JP2018064873A - Warming device and transfusion system - Google Patents
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- JP2018064873A JP2018064873A JP2016206898A JP2016206898A JP2018064873A JP 2018064873 A JP2018064873 A JP 2018064873A JP 2016206898 A JP2016206898 A JP 2016206898A JP 2016206898 A JP2016206898 A JP 2016206898A JP 2018064873 A JP2018064873 A JP 2018064873A
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- 238000010792 warming Methods 0.000 title abstract description 11
- 238000010438 heat treatment Methods 0.000 claims abstract description 137
- 230000005540 biological transmission Effects 0.000 claims abstract 2
- 239000007788 liquid Substances 0.000 claims description 28
- 238000001802 infusion Methods 0.000 claims description 26
- 238000012546 transfer Methods 0.000 claims description 19
- 238000011144 upstream manufacturing Methods 0.000 claims description 10
- 239000012530 fluid Substances 0.000 claims description 4
- 239000008280 blood Substances 0.000 abstract 2
- 210000004369 blood Anatomy 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 239000010836 blood and blood product Substances 0.000 description 42
- 229940125691 blood product Drugs 0.000 description 42
- 238000010586 diagram Methods 0.000 description 6
- 238000009413 insulation Methods 0.000 description 5
- 238000009529 body temperature measurement Methods 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 239000003978 infusion fluid Substances 0.000 description 3
- 230000002159 abnormal effect Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 230000007423 decrease Effects 0.000 description 2
- 239000004023 fresh frozen plasma Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 210000002381 plasma Anatomy 0.000 description 2
- 239000011347 resin Substances 0.000 description 2
- 229920005989 resin Polymers 0.000 description 2
- 102000009027 Albumins Human genes 0.000 description 1
- 108010088751 Albumins Proteins 0.000 description 1
- 206010037660 Pyrexia Diseases 0.000 description 1
- 239000000853 adhesive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 210000003722 extracellular fluid Anatomy 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000020169 heat generation Effects 0.000 description 1
- 230000002949 hemolytic effect Effects 0.000 description 1
- 230000002631 hypothermal effect Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 125000006850 spacer group Chemical group 0.000 description 1
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- Resistance Heating (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
本発明は、加温装置及び輸液システムに関する。 The present invention relates to a warming device and an infusion system.
病院では患者に輸液する血液製剤の機能を維持するため、血液製剤を冷蔵保管している。血液製剤を患者に輸液する際には、患者の負担を軽減するため、血液製剤を適切な温度まで加温して輸液する場合がある。特に大量または危機的出血が発生した場合には、血液製剤を短時間で大量に輸液する必要があり、この際には低体温症を防止するため、血液製剤を患者体温まで急速に加温する必要がある。 In hospitals, blood products are stored refrigerated in order to maintain the function of blood products to be delivered to patients. When injecting a blood product to a patient, in order to reduce the burden on the patient, the blood product may be infused by heating to an appropriate temperature. In particular, when large-scale or critical bleeding occurs, it is necessary to infuse a large amount of blood product in a short time. In this case, the blood product is rapidly warmed to the patient's body temperature to prevent hypothermia. There is a need.
従来から、上述の大量または危機的出血が発生した患者の治療には、血液製剤を加温しながら患者に輸液する輸液システムが知られている。輸液システムには、加温流路に血液製剤を流し、その加温流路をヒータを熱源とする熱板によって加熱するものがある（特許文献１参照）。 Conventionally, an infusion system that infuses a blood product to a patient while warming a blood product is known for the treatment of a patient in which the above-described large-scale or critical bleeding has occurred. In some infusion systems, a blood product is allowed to flow through a heating channel, and the heating channel is heated by a hot plate using a heater as a heat source (see Patent Document 1).
上述の輸液システムにおいて、低温の血液製剤を急速に加温するためには、血液製剤を効率的に加温する必要がある。このために例えばヒータ温度を上げて、熱板と血液製剤の温度差を大きくすることが考えられる。しかしながら、血液製剤は、高温になると形態学的・機能的に異常または溶血となるため、異常または溶血にならないよう（好適な状態に）維持できる上限温度がある。この上限温度は４２℃程度であり、ヒータ温度を上げるにも限界がある。 In the above-mentioned infusion system, in order to rapidly warm a low-temperature blood product, it is necessary to warm the blood product efficiently. For this purpose, for example, it is conceivable to increase the temperature difference between the hot plate and the blood product by increasing the heater temperature. However, since a blood product becomes morphologically or functionally abnormal or hemolyzed at a high temperature, there is an upper limit temperature that can be maintained so that it does not become abnormal or hemolytic (in a suitable state). This upper limit temperature is about 42 ° C., and there is a limit to raising the heater temperature.
血液製剤のように上限温度が定められた液体を効率良く加温するために、熱板面内のヒーター部の電力を下流側加温部より上流側加温部の方を大きくする方法がある（特許文献２参照）。 In order to efficiently heat a liquid whose upper limit temperature is determined such as a blood product, there is a method in which the electric power of the heater part in the hot plate surface is made larger in the upstream heating part than in the downstream heating part. (See Patent Document 2).
しかしながら、上記方法のように加温流路の位置に応じてヒータ電力を変えても、熱板面内で熱が伝達してしまうと、熱板面内の温度制御ができず、十分に加温効率を上げることができない。 However, even if the heater power is changed according to the position of the heating flow path as in the above method, if the heat is transferred within the hot plate surface, the temperature control within the hot plate surface cannot be performed and sufficient heating is performed. The temperature efficiency cannot be increased.
本出願はかかる点に鑑みてなされたものであり、血液製剤などの輸液用の液体を効率的に加温できる加温装置及び輸液システムを提供することをその目的の一つとする。 The present application has been made in view of such a point, and an object thereof is to provide a warming device and an infusion system capable of efficiently warming a liquid for infusion such as a blood product.
本発明者らは、鋭意検討した結果、熱板が、加温流路における互いに隣接する流路の各々が配置される熱板領域同士の間で熱が伝達することを抑制する構造を有すること等により、上記問題を解決できることを見出し、本発明を完成するに至った。 As a result of intensive studies, the present inventors have a structure in which the heat plate suppresses heat transfer between the heat plate regions in which each of the channels adjacent to each other in the heating channel is disposed. As a result, the inventors have found that the above problem can be solved, and have completed the present invention.
すなわち、本発明は以下の態様を含む。
（１）輸液用の液体を加温する加温装置であって、熱板と、前記熱板面内に配置され、前記流体が流れる加温流路と、を有し、前記熱板は、前記加温流路における互いに隣接する流路の各々が配置される熱板領域同士の間で熱が伝達することを抑制する構造を有する、加温装置。
（２）前記熱板には、前記熱の伝達を抑制するスリットが設けられている、（１）に記載の加温装置。
（３）前記加温流路は、往路と復路を有する往復路を複数横に並べて繋げた構造を有し、前記スリットは、前記複数の往復路の互いに隣接する少なくとも一つの往路と復路の間に対応する位置に設けられている、（２）に記載の加温装置。
（４）前記スリットは、前記加温流路の少なくとも最上流の往復路の往路と復路の間に対応する位置に設けられている、（３）に記載の加温装置。
（５）前記熱板面内には、ヒータが配置され、前記熱板は、前記ヒータが配置される領域とその他の領域との間で熱が伝達することを抑制する構造を有する、（１）〜（４）のいずれかに記載の加温装置。
（６）前記熱板には、前記ヒータが配置される領域とその他の領域との間で熱が伝達することを抑制するスリットが設けられている、（５）に記載の加温装置。
（７）輸液用の液体を加温する加温装置であって、前記液体が流れる加温流路と、ヒータと、第１の面に前記ヒータが配置され、第２の面に前記加温流路が配置され、前記ヒータの熱を前記加温流路に供給する熱板と、を有し、前記熱板は、前記ヒータが配置される領域とその他の領域との間で熱が伝達することを抑制する構造を有する、加温装置。
（８）前記熱板には、前記熱の伝達を抑制するスリットが形成されている、（７）に記載の加温装置。
（９）前記熱板のその他の領域には、前記加温流路の入口部の温度を測定する非接触式温度センサ、又は前記加温流路の出口部の温度を測定する非接触式温度センサの少なくともいずれかが設けられている、（７）又は（８）に記載の加温装置。
（１０）（１）〜（９）のいずれかに記載の加温装置を備えた、輸液システム。
That is, the present invention includes the following aspects.
(1) A heating device for heating a liquid for infusion, comprising: a heating plate; a heating channel disposed in the surface of the heating plate, through which the fluid flows; The heating apparatus which has a structure which suppresses that a heat | fever transfers between the hotplate area | regions where each of the mutually adjacent flow path in the said heating flow path is arrange | positioned.
(2) The heating device according to (1), wherein the heat plate is provided with a slit for suppressing the heat transfer.
(3) The heating flow path has a structure in which a plurality of round trip paths having an outward path and a return path are arranged side by side, and the slit is between at least one of the plurality of round trip paths adjacent to each other. The heating device according to (2), provided at a position corresponding to.
(4) The heating device according to (3), wherein the slit is provided at a position corresponding to at least a forward path and a return path of the most upstream reciprocating path of the heating flow path.
(5) A heater is disposed in the hot plate surface, and the hot plate has a structure that suppresses heat transfer between a region where the heater is disposed and other regions. ) To (4).
(6) The heating apparatus according to (5), wherein the heat plate is provided with a slit for suppressing heat transfer between a region where the heater is disposed and another region.
(7) A heating device for heating a liquid for infusion, wherein the heater is disposed on a first surface and the heating channel through which the liquid flows, the heater on the second surface And a heat plate that supplies heat from the heater to the heating flow channel, and the heat plate transfers heat between a region where the heater is disposed and another region. A heating device having a structure that suppresses this.
(8) The heating apparatus according to (7), wherein the heat plate is formed with a slit for suppressing the heat transfer.
(9) In the other area of the hot plate, a non-contact temperature sensor that measures the temperature of the inlet of the heating channel, or a non-contact temperature that measures the temperature of the outlet of the heating channel The heating device according to (7) or (8), wherein at least one of the sensors is provided.
(10) An infusion system including the heating device according to any one of (1) to (9).
本発明によれば、輸液用の液体を効率的に加温する加温装置及び輸液システムを提供することができる。 ADVANTAGE OF THE INVENTION According to this invention, the heating apparatus and infusion system which heat the liquid for infusion efficiently can be provided.
以下、図面を参照して、本発明の好ましい実施の形態について説明する。なお、同一の要素には同一の符号を付し、重複する説明を省略する。また、上下左右等の位置関係は、特に断らない限り、図面に示す位置関係に基づくものとする。さらに、図面の寸法比率は、図示の比率に限定されるものではない。また、以下の実施の形態は、本発明を説明するための例示であり、本発明はこの実施の形態に限定されるものではない。 Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings. In addition, the same code | symbol is attached | subjected to the same element and the overlapping description is abbreviate | omitted. Further, the positional relationship such as up, down, left and right is based on the positional relationship shown in the drawings unless otherwise specified. Furthermore, the dimensional ratios in the drawings are not limited to the illustrated ratios. Moreover, the following embodiment is an illustration for explaining the present invention, and the present invention is not limited to this embodiment.
図１は、輸液システム１の構成の一例を示す。図１に示すように輸液システム１は、輸液用の液体としての血液製剤を収容する液体容器１０と、血液製剤を加温する加温装置１１と、血液製剤中の気泡を除去する気泡除去チャンバ１２と、液体容器１０と加温装置１１を接続する第１の流路１３と、加温装置１１と気泡除去チャンバ１２を接続する第２の流路１４と、気泡除去チャンバ１２と患者に輸液を行う輸液部１５を接続する第３の流路１６と、気泡除去チャンバ１２と液体容器１０を接続する第４の流路１７と、第１の流路１３に設けられた第１のポンプ１８と、第３の流路１６に設けられた第２のポンプ１９と、制御装置２０等を備えている。 FIG. 1 shows an example of the configuration of an infusion system 1. As shown in FIG. 1, an infusion system 1 includes a liquid container 10 that contains a blood product as an infusion liquid, a heating device 11 that heats the blood product, and a bubble removal chamber that removes air bubbles in the blood product. 12, a first flow path 13 that connects the liquid container 10 and the heating device 11, a second flow path 14 that connects the heating device 11 and the bubble removal chamber 12, an infusion solution to the bubble removal chamber 12 and the patient. A third flow path 16 for connecting the infusion part 15 for performing the above, a fourth flow path 17 for connecting the bubble removal chamber 12 and the liquid container 10, and a first pump 18 provided in the first flow path 13. And a second pump 19 provided in the third flow path 16, a control device 20, and the like.
液体容器１０は、例えば血液製剤の供給源となる液体バッグ３０に接続されている。液体容器１０には、第１の流路１３に流出する血液製剤の不要成分を除去するフィルター３１が設けられている。液体容器１０は、例えば樹脂製であり、例えば０．５Ｌ以上の容量を有している。 The liquid container 10 is connected to a liquid bag 30 serving as a blood product supply source, for example. The liquid container 10 is provided with a filter 31 that removes unnecessary components of the blood product flowing out to the first flow path 13. The liquid container 10 is made of resin, for example, and has a capacity of 0.5 L or more, for example.
図１に示すように気泡除去チャンバ１２の上部に第２の流路１４と第４の流路１７が接続され、気泡除去チャンバ１２の下部に第３の流路１６が接続されている。 As shown in FIG. 1, the second flow path 14 and the fourth flow path 17 are connected to the upper part of the bubble removal chamber 12, and the third flow path 16 is connected to the lower part of the bubble removal chamber 12.
第１の流路１３、第２の流路１４、第３の流路１６及び第４の流路１７は、軟質の可撓性のあるチューブにより構成されている。 The 1st flow path 13, the 2nd flow path 14, the 3rd flow path 16, and the 4th flow path 17 are comprised with the soft flexible tube.
第１のポンプ１８及び第２のポンプ１９には、例えばチューブポンプが用いられる。第１のポンプ１８及び第２のポンプ１９は、例えば１００ｍＬ／ｍｉｎ以上、好ましくは
２５０ｍＬ／ｍｉｎ以上、さらに好ましくは５００ｍＬ／ｍｉｎ以上の送液能力を有する。第１のポンプ１８及び第２のポンプ１９の動作は、制御装置２０により制御される。
As the first pump 18 and the second pump 19, for example, a tube pump is used. The first pump 18 and the second pump 19 have a liquid feeding capacity of, for example, 100 mL / min or more, preferably 250 mL / min or more, and more preferably 500 mL / min or more. The operations of the first pump 18 and the second pump 19 are controlled by the control device 20.
制御装置２０は、例えば汎用コンピュータであり、メモリに記録されたプログラムをＣＰＵで実行することにより、加温装置１１、第１のポンプ１８、第２のポンプ１９等を制御して、輸液システム１の輸液動作を実行できる。 The control device 20 is, for example, a general-purpose computer, and controls the heating device 11, the first pump 18, the second pump 19, and the like by executing a program recorded in the memory by the CPU, and thereby the infusion system 1 Infusion operation can be performed.
加温装置１１は、図２及び図３に示すように血液製剤が流れる加温流路４０を有する加温部４１と、加温流路４０に接触して給熱する給熱部４２と、断熱部４３を備えている。 As shown in FIGS. 2 and 3, the heating device 11 includes a heating unit 41 having a heating channel 40 through which a blood product flows, a heating unit 42 that supplies heat in contact with the heating channel 40, The heat insulation part 43 is provided.
加温部４１、給熱部４２及び断熱部４３は、すべて方形の板状に形成され、積層されている。積層構造の中央に加温部４１が配置され、加温部４１の両側に給熱部４２が配置され、その外側に断熱部４３が配置されている。加温部４１の周囲には、両側の給熱部４２の間に加温部４１を設置するスペースを確保するためのスペーサ４４が設けられている。 The heating unit 41, the heat supply unit 42, and the heat insulation unit 43 are all formed in a rectangular plate shape and stacked. The heating part 41 is arrange | positioned in the center of a laminated structure, the heat supply part 42 is arrange | positioned at the both sides of the heating part 41, and the heat insulation part 43 is arrange | positioned on the outer side. Around the heating unit 41, a spacer 44 is provided for securing a space for installing the heating unit 41 between the heat supply units 42 on both sides.
加温部４１は、可撓性のある樹脂製であり、図４に示すように方形の板状に形成されている。加温流路４０は、例えば可撓性のあるチューブ状に構成され、加温部４１内で蛇行するように形成されている。すなわち、加温流路４０は、複数の往復路を横に並べて繋げた形状を有している。本実施の形態では、加温流路４０は、例えば流路幅がほぼ等しい６つの往復路５０、５１、５２、５３、５４、５５を有している。加温流路４０の入口部５６と出口部５７は、例えば加温部４１の同一方向の端部に設けられている。 The heating unit 41 is made of a flexible resin and is formed in a square plate shape as shown in FIG. The heating channel 40 is configured in a flexible tube shape, for example, and is formed to meander in the heating unit 41. That is, the heating channel 40 has a shape in which a plurality of reciprocating paths are arranged side by side. In the present embodiment, the heating channel 40 has, for example, six reciprocating paths 50, 51, 52, 53, 54, and 55 having substantially the same channel width. The inlet portion 56 and the outlet portion 57 of the heating channel 40 are provided at, for example, end portions of the heating portion 41 in the same direction.
加温流路４０は、２００ｃｍ2以上の流路面積を有している。なお、「流路面積」とは、熱媒体（熱板６０）と接触する部分の面積である。また、加温流路４０のチューブの壁は、０．４ｍｍ以下、好ましくは０．３ｍｍ以下、さらに好ましくは０．２ｍｍ以下の厚さを有している。 The heating channel 40 has a channel area of 200 cm 2 or more. The “flow channel area” is an area of a portion in contact with the heat medium (heat plate 60). Moreover, the wall of the tube of the heating channel 40 has a thickness of 0.4 mm or less, preferably 0.3 mm or less, and more preferably 0.2 mm or less.
給熱部４２は、図２及び図３に示すように熱板６０と、給電により発熱する所定パターンのヒータ６１を有している。熱板６０は、例えば加温部４１と同一形状の方形の板状に形成されている。ヒータ６１は、熱板６０の第１の面６０ａに設けられ、加温流路４０は、熱板６０の第２の面６０ｂに接触している。よって、ヒータ６１の熱は、熱板６０を介して加温流路４０に伝達する。 As shown in FIGS. 2 and 3, the heat supply unit 42 includes a heat plate 60 and a heater 61 having a predetermined pattern that generates heat by power feeding. The hot plate 60 is formed, for example, in the shape of a square plate having the same shape as the heating unit 41. The heater 61 is provided on the first surface 60 a of the hot plate 60, and the heating channel 40 is in contact with the second surface 60 b of the hot plate 60. Therefore, the heat of the heater 61 is transmitted to the heating channel 40 via the hot plate 60.
図５に示すようにヒータ６１は、熱板６０上に所定パターンに形成されている。ヒータ６１は、電源装置６２により給電されて発熱する。 As shown in FIG. 5, the heater 61 is formed in a predetermined pattern on the hot plate 60. The heater 61 is heated by the power supply device 62 and generates heat.
ヒータ６１は、図６に示すように加熱流路４０に対応するパターンを有している。ヒータ６１は、例えば加温流路４０の複数の往復路５０〜５５に沿った複数の領域に区分され、発熱量（ヒータ電力）が上流側の領域から下流側の領域に向けて段階的に減少するように配置されている。ヒータ６１は、例えば７つの領域Ｒ１〜Ｒ７に区分されている。例えば入口部５６に近い最上流の往復路５０において、３つの領域Ｒ１〜Ｒ３に区画されている。このうち、往路５０ａが２つの領域Ｒ１、Ｒ２に区画され、復路５０ｂが一つの領域Ｒ３になっている。往復路５１（往路５１ａ、復路５１ｂ）が一つの領域Ｒ４になっており、往復路５２（往路５２ａ、復路５２ｂ）と往復路５３の往路５３ａが一つの領域Ｒ５になっている。また、往復路５３の復路５３ｂと往復路５４の往路５４ａが一つの領域Ｒ６になっており、往復路５４の復路５４ｂと往復路５５（往路５５ａ、復路５５ｂ）が一つの領域Ｒ７になっている。 The heater 61 has a pattern corresponding to the heating flow path 40 as shown in FIG. The heater 61 is divided into, for example, a plurality of regions along the plurality of reciprocating paths 50 to 55 of the heating channel 40, and the heat generation amount (heater power) is gradually increased from the upstream region to the downstream region. It is arranged to decrease. The heater 61 is divided into, for example, seven regions R1 to R7. For example, in the most upstream reciprocating path 50 close to the inlet portion 56, it is divided into three regions R1 to R3. Of these, the forward path 50a is divided into two areas R1 and R2, and the return path 50b is a single area R3. The round-trip path 51 (forward path 51a, return path 51b) is one area R4, and the round-trip path 52 (forward path 52a, return path 52b) and the forward path 53a of the round-trip path 53 are one area R5. Further, the return path 53b of the round-trip path 53 and the forward path 54a of the round-trip path 54 constitute one area R6, and the return path 54b and the round-trip path 55 (forward path 55a, return path 55b) of the round-trip path 54 constitute one area R7. Yes.
ヒータ６１は、例えば一続きの電熱線であり、各領域Ｒ１〜Ｒ７の発熱量Ｑは、電熱線の密度又は抵抗（例えば太さ、厚み、材質等）の少なくとも一方を変えることによって規定されている。 The heater 61 is, for example, a continuous heating wire, and the heating value Q of each of the regions R1 to R7 is defined by changing at least one of the density or resistance (for example, thickness, thickness, material, etc.) of the heating wire. Yes.
例えば往復路５０、５１、５２、５３及び往復路５４の往路５４ａ（領域Ｒ１〜Ｒ６）のヒータ６１は、加温流路４０に沿って加温流路４０上に配置されている。この領域Ｒ１〜Ｒ６のヒータ６１は、上流側から下流側に向けて加温流路４０上を矩形状に蛇行して延設されている。この領域Ｒ１〜Ｒ６のヒータ６１は、平面から見て加温流路４０の幅からはみ出ていない。 For example, the heaters 61 of the reciprocating paths 50, 51, 52, 53 and the forward path 54 a (regions R 1 to R 6) of the reciprocating path 54 are arranged on the heating flow path 40 along the heating flow path 40. The heaters 61 in the regions R1 to R6 extend from the upstream side to the downstream side by meandering in a rectangular shape on the heating channel 40. The heaters 61 in the regions R1 to R6 do not protrude from the width of the heating channel 40 when viewed from the plane.
往復路５４の復路５４ｂと往復路５５（領域Ｒ７）のヒータ６１は、３つの流路に亘り矩形状に蛇行している。 The return path 54b of the reciprocating path 54 and the heater 61 of the reciprocating path 55 (region R7) meander in a rectangular shape over the three flow paths.
図７は、熱板６０に形成されたスリットの配置例を示す説明図であり、図８は、熱板６０のスリットと、加温流路４０及びヒータ６１の位置関係を示す説明図である。熱板６０には、図７及び図８に示すように加温流路４０における互いに隣接する流路の各々が配置された熱板領域同士の間で熱が伝達することを抑制する構造としてのスリット７０が設けられている。例えば図８に示すようにスリット７０は、すべての往復路５０〜５５の隣り合う往路と復路の間に対応する位置に設けられている。よって、スリット７０は、往復路５０〜５５の往路及び復路の方向（図８の左右方向）に直線状に延びており、その直角方向（図８の上下方向）に平行に並べて設けられている。各スリット７０は、例えば長手方向の中央に繋ぎ部７１を備えている。 FIG. 7 is an explanatory diagram showing an example of the arrangement of slits formed in the hot plate 60, and FIG. 8 is an explanatory diagram showing the positional relationship between the slits of the hot plate 60, the heating channel 40 and the heater 61. . As shown in FIG. 7 and FIG. 8, the heat plate 60 has a structure that suppresses heat transfer between the heat plate regions in which the channels adjacent to each other in the heating channel 40 are arranged. A slit 70 is provided. For example, as shown in FIG. 8, the slit 70 is provided at a position corresponding to between the adjacent forward and return paths of all the round-trip paths 50 to 55. Therefore, the slit 70 extends linearly in the forward and backward directions (left and right direction in FIG. 8) of the reciprocating paths 50 to 55, and is arranged in parallel in the perpendicular direction (vertical direction in FIG. 8). . Each slit 70 includes a connecting portion 71 in the center in the longitudinal direction, for example.
また、熱板６０には、図７及び図８に示すようにヒータ６１が設置される領域Ｓ１とその他の領域Ｓ２との間で熱が伝達することを抑制する構造としてのスリット８０が設けられている。スリット８０は、例えば熱板６０におけるヒータ６１が配置される方形領域Ｓ１とその周囲の外周領域Ｓ２との間に配置される。スリット８０は、方形領域Ｓ１の外周の四辺に沿った直線状に形成されている。スリット８０は、断続的に形成され、複数の繋ぎ部８１を備えている。 Further, as shown in FIGS. 7 and 8, the hot plate 60 is provided with a slit 80 as a structure for suppressing heat transfer between the region S1 where the heater 61 is installed and the other region S2. ing. The slit 80 is disposed, for example, between the rectangular region S1 where the heater 61 in the hot plate 60 is disposed and the outer peripheral region S2 around it. The slit 80 is formed in a straight line shape along the four sides of the outer periphery of the rectangular region S1. The slit 80 is formed intermittently and includes a plurality of connecting portions 81.
スリット７０、８０は、例えばヒータ６１のある位置に重ならないように配置されている。スリット７０、８０は、有底の溝状に形成されていてもよいし、貫通していてもよい。また、繋ぎ部７１及び繋ぎ部８１は、繋ぎ部を通じた熱移動を抑制するため、図９に示すようにヒータ６１から可能な限り離れた位置に配置してもよい。 The slits 70 and 80 are arranged so as not to overlap, for example, a certain position of the heater 61. The slits 70 and 80 may be formed in a bottomed groove shape or may penetrate therethrough. Further, the connecting portion 71 and the connecting portion 81 may be arranged at a position as far as possible from the heater 61 as shown in FIG. 9 in order to suppress heat transfer through the connecting portion.
次に、以上のように構成された輸液システム１の動作について説明する。先ず、図１に示すように、低温の血液製剤が貯留された液体バッグ３０が液体容器１０に接続され、液体バッグ３０の血液製剤が液体容器１０内に貯留される。その後第１のポンプ１８と第２のポンプ１９が作動し、液体容器１０の血液製剤が第１の流路１３を通って加温装置１１に送られる。加温装置１１では、血液製剤が加温流路４０を通過し、その際にヒータ６１を熱源とする熱板６０により血液製剤が体温に近い所定の温度に加温される。 Next, operation | movement of the infusion system 1 comprised as mentioned above is demonstrated. First, as shown in FIG. 1, the liquid bag 30 in which a low-temperature blood product is stored is connected to the liquid container 10, and the blood product in the liquid bag 30 is stored in the liquid container 10. Thereafter, the first pump 18 and the second pump 19 are operated, and the blood product in the liquid container 10 is sent to the heating device 11 through the first flow path 13. In the heating device 11, the blood product passes through the heating channel 40, and at that time, the blood product is heated to a predetermined temperature close to the body temperature by the hot plate 60 using the heater 61 as a heat source.
この際、ヒータ６１は、発熱量が加温流路４０の上流側から下流側に向けて減少するように熱板６０に熱を与える。この結果、熱板６０は、加温流路４０の上流部に対応する位置において高い温度が維持され、加温流路４０に入り込んだ低温の血液製剤は、熱板６０との温度差により効率的に急速に加温される。血液製剤は加温流路４０を流れながら所望の温度まで加温される。この際、熱板６０では、スリット７０、８０により熱板６０の面内の熱の移動が抑制される。 At this time, the heater 61 applies heat to the hot plate 60 so that the amount of generated heat decreases from the upstream side to the downstream side of the heating channel 40. As a result, the hot plate 60 is maintained at a high temperature at a position corresponding to the upstream portion of the heating channel 40, and the low-temperature blood product that has entered the heating channel 40 is more efficient due to the temperature difference from the hot plate 60. Warms rapidly. The blood product is heated to a desired temperature while flowing through the heating channel 40. At this time, in the hot plate 60, the movement of heat in the surface of the hot plate 60 is suppressed by the slits 70 and 80.
加温装置１１で加温された血液製剤は、第２の流路１４を通過し、気泡除去チャンバ１２に流入する。その後、血液製剤は、第２のポンプ１９により第３の流路１６を通過し、輸液部１５から患者に輸液される。患者への輸液量は、第２のポンプ１９の液送流量を調整することにより制御される。 The blood product heated by the heating device 11 passes through the second flow path 14 and flows into the bubble removal chamber 12. Thereafter, the blood product passes through the third flow path 16 by the second pump 19 and is infused from the infusion part 15 to the patient. The amount of liquid delivered to the patient is controlled by adjusting the liquid flow rate of the second pump 19.
加温装置１１において血液製剤中に生じた気泡は、気泡除去チャンバ１２で捕捉される。気泡除去チャンバ１２内の一部の血液製剤と気体は、第４の流路１７を通って液体容器１０に戻される。この第４の流路１７を通過する気体を含む流体の流量は、第１のポンプ１８の送液流量を調整することにより制御される。例えば第１のポンプ１８の送液流量を増やすことにより、気泡除去チャンバ１２から第４の流路１７に流出する流体の流量が増え、第１のポンプ１８の送液流量を減らすことにより、気泡除去チャンバ１２から第４の流路１７に流出する液体の流量が減る。 Bubbles generated in the blood product in the warming device 11 are captured by the bubble removal chamber 12. Some blood products and gas in the bubble removal chamber 12 are returned to the liquid container 10 through the fourth flow path 17. The flow rate of the fluid containing the gas passing through the fourth flow path 17 is controlled by adjusting the liquid feed flow rate of the first pump 18. For example, by increasing the flow rate of the first pump 18, the flow rate of the fluid flowing out from the bubble removal chamber 12 to the fourth flow path 17 increases, and by decreasing the flow rate of the first pump 18, The flow rate of the liquid flowing out from the removal chamber 12 to the fourth flow path 17 is reduced.
本実施の形態によれば、スリット７０により加温流路４０における互いに隣接する流路の各々が配置される熱板領域同士の間で熱が伝達することを抑制できるので、ヒータ６１の各領域Ｒ１〜Ｒ７の熱が、対応する加温流路４０の各部分に的確に供給され、血液製剤を効率的に加温することができる。 According to the present embodiment, it is possible to prevent heat from being transferred between the hot plate regions in which each of the channels adjacent to each other in the heating channel 40 is arranged by the slit 70, so that each region of the heater 61 The heat of R1 to R7 is accurately supplied to each part of the corresponding heating channel 40, and the blood product can be efficiently heated.
また、スリット８０により、熱が熱板６０のヒータ６１のある領域Ｓ１からヒータ６１のない領域Ｓ２に拡散することが抑制され、またヒータ６１のない領域Ｓ２からヒータ６１のある領域Ｓ１に入り込むことが抑制される。これにより、ヒータ６１の外部との間の熱のやり取りが少なくなり、ヒータ６１の各領域Ｒ１〜Ｒ７から加温流路４０の各部分に供給される熱量を厳格に制御することができる。また、例えば加温流路４０において血液製剤の送液を停止した時に、ヒータ６１のない領域Ｓ２からヒータ６１のある領域に熱が流入して加温流路４０の血液製剤が過剰に加温されることを抑制できる。なお、熱板６０には、スリット７０又はスリット８０の一方のみが形成されていてもよい。 Further, the slit 80 prevents heat from diffusing from the region S1 where the heater 61 is present to the region S2 where the heater 61 is not present, and enters the region S1 where the heater 61 is present from the region S2 where the heater 61 is not present. Is suppressed. Thus, heat exchange with the outside of the heater 61 is reduced, and the amount of heat supplied from the regions R1 to R7 of the heater 61 to each part of the heating flow path 40 can be strictly controlled. Further, for example, when the blood product feeding is stopped in the heating channel 40, heat flows from the region S2 where there is no heater 61 into a region where the heater 61 is present, and the blood product in the heating channel 40 is excessively heated. Can be suppressed. Note that only one of the slit 70 or the slit 80 may be formed in the hot plate 60.
スリット７０は、往復路５０〜５５の互いに隣接する往路と復路の間に対応する位置に設けられているので、隣接する往路と復路の間の熱の伝達を適切に抑制できる。 Since the slit 70 is provided at a position corresponding to the reciprocal paths 50 to 55 between the adjacent forward path and the return path, heat transfer between the adjacent forward path and the return path can be appropriately suppressed.
スリット７０は、加温流路４０の最上流の往復路５０の往路５０ａと復路５０ｂの間に対応する位置に設けられているので、加温流路４０の上流部に対する熱の供給量を厳格に制御できる。この結果、加温流路４０に流入した直後の低温の血液製剤の加温を効率的に行うことができる。 Since the slit 70 is provided at a position corresponding to between the forward path 50a and the return path 50b of the most upstream reciprocating path 50 of the heating channel 40, the amount of heat supplied to the upstream portion of the heating channel 40 is strictly controlled. Can be controlled. As a result, it is possible to efficiently heat the low-temperature blood product immediately after flowing into the heating channel 40.
上記実施の形態において、図１０、図１１に示すように熱板６０のヒータ６１のない領域Ｓ２には、加温流路４０の入口部５６の血液製剤の温度を測定する非接触式温度センサ９０と加温流路４０の出口部５７の血液製剤の温度を測定する非接触式温度センサ９１が設けられていてもよい。かかる場合、非接触式温度センサ９０、９１の温度測定結果が、制御装置２０に出力され、制御装置２０が、その温度測定結果に基づいてヒータ６１の発熱量を制御する。これにより、加温流路４０で加温される血液製剤の温度を厳格に制御できる。また、熱板６０の温度測定が行われる領域Ｓ２が、スリット８０によりヒータ６１のある領域Ｒ１と分けられており、温度測定が行われる熱板６０の領域Ｒ２がヒータ６１の熱の影響を受けにくい。この結果、非接触式温度センサ９０、９１が、例えば熱板６０から放射される赤外線を拾うことが抑制され、非接触式温度センサ９０、９１が入口部５６、出口部５７の血液製剤の温度を正確に測定できる。 In the above embodiment, as shown in FIGS. 10 and 11, the non-contact temperature sensor that measures the temperature of the blood product at the inlet portion 56 of the heating channel 40 is provided in the region S <b> 2 without the heater 61 of the hot plate 60. 90 and a non-contact temperature sensor 91 for measuring the temperature of the blood product at the outlet 57 of the heating channel 40 may be provided. In such a case, the temperature measurement results of the non-contact temperature sensors 90 and 91 are output to the control device 20, and the control device 20 controls the amount of heat generated by the heater 61 based on the temperature measurement results. Thereby, the temperature of the blood product heated in the heating channel 40 can be strictly controlled. The region S2 where the temperature measurement of the hot plate 60 is performed is separated from the region R1 where the heater 61 is provided by the slit 80, and the region R2 of the hot plate 60 where the temperature measurement is performed is affected by the heat of the heater 61. Hateful. As a result, the non-contact temperature sensors 90 and 91 are suppressed from picking up infrared rays radiated from the hot plate 60, for example, and the non-contact temperature sensors 90 and 91 are the temperature of the blood product at the inlet portion 56 and the outlet portion 57. Can be measured accurately.
以上、添付図面を参照しながら本発明の好適な実施の形態について説明したが、本発明はかかる例に限定されない。当業者であれば、特許請求の範囲に記載された思想の範疇内において、各種の変更例または修正例に想到し得ることは明らかであり、それらについても当然に本発明の技術的範囲に属するものと了解される。 The preferred embodiments of the present invention have been described above with reference to the accompanying drawings, but the present invention is not limited to such examples. It is obvious for those skilled in the art that various modifications or modifications can be conceived within the scope of the idea described in the claims, and these naturally belong to the technical scope of the present invention. It is understood.
例えば上記実施の形態において、加温流路４０における互いに隣接する流路の各々が配置される熱板領域同士の間で熱が伝達することを抑制する構造がスリット７０であり、ヒータ６１が配置される領域Ｓ１とその他の領域Ｓ２との間で熱が伝達することを抑制する構造がスリット８０であったが、これに限られない。例えば図１２に示すように熱板６０に、スリット７０、８０と同様に形成された孔１００に、熱板６０よりも断熱性の高い材料１０１を埋め込むようにしてもよい。断熱性の高い材料１０１には、例えばヒータ６１と熱板６０を接着する際に用いる接着剤を用いてもよいし、ヒータ６１を熱板９０に溶着する際にヒータ６１が溶けてできる材料を用いてもよい。 For example, in the above-described embodiment, the structure that suppresses heat transfer between the hot plate regions in which each of the adjacent channels in the heating channel 40 is disposed is the slit 70, and the heater 61 is disposed. The structure that suppresses heat transfer between the region S1 and the other region S2 is the slit 80, but is not limited thereto. For example, as shown in FIG. 12, a material 101 having a higher heat insulating property than the hot plate 60 may be embedded in a hole 100 formed in the hot plate 60 in the same manner as the slits 70 and 80. For example, an adhesive used when the heater 61 and the hot plate 60 are bonded may be used as the material 101 having high heat insulating properties, or a material formed by melting the heater 61 when the heater 61 is welded to the hot plate 90. It may be used.
また、加温装置１１のヒータ６１の所定パターンは上記例に限られない。ヒータ６１が区分される領域の数は、７つに限られず、任意に選択できる。また、ヒータ６１が区分される境界の位置も任意に選択できる。加温流路４０の往復路の数や形状もこれに限られない。以上の実施の形態において、加温装置１１のヒータ６１は、加温流路４０の両側に設けられていたが、図１３に示すように加温流路４０の片側にのみ設けられていてもよい。すなわち、加温流路４０を有する加温部４１の一方側に、給熱部４２と断熱部４３が設けられ、他方側に断熱部４３が設けられていてもよい。輸液システム１で送液される輸液用の液体は血液製剤であったが、これに限られず、例えば新鮮凍結血漿(FFP)、アルブミン、細胞外液であってもよい。 Further, the predetermined pattern of the heater 61 of the heating device 11 is not limited to the above example. The number of areas into which the heater 61 is divided is not limited to seven and can be arbitrarily selected. Moreover, the position of the boundary where the heater 61 is divided can be arbitrarily selected. The number and shape of the reciprocating path of the heating channel 40 are not limited to this. In the above embodiment, the heaters 61 of the heating device 11 are provided on both sides of the heating channel 40, but may be provided only on one side of the heating channel 40 as shown in FIG. Good. That is, the heat supply part 42 and the heat insulation part 43 may be provided on one side of the heating part 41 having the heating channel 40, and the heat insulation part 43 may be provided on the other side. The infusion liquid to be delivered by the infusion system 1 is a blood product, but is not limited thereto, and may be, for example, fresh frozen plasma (FFP), albumin, or extracellular fluid.
本発明は、輸液用の液体を効率的に加温する加温装置及び輸液システムを提供する際に有用である。 INDUSTRIAL APPLICABILITY The present invention is useful when providing a warming device and an infusion system that efficiently heat a liquid for infusion.
１ 輸液システム
１１ 加温装置
４０ 加温流路
４１ 加温部
４２ 給熱部
５０〜５５ 往復路
６０ 熱板
６１ ヒータ
７０ スリット
８０ スリット
Ｒ１〜Ｒ７ 領域
DESCRIPTION OF SYMBOLS 1 Infusion system 11 Heating apparatus 40 Heating flow path 41 Heating part 42 Heating part 50-55 Reciprocating path 60 Heat plate 61 Heater 70 Slit 80 Slit R1-R7 area | region
Claims (10)
熱板と、
前記熱板面内に配置され、前記流体が流れる加温流路と、を有し、
前記熱板は、前記加温流路における互いに隣接する流路の各々が配置される熱板領域同士の間で熱が伝達することを抑制する構造を有する、加温装置。 A heating device for heating a liquid for infusion,
A hot plate,
A heating channel disposed in the hot plate surface and through which the fluid flows,
The heating plate is a heating device having a structure that suppresses heat transfer between hot plate regions in which the channels adjacent to each other in the heating channel are arranged.
前記スリットは、前記複数の往復路の互いに隣接する少なくとも一つの往路と復路の間に対応する位置に設けられている、請求項２に記載の加温装置。 The heating flow path has a structure in which a plurality of round trip paths having a forward path and a return path are arranged side by side and connected,
The heating device according to claim 2, wherein the slit is provided at a position corresponding to at least one of the plurality of reciprocating paths adjacent to each other between the forward path and the return path.
前記熱板は、前記ヒータが配置される領域とその他の領域との間で熱が伝達することを抑制する構造を有する、請求項１〜４のいずれかに記載の加温装置。 A heater is arranged in the hot plate surface,
The heating apparatus according to any one of claims 1 to 4, wherein the heat plate has a structure that suppresses heat transfer between a region where the heater is disposed and another region.
前記液体が流れる加温流路と、
ヒータと、
第１の面に前記ヒータが配置され、第２の面に前記加温流路が配置され、前記ヒータの熱を前記加温流路に供給する熱板と、を有し、
前記熱板は、前記ヒータが配置される領域とその他の領域との間で熱が伝達することを抑制する構造を有する、加温装置。 A heating device for heating a liquid for infusion,
A heating channel through which the liquid flows;
A heater,
The heater is disposed on a first surface, the heating channel is disposed on a second surface, and a heating plate that supplies heat of the heater to the heating channel;
The heating plate is a heating device having a structure that suppresses heat transfer between a region where the heater is disposed and another region.
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| Application Number | Priority Date | Filing Date | Title |
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| JP2016206898A JP6944242B2 (en) | 2016-10-21 | 2016-10-21 | Heating device and infusion system |
| DE112017005328.5T DE112017005328T5 (en) | 2016-10-21 | 2017-09-27 | Warming device and infusion system |
| US16/343,585 US11559636B2 (en) | 2016-10-21 | 2017-09-27 | Warming device and infusion system |
| PCT/JP2017/034982 WO2018074165A1 (en) | 2016-10-21 | 2017-09-27 | Warming device and infusion system |
| CN201780045088.0A CN109475704B (en) | 2016-10-21 | 2017-09-27 | Heating device and infusion system |
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| JP2016206898A JP6944242B2 (en) | 2016-10-21 | 2016-10-21 | Heating device and infusion system |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112089923A (en) * | 2020-10-19 | 2020-12-18 | 邢倩倩 | Infusion support capable of automatically and uniformly heating |
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|---|---|---|---|---|
| JPS5613386U (en) * | 1979-07-10 | 1981-02-04 | ||
| JPS57192565A (en) * | 1981-05-11 | 1982-11-26 | Extracorporeal Medical | Apparatus for heating or cooling liquid |
| JP2002146540A (en) * | 2000-11-14 | 2002-05-22 | Ebara Corp | Substrate heater |
| JP2015157041A (en) * | 2014-02-25 | 2015-09-03 | 株式会社メテク | Transfusion warmer |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5613386U (en) * | 1979-07-10 | 1981-02-04 | ||
| JPS57192565A (en) * | 1981-05-11 | 1982-11-26 | Extracorporeal Medical | Apparatus for heating or cooling liquid |
| JP2002146540A (en) * | 2000-11-14 | 2002-05-22 | Ebara Corp | Substrate heater |
| JP2015157041A (en) * | 2014-02-25 | 2015-09-03 | 株式会社メテク | Transfusion warmer |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112089923A (en) * | 2020-10-19 | 2020-12-18 | 邢倩倩 | Infusion support capable of automatically and uniformly heating |
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