JP2018017634A - Radionuclide manufacturing device, target device, and method for manufacturing radioactive agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a radionuclide manufacturing device which exhibits a high efficiency of cooling a target irradiated with a beam, without generating problems in the attachment thereof to an accelerator.SOLUTION: The radionuclide manufacturing device includes: an irradiation container 51 containing a target; and a buffer unit 53 connecting to the irradiation container 51, in which a target vaporized by application of a charged particles beam Pb can be diffused. The buffer unit 53 is longer in a lengthwise direction along the direction in which the charged particles beam Pb is applied than in a width direction perpendicular to the beam application direction.SELECTED DRAWING: Figure 5

Description

  The present invention relates to a radionuclide production apparatus, a target apparatus, and a method for producing a radiopharmaceutical.

Imaging of a nuclear medicine image is performed by introducing a radiopharmaceutical with a small amount of radionuclide as a mark into a patient's body and imaging the state in which the radiopharmaceutical collects in an organ or body tissue. As such a technique, for example, positron emission tomography (hereinafter also referred to as “PET”) is known. In PET, for example, a drug in which fluorine-18 ( ¹⁸ F) is added as a radionuclide to glucose ( ¹⁸ F-FDG: hereinafter, also simply referred to as “FDG”) is injected into a patient's body. Then, the FDG distribution in the body is photographed with a PET camera.

¹⁸ F is generated by irradiating a charged particle beam with H ₂ ¹⁸ O as a target to cause a nuclear reaction of ¹⁸ O (p, n) ¹⁸ F. The target H ₂ ¹⁸ O is relatively expensive, and the amount used is as small as 2 to 5 ml. In the radionuclide production apparatus, when a small amount of target is irradiated with a high-energy beam, the target irradiated with the beam boils and vaporizes. The boiling and vaporization of the target moves the target from the irradiation position of the beam, thereby reducing the efficiency of the nuclear reaction and causing a decrease in the yield of ¹⁸ F. On the other hand, the yield of ¹⁸ F increases by increasing the beam current of the beam energy, and the beam current tends to increase further. Therefore, the radionuclide production apparatus has a conflicting request to suppress boiling and vaporization of the target while being irradiated with a beam with a large current value.

Further, the target in the target device is generally enclosed in a container with a metal foil having a high melting point, high strength, and high corrosion resistance as a beam entrance window. When the pressure in the container increases due to boiling and vaporization of the target, high pressure is also applied to the foil.
By the way, since the beam passes through the foil and irradiates the target, the thickness of the foil is set so as to block the passage of the liquid and the gas and allow the passage of the beam. For this reason, when a larger capacity beam is incident, the thickness of the foil cannot be sufficiently increased to withstand the increase in pressure in the container, and the target apparatus may be damaged. ing.

Known techniques for suppressing boiling and vaporization of the target include those described in Patent Document 1, Patent Document 2, and Patent Document 3, for example. Among known techniques, the RI manufacturing apparatus described in Patent Document 1 supplies pressurized gas to the buffer unit to suppress boiling. However, the pressurized gas is known to reduce the cooling efficiency of the vaporized target. For this reason, in the invention described in Patent Document 1, the gas mixture of vaporized target and pressurized gas is separated in the cooling unit.
In the target device described in Patent Document 2, helium gas is supplied to the buffer portion communicating with the target accommodating portion to suppress boiling, and at the same time, the shape of the buffer portion is widened to increase the surface area of the buffer portion wall surface. The target's steam cooling capacity is increased. Patent Document 3 describes a target device having a first chamber in which a target is accommodated and a second chamber in which the volume is larger than that of the first chamber and a vaporized target is accommodated.

JP 2013-246131 A JP 2011-220930 A US Patent Application Publication No. 2016/0141062

However, in the known technique for suppressing the boiling and vaporization of the target, a mechanism for cooling the vaporized target is provided on the vertical plane of the beam incident on the target, so there is a limit to increasing the surface area of this mechanism. . In particular, when targeting H ₂ ¹⁸ O, a small cyclotron called a PET cyclotron is often used. A plurality of target devices are attached to the PET cyclotron, and an irradiation device is densely arranged at a particle beam extraction portion from the target device. Thus, increasing the volume of the target device, the number of the target device attachable to PET cyclotron is reduced, by the maintenance of the target such as, ¹⁸ F stable production of, hinder exposure problems operator It is possible.
On the other hand, the area A required for target cooling by using latent heat of evaporation (removal of condensation heat) is expressed by the following equation.
A = Q / (U · ΔT) Equation (1)
In the above formula (1), Q is the amount of heat input to the target device (W), U is the overall electric heat coefficient (W / m ² K), ΔT is the temperature difference (K) between the front and back of the member with respect to the area A To do. According to the equation (1), it is found that the surface area of the target device needs to be further increased when the material of the target device is made constant and the beam is set to a large current to increase the heat capacity.

From the above, it is necessary to increase the surface area for cooling without increasing the total volume of the target device in order to produce a large amount of radioisotopes in a short time using a high-current beam. . Also, in order to reduce the risk of foil damage, it is important for the target device to increase the cooling efficiency and not increase the internal pressure.
The present invention has been made in view of the above points, and does not hinder the attachment to the accelerator, and the radionuclide production apparatus, the target apparatus, and the radioactivity having high cooling efficiency of the target irradiated with the particle beam An object is to provide a method for producing a nuclide.

  The radionuclide production apparatus of the present invention is a radionuclide production apparatus that generates a radionuclide by irradiating a liquid target with a particle beam, the container containing the target, and a container that contains the target, A buffer part capable of diffusing the target vaporized by irradiation, wherein the buffer part has a shape that is longer in the length direction along the irradiation direction than in the width direction orthogonal to the irradiation direction of the particle beam. And

  The target apparatus of the present invention is a target apparatus of a radionuclide production apparatus that generates a radionuclide by irradiating a liquid target with a particle beam, and a container having a container for housing the target, and communicating with the container. A buffer part capable of diffusing the target vaporized by the irradiation of the particle beam, and the buffer part has a shape that is longer in the length direction along the irradiation direction than in the width direction orthogonal to the irradiation direction of the particle beam. It is characterized by having.

  The radiopharmaceutical production method of the present invention is a radiopharmaceutical production method for producing a radiopharmaceutical using the radionuclide produced by the radionuclide production apparatus, and a recovery step of collecting the radionuclide from the radionuclide production apparatus And a labeling step of labeling a labeled precursor compound using the radionuclide recovered in the recovery step.

The above-described present invention can provide a radionuclide production apparatus, a target apparatus, and a method for producing a radiopharmaceutical that do not hinder the attachment to the accelerator and have high cooling efficiency of the target irradiated with the beam.
That is, according to the above configuration, at least a part of the vaporized target diffuses into the buffer unit and is cooled. In order to increase the cooling efficiency of the target, it is advantageous that the buffer portion has a large surface area. As a method for increasing the surface area, it is conceivable to provide a plurality of buffer portions. According to the above configuration of the present invention, it is possible to increase the surface area of the target device by expanding the target device in the length direction without expanding the target device in the width direction. For this reason, even if it arranges multiple target apparatuses in the circumferential direction of the member which generate | occur | produces a particle beam, this invention can prevent the trouble in the attachment.

It is typical sectional drawing for demonstrating the radionuclide manufacturing apparatus of one Embodiment of this invention. It is a perspective view of the target device shown in FIG. FIG. 3 is a top view of the target device shown in FIG. 2. It is sectional drawing which follows the arrow AA shown in FIG. It is sectional drawing which follows the arrow BB shown in FIG. FIG. 4 is a cross-sectional view taken along the arrow line CC shown in FIG. 3. FIG. 4 is a schematic diagram illustrating a top view shape of the buffer unit illustrated in FIG. 3.

  Hereinafter, an embodiment of the present invention will be described with reference to the drawings. In the present embodiment, the same members are denoted by the same reference numerals in the drawings, and the description of the parts described above may be partially omitted. Moreover, the schematic diagrams of the present embodiment and the second embodiment are for explaining the function, the positional relationship, and the like, and do not accurately represent the dimensional shape.

[Radionuclide production equipment]
FIG. 1 is a schematic cross-sectional view for explaining the radionuclide production apparatus of this embodiment. The illustrated radionuclide production apparatus 1 includes an accelerator that generates a charged particle beam Pb, and a target apparatus that manufactures a radioisotope (hereinafter referred to as “RI”) upon irradiation with the charged particle beam Pb generated by the accelerator. And. The accelerator and the target device are attached in close contact with each other by bolts (not shown) or the like, and only the charged particle beam Pb enters the target device 5 from the accelerator 3.
Such a radionuclide production apparatus includes a self-shield (not shown) in order to prevent radiation leakage to the outside.

  The accelerator 3 is configured to generate the charged particle beam Pb by accelerating the incident particles. Various types of incident particles that constitute a particle beam that generates a nuclear reaction in the target material are used, and examples include protons, deuterons, α particles, ions, electrons, and photons. As the accelerator 3, an electrostatic accelerator, a circular accelerator such as a cyclotron or a synchrotron, a linear accelerator, or a microtron that combines a circular accelerator and a linear accelerator can be used, and it is selected according to the type and energy of incident particles. Is done.

In the radionuclide production apparatus of this embodiment, a plurality of target devices 5 are attached to one accelerator 3. In the example shown in FIG. 1, for example, four target devices are provided on the left and right sides of the accelerator 3 in a row in the direction toward the paper surface (the direction indicated by the Z axis in the drawing).
In such a radionuclide production apparatus, an existing one may be used for the accelerator 3 and the target apparatus may be replaced with one that increases the yield of the target product. At this time, if the surface area of the target device is simply increased in order to enhance the heat dissipation effect, there is a possibility that a plurality of target devices cannot be attached to the accelerator 3.
Here, all of the target devices 5 are arranged in the Z direction in the drawing. For this reason, even if the surface area of the target device 5 is increased in a direction other than the Z direction, the target device 5 can be attached to the accelerator 3.
In this embodiment, paying attention to the above points, the surface area of the target device 5 is increased in the direction other than the Z direction so as to eliminate the influence on the attachment to the accelerator 3 while enhancing the heat radiation effect.

In the radionuclide production apparatus of this embodiment, the accelerator generates a proton beam as the charged particle beam Pb. Then, the generated proton beam is irradiated to the target device 5 with an irradiation current value of 18 MeV, 50 μA to 100 μA or more.
The target device 5 of this embodiment holds H ₂ ¹⁸ O as a target. When the target is irradiated with the charged particle beam Pb, a nuclear reaction represented by ¹⁸ O (p, n) ¹⁸ F occurs between the target and the proton in the target device 5, and ¹⁸ F is generated as RI. . Such a nuclear reaction is represented by writing the target material on the left side, the product on the right side, and the incident particles and the particles popping out in parentheses.

The generated ¹⁸ F is sent to the synthesizer. The synthesizer synthesizes ¹⁸ F with a labeled precursor compound to produce FDG and the like.
Note that this embodiment is not limited to target Those in H ₂ ¹⁸ O. For example, H ₂ O can be used as a target, and ¹³ N can be generated by a nuclear reaction of ¹⁶ O (p, α) ¹³ N.

[Target device]
(overall structure)
Next, the overall configuration of the target device 5 of the present embodiment will be described.
FIG. 2 is a perspective view for explaining the target device 5 of the present embodiment. Note that all of the target devices 5 shown in FIG. 1 have the same configuration. For this reason, in the present embodiment, one target device 5 is described and replaced with the description of another target device 5. The X, Y, and Z coordinates shown in FIG. 2 coincide with the coordinate system shown in FIG.

The target device 5 is a target device of a radionuclide production apparatus that generates a radionuclide by irradiating a liquid target with the charged particle beam Pb. The target device 5 includes an irradiation container 51 that is a container for storing a liquid target, and a buffer unit 53 that communicates with the irradiation container 51 and has a space in which a target vaporized by irradiation with the charged particle beam Pb can diffuse. ing. The irradiation container 51 holds H ₂ ¹⁸ O as a target (not shown). The buffer unit 53 has a length direction (X direction along the drawing) along the irradiation direction of the charged particle beam Pb rather than a width direction (along the Z direction in FIG. 2) perpendicular to the irradiation direction of the charged particle beam Pb. ) Has a long shape.

The target device 5 is made of a metal material having excellent corrosion resistance such as niobium (Nb) or tantalum (Ta). The target device is manufactured by cutting a cylindrical mass of such a metal material having a diameter of 60 mm, or by diffusion bonding of a multi-layer disc with a flow path cut. The irradiation container 51 and the buffer part 53 are both spaces formed in the metal material lump by cutting the cylindrical lump. In the present embodiment, such a lump of metal material is hereinafter referred to as a “target body” 50. Niobium is an advantageous member in that the production of heteronuclides can be suppressed.
The target device 5 is attached to the accelerator 3 by a metal mounting fixture 2 such as aluminum. The mounting fixture 2 has frame bodies 21 and 23, and fixes the target device 5 to the accelerator 3 so that the target device 5 is sandwiched between the frame body 21 and the frame body 23. The frame body 21 and the frame body 23 are brought into close contact with each other using bolts or O-rings (not shown).
The frame 21 is provided with a beam entrance 31 through which the charged particle beam Pb irradiated from the accelerator 3 passes. At the boundary between the frame body 21 and the irradiation container 51, a foil 52 having a suitable thickness that does not allow air or water to pass through the charged particle beam Pb is provided. For the foil 52, for example, HAVAR (registered trademark), titanium, stainless steel or the like is used.
Although not shown in FIG. 2, a cooling water branch pipe 63 (see FIGS. 2, 3, and 6) through which the cooling water circulates is provided on the incident side of the charged particle beam Pb of the target device 5. A cooling water main pipe 60 (see FIGS. 4 and 5) is connected to the cooling water branch pipe 63, and cooling water is supplied to the cooling water branch pipe 63 from the outside through the cooling water main pipe 60. Is done.
The target device 5 includes a communication passage 57 that allows the irradiation container 51 and the buffer unit 53 to communicate with each other and keep the pressure of both constant (see FIGS. 3 and 5). By providing the communication path 57, the pressure from the upper end of the buffer unit 53 to the irradiation container 51 becomes equal, and the water level f1 of the target in the irradiation container 51 is constant regardless of the pressure values of the irradiation container 51 and the buffer unit 53. To be kept.

  FIG. 3 is a top view of the target device 5 shown in FIG. 2 as viewed from the + Y direction side. The top view of FIG. 3 is a partial schematic view, and the illustration of the cooling water main pipe 60 is omitted to make the shape of the irradiation container 51 easier to see. FIG. 4 is a cross-sectional view along the arrow AA shown in FIG. FIG. 5 is a cross-sectional view taken along the arrow BB shown in FIG. 6 is a cross-sectional view taken along the line CC shown in FIG.

As shown in FIG. 3, the target device 5 includes a fitting 71 and a pipe line 711 connected to the fitting 71. The fitting 71 and the pipe line 711 are configured to pass He gas or water through the buffer unit 53 and the irradiation container 51. The target device 5 includes a fitting 73 and a pipe line 731 connected to the fitting 73. The fitting 73 and the pipe line 731 are configured to recover a target including ¹⁸ F from the irradiation container 51.
In the present embodiment, the length in the X direction of the frame body 23 in the cross-sectional view shown in FIG. 4 is 46.00 mm, and the maximum length in the Z direction of the frame body 23 in the cross-sectional views shown in FIGS. 0.000 mm.

  Hereinafter, each of the above-described configurations will be described.

(Irradiation container)
As shown in FIG. 3, the irradiation container 51 is a cavity having a substantially isosceles triangle in a top view. In the irradiation container 51, as shown in FIG. 4, the cross-sectional area of the surface orthogonal to the incident direction of the charged particle beam Pb is directed to the irradiation direction of the charged particle beam Pb (the direction from the irradiation source toward the irradiation side). It has a shape that becomes smaller according to As shown in FIG. 4, the cross section of the irradiation container 51 is larger on the arrow BB shown in FIG. 3 than on the arrow CC. Moreover, the cross section of the irradiation container 51 is circular on the arrow BB shown in FIG. 3, but has an elliptical shape on the arrow CC shown in FIG.

The irradiation container 51 becomes narrower along the X direction (incident direction of the charged particle beam Pb). Such a shape is also referred to as a “cone shape” in the present embodiment. The cone shape is a shape designed according to the fact that the intensity of the charged particle beam Pb is strong at the center of the cross-sectional area perpendicular to the incident direction of the beam and attenuates as it travels through the target. By making the irradiation container 51 into a cone shape, a charged particle beam Pb having a high intensity is irradiated to a portion with a large amount of target. Thereby, a high heat removal effect can be obtained by the two points of the decrease in the heat generation amount per unit area in the irradiation container 51 and the increase in the area of the cooling surface. The amount of the target accommodated in the irradiation container 51 is, for example, 2 ml to 4 ml, and about 5 ml at the maximum.
Further, the irradiation container 51 has a bottom surface that approaches the central axis of the charged particle beam Pb as the distance from the incident side of the charged particle beam Pb increases. That is, the bottom surface of the irradiation container 51 is inclined upward from the incident side of the charged particle beam Pb toward the back.

  As shown in FIG. 4, the irradiation container 51 is designed so that the area of the cross section perpendicular to the X direction is reduced along the X direction. However, as is apparent from FIG. 4, the irradiation container 51 is different in inclination between the upper part 511a and the lower part 511b in the longitudinal section shown in FIG. In other words, the irradiation container 51 can correct (compensate) the difference in the range of the charged particle beam Pb generated by boiling the liquid target because the lower portion 511b is inclined more than the upper portion 511. For this reason, the probability of a nuclear reaction increases and the yield of the radionuclide is improved.

(Buffer part)
A plurality of buffer units 53 are arranged so that the length directions thereof are parallel to each other, and a communication path 57 that causes the plurality of buffer units 53 and the irradiation container 51 to communicate with each other and returns a target liquefied in the buffer unit 53 to the irradiation container 51. It has further.
The target device 5 of the present embodiment includes a plurality (seven) of buffer units 53. As shown in FIG. 3, the plurality of buffer units 53 are formed so as to be long in the incident direction of the charged particle beam Pb, and are arranged so that the length directions are parallel to each other.
In addition, the plurality of buffer units 53 are erected vertically and at equal intervals with respect to the tangential direction of the peripheral surface of the irradiation container 51. For this reason, the plurality of buffer units 53 are arranged radially with respect to the irradiation container 51.
According to the present embodiment, in order to increase the target cooling effect in the target device 5, the buffer unit 53 can be further elongated along the incident direction of the charged particle beam Pb to increase the surface area of the buffer unit 53. it can.
The target device 5 is fixed by being sandwiched between the frame body 21 and the frame body 23 as described above. At this time, even when the length of the buffer unit 53 is increased and the length of the target device 5 is increased, there is no problem in attaching the target device 5 to the accelerator 3. In addition, even when the length of the target device 5 is increased, there is no change in the length in the Z direction, so there is no change in the area necessary for attaching the target device 5 to the accelerator 3, and the existing target It can be attached to the accelerator 3 in the same manner as the apparatus.

As shown in FIGS. 3 and 5, the communication path 57 sequentially connects adjacent buffer parts 53 among the plurality of buffer parts 53. When the plurality of buffer parts 53 communicate with each other via the communication path 57, the pressures of the irradiation container 51 and the plurality of buffer parts 53 are equalized, and the target water level f1 is set in both the irradiation container 51 and the buffer part 53. Will be equal.
At least a part of the target vaporized in the irradiation container 51 enters the buffer section 53 from the irradiation container 51 and is cooled. At least a part of the target cooled and liquefied in any of the buffer parts 53 falls directly from the buffer part 53 to the irradiation container 51.
In addition, at least a part of the target cooled and liquefied in the buffer unit 53 enters the other buffer unit 53 via the communication path 57 connected to the tip of the buffer unit 53. And it flows in the irradiation container 51 along the buffer part 53 of the destination.
Further, the communication path 57 and the pipe line 731 are connected to provide a balance in the pressure in evaporation. As a result, the water level f1 of the target can be stabilized.

In the present embodiment, a coating film of platinum (Pt) may be formed on the peripheral wall of the buffer unit 53 as a metal catalyst. As a result, the reaction of hydrogen and oxygen generated by water radiolysis can be accelerated and water can be quickly returned, so that the increase of the target internal pressure due to the generation of non-condensable gas of hydrogen and oxygen is suppressed. In addition, it is possible to suppress products (radicals and the like) by radiolysis of water.
The formation of the platinum coating film can be realized by any method of vapor deposition, sputtering, and electrolytic plating.

  Further, in this embodiment, the communication path 57 is connected to a pipe line 711 to which He gas or water is supplied. The target remaining in the communication path 57 is pushed out by water or He gas supplied to the communication path 57 via the pipe 711 and returns to the irradiation container 51.

Furthermore, as for the buffer part 53, the surrounding wall contains the several concave curved surface 531 (refer FIG. 7) which continues.
FIG. 7 is a schematic diagram showing an enlarged top view of the buffer unit 53 shown in FIG. As shown in FIG. 7, the surfaces of the opposing wall surfaces W <b> 1 and W <b> 2 of the buffer unit 53 are concave curved surfaces 531, respectively. The concave curved surface 531 has a shape in which a part of the arc of the circle 533 is continuous. The buffer portion 53 having such wall surfaces W1 and W2 can obtain a high cooling effect because the surface area of the inner surface that contacts the vaporized target becomes larger than the plane.

In this embodiment, when forming the buffer part 53, the concave curved surface 531 is formed as follows. That is, in the present embodiment in which the buffer body 53 is formed by cutting the target body 50, a drill (not shown) is inserted from the peripheral surface of the cylindrical target body 50 in the -Y direction shown in FIG. In this way, it is formed in the X direction. The vertical holes arranged in a row overlapping each other form a buffer part 53 of a slit extending in the X direction. A portion communicating with the outside formed by inserting a plurality of vertical hole drills is filled with metal to a predetermined depth.
The diameter r of the circle 533 of the first embodiment is preferably, for example, 2 mm or more and 5 mm or less, and more preferably 3 mm. The buffer portion 53 having a diameter r of 3 mm has a track record of suitably functioning for reflux (water dripping).

(Operation)
Next, the operation of the target device described above will be described.
In the target device 5, the charged particle beam Pb passes through the foil 52 and enters the irradiation container 51. The protons of the incident charged particle beam Pb collide with hydrogen and oxygen atoms of the target. At this time, heat is generated between protons and atoms, and the liquid target boils and vaporizes. At least a part of the vaporized target enters one of the plurality of buffer units 53. The plurality of buffer parts 53 communicate with each other through the communication path 57 so that the pressure is uniform. For this reason, the vaporized target equally enters the plurality of buffer units 53. Then, the target is cooled on the inner surface of the target body 50 in the buffer unit 53 to form water droplets. At least a part of the water droplets returns to the irradiation container 51 through a path of dropping directly onto the irradiation container 51 by gravity.

  The other part of the target is cooled and liquefied in the buffer unit 53, and enters the other buffer unit 53 through the inner surface of the target body 50 on the peripheral wall of the communication path 57 communicating with the buffer unit 53. When a plurality of droplets of the target are brought together in the other buffer unit 53, the volume and weight of the droplet increase and the inner surface of the target body 50 is easily slid down. The liquid droplet sliding down the inner surface of the target body 50 returns to the irradiation container 51.

[Method for producing radiopharmaceutical]
Next, a method for producing a radiopharmaceutical using the radionuclide generated by the radionuclide production apparatus 1 described above will be described.
The method includes a recovery step of recovering the radionuclide from the radionuclide production apparatus. In the recovery step, the target is recovered from the target device 5 and ¹⁸ F is adsorbed through the target on the anion exchange resin cartridge. By eluting this with physiological saline, ¹⁸ F ions ( ¹⁸ F-NaF) can be obtained as active ingredients and radiopharmaceuticals. The method may also include a labeling step of labeling the label precursor compound using the recovered ¹⁸ F. In the labeling process, ¹⁸ F adsorbed on the anion exchange resin cartridge is eluted with a base such as potassium carbonate or tetrabutylammonium carbonate, then ¹⁸ F is dried to remove the solvent, and the labeling precursor compound and fluorination reaction are performed. Is done by letting For example, when mannose triflate is used as the labeling precursor compound, ¹⁸ F-fluorodeoxyglucose can be obtained by performing hydrolysis after the labeling step.

  The method for producing a radiopharmaceutical according to the present embodiment includes a step of generating a radionuclide with the above-described radionuclide production apparatus. Therefore, the yield of the radionuclide is increased by improving the beam amount to be irradiated by improving the cooling efficiency of the target. be able to. Therefore, it becomes possible to manufacture more radiopharmaceuticals.

The above embodiment includes the following technical idea.
(1) A radionuclide production apparatus for generating a radionuclide by irradiating a liquid target with a particle beam,
A container containing the target;
A buffer unit communicating with the container and capable of diffusing the target vaporized by the irradiation of the particle beam,
The radionuclide manufacturing apparatus, wherein the buffer unit has a shape that is longer in a length direction along an irradiation direction than a width direction orthogonal to the irradiation direction of the particle beam.
(2) A plurality of the buffer units are arranged so that the length directions thereof are in parallel, and a plurality of the buffer units and the container communicate with each other, and the target liquefied in the buffer unit is returned to the container. The radionuclide production apparatus according to (1), further including a passage.
(3) The radionuclide production apparatus according to (1) or (2), wherein the container has a cone shape in which a cross-sectional area of a plane orthogonal to the particle beam irradiation direction decreases toward the particle beam irradiation direction. .
(4) The radionuclide manufacturing apparatus according to any one of (1) to (3), wherein the container has a bottom surface that approaches a central axis of the particle beam as the particle beam is separated from the incident side.
(5) The radionuclide manufacturing apparatus according to any one of (1) to (4), wherein the peripheral wall of the buffer unit includes a coating containing a metal catalyst.
(6) The radionuclide manufacturing apparatus according to any one of (1) to (5), wherein the peripheral wall of the buffer unit includes a plurality of continuous concave curved surfaces.
(7) A target device of a radionuclide production apparatus that generates a radionuclide by irradiating a liquid target with a particle beam,
A container containing the target;
A buffer unit communicating with the container and capable of diffusing the target vaporized by the irradiation of the particle beam,
The buffer device has a shape that is longer in the length direction along the irradiation direction than in the width direction orthogonal to the irradiation direction of the particle beam.
(8) A radiopharmaceutical production method for producing a radiopharmaceutical using a radionuclide produced by the radionuclide production apparatus according to any one of (1) to (5),
A recovery step of recovering the radionuclide from the radionuclide production apparatus;
A labeling step of labeling a labeled precursor compound using the radionuclide recovered in the recovery step.
(9) A radionuclide production apparatus for generating a radionuclide by irradiating a liquid target with a particle beam,
A container containing the target;
A plurality of buffer portions communicating with the container and capable of diffusing the target vaporized by the irradiation of the particle beam;
The radionuclide manufacturing apparatus, wherein the plurality of buffer units are arranged side by side in the particle beam irradiation direction.

DESCRIPTION OF SYMBOLS 1 Radionuclide production apparatus 2 Mounting fixture 3 Accelerator 5 Target apparatus 21,23 Frame 31 Beam entrance 50 Target body 51 Irradiation container 52 Foil 57 Communication path 60 Cooling water main pipe 63 Cooling water branch pipes 71, 73 Fitting 511a Upper part 511b Lower part 711,713 Pipe line 531 Concave surface 533 Circle W1, W2 Wall surface

Claims (8)

A radionuclide production apparatus for generating a radionuclide by irradiating a liquid target with a particle beam,
A container containing the target;
A buffer unit communicating with the container and capable of diffusing the target vaporized by the irradiation of the particle beam,
The radionuclide manufacturing apparatus, wherein the buffer unit has a shape that is longer in a length direction along an irradiation direction than a width direction orthogonal to the irradiation direction of the particle beam.   A plurality of the buffer units are arranged so that the length directions thereof are parallel to each other, and a communication path for returning the targets liquefied in the buffer units to the containers by communicating a plurality of the buffer units and the containers is further provided. The radionuclide production apparatus according to claim 1.   The radionuclide manufacturing apparatus according to claim 1 or 2, wherein the container has a cone shape in which a cross-sectional area of a surface orthogonal to the irradiation direction of the particle beam decreases as the particle beam approaches the irradiation direction of the particle beam.   The radionuclide production apparatus according to any one of claims 1 to 3, wherein the container has a bottom surface that approaches a central axis of the particle beam as the particle beam is separated from the incident side.   The radionuclide manufacturing apparatus according to any one of claims 1 to 4, wherein the peripheral wall of the buffer unit includes a coating containing a metal catalyst.   The radionuclide manufacturing apparatus according to any one of claims 1 to 5, wherein the peripheral wall of the buffer unit includes a plurality of continuous concave curved surfaces. A target device of a radionuclide production apparatus that generates a radionuclide by irradiating a liquid target with a particle beam,
A container containing the target;
A buffer unit communicating with the container and capable of diffusing the target vaporized by the irradiation of the particle beam,
The buffer device has a shape that is longer in the length direction along the irradiation direction than in the width direction orthogonal to the irradiation direction of the particle beam. A radionuclide generation step of generating a radionuclide by the radionuclide production apparatus according to any one of claims 1 to 6;
A recovery step of recovering the radionuclide from the radionuclide production apparatus;
And a radiopharmaceutical production step of producing a radiopharmaceutical using the radionuclide recovered in the recovery step.

Images