritation | stimulation site | part of a sole. It is a database which shows the change rate of the blood flow rate of nine patients.

  About the thermal stimulation transmission evaluation method for evaluating the thermal stimulation given to the specific part of the skin surface by controlling the electric thermal stimulation device to treat the medical condition such as mental stress and the drug efficacy evaluation method by thermal stimulation transmission ,explain.

The thermal stimulus transmission evaluation method includes the following steps.
(Step 1) A step of examining a medical condition such as mental stress.
The examination items for examining the pathological conditions such as mental stress are the blood pressure, deep body temperature, salivary amylase immediately before stimulation after the subject is rested in the supine position for 20 minutes in consideration of the influence on the mental stress via the autonomic nerve. , Heart rater (arterial age), etc.

  Changes in blood flow are compared by comparing the rate of change in blood flow obtained by measuring before and after applying a stimulus to a specific site with the rate of change in blood flow in a database that contains the rate of change in blood flow that was found to be effective in the disease state. Thermal stimulation is evaluated based on the difference in rate.

  Here, the blood flow is preferably measured with a laser Doppler tissue blood flow meter attached to the inner central part of the wrist joint. The laser doppler tissue blood flow meter ALF21D (manufactured by Adovans) converts the reflected light from the tissue when it is irradiated with semiconductor laser light (wavelength 780nm) into an electrical signal and processes it. Get flow information. Using this laser tissue blood flow meter ALF21D, a C-type laser probe (diameter 10mm, thickness 3mm, laser irradiation area 2mm, measurement depth 1mm) was attached to the center of the striated joint of a healthy adult, and rested 15 minutes after stimulation The rate of change in blood flow was measured.

  When evaluating thermal stimulation, the electric thermal stimulation control device incorporated in the electric thermal stimulation device is driven, and at least one of the stimulation temperature, the stimulation time, the stimulation method, the thermal stimulation pattern, and the thermal stimulation condition is reduced. It is preferable to change the blood flow rate and compare the change rate of the blood flow rate by supplying a stimulus to the site. Thereby, the evaluation of the stimulus is appropriately performed with higher accuracy.

Thermal stimulation is evaluated based on the difference between the two rates of change.
The rate of change obtained before and after applying the stimulus is compared with the rate of change of the database that stores the rate of change effective for the medical condition in advance. Thermal stimulation is evaluated by comparing the rate of change between the two. Here, the rate of change obtained in advance for the medical condition is compared with the rate of change obtained by applying the stimulus, and the rate of change obtained by the stimulation is approximately the same as the rate of change previously effective for the medical condition. If it is more than that, it is judged that the effect of the stimulus was recognized.

  When the rate of change obtained by stimulation is smaller than the rate of change effective for the medical condition in advance, the electrical thermal stimulation control device incorporated in the electrical thermal stimulation device described above is driven, the stimulation temperature, and the stimulation time. It is preferable to change at least one of the method of applying the stimulus, the thermal stimulation pattern, and the thermal stimulation condition, apply the stimulation to the part again, and obtain the increase rate of the blood flow rate, and compare them.

  The present inventor has found that increasing the rate of change in blood flow as much as possible is effective for various medical conditions. In the following (Step 3), the rate of change in blood flow when heat stimulation was applied to a specific site;

  This stimulation method (step 2) was found to be effective to give a thermal stimulus to the following specific site newly found before applying thermal stimulation to the specific site in the following (step 3). The thermal stimulation is preferably given by an electric thermal stimulation control device or a basket.

(Step 2) This stimulation method is achieved by applying thermal stimulation to the following specific site. (I) Stimulation to the left pond and the center. The abdominal cavity environment is prepared by this stimulation.
(ii) Stimulation of the foot's Sanri and Terumi. In addition to adjusting digestive organs and kidney function, this stimulation also regulates the whole body.
Here, how to give thermal stimulation is as follows.
(I) Set the electric thermal stimulation control device on the left pond / medium and stimulate for 10 minutes. In this case, a gold conductor is attached to the left pond and an aluminum conductor is attached to the center.
(ii) Set Sanri and Terumi of the left and right feet and stimulate for 10 minutes using the electrical thermal stimulation control device. In this case, a gold conductor is attached to the left and an aluminum conductor is attached to the right.

  By performing this stimulation method described above, the change rate of the blood flow rate is 200% or more, preferably 300% or more based on the patient data shown in FIG.

(Step 3) A step of selecting a specific part for giving thermal stimulation.
As shown in FIG. 1, the specific part is (i) a part between the first and second metatarsal heads on the left and right soles, (ii) a part between the second and third finger metatarsal heads, and (iii) It is preferable that it is at least one of the part which cross | intersects the perpendicular of an inner collar on the extension line of an inner edge between 1st and 2nd.

  That is, a thermal stimulus is given to the selected specific part of FIG. Then, the blood flow rate is measured with a laser Doppler tissue blood flow meter attached to the inner central part of the wrist joint before and after the thermal stimulation is applied, and the rate of change before and after the stimulation is obtained. Here, the blood flow rate is measured with a laser Doppler tissue blood flow meter attached to the center of the wrist joint. The change rate of the blood flow rate is obtained before and after applying the stimulus, and the change rate before and after applying the stimulus is compared with the change rate of the database that stores the change rate effective for the medical condition in advance.

(Step 4) Furthermore, the inventor has found that it is more effective to carry out the following processing in order to exert an effect on the medical condition more.
Step 5 is a step of applying a thermal stimulus to a visceral body wall reflection point, which is a point peculiar to a disease state, or a known so-called “acupuncture point” known to be effective for a disease state.

  The electrical thermal stimulation control device includes a blood flow database that is recognized as having an effect on a medical condition. The change rate of the blood flow obtained by measuring before and after the stimulation is compared with the change rate of the blood flow in the database. A database of blood flow recognized as having an effect on a medical condition is shown in FIGS. FIG. 2 shows the rate of change of blood flow at the stimulation site of FIG. In the table, (i) the first and second finger metatarsal region (A) on the left and right soles, (ii) the second and third metatarsal region (B), (iii) first It is preferable that it is at least one of the site | part (F) and A + F combination site | part which cross | intersect the perpendicular line of an inner collar on the extension line of an inner edge between 2nd and 2nd. In A, the change rate of the blood flow rate is +1.30 or more, in B, the change rate of the blood flow rate is +1.30 or more, in F, the change rate of the blood flow rate is +1.30 or more, and in A + F, the change rate of the blood flow rate. Gets +1.40 or more.

  FIG. 3 is a database showing the rate of change of blood flow in a medical condition. As an example of the medical condition, the rate of change of blood flow in excessive stress, cardiac dysfunction, and weak constitution is shown. The rate of change in blood flow is +1.4 or higher due to excessive stress, the rate of change in cardiac dysfunction is +1.6 or higher, and the rate of change in frailty is +1.7 or higher.

  FIG. 4 is a database showing the change rate of blood flow of 11 patients. The effect was recognized when the change rate was +1.6 or more.

(Step 5) In the thermal stimulation evaluation, the Tanda breathing method may be further performed.
Tanda is about a fist down from the navel. Tanda breathing is performed by inflating the lower abdomen with slow breathing, which lowers the diaphragm and further expands the chest cavity, allowing greater breathing. This large breathing takes a slow interval to concentrate your consciousness on the breath you breathe and breathe, and make your head empty (innocent). Thereby, the autonomic nerve which has been disturbed by stress can be arranged.

  Next, it is preferable that the method for evaluating the efficacy of the drug by heat stimulus transmission is as follows.

The blood flow is measured with a laser Doppler tissue blood flow meter attached to the inner center of the wrist joint before and after applying the thermal stimulation to the selected specific site for applying the thermal stimulation, and before and after applying the stimulus from the blood flow Finding the rate of change, comparing the rate of change before and after applying the stimulus with the rate of change of the database storing the rate of change effective against the medical condition in advance,
Here, the change rate is compared with the change rate of the stored database at 30% or more, preferably 200% or more.

  When the rate of change in blood flow before and after the application of the stimulus is equal to or higher than the rate of change in blood flow in a database that stores in advance the rate of change in blood flow that is effective for a medical condition, the drug is supplied into the body.

  When a further effect of the drug is recognized by supply of the drug into the body as compared with the improvement of the medical condition after application of the heat stimulus, the drug is evaluated as a drug effective for the medical condition.

  When there is no further effect of the drug due to the supply of the drug to the body compared to the improvement of the medical condition after the thermal stimulus is given, the drug is evaluated as having no effect on the medical condition, and it is determined that the drug is not effective Change the amount of drug and / or supply an alternative drug to reevaluate the utility of the drug.

  The database which shows the change rate of the blood flow volume recognized as having an effect on the medical condition is shown in FIGS.

  FIG. 5 is a schematic view showing an electric thermal stimulation apparatus used in the present invention. FIG. 6 shows a schematic diagram of a circuit diagram of the electrical thermal stimulation apparatus.

  The electrical thermal stimulation device includes a device main body 10 incorporating a control function, and a thermal stimulation conductor 14 connected to the device main body 10 by a conducting wire 12. As shown in FIG. 5, the apparatus main body 10 includes a storage unit 16 that stores a heating stimulation pattern, a control unit (CPU) 18 that reads the heating stimulation pattern from the storage unit 16, and a thermal stimulation conductor 14. Output means 20 for supplying a warming stimulation pattern is provided. Thermal stimulation is introduced into the site according to the warming stimulation pattern mode.

  The control means (CPU) 18 is connected to the storage means 16. The storage means 16 stores a thermal stimulation pattern for obtaining a stimulation level equivalent to burning of soot. The control means (CPU) 18 reads the thermal stimulation pattern from the storage means 16, controls the output to the heating element based on the detection of the temperature sensor 22, and outputs the thermal stimulation pattern to the thermal stimulation conductor.

  The apparatus main body 10 is connected to a plurality of thermal stimulation conductors for supplying thermal stimulation patterns to at least two different parts described above. Thus, the selected thermal stimulation pattern is supplied to the above-described site via the thermal stimulation conductor.

  The temperature sensor 22 is provided at a position having a correlation with the affected part temperature in the vicinity of the heating element. The thermal stimulation conductor has the following structure. The thermal stimulation conductor 14 is provided on a casing constituting the apparatus main body, a heater serving as a heat source for applying thermal stimulation in the casing, and a lower surface of the casing for transmitting the heat of the heater to the skin of the user. And a sealing plate provided on the upper surface of the casing.

  In the thermal stimulation conductor, the thermal conduction plate of the thermal stimulation conductor placed at each of two locations is composed of at least two different metals. In this example, aluminum and platinum were used.

  The temperature sensor is provided at a predetermined position of the housing that is in contact with a part of the human body, detects the temperature at that position, and provides a detection signal to the sensor amplifier. The control means (CPU) controls the output of the power generation circuit so that the temperature at which the skin surface contacts the human body does not exceed a predetermined temperature.

  When the heating temperature of the heating element detected by the temperature sensor is below the desired reference temperature, control is performed so that the positive period of the pulse signal is lengthened and the negative period is shortened according to the output of the temperature sensor. Conversely, in the temperature state, control is performed so that the positive period is shortened and the negative period is lengthened.

The thermal control operation of the electrical thermal stimulator will be described below.
The case where a thermal conductor is fixed to two places of the thermal stimulation site | part mentioned above is demonstrated. Fix the two thermal conductors at the two selected sites and turn on the thermal stimulation site device. Here, the setting of the temperature of the thermal conductor and the way of applying the stimulus will be described with reference to FIG. Thermal conductors 1 and 2 are used. Adjust the temperature with the temperature setting switch. Each time the switch is pressed, the temperature is controlled from 46.5 ° C. to 52.5 ° C. in the order of 1-2-3-4-5.

  A mode selection button having a mode selection function for selecting an alternate mode / sequential mode as a heating mode is provided. In the alternate mode, the two thermal conductors 1 and 2 repeat heating and pause alternately. In the sequential mode, the two thermal conductors repeat heating one by one in order. Thus, warming (heat) is supplied to two different sites independently of each other simultaneously. To heat (heat) the four parts, four thermal conductors are used. In addition, an interval (time) mode of the heating interval can be selected. Select the alternate mode, and then select the interval (time) mode “Short / Medium / Long”. For example, in the alternating mode and short, the thermal conductors 1 and 2 are paused 5 seconds after being heated alternately (10 seconds in the middle and 15 seconds in the long). In the sequential mode and short, the thermal conductors 1 and 2 are sequentially heated at intervals of 7.5 seconds.

  FIG. 8 shows an outline of the thermal stimulation pattern. This thermal stimulation pattern is read out from the control device and used. The read thermal stimulation pattern includes the following thermal stimulation patterns. That is, the formed thermal stimulation pattern includes a thermal stimulation waveform 8 and an interval 7. The thermal stimulation waveform includes a heating peak 2 obtained by heating the temperature to a predetermined peak temperature; 50 ± 5 ° C., and a peak. And a heat radiation waveform 3 formed by turning off the heating when the temperature is reached.

  The thermal stimulation intensity may vary the thermal stimulation area. The thermal stimulation intensity increases the heating area, increases the peak temperature, increases the rising slope of the heating waveform, decreases the area of the heat dissipation area, decreases the falling slope of the heat dissipation line, and shortens the interval time. Furthermore, this is achieved by lengthening the time of the thermal stimulation pattern.

  The thermal stimulation pattern comprises independent thermal stimulation waveforms out of phase that do not substantially overlap each other. And it supplies to the at least two specific site | parts selected according to the medical condition non-simultaneously mutually independently.

  That is, the first thermal stimulation pattern includes a thermal stimulation waveform including a heating waveform curve and a heat radiation waveform as one cycle as described above, and an interval to the next heating waveform. The second thermal stimulation pattern has a thermal stimulation waveform at a predetermined time in the interval of the first thermal stimulation pattern.

  The cycle of the thermal stimulation pattern is preferably repeated for 10 to 15 minutes. When the cycle of the thermal stimulation pattern is repeated for 10 minutes to 15 minutes, it is preferable to pause for 10 minutes and then repeat the cycle of the thermal stimulation pattern again for 10 minutes to 15 minutes.

  The thermal stimulation waveform and the thermal stimulation pattern are stored in a memory in the electric thermal stimulation control device.

  In the following examples, thermal stimulation was performed using an electrical thermal stimulator manufactured by Bestec as the electrical thermal stimulator described above. The following protocol in use is shown in FIG.

  This is done by applying a thermal stimulation conductor connected to the electrical thermal stimulation device to a specific part. The thermal stimulation conductor was set to perform thermal stimulation with a diameter of 10 mm and a peak temperature of 50 ± 5 ° C. Subjects were healthy adult men and women.

  The stimulation site is (i) the region between the first and second metatarsal heads of the left and right soles, (ii) the region between the second and third metatarsal heads, and (iii) the medial region between the first and second sites. It is preferable that it is at least one of the portions intersecting with the vertical line of the inner collar on the extended line of the edge.

  The rate of change effective for the medical condition previously stored in the database shown in FIGS. 2 to 4 is recognized as effective for the following medical conditions.

1. Thermal stimulation to the site of improvement of stress (significant parasympathetic nerve) (from deep temperature, stress index, systolic blood pressure).
There was an increase in deep body temperature at all sites tested in this experiment. In particular, an increase of 2.0625 ° C was observed before and after stimulation, especially between the 2nd and 3rd metatarsal heads.
Salivary amylase is one of the indices to evaluate stress, and showed a tendency to increase before and after stimulation on the extension line between the first and second fingers and at the plantar transition part where a perpendicular line was drawn on the incarnate. It was also suggested that cortisol decreased at the same site.
A large decrease in systolic blood pressure was observed between the first and second metatarsal heads.
2. Heat stimulation to the site of liver function improvement The liver function tended to be improved by stimulating the transitional area of the plantar surface with the perpendicular line between the first and second fingers and the internal capsule.
3. Thermal stimulation of arteriosclerosis-prevented sites It was suggested that thermal stimulation between the first and second metatarsal heads further decreased (arterial effect prevention).
4). It was confirmed that the blood glucose level decreased between 5.00 and 5.33 between the first and second metatarsal heads and between the second and third metatarsal heads.
5. Thermal stimulation of the intestinal peristalsis and absorption promotion site The amount of gastrin secretion, a gastrointestinal hormone, is large when stimulating the extension of the first and second fingers and the transitional area of the plantar surface with a perpendicular to the endophysis It was confirmed that it was enhanced. This suggests that digestion and absorption, intestinal peristalsis, etc. are enhanced.
6). Thermal stimulation to the site where the long-lived gene is turned “ON” Adiponectin showed a tendency to increase before and after stimulation between the first and second metatarsal heads. Adiponectin is considered to be one of the substances that activate the sirtuin gene and is one of the genes related to longevity. This suggests that stimulation at two sites in the sole of the foot turned ON the gene related to long life.
7). The amount of secretion decreased in the order of heat stimulation between the 1st and 2nd metatarsal heads, the extension between the 1st and 2nd fingers, and the plantar transition part with a perpendicular line to the incarnate.

  This processing method includes the above-described specific stimulation site (i) the first and second metatarsal head region of the left and right soles, (ii) the second and third intermetacarpal region, (iii) The thermal stimulation is applied to the following specific stimulation site before applying thermal stimulation to at least one of the sites intersecting the perpendicular of the inner eyelid on the extension line of the inner edge between the first and the second. The thermal stimulation is preferably given by an electric thermal stimulation control device or a bag.

This processing method is achieved by applying thermal stimulation to the following specific stimulation site.
(I) Stimulation to the left pond and the center. The abdominal cavity environment is prepared by this stimulation.
(ii) Stimulation of the foot's Sanri and Terumi. In addition to adjusting digestive organs and kidney function, this stimulation also regulates the whole body.
Here, how to give thermal stimulation is as follows.
(I) Set the electric thermal stimulation control device on the left pond / medium and stimulate for 10 minutes. In this case, a gold conductor is attached to the left pond and an aluminum conductor is attached to the center.
(ii) Set Sanri and Terumi of the left and right feet and stimulate for 10 minutes using the electrical thermal stimulation control device. In this case, a gold conductor is attached to the left and an aluminum conductor is attached to the right.

  By performing this processing method described above before applying thermal stimulation to the specific stimulation site described above, the rate of change in blood flow is 200% or more, preferably 300% or more, depending on patient data as shown in FIG. Is obtained.

  Furthermore, in order to exert an effect on the medical condition more, the following processing is performed after applying thermal stimulation to each of the above-described stimulation sites. A visceral body wall reflection point, which is peculiar to a disease state, or a known so-called “acupuncture point” known to be effective for a disease state is given a thermal stimulus. Thus, it was found that it is preferable to be effective for a medical condition.

DESCRIPTION OF SYMBOLS 10 Apparatus main body 12 Conductor 14 Thermal stimulus-like conductor 16 Memory | storage means (memory)
18 Control means (CPU)
20 Output means (output circuit)
22 Temperature sensor

Claims (3)

It is a method of increasing blood flow by applying thermal stimulation to a specific part of the body surface,
Measure the blood flow before giving thermal stimulation to the specific site,
Next, by measuring the blood flow after giving a thermal stimulus to the specific part to determine the rate of increase in blood flow before and after giving the stimulus to the specific part,
The increase in blood flow here is measured using a laser Doppler tissue blood flow meter attached to the center of the wrist joint striation,
A method of increasing blood flow by applying thermal stimulation so that the rate of increase in blood flow before and after the application of stimulus is 30% or more. It is a method of increasing blood flow by applying thermal stimulation to the body surface via a stimulating conductor provided in contact with at least two different specific parts of the body surface,
The thermal stimulation conductor is brought into contact with at least two different specific sites on the body surface so that the rate of increase in blood flow before and after the thermal stimulation is applied is 30% or more. Through the body surface is given a peak temperature; thermal stimulation up to 50 ° C ± 5 ° C,
Here, the increase in blood flow is measured using a laser Doppler tissue blood flow meter attached to the center of the wrist joint striation,
A method of increasing blood flow.   3. The blood flow volume according to claim 1, wherein the specific part is at least two parts including a part intersecting a perpendicular line of the inner eyelid on the extension line of the inner edge between the first and second fingers. How to make.

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