JP2017538927A5 - - Google Patents

Info

Publication number

JP2017538927A5

JP2017538927A5 JP2017526906A JP2017526906A JP2017538927A5 JP 2017538927 A5 JP2017538927 A5 JP 2017538927A5 JP 2017526906 A JP2017526906 A JP 2017526906A JP 2017526906 A JP2017526906 A JP 2017526906A JP 2017538927 A5 JP2017538927 A5 JP 2017538927A5

Authority

JP

Japan

Prior art keywords

subject

biomarker

pick disease

group

level

Prior art date

2015-11-19

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Ceased

Links

• Espacenet
• Global Dossier
• Discuss

• 239000000090 biomarker Substances 0.000 claims 35
• 201000011240 Frontotemporal dementia Diseases 0.000 claims 21
• 208000000609 Pick Disease of the Brain Diseases 0.000 claims 21
• 208000024571 Pick disease Diseases 0.000 claims 21
• 150000001875 compounds Chemical class 0.000 claims 17
• 210000004369 blood Anatomy 0.000 claims 15
• 239000008280 blood Substances 0.000 claims 15
• 238000000034 method Methods 0.000 claims 13
• 208000014060 Niemann-Pick disease Diseases 0.000 claims 9
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
• 125000000896 monocarboxylic acid group Chemical group 0.000 claims 8
• 238000002560 therapeutic procedure Methods 0.000 claims 8
• 239000010836 blood and blood product Substances 0.000 claims 6
• 229940125691 blood product Drugs 0.000 claims 6
• OKTWQKXBJUBAKS-WQADZSDSSA-N 2-[[(e,2r,3s)-2-amino-3-hydroxyoctadec-4-enoxy]-hydroxyphosphoryl]oxyethyl-trimethylazanium;chloride Chemical compound [Cl-].CCCCCCCCCCCCC\C=C\[C@H](O)[C@H](N)COP(O)(=O)OCC[N+](C)(C)C OKTWQKXBJUBAKS-WQADZSDSSA-N 0.000 claims 4
• 210000001175 cerebrospinal fluid Anatomy 0.000 claims 3
• 238000004949 mass spectrometry Methods 0.000 claims 3
• 210000003296 saliva Anatomy 0.000 claims 3
• 210000002966 serum Anatomy 0.000 claims 3
• 210000001519 tissue Anatomy 0.000 claims 3
• 210000002700 urine Anatomy 0.000 claims 3
• 208000035374 Chronic visceral acid sphingomyelinase deficiency Diseases 0.000 claims 2
• 208000035343 Infantile neurovisceral acid sphingomyelinase deficiency Diseases 0.000 claims 2
• 108010006519 Molecular Chaperones Proteins 0.000 claims 2
• 201000000794 Niemann-Pick disease type A Diseases 0.000 claims 2
• 201000000791 Niemann-Pick disease type B Diseases 0.000 claims 2
• 208000010577 Niemann-Pick disease type C Diseases 0.000 claims 2
• 208000007824 Type A Niemann-Pick Disease Diseases 0.000 claims 2
• 208000008291 Type B Niemann-Pick Disease Diseases 0.000 claims 2
• 208000007930 Type C Niemann-Pick Disease Diseases 0.000 claims 2
• 239000003153 chemical reaction reagent Substances 0.000 claims 2
• 238000002641 enzyme replacement therapy Methods 0.000 claims 2
• 238000001415 gene therapy Methods 0.000 claims 2
• 210000004880 lymph fluid Anatomy 0.000 claims 2
• 239000007787 solid Substances 0.000 claims 2
• 238000011476 stem cell transplantation Methods 0.000 claims 2
• 239000000758 substrate Substances 0.000 claims 2
• 230000001629 suppression Effects 0.000 claims 2
• 238000000018 DNA microarray Methods 0.000 claims 1
• 238000001514 detection method Methods 0.000 claims 1
• 238000003745 diagnosis Methods 0.000 claims 1
• 210000003608 fece Anatomy 0.000 claims 1
• 238000003018 immunoassay Methods 0.000 claims 1
• 230000003993 interaction Effects 0.000 claims 1
• 210000002751 lymph Anatomy 0.000 claims 1
• 238000000816 matrix-assisted laser desorption--ionisation Methods 0.000 claims 1
• 108020004707 nucleic acids Proteins 0.000 claims 1
• 150000007523 nucleic acids Chemical class 0.000 claims 1
• 102000039446 nucleic acids Human genes 0.000 claims 1
• 238000000672 surface-enhanced laser desorption--ionisation Methods 0.000 claims 1
• WDHFPFPKCLQJOH-BMRADRMJSA-N C[N](C)(C)CCOP(O)(OCC(C(/C=C/CCCCCCCCCCCCCC(O)=O)O)N)=O Chemical compound C[N](C)(C)CCOP(O)(OCC(C(/C=C/CCCCCCCCCCCCCC(O)=O)O)N)=O WDHFPFPKCLQJOH-BMRADRMJSA-N 0.000 description 1