JP2017523003A - Temperature controlled drug storage device - Google Patents

Abstract

In some embodiments, the pharmaceutical storage container comprises a drying unit, an opening, a heating element, a controller, a cooling unit, a compression system, a steam line, a steam control unit, a pharmaceutical storage unit, The drying unit includes an outer wall that forms an impermeable barrier around an inner drying region, the compression system includes at least one coil unit for an evaporator, and the controller includes: Operatively attached to the heating element, the compressor is operably attached to the controller, the steam line is attached to the drying unit at a first end, and the steam The pipe line is attached to the evaporator coil unit at a first end, and there is an air-impermeable passage between the drying unit and the cooling unit. A control unit is attached to the vapor line and is operably attached to the controller, and the medicine storage unit is around a medicine storage area with a temperature sensor operably attached to the controller. It has an outer wall that surrounds.

Description

Detailed Description of the Invention

  The subject matter of the prior application is hereby incorporated by reference unless there is a conflict.

(Overview)
In one aspect, the pharmaceutical storage container is not limited to this aspect, but includes a drying unit, a heating element, a controller, a cooling unit, a compression system, a steam line, and a steam control unit. A pharmaceutical storage unit, wherein the drying unit comprises one or more outer walls, and the one or more outer walls of the drying unit are sealed together so as to surround an inner drying area An impervious barrier is formed, the one or more outer walls of the drying unit are provided with openings, the heating element is disposed in the internal drying region, and the controller The cooling unit includes one or more outer walls, and the one or more outer walls of the cooling unit are sealed together so that they surround the inner evaporation region. Bad Forming a gas- and liquid-impervious barrier, wherein the one or more outer walls of the cooling unit are provided with openings, and the compression system is arranged at least in the internal dry evaporation zone of the cooling unit One evaporator coil unit, the compression system is operatively connected to the controller, the steam line has a first end and a second end, the steam line being Attached to an outer surface of the one or more outer walls surrounding the opening of the drying unit at the first end, and the steam line surrounds the opening of the evaporative cooling unit at the second end. Attached to the outer surface of one or more outer walls, the steam line between the inner drying area of the drying unit and the inner evaporation area of the cooling unit; The steam control unit is attached to the steam line, the steam control unit is operably attached to the controller, and the medicine storage unit is a medicine storage area. One or more outer walls, and the pharmaceutical storage area includes at least one temperature sensor operably attached to the controller.

  In one aspect, the pharmaceutical storage container is not limited to this aspect, but includes a drying unit, a heating element, a controller, a cooling unit, a compression system, a refrigeration unit, a steam line, A vapor control unit; and a medicine storage unit, wherein the drying unit includes one or more outer walls, and the one or more outer walls of the drying unit are integrally sealed, thereby allowing internal drying. An impermeable barrier is formed around a region, the one or more outer walls of the drying unit are provided with openings, and the heating element is disposed in the inner drying region, the control unit A vessel is attached to the heating element, the cooling unit includes one or more outer walls, and the one or more outer walls of the cooling unit are integrally sealed to provide an internal evaporation area. An impermeable and liquid-impervious barrier is formed around the cooling unit, the one or more outer walls of the cooling unit are provided with openings, and the compression system is disposed in the internal evaporation region of the cooling unit. At least one evaporator coil unit disposed on the compressor system, wherein the compression system is operatively connected to the controller, and the refrigeration unit comprises one or more walls, A refrigeration unit is in thermal contact with the at least one evaporator coil unit disposed within the internal evaporation region of the cooling unit, the steam line having a first end and a second end; The steam line is attached to the outer surface of the one or more outer walls surrounding the opening of the drying unit at the first end, and the steam line is connected to the cooling end at the second end. Attached to the outer surface of the one or more outer walls surrounding the opening of the knit, the steam line between the internal drying area of the drying unit and the internal evaporation area of the cooling unit. Forming a gas permeable internal passage, the steam control unit is attached to the steam line, the steam control unit is operably attached to the controller, and the medicine storage unit is One or more outer walls surrounding the drug storage area, the drug storage area including at least one temperature sensor operably attached to the controller.

  In one aspect, the pharmaceutical storage container is not limited to this aspect, but includes a drying unit, a heating element, a controller, a cooling unit, a compression system, a steam line, and a steam control unit. A thermal control unit; and a pharmaceutical storage unit, wherein the drying unit includes one or more outer walls, and the one or more outer walls of the drying unit are integrally sealed, thereby allowing internal drying. An impermeable barrier is formed around a region, the one or more outer walls of the drying unit are provided with openings, and the heating element is disposed in the inner drying region, the control unit A vessel is attached to the heating element, the cooling unit includes one or more outer walls, and the one or more outer walls of the cooling unit are integrally sealed to provide an internal evaporation area. An impervious and liquid-impervious barrier is formed around the cooling unit, the one or more outer walls of the cooling unit are provided with openings, and the compression system is disposed within the internal evaporation region of the cooling unit. At least one evaporator coil unit, wherein the compression system is operably attached to the controller, and the steam line has a first end and a second end. The steam line is attached to an outer surface of the one or more outer walls surrounding the opening of the drying unit at the second end, and the steam line is connected to the cooling unit at the first end. Attached to an external surface of the one or more outer walls surrounding the opening of the steam line, the steam line between the internal drying area of the drying unit and the internal evaporation area of the cooling unit An impermeable inner passage is formed, the steam control unit is attached to the steam line, the steam control unit is operatively attached to the controller, and the heat control unit Is attached to the steam line, the thermal control unit is operably attached to the controller, and the pharmaceutical storage unit comprises one or more outer walls surrounding a pharmaceutical storage area The pharmaceutical storage area comprises at least one temperature sensor operably connected to the controller.

  In addition to the foregoing, other aspects are described in the claims, in the drawings, and in the text forming a part of the disclosure herein. The above summary is illustrative only and is not intended to be in any sense limiting. In addition to the aspects, embodiments, and features illustrated above, other aspects, embodiments, and features are manifested by reference to the drawings and the following detailed description.

(Detailed explanation)
In the following detailed description, reference is made to the accompanying drawings, which are also part of this document. In the drawings, similar components are generally the same unless otherwise specified. Illustrative embodiments are described in the detailed description, drawings, and claims, but the invention is not limited thereto.

  Other embodiments are possible and other modifications are possible without departing from the intent or purpose of the subject matter presented herein.

  The same reference symbols used in different drawings denote similar or identical items unless otherwise specified.

  The pharmaceutical storage container (container) described herein comprises a vapor controlled cooling system integrated with a compressor by a cooling system. The pharmaceutical storage container is equipped with an evaporative cooling system, which evaporates and cools the internal storage area of the container over a predetermined temperature range for a period of time, such as days or weeks, even when there is no power to operate the compression system. It is equipped with an evaporative cooling system that is calibrated and controlled to maintain within. During use of the drug storage container, the temperature in the drug storage container is maintained within a certain temperature range, for example, over a period of several weeks or months. The pharmaceutical storage container is equipped with a compressor based on cooling of the liquid used in the evaporative cooling system as an accessory system in conjunction with the evaporative cooling system. In certain embodiments, the drug storage container is calibrated such that the interior of the drug storage area of the container is maintained within a predetermined temperature range. In some embodiments, the drug storage container is calibrated to maintain the interior of the drug storage area of the container at a predetermined temperature range of 0 ° C to 10 ° C. In certain embodiments, the drug storage container is calibrated to maintain the interior of the drug storage area of the container at a predetermined temperature range of 2 ° C to 8 ° C. The medicine storage container is suitable for use for storing medicines such as vaccines, and the storage temperature at this time must be kept within a temperature range of 0 ° C. or higher in order to prevent the stored substance from freezing. However, in order to maintain the bioactivity of the drug, it must be kept below a critical value, such as 10 ° C. or less. The drug storage container, as described herein, requires minimal power to control the rate of operation and evaporative cooling, for example, this minimum power is required in a typical refrigeration unit. It is lower than the motive power. A pharmaceutical storage container can be recharged, repaired, or restored, allowing the storage container to be reused over a period of time.

  Various embodiments are configured for use in a variety of environments, including the desired temperature fluctuations. In some embodiments, the pharmaceutical storage container is designed to be used in an environment where power supply is intermittent or uncertain at least for some period of time. In one example, a drug storage container is designed to be used when powered on average for only 2 hours per day, where the power supply may be on days when higher power is available. There are days when there is no power supply. For example, a drug storage container is designed to be used when power is supplied for only 4 hours on average per day, where the power supply may be higher on some days. There are days when there is no power supply. In one example, a drug storage container is designed to be used if it is powered on average only 6 hours per day, where the power supply can be on days when higher power can be supplied. If there are days, there is no power supply. Certain embodiments of the drug storage container do not require an external power supply that can be operated weekly to maintain the internal temperature of the drug storage area within a set temperature range. In certain embodiments, the drug storage container is passive and does not require an external power source. In some embodiments, the drug storage container is manual and does not require an external power source (eg, power is supplied by a manual crank or similar manual mechanism).

  In certain embodiments, the drug storage container is configured to maintain a drug storage area of the container in a range between 0 ° C. and 10 ° C. for at least 7 days without power. Yes. During this time, the ambient temperature outside the drug storage container is continuously around 43 ° C. without power supply. In certain embodiments, the drug storage container is configured to maintain the drug storage area of the container for at least 7 days with a temperature range between 0 ° C. and 10 ° C., during which time the drug storage container is external to the drug storage container. The ambient temperature varies within a range of approximately 30 ° C. to 43 ° C., for example, in a day / night cycle. In certain embodiments, the pharmaceutical storage container is configured to maintain the temperature range of the container in the range between 0 ° C. and 10 ° C. for at least 14 days without power supply. During this time, the ambient temperature outside the drug storage container is maintained at about 43 ° C. In certain embodiments, the drug storage container is configured to maintain the drug storage area of the container at a temperature range between 0 ° C. and 10 ° C. for at least 14 days without power. During this time, the ambient temperature outside the drug storage container fluctuates within a range between approximately 30 ° C. and 43 ° C., for example, in a day / night cycle. In one embodiment, the drug storage container is always between 0 ° C. and 10 ° C., with the drug storage area of the container being able to be powered for less than 2 hours per day for several months or years. It is configured to maintain within a temperature range, during which the ambient temperature outside the drug storage container is maintained at about 43 ° C. In certain embodiments, the drug storage container is configured to maintain the drug storage area of the container at a temperature range between 0 ° C. and 10 ° C. for at least 14 days without power. During this time, the ambient temperature outside the drug storage container fluctuates within a range of approximately 30 ° C. to 43 ° C., for example, in a day / night cycle. In certain embodiments, the drug storage container has a temperature between 0 ° C. and 10 ° C., with the drug storage area of the container being able to be powered for less than 2 hours per day for months or years. Configured to stay within range. During this time, the ambient temperature outside the drug storage container varies within a range between approximately 30 ° C. and 43 ° C., for example, in a day / night cycle.

  In general, a pharmaceutical storage container is configured so that its size, weight, and shape can be used in a clinic or a health institution, and is optimal as a storage container for pharmaceuticals such as vaccines and thermoactive drugs. . Pharmaceutical storage containers as described herein are movable. In certain embodiments, the pharmaceutical storage container can be carried and carried by a person for a predetermined period, such as a day. In some embodiments, the drug storage container is mobile, but not necessarily configured to be easily portable by one person. The medical storage container according to an embodiment has a weight in the range of between about 8 Kg and about 15 Kg, as an example. As an example, in one embodiment, the pharmaceutical storage container has a weight of about 8 Kg. As an example, in one embodiment, the pharmaceutical storage container has a weight of about 9 Kg. As an example, in one embodiment, the pharmaceutical storage container has a weight of about 10 Kg. As an example, in one embodiment, the pharmaceutical storage container has a weight of about 11 Kg. As an example, in one embodiment, the pharmaceutical storage container has a weight of about 12 Kg. As an example, in one embodiment, the pharmaceutical storage container has a weight of about 13 Kg. As an example, in one embodiment, the pharmaceutical storage container has a weight of about 14 Kg. As an example, in one embodiment, the pharmaceutical storage container has a weight of about 15 Kg. As an example, in one embodiment, the pharmaceutical storage container has a weight in the range of between about 16 Kg and about 25 Kg. In certain embodiments, the pharmaceutical storage container has a weight ranging between about 26 Kg and about 50 Kg.

  In certain embodiments, the pharmaceutical storage container described herein has a general size and shape of a refrigerator or freezer with an open top, standard for use for medical installations. As an example, in one embodiment, the pharmaceutical storage container has about 1 square meter. As an example, in one embodiment, the pharmaceutical storage container has a side length of about 1 m or less. In certain embodiments, the pharmaceutical storage container has a total internal volume of about 10 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 20 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 25 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 30 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 35 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 40 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 45 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 50 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 55 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 60 liters. In certain embodiments, the pharmaceutical storage container has a total internal volume of about 65 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 70 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 75 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 80 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 85 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 90 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 95 liters. In one embodiment, the pharmaceutical storage container has a total internal volume of about 100 liters.

  Some embodiments of the pharmaceutical storage container include a drying unit, a heating element, a controller, a cooling unit, a compression system, a steam line, a steam control unit, a thermal control unit, and a pharmaceutical storage unit. And including. The drying unit has one or more outer walls. The one or more outer walls are sealed together to form a gas-impermeable (impermeable) seal around the inner dry region. The one or more outer walls include an opening. The heating element is arranged in the internal drying area. The controller is operably attached to the heating element. The cooling unit has one or more outer walls. The one or more outer walls are sealed together to form a gas and liquid impervious seal around the inner evaporation region. The one or more outer walls include an opening. The compression system includes at least one evaporator coil unit disposed in the internal evaporation region of the cooling unit. The compression system is operably connected to the controller. The steam pipe (steam piping) includes a first end (first end) and a second end (second end). The steam line is attached to the outer surface of one or more outer walls that surround the opening of the drying unit at the first end. The steam line is attached to the outer surface of the one or more outer walls that surround the opening of the evaporation unit at the second end. The steam line forms a gas-impermeable internal path between the internal drying area of the drying unit and the internal evaporation area of the cooling unit. The steam control unit is attached to the steam line. The steam control unit is operably connected to the controller. The thermal control unit is attached to the steam line. The thermal control unit is operably connected to the controller. The drug storage unit includes one or more outer walls that surround a drug storage area. The pharmaceutical storage area includes at least one temperature sensor operably connected to the controller.

  The symbols shown in the drawings of this specification are not necessarily drawn to be reduced for the sake of explanation.

FIG. 1 illustrates an embodiment of a medicine storage container 100. FIG. 1 is a schematic view of a substantial cross section viewed from the side in order to illustrate the internal configuration of the pharmaceutical storage container 100. The medicine storage container 100 includes a medicine storage unit on the left side in FIG. The drug storage unit includes an outer wall 151 surrounding the drug storage area 150. In some embodiments, the drug storage unit has one or more walls adjacent to the drug storage area, such that the one or more walls are such that the drug storage area is thermally conductive at a desired temperature. Is provided. In some embodiments, the outer wall is formed of a hard plastic material. The outer wall 151 is
There may be an opening that allows access to the interior.

  The pharmaceutical storage unit comprises at least one or more temperature sensors, the temperature sensors being operably attached to the controller of the pharmaceutical storage container. As an example, the temperature sensor is arranged and configured to detect the temperature of the space in the pharmaceutical storage unit. Here, the drug storage unit is intended to be used for one or more drugs such as vaccines and biologics. By way of example, as illustrated in FIG. 1, in one embodiment, the pharmaceutical storage unit includes at least one temperature sensor 159 that is attached to the controller 170 by a wire connector 157. In one example, the temperature sensor may be an electrical temperature sensor. In one example, the temperature sensor may be a chemical temperature sensor. In one example, the temperature sensor may be a mechanical temperature sensor. In one example, the temperature sensor may be a temperature sensor using bimetal. In one example, the temperature sensor may be a thermocouple. In one example, the temperature sensor may comprise a low energy temperature sensor, such as a Thermodo device (Robocat, Copenhagen, Denmark). In one embodiment, the drug storage unit includes at least one temperature sensor, the temperature sensor being arranged and configured to detect a temperature in a space that occupies the drug storage area. In one embodiment, the drug storage unit includes at least one temperature sensor that is arranged and configured to sense the temperature of the outer wall of the drug storage area. In certain embodiments, the at least one temperature sensor is mounted in the drug storage area, for example at a location on the outer wall where there is heat conduction through the outer wall. In certain embodiments, the at least one temperature sensor is mounted in a recess or recess in the outer wall of the drug storage area, the recess or recess being directed toward the interior space of the drug storage area. Are arranged as follows.

  In one embodiment, the drug storage unit of the drug storage container comprises a switchable lid integral with the opening in the opening accessible to the inside of the outer wall. In one example, as shown in FIG. 1, the medicine storage unit includes a lid 155 that is attached to the medicine storage container 100 via a hinge 153 and can be attached in a switchable manner. In the embodiment shown in FIG. 1, the hinged lid is configured to allow the user to open upward. In FIG. 1, the opening / closing direction of the lid 155 is indicated by a bidirectional arrow. In one embodiment, the drug storage unit of the drug storage container internally includes a shelf or frame configured to store one or more drugs in drug storage. In one example, the drug storage unit of the drug storage container allows medical specialists such as veterinarians to store one or more secondary packaged vaccine injections for storage prior to using the vaccine injection. You may have one or more shelves of size and shape. The shelf or frame may be attached to the outer wall of the drug storage unit. The shelves or frames may be placed in association with access to the interior through a switchably attached lid. Some embodiments additionally comprise an article such as a bar code scanner, a radio frequency identification (“RFID”) tag reader, or a component with tracking capability. In some embodiments, a light source, such as an LED, is provided that is arranged to illuminate the interior of the pharmaceutical storage unit.

  In certain embodiments, the total internal volume of the drug storage unit of the drug storage container is between about 1 liter and about 5.0 liters. In certain embodiments, the total internal volume of the drug storage unit of the drug storage container is between about 5 liters and about 10.0 liters. In certain embodiments, the total internal volume of the drug storage unit of the drug storage container is between about 1.5 liters and about 4.0 liters. As an example, in one embodiment, the total internal volume of the drug storage unit of the drug storage container is about 1.5 liters. As an example, in one embodiment, the total internal volume of the drug storage unit of the drug storage container is about 2.0 liters. As an example, in one embodiment, the total internal volume of the drug storage unit of the drug storage container is about 2.5 liters. As an example, in one embodiment, the total internal volume of the drug storage unit of the drug storage container is about 3.0 liters. As an example, in one embodiment, the total internal volume of the drug storage unit of the drug storage container is about 3.5 liters. As an example, in one embodiment, the total internal volume of the drug storage unit of the drug storage container is about 4.0 liters. As an example, in one embodiment, the total internal volume of the drug storage unit of the drug storage container is about 5.0 liters. As an example, in one embodiment, the total internal volume of the drug storage unit of the drug storage container is about 7.5 liters. As an example, in one embodiment, the total internal volume of the drug storage unit of the drug storage container is about 10.0 liters.

  In the embodiment shown in FIG. 1, the medicine storage container 100 includes a cooling unit, and the cooling unit is disposed between the medicine storage unit and the drying unit. In the illustrated embodiment, the cooling unit comprises a first side wall disposed adjacent to the pharmaceutical storage unit and a second side wall disposed adjacent to the drying unit. In the embodiment shown in FIG. 1, the cooling unit is arranged approximately at the center of the medicine storage container 100. In some embodiments, a plurality of cooling units are provided. By way of example, in an embodiment, two cooling units are provided, the two cooling units being arranged adjacent to the side wall of one pharmaceutical storage unit of the pharmaceutical storage container. By way of example, in one embodiment, four cooling units are provided, each cooling unit adjacent to one of the four sidewalls of the drug storage unit that is substantially rectangular in shape, forming a drug storage container. Arranged. As an example, some embodiments include two cooling units, each positioned adjacent to the various drug storage units that make up the drug storage container.

  In one embodiment, the cooling unit for the medicine storage container is provided in an upper region provided adjacent to the opening of the outer wall, a lower region provided below the upper region, and substantially in the lower region. And an evaporative liquid. In an embodiment, the cooling unit of the medicine storage container comprises at least one evaporable liquid in the internal evaporation region of the evaporative cooling unit. In the present specification, the “evaporable liquid” is a liquid having a property of evaporating under a desired temperature and pressure in the internal region of the evaporation unit when the pharmaceutical storage container is used. As an example, in one embodiment, the internal evaporation area of the evaporation unit is about 5% partial pressure outside the drug storage container and the evaporable liquid in the internal evaporation area includes water. As an example, in one embodiment, the internal evaporation region of the evaporation unit is about 10% partial pressure outside the pharmaceutical storage container, and the volatile liquid of the internal evaporation region includes methanol. As an example, in one embodiment, the internal evaporation region of the evaporation unit is about 5% partial pressure outside the pharmaceutical storage container, and the volatile liquid of the internal evaporation region includes ammonia. In some embodiments, the evaporable liquid may further include a chemical that promotes or inhibits evaporation of the evaporable liquid. The volume of evaporable liquid used in certain embodiments is the type of evaporable liquid, the temperature range within the drug storage area when the container is used, the desired temperature of the evaporative coil unit, and the container used. It tends to depend on factors including the type of insulation and the location and quantity. In some embodiments, the total volume of evaporable liquid used may be about 90% volume of the total volume of the internal evaporation area of the evaporation unit. In some embodiments, the total volume of evaporable liquid used may be about 85% volume of the total volume of the internal evaporation area of the evaporation unit. In some embodiments, the total volume of evaporable liquid used may be about 80% of the total volume of the internal evaporation area of the evaporation unit.

  In certain embodiments, the cooling unit for the drug storage container is configured to be disposed adjacent to two or more side portions of the drug storage area. By way of example, in one embodiment, the cooling unit of the drug storage container is configured to be disposed adjacent to the three sides of the drug storage area. By way of example, in one embodiment, the cooling unit for the drug storage container is configured to be positioned adjacent to the four sides of the drug storage area.

  In certain embodiments, the drug storage area of a drug storage container has a substantially circular outer shell and further includes an outer surface that is arranged and configured to switch and match the circular outer shell. One or more walls having a cooling unit are provided.

  In an embodiment, the cooling unit of the pharmaceutical storage container has a liquid holding unit connected to at least one surface adjacent to the internal evaporation region. In certain embodiments, the liquid holding unit is connected to at least one of the inner surfaces of the internal evaporation region of the evaporative cooling unit. In some embodiments, the liquid holding unit is connected to at least one of the surfaces adjacent to the internal evaporation region of the evaporative cooling unit. The liquid holding unit has, for example, a small amount of water droplets or movement of evaporable liquid in the internal evaporation zone and a water droplet or vaporization into the vapor line during transportation or movement of the pharmaceutical storage container It may be provided to minimize liquid movement. For example, the liquid holding unit may comprise a mesh or screen having holes suitable to substantially prevent liquid drops from passing through. The liquid holding unit allows gas and liquid vapor passing through the liquid unit to flow freely, while preventing a large amount of liquid from becoming, for example, water droplets or small water droplets.

  In the embodiment shown in FIG. 1, the pharmaceutical storage container 100 comprises a cooling unit having one or more outer walls 115, the one or more outer walls being gas impermeable and liquid surrounding the inner evaporation region 110. Sealed together to form an impermeable partition, the one or more outer walls have an opening 133. In the embodiment shown in FIG. 1, the opening 133 is disposed in the upper surface of the outer wall 115 of the cooling unit. The opening 133 is attached to the first end of the vapor line 130 that seals liquid and vapor.

  As shown in FIG. 1, the steam line 130 of the medicine storage container 100 has a first end 180 and a second end 185, and the first end 180 and the second end 185 of the steam line 130 are These are attached to the evaporation unit 110 and the drying unit 120, respectively, and are attached to positions adjacent to the upper ends of the evaporation unit 110 and the drying unit 120, respectively. In the present specification, the “tube (pipe)” indicates a structure having a hollow inside and having at least two openings at the end, such as a pipe, a tube, and a duct. In certain embodiments, the hollow portion inside the tube is substantially circular in cross section. In certain embodiments, the hollow portion within the tube is substantially rectangular, oval or irregular in cross section. In some embodiments, the exterior of the tube is box-shaped or rectangular, while the continuous space within it is partially hollowed out. As used herein, “steam line” refers to a pipe for a gas that includes an evaporative liquid that is in the vapor state to travel through the steam line. In some embodiments, the vapor line 130, the evaporation unit 110, and the drying unit 120 are provided as separate components and are connected to each other by a gas impermeable seal. In an embodiment, the steam line 130, the evaporation unit 110, and the drying unit 120 may be provided substantially integrally with, for example, blow molded plastic or metal. For example, one or more parts may be made of polycarbonate resin. For example, one or more parts may be made of aluminum or stainless steel. In the embodiment shown in FIG. 1, the vapor control unit 140 is visible, but in some embodiments, the vapor control unit 140 is completely inside the vapor line 130 and is not visible from the outside of the drug storage container 100. .

The steam control unit is disposed at the junction between the first end of the steam line and the second end of the steam line. In one embodiment, a steam control unit is shown in the interior space of the steam line. In some embodiments, the steam control unit is entirely inside the steam line. In some embodiments, the steam control unit comprises one or more components that are external to the steam line. The steam control unit has a valve region and a control region. The control area is connected to the controller via a wire connector, for example. The control unit is arranged and configured to be able to switch the suppression of the flow of steam through the steam line. The steam control unit may be configured to switchably control the flow of steam through the steam line based on a signal received from the controller.In one embodiment, the steam control unit may be At least one valve provided to control the movement of gas through the internal flow path of the steam line between the internal drying area and the internal evaporation area of the evaporative cooling unit, the at least one valve being controlled It is comprised so that it may operate | move based on the signal received with the device. The steam control unit may have a mechanical valve, such as a butterfly valve. The steam control unit may operate mechanically. The steam control unit may include a motor configured to operate the valve. In some embodiments, the valve is a butterfly valve and is in direct physical connection with the control area of the steam control unit. The valve operates in response to a signal transmitted by the controller, which is connected, for example, via a wire connector between the steam control unit and the controller. The valve is arranged and sized within the valve region so that it can assume at least two positions, a substantially open position and a substantially closed position. When the valve is in the substantially open position, the gas containing steam between the first end of the steam line and the second end of the steam line depends on the size of the valve in the valve area of the steam control unit. Can flow freely, and the gas pressures at the first end of the steam line and the second end of the steam line become equal. The valve is sized and shaped to substantially block the flow of gas between the first end of the steam line and the second end of the steam line when in the substantially closed position. Have. In some embodiments, the steam control unit valve is directly connected to the motor. By way of example, in some embodiments, the motor is a servo motor. For example, in certain embodiments, the motor is a stepper motor. The motor is directly connected to the valve and opens and closes the valve upon receipt of a signal from the controller. The motor may be directly connected to the controller via a wire connector. In certain embodiments, the valve has one or more intermediate positions that partially obstruct gas flow through the valve between the first end of the steam line and the second end of the steam line. However, the intermediate position does not completely block the gas flow. For example, a valve may cause a flow of gas through a “half flow” position, ie, between the first end of the steam line and the second end of the steam line, relative to the fully open position. The position is reduced to about half. For example, the valve may allow a fully open gas flow through the valve, i.e. through the valve and therefore between the first end of the steam line and the second end of the steam line. It has a position that decreases to about a quarter of the position.

  In certain embodiments, the pharmaceutical storage container comprises an optical transmission unit. As an example, the control region of the steam control unit may include a transmission unit including an antenna and a circuit that transmits a signal from the antenna. The circuit that transmits the signal from the antenna responds to the controller, for example, the circuit that transmits the signal from the antenna transmits a signal based on the data received from the controller (for example, data from the sensor, operation of the motor Or one or more data points based on the results of calculations performed by the controller). The transmission unit may be, for example, a Bluetooth (registered trademark) unit. The transmission unit may be an infrared transmitter, for example.

  In certain embodiments, the steam control unit comprises a valve region having a valve and a movable unit. The movable unit is physically attached to the valve and applies a physical force to the valve in response to a stimulus. As an example, in one embodiment, the movable unit is a crank mechanism attached to a valve. By way of example, in some embodiments, the movable unit comprises a lid and a valve stem mounted inside the valve, the valve comprising a disk and a physical seat for the disk. For example, in one embodiment, the valve region includes a valve in a region where the steam line is physically deformable and a movable unit, the movable unit comprising at least two physical components. The component is arranged to press the opposing outer surface of the physically deformable region of the steam line in response to a signal from the controller. For example, in one embodiment, the valve region comprises a valve and further comprises a physically deformable region of the steam line and a movable unit having a reversible clamp outside the valve, the movable unit being connected to the controller. It is operably attached. In certain embodiments, the movable unit comprises a motor. In some embodiments, the movable unit is entirely within the steam control unit. In certain embodiments, the movable unit comprises one or more components external to the steam control unit. In some embodiments, the movable unit comprises one or more components that operate passively, such as bimetallic components whose configuration varies with temperature.

  In certain embodiments, the pharmaceutical storage container comprises one or more insulation sections that cover the cooling unit and the pharmaceutical storage unit. As an example, FIG. 1 shows a pharmaceutical storage container 100 having a thermal insulation 113 covering a cooling unit and a pharmaceutical storage unit. For example, the heat insulating material may be a foam heat insulating material. By way of example, the insulation may be one or more vacuum insulation panels (VIP panels).

  By way of example, the insulation may comprise one or more panels consisting of providing a multilayer insulation material surrounded by a vacuum space in an inner layer. As an example, the heat insulating material may comprise a heat insulating material made of glass fiber. As an example, the thermal insulation may be a ceramic thermal insulation material. The type and amount of insulation may be selected based on factors including the desired temperature range in the drug storage area, the desired temperature range in the container, and the amount of power used by the container supplied from the outside. Good.

  The pharmaceutical storage container includes at least one evaporator coil unit. In one embodiment, at least one evaporator coil unit is located adjacent to the outer wall of the container. In an embodiment, at least one evaporator coil unit is provided inside the container in an adjacent area with respect to the vacuum space of the internal evaporation area in the cooling unit. In an embodiment, at least one evaporator coil unit is provided in the internal evaporation region of the cooling unit. As an example, in the embodiment shown in FIG. 1, the evaporator coil unit is provided substantially at the center in the internal evaporation region 110 of the cooling unit. In one embodiment, at least one evaporator coil unit is provided adjacent to the outer wall of the cooling unit proximate to the drying unit. In an embodiment, at least one evaporator coil provided in the internal evaporation region of the cooling unit is provided in the internal evaporation region of the cooling unit, which is disposed substantially in the center of the cooling unit. In one embodiment, at least one evaporator coil unit provided in the internal evaporation region of the cooling unit is provided adjacent to the outer wall of the cooling unit proximate to the pharmaceutical storage unit.

  In certain embodiments, the cooling unit comprises one or more thermally conductive components attached to at least one evaporator coil unit. As an example, one or more thermally conductive components may be provided in the internal evaporation region. By way of example, the cooling unit may comprise one or more heat fins and / or heat flanges attached to an evaporator coil unit disposed in the internal evaporation region, the one or more heat fins and / or Or a thermal flange is arrange | positioned so that the heat energy between the inside of a cooling unit and the coil unit for evaporators can be transmitted. As an example, the cooling unit may comprise one or more heat fins and / or heat flanges attached to an evaporator coil unit disposed in the internal evaporation region. The one or more heat fins and / or heat flanges are arranged to transfer heat energy between the liquid held inside the cooling unit and the coil unit for the evaporator. The heat conducting component may be formed of a heat conducting metal such as aluminum or copper.

  The embodiment of the pharmaceutical storage container 100 in FIG. 1 comprises a compression system 160 having at least one evaporator coil unit 190 disposed in the internal evaporation region 110 of the cooling unit. The compression system 160 is operably attached to the controller 170. In the embodiment of FIG. 1, the evaporator coil unit 190 is provided substantially at the center of the internal evaporation region 110. In an embodiment, the evaporator coil unit is provided substantially outside the internal evaporation region. The internal evaporation region 110 is sealed so that gas and liquid cannot permeate, and the evaporator coil unit 190 disposed in the internal evaporation region 110 of the cooling unit uses a wire in an empty portion of the compression system 160. And connected across the lower wall of the cooling unit. The compression system is operably attached to the controller. By way of example, in the embodiment shown in FIG. 1, the compression system 160 is connected to the controller 170 using wires 165. In the embodiment shown in FIG. 1, the compression system 160 is connected to the controller 170 by a wire 165 that traverses the lower wall 115 of the internal evaporation region 110. In some embodiments, one or more wires may be provided across the side wall surface or the top wall surface. The wire traversing the wall may include a seal adjacent to the wall so that a seal can be achieved against gases and liquids from around the interior evaporation region.

  In some embodiments, the compression system may comprise a single stage compression system. In some embodiments, the compression system includes an evaporator coil unit disposed in the internal evaporation region, the evaporator coil unit being connected to a compressor, a condenser, and an expansion valve in the closed loop system. The compressor, the condenser, and the expansion valve are provided outside the internal evaporation area, which is an area adjacent to the medicine storage container. In one embodiment, the compression system comprises at least one evaporator coil unit, a compressor unit, a condenser unit, and a metering device. The at least one evaporator coil unit is provided in the internal evaporation region of the cooling unit, and the metering device is disposed outside the internal evaporation region of the cooling unit. The metering device may include, for example, an expansion valve. The metering device may comprise a capillary tube metering device, for example.

  In the embodiment of FIG. 1, the evaporator coil unit 190 is provided in the internal evaporation region 110 of the cooling unit, and the refrigerant tube crosses the lower wall of the internal evaporation region 110 of the cooling unit. Is connected to an empty part of the compression system 160 which is arranged adjacent to the cooling unit. In the place where the refrigerant tube crosses the wall of the internal evaporation region of the cooling unit, the gas and the liquid are sealed with an impermeable sealing portion, so that the liquid having the evaporation property in the internal evaporation region of the cooling unit can be held. In some embodiments, the compression system includes a switch that can turn the compression system on and off in response to a signal received from the controller.

  In certain embodiments, the cooling unit comprises one or more temperature sensors in the internal evaporation region, and the one or more temperature sensors are operably attached to the controller. One or more temperature sensors may be attached to the controller with a priority connection, for example. FIG. 1 shows a temperature sensor 119, which is located in the internal evaporation region 110 of the cooling unit and is attached to the controller 170 by wire connection.

  The one or more temperature sensors may be electrical temperature sensors, for example. The one or more temperature sensors may be, for example, chemical temperature sensors. The one or more temperature sensors may be, for example, mechanical temperature sensors. The one or more temperature sensors may be temperature sensors using bimetal. The one or more temperature sensors may be thermocouples, for example. The one or more temperature sensors may be low energy temperature sensors, such as, for example, a Thermodo device (Robocat, Copenhagen, Denmark). One or more temperature sensors in the internal evaporation region may be arranged to detect the temperature of the evaporating liquid at any position within the internal evaporation region. One or more temperature sensors in the internal evaporation region may be arranged to detect the temperature of a space at an arbitrary position in the internal evaporation region. One or more temperature sensors in the internal evaporation zone are configured to be able to transmit a signal relating to the temperature sensed regularly, for example every second, every 5 seconds, or every 10 seconds. Yes. One or more temperature sensors in the internal evaporation region are configured to transmit a signal regarding the detected temperature after receiving a query signal from the controller.

  The medicine storage container includes a controller, and the controller is arranged so that other components of the medicine storage container can function regularly. The controller may be an electric controller. For example, in one embodiment, the electrical controller is a “bang-bang” controller. For example, in certain embodiments, the electrical controller is a boundary system controller. For example, in certain embodiments, the electrical controller is a threshold system controller. For example, in certain embodiments, the electrical controller is a feedback system controller. For example, in certain embodiments, the electrical controller is a PID controller. The controller includes a memory, and may be an electronic memory, for example. In certain embodiments, the controller may include a reference table, for example, the reference table may be configured with a range of desired parameters such as temperature, pressure, etc. for the units in the container. In certain embodiments, the controller may include a calculated parameter, for example, in a pharmaceutical storage area that is relative to a temperature external to the container in certain embodiments. It may be an expected thermal diffusion parameter. The controller is operably attached with the compression system. According to the embodiment of FIG. 1, the controller 170 is connected to the compression system 160 via a wire connector 165. In some embodiments, the controller is connected to the compression system 160 via a wireless connection. The controller is connected to the power source. In some embodiments, the controller is connected to an electrical power source. As an example, in one embodiment, the controller is connected to a municipal power source. The power source is a generator, a photovoltaic panel, or other electrical power source. In the embodiment shown in FIG. 1, the controller 170 is attached to the wire connector 175, and may be connected to a municipal power source, for example, via an outlet attached to a wall surface.

  The controller may include circuitry that performs specific operations and processes. For example, the controller receives data from the attached sensor and determines if the data is within a predetermined range, and the controller is directed to the motor if the data is above or below the predetermined range. A signal to open or close the valve of the steam control unit. For example, in one embodiment, the controller receives data generated by the temperature sensor, compares the data to a predetermined temperature range, and the data from the temperature sensor indicates that the sensed temperature exceeds the predetermined range. In some cases, the controller sends a signal to the motor to open the valve. For example, in one embodiment, the controller receives data generated by the temperature sensor, compares the data to a predetermined temperature range, and the data from the temperature sensor indicates that the detected temperature is within the predetermined range. In the case shown, the controller does not send a signal to the motor. For example, in one embodiment, the controller receives data generated by the temperature sensor, compares the data to a predetermined temperature range, and the data from the temperature sensor indicates that the detected temperature is less than the predetermined range. In the case shown, the controller sends a signal to the motor to close the valve. In one embodiment, the predetermined temperature range in the data obtained from the temperature sensor in the pharmaceutical storage area is 2 ° C to 8 ° C. In some embodiments, the predetermined temperature range is 3 ° C to 7 ° C. In some embodiments, the predetermined temperature range is -2 ° C to + 2 ° C. In certain embodiments, the predetermined temperature range is from -3 ° C to -7 ° C.

  In some embodiments, the controller calculates an error value between data received from the sensor and a predetermined target value. The calculation may include data received over time, i.e., may include multiple data points received from a single sensor. The calculation may include data received from multiple sensors. In response to the calculated error value, the controller can calculate a predicted error value in the future. The circuit then calculates the combined error value. If the error value calculated from the combination of the previously calculated error value, the current error value, and the future error value exceeds the set point, the circuit will To send a signal to open the valve. For example, in a steam control unit according to an embodiment, the set point is 5 ° C. In some embodiments, the error value calculated by a combination of a previously calculated error value, a current error value, and a future error value is higher than a predetermined set point (eg, 8 ° C.). In some cases, the controller sends a signal to the motor to open the attached valve. Similarly, in some embodiments, an error value calculated by a combination of a previously calculated error value, a current error value, and a future error value is a predetermined set point (eg, 2 ° C.). If so, the controller sends a signal to the motor to close the attached valve.

  In certain embodiments, the controller is operably attached to one or more temperature sensors, the steam control unit, and the heating element in the internal drying area. The controller is configured to receive a signal from a component such as, for example, a temperature sensor and to send a signal to the component. By way of example, the controller sends a signal to the vapor control unit in response to a signal indicating an elevated temperature in the drug storage area. With this type of signal, the vapor control unit can open the valve in the vapor line, thereby promoting the evaporative cooling in the evaporative cooling region and, as a result, lowering the temperature in the drug storage region. In the embodiment in FIG. 1, the controller 170 is operatively connected by a temperature sensor 159 and a wire connector 157 disposed in the pharmaceutical storage area 150. The controller 170 is operatively connected to the steam control unit 140 by a wire connector 157. Similarly, the controller 170 is operatively connected to the heating element 127 in the drying area 120 by a wire connector. In certain embodiments, the controller comprises circuitry to control the operation of the heating element in response to a signal received from at least one temperature sensor in the pharmaceutical storage area. In certain embodiments, the controller is operably attached to the heating element and the at least one temperature sensor via a wire connector.

  In some embodiments, the drug storage container may include a thermal insulation that covers the drug storage unit and the cooling unit. As an example, in the embodiment shown in FIG. 1, the medicine storage container 100 includes a heat insulating material 113 that covers an outward portion facing the outer wall 151 of the medicine storage unit and an outward portion facing the outer wall 115 of the cooling unit. It may be. The heat insulating material may face the outer wall of the cooling unit adjacent to the drying unit and may be disposed outward. In certain embodiments, a thermal insulation disposed between each outer surface facing the outer wall between the drug storage unit of the drug storage container, the cooling unit, and the drying unit may be provided. As an example, in the embodiment shown in FIG. 1, the heat insulating material 117 is disposed between a surface facing the outer wall 151 of the cooling unit and a surface facing the outer wall 115 of the cooling unit. In some embodiments, the thermal insulator may be, for example, a foamable thermal insulator. In some embodiments, by way of example, the insulation may be one or more vacuum insulation panels (VIP panels). In some embodiments, no additional insulation is provided outside the drying unit, for example, so that heat can diffuse from the outer surface of the drying unit of the container during heat absorption.

  In one embodiment, the one or more heat transfer units are provided within the insulation, the insulation being between the surfaces of the pharmaceutical storage unit adjacent to the outer wall of the cooling unit that face the outer wall. Has been placed. For example, the heat transfer unit may include one or more thermosiphons or one or more heat pipes arranged to facilitate heat transfer from the inside of the pharmaceutical storage container to the inside of the cooling unit; One or more steam chambers may be provided. In some embodiments, by way of example, a heat pipe may be provided in the insulation, the insulation being disposed between opposing surfaces of the outer wall of the pharmaceutical storage unit adjacent to the outer wall of the cooling unit. Yes. The heat transfer unit may, for example, be arranged so that heat energy or heat can be transferred from the inside of the medicine storage container to the inside of the cooling unit.

  In certain embodiments, the pharmaceutical storage container comprises a base unit below the pharmaceutical storage container, the base unit comprising at least one wall that substantially covers at least the area of the compression system and the controller. ing. As an example, FIG. 1 shows a pharmaceutical storage container 100 with a base unit 105. The substrate may be, for example, a framework or an enclosed box structure formed of metal or plastic. By way of example, the substrate may be positioned such that the top surface of the pharmaceutical storage container is at a height that can be handled, for example, by medical personnel.

  The medicine storage container includes a drying unit having one or more outer walls, and the one or more outer walls are sealed around the inner drying area so as to form a gas-impermeable partition wall. . In certain embodiments, the outer wall comprises a conductive material such as a thermally conductive metal. The outer wall includes an opening, and the opening is sealed with a sealing portion so that gas and liquid are impervious at the end of the vapor line. In the embodiment shown in FIG. 1, the medicine storage container 100 includes a drying unit 120. The drying unit includes a chamber that seals the steam, and the chamber includes an internal drying region in the steam that communicates with the internal region of the steam line. The drying unit 120 shown in FIG. 1 is attached to the second end of the steam line 130. The drying unit comprises a heating element arranged in the internal drying area. In the embodiment shown in FIG. 1, the drying unit 120 includes a heating element 127 that is substantially flat along the end wall of the internal evaporation region 110 of the cooling unit. Has been placed. In some embodiments, the heating element is an electrical heating element. In certain embodiments, the heating element is coil-shaped. In certain embodiments, one or more thermally conductive elements attached to the thermal heating element may be provided. As an example, a heat conductive fin or a heat conductive flange may be provided so as to dissipate heat from a heating element in the drying unit. In certain embodiments, the heating elements are arranged so that the drying material in the drying unit can be heated with a uniform distribution of heat. In an embodiment, the heating element is arranged adjacent to the inner wall surface of the drying unit. In an embodiment, the heating element is arranged on the outer wall of the drying unit, which heating element is arranged so that the drying material in the drying unit can be heated by heat conduction and / or convection.

  In certain embodiments, the drying unit comprises one or more units made of a dry material in an internal drying area. In some embodiments, the pressure in the drying unit is lower than the pressure in the internal drying area. In some embodiments, the pressure in the drying unit is less than 1 torr in the internal drying area. In some embodiments, the pressure in the drying unit is less than 0.1 torr in the internal drying area. In certain embodiments, the drying unit comprises an open cell metal foam disposed within the internal drying region and an open cell metal foam disposed to disperse the gas within the internal drying region. In certain embodiments, the drying unit comprises one or more pipes disposed within the internal drying region and one or more pipes disposed to disperse gas within the internal drying region.

  In certain embodiments, a thermal insulation is provided adjacent to one or more outer surfaces of the drying unit. By way of example, the insulation may be less thermally insulating than the insulation around the storage area in certain embodiments. In some embodiments, the thermal insulation unit is located adjacent to one or more outer surfaces of the drying unit. In some embodiments, the movable insulation unit is positioned adjacent to one or more outer surfaces of the drying unit. For example, the movable insulation unit may include a mechanical system that can be disposed adjacent to one or more outer surfaces of the drying unit and that can change the configuration of the insulation. As an example, the movable insulation unit may comprise a sliding panel that is configured to be movable over time so that it can cover more or less of the outer surface portion of the drying unit. Has been. In some embodiments, the movable insulation material is configured to allow the user to cover the exterior of the drying unit and then remove it.

  In one embodiment, the drying unit includes a one-way valve unit, and the one-way valve unit is configured to release a gas having a predetermined limit pressure or more out of an internal drying region of the drying unit. ing. By way of example, the drying unit may comprise a blowout valve that is configured to open when the pressure in the drying unit exceeds a predetermined maximum level. The one-way valve unit can be, for example, a safety feature of the container.

  The medicine storage container includes a steam line, and the steam line includes a first end and a second end, and the first end is one or more around the opening of the drying unit. And the second end is attached to the outer surface of the one or more outer walls around the opening of the evaporative cooling unit, and includes an internal drying area and an internal evaporating area of the cooling unit. A gas impervious internal flow path is formed between the two. The pharmaceutical storage container further includes a vapor control unit attached to the vapor line, the vapor control unit being operably attached to the controller. As an example, in FIG. 1, the steam line 130 is a non-linear tube-like structure. The steam line 130 includes a first end 180 that is sealed to an opening 133 in the internal evaporation region 110 of the cooling unit. The steam line 130 includes a second end 185 that is sealed to an opening 135 in the wall of the drying unit 120. The steam line 130 shown in FIG. 1 has a second end 185 that is substantially vertical and is fixed at a position inclined about 45 ° relative to the region of the first end. The steam line 130 includes a steam control unit 140 that includes a first end 180 that is inclined about 45 ° from the vertical second end 185 and a second substantially vertical. It is attached to the steam line 130 at a position in the vicinity of the joint with the end. The steam control unit 140 is connected to the controller 170 via a wire connector 145.

  In certain embodiments, the pharmaceutical storage container comprises a vapor line that prevents heat conduction between at least one outer wall of the cooling unit and at least one outer wall of the drying unit. It is a substantially tubular structure with a length and diameter that can be made. In certain embodiments, the pharmaceutical storage container comprises a vapor line that can minimize the conduction of thermal energy between the drying unit and the cooling unit. As an example, the steam line may be elongated and inclined so as to minimize the conduction of thermal energy between the drying unit and the cooling unit. In certain embodiments, the pharmaceutical storage container comprises a vapor line having one or more heat conducting elements attached to the outer surface of the vapor line. In some embodiments, the steam line comprises one or more heat fins made of a thermally conductive material, the heat fins being attached to the outer surface of the steam line. In certain embodiments, the pharmaceutical storage container comprises a vapor line that is gas impermeable between the gas impermeable wall and the first end of the vapor line and the drying unit. A sealing part and a gas-impermeable sealing part between the second end of the steam line and the cooling unit. The pharmaceutical storage container in an embodiment includes a sealed portion that can be broken from the outside over the internal path of the steam line. The sealed portion is configured to prevent the flow of gas (gas) through the internal path of the steam pipe. For example, the steam line may include a gas-impermeable membrane made of a brittle sealed portion that blocks the inner diameter of the steam line. The membrane can be damaged by an external force that strikes a location outside the steam line adjacent to the internal seal. In one embodiment, the pharmaceutical storage container includes a first temperature sensor and a second temperature sensor, the first temperature sensor being disposed at a position adjacent to the first end in the steam line and controlled. Is operably attached to the instrument. The second temperature sensor is provided adjacent to the second end in the steam line and is operably attached to the controller.

  The steam line includes the control unit attached to the steam line and the controller. In certain embodiments, the steam control unit is attached to a steam line. In some embodiments, the steam control unit is entirely inside the steam line and is not visible from outside the cooling unit. In some embodiments, the steam control unit is integral with the steam line. The steam control unit can control the increase and decrease of the internal volume of the pipe inside the steam control unit, the steam control unit, i.e. the first end of the steam line and the second end of the steam line; It is provided to change the flow rate of steam passing between the two. See “Calculating Pipe Sizes & Pressure Drops in Vacuum Systems,” Section 9- Technical Reference, Rietschle Thomas Company, incorporated by reference. In an embodiment, the steam control unit is at least provided to control the movement of gas through the internal flow path of the steam line between the internal drying area of the drying unit and the internal evaporation area of the evaporative cooling unit. One valve is provided, and the at least one valve is configured to be operable in response to a signal received from the controller. In some embodiments, the pharmaceutical storage container includes an accelerator connected to a controller that, when repelled or struck on the side of the container, signals a valve to bring the valve closer to the vapor control unit. Configured to send.

  In some embodiments, the steam control unit comprises a sensor arranged to detect one or more conditions inside the steam line. In certain embodiments, the steam control unit comprises a temperature sensor. In certain embodiments, the steam control unit comprises a pressure sensor. In certain embodiments, the steam control unit comprises a vacuum sensor. The sensor may be an electrical temperature sensor, a chemical temperature sensor, or a mechanical temperature sensor, depending on the embodiment. The sensor may comprise a low energy temperature sensor, for example a Thermodo device (Robocat, Copenhagen, Denmark). The sensor may include, for example, an electric gas pressure sensor or a mechanical gas pressure sensor according to the embodiment. The sensor for measuring the gas pressure may include a Bourdon tube pressure gauge. The sensor for measuring the gas pressure may include a gas pressure sensor using a diaphragm. The sensor for measuring temperature may be provided with a thermocouple, for example. The sensor may include a sensor in which a gas pressure sensor, a gas composition sensor, and a temperature sensor are combined. For example, the sensor may comprise a NODE device (Variable Technologies, Chattanooga, TN). In some embodiments, the sensor may comprise a power source such as a battery. In some embodiments, the sensor is connected to the controller and receives power from the controller via something like a wire connector.

  Some embodiments include a sensor that is a temperature sensor. The temperature sensor may include, for example, a mechanical temperature sensor. The temperature sensor may include, for example, an electric temperature sensor. As an example, some embodiments include one or more temperature sensors: a thermocouple, a bimetal temperature sensor, an infrared thermometer, a resistance thermometer, and a silicon bandgap thermometer.

  In some embodiments, a gas pressure sensor is provided. The gas pressure sensor may include, for example, a mechanical gas pressure sensor such as a Bourdon tube pressure gauge. The gas pressure sensor may include an expansion valve having a capillary tube. The gas pressure sensor may include, for example, an electric gas pressure sensor. As an example, in an embodiment, a vacuum sensor may be provided as a sensor. For example, the inside of the vapor line is substantially evacuated before using the container, that is, the gas pressure is lower than the atmospheric pressure, and the degree of vacuum is reduced by evaporation of the evaporating liquid. The data from the vacuum sensor indicates the rate of evaporation, i.e. the overall level of evaporation of the evaporable liquid in the container. In some embodiments, the gas pressure sensor may comprise a piezoresistive strain gauge, a capacitive gas pressure sensor, or an electromagnetic gas pressure sensor. In certain embodiments, the pressure sensor comprises a capacitive pressure sensor.

  The steam line comprises a steam control unit, which controls the flow of steam between the internal drying area of the drying unit and the internal evaporation area of the evaporative cooling unit. As shown in FIG. 1, in one embodiment, the steam line has a tubular structure that traverses between adjacent units. The steam line is provided so as to move the gas containing the evaporated steam to the internal drying area of the drying unit at the maximum evaporative cooling required for the container. As such, the size, shape and arrangement of the steam line is used in the size of the container, the temperature range required for the container, the degree to which the movement of steam in the steam line can be reversibly controlled, and in certain embodiments. Depends on factors such as the desiccant and the physical properties of the liquid. For example, in one embodiment, the target temperature range of the storage area is 0 ° C. to 10 ° C., and the pharmaceutical storage container can absorb about 1 liter of liquid water and a corresponding amount of chloride that can absorb more than 1 liter of water. And a desiccant containing calcium. See “The Calcium Chloride Handbook, A Guide to Properties, Forms, Storage and Handling,” DOW Chemical Company, August 2003, incorporated by reference. In one example in an embodiment where the pharmaceutical storage container comprises water as an evaporable liquid and calcium chloride as the desiccant, the portable cooling unit is first substantially evacuated (pressure is 300 millitorr). At this time, it is estimated that approximately 1 gram of water evaporates every hour when the valve is in the fully open position. Therefore, when the external ambient temperature is about 25 ° C, the evaporative cooling unit is held between 6 ° C and 9 ° C for about one month with 1 liter of water and 1.5 kilograms of calcium chloride. be able to. In one example, in one example in an embodiment where the pharmaceutical storage container comprises water as an evaporable liquid and calcium chloride as the desiccant, the portable cooling unit is first substantially evacuated (pressure Is estimated to evaporate about 2-5 grams of water per hour when the valve is in the fully open position. The rate of evaporation varies depending on the configuration of the embodiment and the use of the embodiment. In some embodiments, a sensor is provided within the steam control unit, and the sensor is operably connected to the controller by a wire connector. The sensor may be a temperature or pressure sensor, for example. In one embodiment, a plurality of temperature sensors are provided.

  When the container is in use, the temperature sensor is located within a range in which the medicine storage area can transmit data to the controller via a wire. The controller is configured to operably control the control unit in response to the received data. In certain embodiments comprising an electrical controller, the electrical controller receives data from one or more temperature sensors attached to the pharmaceutical storage area and the detected value is outside a predetermined range; Or it is determined whether it is within the range. Based on the determination result, the electric controller opens and closes the valve so that the temperature or pressure becomes a value within a predetermined range. For example, in one embodiment, if the electrical temperature sensor sends a signal that includes temperature data that is 9 ° C., the controller may receive the temperature data from 3 ° C. to 7 ° C., which is a predetermined temperature range. Determined to be out of range. In response to the determination, the controller sends a signal to the motor attached to the valve in the steam control unit so that the motor starts to open the valve. In another example, in one embodiment, if the temperature sensor transmits a signal that includes temperature information of 1 ° C., the controller may receive the temperature data from 3 ° C. to 7 ° C., which is a predetermined temperature range. It is determined that it is out of the range. In response to the determination, the controller sends a signal to the motor attached to the valve in the steam control unit so that the motor starts to close the valve.

  However, depending on the embodiment, the connection between the controller, the temperature sensor and the valve in the steam control unit can take various forms. For example, in one embodiment, the steam control unit comprises a thermocouple that is physically connected to a mechanical controller that transmits physical pressure to a valve control element that opens and closes the valve. Apply appropriate pressure. For example, in one embodiment, the temperature sensor transmits data about the detected temperature to the electrical controller over time via a wire or wireless such as infrared transmission or short wavelength wireless transmission (eg, Bluetooth®). An electric temperature sensor is provided.

  FIG. 2 illustrates one embodiment of a pharmaceutical storage container, showing the manner in which the container is in use. The embodiment shown in FIG. 2 has similarities to the embodiment shown in FIG. Referring to FIG. 2, the evaporation region 110 includes the evaporating liquid 200 at a lower portion thereof. The evaporable liquid has an upper surface 203 in the evaporation region 110 of the pharmaceutical storage container 100. A space 240 exists on the upper surface 203 of the evaporable liquid 200. The space 240 is arranged such that gas and vapor can freely flow between the space 240 above the evaporable liquid 200 and the first end 180 of the conduit 130.

  FIG. 2 also shows that a desiccant 250 is disposed in the drying unit 120. The unit of the desiccant 250 is made of at least one material having a drying property or a function of removing the liquid from the liquid contained in the surrounding space. The desiccant unit can, for example, act in the surrounding space to absorb water from water vapor or to absorb water. The unit of one or more desiccants is selected depending on the particular embodiment. Specifically, select a sufficient amount of desiccant necessary to absorb the liquid for the estimated time required to operate a specific evaporative cooling unit integrated in a specific container. Is done. In embodiments, the desiccant unit is selected from materials that are solid in routine operation. One or more desiccant units may include non-desiccant units such as, for example, a binding material, a scaffold material, or a support material. One or more desiccant units may contain more than one type of desiccant. The pharmaceutical storage containers shown herein are intended to be used for evaporative cooling for days or weeks, and sufficient desiccant and corresponding evaporable liquid may be used in any given embodiment for those periods of time. Included for. For more information on liquid-desiccant pairs, see Saha et al., “A New Generation Cooling Device Employing CaCl2-in-silica Gel-water System: International Journal of Heat 52, incorporated herein by reference. 516-524 (2009)). The choice of one or more desiccants used in a particular embodiment also depends on the range of target cooling temperatures in the particular embodiment. For example, in embodiments, the desiccant may include calcium carbonate. For example, in embodiments, the desiccant may include lithium chloride. For example, in embodiments, the desiccant may include liquid ammonia. For example, in embodiments, the desiccant may include zeolite. For example, in embodiments, the desiccant may include silicic acid. Further information about the drying agent, Dawoud and Aristov of "Experimental Study on the Kinetics of Water Vapor Sorption on Selective Water Sorbents, Silica Gel and Alumina Under Typical Operation Conditions of Sorption Heat Pumps" (International Journal of Heat and Mass Transfer, 46: 273-281 (2004)), Conde Petit “Aqueous Solutions of Lithium and Calcium Chlorides: -Property Form. ulations for Use in Air Conditioning Equipment Design "(M.Conde Enginnering (2009))," Zeolite / Water Refrigerators "(BINE Informationsdienst, projektifo 16/10)," Calcium Chloride Handbook: A Guide to Properties, Forms, Storage and Handling "(Dow Chemical Company (August 2003)", "Caocium Chloride, A Guide to Physical Properties" (Occidental Chemical Corporation). on, Form No. 173-01791-0809 P & M) and Restoccia et al., “Selective Water Sorbent for Solid Sorption Chiller: Exponential Results and Modulation, 27” Each of which is incorporated herein by reference. In embodiments, the desiccant is considered non-toxic under vigilance by routine processing. The desiccant may be selected according to any exothermic characteristics of the material in order to maintain the overall thermal properties of the pharmaceutical storage container required in certain embodiments.

  During use of the drug storage container, the drug storage container can be powered and operates in different modes depending on the state of the drug storage container. In situations where a reliable source of power is available, for example, the supply of a stable municipal power source, or solar power during operation, is sufficient to maintain a fixed temperature range within the drug storage area of the container. The dexterous coil may be operated. Information sent to the controller from at least one temperature sensor in the pharmaceutical storage area may include, for example, a signal for turning on or off the compression system necessary to maintain the proper temperature of the evaporating liquid. It may be based on the transmitting controller. The evaporable liquid may act as a thermal ballast to maintain the temperature in the drug storage container within a predetermined range with minimum temperature flow. In embodiments, the evaporative drying coil unit is configured to freeze the evaporable liquid to maintain an appropriate temperature in the pharmaceutical storage area. In embodiments, the evaporative drying coil unit is configured to cool the evaporable liquid to maintain an appropriate temperature in the pharmaceutical storage area. In embodiments, the pharmaceutical storage container includes a battery configured to store some power that operates the controller sufficiently when there is not enough power to operate the compression system.

  In some respects, it is anticipated that the power source of the drug storage container will no longer be available. For example, municipal power systems do not operate due to emergencies or lack of capacity, or solar power is not available at night. The heat capacity of the evaporative liquid depends on factors such as the heat capacity of the evaporative liquid, the thermal properties, the insulation parameters of the drug storage container, the temperature range of the storage area, and the ambient temperature of the container during the period maintain. When power to operate the compression system is not available, the controller continues to operate based on reserve power as supplied by the battery. When the temperature sensor sends a signal to the controller indicating that the drug storage area needs to be cooled in order to maintain the temperature of the drug storage area within the appropriate temperature range, the controller In order to increase the evaporation of the vapor, a valve in the vapor control unit is opened to allow vapor to reach the desiccant from the evaporating liquid. As a result, the cooling of the evaporative liquid continues to act as a thermal ballast for the drug storage area within the appropriate temperature range.

  Over time, a portion of the evaporative liquid initially present in the cooling unit is propagated inside the drying unit as the movement of the vapor through the vapor line. The container needs to be refilled with evaporative liquid from the drying unit periodically, and thus through the vapor line, in order to maintain the function of the container. Since the inside of the cooling unit, vapor line, and drying unit is a continuous area sealed with gas and liquid, the evaporable liquid can return to the cooling unit as a vapor to refill the system . In embodiments, the controller includes circuitry for operation of the container refill cycle. In embodiments, the controller is configured to accept a user input to initiate a refill cycle via a button or similar user input device operably connected to the controller.

  The controller includes a specific external power supply, including ambient temperature, the temperature of the evaporative liquid currently present in the cooling unit, the temperature in the pharmaceutical storage area, and input from the user in embodiments. Activate the refill cycle of the system based on predetermined factors for the embodiment. During refilling, the controller initiates heating of the heating material located in the drying area inside the drying unit. The heater is activated to a predetermined temperature for a predetermined period. Time and temperature settings for the heating material are based on the embodiment. For example, based on the type of desiccant and evaporable liquid present in the container and the size and shape of the drying unit and the drying area inside. For example, in embodiments, the heating material is fixed at 300 degrees Celsius for at least 30 minutes during the refill cycle. For example, in embodiments, the heating material is fixed at 250 degrees Celsius for at least 60 minutes during the refill cycle. While the heating material is hot, the evaporating liquid associated with the desiccant in the drying unit is converted to vapor. The steam travels through the steam line and condenses in the relatively cold, evaporating region of the cooling unit. After the heated material is turned off, the drying unit is cooled, for example by radiative cooling, and the refill cycle is completed. In embodiments, the controller is configured to initiate a refill cycle only when the compression system is in operation to ensure condensation of the evaporable liquid within the evaporation zone inside the cooling unit. ing. In embodiments, the controller is configured to initiate a refill cycle only when the ambient temperature of the container is below a predetermined threshold level to ensure sufficient radiant heating for the cooling process. ing. In embodiments, the drying unit includes a one-way valve configured to open when the air pressure in the drying unit exceeds a threshold level.

  The refill system is expected to be able to operate multiple times during use over the life of the container without changing the desiccant or evaporating liquid. For example, consider that a drug storage container is refilled monthly and operates for 10 years. At this time, it is expected that the desiccant and the evaporating liquid provided in the container can be refilled to enable reuse at least 120 times (12 times per year, 10 years). Yes. For example, consider a drug storage container being refilled every other week and operating for 5 years. At this time, it is expected that the desiccant and the evaporating liquid provided in the container can be refilled to enable reuse at least 130 times (26 times per year, 5 years). Yes. In embodiments, the pharmaceutical storage container is configured to allow at least 200 refills during multiple years of use of the container without changing the desiccant or evaporating liquid.

  The pharmaceutical container is configured to operate effectively in situations where low power and / or intermittent power is available. The pharmaceutical container is configured to operate effectively using a compressor-based cooling system when power is available. When power is not available, the evaporative liquid may be supplied as a thermal ballast to maintain cooling of the pharmaceutical storage area. When the evaporable liquid is warmed above a predetermined temperature, the evaporable liquid may be recooled through evaporative cooling in the absence of external power. Furthermore, the container may be refilled as required for the evaporative cooling system when external power is available and the external power guarantees the condition.

  FIG. 3 shows an embodiment of the medicine storage container 100. The embodiment shown in FIG. 3 includes a drug storage unit that includes an outer wall 151 that surrounds the drug storage area 150, the drug storage area 150 being operatively connected to a controller 170 having a wire connector 157. A sensor 159 is included. The pharmaceutical storage container 100 shown in FIG. 3 also includes a cooling unit including a plurality of outer walls 115. The plurality of outer walls 115 include openings 133 and seal the periphery of the inner evaporation region 110 so as to form a barrier impermeable to gas and liquid. The medicine storage container 100 includes a drying unit including a plurality of outer walls 320 that seal the periphery of the inner drying region 120 so as to form a gas-tight barrier. The plurality of outer walls 320 include openings 135. The pharmaceutical storage container 100 includes a steam line 130 including a first end 180 and a second end 185. The steam line 130 is connected to the outer surface of the plurality of outer walls 320 around the opening 135 of the drying unit at the second end 185. The steam line 130 is connected to the outer surface of the plurality of outer walls 115 around the opening 133 of the evaporative cooling unit at the first end 180. The steam line 130 forms a passage through which no gas passes between the internal drying region 120 of the drying unit and the internal evaporation region 110 of the cooling unit. The pharmaceutical storage container 100 also includes a heating element 127 disposed inside the internal drying region 120. The controller 170 is operably connected to the heating element 127. The illustrated embodiment includes a compression system 160 that includes an evaporative drying coil unit 190 disposed within an internal evaporation region 110 within the cooling unit. The compression system 160 is operatively connected to the controller 170.

  The embodiments include at least one liquid level sensor (liquid level sensor) disposed in the internal evaporation region of the evaporative cooling unit. The liquid level sensor is arranged and configured to detect the evaporable liquid level in the internal evaporation region. For example, in embodiments, the liquid level sensor is arranged and configured to detect the surface of evaporable liquid (eg, surface 203 shown in FIG. 2). For example, in embodiments, the liquid level sensor is arranged and configured to detect that the evaporative liquid level is at least as high as a particular position. The specific position is, for example, a minimum position set in advance so that there is sufficient evaporable liquid to maintain the thermal characteristics of the evaporative cooling unit. In the embodiment shown in FIG. 3, the internal evaporation region 110 surrounds the liquid level sensor 310. In embodiments, the liquid level sensor is a Hall effect sensor.

  In embodiments, the pharmaceutical storage container comprises a gap between the outer surface of one or more outer walls of the drying unit and the outer surface of one or more outer walls of the cooling unit. The embodiment shown in FIG. 3 includes a gap 300 disposed between the outer wall 320 of the drying unit and the adjacent outer wall 115 of the evaporative cooling unit 320. The gap may be configured as an empty space between adjacent side surfaces of the evaporative cooling unit and the drying unit, for example. A gap of sufficient size and shape minimizes the transfer of heat to the evaporative cooling unit and facilitates radiative cooling of the drying unit. In the embodiment shown in FIG. 3, both the evaporative cooling unit and the drying unit are attached to the bottom 105 of the pharmaceutical storage container at the lower surface of the unit.

  In embodiments, the pharmaceutical storage container comprises a gap disposed between an outer surface of one or more outer walls of the drying unit and an outer surface of one or more outer walls of the cooling unit, and one or more of the drying units. And a fan attached to the outer surface of the outer wall and having a size, shape and arrangement determined to circulate the air in the gap. In embodiments, the fan is a passively controlled fan and is configured to operate when the temperature in the gap reaches a pre-adjusted temperature. In embodiments, the fan is configured to operate whenever the heating element in the drying unit is in operation. Embodiments include a plurality of fans disposed in and / or around the gap, the plurality of fans being arranged and configured to increase the flow of air in the gap.

  For example, FIG. 3 illustrates one embodiment that includes a gap 300 disposed between the sidewall of the drying unit and the adjacent sidewall of the evaporative cooling unit. The pharmaceutical storage container 100 shown in FIG. 3 also includes a fan 305 disposed at the upper end of the gap 300. The fan is configured to circulate the air in the gap 300. In embodiments, the operation of a fan located adjacent to the gap is controlled by a controller. In some embodiments, the operation of the fan disposed adjacent to the gap is controlled by the controller in accordance with information from a temperature sensor disposed within the drying unit. In the illustrated embodiment, the fan 305 is connected to the controller 170 by a wire connector. In the illustrated embodiment, the temperature sensor 129 is also connected to the controller 170 by a wire connector.

  Embodiments include at least one temperature sensor disposed in the first end of the steam line and at least one temperature sensor disposed in the second end of the steam line. ing. A temperature sensor located in the first end of the steam line and in the second end of the steam line is operably connected to the controller. Temperature sensors located in the first end of the steam line and in the second end of the steam line may be configured to send sensor data to the controller by wire connection or wireless connection. Good. The controller may be configured to operate the control unit. The controller is disposed in the first end of the steam line and the second end of the steam line, for example, as well as sensor data from a temperature sensor disposed in the drug storage area of the container. The open / close state of the valve in the steam control unit is adjusted according to the sensor data from the temperature sensor.

  FIG. 4 illustrates aspects of one embodiment of the pharmaceutical storage container 100. The illustrated embodiment includes (i) a first temperature sensor 410 disposed within the first end 180 of the steam line 130, and (ii) a second end 185 of the steam line 130. And a second temperature sensor 400 disposed. Both the first temperature sensor 410 and the second temperature sensor 400 are connected to the controller 170 by a wire connector 145. Container 100 also includes a gap 300 disposed between (i) the outer wall of the drying unit and (ii) the outer wall of the evaporative cooling unit adjacent to the outer wall of the drying unit. The fan 305 is disposed inside the gap.

  Embodiments include a steam line with a plurality of heat conducting members attached to an outer surface. For example, in the embodiment shown in FIG. 4, the first end 180 of the steam line 130 includes a plurality of heat conducting members 420. The heat conducting member 420 is a heat radiating fin attached to the outer surface of the pipe line. Embodiments include a heat conducting member. The heat conducting member is a heat radiating fin attached to the inner surface of the pipe line. The fin is disposed in a space inside the pipe. The heat conducting member is configured and arranged to improve heat dissipation from the steam pipe, for example, in order to promote condensation of the evaporating liquid present on the inner surface of the steam pipe.

  Embodiments are configured to allow use of one or more evaporable liquids in a frozen state. For example, if external power is available, in order to obtain a temperature below the freezing point of a particular evaporative liquid when the container is in use, operate the refrigerator coil inside the evaporative cooling unit, A compression system may be configured. If (i) external power is not available, or (ii) external power is insufficient to maintain the drug storage area at a temperature below the freezing point of the evaporating liquid, the frozen evaporating liquid will be It may be used as a thermal ballast as appropriate.

  FIG. 5 illustrates aspects of one embodiment of the pharmaceutical storage container 100. In the illustrated embodiment, the container 100 includes a pharmaceutical storage area 150. A temperature sensor 159 is provided in the storage area. The temperature sensor 159 is connected to the controller 170 by a wire connector 157. The container 100 includes a liquid level sensor 310 disposed in the internal evaporation region 110 of the cooling unit. The liquid level sensor 310 is disposed in the vicinity of the wall of the cooling unit adjacent to the medicine storage area 150. The liquid level sensor is configured to transmit information related to the detected liquid level to the controller 170 via the wire connector 315. Further, the internal evaporation region 110 of the cooling unit includes an evaporator coil unit 190. The evaporator coil unit 190 is disposed near the wall of the cooling unit adjacent to the drying unit. The drying unit faces the wall of the cooling unit close to the medicine storage area 150. The two temperature sensors 510 and 520 are disposed in the internal evaporation region 110 of the cooling unit. The temperature sensor 510 which is one of these temperature sensors is disposed in the vicinity of the upper region of the liquid level sensor 310. The temperature sensor 520, which is the other of these temperature sensors, is disposed in the vicinity of the lower region of the liquid level sensor 310. The temperature sensors 510 and 520 arranged in proximity to the liquid level sensor 310 are configured to transmit temperature sensor data to the controller 170 via the wire connector 530. The container 100 may additionally include a third temperature sensor 500. The temperature sensor 500 is disposed in the vicinity of the opening 133 in the outer wall of the cooling unit attached to the first end 180 of the steam line 130.

  FIG. 6 shows aspects of one embodiment of the pharmaceutical storage container 100 similar to FIG. 5 at the stage of the use cycle of the pharmaceutical storage container 100. At the stage shown, external power is available, and the compression system 160 cools the evaporator coil unit 190 located in the internal evaporation region 110 of the cooling unit to a temperature below the freezing point of the evaporating liquid. Is working. For example, in embodiments, the evaporative liquid is water and the evaporator coil unit can cool the water to a temperature below 0 degrees Celsius. In the stage shown in FIG. 6, the evaporating liquid 200 includes a freezing part close to the evaporator coil unit 190 and a liquid part close to the liquid level sensor 310. The liquid part of the evaporating liquid 200 has a liquid surface 203 located in the internal evaporation region 110 of the cooling unit. The freezing part of the evaporating liquid 200 has a surface 600. The surface 600 is located between the evaporator coil unit 190 and the temperature sensors 510 and 520 in the internal evaporation region 110 of the cooling unit. The temperature sensors 510 and 520 are disposed close to the liquid level sensor 190.

  In some embodiments and use cases similar to FIG. 6, the compression system is operable if sufficient external power is available. The compression system can cool the evaporating liquid existing in the internal evaporation region of the cooling unit to a temperature lower than the freezing point of the cooling liquid using the coil unit for the evaporator. As time passes, a portion of the evaporable liquid freezes (eg, as shown in FIG. 6). When the supply of external power is terminated or interrupted, the cooled and frozen evaporative liquid functions as a thermal ballast to continue cooling the drug storage area. If the external power supply continues for a sufficient time, the temperature sensor located in the internal evaporation area of the cooling unit indicates that the internal cooling area is almost filled with frozen evaporative liquid. Information is supplied to the controller. Similarly, in embodiments, if the liquid level begins to freeze and the level sensor is no longer operating as expected for the freely moving liquid, the level sensor is controlled. May be configured to provide information to the vessel. The controller may send a signal to the compression system to stop or mitigate the operation of the evaporator coil unit depending on the acquired information. Subsequently, the controller uses a compression system to start or facilitate the operation of the evaporator coil at a later time in response to new information obtained from one or more temperature sensors or liquid level sensors. A signal may be transmitted.

  In embodiments, the pharmaceutical storage container comprises a drying unit, a heating element, a controller, a cooling unit, a compression system, a refrigeration unit, a steam line, a steam control unit, a pharmaceutical storage unit, including. The drying unit has one or more outer walls. The one or more outer walls are sealed together to form a gas impermeable (impermeable) barrier around the inner dry region. The one or more outer walls include an opening. The heating element is arranged in the internal drying area. The controller is operatively connected to the heating element. The cooling unit has one or more outer walls. The one or more outer walls are sealed together to form a gas and liquid impervious barrier around the inner evaporation region. The one or more outer walls include an opening. The compression system includes at least one evaporator coil unit disposed in the internal evaporation region of the cooling unit. The compression system is operatively connected to the controller. The refrigeration unit includes one or more walls. The refrigeration unit is in thermal contact with at least one evaporator coil unit disposed in the internal evaporation region of the cooling unit. The steam line includes a first end and a second end. The steam line is attached to the outer surface of one or more outer walls that surround the opening of the drying unit at the first end. The steam line is attached to the outer surface of the one or more outer walls that surround the opening of the evaporation unit at the second end. The steam line forms an internal gas impervious path between the internal drying area of the drying unit and the internal evaporation area of the cooling unit. The steam control unit is attached to the steam line. The steam control unit is operatively connected to the controller. The drug storage unit includes one or more outer walls that surround a drug storage area. The pharmaceutical storage area includes at least one temperature sensor operatively connected to the controller.

  FIG. 7 illustrates aspects of one embodiment of the pharmaceutical storage container 100. In embodiments, the pharmaceutical storage container 100 includes a drying unit with an outer wall 320. The outer wall 320 is sealed together to form a gas impervious barrier around the inner dry region 120. The outer wall 320 includes an opening 135. The embodiment shown in FIG. 7 includes a heating element 127 disposed in the internal drying region 120. The heating element 127 is connected to the controller 170 of the pharmaceutical storage container 100 by a wire connector. FIG. 7 also shows an embodiment of the pharmaceutical storage container 100 that includes a cooling unit with an outer wall 115. The outer wall 115 is sealed together to form a gas and liquid impervious barrier around the inner evaporation region 240. The outer wall 115 includes an opening 133. The illustrated embodiment includes a compression system 160 with an evaporator coil unit 190. The evaporator coil unit 190 is disposed in the internal evaporation region 240 of the cooling unit. The compression system 160 is operatively connected to the controller 170. In the illustrated embodiment, the evaporator coil unit 190 is disposed at the end of the outer wall 115 of the cooling unit proximate to the drug storage area 150 of the container 100. The illustrated embodiment also includes a refrigeration unit 700 with an outer wall 740. The refrigeration unit 700 is in thermal contact with the evaporator coil unit 190 disposed in the internal evaporation region 240 of the cooling unit. FIG. 7 illustrates an embodiment of a pharmaceutical storage container 100 that includes a vapor line 130 with a first end 180 and a second end 185. The steam line 130 is attached to the outer surface of the outer wall surrounding the opening 135 of the drying unit at the second end 185. The steam line 130 is attached to the outer surface of the outer wall 115 surrounding the opening 133 of the evaporative cooling unit at the first end 180. The steam line 130 forms an internal gas impervious path between the internal drying area 120 of the drying unit and the internal evaporation area 240 of the cooling unit. In the illustrated embodiment, the steam control unit 140 is attached to the steam line 130. The steam control unit 140 is connected to the controller 170 by a wire connector 145. The illustrated embodiment includes a drug storage unit with an outer wall 151 surrounding a drug storage area 150. The pharmaceutical storage area 150 includes a temperature sensor 159 operatively connected to the controller 170.

  FIG. 7 shows an embodiment of a pharmaceutical storage container 100 that includes a refrigeration unit 700. The refrigeration unit 700 is disposed in the vicinity of the evaporator coil unit 190 located in the internal evaporation region 240 of the cooling unit. As shown in FIG. 7, in embodiments, the refrigeration unit 700 includes one or more walls 740. The size, shape, and position of the wall 740 are set in order to hold one or more ice packs 730 in a predetermined position. In the present embodiment, the size, shape, and position of the wall portion of the refrigeration unit may be set in order to fix one or more ice packs according to the WHO standard in the refrigeration unit. In embodiments, the wall of the refrigeration unit may be made of a thermally conductive material (eg, a thermally conductive metal). In embodiments, the wall of the refrigeration unit may be made of aluminum or copper. In embodiments, the refrigeration unit includes: (i) an opening sized, shaped, and positioned so that a user can reach a metal located inside the refrigeration unit; (ii) the opening A reversibly attachable cover. For example, the cover may include a heat insulating cover arranged and configured to reduce leakage of heat from the refrigeration unit when the cover is in place. According to the cover, the user can reversibly remove the cover as needed, take out one or more refrigeration packs from the refrigeration unit, or replace the refrigeration pack in the refrigeration unit. Embodiments include a temperature sensor operably connected to the controller. FIG. 7 shows an embodiment of a pharmaceutical storage container 100 that includes a refrigeration unit 700. The refrigeration unit 700 has a temperature sensor 710. The temperature sensor 710 is arranged to detect the temperature inside the refrigeration unit 700. In the illustrated embodiment, the temperature sensor 710 is connected to the controller 170 by a wire connector 720. The controller is configured to obtain information (eg, temperature data) from the temperature sensor.

  In embodiments, the refrigeration unit of the pharmaceutical storage container includes a thermally conductive wall. The wall portion has a first surface disposed in proximity to the internal refrigeration region and a second surface disposed at a position in thermal contact with the outer surface of at least one evaporator coil unit. For example, FIG. 7 shows a refrigeration unit 700 that includes a wall 740 made of a thermally conductive metal (eg, aluminum). The wall portion 740 of the refrigeration unit is disposed on the left side of the refrigeration unit in FIG. The wall portion 740 is disposed at a position where it is in thermal contact with the first surface (eg, the right side in FIG. 7) disposed close to the internal refrigeration region and the outer surface of the evaporator coil unit 190. (For example, the left side in FIG. 7). In some embodiments, as FIG. 7 shows, a 1st surface and a 2nd surface are the surfaces which a wall part opposes.

  Embodiments of a pharmaceutical storage container include a drying unit, a heating element, a controller, a cooling unit, a compression system, a steam line, a steam control unit, a thermal control unit, a pharmaceutical storage unit, including. The drying unit has one or more outer walls. The one or more outer walls are sealed together to form a gas impervious barrier around the inner dry region. The one or more outer walls include an opening. The heating element is arranged in the internal drying area. The controller is operatively connected to the heating element. The cooling unit has one or more outer walls. The one or more outer walls are sealed together to form a gas and liquid impervious barrier around the inner evaporation region. The one or more outer walls include an opening. The compression system includes at least one evaporator coil unit disposed in the internal evaporation region of the cooling unit. The compression system is operably connected with the controller. The steam line includes a first end and a second end. The steam line is attached to the outer surface of one or more outer walls that surround the opening of the drying unit at the first end. The steam line is attached to the outer surface of the one or more outer walls that surround the opening of the evaporation unit at the second end. The steam line forms an internal gas impervious path between the internal drying area of the drying unit and the internal evaporation area of the cooling unit. The steam control unit is attached to the steam line. The steam control unit is operably connected to the controller. The thermal control unit is attached to the steam line. The thermal control unit is operably connected to the controller. The drug storage unit includes one or more outer walls that surround a drug storage area. The pharmaceutical storage area includes at least one temperature sensor operably connected to the controller.

  For example, FIG. 8 shows a pharmaceutical storage container 100 that includes a drying unit with an outer wall 320. The outer wall 320 is sealed together to form a gas impervious barrier around the inner dry region 120. The outer wall 320 includes an opening 135. The embodiment shown in FIG. 8 also includes a heating element 127 disposed in the internal drying region 120 and a controller 170 operatively connected to the heating element 12 by a wire connector. The present embodiment includes a cooling unit including an outer wall 115. The outer wall 115 is sealed together to form a gas and liquid impervious barrier around the inner evaporation region 240. The outer wall 115 includes an opening 133. The illustrated embodiment also includes a compression system 160 with an evaporator coil unit 190. The evaporator coil unit 190 is disposed in the internal evaporation region 240 of the cooling unit. The compression system 160 is operatively connected to the controller 170 via a wire connector 165. The illustrated embodiment includes a steam line 130 with a first end 180 and a second end 185. The steam line 130 is attached to the outer surface 320 of the outer wall surrounding the opening 135 of the drying unit at the second end 185. The steam line 130 is attached to the outer surface of the outer wall 115 surrounding the opening 133 of the evaporative cooling unit at the first end 180. The steam line 130 forms a gas-impermeable internal path between the internal drying area 120 of the drying unit and the internal evaporation area 240 of the cooling unit. The illustrated embodiment includes a steam control unit 140 attached to the steam line 130. The steam control unit 140 is operably connected to the controller 170 by a wire connector 145. The embodiment shown in FIG. 8 includes a drug storage unit with an outer wall 151 surrounding a drug storage area 150. The pharmaceutical storage area 150 includes a temperature sensor 159 operatively connected to the controller 170 by a wire connector 157.

  The illustrated embodiment also includes a thermal control unit 800 attached to the steam line 130. The illustrated thermal control unit 800 is attached to the outside of the steam line 130 proximate to the first end 180. The thermal control unit 800 is operatively connected to the controller 170 by a wire connector 145. In embodiments, the thermal control device includes a peltier device. The Peltier element is provided on the cooling surface close to the outer surface of the steam line. For example, the Peltier element may be arranged at a calculated position in the steam line to sufficiently cool the inner surface of the steam line, and may be configured to sufficiently cool the inner surface of the steam line. Thereby, formation of the condensate derived from the evaporating liquid in the vapor pipe line can be promoted, and return of the condensate to the internal evaporation region of the cooling unit by the flow by gravity (gravity flow) can be promoted. In embodiments, the thermal control device includes an evaporator coil unit in thermal contact with the steam line. The evaporator coil unit is attached to a compression system. For example, the evaporator coil unit may be an evaporator coil distinguished from other evaporator coils in the cooling unit, and may be independently controllable by a controller. For example, the evaporator coil unit may be an evaporator coil parallel to other evaporator coils in the cooling unit. For example, the coil unit for the evaporator is disposed at a calculated position in the steam line to sufficiently cool the inner surface of the steam line, and is configured to sufficiently cool the inner surface of the steam line. Good. Thereby, formation of the condensate derived from the evaporating liquid in the vapor pipe line can be promoted, and return of the condensate to the internal evaporation region of the cooling unit by the gravity flow can be promoted. The thermal control unit may be activated or deactivated by a controller, for example, in response to information from a temperature sensor located within or close to the steam line. The thermal control unit may be activated or deactivated by a controller, for example in conjunction with the operation of the heating element for a refill cycle.

  State-of-the-art technology has evolved to the point where there is little difference between hardware, software (eg, high-level computer programs function as hardware specifications), and / or firmware implementations of system aspects. Hardware, software, and / or firmware usage is usually (although not always. In some background situations, the choice of hardware and software can be important), cost This is a design choice corresponding to a trade-off of effectiveness. Depending on the various media, the processes and / or systems and / or other techniques described herein may be (eg, hardware, software (eg, high-level computer programs may serve as hardware specifications). And / or firmware), and the preferred media will vary with the context in which the process and / or system and / or other technologies are deployed. For example, implementers may choose major hardware and / or firmware media if they decide speed and precision are the top priority, or implementers may choose if flexibility is a top priority, An implementation of the main software (eg, a high-level computer program functions as a hardware specification) may be chosen, or alternatively, an implementer may choose hardware, software (eg, a high-level computer program, It functions as a hardware specification.) And / or a combination of firmware may be chosen. Thus, there are multiple possible media in which the processes and / or systems and / or other techniques described herein may be effective, the context in which the media is deployed, and the specifics of the implementer Depending on the particular concern (eg speed, flexibility, or predictability), the media used is selected, so none of the possible media is inherently superior to other media The possible media may vary. The optical aspects of the implementation typically employ optically oriented hardware, software (eg, high-level computer programs function as hardware specifications), and / or firmware. it can.

  In some implementations described herein, logic and similar implementations may include computer programs or other control structures. The electronic circuitry may comprise one or more current paths that are constructed and organized to implement various functions as described herein, for example. In some implementations, one or more media are responsible for device-detectable implementations when holding or transmitting device-detectable commands that can be performed as described herein. It may be configured. In some variations, for example, implementations may use existing software (e.g., by performing reception or transmission of one or more instructions related to one or more operations described herein) (e.g., The high level computer program serves as a hardware specification.) Or may include firmware updates or modifications, or may include gate array hardware or programmable hardware updates or modifications. In some variations, implementations may include special purpose hardware, software (eg, high-level computer programs function as hardware specifications), firmware components, and / or special purpose components. May be included, or a generic component to call may be included. The specification or other implementation may be transmitted by one or more tangible transmission media as described herein, depending on the situation, by packet transmission, or otherwise at various times. It may be transmitted by passing through distributed media.

  An implementation may perform, trigger, emphasize, or perform a special purpose command sequence, that is, cause one or more of virtually all functional actions described herein, It may include circuitry for requesting or otherwise causing. In some variations, operational or other logical things described herein may be expressed and compiled as source child code, and otherwise executable instruction sequences. May be included. In certain background situations, for example, an implementation may be provided, in whole or in part, by source code such as C ++ or other code sequences. In other implementations, source or other code implementations that are commercially available and / or used in the art may be compiled / implemented / translated / converted into a high-level description language (eg, first in a C or C ++ programming language). Implement the described techniques, and then convert the programming language implementation into a logic-synthesizable language implementation, a hardware description language implementation, a hardware design simulation implementation, and / or other similar representation modes.) For example, some or all of the logic representation (eg, a computer programming language implementation) may be part of a Verilog hardware description (eg, Hardware Description Language (HDL) and / or a very high speed integrated circuit hardware description language ( Very High Speed Integrated Circuit Hardware Descriptor Language (VHDL)), or as other circuit configuration models used to create physical implementations with hardware (eg, application specific integrated circuits) Good.

  Some of the subject matter described herein includes application specific integrated circuits (ASICs), field programmable gate arrays (FPGAs), digital signal processors (DSPs). ) Or other integrated format. However, some aspects of the embodiments described herein may be wholly or partially as one or more computer programs (eg, one or more computer systems) running on one or more computers. As one or more computer programs running on), as one or more programs running on one or more processors (eg, as one or more programs running on one or more microprocessors), as firmware, or Can be equally implemented in an integrated circuit as any substantial combination thereof. In addition, information produced by the subject matter described herein can be distributed in various ways, and the illustrated embodiments of the subject matter described herein are actually This applies regardless of the type of media that carries the signal used. For example, media that carry signals are not limited to this, but floppy (registered trademark) disks, hard disk drives, compact discs (CDs), digital video disks (DVDs), digital tapes, computer memories, etc. Recordable type media such as, and digital and / or analog communication media (eg, fiber optic cable, waveguide, wire communication link, wireless communication link (eg, transmitter, receiver, transmission logic, reception logic, etc.), etc. ) May be included.

  The various embodiments described herein include (i) hardware, software (eg, a high-level computer program functions as a hardware specification), firmware, and / or any of these. A wide range of electrical components such as (ii) rigid bodies, springs or twisted bodies, hydraulics, electromagnetic drives, and / or mechanical forces such as any combination thereof Or it can be implemented individually and / or collectively by various types of electromechanical systems with a wide range of components capable of providing mechanical motion. For this reason, the “mechatronics system” used in the present specification is not limited to this, but is a transducer (for example, a drive unit, a motor, a piezoelectric crystal, a micro electro mechanical system (MEMS), etc.). An electrical circuit configuration operably coupled to, an electrical circuit configuration comprising at least one discrete electrical circuit, an electrical circuit configuration comprising at least one integrated circuit, an electrical circuit configuration comprising at least one application specific integrated circuit, a computer program A general-purpose computing device configured by a computer (eg, a general-purpose computer configured by a computer program that at least partially executes the devices and / or processes described herein, or described herein) Device and / or Or a microprocessor configured by a computer program that at least partially executes a process), an electrical circuit configuration forming a memory device (eg, memory (eg, random access memory, flash memory, read-only memory, etc.) Electrical circuit configuration forming communication devices (eg, modems, communication switches, opto-electrical equipment, etc.) and / or optical or other analogs in addition to such electrical circuit configurations Non-electrical analog circuitry (eg, graphene-based circuitry). For example, mechatronic systems include, but are not limited to, private electronic systems, medical devices, and / or communication / computing systems.

  The various aspects described herein can include (i) a wide range of hardware, software (eg, high-level computer programs function as hardware specifications), firmware, and / or Any combination can be implemented individually and / or collectively, and (ii) can be considered to consist of various types of “electrical circuit configurations”. For this reason, the “electric circuit configuration” used in the present specification is not limited thereto, but includes an electric circuit configuration including at least one discrete electric circuit, an electric circuit configuration including at least one integrated circuit, and at least one. An electrical circuit configuration comprising one application specific integrated circuit, a general purpose computing device configured by a computer program (eg configured by a computer program that at least partially executes the devices and / or processes described herein) A general purpose computer, or an electrical circuit configuration that forms a memory device (e.g., a memory (e.g., a memory) (e.g., a microprocessor configured by a computer program that at least partially executes the devices and / or processes described herein). For example, Dam access memory, flash memory, electrical circuitry forming a style) of the lead, such as only memory), and / or the communications device (e.g., including a modem, communications switch, the electrical circuitry forming a light electric appliances, etc.). The subject matter described herein may be implemented in an analog manner, a digital manner, or any combination thereof.

  The subject matter described herein, in some cases, refers to different components that are contained within or otherwise connected to other different components. It should be noted that the structure depicted in this way is merely an example, and in fact, many other structures that achieve similar functionality may be implemented. In a conceptual sense, any organization of components to achieve similar functionality is effectively “associated” so that the desired functionality is achieved. For this reason, any two components in the present specification combined to achieve a particular functionality can be used together to achieve the desired functionality regardless of the structure and intermediate components. Can be considered “related”. Similarly, any two components so related can also be considered “operably connected” or “operably coupled” to each other to achieve the desired functionality. Also, any two components that can be so associated can be considered “operably coupled” to each other to achieve the desired functionality. Examples of operably coupleable include, but are not limited to, physically bondable and / or physically interacting components, and / or wirelessly interactable and / or wirelessly interacting Components that act and / or components that interact and / or can interact with logic.

  The above-mentioned US patents, US patent application publications, US patent applications referenced herein and / or listed in any application data sheet (including but not limited to [insert list]) All foreign patents, foreign patent applications, and non-patent publications are incorporated herein by reference to the extent they do not conflict with the present specification.

  Aspects of the subject matter described herein are listed below with numbers.

1. In some embodiments, the pharmaceutical storage container is
(I) comprising one or more outer walls, (ii) the one or more outer walls being sealed together to form an impermeable barrier around the inner dry region; (iii) the one or more The outer wall of the drying unit comprising an opening;
A heating element disposed inside the internal drying region;
A controller operably attached to the heating element;
(I) comprising one or more outer walls; (ii) the one or more outer walls are integrally sealed to form an impermeable and impermeable barrier around the inner evaporation region; ) The one or more outer walls include a cooling unit comprising an opening;
(I) at least one evaporator coil unit disposed inside the internal evaporation region of the cooling unit; (ii) a compression system operably connected to the controller;
(Ii) comprising a first end and a second end; (ii) attached at an outer surface of the one or more outer walls surrounding the opening of the drying unit at the first end; (iii) the evaporative cooling Attached to the outer surface of the one or more outer walls surrounding the opening of the unit at the second end; (iv) between the internal drying area of the drying unit and the internal evaporation area of the cooling unit An evaporation line forming an impermeable inner passage; and
(I) attached to the evaporation line; (ii) an evaporation control unit operably attached to the controller;
(I) comprising one or more outer walls surrounding the drug storage area; (ii) the drug storage area comprising a drug storage unit including at least one sensor operably connected to the controller.

  2. In the medicine storage container according to one item included in some embodiments, the drying unit includes one unit or more of a desiccant inside the internal drying region.

  3. In the pharmaceutical storage container according to one item included in some embodiments, the drying unit includes a vapor sealed chamber in which an inner region of the evaporation pipe and a vapor include an inner drying region.

  4). In the medicine storage container according to one item included in some embodiments, the drying unit is configured to discharge a gas having a pressure exceeding a predetermined limit from the internal drying region of the drying unit to the outside. A one-way valve unit.

  5. In the medicine storage container according to one item included in some embodiments, the drying unit includes a gas pressure smaller than atmospheric pressure inside the internal drying region.

  6). In the pharmaceutical storage container according to one item included in some embodiments, the drying unit includes a gas pressure of less than 1 Torr inside the internal drying area.

  7). In one embodiment of the pharmaceutical storage container included in some embodiments, the drying unit includes a gas pressure less than 0.1 Torr inside the internal drying area.

  8). In the pharmaceutical storage container according to one item included in some embodiments, the drying unit is (i) disposed inside the inner drying area, and (ii) distributes gas inside the inner drying area. With open cell metal foam arranged for the purpose.

  9. In the pharmaceutical storage container according to one item included in some embodiments, the drying unit is (i) disposed inside the inner drying area, and (ii) distributes gas inside the inner drying area. One or more pipes (pipes) arranged for the purpose.

  10. In one embodiment of the pharmaceutical storage container included in some embodiments, the one or more outer walls of the drying unit include a conductive material.

  11. In the pharmaceutical storage container according to one item included in some embodiments, the heating element disposed inside the internal drying region includes an electric heating element.

  12 In the pharmaceutical storage container according to one item included in some embodiments, the heating element disposed inside the internal drying region includes a heating element having a coil structure.

  13. In the pharmaceutical storage container according to one item included in some embodiments, the heating element disposed inside the internal drying region includes one or more heat conducting elements attached to the heating element.

  14 In the pharmaceutical storage container according to one item included in some embodiments, the controller includes an electric controller.

  15. In the pharmaceutical storage container according to one item included in some embodiments, the controller includes a memory.

  16. In the pharmaceutical storage container according to one item included in some embodiments, the controller controls the operation of the heating element in response to a signal received from at least one temperature sensor inside the pharmaceutical storage area. Including a circuit configured to control.

  17. In the pharmaceutical storage container according to one item included in some embodiments, the controller includes a lookup table.

  18. In one embodiment of the pharmaceutical storage container included in some embodiments, the controller is operably attached to the heating element and the at least one temperature sensor with a wire connector.

  19. In one embodiment of the drug storage container included in some embodiments, the controller is operably attached to the compression system.

  20. In one embodiment of the pharmaceutical storage container included in some embodiments, the controller is operably attached to a power source.

  21. In the medicine storage container according to one item included in some embodiments, the cooling unit includes an upper region disposed next to the opening of the outer wall, and a lower region disposed below the upper region. And an evaporating liquid substantially disposed inside the lower region.

  22. In the medicine storage container according to one item included in some embodiments, the cooling unit includes at least one evaporating liquid inside the internal evaporation region of the evaporative cooling unit.

  23. In the pharmaceutical storage container according to one item included in some embodiments, the cooling unit includes a liquid storage unit connected to at least one surface adjacent to the internal occurrence area.

  24. The pharmaceutical storage container according to one item included in some embodiments, wherein the cooling unit includes one or more heat attached to the at least one evaporator coil unit disposed inside the internal evaporation region. Including a conductive element.

  25. The pharmaceutical storage container according to one item included in some embodiments, wherein the cooling unit is (i) one or more operatively attached to the controller, (ii) inside the internal evaporation region. Temperature sensor.

  26. In the medicine storage container according to one item included in some embodiments, the cooling unit includes a liquid level sensor disposed inside the internal evaporation region.

  27. The pharmaceutical storage container according to one item included in some embodiments, wherein the at least one evaporator coil unit disposed inside the internal evaporation region of the cooling unit is adjacent to the drying unit. Located next to the outer wall of the unit.

  28. In the medicine storage container according to one item included in some embodiments, the at least one evaporator coil unit disposed inside the internal evaporation region of the cooling unit is substantially disposed at a center of the cooling unit. Has been.

  29. In the medicine storage container according to one item included in some embodiments, the at least one evaporator coil unit disposed inside the internal evaporation region of the cooling unit is close to the medicine storage unit. It is arranged next to the outer wall of the cooling unit.

  30. In the pharmaceutical storage container according to one item included in some embodiments, the compression system includes at least one evaporator coil unit disposed inside the internal evaporation region of the cooling unit, a compressor unit, A drying unit and an expansion valve are provided, and the compressor unit, the drying unit, and the expansion valve are disposed outside the internal evaporation region of the cooling unit.

  31. The pharmaceutical storage container of one item included in some embodiments, wherein the compression system is configured to switch the compression system on and off in response to a signal received from the controller. Is provided.

  32. In the medicine storage container according to one item included in some embodiments, the evaporation pipe conducts heat conduction between the at least one outer wall of the drying unit and the at least one outer wall of the cooling unit. Provide a generally tubular structure of sufficient length and diameter to constrain.

  33. In the pharmaceutical storage container according to one item included in some embodiments, the evaporation pipe is configured to minimize conduction of thermal energy between the drying unit and the cooling unit.

  34. In the medicine storage container according to one item included in some embodiments, the evaporation pipe includes one or more heat conducting elements attached to an outer surface of the evaporation pipe.

  35. In the medicine storage container according to one item included in some embodiments, the evaporation pipe includes an impermeable wall of the evaporation pipe, the first end of the evaporation pipe, and the drying unit. And an impermeable seal between the second end of the evaporation line and the cooling unit.

  36. In the medicine storage container according to one item included in some embodiments, the evaporation pipe is (i) destructible from the outside crossing the internal passage of the evaporation pipe, and (ii) the evaporation pipe A seal configured to prevent gas flow through the internal passage of the path;

  37. In the medicine storage container according to one item included in some embodiments, the evaporation pipe is (i) disposed inside the evaporation pipe and next to the first end, and (ii) the controller. A first temperature sensor operably attached to the controller, and (i) a second temperature sensor disposed inside the evaporation line next to the second end and ii) operably attached to the controller And comprising.

  38. In the medicine storage container according to one item included in some embodiments, the evaporation control unit includes: (i) the evaporation between the internal drying area of the drying unit and the internal evaporation area of the cooling unit. (Ii) comprising at least one valve configured to operate in response to a signal received from the controller; and configured to control gas movement through the internal passage of a conduit.

  39. In the medicine storage container according to one item included in some embodiments, the evaporation control unit includes a temperature sensor.

  40. In the medicine storage container according to one item included in some embodiments, the evaporation control unit includes a pressure sensor.

  41. In the medicine storage container according to one item included in some embodiments, the medicine storage unit is (i) next to the medicine storage area, and (ii) thermally conductive at a desired temperature of the medicine storage area. With one or more walls made to be.

  42. In the medicine storage container according to one item included in some embodiments, the medicine storage unit is (i) disposed on the outer wall next to an uppermost area of the medicine storage area, and (ii) a user makes the medicine storage A hinge lid configured to be accessible to the storage area.

  43. In the pharmaceutical storage container according to one item included in some embodiments, the at least one temperature sensor of the pharmaceutical storage unit is arranged to detect a temperature inside the pharmaceutical storage region.

  44. In the pharmaceutical storage container according to one item included in some embodiments, the at least one temperature sensor of the pharmaceutical storage unit is an electrical temperature sensor.

  45. The medicine storage container according to one item included in some embodiments further includes one or more heat insulating materials surrounding the cooling unit and the medicine storage unit.

  46. The medicine storage container according to one item included in some embodiments is further disposed directly below the medicine storage container, and (ii) substantially surrounds at least one region of the compressor stem and the controller 1 A base unit with more than one wall is provided.

  47. The medicine storage container according to one item included in some embodiments is further disposed between an outer surface of the one or more outer walls of the drying unit and an outer surface of the one or more outer walls of the cooling unit. Including gaps.

  48. The medicine storage container according to one item included in some embodiments is further disposed between an outer surface of the one or more outer walls of the drying unit and an outer surface of the one or more outer walls of the cooling unit. And (ii) a blower of a size, shape, and arrangement that is attached to the outer surface of the one or more outer walls of the drying unit, and (ii) circulates air inside the gap.

49. In some embodiments, the pharmaceutical storage container is
(I) comprising one or more outer walls, (ii) the one or more outer walls being sealed together to form an impermeable barrier around the inner dry region; (iii) the one or more The outer wall of the drying unit comprising an opening;
A heating element disposed inside the internal drying region;
A controller operably attached to the heating element;
(I) comprising one or more outer walls; (ii) the one or more outer walls are integrally sealed to form an impermeable and impermeable barrier around the inner evaporation region; ) The one or more outer walls include a cooling unit comprising an opening;
(I) at least one evaporator coil unit disposed inside the internal evaporation region of the cooling unit; (ii) a compression system operably connected to the controller;
(I) comprising one or more outer walls; (ii) a refrigeration unit in thermal contact with the at least one evaporator coil unit disposed inside the internal evaporation region of the cooling unit;
(Ii) comprising a first end and a second end; (ii) attached to an outer surface of the one or more outer walls surrounding the opening of the drying unit at the second end; (iii) the evaporative cooling Attached to the outer surface of the one or more outer walls surrounding the opening of the unit at the first end; (iv) between the internal drying area of the drying unit and the internal evaporation area of the cooling unit An evaporation line forming an impermeable inner passage; and
(I) attached to the evaporation line; (ii) an evaporation control unit operably attached to the controller;
(I) comprising one or more outer walls surrounding the drug storage area; (ii) the drug storage area comprising a drug storage unit including at least one sensor operably connected to the controller.

  50. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the drying unit includes one or more desiccants inside the internal drying region.

  51. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the drying unit includes a vapor-sealed chamber that includes an internal drying region that communicates with an internal region of the evaporation conduit.

  52. 49. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the drying unit is configured to discharge a gas having a pressure exceeding a predetermined limit from the internal drying region of the drying unit to the outside. A one-way valve unit.

  53. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the drying unit includes a gas pressure smaller than atmospheric pressure inside the internal drying region.

  54. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the drying unit includes a gas pressure of less than 1 Torr inside the internal drying area.

  55. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the drying unit includes a gas pressure of less than 0.1 Torr inside the internal drying area.

  56. 49. The medicine storage container according to item 49, which is included in some embodiments, wherein the drying unit is (i) disposed inside the internal drying area, and (ii) can distribute gas inside the internal drying area. With open cell metal foam arranged in such a manner.

  57. 49. The medicine storage container according to item 49, which is included in some embodiments, wherein the drying unit is (i) disposed inside the internal drying area, and (ii) can distribute gas inside the internal drying area. One or more pipes (pipes) arranged as described above are provided.

  58. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the one or more outer walls of the drying unit include a conductive material.

  59. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the heating element disposed inside the internal drying region includes an electric heating element.

  60. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the heating element disposed inside the internal drying region includes a heating element having a coil structure.

  61. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the heating element disposed inside the internal drying region includes one or more heat conducting elements attached to the heating element.

  62. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the controller includes an electric controller.

  63. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, the controller includes a memory.

  64. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the controller controls the operation of the heating element in response to a signal received from at least one temperature sensor inside the pharmaceutical storage area. Including a circuit configured to control.

  65. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, the controller includes a lookup table.

  66. 50. The pharmaceutical storage container of item 49, included in some embodiments, wherein the controller is operably attached to the heating element and the at least one temperature sensor with a wire connector.

  67. 50. The pharmaceutical storage container of item 49, included in some embodiments, wherein the controller is operably attached to the compression system.

  68. 50. The pharmaceutical storage container of item 49 included in some embodiments, wherein the controller is operably attached to a power source.

  69. 49. The medicine storage container according to item 49, which is included in some embodiments, wherein the cooling unit includes an upper region disposed next to the opening of the outer wall, and a lower region disposed below the upper region. And an evaporating liquid substantially disposed inside the lower region.

  70. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the cooling unit includes at least one evaporating liquid inside the internal evaporation region of the evaporative cooling unit.

  71. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the cooling unit includes a liquid storage unit connected to at least one surface next to the internal origin area.

  72. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the cooling unit includes one or more heat attached to the at least one evaporator coil unit disposed inside the internal evaporation region. Including a conductive element.

  73. 50. The pharmaceutical storage container of item 49, included in some embodiments, wherein the cooling unit is (i) one or more operatively attached to the controller, (ii) inside the internal evaporation region. Temperature sensor.

  74. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the cooling unit includes a liquid level sensor disposed inside the internal evaporation region.

  75. 49. The medicine storage container according to item 49, which is included in some embodiments, wherein the at least one evaporator coil unit disposed inside the internal evaporation region of the cooling unit includes one or more of the refrigeration units. Located next to the wall.

  76. 49. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the compression system includes at least one evaporator coil unit disposed inside the internal evaporation region of the cooling unit, a compressor unit, A condensation unit and an expansion valve are provided, and the compressor unit, the drying unit, and the expansion valve are disposed outside the internal evaporation region of the cooling unit.

  77. 50. The pharmaceutical storage container of item 49, included in some embodiments, wherein the compression system is configured to switch the compression system on and off in response to a signal received from the controller. Is provided.

  78. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the refrigeration unit comprises one or more walls of dimensions, shape and arrangement that hold the one or more ice packs in place.

  79. 49. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the refrigeration unit is open to a size, shape, and arrangement that allows a user to access materials inside the refrigeration unit, and can be switched back to the opening A lid attached to the.

  80. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the refrigeration unit includes a temperature sensor operably attached to the controller.

  81. 49. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the refrigeration unit includes: (i) a first side surface disposed next to an internal refrigeration region; and (ii) the at least one evaporator coil unit. A thermally conductive wall having a second side surface arranged to be in thermal contact with the outer surface of the substrate.

  82. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the evaporation pipe conducts heat transfer between the at least one outer wall of the drying unit and the at least one outer wall of the cooling unit. Provide a generally tubular structure of sufficient length and diameter to constrain.

  83. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the evaporation conduit is configured to minimize conduction of thermal energy between the drying unit and the cooling unit.

  84. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the evaporation conduit includes one or more heat conducting elements attached to an outer surface of the evaporation conduit.

  85. 49. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the evaporation conduit includes an impermeable wall of the evaporation conduit, the first end of the evaporation conduit, and the drying unit. And an impermeable seal between the second end of the evaporation line and the cooling unit.

  86. 49. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the evaporation pipe is (i) destructible from the outside that intersects the internal passage of the evaporation pipe, and (ii) the evaporation pipe A seal configured to prevent gas flow through the internal passage of the path;

  87. 49. The medicine storage container according to item 49, which is included in some embodiments, wherein the evaporation conduit is (i) disposed inside the evaporation conduit and next to the first end, and (ii) the controller. A first temperature sensor operably attached to the controller, and (i) a second temperature sensor disposed inside the evaporation line next to the second end and ii) operably attached to the controller And comprising.

  88. 49. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the evaporation control unit includes: (i) the evaporation between the internal drying region of the drying unit and the internal evaporation region of the cooling unit. (Ii) comprising at least one valve configured to operate in response to a signal received from the controller; and configured to control gas movement through the internal passage of a conduit.

  89. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the evaporation control unit includes a temperature sensor.

  90. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the evaporation control unit includes a pressure sensor.

  91. 49. The drug storage container according to item 49, which is included in some embodiments, wherein the drug storage unit is thermally conductive at (i) next to the drug storage area, and (ii) at a gas temperature in the drug storage area. It has one or more walls that are made to be.

  92. 49. The drug storage container according to item 49, which is included in some embodiments, wherein the drug storage unit is (i) disposed on the outer wall next to an uppermost area of the drug storage area, and (ii) a user makes the drug storage A hinge lid configured to be accessible to the storage area.

  93. 50. The drug storage container according to item 49, which is included in some embodiments, wherein the at least one temperature sensor of the drug storage unit is arranged to detect a temperature inside the drug storage area.

  94. 50. The pharmaceutical storage container according to item 49, which is included in some embodiments, wherein the at least one temperature sensor of the pharmaceutical storage unit is an electrical temperature sensor.

  95. 49. The medicine storage container according to 49, which is included in some embodiments, further includes one or more heat insulating materials surrounding the cooling unit, the medicine storage unit, and the refrigeration unit.

  96. 49. The drug storage container according to item 49, which is included in some embodiments, is further disposed directly below the drug storage container, and (ii) substantially surrounds at least one region of the compression system and the controller. A base unit with more than one wall is provided.

  97. 49. The pharmaceutical storage container according to item 49, which is included in some embodiments, is further disposed between an outer surface of the one or more outer walls of the drying unit and an outer surface of the one or more outer walls of the cooling unit. Including gaps.

  98. 49. The pharmaceutical storage container according to item 49, which is included in some embodiments, is further disposed between an outer surface of the one or more outer walls of the drying unit and an outer surface of the one or more outer walls of the cooling unit. And (ii) a blower of a size, shape, and arrangement that is attached to the outer surface of the one or more outer walls of the drying unit, and (ii) circulates air inside the gap.

99. In some embodiments, the pharmaceutical storage container is
(I) comprising one or more outer walls, (ii) the one or more outer walls being sealed together to form an impermeable barrier around the inner dry region; (iii) the one or more The outer wall of the drying unit comprising an opening;
A heating element disposed inside the internal drying region;
A controller operably attached to the heating element;
(I) comprising one or more outer walls; (ii) the one or more outer walls are integrally sealed to form an impermeable and impermeable barrier around the inner evaporation region; ) The one or more outer walls include a cooling unit comprising an opening;
(I) at least one evaporator coil unit disposed inside the internal evaporation region of the cooling unit; (ii) a compression system operably connected to the controller;
(Ii) comprising a first end and a second end; (ii) attached to an outer surface of the one or more outer walls surrounding the opening of the drying unit at the second end; (iii) the evaporative cooling Attached to the outer surface of the one or more outer walls surrounding the opening of the unit at the first end; (iv) between the internal drying area of the drying unit and the internal evaporation area of the cooling unit An evaporation line forming an impermeable inner passage; and
(I) attached to the evaporation line; (ii) an evaporation control unit operably attached to the controller;
(I) a thermal control unit attached to the evaporation line; and (ii) a thermal control unit operably attached to the controller;
(I) comprising one or more outer walls surrounding the drug storage area, (ii) the drug storage area comprising a drug storage unit comprising at least one sensor operably connected to the controller.

  100. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the drying unit includes one or more desiccants inside the internal drying region.

  101. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the drying unit comprises a vapor sealed chamber comprising an internal drying region in communication with an internal region of the evaporation conduit.

  102. 99. The drug storage container according to item 99, which is included in some embodiments, wherein the drying unit is configured to discharge a gas having a pressure exceeding a predetermined limit from the internal drying region of the drying unit to the outside. A one-way valve unit.

  103. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the drying unit includes a gas pressure smaller than atmospheric pressure inside the internal drying area.

  104. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the drying unit includes a gas pressure less than 1 Torr inside the internal drying area.

  105. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the drying unit includes a gas pressure less than 0.1 Torr inside the internal drying area.

  106. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the drying unit is (i) disposed inside the internal drying region, and (ii) disposed up to a distribution gas inside the internal drying region. Provided open cell metal foam.

  107. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the drying unit is (i) disposed inside the internal drying region, and (ii) disposed up to a distribution gas inside the internal drying region. Provided with one or more pipes.

  108. 100. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the one or more outer walls of the drying unit include a conductive material.

  109. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the heating element disposed inside the internal drying region includes an electric heating element.

  110. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the heating element disposed inside the internal drying region includes a heating element having a coil structure.

  111. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the heating element disposed inside the internal drying region includes one or more heat conducting elements attached to the heating element.

  112. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the controller includes an electrical controller.

  113. 100. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the controller includes a memory.

  114. 99. The drug storage container according to item 99, which is included in some embodiments, wherein the controller controls the operation of the heating element in response to a signal received from at least one temperature sensor inside the drug storage area. Including a circuit configured to control.

  115. 100. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the controller includes a lookup table.

  116. 100. The pharmaceutical storage container of item 99, included in some embodiments, wherein the controller is operably attached to the heating element and the at least one temperature sensor with a wire connector.

  117. 99. The pharmaceutical storage container of item 99, included in some embodiments, wherein the controller is operably attached to the compression system.

  118. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the controller is operably attached to a power source.

  119. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the cooling unit includes an upper region disposed next to the opening of the outer wall, and a lower region disposed below the upper region. And an evaporating liquid substantially disposed inside the lower region.

  120. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the cooling unit includes at least one evaporative liquid inside the internal evaporation region of the evaporative cooling unit.

  121. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the cooling unit includes a liquid storage unit connected to at least one surface next to the internal origin area.

  122. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the cooling unit includes one or more heat attached to the at least one evaporator coil unit disposed inside the internal evaporation region. Including a conductive element.

  123. 99. The pharmaceutical storage container of item 99, included in some embodiments, wherein the cooling unit is (i) one or more operably attached to the controller, (ii) inside the internal evaporation region. Temperature sensor.

  124. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the cooling unit includes a liquid level sensor disposed inside the internal evaporation region.

  125. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the at least one evaporator coil unit disposed inside the internal evaporation region of the cooling unit is adjacent to the drying unit. Located next to the outer wall of the unit.

  126. 99. The medicine storage container according to item 99, which is included in some embodiments, wherein the at least one evaporator coil unit disposed inside the internal evaporation region of the cooling unit is disposed substantially at the center of the cooling unit. Has been.

  127. 99. The medicine storage container according to item 99, which is included in some embodiments, wherein the at least one evaporator coil unit disposed inside the internal evaporation region of the cooling unit is adjacent to the medicine storage unit. It is arranged next to the outer wall of the cooling unit.

  128. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the compression system includes at least one evaporator coil unit disposed inside the internal evaporation region of the cooling unit, a compressor unit, A drying unit and an expansion valve are provided, and the compressor unit, the drying unit, and the expansion valve are disposed outside the internal evaporation region of the cooling unit.

  129. 99. The pharmaceutical storage container of item 99, included in some embodiments, wherein the compression system is configured to switch the compression system on and off in response to a signal received from the controller. Is provided.

  130. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the evaporation conduit conducts heat transfer between the at least one outer wall of the drying unit and the at least one outer wall of the cooling unit. Provide a generally tubular structure of sufficient length and diameter to constrain.

  131. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the evaporation conduit is configured to minimize conduction of thermal energy between the drying unit and the cooling unit.

  132. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the evaporation conduit includes one or more heat conducting elements attached to an outer surface of the evaporation conduit.

  133. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the evaporation conduit includes an impermeable wall of the evaporation conduit, the first end of the evaporation conduit, and the drying unit. And an impermeable seal between the second end of the evaporation line and the cooling unit.

  134. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the evaporation pipe is (i) destructible from the outside that intersects the internal passage of the evaporation pipe, and (ii) the evaporation pipe A seal configured to prevent gas flow through the internal passage of the passage;

  135. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the evaporation conduit is (i) disposed inside the evaporation conduit and next to the first end, and (ii) the controller. A first temperature sensor operably attached to the controller, and (i) a second temperature sensor disposed inside the evaporation line next to the second end and ii) operably attached to the controller And comprising.

  136. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the evaporation control unit includes: (i) the evaporation between the internal drying area of the drying unit and the internal evaporation area of the cooling unit. (Ii) comprising at least one valve configured to operate in response to a signal received from the controller; and configured to control gas movement through the internal passage of a conduit.

  137. 99. The medicine storage container according to item 99, which is included in some embodiments, wherein the evaporation control unit includes a temperature sensor.

  138. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the evaporation control unit includes a pressure sensor.

  139. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the thermal control unit includes a Peltier device disposed on a cooling surface adjacent to an outer surface of the evaporation pipe.

  140. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, wherein the thermal control unit (i) is in thermal contact with the cooling line and (ii) for an evaporator attached to the compression system. A coil unit is provided.

  141. 99. The drug storage container according to 99, which is included in some embodiments, wherein the drug storage unit is (i) next to the drug storage area, and (ii) thermally conductive at a gas temperature of the drug storage area. It has one or more walls that are made to be.

  142. 99. The drug storage container according to item 99, which is included in some embodiments, wherein the drug storage unit is (i) arranged on the outer wall next to the uppermost area of the drug storage area, and (ii) A hinge lid configured to be accessible to the storage area.

  143. 99. The drug storage container according to item 99, which is included in some embodiments, wherein the at least one temperature sensor of the drug storage unit is arranged to detect a temperature inside the drug storage area.

  144. 99. The drug storage container according to item 99, which is included in some embodiments, wherein the at least one temperature sensor of the drug storage unit is an electrical temperature sensor.

  145. 99. The drug storage container according to item 99, which is included in some embodiments, further includes one or more segments of heat insulating material surrounding the cooling unit and the drug storage unit.

  146. 99. The drug storage container according to item 99, which is included in some embodiments, is further disposed immediately below the drug storage container, and (ii) substantially surrounds at least one region of the compressor stem and the controller 1 A base unit with more than one wall is provided.

  147. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, is further disposed between an outer surface of the one or more outer walls of the drying unit and an outer surface of the one or more outer walls of the cooling unit. Including gaps.

  148. 99. The pharmaceutical storage container according to item 99, which is included in some embodiments, is further disposed between an outer surface of the one or more outer walls of the drying unit and an outer surface of the one or more outer walls of the cooling unit. And (ii) a blower of a size, shape, and arrangement that is attached to the outer surface of the one or more outer walls of the drying unit, and (ii) circulates air inside the gap.

  Various aspects and embodiments have been disclosed herein, but other aspects and embodiments will be apparent to those skilled in the art. The various aspects and embodiments disclosed herein are for purposes of illustration and are not intended to be limiting, with the true scope and spirit indicated by the appended claims.

It is an outline of a medicine storage container. It is an outline of a medicine storage container. It is an outline of a medicine storage container. It is an outline of a medicine storage container. It is an outline of a medicine storage container. It is an outline of a medicine storage container. It is an outline of a medicine storage container. It is an outline of a medicine storage container.

Claims (43)

A medicine storage container,
A drying unit;
A heating element;
A controller;
A cooling unit;
A compression system;
A steam line;
A steam control unit;
A pharmaceutical storage unit,
The drying unit comprises one or more outer walls;
The one or more outer walls of the drying unit are sealed together to form an impermeable barrier around the inner drying area;
The one or more outer walls of the drying unit comprise openings;
The heating element is disposed in the internal drying region;
The controller is operably attached to the heating element;
The cooling unit comprises one or more outer walls;
The one or more outer walls of the cooling unit are hermetically sealed to form an impermeable and impermeable barrier around the internal evaporation region;
The one or more outer walls of the cooling unit comprise openings;
The compression system comprises at least one evaporator coil unit disposed in the internal drying region of the cooling unit;
The compression system is operatively connected to the controller;
The steam line has a first end and a second end;
The steam line is attached to an outer surface of the one or more outer walls surrounding the opening of the drying unit at the first end;
The steam line is attached to an outer surface of the one or more outer walls surrounding the opening of the evaporative cooling unit at the second end;
The steam line forms an air-impermeable internal passage between the internal drying region of the drying unit and the internal evaporation region of the cooling unit,
The steam control unit is attached to the steam line;
The steam control unit is operably attached to the controller;
The drug storage unit comprises one or more outer walls surrounding a drug storage area;
The drug storage container, wherein the drug storage area includes at least one temperature sensor operably attached to the controller.   The medicine storage container according to claim 1, wherein the drying unit has a gas pressure lower than atmospheric pressure in the internal drying region. The cooling unit includes an upper region, a lower region, and an evaporating liquid,
The upper region is adjacent to the opening of the outer wall of the cooling unit within the outer wall of the cooling unit;
The lower region is located below the upper region;
The pharmaceutical storage container according to claim 1, wherein the evaporable liquid is substantially located in the lower region.   The medicine storage container according to claim 1, wherein the cooling unit includes a liquid storage unit connected to at least one surface adjacent to the internal evaporation region. The cooling unit includes one or more temperature sensors in the internal evaporation region,
The pharmaceutical storage container of claim 1, wherein the one or more temperature sensors are operably attached to the controller.   The medicine storage container according to claim 1, wherein the cooling unit includes a liquid level sensor disposed in the internal evaporation region.   The at least one evaporator coil unit disposed in the internal evaporation region of the cooling unit is adjacent to the outer wall of the cooling unit adjacent to the drying unit. Pharmaceutical storage container.   The pharmaceutical storage container according to claim 1, wherein the at least one evaporator coil unit disposed in the internal evaporation region of the cooling unit is positioned substantially at the center of the cooling unit.   The medicine storage container according to claim 1, wherein the compression system includes a switch configured to switch ON and OFF of the compression system according to a signal received from the controller. The steam line is
An impermeable wall of the steam line;
An impervious seal between the first end of the steam line and the drying unit;
The medicine storage container according to claim 1, further comprising an air-impermeable sealing material between the second end of the steam line and the cooling unit. The steam line is
It comprises a sealable material that can be broken from the outside, passing through the internal passage of the steam line,
2. The pharmaceutical storage container according to claim 1, wherein the sealing material is configured to prevent a gas from flowing through the internal passage of the vapor pipe line. The steam line is
A first temperature sensor adjacent to the first end in the steam line;
A second temperature sensor adjacent to the second end in the steam line,
The first temperature sensor is operably attached to the controller;
The medicine storage container according to claim 1, wherein the second temperature sensor is operably attached to the controller.   The pharmaceutical storage container according to claim 1, further comprising one or more insulating portions surrounding the cooling unit and the pharmaceutical storage unit.   The medicine storage container according to claim 1, wherein a gap is provided between an outer surface of the one or more outer walls of the drying unit and an outer surface of the one or more outer walls of the cooling unit. . A medicine storage container,
A drying unit;
A heating element;
A controller;
A cooling unit;
A compression system;
A refrigeration unit,
A steam line;
A steam control unit;
A pharmaceutical storage unit,
The drying unit comprises one or more outer walls;
The one or more outer walls of the drying unit are integrally sealed to form an impermeable barrier around the inner drying area;
The one or more outer walls of the drying unit comprise openings;
The heating element is disposed in the internal drying region;
The controller is attached to the heating element;
The cooling unit comprises one or more outer walls;
The one or more outer walls of the cooling unit are hermetically sealed to form an impermeable and liquid impermeable barrier around the internal evaporation region;
The one or more outer walls of the cooling unit comprise openings;
The compression system comprises at least one evaporator coil unit disposed in the internal evaporation region of the cooling unit;
The compression system is operatively connected to the controller;
The refrigeration unit comprises one or more walls;
The refrigeration unit is in thermal contact with the at least one evaporator coil unit disposed in the internal evaporation region of the cooling unit;
The steam line has a first end and a second end;
The steam line is attached to an outer surface of the one or more outer walls surrounding the opening of the drying unit at the second end;
The steam line is attached to an outer surface of the one or more outer walls surrounding the opening of the cooling unit at the first end;
The steam line forms an air-impermeable internal passage between the internal drying region of the drying unit and the internal evaporation region of the cooling unit,
The steam control unit is attached to the steam line;
The steam control unit is operably attached to the controller;
The drug storage unit comprises one or more outer walls surrounding a drug storage area;
The drug storage container, wherein the drug storage area includes at least one temperature sensor operably attached to the controller.   The medicine storage container according to claim 15, wherein the drying unit has a gas pressure lower than atmospheric pressure in the internal drying region. The cooling unit includes an upper region, a lower region, and an evaporating liquid,
The upper region is adjacent to the opening in the outer wall of the cooling unit;
The lower region is located below the upper region;
16. The pharmaceutical storage container according to claim 15, wherein the evaporable liquid is located substantially in the lower region.   The medicine storage container according to claim 15, wherein the cooling unit includes a liquid storage unit connected to at least one surface adjacent to the internal evaporation region. The cooling unit comprises one or more temperature sensors in the internal evaporation region;
16. The pharmaceutical storage container of claim 15, wherein the one or more temperature sensors are operably attached to the controller.   The medicine storage container according to claim 15, wherein the cooling unit includes a liquid level sensor disposed in the internal evaporation region. The compression system includes:
At least one coil unit for the evaporator;
A compression unit;
A condensing unit;
An expansion valve,
The at least one evaporator coil unit is disposed in the internal evaporation region of the cooling unit;
The medicine storage container according to claim 15, wherein the compression unit, the condensing unit, and the expansion valve are arranged outside the internal evaporation region of the cooling unit.   The medicine storage container according to claim 15, wherein the compression system includes a switch configured to switch ON and OFF of the compression system according to a signal received from the controller.   The medicine storage container according to claim 15, wherein the refrigeration unit includes a temperature sensor operably attached to the controller. The refrigeration unit includes a heat conductive wall,
The heat conductive wall has a first side surface adjacent to an internal refrigeration region, and a second side surface disposed so as to be in thermal contact with an external surface of the at least one evaporator coil unit. The pharmaceutical storage container according to claim 15. The steam line is
An impermeable wall of the steam line;
An impervious seal between the first end of the steam line and the drying unit;
16. The medicine storage container according to claim 15, further comprising an air-impermeable sealing material between the second end of the steam line and the cooling unit. The steam line includes a sealable material that can be broken from the outside through the internal passage of the steam line.
16. The medicine storage container according to claim 15, wherein the sealing material is configured to prevent a gas from flowing through the internal passage of the vapor pipe line. The steam line is
A first temperature sensor disposed adjacent to the first end in the steam line;
A second temperature sensor disposed adjacent to the second end in the steam line;
The first temperature sensor is operably attached to the controller;
The medicine storage container according to claim 15, wherein the second temperature sensor is operably attached to the controller. The medicine storage container according to claim 15, further comprising one or more insulating portions surrounding the cooling unit between the medicine storage unit and the refrigeration unit.   16. The medicine storage container according to claim 15, wherein a gap is provided between an outer surface of the one or more outer walls of the drying unit and an outer surface of the outer wall of the cooling unit. A medicine storage container,
A drying unit;
A heating element;
A controller;
A cooling unit;
A compression system;
A steam line;
A steam control unit;
A thermal control unit;
A pharmaceutical storage unit,
The drying unit comprises one or more outer walls;
The one or more outer walls of the drying unit are integrally sealed to form an impermeable barrier around the inner drying area;
The one or more outer walls of the drying unit comprise openings;
The heating element is disposed in the internal drying region;
The controller is attached to the heating element;
The cooling unit comprises one or more outer walls;
The one or more outer walls of the cooling unit are hermetically sealed to form an impermeable and impermeable barrier around the internal evaporation region;
The one or more outer walls of the cooling unit comprise openings;
The compression system comprises at least one evaporator coil unit disposed in the internal evaporation region of the cooling unit;
The compression system is operably attached to the controller;
The steam line has a first end and a second end;
The steam line is attached to an outer surface of the one or more outer walls surrounding the opening of the drying unit at the second end;
The steam line is attached to an outer surface of the one or more outer walls surrounding the opening of the cooling unit at the first end;
The steam line forms an air-impermeable internal passage between the internal drying region of the drying unit and the internal evaporation region of the cooling unit,
The steam control unit is attached to the steam line;
The steam control unit is operably attached to the controller;
The thermal control unit is attached to the steam line;
The thermal control unit is operably attached to the controller;
The drug storage unit comprises one or more outer walls surrounding a drug storage area;
The drug storage container, wherein the drug storage area includes at least one temperature sensor operably connected to the controller.   The pharmaceutical storage container according to claim 30, wherein the drying unit has a gas pressure lower than atmospheric pressure in the internal drying region. The cooling unit includes an upper region, a lower region, and an evaporable liquid.
The upper region is adjacent to the opening of the outer wall of the cooling unit;
The lower region is located below the upper region;
31. A pharmaceutical storage container according to claim 30, wherein the evaporable liquid is located substantially in the lower region.   The medicine storage container according to claim 30, wherein the cooling unit includes a liquid storage unit connected to at least one surface adjacent to the internal evaporation region. The cooling unit comprises one or more temperature sensors in the internal evaporation region;
31. The pharmaceutical storage container of claim 30, wherein the one or more temperature sensors are operably attached to the controller.   The medicine storage container according to claim 30, wherein the cooling unit includes a liquid level sensor disposed in the internal evaporation region. The compression system includes:
At least one evaporator coil unit disposed in the internal evaporation region of the cooling unit;
A compression unit;
A condensing unit;
An expansion valve,
The medicine storage container according to claim 30, wherein the compression unit, the condensing unit, and the expansion valve are disposed outside the internal evaporation region of the cooling unit.   The medicine storage container according to claim 30, wherein the compression system includes a switch for switching ON and OFF of the compression system in accordance with a signal received from the controller. The steam line is
An impermeable wall of the steam line;
An impervious seal between the first end of the steam line and the drying unit;
31. The pharmaceutical storage container according to claim 30, further comprising an air-impermeable sealing material between the second end of the vapor line and the cooling unit. The steam line includes a sealable material that can be broken from the outside, passing through the internal passage of the steam line,
31. The pharmaceutical storage container according to claim 30, wherein the sealing material is configured to prevent gas from flowing through the internal passage of the vapor conduit. The steam line is
A first temperature sensor adjacent to the first end in the steam line;
A second temperature sensor adjacent to the second end in the steam line;
The first temperature sensor is attached to the controller;
The medicine storage container according to claim 30, wherein the second temperature sensor is operably attached to the controller.   The medicine storage container according to claim 30, wherein the thermal control unit includes a Peltier device disposed on a cooling surface adjacent to an outer surface of the steam line. The thermal control unit includes an evaporator coil unit that is in thermal contact with the steam line,
The pharmaceutical storage container according to claim 30, wherein the evaporator coil unit is attached to the compression system.   31. The pharmaceutical storage container according to claim 30, wherein there is a gap between an outer surface of the one or more outer walls of the drying unit and an outer surface of the one or more outer walls of the cooling unit.

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