JP2017500099A - Intraocular lens - Google Patents

Abstract

The intraocular lens includes a soft optical component and at least one rigid plate-type haptic component connected to the optical component. At least one rigid plate-type haptic component comprises a rigid structure. The at least one rigid plate-type haptic component can withstand bending due to pressure applied to the tip of the at least one haptic component by contraction of the ciliary muscle. The intraocular lens is a non-adjustable IOL that has a fixed longitudinal length and is configured to withstand deformation due to the action of the ciliary muscle. Various embodiments also include an accommodating intraocular lens.

Description

  The present disclosure relates to intraocular lenses for implantation in the eye.

  A currently commonly used surgical procedure for treating cataracts involves implanting an intraocular lens (IOL) into the eye. In such a procedure, the normal human lens that is turbid due to cataract is generally replaced by an IOL.

  Many breakthrough changes in cataract surgery over the last 40 years have resulted in reliable surgical procedures that regularly produce good patient outcomes. Modern surgical techniques have also made surgery very safe when performed by competent surgeons.

  Currently, the treatment can also be considered a surgical means to treat myopia, hyperopia or astigmatism because an IOL with the appropriate power that provides optical correction can be inserted into the eye.

  One of the remaining problems to be solved is to make the post-vision naked eye distance vision more accurate than the current state (eg, without using glasses or contact lenses). In that case, this procedure makes the lens surgery comparable to corneal surgery as far as the naked eye vision is concerned, and general surgical cataract surgery or removal of the clear lens, refractive procedure. ).

  Recently, lenses have been developed to treat presbyopia. There are two types: multifocal and adjustable. Because light entering the eye has more than one focus, patients implanted with a multifocal lens have less than half the light focused at a time, so halo, glare, fog vision and contrast There is a problem with the decrease in sensitivity. Many of these lenses had to be explanted due to these problems. An adjustable lens designed to move forward as the ciliary muscle contracts by looking closer has also been invented. Near vision with these lenses is not as good as near vision with multifocal lenses, but does not have the problems associated with multifocal lenses.

  Two of the remaining problems to be solved are to make the post-operative naked eye far vision more accurate than the current state, and using the single focus lens, excellent far vision in the naked eye, near vision , And their intermediate vision. Therefore, as far as the naked eye vision is concerned, this makes the lens surgery comparable to the corneal surgery, and the general surgical cataract surgery or the removal of the transparent lens is safer than the corneal refractive surgery and corneal presbyopia surgery. Use refractive surgery with few complications.

  The various embodiments described herein are more accurate at more consistent, repeatable and predictable locations along the optical or visual axis of the eye compared to other lens designs. It comprises an intraocular lens structure in which the optical components of the intraocular lens are arranged, thereby making the post-operative naked eye vision more predictable (eg, without using eyeglasses or contact lenses).

  The present disclosure describes, for example, an intraocular lens that includes rigid haptics connected to a foldable optical component. By properly connecting a foldable optical component to a rigid tactile component, the tactile component deforms when subjected to the action of the ciliary muscle after implantation into an empty capsule bag during cataract surgery Can be suppressed. In various embodiments described herein, two rigid haptic components of substantially equal length were when placed in the capsular bag during surgery along the optical or visual axis of the eye. It is designed to keep the lens optical components roughly in the same position. The lens may be designed to be slightly longer or shorter than the lens capsule, and may be designed to be flush, curved, or angled. The tactile component in some embodiments has a fixed angle between 5 and 40 degrees with respect to the optical component at the time of manufacture, and the lens optical component is moved forward or backward when inserted into the lens capsule. Bent into an arch shape.

  Accordingly, various embodiments relate to non-accommodating intraocular lenses having at least one rigid haptic component connected to a soft optical component. The hard structure is hard in the vertical direction and soft in the horizontal direction. The longitudinal length of the intraocular lens is fixed before insertion into the eye. At least one haptic component can be directly connected to the optical component when the lens is manufactured as a single unit, or can be indirectly connected to the optical component by a short extension of the optical component.

  In any of the non-adjustable lens embodiments described herein, the ciliary muscle force may be insufficient to move the optical component forward, for example. For example, various embodiments may include any soft connection (eg, hinge, torsion bar, etc.) that allows the optical component to move relative to the tactile component by movement of the ciliary muscle. Do not have between.

  A longitudinally rigid haptic component comprises the same material as the soft optical component and can be manufactured in one piece, and the haptic component is made rigid by increasing its thickness and / or its width. The rigid haptic component can be rigidized by a rigid structure having a chassis (or frame) partially or fully embedded in a soft material of an optical component such as silicone or acrylic. The hard material of the chassis is designed to harden the haptic component and to fix the lens within the lens capsule of the eye. The internal chassis extends tangentially from the lateral side of the front end of the chassis, and is fixed using a soft loop (open loop or closed loop) adjacent to the internal chassis and within the diameter of the optical component Can be done by at least one of creating an open space in a closed loop, or by a closed loop that extends beyond the diameter of the optical component. The loop may be configured to be rigid or compressible. For example, these loops may be configured to remain fixed length regardless of ciliary muscle contraction or fibrosis.

  In any of the intraocular lens embodiments described herein, including those described above, the rigid structure may include at least one strut extending in the longitudinal direction. In certain aspects, the rigid structure at least partially includes at least one strut extending longitudinally to form at least one open region (eg, one, two, or three open regions). May include a closed structure. In certain aspects, the loop structure may include a first width and a second width. The first width can be made closer to the tip of the loop structure, and the first width can be made wider than the second width. In certain aspects, the loop structure may have a width that is narrower than a width of at least one strut extending in the longitudinal direction. For example, the width of the loop structure can be less than about 25% and greater than about 5% of the width of at least one strut extending in the longitudinal direction (eg, less than 20%, less than 15%, Or less than 10%).

  In any of the intraocular lens embodiments described herein, including those described above, the rigid haptic component has a T-shaped soft finger at the tip of the haptic component that is otherwise rigid. May be.

  In any of the intraocular lens embodiments described herein, including those described above, the rigid structure may be a plate-type haptic component. The plate-type haptic component may include a thin bar disposed at either the distal end or the proximal end of the haptic component. Furthermore, the plate-type haptic component may include an open area in the proximal direction of the thin bar.

  In any of the intraocular lens embodiments herein, including those described above, the optical component can be in a single plane, or tilted back or forward during manufacture prior to insertion into the eye. Can be placed. The structure may also have a fixed length that can withstand deformation due to the action of the ciliary muscle.

  Accordingly, various embodiments disclosed herein may have an intraocular lens comprising a soft optical component and at least one haptic component connected to the optical component. At least one haptic component comprises a rigid structure. The intraocular lens includes a non-adjustable IOL whose vertical length is fixed.

  Various embodiments have an intraocular lens comprising a soft optical component and at least one haptic component connected to the optical component, wherein the hard haptic component is harder than the soft optical component. In such embodiments, the intraocular lens may comprise a non-adjustable IOL.

  Various embodiments comprise an intraocular lens, in which a soft optical component may be connected to a tactile component of the same material, and the tactile component expands or thickens the structure of the tactile component Alternatively, it may be configured to be rigid by a combination of spreading and thickening. In some embodiments, the intraocular lens generally comprises the same material (eg, acrylic). In some embodiments, the intraocular lens comprises a monolith structure.

  As mentioned above, in any of the non-adjustable lens embodiments described herein, the ciliary muscle force may be insufficient to move the optical component forward, for example. For example, various embodiments may include any soft connection (eg, hinge, torsion bar, etc.) that can move the optical component relative to the tactile component in response to ciliary muscle movement. Do not have between.

  Certain aspects of the present disclosure are directed to non-adjustable single focus intraocular lenses configured to provide naked eye vision at all distances. The lens has optical components including haptic components and semi-rigid acrylic, which can be deformed for implantation into the eye through a small incision, but its optical properties and physical properties after implantation into the eye It can regain its properties and withstand deformation when force is applied by ciliary muscle or fibrosis.

  Certain aspects of the present disclosure relate to an intraocular lens having a single focus acrylic optical component and at least one semi-rigid acrylic tactile component connected to the optical component. The intraocular lens may have a fixed longitudinal length (eg, the same fixed length before and after surgery). Intraocular lenses are resistant to deformation after implantation into the eye using, for example, the semi-rigid haptic components described herein, regardless of ciliary muscle contraction and relaxation, and fibrosis within the lens capsule. Can endure. The intraocular lens is sufficiently soft to be compressed from its original configuration to a compressed configuration for insertion into the eye through a small incision, and after implantation into the eye, it has a normal shape (eg, an uncompressed shape). ).

In some embodiments, the above-described intraocular lens may be configured to provide naked eye vision at near, intermediate, and far distances.
In any of the single focus intraocular lens embodiments described herein, including those described above, the optical component may be disposed at a fixed angle with respect to the tip of the at least one haptic component and tilted rearward. . The tilt can remain unchanged after implantation into the eye. Further, in some embodiments, the vault angle can remain unchanged after implantation into the eye. In certain aspects, the at least one haptic component may be disposed tilted forward. In certain aspects, the at least one haptic component includes two haptic components, both of which may be disposed tilted forward. In certain aspects, the vault angle can be from about 1 degree to about 50 degrees.

  In any of the single focus intraocular lens embodiments described herein, including those described above, the semi-rigid haptic component may include at least one strut extending in the longitudinal direction. In certain aspects, the rigid structure at least partially includes at least one strut extending longitudinally to form at least one open region (eg, one, two, or three open regions). May include a closed structure. In certain aspects, the loop structure may include a first width and a second width. The first width can be made closer to the tip of the loop structure, and the first width can be made wider than the second width. In some aspects, the width of the loop structure may be shorter than the width of at least one longitudinally extending strut. For example, the width of the loop structure can be less than about 25% and greater than about 5% of the width of at least one strut extending in the longitudinal direction (eg, less than 20%, less than 15%, Or less than 10%).

  In any of the single-focus intraocular lens embodiments described herein, including those described above, the semi-rigid haptic component is a T-shaped haptic at the tip of the haptic component that is otherwise semi-rigid. It may have compressible soft lateral fingers to constitute the part.

  In any of the single focus intraocular lens embodiments described herein, including those described above, the semi-rigid structure may be a plate-type haptic component. The plate-type haptic component may include a soft thin tip lateral finger that forms a T-shaped haptic component.

  In any of the single focus intraocular lens embodiments described herein, including those described above, the semi-rigid haptic component may be harder than the soft optical component. Since the optical component can be soft at its thin perimeter and semi-rigid at its center, it can be inserted into the eye through a small incision having a length of about 3.0 mm or less, preferably about 2.5 mm or less. The optical component can be folded into a configuration that is elongated in the vertical direction.

  In various embodiments, the intraocular lens may be a non-accommodating IOL. In certain embodiments, the unaccommodated IOL is designed to provide distance vision, intermediate vision, and near vision. In certain embodiments, this unaccommodated IOL provides such vision without the glare, halo and fog vision, and contrast reduction problems experienced with multifocal intraocular lenses.

  In any of the single-focus intraocular lens embodiments described herein, including those described above, the posteriorly vaulted optical component is connected to the same semi-rigid material haptic component; The tactile component is configured to be harder by expanding or thickening its structure, or by a combination of expanding and thickening.

  Some aspects of the present disclosure relate to a non-accommodating intraocular lens having a single focus optical component and at least one semi-rigid haptic component connected to the optical component. The optical component may be bent arched at a fixed angle (eg, posteriorly) with respect to the at least one haptic component prior to surgery. The optical component may remain bent in an arch after implantation, and in some embodiments, the vault angle may remain unchanged after implantation. The semi-rigid haptic component is soft enough to be compressed for insertion into the eye through a small incision, and can take the usual uncompressed shape after implantation into the eye. In some embodiments, the lens may be configured to provide naked eye vision at near, intermediate, and far distances.

  In any of the non-adjustable intraocular lenses described herein, including those described above, the at least one semi-rigid haptic component can be tilted forward. In a particular aspect, the at least one semi-rigid haptic component includes two haptic components, both of which are arranged tilted forward.

In any of the non-adjustable intraocular lenses described herein, including those described above, the vault angle can be about 1 degree to about 50 degrees, such as about 5 degrees to about 40 degrees.
In any of the non-accommodating intraocular lenses described herein, including those described above, the optical component and the at least one haptic component can include the same material (eg, acrylic or silicone). Certain aspects of the present disclosure relate to implanting non-accommodating intraocular lenses having optical components connected to at least one haptic component. The intraocular lens can have any of the features described herein. Prior to surgery, the intraocular lens may be bent arched backwards at a fixed angle relative to the at least one haptic component. The intraocular lens can be compressed for insertion into the eye through a small incision. After implantation, the intraocular lens is normally uncompressed with sufficient resistance to withstand intraocular pressure changes, such as intraocular pressure changes caused by the ciliary muscles to be fitted or fibrosis. Can take shape. After implantation, the intraocular lens can remain bent in an arch, and in some embodiments may remain bent in an arch at the same fixed angle.

  Certain aspects of the present disclosure relate to a non-accommodating intraocular lens having a single focus acrylic optical component and at least one haptic component connected to the optical component. The optical component can be bent arched at a fixed angle relative to the at least one haptic component prior to surgery. The optic can remain arcuate after implantation, and in some embodiments, the vault angle can remain unchanged after implantation. In some embodiments, the intraocular lens may be configured to provide naked eye vision at near, intermediate, and far distances.

  In any of the non-adjustable intraocular lenses described herein, including those described above, the at least one haptic component can be tilted forward. In certain aspects, the at least one haptic component may include two haptic components that are tilted forward.

In any of the non-accommodating intraocular lenses described herein, including those described above, the vault angle can be about 1 degree to 50 degrees, such as about 5 degrees to about 40 degrees.
In any of the non-accommodating intraocular lenses described herein, including those described above, the optical component and the at least one haptic component can include the same material.

  Certain aspects of the present disclosure relate to an adjustable intraocular lens comprising a lens optic and a pair of opposing plate-type haptic components coupled to the lens optic. Each plate-type haptic component may include a rigid frame at least partially embedded in a soft component. The rigid frame may include a number of openings along the tip portion of the frame. At least a portion of at least some of the openings may extend beyond the leading edge of the soft component. The transverse width of the rigid frame measured between opposing lateral edges of the rigid frame can be wider than the transverse width of the flexible component measured between opposing transverse edges of the soft component. The rigid frame may extend beyond the proximal edge of the soft component.

  In any of the adjustable intraocular lenses described herein, including those described above, each plate-type haptic component can include a connection portion connected to an optical component. The connection portion may include a short appendage connected to the optical component and at least one connection bar extending laterally from the short appendage. The at least one connection bar may include a first connection bar and a second connection bar. The first and second connection bars can extend laterally from opposite sides of the short appendage.

In any of the adjustable intraocular lenses described herein, including those described above, each plate-type haptic component can include an elongated slot.
In any of the adjustable intraocular lenses described herein, including those described above, each plate-type haptic component may include at least one front protrusion that extends forward from the plate-type haptic component.

  In any of the adjustable intraocular lenses described herein, including those described above, each plate-type haptic component can include an opposing lateral paddle. The transverse width measured between the outer lateral edges of opposing paddles of the same haptic component can be greater than the transverse width of the optical component.

  Certain aspects of the present disclosure relate to an adjustable intraocular lens comprising a lens optic and a pair of opposing plate-type haptic components coupled to the lens optic. Each plate-type haptic component may include a rigid frame having a number of openings.

  In any of the adjustable intraocular lenses described herein, including those described above, the rigid frame is at least partially embedded in the soft component. In some embodiments, the rigid frame may include a number of openings along the tip portion of the frame. In various embodiments, some of at least a portion of at least some of the openings can extend beyond the leading edge of the soft component. In some embodiments, the rigid frame extends beyond the proximal edge of the soft component.

  In any of the adjustable intraocular lenses described herein, including those described above, the transverse width of the rigid frame measured between opposing transverse edges of the rigid frame is the opposite transverse direction of the soft component. Wider than the transverse width of the soft component measured between edges.

  In any of the adjustable intraocular lenses described herein, including those described above, each plate-type haptic component may include a connection portion connected to an optical component. The connection portion may include a short appendage connected to the optical component and at least one connection bar extending laterally from the short appendage. The at least one connection bar may include a first connection bar and a second connection bar. The first connection bar and the second connection bar may extend laterally from opposing sides of the short appendage.

In any of the adjustable intraocular lenses described herein, including those described above, each plate-type haptic component can include an elongated slot.
In any of the adjustable intraocular lenses described herein, including those described above, each plate-type haptic component may include at least one front protrusion that extends forward from the plate-type haptic component.

  Any of the intraocular lenses described herein, including those described above, can include a first plate-type haptic component and a second plate-type haptic component, wherein the first plate-type haptic component includes: The optical component and the first plate-type haptic component are coupled to the optical component at a first setting angle that is not zero, and the second haptic component is between the optical component and the second plate-type haptic component. Coupled to the optical component at a second non-zero set angle, the second non-zero angle is different from the first non-zero angle. In various embodiments, the lens is configured such that when the lens is placed in the lens capsule of the eye, the upper hemisphere of the optical component is positioned posteriorly relative to the lower hemisphere at the 12 o'clock position. Is done. In some embodiments, the upper hemisphere is configured to focus light for distance vision. In certain embodiments, the first non-zero angle is greater than or equal to 10 degrees and less than or equal to 50 degrees. Similarly, in certain embodiments, the non-zero second angle is at least about 20 degrees and no more than about 50 degrees.

  Also, in any of the intraocular lenses described herein, including those described above, the optical component may be a progressive power lens that includes an increasing power gradient, for example when implanted into the eye. , Providing far vision in the upper hemisphere of the optical component and near vision in the lower hemisphere of the optical component.

  A wide variety of variations are possible. For example, any feature, structure, or step disclosed herein can be replaced with, combined with, or omitted from any other feature, structure, or step disclosed herein. Can. Furthermore, in order to summarize the present disclosure, certain aspects, advantages, and features of the present invention have been described herein. It should be understood that any or all such advantages may not necessarily be achieved in accordance with any particular embodiment of the invention disclosed herein. Aspects of the present disclosure are neither essential nor essential.

  Various embodiments are shown in the accompanying drawings for purposes of illustration and are not to be construed as limiting the scope of the embodiments in any way. Moreover, various features of different disclosed embodiments may be combined to form additional embodiments that are part of this disclosure.

Fig. 4 shows a non-adjustable lens with a loop (e.g. an open loop) comprising an optical component that can be bent back arched and a monolithic haptic component comprising, for example, acrylic as one material. The haptic component is wider than the traditional loop-type haptic component and can be manufactured flat. Fig. 2 shows a non-accommodating intralens (NAIL) non-accommodating intraocular lens of a plate-type haptic component with a small fixed loop all made in one piece. The optical component can be bent back arched. FIG. 6 illustrates an embodiment of a haptic component comprising a single rigid longitudinal structure having a T-shaped soft tip transverse extension. Fig. 2 shows a non-accommodating intraocular lens (NAIL) having a chassis embedded in the same soft material as the optical component. FIG. 5 is a view similar to FIG. 4 but without a fixed loop. Two exposed rigid longitudinal plates or struts connected by a thin transverse bar to create an enclosed open space, and a fixation loop (e.g., open loop) that facilitates fixation of the lens in the lens capsule. Another NAIL is shown. The lens may be designed without soft fingers, since the fixation can occur over the thin transverse bar 9. The width of the thin arm 9 can be shorter than the width of the longitudinal plate or column 7. FIG. 6 shows yet another NAIL with longitudinal plates or struts connected by thin transverse bars, but without a fixed loop. Fig. 6 illustrates another embodiment of a haptic component having a two-loop structure of rigid haptic components. FIG. 6 shows a rigid tactile component intraocular lens having a three-loop structure, with three loops (eg, closed loop) partially covered with the same soft material as the optical component. FIG. 6 shows a rigid tactile component intraocular lens having a three-loop structure, with three loops (eg, closed loop) partially covered with the same soft material as the optical component. FIG. 6 shows a rigid tactile component intraocular lens having a three-loop structure, with three loops (eg, closed loop) partially covered with the same soft material as the optical component. FIG. 6 shows a rigid tactile component intraocular lens having a three-loop structure, with three loops (eg, closed loop) partially covered with the same soft material as the optical component. FIG. 3 shows a side view of the optical components of the intraocular lens bent back arched. FIG. 6 shows a side view of an optical component of an intraocular lens bent forward in an arch shape. FIG. 3 shows a side view of an intraocular lens having haptic components arranged in a common plane. FIG. 2 is a schematic diagram illustrating a lens with optical and tactile components configured in an extended “z” shape. FIG. 5 is a schematic diagram showing how far, near and intermediate distances can be focused on the retina by tilting the optical components. 1 shows a schematic view of an intraocular lens implanted in a lens capsule. FIG. FIG. 3 shows a schematic diagram of an embodiment of an accommodating intraocular lens having a closed loop tactile component. FIG. 3 shows a schematic diagram of an embodiment of an accommodating intraocular lens having a closed loop tactile component. FIG. 3 shows a schematic diagram of an embodiment of an accommodating intraocular lens having a closed loop tactile component. FIG. 3 shows a schematic diagram of an embodiment of an accommodating intraocular lens having a closed loop tactile component. 1 illustrates an embodiment of a haptic component having a single thick rigid longitudinal haptic component structure, wherein the haptic component structure is tilted forward or bent into an arch shape and is a T-shaped soft It has a tip lateral extension. FIG. 6 shows another lens design with two thick rigid longitudinal plates or struts 7 connected by a thin transverse bar 9, thereby creating an enclosed open space 12 (eg, closed loop) and a soft thin tip It facilitates the fixation of the lens in the lens capsule together with the lateral fingers 6. The lens may be designed without soft fingers, since the fixation can occur over the thin transverse bar 9. The width of the thin arm 9 can be shorter than the width of the longitudinal plate or column 7. A lens design with a thick longitudinal central plate 20 having a width of less than about 3.0 mm, the plate 20 having two closed loops 21 that provide two open spaces 22 for securing the lens to the capsular bag. . A half of a lens with a haptic component 1 having a transverse member (or paddle) 30 is shown. The haptic component 1 can be wider than the optical component 2 and the tip 31 of the transverse member 30 can be designed to be posterior to the optical component after implantation. The haptic component 1 constitutes a closed loop 12. A half of a lens comprising a haptic component 1 with a transverse member 30 is shown. The haptic component 1 can be made wider than the optical component by a finger-like soft lateral extension 6.

  Many intraocular lenses have optical components that are connected to two or more soft tactile components that serve to center and fix the lens in an empty capsular bag of the human lens. These haptic components can be formed by two soft loops.

  The circular ciliary muscle inside the eye, which is part of the autonomic nervous system and is active throughout life, is involved in activities that change the focus of the eye. When a patient with a standard loop intraocular lens tries to look early after surgery after cataract surgery, the still-active ciliary muscle (eg, in the longitudinal direction of the lens) has end-to-end pressure. In addition, this pressure acts on the soft loop to move it toward the front, back, center and periphery within the lens capsule. This movement can shift the position of the lens within the lens capsule. In addition, fibrosis occurs at this time, and the loop is not necessarily fixed to the capsular sac of the lens capsule placed at the time of surgery. Alternatively, the loop may be fitted somewhere between the capsular capsule and the optic, for example. By changing the position of the tactile component loop within the capsular bag, the position of the lens optic can also be changed along the axis of the eye, resulting in decentration and tilt of the optic. In some soft loop designs, the thin flimsy soft loops at manufacture are significantly longer than the capsular capsule diameter of 10 mm (eg, up to 12 mm length) and act through the capsular bag wall to cause ciliary It may act on body muscles. The haptic component can be thin and light and can be easily deformed by pressure applied to the haptic component early after surgery. Therefore, the lens position is not at the position that would be calculated and predicted. Accordingly, far vision and post-operative refractive power with the naked eye (eg, without the use of glasses or contact lenses) would not be expected before surgery. In some cases, the lens loop is compressed centrally so that it is located in front of or behind the lens optics.

The various embodiments described herein are more accurate in terms of more consistently repeatable and predictable points along the optical or visual axis of the eye compared to other lens designs. An intraocular lens structure is provided that places the optical components of the inner lens, thereby making the post-operative naked eye vision more predictable (eg, without using eyeglasses or contact lenses).
Non-Accommodating Lens For example, see the intraocular implant shown in FIGS. The intraocular implant comprises an optical component 2 and an opposing rigid haptic component 1 (eg, a plate-type haptic component) and optionally has a soft loop lateral extension 6 (eg, open loop) (FIGS. 3 and (See FIG. 4). However, in FIGS. 4-8, only one of two tactile components is shown. The tactile component 1 may be connected directly to the optical component 2 (see FIGS. 1 and 2) or connected to the short and thick rigid extension 3 of the optical component 2 (see FIGS. 3 to 8). Can be configured as a single piece (eg, a monolith) at the time of manufacture, or formed separately and connected together. The short extension 3 can be made from the same material as the optical component 2. Furthermore, the short rigid extension 3 can be formed integrally with the optical component 2 or separately from the optical component 2. To facilitate the connection, holes 8 are made through the rigid components of the haptic component, and during the manufacturing process, the flexible component 103 or the rigid extension 3 can be fused and united through the holes. (See FIGS. 3 to 8). A short and thick rigid extension 3 may be desired to facilitate the connection between the optical component 2 and the haptic component 1 without penetrating on the outer periphery of the optical component 2.

  The optical component 2 may comprise a substantially transparent biocompatible soft optical material, such as acrylic, hydrogel, or silicone, and the optical component 2 is biconvex, plano-convex, concave / flat, annulus, aspherical Or a spherical Fresnel multifocal or any combination thereof. The optical component 2 may be a progressive power lens with an increasing refractive power gradient, for example providing far vision in the upper hemisphere of the optical component when implanted into the eye and near vision in the lower hemisphere of the optical component. May bring. The optical component 2 may be used in combination with the second optical component in the eye.

  The haptic component 1 can be designed to be rigid and resistant to deformation due to the action of the ciliary muscle. In particular, the haptic component may be resistant to pressure applied in the longitudinal direction by the ciliary muscle without bending. Traditionally, the hard haptic component 1 is resistant to compression, unlike the soft haptic component 1 used with non-adjustable and adjustable lenses, so the hard haptic component 1 is centered. ) To make the optical components more consistently positioned along the eye axis.

  As shown in FIG. 1, in some embodiments, the haptic component 1 may include an open loop. Some haptic components 1 may include one or more closed loops (see also FIGS. 6-9 described more fully below).

  FIG. 1 shows a lens made of, for example, acrylic as a single piece, with an optical component 2 adjacent to a curved open loop, such as a rigid tactile component 1. As with all these lens designs, the lens may be on a single plane, or the optic 2 may bend arched backwards or forwards during surgery.

FIG. 2 shows a lens made of one material (eg acrylic) with a rigid plate-like tactile component structure 4 ′ and a small tip locking finger 5.
FIG. 3 schematically shows an embodiment of the haptic component 1 having a single rigid longitudinal structure 11, the structure 11 and the soft tip lateral extension 6 forming a T-shape. The rigid longitudinal structure 11 is attached to the short and thick extension 3 of the optical component 2 or is connected to the optical component 2.

  4 and 5 show a haptic component 1 comprising a chassis 104 that includes two rigid struts / plates 101 and a proximal transversal connection bar 102 (at its proximal end) between the two struts / plates 101. . The chassis 104 embedded in the soft optical material 103 has external tip fixing fingers 6 in FIG.

  FIG. 6 shows a haptic component 1 comprising two rigid struts / plates 7, which comprise a finger-like extension 6 with a distal end 10 such as a knob, during the manufacturing process. In the proximal direction, it is embedded in the thick hard extension 3 of the optical component 2 or the soft material is fused and integrated through the hole 8 to be fixedly connected to the optical component. The two plates 7 are connected at the tip by a thin transverse crossbar 9. The two rigid struts / plates 7 and the transverse crossbar 9 form an open space in the longitudinal direction between the transverse crossbar 9 and the optical component 2.

  FIG. 7 fuses the anterior and posterior capsules over the top of the thin tip connection bar 9 to form fibrous tissue through the open space 12 surrounded by the struts / plate 7, the bar 9 and the thick rigid extension 3. This is similar to FIG. 6 except that fixation in the capsular bag is achieved without the soft fingers 6. The width of each strut can be 1.0-3.0 mm so that the lens can be folded vertically to be compressed for insertion through an incision of 3.0 mm or less.

  FIG. 8 shows a haptic component 1 that includes a single plate 20 with two rigid closed loops 21 attached to each side of the plate 20 so that the lens capsule forms fibrous tissue and the lens haptic component 1. Provides two enclosed spaces 22 or openings that can be secured within the capsular bag.

  10, 11 and 12A show possible side views of the lens, which can be bent back arched (FIG. 10) and forward (FIG. 11) arched. And can be on a plane (FIG. 12A). FIG. 10 and FIG. 11 show the optical component bent in an arch shape backward and forward, respectively, with respect to the tip of the tactile component at the time of implantation. The lens shown in FIG. 10 may include, for example, a coplanar accommodation lens as described herein that is bent into an arch when implanted. As described herein, the lens shown in FIG. 10 may also be manufactured with the haptic component tilted (eg, forward) relative to the optical component to increase the depth of focus. Good. As the optical component is bent back arched with respect to the tip of the haptic component, the optical component may be able to take a suitable position to increase the depth of focus.

  In other embodiments, such as shown in FIG. 12B, each of the tactile components can be tilted or fixed in different directions so that the lens forms a z-shape with the lens extended outward, eg, an optical component On the other hand, for example, the first haptic component can be disposed or fixed to be tilted forward, and the second haptic component can be disposed or fixed to be tilted backward. Each of the haptic components can be placed or fixed at a non-zero angle relative to the optical component. The first haptic component may be tilted or fixed at a non-zero first angle, and the second haptic component may be at a non-zero second angle that is different from the non-zero first angle. Can be tilted or fixed. With the tactile component tilted in different directions, the optical component can be tilted as shown in FIG. 12C so that the upper hemisphere of the optical component tilts backward when the lens is placed in the lens capsule. The lower hemisphere of the optical component is tilted forward. In this configuration, when implanted in the eye, the upper hemisphere can be positioned to improve distance vision while the lower hemisphere can be positioned to improve near vision. Such a tilted arrangement is described in US patent application Ser. No. 13 / 953,605 (Attorney Docket No. CORD.005C1) published as US 2014 / 0172093A1. The entirety of which is incorporated herein by reference.

FIG. 13 shows a schematic view of the non-adjustable intraocular lens 100 in the lens capsule. An anterior capsule edge 50, a posterior capsule 51, and an anterior capsule edge 52 that is a capsular capsular capsule are shown.
The lens described above is designed to have a soft optical component 2 connected to a rigid haptic component 1 (eg, a plate-type haptic component) that is rigid in the longitudinal direction but soft in the lateral direction. Can be compressed into an insertion device to be inserted into the eye through an incision of 3.0 mm or less. The haptic component 1 is sufficiently rigid to prevent bending in the longitudinal direction when subjected to pressure applied by ciliary muscle action and fibrosis. The narrow transverse bar 9 of the chassis 104, when present, is soft so that the lens can be folded and compressed around the longitudinal axis.

  In various embodiments, the total length D of the lens 100 may be between about 9.5 mm and about 14.0 mm when measured diagonally from the tips of the fixed lateral loop 6 on either side of the lens 100. For example, refer to FIG. 3 and FIG. The diagonal distance D extends through the center of the optical component 2. The longitudinal length L of lens 100 (also shown in FIGS. 3 and 13) can be at least the diameter of the average lens capsule. For example, the longitudinal length of the lens 100 can be from about 9.5 mm to about 12.0 mm, with a preferred length being about 10.5 mm in various embodiments, this length being specified In this embodiment, it is slightly longer than the average capsular diameter. When the length of the lens 100 is about 10.5 mm or less, the lens 100 does not deform the lens capsule and does not act on the ciliary muscle.

  The haptic component 3 extending from the soft optical component 2 is rigidly configured in some embodiments by its short length of less than 1 mm and a thickness of more than 1 mm, and at least a part of the component 3 May include acrylic, silicone or other inert soft materials, and rigid components, polyimide, acrylic or other rigid materials. In some embodiments, the haptic component 1 may be configured to be rigid in the vertical direction, provided that it is based on a combination of hard materials 104 embedded within the soft material 103. At least one of the rigid struts and plate 7 is polyimide, prolene, or any derivative of nylon, PMMA titanium, other rigid materials, or inert materials, so as to make the haptic component 1 rigid in the longitudinal direction, Alternatively, a combination of a hard material and a soft material may be included.

  In some embodiments, the intraocular lens may include at least one (eg, two, three, or more) semi-rigid haptic component and an optical component. In some embodiments, the at least one semi-rigid haptic component and the optical component can include the same material (eg, acrylic). In some embodiments, the intraocular lens can be a monolith or a single body. The semi-rigid haptic component and the optical component may be foldable to insert the optical component into the eye through a small incision. However, after insertion and regaining its shape, it is resistant enough to withstand changes in pressure in the eye caused by the contraction and relaxation of the ciliary muscles and the forces generated during postoperative fibrosis. Have. The lengths of the two semi-rigid haptic parts can be equal. The resistance to ciliary muscle action and fibrosis deformation is substantially the same position along the optical or visual axis of the eye as when the lens optic was placed in an empty lens capsule at the time of surgery. To leave. For example, to achieve optimal depth of focus, the lens may be designed to be slightly longer or shorter than the capsular bag, and the haptic component (eg, the tip of the haptic component) is approximately 1 at manufacture. To the optical component at a fixed angle between about 50 degrees, for example about 5 degrees to about 40 degrees (eg, about 5 degrees to about 20 degrees, about 10 degrees to about 25 degrees, or about 15 to about 40 degrees). It may be angled with respect to it. Thereby, when inserting in a crystalline lens capsule, a lens optical component is positioned in a back position with respect to the front-end | tip part of a tactile component.

  Various embodiments relate to a non-adjustable intraocular lens having an optical component that is manufactured in one piece with the optical component tilted backward relative to the tip of the haptic component or bent in an arch shape. The tilt angle or vault angle may be the same at both optical component / tactile component joints. The semi-rigid lens structure can withstand deformation due to ciliary muscle and fibrosis but can be folded longitudinally to be inserted into the lens capsule of the eye through an incision less than 4.0 mm. it can.

  The total length of the lens in the longitudinal direction can be about 9.5 to about 12 mm, and its length can be slightly longer than the lens capsule, and preferably about 10.5 mm. When the length of the lens 100 is about 10.5 mm or less, the lens 100 does not deform the lens capsule and does not act on the ciliary muscle.

  Both semi-rigid haptic components can be the same length. The diameter of the optical component can be 4.0 to 8 mm and the thickness of the thin center can be about 0.2 to about 2.0 mm. Since the semi-rigid material resists deformation due to ciliary muscle and fibrosis, the haptic component cannot deform significantly, so the lens optic is in the same position as it was at the time of surgery after surgery. Similarly, the orientation of the intraocular lens after surgery can be the same as before surgery along the axis of the eye and on the axis of rotation where the toric lens is to be implanted. This makes the predictability of the effective lens position (ELP) after surgery along the visual axis of the eye more accurate, and therefore makes the naked eye vision more predictable. The longitudinal length of the intraocular lens can be fixed before being inserted into the eye, for example, the longitudinal length of the intraocular lens can be the same before and after surgery. However, the lens may have a thin, soft tip lateral finger to produce a lateral diameter that is longer than the longitudinal diameter. These soft fingers can be designed to secure the lens within the capsular bag and prevent lens rotation when the toric optic is part of the lens design.

  As described above, the longitudinal rigid haptic component can have the same material as the soft optical component and can be manufactured as one piece. A semi-rigid haptic component can be made more rigid by increasing its thickness and / or its width. Fixing uses a soft loop (open loop or closed loop) continuous with the lens body extending tangentially from the lateral side of the tip of the plate-type haptic component design, or open space within the diameter of the haptic component As well as at least one of a closed loop extending beyond the diameter of the optical component. The loop of semi-rigid material may be soft and thin so as to be compressible, but may be sufficiently rigid to maintain the length of the lens when subjected to forces from the ciliary muscle.

  However, the various embodiments disclosed herein can address the problems described above. For example, refer to the intraocular implant shown in FIG. The intraocular implant includes an optical component 2 and a semi-rigid haptic component 1 that is disposed at an opposing forward tilt, the semi-rigid haptic component 1 bending with a soft loop lateral extension 6 (eg, open loop). The joint 4 is directly connected to the optical component. 16-18, only one of the two halves of the lens is shown. The lens can have two-fold symmetry, with the other half being the same as shown. The short optical component extension 3 may have a hard bend joint 4 between the optical component 2 and the haptic component 1. The optical component 2 and the haptic component 1 can be made from the same material (eg, acrylic). The short optical component extension 3 may be desired to facilitate the connection between the optical component 2 and the haptic component 1 without the haptic component 1 entering the outer periphery of the optical component 2. The intraocular lens of FIGS. 16-18 may include any of the features described in connection with FIGS. Although the haptic component 1 does not include a through hole through which the optical component extension 3 can extend, these embodiments can also include a through hole, unlike those figures. Similarly, any of the features or combinations of features of the embodiments shown in any of FIGS. 15-18 may be included in any of the other lenses shown in FIGS. For example, the bending joint 4 shown in FIGS. 15 to 18 (as well as FIG. 9) can be included in FIGS.

  The lens may comprise a transparent biocompatible soft optical material such as acrylic, and the optical component may be biconvex, plano-convex, concave / flat, toric, aspherical, spherical, Fresnel, multifocal, or Any combination thereof may be used. The optical component 2 may be a progressive power lens that includes an increasing refractive power gradient, for example, when implanted in the eye, provides near vision to the lower hemisphere of the optical component and far vision to the upper hemisphere of the optical component. Bring.

  The tactile component 1 is semi-rigid at least in the longitudinal direction, and is designed to withstand the action of ciliary muscle or deformation due to fibrosis. Unlike the soft tactile component traditionally used with non-accommodating lenses and accommodating lenses, the longitudinal semi-rigid tactile component 1 is resistant to deformation caused by ciliary muscle and fibrosis. As such, the semi-rigid longitudinal tactile component 1 makes centering easier and achieves a more consistent placement with the optical components along the axis of the eye.

  In the intraocular lens embodiment described herein, the total length of the lens 100 is approximately 9. As measured diagonally across the lens from the tip 10 of the fixed soft lateral loop 6 on either side of the lens. It may be from 5 mm to about 12.0 mm, and from about 11.0 mm to about 14.0 mm. For example, refer to FIG. The transverse loop 6 may include a directing member 10 at the end of the transverse loop 6 (eg, a round or oval knob, one at each end of the securing member). The diagonal distance extends through the center of the optical component. The longitudinal length L (also shown in FIG. 3) of the lens 100 can be at least the diameter of the average lens capsule. For example, a preferred longitudinal length can be about 10.5 mm. When the length of the lens 100 is about 10.5 mm or less, the lens 100 does not deform the lens capsule and does not act on the ciliary muscle.

In some embodiments, the short optic extension 3 extending from the soft optic may be configured to be more rigid with its short length of less than 1 mm and its thickness.
As shown in FIG. 18A, the haptic component 1 includes a transverse member (or paddle as referred to elsewhere herein) 30 and a transverse bar 9 extending between the transverse extension members 30. obtain. The haptic component 1 can be wider than the optical component 2 (e.g., the lateral distance between the lateral extension members 30 on either side of the optical component compared to the width or diameter of the optical component). The tip 31 can be designed to be behind the optical component when implanted. Therefore, the transverse member 30 can be greatly curved toward the tip 31. The haptic component 1 may form a closed loop 12 (and an open area). The intraocular lens can include a short optical component extension 3 with a rigid bend joint 4 between the optical component 2 and the haptic component 1 between the ends of the extension. As described herein, the bending joint 4 can be arranged by tilting the haptic component with respect to the optical component at the time of manufacture. In some embodiments, the haptic component 1 partially surrounds the optical component by more than 180 ° of the outer periphery of the optical component. For example, a single haptic component may be at least 110 °, 120 °, 130 °, 140 °, 150 °, 160 °, or 170 ° of the outer periphery of the optical component, up to 175 ° or 180 °, or any in between Can surround the range.

  As shown in FIG. 18B, the tactile component 1 is a transverse member (or paddle) having an outer arch-shaped outer edge at the front end and parallel to the longitudinal length in the proximal direction with respect to the optical component. ) 30. The tactile component 1 can be made wider than the optical component by having the finger-like soft lateral extension 6. The transverse members 30 can be connected by a short optical component extension 3, between which the rigid bending joint 4 is between the optical component 2 and the tactile component 1. In some embodiments, the haptic component 1 partially surrounds the optical component by more than 180 ° of the outer periphery of the optical component. For example, a single haptic component may be at least 110 °, 120 °, 130 °, 140 °, 150 °, 160 °, or 170 ° of the outer periphery of the optical component, up to 175 ° or 180 °, or any in between Can surround the range.

9A-9D show a non-adjustable IOL comprising a soft optical component 2 having a rigid haptic component 1, which has two longitudinal directions extending from two laterally extending closed loops 31. FIG. With a chassis 104 having a rigid strut / plate 30, both closed loops are designed to secure and center the lens within the lens capsule. A tip bar 39 extends between the two struts / plates 30 to form an open area 32 surrounded by the center. Thus, various embodiments may include one, two, three, four, or more closed loops 31 (and open regions 32), at least a portion of the closed loop 31 being due to fibrosis Fixing may be facilitated. In some embodiments, as shown in FIGS. 9A-9D, the more central open area 32 is larger than any open area on either side of the central open area. The chassis 104 is partially embedded in the soft material 43 of the optical component. In various embodiments, the haptic component 1 is disposed at an angle with respect to the optical component 2. Line 107, which indicates the rigid bend joint 4 at the proximal end of the frame or chassis 104, indicates the tilted arrangement of the haptic component 1 at an angle with respect to the optical component 2, as described herein. However, in other embodiments, the design shown in FIGS. 9A-9D does not require the tactile component to be tilted with respect to the optical component during manufacturing and therefore need not include the rigid bend joint 4 as shown. Absent. The blind capsule of the capsular bag 33 is shown partially inflated to a radius of 11.5 mm.
Accommodating Lenses Although several embodiments have been described herein with reference to non-adjusting lenses, haptic components that can be combined with hinges or connecting bars can be used in accommodating lenses.

  Various embodiments of the haptic component described herein, including but not limited to those shown in FIGS. 6-9D, may be used in an adjustable lens. Additional information regarding connection bars and adjustable lenses can be found in US patent application Ser. No. 14 / 035,821, published as US 2014/0094909, filed Sep. 24, 2013 (“ Accommodating Intraocular Lens ") (Attorney Docket Number CORD.009P1), as well as US Patent Application No. 2015/0088254 filed September 24, 2013. No. 14 / 035,813 ("ANTERIOR CAPSULE DEFECTOR RIDGE") (Attorney Docket Number CORD. 010A), which is incorporated herein by reference in its entirety. , As part of this specification Should be considered.

  14A-14D show an example of an adjustable intraocular lens 200 having an optical component 202 and an opposing plate-type haptic component 214. The plate-type haptic component 214 can include a frame 222 embedded within the soft component 226. The frame 222 can include a through hole 230, and a flexible component 226 can extend through the through hole to secure the frame 222. The frame 222 may comprise polyimide, proline, polymethyl methacrylate (PMMA), titanium, or similar material. The soft component 226 may include silicone, hydrogel, acrylic, or similar material. In some cases, the soft component 226 and the optical component 202 can be constructed from the same material, for example acrylic.

  As shown in FIG. 14A, the frame 222 may extend outward beyond the proximal and distal edges of the soft component 226. The exposed edges of the frame 222 reduce the slipperiness of the adjustable intraocular lens (AIOL) 200 during implantation and facilitate implantation in the correct position. The frame 222 may include a number of openings 238 (eg, one, two, three, four, or more openings) at its distal portion. At least some of the openings 238 may be at least partially configured by a thin transverse bar 242 positioned at the tip of the haptic component 214. At least a portion of the opening 238 can extend beyond the leading edge of the soft component 226 so that fibrosis can occur around the thin transverse bar 242 and through the opening 238. Thus, as described above, various embodiments may include one, two, three, four, or more closed loops (and open regions 238), at least a portion of which is fixed by fibrosis. Can be encouraged. In some embodiments, as shown in FIGS. 14A-14D, the more central open area 238 is larger than any open area on either side of the central open area.

  The plate-type haptic component 214 is substantially soft in the transverse direction (eg, parallel to the x-axis) and substantially rigid in the longitudinal direction (eg, parallel to the y-axis). The plate-type haptic component 214 is sufficiently transversely soft to facilitate the insertion of the AIOL into the eye and contraction of the ciliary muscles, ie end-to-end compression. Can be sufficiently rigid in the longitudinal direction to withstand the eccentricity in response to.

  The proximal portion of each plate-type haptic component 214 can include opposing paddles 234 that at least partially surround the optical component 202. In various embodiments, for example, a single haptic component can surround at least 160 °, 170 ° to 175 ° or 180 ° of the outer periphery of the optical component, or any range therebetween, or optionally optical 110 °, 120 °, 130 °, 140 °, or 150 ° of the circumference of the part can encompass a maximum of 160 °, 170 °, or 180 °, or any range therebetween. The transverse width measured between the outer lateral edges of the paddle 234 can be greater than the transverse diameter of the optical component 202. The proximal portion of the paddle 234 can be spaced (eg, disconnected) from the optical component 202. Prior to implantation, the AIOL 202 can be manufactured in a substantially single plane. When the AIOL 200 is implanted in the eye such that at least the proximal portion of the paddle 234 is posterior to the optical component after implantation into the eye, the optical component 202 is arched rearward relative to the tip of the haptic component. Can turn to. When pushed backwards, the larger surface area of the paddle 234 may further increase the pressure behind the AIOL 200, thereby facilitating the movement of the optical component 202 in the forward direction when the ciliary body contracts. And the pressure of the fluid in the vitreous cavity is increased.

  Each of the opposing paddles 234 can include at least a portion of the frame 222 and at least a portion of the soft component 226. The portion of the frame 222 that makes up the paddle 234 can be larger than the portion of the soft component 226 that makes up the paddle 234. The portion of the frame 222 that forms the paddle 234 can be wider or longer than the portion of the soft component 226 that forms the paddle 234. As shown in FIG. 14A, in the paddle 234, the frame 222 extends laterally beyond the lateral edge of the soft component 226 and proximally beyond the proximal edge of the soft component 26.

  Each plate-type haptic component 214 can include a connection portion that can be connected to the optical component 202. The connection portion can include a short appendage 206 and a connection bar 210 (eg, a torsion bar) that extends laterally from the short appendage 206, for example, the connection bar 210 includes an opposing each of the short appendages 206. It can extend laterally from the side. Each haptic component 214 may include an elongated slot 218 that defines a through hole that may be distal to the short appendage 206 and the connection bar 210.

  The thickness of the connection bar 210 can be made thinner than that of the short appendage 206. The thickness of the connection bar 210 can be reduced so that the connection bar 210 can be stretched and / or rotated (eg, twisted) and the movement of the optical component 202 relative to the haptic component 214 is facilitated. Additional information regarding connection bars and adjustable lenses can be found in US patent application Ser. No. 14 / 035,821, published as US 2014/0094909, filed Sep. 24, 2013 (“ Accommodating Intraocular Lenses ") (Attorney Docket Number CORD.009P1), which is incorporated herein by reference in its entirety and as part of this specification. Should be considered.

  Each haptic component 214 may include one or more forward ridges 246 that extend forward from the haptic component 214. An exemplary ridge 246 is described in US patent application Ser. No. 14 / 035,813 (Attorney Docket No. CORD.010A) published as US Patent Application Publication No. 2015/0088254. Which is hereby incorporated by reference in its entirety and should be considered part of this specification. One or more forward ridges 246 may at least partially traverse one or both paddles 234 of each haptic component 214. As shown in FIG. 14A, a single forward ridged protrusion 246 can extend from one paddle 234 to the other paddle 234 of the same haptic component 214, thereby providing an arch shape. In FIG. 14A, the light and small spotted portion of the haptic component 214 is a frame 222, which may include polyimide. The dark area indicates the portion where the soft component 226 comprising, for example, silicone covers the frame 222. The darkest shaded area shows a ridge 246, which may include a thick area of soft material including a soft component 226 (eg, silicone). In this configuration, the forward ridge 246 can at least partially surround the elongated slot 218. 14B and 14D show a cross section of the ridged protrusion 246. FIG. One or more anterior ridges may separate AIOL 202 from the anterior capsule of the lens capsule of the human lens. FIG. 14C shows a frame 222 (dark and black area) that may include, for example, polyimide.

Such an accommodating intraocular lens may also have other features as described elsewhere herein.
Terminology As used herein, the relative terms “proximal” and “distal” are defined in terms of optical components. Therefore, the proximal end indicates the direction toward the optical component, and the distal end indicates the direction away from the optical component.

  As used herein, the term “fixed length” or “fixed longitudinal length” refers to a change in length of less than about 5% (eg, about 4%) when subjected to forces applied by the ciliary muscle after implantation. % Or less, about 3% or less, about 2% or less, or about 1% or less). For example, the soft finger 5 may bend in the center direction to fix the intraocular lens to the lens capsule (see FIG. 2). As used herein, the phrase “the vault angle can remain unchanged” means that the change is less than about 5% (eg, about 4%) when subjected to forces from ciliary muscle and fibrosis after implantation. % Or less, about 3% or less, about 2% or less, or about 1% or less).

  Conditional languages such as “can,” “could,” “might,” or “may” unless specifically stated otherwise Unless otherwise understood in the context as otherwise used, generally, a particular embodiment includes at least one of the particular features, elements, and steps, but other embodiments Communicate what is not. Therefore, such conditional language generally includes these features, whether at least one of the features, elements, and steps is included in or implemented in any particular embodiment. At least one of the features, elements, and steps is implied in some way necessary for one or more embodiments.

  As used herein, the terms “approximately”, “about”, and “substantially” represent an amount close to the stated amount that still performs the desired function or achieves the desired result. For example, in some embodiments, as may be indicated in context, the terms “approximately”, “about”, and “substantially” can refer to an amount in the range of 5% or less of the stated amount.

  The ranges disclosed herein also include any and all overlaps, subranges, and combinations thereof. Languages such as “maximum”, “at least”, “greater than”, “less than”, “between”, and the like include the listed numbers. Numbers preceded by a term such as “about” or “approximately” include the recited numbers. For example, “about 3 mm” includes “3 mm”.

  Although several embodiments and examples have been described herein, those skilled in the art will recognize that many aspects of the intraocular lens illustrated and described in this disclosure may be combined and modified differently and further It should be understood that other embodiments or acceptable examples may be formed. All such modifications and variations are intended to be included herein within the scope of this disclosure. A wide variety of designs and techniques are possible. Any feature, structure, or step disclosed herein is not essential or essential.

  Several embodiments have been described with reference to the accompanying drawings. However, it should be understood that the drawings are not to scale. The distances, angles, etc. are merely descriptions and do not necessarily relate exactly to the actual dimensions and layout of the depicted apparatus. Components can be added, removed or rearranged. Furthermore, the disclosure herein, such as any particular features, aspects, methods, properties, characteristics, qualities, characteristics, elements, etc., associated with the various embodiments is described in all other embodiments described herein. Can be used. Further, it can be appreciated that any method described herein may be implemented using any apparatus suitable for performing the recited steps.

  For purposes of this disclosure, certain aspects, advantages, and novel features are described herein. It should be understood that not all such advantages may be achieved in accordance with any particular embodiment. Thus, for example, this disclosure achieves one or a group of advantages as taught herein and not necessarily other advantages as may be taught or suggested herein. Those skilled in the art will recognize that it can be embodied or implemented.

  Furthermore, while exemplary embodiments have been described herein, any and all equivalent elements, modifications, omissions, combinations and adaptations (eg, of aspects across various embodiments), adaptations, and alterations are considered to be The scope of all embodiments is based on this disclosure, as will be appreciated by those skilled in the art. The limitation of the claims shall be construed broadly based on the language used in the claims and should not be limited to the examples described herein or during the performance of the application process. And these examples are to be interpreted as non-exclusive. Further, the acts of the disclosed processes and methods may be modified in any manner, including reordering of actions, insertion of additional actions, and deletion of actions. Therefore, the specification and examples are illustrative only, and the true scope and spirit is to be considered as being indicated by the following claims and their full scope of equivalents.

Claims (65)

Soft optical components,
At least one rigid plate-type haptic component connected to the optical component, wherein the at least one rigid plate-type haptic component has a rigid structure, and at least one rigid plate-type haptic component is The rigid plate-type haptic component that resists bending due to pressure applied to the tip of at least one of the haptic components by ciliary muscle contraction and fibrosis;
Including an intraocular lens,
The intraocular lens comprises a non-adjustable IOL having a fixed longitudinal length and configured to withstand the action of the ciliary muscle and deformation due to fibrosis .   The intraocular lens according to claim 1, wherein the at least one rigid haptic component is rigid in the longitudinal direction and soft in the transverse direction.   The intraocular lens according to claim 1 or 2, wherein at least one rigid haptic component further comprises a soft material, and the hard structure is at least partially embedded in the soft material.   The intraocular lens according to claim 3, wherein the soft material and the optical component comprise the same material.   The intraocular lens according to claim 3 or 4, wherein the soft material includes silicone or acrylic.   The intraocular lens according to claim 1 or 2, wherein the hard structure is connected to the optical component by a short and thick hard extension of the soft optical component.   The intraocular lens according to claim 1, wherein the soft optical component and at least one rigid plate-type haptic component comprise the same material.   The intraocular lens according to claim 1, wherein the hard structure includes at least one support column extending in a vertical direction.   The intraocular lens of claim 8, wherein the rigid structure further comprises a loop structure that at least partially surrounds at least one of the longitudinally extending struts to form at least one open region.   The intraocular lens according to claim 9, wherein the loop structure has a width shorter than a width of at least one of the support columns extending in a vertical direction.   The intraocular lens according to any one of claims 1 to 8, wherein the hard structure includes a laterally extending portion at a distal end portion thereof and forms a T shape.   The intraocular lens according to any one of claims 1 to 8 and claim 11, wherein the hard structure includes a thin bar disposed at a tip portion thereof.   The intraocular lens according to claim 12, wherein the plate-type tactile component further includes an open region surrounded in a proximal direction of the thin bar.   The intraocular lens according to claim 1, wherein the optical component is tilted rearward before being inserted into the eye.   The intraocular lens according to claim 1, wherein the optical component is arranged to be tilted forward at a fixed angle with respect to each plate-type tactile component before being inserted into the eye. Lens optics,
A pair of opposing plate-type haptic components coupled to the lens optic;
An adjustable intraocular lens comprising:
Each plate-type haptic component comprises a rigid frame at least partially embedded in a soft component, the rigid frame having a number of openings along the distal end portion of the frame, and at least some of the openings At least a portion of which extends beyond the leading edge of the soft component, and the transverse width of the rigid frame measured between opposing transverse edges of the rigid frame is the opposite transverse width of the flexible component. An accommodating intraocular lens that is greater than a transverse width of the soft component measured between directional edges and wherein the rigid frame extends beyond a proximal edge of the soft component.   The accommodation type intraocular lens according to claim 16, wherein each plate-type tactile component includes a connection portion connected to the optical component.   18. The adjustable intraocular according to claim 17, wherein the connection portion comprises a short appendage connected to the optical component and at least one connection bar extending laterally from the short appendage. lens.   At least one of the connection bars includes a first connection bar and a second connection bar, the first connection bar and the second connection bar extending laterally from opposite sides of the short appendage The adjustable intraocular lens according to claim 18.   The accommodation type intraocular lens according to any one of claims 16 to 19, further comprising an elongated slot.   21. The accommodation type intraocular lens according to any one of claims 16 to 20, wherein the accommodation type intraocular lens further comprises at least one front projection extending forward from each of the plate-type tactile components.   17. Each plate-type haptic component comprises opposing lateral paddles, and the transverse width measured between the outer lateral edges of the paddle on the same haptic component is wider than the transverse width of the optical component. The accommodation type intraocular lens of any one of -21. A single-focus, semi-rigid acrylic optical component configured to bend back in an arch shape; and
At least one semi-rigid acrylic plate-type haptic component connected to the optical component;
Including an intraocular lens,
The intraocular lens has a fixed longitudinal length that is fixed, and the intraocular lens is configured to provide naked eye vision at near, intermediate, and far distances.   24. The intraocular lens of claim 23, wherein the semi-rigid haptic component is sufficiently soft to be compressed from an original configuration to a compressed configuration for insertion into the eye through a small incision.   25. The intraocular lens of claim 24, wherein the intraocular lens can assume the original configuration after implantation into the eye.   26. The optical component according to any one of claims 23 to 25, wherein the optical component is configured to arch backward at a fixed angle with respect to at least one of the haptic components, and the vault angle does not change after implantation in the eye. The intraocular lens according to item 1.   27. The intraocular lens according to any one of claims 23 to 26, wherein at least one of the tactile components is disposed to be tilted forward with respect to the optical component.   The intraocular lens according to any one of claims 23 to 27, wherein the at least one haptic component includes two haptic components, and the two haptic components are arranged to be tilted forward.   27. The intraocular lens of claim 26, wherein the vault angle is between about 1 degree and about 50 degrees.   30. The intraocular lens of claim 29, wherein the vault angle is from about 5 degrees to about 40 degrees.   31. The intraocular lens according to any one of claims 23 to 30, wherein the at least one semi-rigid haptic component further comprises an enclosed open area that is at least partially constituted by a thin bar.   32. The intraocular lens according to any one of claims 23 to 31, wherein the last one semi-rigid haptic component further comprises at least one lateral extension extending from a tip of the haptic component.   At least one semi-rigid haptic component comprises a single longitudinal plate that extends laterally from the proximal end of the plate to the distal end of the plate to form at least one open region 35. The intraocular lens according to any one of claims 23 to 32, having at least one soft finger loop.   34. The intraocular lens of claim 33, wherein at least one of the open areas includes two or three open areas.   35. The intraocular lens according to any one of claims 23 to 34, wherein at least one semi-rigid haptic component is connected to the optical component by a semi-rigid extension of the optical component. A single-focus optical component configured to be tilted backwards;
At least one semi-rigid haptic component connected to the optical component;
A non-adjustable intraocular lens comprising:
The optical component is bent into an arch shape at a fixed angle with respect to at least one of the tactile components before surgery, the optical component remains bent in an arch shape after implantation, and the intraocular lens is A non-accommodating intraocular lens configured to provide naked eye vision at distance, intermediate distance, and distance.   38. The non-adjustable intraocular lens of claim 36, wherein the semi-rigid haptic component is sufficiently soft to be compressed from an original configuration to a compressed configuration for insertion into the eye through a small incision.   38. The non-adjustable intraocular lens of claim 37, wherein the intraocular lens can assume the original configuration after implantation into the eye.   39. The non-adjustable intraocular lens according to any one of claims 36 to 38, wherein at least one of the tactile parts is tilted forward.   40. The non-adjustable intraocular lens according to any one of claims 36 to 39, wherein at least one of the haptic components includes two haptic components, and the two haptic components are tilted forward.   41. The non-adjustable intraocular lens according to any one of claims 36 to 40, wherein the vault angle is about 1 to 50 degrees.   42. The non-accommodating intraocular lens according to any one of claims 36 to 41, wherein the optical component and the at least one haptic component comprise the same material.   43. The non-accommodating intraocular lens according to claim 42, wherein the same material is acrylic. Single-focus acrylic optical components,
At least one acrylic tactile component connected to the optical component;
A non-adjustable intraocular lens comprising:
The lens optic is manufactured at a fixed angle with respect to at least one of the haptic components and is bent back arched, the optic remains bent in arch after implantation; The intraocular lens is configured to provide naked eye vision at near, intermediate, and far distances;
The intraocular lens is a non-adjustable intraocular lens having a fixed longitudinal length that is fixed regardless of ciliary muscle contraction and fibrosis.   45. The non-adjustable intraocular lens according to claim 44, wherein the at least one haptic component is tilted forward.   46. The non-adjustable intraocular lens according to claim 44 or 45, wherein at least one of the haptic components includes two haptic components, and the two haptic components are tilted forward.   47. The non-adjustable intraocular lens according to any one of claims 44 to 46, wherein the vault angle is from about 1 degree to about 50 degrees.   48. The non-adjustable intraocular lens of claim 47, wherein the vault angle can be between about 5 degrees and about 50 degrees.   49. The non-adjustable intraocular lens according to any one of claims 44 to 48, wherein the vault angle does not change after implantation.   44. The non-adjustable intraocular lens according to any one of claims 36 to 43, wherein the vault angle does not change after implantation.   The intraocular lens according to claim 7, wherein the intraocular lens generally comprises the same material.   52. The intraocular lens according to claim 7 or 51, wherein the intraocular lens comprises a monolith structure.   53. The intraocular lens according to any one of claims 7, 51, and 52, wherein the material comprises acrylic.   The intraocular lens according to claim 1, wherein the material of the soft optical component includes acrylic.   The intraocular lens according to claim 1, wherein the hard optical component includes acrylic.   6. The intraocular lens according to any one of claims 3, 4, and 5, wherein the rigid structure extends beyond the soft material.   At least one rigid plate-type haptic component includes a first plate-type haptic component and a second plate-type haptic component, and the first plate-type haptic component includes the optical component and the first plate-type haptic component. The second tactile component is coupled to the optical component at a non-zero first set angle between the component and the second tactile component is not zero between the optical component and the second plate-type tactile component 57. Any of claims 1-15 and 51-56, wherein the second angle that is coupled to the optical component at a second set angle is different from the first non-zero angle. The intraocular lens according to claim 1.   The lens is configured such that when the intraocular lens is placed in the lens capsule of the eye, the upper hemisphere of the optical component is positioned at 12 o'clock and rearward relative to the lower hemisphere. 58. The intraocular lens of claim 57.   59. The intraocular lens of claim 58, wherein the upper hemisphere is configured to focus light for distance vision.   58. The intraocular lens of claim 57, wherein the first non-zero angle is not less than 10 degrees and not more than 50 degrees.   61. The intraocular lens of claim 57 or 60, wherein the second non-zero angle is at least about 20 degrees and no more than about 50 degrees.   62. The intraocular according to any one of claims 1 to 15 and 51 to 61, wherein the hard structure is connected to the optical component by a short and thick hard extension of the soft optical component. lens.   63. The intraocular lens according to any one of claims 1 to 15 and 51 to 62, wherein the rigid structure comprises a curved loop comprising the same material as the optical component, the material comprising acrylic.   The intraocular lens according to claim 9, wherein the at least one open region comprises two or three open regions.   58. The first haptic component is disposed to be tilted forward with respect to the optical component, and the second haptic component is disposed to be tilted rearward with respect to the optical component. 61. The intraocular lens according to any one of 61.