JP2018092515A - Genetic information analysis system and genetic information analysis method - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a genetic information analysis system capable of providing in a state easy to use for genetic information users, by acquiring gene information including image data from a gene information provider.SOLUTION: An genetic information analysis system 1 according to the present invention, acquires gene information including image data and clinical information corresponding to the gene information from the gene information provider 2 via an internet line 3, classifies, organizes and accumulates the genetic information as combined data associated with the medical information, and provides the combined data via an internet line 4 in response to a request from the genetic information user 5.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a system and method for collecting genetic information from outside such as a medical researcher, analyzing, organizing, and classifying the information, and providing the information to the user.

  Conventionally, genetic analysis information and disease information such as disease name and patient characteristics are owned by individual medical researchers and are often published in papers and are often kept secret. It was hard to say that it was available. On the other hand, the re-published patent WO2002 / 044967 discloses a gene analysis information providing method and system, and an authentication identification method, which are systems for obtaining gene information, creating a database, and providing it to a customer.

  In addition, JP 2014-78202 makes it possible to predict a specific tendency from genetic information by constructing and publishing a database in which genetic information is associated with a specific tendency of a person. An invention that enables people to take appropriate actions based on the trends predicted from genetic information by building and publishing a database on behavioral results and changes in those people It is disclosed.

  Furthermore, Japanese Patent Application Laid-Open No. 2005-063272 describes a gene expression information display device that facilitates gene expression evaluation. Japanese Patent Application Laid-Open No. 2003-242154 describes a device that comprehensively manages image information and gene information acquired by various gene expression experiments and extracts knowledge without omission.

  Furthermore, in JP 2010-218150, a large amount of expression profile data is analyzed at high speed with a normal computer, the expression pattern of the gene is visualized, and it is easy to determine which gene has a function close to which gene. Describes the expression profile analysis system to be analyzed.

Republished patent WO2002 / 044967 Japanese Unexamined Patent Publication No. 2014-78202 JP 2005-063272 JP JP 2003-242154 A JP 2010-218150 A

  However, these systems and methods only store patient genetic analysis information as document data and provide it to the outside as required, collect imaged data from genetic information providers, It was not possible to organize and save patients and IT companies with large-scale analysis systems so that they could be easily used. In other words, the conventional technology only analyzes data based on document data or numerical data, and only stores and displays it as an image. Therefore, it is convenient for users who use the stored data by extracting it from the system. There was a problem with sex. Moreover, it merely provided an individual system for visualizing genetic information and organizing the visualized information.

  The gene information analysis system according to the present invention obtains genetic information including image data and medical information corresponding to the genetic information from outside, and classifies, organizes, and stores the genetic information as combined data associated with the medical information. Then, the combined data is provided in response to an external request.

  The gene information including the image includes character information including numerical values and gene information including image information such as a heat map and a cluster diagram.

  The gene information analysis system classifies the binding data in a predetermined format by analyzing either or both of image information and character information included in the binding data.

  In addition, gene information and clinical information corresponding to the gene information are accumulated in the analysis system in a state of combined data in a one-to-one combination.

  The binding data is classified and accumulated based on the image data of the gene information.

  Further, the gene information analysis system is provided with either or both of an image analysis function based on artificial intelligence and a natural language processing function, and classification of image data is performed based on artificial intelligence.

  The gene information analysis system has a microarray analysis program.

  Furthermore, the gene information analysis method according to the present invention includes a step of acquiring genetic information including image data and medical information corresponding to the genetic information from outside, and classifying the genetic information as combined data associated with the medical information. , Organizing and storing, and providing the combined data in response to an external request.

  The gene information analysis method includes providing a gene information provider with a microarray analysis program stored in a gene information analysis system, providing gene information including image data and medical information corresponding to the gene information to the gene information A step of acquiring from a person, a step of classifying, organizing and storing the genetic information as binding data associated with the medical information, and a step of providing the binding data in response to a request from a genetic information user It is a thing.

  Furthermore, the provision of the microarray analysis program to the gene information provider is performed on the condition that the gene information provider provides the gene information and medical data to the administrator of the gene information analysis system.

  The gene information analysis system according to the present invention can analyze combined data composed of genetic information including image data and medical information, and classify and store them by classifying disease names and patient characteristics as keys. Further, when analyzing the combined data, the analysis system categorizes and stores the combined data in a format that can be easily used by the user by analyzing either or both of image information and character information included in the combined data. be able to. Therefore, a user who accesses the gene information analysis system can acquire binding data including image information in a desired group such as a disease name and a patient attribute, and can use it for drug development and disease diagnosis / treatment.

  In addition, since one or both of the image processing function using artificial intelligence and the natural language processing function are utilized for classification and organization of genetic information, appropriate classification and organization can be performed quickly.

  Furthermore, the provision of the microarray analysis program to the gene information provider is performed on condition that the gene information provider provides the gene information and medical data to the administrator of the gene information analysis system. It can be collected effectively.

1 is an overall configuration diagram illustrating a usage state of a gene information analysis system according to Embodiment 1. FIG. 1 is a block diagram illustrating a configuration of a gene information analysis system according to Embodiment 1. FIG. FIG. 3 is a flowchart showing the operation of the gene information analysis system of the first embodiment. It is the whole block diagram which shows the other utilization condition of the gene information analysis system of Embodiment 2. It is a reference figure which shows an example of the numerical analysis data of gene information. It is a reference figure which shows an example which added the image data by carrying out the array analysis of the numerical analysis data of gene information. It is a reference figure which shows an example of the image data obtained by carrying out array analysis of the numerical analysis data of gene information. It is a reference figure which shows an example of the cluster figure obtained by carrying out the array analysis of the numerical analysis data of gene information.

Embodiment 1 FIG.
FIG. 1 is an overall configuration diagram showing a utilization state of the gene information analysis system according to the first exemplary embodiment of the present invention. In FIG. 1, reference numeral 1 denotes a gene information analysis system (hereinafter simply referred to as an analysis system) that analyzes and accumulates gene information. Reference numeral 2 denotes a genetic information provider such as a medical institution or a researcher. Reference numeral 3 denotes an Internet line that collects genetic information from the genetic information provider 2 and transmits it to the analysis system 1. Reference numeral 4 denotes an Internet line for transmitting gene information sorted and classified by the analysis system 1 to the gene information user 5 as a user.

  FIG. 2 is an internal block diagram showing functions of the analysis system 1 in FIG. FIG. 3 is a flowchart showing the operation steps of the gene information analysis system of the present invention in FIGS. 1 and 2.

  Next, the operation of the genetic information analysis system according to the present invention will be described with reference to FIG. 1, FIG. 2, and FIG. Gene information held by a medical researcher who is a gene information provider is usually displayed as numerical data as shown in FIG. However, since such numerical data is an enumeration of numbers, letters and symbols, it is extremely inconvenient for medical researchers in this state.

  Therefore, it is necessary to analyze such numerical data, convert gene information into image data, and visualize it. As an example of imaging genetic information, Fig. 6 shows how numerical data can be analyzed using "Simple Array Analyzer", an array (gene expression) analysis software developed by iAnalyze, a venture company from Kagoshima University. A part of the image is converted into a heat map and embedded in the table. In FIG. 6, cases (tumor group control group) corresponding to the heat map of the gene data are also entered.

  In FIG. 1, the analysis system 1 acquires gene information that is converted into image data as shown in FIG. 6 and includes correspondence with a case from the gene information provider 2 via the Internet line 3.

  In addition, the administrator of the analysis system 1 pays a gene information array analysis software to the gene information provider 2 free of charge or at a low price as a compensation for the gene including the imaged data after analysis from the gene information provider 2. Information may be acquired. In FIG. 1, the genetic information is sent to the analysis system 1 via the Internet line 3, but may be sent by other media such as a CD-ROM.

  Further, the analysis system 1 may acquire genetic information including a cluster diagram as shown in FIG. 7 instead of or in addition to the heat map diagram in the table of FIG. Moreover, you may acquire the gene information containing both a heat map figure and a cluster figure.

  Next, the block configuration inside the analysis system 1 will be described with reference to FIG. In FIG. 3, reference numeral 11 denotes a first data storage unit that temporarily stores gene information provided from the gene information provider 2. The data stored in the first storage unit 11 is combined information obtained by combining clinical information corresponding to gene information including image data. Reference numeral 12 denotes a data processing unit for analyzing gene information which is binding data stored in the first storage unit 11. Reference numeral 13 denotes a second data storage unit that stores the combined data analyzed and classified by the data processing unit 12 in a predetermined format. The binding data stored in the second storage unit is provided in a desired format via the Internet line 4 in response to the request of the gene information user in FIG. It should be noted that the method for providing the combined data is not limited to the Internet line, and may be a tangible object such as a CD-ROM.

  The operation steps of the analysis system 1 will be described again with reference to the flowchart of FIG. First, in S <b> 1, medical information corresponding to genetic information including image data is acquired from the genetic information provider 2 via the Internet line 3. Next, in S2, the medical information corresponding to the gene information is stored in the first storage unit as one-to-one combined data. Next, in S3, the combined data is read out and classified and arranged based on the image data or document data. Next, in S3, the data processing unit 12 reads the combined data from the first data storage unit 11, and classifies and organizes based on the image data or document data included in the combined data. Next, in S4, the combined data arranged in the data processing unit 12 is stored in the second storage unit. In S5, the combined data is selected and provided in response to a request from the gene information user 5.

  In S3, in order to efficiently process the image data, an image processing function using artificial intelligence (AI) or a natural language processing function can be added to the data processing unit 12 to perform more advanced analysis. In S4, the combined data including the image information may be organized in a desired group such as a disease name or patient attribute included in the combined data, and the data may be stored in the second data storage unit 13.

Embodiment 2. FIG.
FIG. 4 is an overall configuration diagram showing a usage state of the gene information analysis system according to the second exemplary embodiment of the present invention. In FIG. 4, reference numeral 1 denotes an analysis system that analyzes and accumulates gene information. Reference numeral 2 denotes gene information providers such as medical institutions and researchers. Reference numeral 3 denotes an Internet line that collects gene information from the gene information provider 2 and transmits it to the analysis system 1. Reference numeral 4 denotes an Internet line for transmitting gene information sorted and classified by the analysis system 1 to the gene information user 5 as a user. Reference numeral 14 denotes a microarray analysis program stored in the analysis system 1. For example, software such as “Simple Array Analyzer” can be applied to the stored microarray analysis program, as in the first embodiment.

  Further, the gene information analysis system 1 is provided with the function of artificial intelligence 15, and when classifying and organizing data, image analysis of gene information and natural language processing can be performed. Further, when performing these, deep learning may be performed.

  In FIG. 4, when the gene information provider 2 accesses the analysis system 1 through the Internet line 3, the microarray analysis program 14 is downloaded to a computer or the like owned by the gene information provider 2, and the gene information provider 2 Can analyze numerical data, convert genetic information into image data, and visualize it.

  Gene information including data imaged using the microarray analysis program 14 is sent to the analysis system 1 in the same manner as in the first embodiment, organized and accumulated, and then requested by the gene information user 5 Provided. At this time, the administrator of the analysis system 1 may employ a business model that can request the provision of imaged data from the gene information provider 2 as a price for providing the microarray analysis program 14.

  In the second embodiment, the gene information provider 2 downloads the microarray analysis program 14 from the analysis system 1 to its own computer and uses it. However, the computer of the gene information provider 2 and the analysis system 1 are connected to the Internet line. The microarray analysis program 14 may be used as a configuration of a web system or a server-and-client system connected by 3.

  This invention is used for diagnosis and treatment of diseases and development of pharmaceuticals by collecting genetic information, analyzing and organizing it, and providing it to medical personnel, pharmaceutical manufacturers, IT companies and the like.

1 Gene Information Analysis System 2 Gene Information Provider 3 Internet Line 4 Internet Line 5 Gene Information User 14 Microarray Analysis Program 15 Artificial Intelligence

Claims (10)

  Obtaining genetic information including image data and medical information corresponding to the genetic information from outside, classifying, organizing and storing the genetic information as combined data associated with the medical information, in response to an external request A genetic information analysis system characterized by providing binding data.   The gene information analysis system according to claim 1, wherein the gene information including the image includes character information including numerical values and gene information including one or both of a heat map and a cluster diagram.   The gene information analysis system classifies the binding data in a predetermined format by analyzing either or both of image information and character information included in the binding data. Item 3. The genetic information analysis system according to Item 2.   The genetic information is stored in the analysis system in a state of combined data that is combined with the clinical information corresponding to the genetic information in a one-to-one relationship. The gene information analysis system described in 1.   5. The gene information analysis system according to claim 4, wherein the binding data is classified and accumulated based on the image data of the gene information.   6. The gene according to claim 5, wherein the gene information analysis system has one or both of an image analysis function by artificial intelligence and a natural language processing function, and the classification and arrangement of the image data is performed by the artificial intelligence. Information analysis system.   The gene information analysis system according to any one of claims 1 to 6, further comprising a microarray analysis program.   Gene information including image data and medical information corresponding to the genetic information are obtained from outside, the gene information is classified, organized and stored as combined data associated with the medical information, and external requests And providing the binding data according to the method.   Providing a genetic information provider with a microarray analysis program stored in a genetic information analysis system; obtaining genetic information including image data and medical information corresponding to the genetic information from the genetic information provider; A method for analyzing gene information, comprising: classifying, organizing, and storing genetic information as binding data associated with the medical information; and providing the binding data in response to a request from a genetic information user .   The provision of the microarray analysis program to the gene information provider is performed on the condition that the gene information provider provides the gene information and medical data to an administrator of the gene information analysis system. The gene information analysis method according to claim 9.