JP2018145148A - Soft capsule agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a soft capsule agent which suppresses delayed breakdown caused by increased viscosity of contents.SOLUTION: A soft capsule agent has: contents made up of anthocyanin, the percentage of which is 5 mass%-25 mass% relative to the total mass of the contents, medium chain fatty acid triglyceride with an average carbon number of constituent fatty acids of 6-12, and lecithin; and a capsule coating.SELECTED DRAWING: None

Description

  The present disclosure relates to soft capsules.

A soft capsule is a capsule film mainly containing gelatin and a plasticizer. For example, a functional component or a functional material is sandwiched and pressure-molded, and is widely used not only in pharmaceuticals but also in the food field. Is one of the dosage forms.
However, it is known that soft capsules have a problem of disintegration delay. In general, when a soft capsule is ingested, the soft capsule disintegrates in the digestive tract, and the components in the capsule film (so-called capsule contents) diffuse out of the capsule film and are digested and absorbed. However, if the soft capsule disintegration delay occurs, the capsule contents cannot be rapidly digested and absorbed in the digestive tract, and the expected effect of the functional component or the like may not be obtained. For this reason, development of soft capsules in which disintegration delay is suppressed has been studied.

For example, Patent Document 1 discloses an oil and mushrooms in which the filling content includes lecithin and citric acid or phytic acid, and further comprises herbal medicines, unsaturated fatty acids, and fats and oils having unsaturated fatty acid residues. Capsules containing one or more selected from the group consisting of are disclosed.
Patent Document 2 discloses that (A) at least one polyphenol selected from the group consisting of anthocyanins, proanthocyanidins, procyanidins and catechins, and (B) soy isoflavones and / or metabolites thereof contain gelatin. A capsule filled in a capsule comprising a capsule film is disclosed.

Japanese Patent No. 4913340 Japanese Patent Laid-Open No. 2006-69335

As a cause of the delay of disintegration of the soft capsule, generally, the interaction between gelatin contained in the capsule film and the capsule contents, or the hardening of the capsule film over time due to cross-linking of gelatin molecules can be considered.
However, as a result of investigations by the present inventors, soft capsules, particularly soft capsules containing a high concentration of functional ingredients or functional materials as capsule contents, have not only cured capsule film over time but also capsule contents. It has been found that a delay in disintegration can also occur by increasing the viscosity of.

  In this regard, the capsules described in Patent Literature 1 and Patent Literature 2 focus only on the hardening of the capsule film as a cause of the capsule disintegration delay, and capsules resulting from the increase in the viscosity of the capsule contents No mention is made of the delay in disintegration of the agent.

  An object of one embodiment of the present invention is to provide a soft capsule in which a delay in disintegration due to an increase in viscosity of a content is suppressed.

Specific means for solving the above problems include the following embodiments.
<1> An anthocyanin having a content of 5% by mass to 25% by mass with respect to the total mass of the content, a medium chain fatty acid triglyceride having an average carbon number of 6 to 12 and fatty acid, and a content containing lecithin, And a capsule capsule.
<2> The soft capsule according to <1>, wherein the content has a viscosity of 20 Pa · s or less at 40 ° C.
<3> The soft capsule according to <1> or <2>, wherein the content further contains a sucrose fatty acid ester.
<4> The soft capsule according to any one of <1> to <3>, wherein the content further contains vitamin C.

  According to one embodiment of the present invention, a soft capsule is provided in which the delay in disintegration due to the high viscosity of the content is suppressed.

  Hereinafter, an example of an embodiment of a soft capsule to which the present invention is applied will be described. However, the present invention is not limited to the following embodiments, and can be implemented with appropriate modifications within the scope of the object of the present invention.

  In the present specification, “disintegration” of a soft capsule means that the capsule film is broken and the contents in the capsule film are diffused into a liquid medium (digested liquid, water, etc.) existing outside the capsule film. .

In the present specification, a numerical range indicated using “to” means a range including the numerical values described before and after “to” as a minimum value and a maximum value, respectively.
In the numerical ranges described stepwise in this specification, the upper limit value or the lower limit value described in one numerical range may be replaced with the upper limit value or the lower limit value of another numerical range. Good. Further, in the numerical ranges described in this specification, the upper limit value or the lower limit value of the numerical range may be replaced with the values shown in the examples.
In the present specification, the amount of each component in the contents, capsule film, or soft capsule is not particularly specified when a plurality of substances corresponding to each component are present in the contents, capsule film, or soft capsule. Unless otherwise indicated, it means the total amount of a plurality of substances present in the contents, capsule film, or soft capsule.

  In this specification, the term “process” is not limited to an independent process, and is included in this term if the intended purpose of the process is achieved even when it cannot be clearly distinguished from other processes. It is.

[Soft capsules]
The soft capsule of the present disclosure includes an anthocyanin having a content of 5% by mass to 25% by mass with respect to the total mass of the content, a medium-chain fatty acid triglyceride having 6 to 12 carbon atoms, and a content containing lecithin. And a capsule film.

The cause of the delay of soft capsule disintegration is generally due to the interaction between gelatin contained in the capsule film and the capsule content (hereinafter simply referred to as “content”), or due to cross-linking of gelatin molecules. The capsule film can be cured.
However, as a result of the study by the present inventors, in soft capsules, particularly soft capsules containing a functional ingredient or functional material in a high concentration as the contents, disintegration delay can occur even when the viscosity of the contents increases. It has been found. When the viscosity of the contents in the capsule film increases, even if the capsule film is broken, the contents are difficult to diffuse into a liquid medium such as digestive fluid or water that exists outside the capsule film, so that the soft capsules are delayed in disintegration. It is speculated that may occur.

  In contrast to the soft capsule disintegration delay resulting from the increase in the viscosity of the content, the soft capsule of the present disclosure includes a medium-chain fatty acid triglyceride having 6 to 12 carbon atoms in the fatty acid as a component contained in the content. By selecting lecithin, an anthocyanin is contained at a content of 5% by mass to 25% by mass with respect to the total mass of the content, but the viscosity of the content is suitable as the content of the soft capsule, After the capsule film is broken, the viscosity is such that the contents in the capsule film can be quickly diffused into the liquid medium (digestion fluid, water, etc.) existing outside the capsule film, and the viscosity is maintained well. Therefore, it is considered that the decay delay is suppressed.

  Note that the above estimation does not limit the effect of the embodiment of the present invention, and is described as an example.

  Hereinafter, the contents of the soft capsule of the present disclosure and each component of the capsule film will be described in detail.

<Contents>
The content in the soft capsule of the present disclosure (hereinafter also simply referred to as “content”) is an anthocyanin having a content of 5% by mass to 25% by mass with respect to the total mass of the content, and the average carbon number of the constituent fatty acids. Medium chain fatty acid triglycerides in which is 6-12, and lecithin.

<< Anthocyanin >>
The content contains anthocyanins at a content of 5% by mass to 25% by mass.
Anthocyanins are pigment components that exist widely in the plant kingdom, and are known to have an antioxidant effect. Anthocyanins are configured as glycosides having anthocyanidins as aglycones, and are classified into three systems, pelargodidin, cyanidin, and delphinidin, depending on the number of B-ring hydroxy groups at the anthocyanidin site that is an aglycone.
Anthocyanins are not particularly limited, and anthocyanins derived from natural products such as plants can be used, as well as synthetic products of anthocyanins obtained according to conventional methods. However, from the viewpoint of quality and productivity, natural products are Anthocyanins derived from plants are preferred, and among the natural products, anthocyanins derived from plants are particularly preferred.

Anthocyanins are contained in plants such as bilberry, blueberry, cranberry, blackberry, raspberry, cassis, acai, hascup, prune, red cabbage, perilla and eggplant, and can be extracted from these plants.
Among these, as anthocyanins, for example, from the viewpoint of containing a lot of good quality anthocyanins, from at least one plant (particularly fruit) selected from the group consisting of bilberry, blueberry, cranberry, blackberry, raspberry, and cassis Extracted anthocyanins are preferred, and anthocyanins extracted from bilberries (ie, anthocyanins derived from bilberries) are particularly preferred.
The extraction method of anthocyanin is not particularly limited, and a known method can be adopted.

The content may contain anthocyanins as an extract containing anthocyanins.
A commercial item can be used as an extract containing anthocyanin.
Examples of commercially available extracts containing anthocyanins include “MyrtArgos (registered trademark)” by Omnica Co., Ltd. (bilberry extract powder, anthocyanin content: 37.0 mass%), “MIRTOSESELECT” by Indena Japan Co., Ltd. (Registered trademark) "(bilberry extract, anthocyanin content: 36% by mass)," BILBERON (registered trademark) "(Bilberry extract, anthocyanin content: 36% by mass), Tokiwa Plant Chemistry Laboratory, BGG JAPAN "MyrtiPro" (Bilberry extract powder, anthocyanin content: 36.0 mass%) etc. are mentioned.

  The contents may contain only one type of anthocyanin or two or more types.

The content of the anthocyanin in the content is 5% by mass to 25% by mass, preferably 10% by mass to 25% by mass, and more preferably 10% by mass to 20% by mass with respect to the total mass of the content. %.
In addition, the “content ratio of anthocyanins in the contents” in the present disclosure means the content ratio of the solid content of anthocyanins in the contents on a mass basis.
When the content of anthocyanin in the content is 5% by mass or more with respect to the total mass of the content, an appropriate amount of ingested grains for obtaining a desired effect expected by ingestion of anthocyanins is appropriate. Can be set within range.
When the content of anthocyanin in the content is 25% by mass or less with respect to the total mass of the content, other components contained in the content and anthocyanin can be mixed well.

<< Medium chain fatty acid triglyceride >>
The content contains medium-chain fatty acid triglyceride (hereinafter, also simply referred to as “medium-chain fatty acid triglyceride”) in which the average carbon number of the constituent fatty acid is 6 to 12.
In the contents, the medium chain fatty acid triglyceride functions as a dispersion medium.
In the soft capsule of the present disclosure, the medium-chain fatty acid triglyceride contributes to the suppression of the decay delay of the soft capsule due to the increase in the viscosity of the contents.
Specifically, in the soft capsule of the present disclosure, the content includes medium-chain fatty acid triglyceride and lecithin described later, thereby containing anthocyanin in an amount of 5% by mass to 25% by mass with respect to the total mass of the content. The content of the capsule is suitable as a soft capsule content, that is, a liquid medium in which the content in the capsule film is present outside the capsule film (digestion fluid, water) Etc.), and the viscosity is well maintained, and it is considered that the delay of disintegration of the soft capsule is suppressed.
Moreover, according to the medium chain fatty acid triglyceride, each component (anthocyanin, lecithin, etc.) contained in the contents can be blended stably.

The average carbon number of the constituent fatty acid in the medium-chain fatty acid triglyceride is the carbon number of the constituent fatty acid [for example, 6 for caproic acid (hexanoic acid), 8 for caprylic acid (octanoic acid), and capric acid (decanoic acid). 10 if present, 12 if lauric acid (dodecanoic acid) is weighted average by the composition ratio of the constituent fatty acids.
The constituent fatty acid may be a saturated fatty acid or an unsaturated fatty acid.
A preferred embodiment of the medium chain fatty acid triglyceride is triglyceride of a saturated fatty acid having 6 to 12 carbon atoms.
The medium chain fatty acid triglyceride may be derived from a natural product or a synthetic fatty acid triglyceride.

As the medium chain fatty acid triglyceride, a commercially available product can be used.
Examples of commercially available products of medium-chain fatty acid triglycerides include “Coconard (registered trademark) RK” (glyceryl tricaprylate), “Coconard (registered trademark) MT” (tri (caprylic acid / capric acid) glyceryl) manufactured by Kao Corporation. , “MT-N” (tri (caprylic acid / capric acid) glyceryl), “conconade (registered trademark) ML” (tri (caprylic acid / capric acid / lauric acid) glyceryl), and the like.
Among these, “Coconard (registered trademark) MT” (tri (caprylic acid / capric acid) glyceryl) is preferably used as a commercial product of medium-chain fatty acid triglycerides.

  The content may contain only one type of medium chain fatty acid triglyceride, or may contain two or more types.

The content of the medium-chain fatty acid triglyceride in the content is, for example, 25% by mass with respect to the total mass of the content from the viewpoint that other components contained in the content and anthocyanin can be mixed better. The above is preferable.
The content of the medium-chain fatty acid triglyceride in the contents is, for example, that the amount of ingested grains for obtaining the desired effect expected by ingestion of anthocyanins can be set within a more appropriate range. From a viewpoint, it is preferable that it is 80 mass% or less with respect to the total mass of the content, It is more preferable that it is 60 mass% or less, It is still more preferable that it is 40 mass% or less.

<< Lecithin >>
The contents include lecithin.
In the soft capsule of the present disclosure, lecithin contributes to suppression of the disintegration delay of the soft capsule due to the increase in the viscosity of the contents.
As described above, in the soft capsule of the present disclosure, the content includes lecithin and the medium-chain fatty acid triglyceride described above, so that the anthocyanin is 5% by mass to 25% by mass with respect to the total mass of the content. The content is suitable for the contents of soft capsules, that is, a liquid medium in which the contents in the capsule film exist outside the capsule film (digestion fluid) after the capsule film is broken , Water, etc.), and the viscosity is maintained at a good level, so that it is considered that the delay of disintegration of the soft capsule is suppressed.

Lecithin chemically means phosphatidylcholine (PC), but is industrially used as the name of a lipid mixture mainly composed of various phospholipids. In the present disclosure, the latter means I am using it.
Representative phospholipids contained in lecithin include phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol, phosphatidic acid, phosphatidylglycerin and the like.
As lecithin, any of lecithin, which is a lipid mixture mainly composed of these phospholipids, can be used.

Lecithin is a kind of glycerophospholipid and is present in all cells of natural animals and plants and is a major component of biological membranes. Accordingly, lecithin can be extracted from any animal or plant, but industrially, lecithin obtained from soybeans or egg yolk as a raw material is common. Hereinafter, soy-derived lecithin is also referred to as “soy lecithin”, and egg yolk-derived lecithin is also referred to as “yolk lecithin”.
Lecithin can be selected from any animal or plant-derived lecithin, including soybean lecithin and egg yolk lecithin, but lecithin derived from plants (for example, soybean, egg yolk and rape) is preferred, mainly from the viewpoint of cost. Lecithin is more preferred.
Soy lecithin is produced by drying and refining oil cake produced as a by-product in the soybean oil refining process. Usually, paste-like lecithin having a phospholipid content of 70% by mass or less is lecithin containing about 30% by mass of crude soybean oil, but since it is inexpensive, pasty lecithin is widely used as lecithin in the food field. .

In recent years, various lecithins with different functions, such as advanced purification, have been added to lecithin due to the physiological activity of phospholipid itself and the need for more advanced emulsifiers. Lecithin, fractionated lecithin, and modified lecithin have been made.
Highly purified lecithin is lecithin obtained by deoiling from pasty lecithin using a solvent such as acetone and pulverizing. In general, lecithin having a lecithin content of 90% by mass or more obtained by purifying pasty lecithin is referred to as highly purified lecithin.
Fractionated lecithin is lecithin obtained by using a difference in solubility in various solvents from highly purified lecithin or increasing the content of a specific phospholipid by an operation such as distillation. Generally, it refers to lecithin with an increased PC content and is commercially available as fractionated lecithin.
Modified lecithin is roughly classified into hydrogenated lecithin and enzymatically decomposed lecithin. Hydrogenated lecithin is a lecithin obtained by converting a fatty acid polyenoic acid in a lecithin structure into a saturated fatty acid by performing a hydrogenation treatment in order to improve oxidation stability and light stability. Enzymatically decomposed lecithin is lecithin obtained by selectively decomposing an ester bond of a fatty acid at the 2-position, which is usually bonded to glycerin, with an enzyme, and may be referred to as type I. Enzymolytic lecithin is referred to as lysolecithin to distinguish it from normal lecithin. Further, as an enzymatically degraded lecithin different from type I, there is lecithin in which an ester bond between phosphoric acid and a base is decomposed, which is sometimes called type II. By performing a decomposition treatment with an enzyme, the base is removed from the phospholipid to form phosphatidic acid (PA).

  In the soft capsule of the present disclosure, any of highly purified lecithin, fractionated lecithin, or modified lecithin can be selected as the lecithin contained in the contents. However, an enzymatically degraded lecithin that is one type of modified lecithin (ie, Although lysolecithin) can improve the dispersibility of each component in the contents, it tends to improve the viscosity of the contents. From the viewpoint of further suppressing the decay delay of the soft capsule, lecithin other than lysolecithin has preferable.

A commercially available product can be used as lecithin.
Examples of commercially available lecithin include J-lecithin CL (trade name, soy lecithin) manufactured by J-Oil Mills, SLP-paste (trade name, soy lecithin paste product) manufactured by Sakai Oil Co., Ltd., and the like. .

  The content may contain only 1 type of lecithin, and may contain 2 or more types.

The content of lecithin in the content is preferably 1% by mass to 10% by mass, more preferably 1% by mass to 8% by mass, and more preferably 1% by mass to 1% by mass with respect to the total mass of the content. More preferably, it is 5 mass%.
When the content of lecithin in the content is 1% by mass or more with respect to the total mass of the content, the effect of suppressing the decay delay of the soft capsule due to the inclusion of lecithin is more effectively exhibited.
When the content of lecithin in the content is 10% by mass or less with respect to the total mass of the content, it is possible to further suppress a decrease in dispersibility of each component in the content, and thus separation of the components. .

The ratio of the content of lecithin to the content of medium-chain fatty acid triglyceride in the content (content of lecithin / content of medium-chain fatty acid triglyceride) is preferably 1% by mass to 15% by mass on a mass basis. It is more preferably 5% by mass to 15% by mass, and further preferably 5% by mass to 10% by mass.
When the ratio of the content of lecithin to the content of medium-chain fatty acid triglyceride in the content is within the above range on a mass basis, the disintegration delay of the soft capsule due to the high viscosity of the content is further suppressed. Can do.

<< sucrose fatty acid ester >>
The content preferably further contains a sucrose fatty acid ester.
In the soft capsule of the present disclosure, the sucrose fatty acid ester contributes to the suppression of the delay of disintegration of the soft capsule due to the increase in the viscosity of the content and the hardening of the capsule film.
Further, when the content further contains a sucrose fatty acid ester, the dispersibility of each component in the content becomes good, and not only the viscosity of the content is suppressed, but also the liquid medium of the components contained in the content Since dispersibility in (digested fluid, water, etc.) can also be improved, an improvement in anthocyanin absorbability in vivo can be expected.

The sucrose fatty acid ester is not particularly limited as long as it can be taken orally.
The number of carbon atoms of the constituent fatty acid in the sucrose fatty acid ester is, for example, preferably 8 or more, more preferably 8-18, and further preferably 10-18, from the viewpoint of exhibiting amphiphilicity. preferable.
The constituent fatty acid may be a saturated fatty acid or an unsaturated fatty acid.

The sucrose fatty acid ester is preferably a sucrose fatty acid ester having an HLB value of 10 or more and a sucrose fatty acid having an HLB value of 12 or more from the viewpoint of improving the dispersibility of the components contained in the content in water. Esters are more preferable, and sucrose fatty acid esters having an HLB value of 14 or more are more preferable.
The upper limit of the HLB value of the sucrose fatty acid ester is preferably 16 or less from the viewpoint of versatility, for example.

In this disclosure, “HLB (Hydrophile-Lipophile Balance) value” means that a commercially available product is used as a component, and the HLB value of the commercially available product is clearly shown in a literature such as a catalog of the commercially available product. The values shown in literatures such as catalogs are adopted.
When the component to be used is not a commercial product, or even if it is commercially available and the HLB value is not clearly shown in the literature such as a catalog, the HLB value in the present disclosure is obtained by the Griffin calculation formula. Adopt value. In the Griffin calculation formula, the HLB value is calculated according to the following formula using the value of S (saponification value of ester) and the value of N (neutralization value of fatty acid constituting the ester). An HLB value closer to 20 means more hydrophilic, and closer to 0 means more lipophilic.
HLB value = 20 (1-S / N)

Specific examples of sucrose fatty acid esters include sucrose laurate, sucrose myristic ester, sucrose palmitate, sucrose stearate, sucrose oleate, and the like.
Among these, as the sucrose fatty acid ester, for example, sucrose stearate is preferable from the viewpoint of miscibility of the contents.

A commercial item can be used as sucrose fatty acid ester.
Examples of commercially available sucrose fatty acid esters include Ryoto (registered trademark) sugar ester S1170 [trade name, sucrose stearate, HLB value: about 11 (catalog value)], Ryoto (manufactured by Mitsubishi Chemical Foods Co., Ltd.) (Registered trademark) sugar ester S1570 [trade name, sucrose stearate, HLB value: about 15 (catalog value)], Ryoto (registered trademark) sugar ester S1670 [trade name, sucrose stearate, HLB value: about 16 (Catalog value)], Ryoto (registered trademark) sugar ester P1570 [trade name, sucrose palmitate, HLB value: about 15 (catalog value)], Ryoto (registered trademark) sugar ester P1670 [trade name, sucrose palmitic acid] Acid ester, HLB value: approx. 16 (catalog value)] Ryoto (trademark) sugar ester L1695 [trade name, sucrose laurate, HLB value: about 16 (catalog value)], and the like.

  When the content further contains a sucrose fatty acid ester, the content may contain only one type of sucrose fatty acid ester, or may contain two or more types.

When the content further contains a sucrose fatty acid ester, the content of the sucrose fatty acid ester in the content is preferably 1% by mass to 10% by mass with respect to the total mass of the content, and is preferably 1% by mass. More preferably, it is -8 mass%, and it is still more preferable that it is 1 mass%-5 mass%.
When the content of the sucrose fatty acid ester in the content is 1% by mass or more with respect to the total mass of the content, the effect of suppressing the decay delay of the soft capsule due to the further inclusion of the sucrose fatty acid ester is more effective. To be played. In addition, since the dispersibility of the components contained in the contents in a liquid medium (digested fluid, water, etc.) can be improved, an improvement in the absorption of anthocyanins in vivo can be expected.
When the content of the sucrose fatty acid ester in the content is 10% by mass or less with respect to the total mass of the content, the viscosity of the content is easily adjusted to an appropriate range.

<< Vitamin C >>
The content preferably further contains vitamin C (so-called L-ascorbic acid).
In the soft capsule of the present disclosure, vitamin C contributes to the suppression of the decay delay of the soft capsule due to the hardening of the capsule film that may be caused by the interaction between the components contained in the contents and the components contained in the capsule film.
For example, when the capsule film contains gelatin, the amino group of gelatin and the hydroxy group of anthocyanin may undergo a condensation reaction to harden the capsule film. Moreover, when the content contains anthocyanin as an extract containing anthocyanin, a carbonyl group or a hydroxy group (particularly a carbonyl group) contained in the anthocyanin-containing extract and an amino group contained in gelatin Condensation reaction may cause the capsule film to harden.
According to vitamin C, hardening of the capsule film due to the condensation reaction between the components contained in the contents and the components contained in the capsule film can be suppressed.

When the content further contains vitamin C, the content of vitamin C in the content is preferably 1% by mass to 20% by mass with respect to the total mass of the content, and 1% by mass to 15% by mass. It is more preferable that it is 1 mass%-10 mass%.
When the content of vitamin C in the content is 1% by mass or more with respect to the total mass of the content, the effect of suppressing the decay delay of the soft capsule due to further containing vitamin C is more effectively exhibited. .
When the content of vitamin C in the content is 20% by mass or less with respect to the total mass of the content, the components contained in the content can be kept more stable.

<< other ingredients >>
The contents include anthocyanins, which are essential components, medium chain fatty acid triglycerides, and lecithin, and other components other than sucrose fatty acid esters and vitamin C, which are optional components, within a range that does not impair the effect of one embodiment of the present invention. It may be included as necessary.
Examples of other components include components that are generally accepted for use in foods.
Examples of such components include emulsifiers (excluding the aforementioned lecithin and sucrose fatty acid ester), antifoaming agents, antioxidants, stabilizers, sweeteners, acidulants, preservatives, colorants, and fragrances. It is done.
In addition, examples of other components include functional components that are expected to bring about beneficial health effects (effects such as health maintenance, health promotion, prevention or improvement of lifestyle-related diseases) by ingestion.
Such functional ingredients include various vitamins (excluding the aforementioned vitamin C), minerals, crocetin, collagen (hydrolyzed collagen, water-soluble collagen, etc.), ornithine, resveratrol, chlorogenic acid, caffeic acid, ubiquinone. (Coenzyme Q10, etc.), flavonoids (flavanone, flavone, flavonol, isoflavone, catechin, etc.), carotenoids (astaxanthin, lutein, etc.), lignans (sesamin, sesamorin, etc.), curcumin and the like. The functional component may be a plant-derived component, an animal-derived component, a fermentation product of yeast, or a chemically synthesized product suitable for edible use.

~emulsifier~
The contents may further contain an emulsifier other than the above-described lecithin and the above-described sucrose fatty acid ester (hereinafter also referred to as “other emulsifier”).
By containing the other emulsifier, the content can more stably contain a dispersoid such as sucrose fatty acid ester in the dispersion medium containing the medium chain fatty acid triglyceride.

There is no restriction | limiting in particular as another emulsifier, For example, a nonionic surfactant (except the above-mentioned sucrose fatty acid ester) is preferable.
Examples of nonionic surfactants include glycerin fatty acid esters and polyglycerin condensed ricinoleic acid esters.
The nonionic surfactant is preferably a glycerin fatty acid ester having an HLB value of 1 to 15, more preferably a glycerin fatty acid ester having an HLB value of 1 to 10, and an HLB value of 2 from the viewpoint of the miscibility of the contents. More preferred are glycerin fatty acid esters of ˜8.
Examples of glycerin fatty acid esters include polyglycerin having an average degree of polymerization of 1 to 10, and fatty acids having 8 to 18 carbon atoms, such as caprylic acid (octanoic acid), capric acid (decanoic acid), lauric acid (dodecanoic acid), and myristic. With acid (tetradecanoic acid), palmitic acid (hexadecanoic acid), stearic acid (octadecanoic acid), oleic acid (cis-9-octadecenoic acid), or linoleic acid (cis, cis-9,12-octadecadienoic acid) An ester is preferred.

A commercially available product can be used as the glycerin fatty acid ester.
Examples of commercially available products of glycerin fatty acid ester include EXOEL (registered trademark) S-95 (trade name, glyceryl monostearate, HLB value: 3.8 (catalog value)) of Kao Corporation, RIKEN VITAMIN CO., LTD. Emax (registered trademark) BW-36 [trade name, HLB value: 3 to 5 (catalog value)], SY Glyster (registered trademark) MS-3S of Sakamoto Pharmaceutical Co., Ltd. (trade name, tetraglycerin monostearic acid) Ester, HLB value: 8.4 (catalog value)], SY Glyster (registered trademark) MO-3S [trade name, tetraglycerin monooleate, HLB value: 8.8 (catalog value)], SY glister (registered) Trademark) PO-5S [trade name, hexaglycerin pentaoleate, HLB value: 4.7 (catalog value)] and the like.

  When the content contains other emulsifiers, the content may contain only 1 type of other emulsifiers, and may contain 2 or more types.

  When the content contains another emulsifier, the content of the other emulsifier in the content is preferably 1 part by weight to 1000 parts by weight, for example, with respect to 100 parts by weight of the medium chain fatty acid triglyceride described above. More preferably, they are 1 mass part-100 mass parts, More preferably, they are 1 mass part-50 mass parts, Especially preferably, they are 1 mass part-10 mass parts.

In particular, when the content contains glycerin fatty acid ester as another emulsifier, the content of glycerin fatty acid ester in the content is preferably 1% by mass to 10% by mass with respect to the total mass of the content, The content is more preferably 1% by mass to 8% by mass, and further preferably 1% by mass to 5% by mass.
When the content of the glycerin fatty acid ester in the content is 1% by mass or more with respect to the total mass of the content, the effect of suppressing the decay delay of the soft capsule due to the further inclusion of the glycerin fatty acid ester is more effectively achieved. Is done. In addition, since the dispersibility of the components contained in the contents in a liquid medium (digested fluid, water, etc.) can be improved, an improvement in the absorption of anthocyanins in vivo can be expected.
When the content of the glycerin fatty acid ester in the content is 10% by mass or less with respect to the total mass of the content, the viscosity of the content is easily adjusted to an appropriate range.

<Physical properties of contents>
The viscosity of the content at 40 ° C. is preferably 20 Pa · s or less.
When the viscosity of the content at 40 ° C. is 20 Pa · s or less, the disintegration delay of the soft capsule due to the high viscosity of the content is further suppressed. Moreover, it is more excellent in operability when the capsule film is filled with the contents.
Further, the viscosity of the content at 40 ° C. is preferably 5 Pa · s or more, and more preferably 10 Pa · s or more.
When the viscosity of the content at 40 ° C. is 5 Pa · s or more, a decrease in dispersibility of each component in the content, and thus separation of the components can be further suppressed.
The viscosity of the contents at 40 ° C. is a value measured using a B-type viscometer.
The viscosity of the content at 40 ° C is, for example, a B-type viscometer (product name: VISCOMETER TV-22, rotor: No. 4) manufactured by Toki Sangyo Co., Ltd. )).

<Capsule film>
The capsule film in the soft capsule of the present disclosure is not particularly limited as long as it contains a component that is generally used as a raw material for a soft capsule film.
Examples of the capsule film component include gelatin, carrageenan, polyhydric alcohol, and water. A preferred embodiment of the capsule film is an embodiment containing gelatin and a polyhydric alcohol.

<< Gelatin >>
Any gelatin can be used without particular limitation as long as it is generally used in a soft capsule film.
The gelatin content in the capsule film is not particularly limited, and is preferably 60% by mass to 90% by mass with respect to the total mass of the capsule film, for example.
A commercially available product can be used as the gelatin.
Examples of commercially available gelatin products include gelatin GSCSKN2 (trade name, gelatin derived from cattle) from Nitta Gelatin Co., Ltd.

<< polyhydric alcohol >>
As the polyhydric alcohol, any polyhydric alcohol generally used for a soft capsule film can be used without particular limitation.
Specific examples of the polyhydric alcohol include glycerin, sorbitol, mannitol, maltitol and the like.
Among these, as the polyhydric alcohol, glycerin is preferable from the viewpoint of imparting stability as a capsule.
The content rate of the polyhydric alcohol in the capsule film is not particularly limited, and is preferably 10 parts by mass to 70 parts by mass with respect to 100 parts by mass of gelatin, for example.
When the content of the polyhydric alcohol in the capsule film is 10 parts by mass or more with respect to 100 parts by mass of gelatin, the formability of the capsule film is improved.
When the content of the polyhydric alcohol in the capsule film is 70 parts by mass or less with respect to 100 parts by mass of gelatin, the capsule strength can be maintained and deformation of the capsule can be suppressed.

<< water >>
The capsule film may contain water.
The water is not particularly limited as long as it is a drinkable water that has been subjected to appropriate foreign matter treatment for ordinary foods.
When the capsule film contains water, the content of water in the capsule film can be, for example, 5% by mass to 10% by mass with respect to the total mass of the capsule film.
The water content in the capsule film is a value measured by the Karl Fischer method.

<< other ingredients >>
The capsule film may contain other components as necessary within the range not impairing the effect of the embodiment of the present invention.
Examples of other components include pigments and anti-adhesive agents (modified starch, silicon dioxide, etc.).

[Method for producing soft capsules]
There is no restriction | limiting in particular as a manufacturing method of the soft capsule of this indication, A well-known method is employable.
An example of a preferable method for producing the soft capsule of the present disclosure will be described in detail.
The soft capsule of the present disclosure includes a composition (that is, a content) containing 5 mass% to 25 mass% of anthocyanin, a medium-chain fatty acid triglyceride, and lecithin, and a step of preparing a capsule coating composition (A And a step (B) of encapsulating the contents in the capsule film composition to obtain a soft capsule precursor and a step (C) of drying the obtained soft capsule precursor. be able to.
The soft capsule precursor obtained in the step (B) is a production intermediate that can form the soft capsule of the present disclosure, and is dried in the step (C) to obtain the soft capsule of the present disclosure that is the final product. It is done.

<Process (A)>
In the step (A), a composition (that is, the content) containing 5% by mass to 25% by mass of anthocyanin, a medium chain fatty acid triglyceride, and lecithin, and a capsule film composition are prepared.

(Preparation of contents)
Regarding the types of the essential components and optional components contained in the contents, suitable aspects, etc., the matters relating to the contents of the soft capsule described above are similarly applied.
The contents can be prepared by mixing essential and optional components contained in the contents. For example, the method of mixing the essential components anthocyanin, medium chain fatty acid triglyceride, and lecithin is not particularly limited. For example, all the components may be mixed at once, or medium chain fatty acid triglyceride and lecithin are mixed. After mixing, the obtained mixed solution and anthocyanin may be mixed.
From the viewpoint of stably blending the anthocyanins, it is preferable to mix the medium-chain fatty acid triglyceride and lecithin, then cool the obtained mixed liquid, and mix the cooled mixed liquid and the anthocyanins.
The cooling temperature of the mixed solution is not particularly limited, but is preferably 40 ° C. or lower from the viewpoint of suppressing decomposition of anthocyanin by heating.

There is no restriction | limiting in particular as a mixing means, A general mixing instrument or mixing apparatus can be used. Examples of the mixing device or mixing device include a stirrer and a mixer.
Conditions such as temperature and time during mixing are not particularly limited, and can be appropriately adjusted depending on the types of components contained in the contents.

The prepared contents may be pulverized before the next step (B).
The pulverizing means is not particularly limited, and examples thereof include an apparatus suitable for dry pulverization of food raw materials, specifically, means using an apparatus such as a fine pulverizer, a grinder, a crusher, and a mill.

(Preparation of composition for capsule film)
As for the types of components contained in the capsule film composition, preferred embodiments, etc., the matters relating to the capsule film of the soft capsule described above are similarly applied.
The capsule film composition can be prepared by mixing the components contained in the capsule film composition.

There is no restriction | limiting in particular as a mixing means, A general mixing instrument or mixing apparatus can be used. Examples of the mixing device or mixing device include a stirrer and a mixer.
Conditions such as temperature and time during mixing are not particularly limited, and can be appropriately adjusted depending on the types of components contained in the contents.

For example, when the capsule film composition contains gelatin, the content of gelatin in the capsule film composition is preferably 60% by mass to 90% by mass with respect to the total mass of the capsule film composition. 60 mass% to 70 mass% is more preferable.
For example, when the capsule coating composition contains a polyhydric alcohol, the content of the polyhydric alcohol in the capsule coating composition is 10% by mass to 40% by mass with respect to the total mass of the capsule coating composition. It is preferable that it is 20 mass%-40 mass%.

<Process (B)>
In the step (B), the contents are encapsulated in the capsule film composition to obtain a soft capsule precursor.
The soft capsule precursor encapsulates a composition (that is, a content) containing 5% by mass to 25% by mass of anthocyanin, medium chain fatty acid triglyceride, and lecithin in a capsule film composition having a film-like form. Can be obtained.
The “capsule film composition” as used in the present disclosure includes both forms formed into a film form and forms not formed into a specific shape.

  There is no restriction | limiting in particular as a method of enclosing the content in the composition for capsule films, The method of using well-known manufacturing apparatuses, such as a rotary type (for example, rotary die type), a seamless type, a flat plate type, is mentioned. As a method using a rotary die type automatic soft capsule manufacturing machine which is an example of a rotary type, for example, the method described in paragraphs [0024] to [0031] of JP-A No. 2004-351007 is also used in this step. Can be applied.

  For example, as a method for encapsulating the contents in the capsule film composition, a laminate is formed by sandwiching the contents between two sheets of the capsule film composition formed into a sheet shape, and forming the laminate A flat plate method in which the body is compressed from both sides with a mold and punched out can be adopted as necessary.

<Process (C)>
In the step (C), the obtained soft capsule precursor is dried.
By passing through this process, a finished soft capsule is obtained.

There is no restriction | limiting in particular as a method of drying a soft capsule precursor, A well-known drying apparatus can be used. Examples of the drying device include a tumbler dryer (that is, a rotary drum dryer). Conditions such as temperature and time during drying are not particularly limited, and can be appropriately adjusted depending on the components contained in the contents and the types of components contained in the capsule film.
After drying with a dryer, it is preferable to further dry the soft capsule precursor.
In this case, the drying temperature is preferably about 20 ° C. to 30 ° C., the humidity is preferably about 10% RH to 50% RH, and the drying time is preferably about 3 to 10 days.

<Shape of soft capsule>
There is no restriction | limiting in particular as a shape of the soft capsule of this indication.
The soft capsule of the present disclosure may adopt any shape such as an oval (OVAL), a rectangle (OBLONG), and a sphere (ROUND). Any of the methods or devices well known in the art can be applied to achieve these shapes.

  EXAMPLES Hereinafter, the present invention will be described more specifically with reference to examples. However, the present invention is not limited to the following examples unless it exceeds the gist thereof.

[Manufacture of soft capsules]
Soft capsules of Examples 1 to 3 and Comparative Examples 1 to 3 were produced as follows. The amount of each component used for the preparation of the contents is as shown in Table 1. Table 2 shows the composition per one of the soft capsules of Examples 1 to 3.

<Example 1>
Medium chain fatty acid triglyceride [trade name: Coconut (registered trademark) MT, tri (caprylic acid / capric acid) glycerin, Kao Corporation] and glycerin fatty acid ester [trade name: EXCEL (registered trademark) S-95, lipophilic Type glyceryl monostearate, HLB value: 3.8 (catalog value), Kao Co., Ltd.] under heating at 70 ° C. or higher, and a uniform mixture (hereinafter referred to as “first mixture”) It was obtained. In addition, it confirmed visually that the 1st mixture was uniform.

  Next, after cooling the temperature of the first mixture to 40 ° C. or lower, the lecithin [trade name, soybean lecithin, lecithin content: 100% by mass, J-Oil Co., Ltd.] with respect to the first mixture after cooling. Mills] was added and mixed well to obtain a second mixture. Marigold dye lumber [trade name: Lutein Hi-Fil (registered trademark) 20, Omnica Co., Ltd.] was added to the obtained second mixture and mixed well to obtain a third mixture. .

Next, bilberry extract powder [anthocyanidin (aglycone conversion)> 25 mass%, anthocyanin (glycoside)> 37 mass%] was added to the obtained third mixture, and mixed well, A mixture was obtained.
Note that a stirrer was used for the above mixing.

Next, the obtained fourth mixture was pulverized using a wet mill to obtain a pulverized product. It was confirmed that 90% or more of the obtained pulverized product passed through a filter having an aperture of 210 μm (about 70 mesh).
Next, the entire amount of the obtained pulverized product was sufficiently mixed using a stirrer under reduced pressure at room temperature (25 ° C.), and the resulting mixture was used as the contents of the soft capsule.

  Gelatin sheet containing 45 parts by weight of glycerin [trade name: SUPEROL (registered trademark) K, P & G Co.] with respect to 100 parts by weight of gelatin [trade name: gelatin GSCSKN2, bovine-derived gelatin, Nitta Gelatin Co., Ltd.] While being fed to the die roll, 350 mg of the contents of the soft capsule were dropped onto the sheet joint portion to prepare an oval-shaped soft capsule precursor.

The produced soft capsule precursor was subjected to tumbler drying and stationary drying to obtain a soft capsule. When the weight of the soft capsule was measured, it was 530 ± 30 mg per grain.
In the obtained soft capsule, defects such as scratches and cracks were not observed.

<Example 2>
In Example 1, after obtaining the third mixture, instead of adding only the bilberry extract powder to the obtained third mixture, bilberry extract powder and sucrose fatty acid ester [trade name: Ryoto (registered trademark) ) Sugar ester S1570] was added and mixed well to obtain a soft capsule by performing the same operation as in Example 1, except that a fourth mixture was obtained. When the weight of the soft capsule was measured, it was 530 ± 30 mg per grain.
In the obtained soft capsule, defects such as scratches and cracks were not observed.

<Example 3>
In Example 1, after obtaining the third mixture, instead of adding only bilberry extract powder to the obtained third mixture, bilberry extract powder and vitamin C [trade name, vitamin C powder, (stock) ) Maechu] was added and mixed well to obtain a fourth mixture, and a soft capsule was obtained in the same manner as in Example 1. When the weight of the soft capsule was measured, it was 530 ± 30 mg per grain.
In the obtained soft capsule, defects such as scratches and cracks were not observed.

<Comparative Example 1>
Olive oil [trade name: Refined, DSP Gokyo Food & Chemical Co., Ltd.], beeswax [trade name: food additive bees wax, Miki Chemical Industry Co., Ltd.], and glycerin fatty acid ester [trade name: Excel (registered) (Trademark) S-95] was sufficiently mixed under heating at 70 ° C. or higher to obtain a uniform mixture (hereinafter referred to as “first mixture”). In addition, it confirmed visually that the 1st mixture was uniform.

  Next, the temperature of the first mixture was cooled to 40 ° C. or lower. After sufficiently cooling, Marigold dye lumber [trade name: Lutein Hi-Fil (registered trademark) 20] was added to the cooled first mixture and mixed well to obtain a second mixture. .

Next, bilberry extract powder was added to the obtained second mixture and mixed well to obtain a third mixture.
Note that a stirrer was used for the above mixing.

Next, the obtained third mixture was pulverized using a wet mill to obtain a pulverized product. It was confirmed that 90% or more of the obtained pulverized product passed through a filter having an aperture of 210 μm (about 70 mesh).
Next, the entire amount of the obtained pulverized product was sufficiently mixed using a stirrer under reduced pressure at room temperature (25 ° C.), and the resulting mixture was used as the contents of the soft capsule.

  The gelatin capsule containing 45 parts by mass of glycerin [trade name: SUPEROL (registered trademark) K] with respect to 100 parts by mass of gelatin [trade name: gelatin GSCSKN2] is fed to the die roll while the contents of the soft capsules 350 mg was dropped to produce an elliptical (OVAL) soft capsule precursor.

The produced soft capsule precursor was subjected to tumbler drying and stationary drying to obtain a soft capsule. When the weight of the soft capsule was measured, it was 530 ± 30 mg per grain.
In the obtained soft capsule, defects such as scratches and cracks were not observed.

<Comparative Example 2>
Olive oil [trade name: refined], beeswax [trade name: food additive bees wax], and glycerin fatty acid ester [trade name: EXCEL (registered trademark) S-95] under heating at 70 ° C. or higher, Thorough mixing was performed to obtain a uniform mixture (hereinafter referred to as “first mixture”). In addition, it confirmed visually that the 1st mixture was uniform.

  Next, the temperature of the first mixture was cooled to 40 ° C. or lower. After sufficiently cooling, Marigold dye lumber [trade name: Lutein Hi-Fil (registered trademark) 20] was added to the cooled first mixture and mixed well to obtain a second mixture. .

Next, bilberry extract powder and vitamin C [trade name, vitamin C powder] were added to the obtained second mixture and mixed thoroughly to obtain a third mixture.
Note that a stirrer was used for the above mixing.

Next, the obtained third mixture was pulverized using a wet mill to obtain a pulverized product. It was confirmed that 90% or more of the obtained pulverized product passed through a filter having an aperture of 210 μm (about 70 mesh).
Next, the entire amount of the obtained pulverized product was sufficiently mixed using a stirrer under reduced pressure at room temperature (25 ° C.), and the resulting mixture was used as the contents of the soft capsule.

  The gelatin capsule containing 45 parts by mass of glycerin [trade name: SUPEROL (registered trademark) K] with respect to 100 parts by mass of gelatin [trade name: gelatin GSCSKN2] is fed to the die roll while the contents of the soft capsules 350 mg was dropped to produce an elliptical (OVAL) soft capsule precursor.

The produced soft capsule precursor was subjected to tumbler drying and stationary drying to obtain a soft capsule. When the weight of the soft capsule was measured, it was 530 ± 30 mg per grain.
In the obtained soft capsule, defects such as scratches and cracks were not observed.

<Comparative Example 3>
Safflower oil [trade name, edible oil and fat, Nissin Oilio Co., Ltd.] and beeswax [trade name: food additive bees wax] are thoroughly mixed under heating at 70 ° C. or more to obtain a uniform mixture ( Hereinafter, the “first mixture” was obtained. In addition, it confirmed visually that the 1st mixture was uniform.

  Next, the temperature of the first mixture was cooled to 40 ° C. or lower, and lysolecithin [trade name, SLP-paste lyso, Tsuji Oil Co., Ltd.] was added to the cooled first mixture. The mixture (hereinafter referred to as “second mixture”) was cooled to 40 ° C. or lower.

Next, bilberry extract powder was added to the cooled second mixture and mixed well to obtain a third mixture.
Note that a stirrer was used for the above mixing.

Next, the obtained third mixture was pulverized using a wet mill to obtain a pulverized product. It was confirmed that 90% or more of the obtained pulverized product passed through a filter having an aperture of 210 μm (about 70 mesh).
Next, the entire amount of the obtained pulverized product was sufficiently mixed using a stirrer under reduced pressure at room temperature (25 ° C.), and the resulting mixture was used as the contents of the soft capsule.

  The gelatin capsule containing 45 parts by mass of glycerin [trade name: SUPEROL (registered trademark) K] with respect to 100 parts by mass of gelatin [trade name: gelatin GSCSKN2] is fed to the die roll while the contents of the soft capsules 350 mg was dropped to produce an elliptical (OVAL) soft capsule precursor.

The produced soft capsule precursor was subjected to tumbler drying and stationary drying to obtain a soft capsule. When the weight of the soft capsule was measured, it was 530 ± 30 mg per grain.
In the obtained soft capsule, defects such as scratches and cracks were not observed.

[Evaluation]
1. Measurement of Viscosity of Contents The viscosity (unit: Pa · s) of the contents used for the production of each soft capsule of Examples 1 to 3 and Comparative Examples 1 to 3 was measured.
Viscosity was measured using a B-type viscometer [product name: VISCOMETER TV-22, rotor: No. 4, Toki Sangyo Co., Ltd.] and the number of revolutions was 6 rpm.
The results are shown in Table 1.

2. Soft Capsule Disintegration Test The soft capsules of Examples 1 to 3 and Comparative Examples 1 to 3 were stored in an environment with an ambient temperature of 40 ° C. and a relative humidity of 75%. For the soft capsules of Examples 1 to 3, the disintegration test was conducted after 1 month and 2 months from storage, and for the soft capsules of Comparative Examples 1 to 3 after 1 month from storage. went.
The disintegration test was conducted in accordance with “6.09 Disintegration Test Method” described in the General Test Method of the 17th revised Japanese Pharmacopoeia. In addition, ion-exchange water was used as a test solution. Further, as a disintegration tester, a disintegration tester D (product name) manufactured by Miyamoto Riken Kogyo Co., Ltd. was used.
The time at which the soft capsule was found to be disintegrated was taken as the disintegration time, and the disintegration property of the soft capsule was evaluated according to the following evaluation criteria based on the disintegration time of the soft capsule after one month from storage.
In this disintegration test, a long disintegration time indicates that the disintegration delay of the soft capsule is caused by the increase in the viscosity of the contents or the increase in the viscosity of the contents and the hardening of the capsule film.
In this disintegration test, in view of merchantability, if the evaluation result of the soft capsules after one month from storage was “A” or “B”, it was determined that there was no problem.
The results are shown in Table 1.

-Evaluation criteria-
A: Disintegration time is less than 20 minutes.
B: Disintegration time is 20 minutes or more and less than 30 minutes.
C: Disintegration time is 30 minutes or more and less than 90 minutes.
D: Disintegration time is 90 minutes or more.

  The numerical value described in the column of each component in Table 1 indicates the blending amount (unit: mass%) of the component, and “-” indicates that the component is not blended.

  The numerical value described in the column of each component in Table 2 indicates the amount (unit: mg) of each component contained per soft capsule, and “-” indicates that the component is not included.

As shown in Table 1, the contents of the soft capsules of Examples 1 to 3 containing 5% by mass to 25% by mass of anthocyanin, medium chain fatty acid triglyceride, and lecithin include medium chain fatty acid triglyceride and lecithin. The viscosity was low compared with the contents of the soft capsules of Comparative Examples 1 to 3.
Moreover, compared with the soft capsules of Comparative Examples 1 to 3, the soft capsules of Example 1 to Example 3 suppressed the decay delay of the soft capsules.

According to the contrast between the soft capsule of Example 1 and the soft capsule of Example 2, in addition to 5% by mass to 25% by mass of anthocyanin, medium-chain fatty acid triglyceride, and lecithin, further containing sucrose fatty acid ester It can be seen that the decay delay of the soft capsule is further suppressed.
In addition, according to the comparison between the soft capsule of Example 1 and the soft capsule of Example 3, in addition to 5 mass% to 25 mass% of anthocyanin, medium chain fatty acid triglyceride, and lecithin, further containing vitamin C It can be seen that the decay delay of the soft capsule is remarkably suppressed. Furthermore, according to the contrast between the soft capsule of Example 2 and the soft capsule of Example 3, it can be seen that vitamin C is superior to the sucrose fatty acid ester in the decay delaying effect of the soft capsule.

Claims (4)

  An anthocyanin having a content of 5% by mass to 25% by mass with respect to the total mass of the content, a medium-chain fatty acid triglyceride having an average carbon number of 6 to 12 of the constituent fatty acid, and a lecithin content, and a capsule film A soft capsule.   The soft capsule according to claim 1, wherein the viscosity of the content at 40 ° C is 20 Pa · s or less.   The soft capsule according to claim 1 or 2, wherein the content further comprises a sucrose fatty acid ester.   The soft capsule according to any one of claims 1 to 3, wherein the content further contains vitamin C.