JP2017520537A5 - - Google Patents
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- JP2017520537A5 JP2017520537A5 JP2016571044A JP2016571044A JP2017520537A5 JP 2017520537 A5 JP2017520537 A5 JP 2017520537A5 JP 2016571044 A JP2016571044 A JP 2016571044A JP 2016571044 A JP2016571044 A JP 2016571044A JP 2017520537 A5 JP2017520537 A5 JP 2017520537A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- pth
- msc
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- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102000003982 Parathyroid hormone Human genes 0.000 claims description 50
- 108090000445 Parathyroid hormone Proteins 0.000 claims description 50
- 239000000199 parathyroid hormone Substances 0.000 claims description 50
- 229960001319 parathyroid hormone Drugs 0.000 claims description 50
- 210000002901 mesenchymal stem cell Anatomy 0.000 claims description 49
- 238000000034 method Methods 0.000 claims description 36
- 238000010253 intravenous injection Methods 0.000 claims description 10
- 238000010254 subcutaneous injection Methods 0.000 claims description 10
- 239000007929 subcutaneous injection Substances 0.000 claims description 10
- 208000001132 Osteoporosis Diseases 0.000 claims description 9
- 210000000988 bone and bone Anatomy 0.000 claims description 8
- 102000004169 proteins and genes Human genes 0.000 claims description 8
- 108090000623 proteins and genes Proteins 0.000 claims description 8
- 230000037182 bone density Effects 0.000 claims description 6
- 102100022464 5'-nucleotidase Human genes 0.000 claims description 5
- 102100032912 CD44 antigen Human genes 0.000 claims description 5
- 101000678236 Homo sapiens 5'-nucleotidase Proteins 0.000 claims description 5
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims description 5
- 101000935043 Homo sapiens Integrin beta-1 Proteins 0.000 claims description 5
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims description 5
- 102100025304 Integrin beta-1 Human genes 0.000 claims description 5
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims description 5
- 210000000577 adipose tissue Anatomy 0.000 claims description 5
- 210000001185 bone marrow Anatomy 0.000 claims description 5
- 210000004271 bone marrow stromal cell Anatomy 0.000 claims description 4
- 210000004027 cell Anatomy 0.000 claims description 4
- 108010049931 Bone Morphogenetic Protein 2 Proteins 0.000 claims description 3
- 108010049974 Bone Morphogenetic Protein 6 Proteins 0.000 claims description 3
- 102100024506 Bone morphogenetic protein 2 Human genes 0.000 claims description 3
- 102100022525 Bone morphogenetic protein 6 Human genes 0.000 claims description 3
- 101000958041 Homo sapiens Musculin Proteins 0.000 claims description 3
- 206010041541 Spinal compression fracture Diseases 0.000 claims description 3
- 102000046949 human MSC Human genes 0.000 claims description 3
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims description 2
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 33
- 230000001413 cellular effect Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000000921 morphogenic effect Effects 0.000 claims 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 6
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 6
- 229940112869 bone morphogenetic protein Drugs 0.000 description 6
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462007793P | 2014-06-04 | 2014-06-04 | |
| US62/007,793 | 2014-06-04 | ||
| US201562129720P | 2015-03-06 | 2015-03-06 | |
| US62/129,720 | 2015-03-06 | ||
| PCT/US2015/034275 WO2015187994A1 (en) | 2014-06-04 | 2015-06-04 | Method for non surgical repair of vertebral compression fractures |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017520537A JP2017520537A (ja) | 2017-07-27 |
| JP2017520537A5 true JP2017520537A5 (enExample) | 2018-07-12 |
| JP6683628B2 JP6683628B2 (ja) | 2020-04-22 |
Family
ID=54767394
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016571044A Active JP6683628B2 (ja) | 2014-06-04 | 2015-06-04 | 脊椎圧迫骨折の非外科的修復のための方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US11318166B2 (enExample) |
| EP (1) | EP3151847B1 (enExample) |
| JP (1) | JP6683628B2 (enExample) |
| WO (1) | WO2015187994A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3151847B1 (en) | 2014-06-04 | 2020-07-29 | Cedars-Sinai Medical Center | Human mesenchymal stem cells and pth for use in a method for non surgical repair of vertebral compression fractures |
| WO2018144719A1 (en) * | 2017-02-01 | 2018-08-09 | The Johns Hopkins University | Parathyroid hormone and regeneration of degenerative discs disease |
| KR102931395B1 (ko) * | 2017-11-09 | 2026-02-26 | 훗카이도 코리츠 다이가쿠 호진 삿포르 이카 다이가쿠 | 조직 재생용 의약 및 그 제조 방법 |
| WO2019113522A1 (en) * | 2017-12-08 | 2019-06-13 | Cedars-Sinai Medical Center | Neural crest cells to revitalize cranial allografts |
| CA3256601A1 (en) * | 2022-04-29 | 2023-11-02 | ThoraGenix Innovations, Inc. | SYSTEMS, METHODS AND DEVICES FOR DISTRIBUTING EXOSOMES TO FILL BONE FRACTURE VACUUMS |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| TW303299B (enExample) * | 1993-07-22 | 1997-04-21 | Lilly Co Eli | |
| US6077987A (en) * | 1997-09-04 | 2000-06-20 | North Shore-Long Island Jewish Research Institute | Genetic engineering of cells to enhance healing and tissue regeneration |
| CA2338712C (en) | 1998-07-28 | 2012-10-09 | Synergen Ag | Use of creatine compounds for treatment of bone or cartilage cells and tissues |
| US20040033950A1 (en) * | 2000-09-26 | 2004-02-19 | Hock Janet M. | Method of increasing bone toughness and stiffness and reducing fractures |
| US7635477B2 (en) * | 2002-07-25 | 2009-12-22 | The General Hospital Corporation | Parathyroid hormone receptor activation and stem and progenitor cell expansion |
| US8895540B2 (en) * | 2003-11-26 | 2014-11-25 | DePuy Synthes Products, LLC | Local intraosseous administration of bone forming agents and anti-resorptive agents, and devices therefor |
| JP2006346420A (ja) * | 2005-06-13 | 2006-12-28 | Univ Nagoya | 移植材料及び骨質改善剤 |
| US20070148144A1 (en) | 2005-10-27 | 2007-06-28 | Mason James M | Gene-enhanced tissue engineering |
| US20080286249A1 (en) | 2006-01-12 | 2008-11-20 | Varney Timothy R | Use of mesenchymal stem cells for treating genetic diseases and disorders |
| WO2009134532A2 (en) * | 2008-03-07 | 2009-11-05 | The Trustees Of Columbia University In The City Of New York | Homing in mesenchymal stem cells |
| US20090291061A1 (en) | 2008-05-21 | 2009-11-26 | Riordan Neil H | Stem cell therapy for blood vessel degeneration |
| EP3151847B1 (en) | 2014-06-04 | 2020-07-29 | Cedars-Sinai Medical Center | Human mesenchymal stem cells and pth for use in a method for non surgical repair of vertebral compression fractures |
-
2015
- 2015-06-04 EP EP15803714.3A patent/EP3151847B1/en active Active
- 2015-06-04 US US15/315,704 patent/US11318166B2/en active Active
- 2015-06-04 JP JP2016571044A patent/JP6683628B2/ja active Active
- 2015-06-04 WO PCT/US2015/034275 patent/WO2015187994A1/en not_active Ceased
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