JP2018013429A - Specimen inspection kit - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a specimen inspection kit capable of enhancing handleability of inspection liquid at a time of inspection.SOLUTION: A resin extraction cap 21 includes a trigger projection 22 that has a cone shape projecting from a bottom of the resin extraction cap 21 toward an opening of the resin extraction cap 21 and includes a path connecting the inside of a cylinder of the resin extraction cap 21 and the outside of the cylinder of the resin extraction cap 21, makes the trigger projection 22 burst through a seal 12 by screwing a screwing part 23 to a screwed part 13, and makes the trigger projection 22 enter an end of a tube.SELECTED DRAWING: Figure 4

Description

  The present invention relates to a specimen test kit.

  A stool collection test kit is known as an example of a sample test kit for testing a collected sample. The stool collection test kit includes, for example, a resin-containing tube that holds a test solution in which stool is dissolved in a stool dissolution buffer, and a test instrument that performs a stool test using the test solution. The resin-containing tube includes a seal that is ruptured by a trigger protrusion provided in the inspection instrument for the purpose of reducing the labor of the inspection operator, suppressing leakage of the inspection liquid, and the like. When the resin storage tube is attached to the inspection instrument, the trigger protrusion is inserted toward the seal of the resin storage tube, and the test solution penetrates from the hollow path provided in the trigger protrusion into the inspection reagent (for example, patent Reference 1).

International Publication No. 2013/141103

By the way, the seal provided in the resin-made storage tube has sufficient thickness and hardness to suppress the leakage of the inspection liquid from the resin-made storage tube. When the seal is broken, a large pressing force enough to break the seal is applied to the seal from the trigger protrusion. The pressing force applied to the seal from the trigger protrusion is, for example, a force that the inspection operator presses the seal against the trigger protrusion, and is also a force that is difficult to stop suddenly. Therefore, immediately after the seal is broken, the welded portion of the seal collides with the proximal end portion of the trigger projection, and the test liquid may scatter from the inside of the resin containing tube.
An object of the present invention is to provide a specimen test kit that can improve the handling of a test solution at the time of testing.

  A sample test kit for solving the above problems is a resin-containing tube having a cylindrical shape for storing a test solution, and includes a tube end including an opening closed by a seal, and the tube end The resin containing tube is provided with a screwed portion located on the outer peripheral surface. Further, the specimen test kit is a resin extraction cap having a bottomed cylindrical shape having an opening into which the tube end portion is inserted, and a screwed portion having a shape that can be screwed to the screwed portion. The resin extraction cap includes an inner peripheral surface that is positioned, and the screwed portion is screwed into the screwed portion to accommodate the tube end portion in the cylinder of the resin extraction cap. The resin extraction cap has a conical shape protruding from the bottom of the resin extraction cap toward the opening of the resin extraction cap, and inside the cylinder of the resin extraction cap and the resin extraction A trigger protrusion having a passage through the outside of the cap of the cap, and the threaded engagement between the threaded portion and the threaded portion causes the trigger protrusion to pierce the seal and bring the trigger protrusion into the tube end. Let it enter.

  According to the said structure, a trigger protrusion fracture | ruptures a seal | sticker by screwing with a resin-made extraction cap and a resin-made accommodation tube. At this time, the speed at which the trigger protrusion that has broken the seal is advanced into the tube end corresponds to the speed at which the screwed portion and the screwed portion are screwed together. As a result, if the screwing of the screwed part and the screwed part proceeds, the trigger protrusion enters the tube end, and if the screwing of the screwed part and the screwed part stops, The trigger protrusion stops entering the tube end. Since the trigger protrusion enters the tube end portion by screwing, the scattering of the inspection liquid due to the collision between the welded portion of the seal and the proximal end portion of the trigger protrusion is suppressed. As a result, it becomes possible to improve the handleability of the test liquid during the test.

  In the specimen test kit, the inner peripheral surface of the tube end portion may be configured such that the seal that has been broken by the trigger protrusion is connected to the outer peripheral surface of the trigger protrusion in a state where the screwed portion and the screwed portion are screwed together. You may have a magnitude | size pressed on.

  According to the specimen test kit, the seal broken by the trigger protrusion is pressed against the outer peripheral surface of the trigger protrusion by the inner peripheral surface of the tube end. Therefore, even after the seal is broken, in the state where the screwed portion and the screwed portion are screwed together, the inspection liquid leaks from the gap between the resin containing tube and the resin extraction cap. It can also be suppressed.

  In the specimen test kit, the tube end portion is a tube distal end portion, and the resin-made storage tube has flexibility including a tube base end portion that is a cylindrical end portion opposite to the tube distal end portion. This is a molded resin product. And the said tube front-end | tip part is provided with the seal rib over the whole circumferential direction of the said outer peripheral surface at the said tube base end side rather than the said to-be-threaded part, and the said seal rib has the said to-be-threaded part and the said to-be-threaded part In a state where the two are screwed together, the resin extraction cap may have a size to be pressed against the inner peripheral surface.

  According to the specimen test kit, the seal rib located on the outer peripheral surface of the tube end is pressed against the inner peripheral surface of the resin extraction cap. Therefore, even after the seal is broken, in the state where the screwed portion and the screwed portion are screwed together, the inspection liquid leaks from the gap between the resin containing tube and the resin extraction cap. It can also be suppressed.

  In the specimen test kit, the tube end portion is a tube distal end portion, and the resin-made storage tube has flexibility including a tube base end portion that is a cylindrical end portion opposite to the tube distal end portion. This is a molded resin product. And the outer peripheral surface of the said resin accommodation tube may be equipped with the reinforcement rib which protrudes on the outer side of the radial direction in the said resin accommodation tube in the said tube base end side rather than the said to-be-threaded part.

  According to the specimen test kit, the reinforcing rib positioned on the tube base end side with respect to the screwed portion increases the rigidity of the resin containing tube. Therefore, it is possible to prevent the resin housing tube from being twisted unnecessarily when the resin housing tube and the resin extraction cap are screwed together.

  In the specimen test kit, the resin extraction cap may include a dripping nozzle that communicates with a passage provided in the trigger protrusion on an outer bottom surface of the resin extraction cap.

According to the specimen test kit, the test liquid stored in the resin storage tube can be dropped by the dropping nozzle. Therefore, it is possible to improve workability in the test using the sample test kit.
In the specimen test kit, the seal may include a resin seal.
According to the specimen test kit, the seal is more easily elastically deformed when the trigger protrusion breaks through the seal as compared with the configuration in which the seal is made of only the metal seal. As a result, it becomes possible to suppress the leakage of the inspection liquid from the gap between the seal and the trigger protrusion.

The perspective view which shows the disassembled perspective structure in one Embodiment of a stool collection inspection kit. The perspective view which shows the disassembled perspective structure in one Embodiment of a stool collection inspection kit. The perspective view which shows the perspective structure of resin extraction caps. The operation | movement figure of a stool collection test kit which shows the attachment start time of the resin extraction cap. The operation | movement figure of a stool collection inspection kit which shows the time of completion | finish of attachment of resin extraction caps. The perspective view for demonstrating the usage type in the sample test kit of a modification.

With reference to FIGS. 1 to 5, an example of a stool collection test kit will be described as an embodiment of a sample test kit.
As shown in FIG. 1, the stool collection inspection kit includes a resin housing tube 11 and a resin extraction cap 21.

  The resin storage tube 11 has a cylindrical shape for storing the test solution. The resin-made accommodation tube 11 includes a tube distal end portion 11E1 and a tube base end portion 11E2 that is an end portion opposite to the tube distal end portion 11E1. The tube tip portion 11E1 is an example of a tube end portion. The test solution stored in the resin storage tube 11 is a liquid in which stool is dissolved in a stool dissolution buffer. The stool dissolution buffer contains a buffer and may be any liquid suitable for stool examination, and may contain additives such as stabilizers, deodorants, preservatives, and dyes.

  The tube tip portion 11E1 of the resin containing tube 11 includes an opening having a circular hole shape. The end surface of the tube distal end portion 11E1 is a flat surface, and the opening at the tube distal end portion 11E1 is closed by the seal 12. The material constituting the seal 12 is any one of metals such as aluminum, resins such as polyethylene and polypropylene, and combinations thereof. The blockage by the seal 12 may be due to thermal welding between the tube tip portion 11E1 and the seal 12, or may be due to an adhesive.

  The outer peripheral surface of the tube distal end portion 11E1 of the resin containing tube 11 includes a screwed portion 13 that functions as a male screw. The screwed portion 13 is a spiral protrusion extending in the extending direction of the resin containing tube 11. The threaded portion 13 may be a ridge extending in the entire circumferential direction of the tube tip portion 11E1, or may be a ridge formed on a part of the circumferential direction.

  The tube base end portion 11E2 of the resin containing tube 11 is provided with an opening having a circular hole shape, and is configured such that the sample collecting rod 11K can be screwed. The sample collection rod 11K is embodied, for example, as a stool collection rod for collecting stool. The tip of the sample collection rod 11K has a groove shape so that feces are easily attached. When the sample collection rod 11K collects stool, first, the sample collection rod 11K is removed from the resin containing tube 11. Next, the tip of the sample collection rod 11K is stabbed into the stool, and the groove shape of the sample collection rod 11K scrapes the stool.

  In the resin containing tube 11, the outer peripheral surface of the tube distal end portion 11 </ b> E <b> 1 includes a seal rib 14. The seal rib 14 is located on the tube base end portion 11E2 side with respect to the screwed portion 13. The seal rib 14 protrudes outward in the radial direction on the outer peripheral surface of the tube distal end portion 11E1. The seal rib 14 has an annular shape over the entire circumferential direction on the outer peripheral surface of the tube distal end portion 11E1.

  Further, the outer peripheral surface of the tube distal end portion 11E1 includes a reinforcing rib 15. The reinforcing rib 15 is positioned closer to the tube base end portion 11E2 than the seal rib 14 is. The reinforcing rib 15 protrudes outward in the radial direction from the seal rib 14 on the outer peripheral surface of the tube distal end portion 11E1. The reinforcing rib 15 is thicker than the seal rib 14 on the outer peripheral surface of the tube distal end portion 11E1, and has a triple annular shape over the entire circumferential direction. For example, as shown in FIG. 1, the outer shape of the reinforcing rib 15 is a square frame shape surrounding the tube tip portion 11 </ b> E <b> 1 when viewed from the extending direction of the resin containing tube 11.

  The material constituting the resin housing tube 11 is a flexible resin having flexibility such as low density polyethylene, for example. If the material constituting the resin-made accommodation tube 11 is a flexible resin, the resin-made accommodation tube 11 is crushed so that the specimen contained in the resin-made accommodation tube 11 can be squeezed. Another example of the material constituting the resin housing tube 11 is a resin such as polypropylene or polyethylene.

  The resin extraction cap 21 has a bottomed cylindrical shape having an opening into which the tube tip portion 11E1 of the resin containing tube 11 is inserted. The outer bottom surface 21 </ b> B of the resin extraction cap 21 includes a dripping nozzle 24. The resin extraction cap 21 includes a cap main body 21M having a bottomed cylindrical shape, and the dropping nozzle 24 is welded or fitted to the outer bottom surface of the cap main body 21M. The dropping nozzle 24 drops the inspection liquid stored in the resin storage tube 11 as a droplet having a predetermined size.

  As shown in FIG. 2, the inner peripheral surface 21 </ b> S of the resin extraction cap 21 includes a screw portion 23. The screw part 23 has a spiral shape extending along the central axis of the cap body part 21M. The screwing portion 23 has a shape that can be screwed with the screwed portion 13 of the resin containing tube 11. Then, when the screwing portion 23 is screwed with the screwed portion 13, the tube tip portion 11 </ b> E <b> 1 of the resin containing tube 11 is accommodated in the tube of the resin extraction cap 21.

  As shown in FIG. 3, the bottom of the cap main body 21 </ b> M includes a trigger protrusion 22. The trigger protrusion 22 has a cone shape protruding from the bottom of the resin extraction cap 21 toward the opening of the resin extraction cap 21.

  The trigger protrusion 22 includes a protrusion base 22E having a cylindrical shape having an outer diameter D1. The outer diameter D1 of the protrusion base 22E is substantially equal to the inner diameter of the tube tip portion 11E1 of the resin containing tube 11. The inner bottom surface of the resin extraction cap 21 is a flat surface, and the protrusion base 22E is integral with the inner bottom surface of the resin extraction cap 21. The filter 25 is located inside the protrusion base 22E. The filter 25 has a function of filtering a solid content that hinders the inspection of the inspection liquid, and is inactive with respect to the inspection liquid. The filter 25 is, for example, a porous material such as a resin sintered filter or filter paper, or a fibrous material such as absorbent cotton or glass wool.

  The trigger protrusion 22 includes a conical portion 22T that protrudes from the protrusion base 22E toward the opening of the resin extraction cap 21. The protrusion base 22E and the conical part 22T are integral. The conical portion 22T includes a plurality of through holes 22H. Each through hole 22H penetrates the conical portion 22T in the direction in which the trigger protrusion 22 protrudes. Each through-hole 22H functions as a passage through the inside of the cylinder of the protrusion base 22E and the outside of the cylinder of the resin extraction cap 21 and the outside of the cylinder of the resin extraction cap 21. Note that the inside of the conical portion 22T includes a rib for increasing the rigidity at the tip of the trigger protrusion 22.

  The inner peripheral surface of the cap main body portion 21M is a cylindrical surface having an inner diameter D2. The cap body 21M has an inner diameter D2 that is larger than the outer diameter of the tube tip 11E1 of the resin containing tube 11 and slightly smaller than the outer diameter of the seal rib 14. The distance that the inner surface of the resin extraction cap 21 has in the direction in which the trigger protrusion 22 protrudes, that is, the direction along the central axis of the cap main body 21M, is the insertion length H. The insertion length H is slightly longer than the distance between the seal 12 and the seal rib 14 in the extending direction of the resin containing tube 11.

Next, the operation of the stool collection test kit will be described.
First, the sample collection rod 11K is removed from the resin containing tube 11 containing the test solution, and the tip of the sample collection rod 11K is pierced by a stool or the like as an example of the sample. Next, the specimen collection rod 11K after the specimen is collected is attached to the resin containing tube 11 again. Subsequently, as shown in FIG. 4, the tube distal end portion 11 </ b> E <b> 1 of the resin containing tube 11 is inserted into the resin extraction cap 21 from the opening of the resin extraction cap 21. Next, the resin housing tube 11 and the resin extraction cap 21 are relatively rotated, so that the screwed portion 13 of the resin housing tube 11 and the screwed portion 23 of the resin extraction cap 21 are screwed together. Is advanced. As a result, the conical portion 22T of the trigger protrusion 22 breaks the seal 12, and the trigger protrusion 22 enters the inside of the tube tip portion 11E1.

  At this time, the rotation direction of the resin extraction cap 21 is fixed to the circumferential direction of the resin storage tube 11. The direction in which the trigger protrusion 22 advances is fixed in the extending direction of the resin housing tube 11. Accordingly, the direction in which the force for causing the trigger projection 22 to break the seal 12 acts is the direction in which the trigger projection 22 advances with respect to the seal 12, that is, the extending direction of the screwed portion 23 or the screwed portion 13. Fixed. Therefore, the force for the trigger projection 22 to break the seal 12 acts in a stable direction without changing the direction of application according to the technique of the inspection operator. Moreover, it is possible to stabilize the direction in which the force for breaking the seal 12 acts, and to apply a torsional force to the breaking of the seal 12, so that even if the thickness of the seal 12 itself is increased, It is also possible to stabilize the progress of breakage of the seal 12. Therefore, it is possible to increase the effect of suppressing the leakage of the test solution by increasing the thickness of the seal 12 itself.

  Further, the speed at which the trigger protrusion 22 that breaks the seal 12 advances into the tube tip portion 11E1 corresponds to the speed at which the screwing portion 23 and the screwed portion 13 are screwed together. As a result, when the screwing of the screwed portion 23 and the screwed portion 13 proceeds, the trigger protrusion 22 advances into the tube tip portion 11E1, and the screwed portion 23 and the screwed portion 13 are screwed together. If the advancement stops, the entry of the trigger projection 22 into the tube tip 11E1 stops. Therefore, scattering of the inspection liquid due to a collision between the end surface of the tube distal end portion 11E1 and the inner bottom surface of the cap main body portion 21M can be suppressed. As a result, it becomes possible to improve the handleability of the test liquid during the test.

  In addition, the outer peripheral surface of the resin housing tube 11 is provided with a reinforcing rib 15 protruding outward in the radial direction of the resin housing tube 11 on the tube base end portion 11E2 side with respect to the screwed portion 13. Such reinforcing ribs 15 increase the rigidity of the resin containing tube 11. Therefore, it is possible to prevent the resin housing tube 11 from being twisted unnecessarily when the resin housing tube 11 and the resin extraction cap 21 are screwed together.

  As shown in FIG. 5, the end face of the tube distal end portion 11 </ b> E <b> 1 of the resin containing tube 11 and the inner bottom face of the resin extraction cap 21 sandwich the broken seal 12. Thereby, the screwing of the screwed portion 23 and the screwed portion 13 is completed. The test liquid leaks from the gap between the resin housing tube 11 and the resin extraction cap 21 when the end surface of the tube tip 11E1 of the resin housing tube 11 and the inner bottom surface of the resin extraction cap 21 are in close contact with each other. Is suppressed.

  At this time, since the inner diameter of the tube distal end portion 11E1 of the resin containing tube 11 is substantially equal to the outer diameter D1 of the protrusion base portion 22E, the seal 12 broken by the trigger protrusion 22 is pressed against the outer peripheral surface of the protrusion base portion 22E. Further, since the outer diameter of the seal rib 14 of the resin containing tube 11 is slightly larger than the inner diameter D2 of the resin extraction cap 21, the outer peripheral surface of the seal rib 14 is pressed against the inner peripheral surface of the resin extraction cap 21. As a result, even after the seal 12 is broken, in the state where the screwed portion 13 and the screwed portion 23 are completely screwed together, the gap between the resin containing tube 11 and the resin extracting cap 21 is eliminated. It is possible to prevent the inspection liquid from leaking out.

  For example, when the resin housing tube 11 is squeezed in a state where the threaded portion 13 and the screwed portion 23 are screwed together, the test liquid located inside the resin housing tube 11 causes the filter 25 to pass through. It passes and drops from the dropping nozzle 24.

As mentioned above, according to the said embodiment, the effect enumerated below is acquired.
(1) When the progress of the screwing between the screwed portion 23 and the screwed portion 13 stops, the trigger protrusion 22 stops entering the tube tip portion 11E1. Therefore, scattering of the inspection liquid due to a collision between the end surface of the tube distal end portion 11E1 and the inner bottom surface of the resin extraction cap 21 can be suppressed.

(2) In a state where the screwed portion 23 and the screwed portion 13 are screwed together, it is possible to suppress leakage of the inspection liquid from the gap between the resin containing tube 11 and the resin extraction cap 21. .
(3) When the resin housing tube 11 and the resin extraction cap 21 are screwed together, the resin housing tube 11 is prevented from being twisted unnecessarily.

(4) Since the inspection liquid stored in the resin storage tube 11 can be dropped by the dropping nozzle 24, the workability in the inspection using the stool collection inspection kit can be improved.
(5) Since the seal 12 includes a resin seal, the seal 12 is easily elastically deformed when the trigger projection 22 breaks through the seal 12. As a result, it is possible to prevent the reagent from leaking from the gap between the seal 12 and the trigger protrusion 22.
(6) When the inspection is completed, the sample collection rod 11K, the resin containing tube 11 and the resin extraction cap 21 are combined. Therefore, it is possible to discard the specimen test kit after the test is completed as a combination of these. As a result, it is possible to improve the discardability of the specimen test kit and the safety in handling the specimen test kit.

In addition, the said embodiment can also be changed and implemented as follows.
The dropping nozzle 24 is omitted from the resin extraction cap 21, and the resin extraction cap 21 has a separate passage for communicating the filter 25 and the test reagent, for example. Even in this configuration, it is possible to obtain the effects according to the above (1) to (3).

The reinforcing ribs 15 are omitted from the resin housing tube 11, and the resin housing tube 11 is thicker at the tube base end portion 11 E 2 side than the tube distal end portion 11 E 1 or the screwed portion 13, for example. Configured. Even in this configuration, it is possible to obtain the effect according to the above (3).
The resin extraction cap 21 can be embodied as a structure in which the filter 25 is omitted.

  The sample collection rod is not limited to the stool collection rod, but is changed to a member provided with, for example, cotton for collecting a sample at the tip of the rod member, and is used for examining the presence of viruses, bacteria, and the like. At this time, the specimen test kit is embodied as a kit for testing specimens such as viruses and bacteria.

  For example, as shown in FIG. 6, one end of the resin containing tube 11 provided in the sample test kit includes an insertion port 11T, and the insertion port 11T is closed by a proximal end seal 12T. The material constituting the proximal seal 12T is any one of a metal such as aluminum, a resin such as polyethylene and polypropylene, and a combination thereof, like the seal 12. The inside of the resin containing tube 11 is closed by the seal 12 and the base end seal 12T and contains a test solution. Absorbent cotton or the like is wound around the tip 11M of the sample collecting rod 11K, and is used for collecting a sample to be inspected such as a nasal wipe. When a test using the specimen test kit is performed, first, the proximal end seal 12T is peeled off from the insertion port 11T of the resin containing tube 11, and the insertion port 11T is opened. Next, the sample collection rod 11K that collects the sample is inserted into the resin-made storage tube 11 from the tip 11M of the sample collection rod 11K, and screwed into the insertion port 11T of the resin-made storage tube 11. As described above, the inspection liquid can be dropped from the dropping nozzle 24 by attaching the resin extraction cap 21 to the resin containing tube 11. Since such a sample test kit stores the test solution and the sample collection rod 11K separately, it is not necessary to immerse the sample collection rod 11K before the test in the test solution. Therefore, it is suitable for an examination in which the specimen collecting rod 11K is inserted into the living body when the specimen is collected.

H Insertion length D1 Outer diameter D2 Inner diameter 11 Resin housing tube 11E1 Tube tip 11E2 Tube base end 11K Sample collection rod 11M Tip 11T Insert 12 Seal 12T Base seal 13 Screwed portion 14 Seal rib 15 Reinforcement rib 21 Resin Made Extraction Cap 21B Outer Bottom 21M Cap Body 21S Inner Perimeter 22 Trigger Projection 22E Projection Base 22H Through Hole 22T Conical Part 23 Threaded Part 24 Dropping Nozzle 25 Filter

Claims (6)

A resin storage tube having a cylindrical shape for storing a test solution, comprising a tube end including an opening closed by a seal, and a screwed portion positioned on an outer peripheral surface of the tube end. The resin containing tube;
A resin extraction cap having a bottomed cylindrical shape having an opening into which the tube end portion is inserted, and comprising an inner peripheral surface on which a screwed portion having a shape that can be screwed to the screwed portion is located. The resin extraction cap that accommodates the tube end portion in the cylinder of the resin extraction cap by the screwing portion being screwed with the screwed portion;
The resin extraction cap has a conical shape protruding from the bottom of the resin extraction cap toward the opening of the resin extraction cap, and the inside of the resin extraction cap and the resin extraction cap A trigger projection having a passage through the outside of the cylinder is provided, and the trigger projection is made to penetrate into the tube end portion by causing the trigger projection to pierce the seal by screwing between the screwed portion and the screwed portion. Specimen test kit. The inner peripheral surface of the tube end portion has a size for pressing the seal broken by the trigger protrusion against the outer peripheral surface of the trigger protrusion in a state where the screwed portion and the screwed portion are screwed together. The specimen test kit according to claim 1. The tube end is a tube tip,
The resin-containing tube is a flexible resin molded body having a tube base end that is a tube end opposite to the tube tip,
The tube distal end portion is provided with a seal rib over the entire circumferential direction of the outer peripheral surface on the tube base end side of the screwed portion,
The specimen test kit according to claim 1, wherein the seal rib has a size to be pressed against an inner peripheral surface of the resin extraction cap in a state where the screwed portion and the screwed portion are screwed together. The tube end is a tube tip,
The resin-containing tube is a flexible resin molded body having a tube base end that is a tube end opposite to the tube tip,
4. The outer peripheral surface of the resin housing tube includes a reinforcing rib projecting outward in the radial direction of the resin housing tube on the tube base end side of the screwed portion. The specimen test kit according to Item. The specimen test kit according to any one of claims 1 to 4, wherein the resin extraction cap includes a dripping nozzle that communicates with a passage provided in the trigger protrusion on an outer bottom surface of the resin extraction cap. The specimen test kit according to any one of claims 1 to 5, wherein the seal includes a resin seal.