JP2017178809A - Hdl cholesterol increasing agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an HDL cholesterol increasing agent for improving dyslipidemia.SOLUTION: An HDL cholesterol increasing agent comprises Geranium dielsianum, a plant of Geraniaceae growing naturally in cold and vast uplands of the Andes in Peru, or extract powder thereof.SELECTED DRAWING: None

Description

  The present invention relates to an HDL cholesterol raising agent comprising Geranium dielsianum.

  Geranium dielsianum is a plant belonging to the family Aceraceae that grows naturally in the cold and vast highlands of the Andes in Peru, South America.

  Geranium dielsianum is a popular herb with many excellent medicinal properties such as anti-diabetic action, suppression of throat inflammation, and healing of stomatitis among indigenous peoples in the Central Andes region.

  To date, most of the functionality of Geranium dielsianum has been reported in in vitro and in vivo studies, and there have been few reports on human studies, and there is insufficient information to clarify the physiological actions of Geranium dielsianum.

  The present invention provides a novel HDL cholesterol raising agent.

As a result of diligent efforts, the present inventor has surprisingly found for the first time that Geranium dielsianum increases HDL cholesterol, and has completed the present invention.
Therefore, the present invention is as follows.
[1] An HDL cholesterol-elevating agent comprising Geranium dielsianum.
[2] The HDL cholesterol elevating agent according to [1], wherein the geranium diercianum is a geranium diercianum extract powder.

  The present invention can increase HDL cholesterol in women suffering from rough skin due to a tendency to constipation.

  Geranium dielsianum is a plant belonging to the family Aceraceae that grows naturally in the cold and vast highlands of the Andes in Peru, South America.

  Geranium dielsianum is a popular herb with many excellent medicinal properties such as anti-diabetic action, suppression of throat inflammation, and healing of stomatitis among indigenous peoples in the Central Andes region.

  The extract powder of Geranium dielsianum is marketed as Miskamisuka (registered trademark) and is used in supplements and beverages. However, there is no report of the health damage. In Peru, the country of origin of Geranium dielsianum, it has long been used as a traditional medicine that has no toxicity and no side effects, such as boiled or tea.

  HDL cholesterol is called “good cholesterol” because it plays a role in transporting excess cholesterol in the blood to the liver, so to speak, it prevents the blood cholesterol from increasing. In order to improve dyslipidemia, particularly HDL cholesterolemia, a diet that increases HDL cholesterol is recommended.

  The HDL cholesterol raising agent according to the present invention can be used as food or animal feed, for example, as health food, functional food, health supplement, specified health food, beauty food, or nutritional supplement (supplement). it can. These foods and animal feeds may be in the form of, for example, drinking water such as tea and juice; and ice cream, jelly, candy, chocolate, chewing gum and the like. Moreover, the form of a liquid agent, a powder agent, a granule, a capsule, or a tablet may be sufficient.

  The composition concerning this invention can be used as a pharmaceutical or a quasi-drug. These drugs or quasi drugs can be administered orally, for example, in the form of powders, tablets, coated tablets, dragees, hard or soft gelatin capsules, solutions, emulsions, or suspensions. Rectally in the form of an agent; eg, in the form of an injection or infusion; locally or transdermally, eg, in the form of an ointment, cream, gel, or solution; eg, in the form of eye drops and eyewash It can also be administered topically to the eye; parenterally. Oral administration is preferred.

  When the composition of the present invention is used in the form of tablets, granules, or capsules, tableting aids, granule processing aids, capsule processing aids and the like can be used.

  The tableting processing aid is not particularly limited as long as it does not impair the effects of the present invention, and is any granulated sugar, super white sugar, powdered sugar, reduced maltose starch syrup, lactose, glucose, pullulan, erythritol, starch, dextrin, etc. Surfactant, powder such as sugar, crystalline cellulose, gum arabic, okara, etc., dietary fiber such as corn protein, calcium phosphate, food extract, food dry powder, natural fruit juice powder, sucrose fatty acid ester Fats and oils such as fats and oils, glycerin and fatty acid esters, or various sweeteners used in chewable tablets (eating tablets), various acidulants and various flavorings, shellac as a coating material, corn protein, yeast cell wall, starch , Reduced maltose starch syrup, sugarless sugar coating, maltitol, g Serine, sorbitol, HPMC, HPC and the like are exemplified.

  The granule processing aid is not particularly limited as long as the effects of the present invention are not impaired, and any sugar such as granulated sugar, super white sugar, powdered sugar, reduced maltose starch syrup, lactose, glucose, pullulan, erythritol, starch, dextrin, etc. Examples thereof include dietary fibers such as crystalline cellulose and gum arabic, food calcium such as corn protein and calcium phosphate, food extracts, food dry powders, and natural fruit juice powders.

  The capsule processing aid is not particularly limited as long as the effects of the present invention are not impaired. Granulated sugar, fine white sugar, powdered sugar, reduced maltose starch syrup powder, lactose, glucose for preparing hard capsule type capsules , Pullulan, erythritol, starch, dextrin and other sugars, crystalline cellulose, dietary fiber such as gum arabic, food calcium such as corn protein and calcium phosphate, food extracts, food dried powders, natural fruit juice powder, etc., soft capsule type For example, content viscosity modifiers such as food fats and oils, beeswax, glycerin fatty acid esters, and the like for preparing capsules are exemplified.

  Tablets can usually be prepared using a tableting machine, but the tablets are blended with seasoning ingredients to make a chewable tablet, or the tablet surface is coated using an automatic coating machine, spray granulator or hand pan. Or you may. Various types of granulators such as a spray granulator type, a kneading (extruding) type, or a high-speed agitation granulator type can be used for forming the granule. For preparation of capsules, capsule filling machines (hard type and soft type) can be used by mixing capsule aids.

The amount of intake of the composition according to the present invention is not particularly limited, but can be appropriately selected according to the dosage form and the age, weight and symptoms of the intake person or intake animal such as the user or patient. For example, about 0.01 g to about 50 g, preferably about 0.2 g to about 10 g, more preferably about 0.3 g to about 6 g, is taken orally per day as the amount of active ingredient per 60 kg body weight of the ingestor or ingestion animal. It is preferable.
The intake period can be arbitrarily determined according to the age and symptoms of the intake person or animal.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

Twelve subjects were analyzed. The participants' participation criteria are as follows.
1. Healthy Japanese women aged 30 to under 50
2. If you like sweets and carbohydrates,
3. If you suffer from constipation,
4). If you are worried about rough skin,

The composition (per 8 grains) of the test food is as follows.
Active ingredient Misukamisuka (registered trademark) (Geranium dielsianum extract powder) 1,200 mg
Excipient crystalline cellulose, calcium stearate 800mg

  Subjects took the test food twice a day for 12 weeks, 4 after breakfast and after dinner. In addition, even when the meal was not taken, only the test food was taken. In the unlikely event that loose stool or diarrhea symptoms occurred due to the intake of the test food, the intake was adjusted by the investigator.

Blood tests were performed before ingestion and 12 weeks after ingestion. The inspection items are as follows.
Hematological examination: white blood cell count, white blood cell count, red blood cell count, hemoglobin content, hematocrit value, average red blood cell volume, average red blood cell hemoglobin content, average red blood cell pigment concentration, platelet count General biochemical test ... T-bil, AST, ALT, ALP , LDH, γ-GTP, CPK, TP, Alb, A / G ratio, creatinine, uric acid, urea nitrogen, TG, T-cho, HDL-cho, LDL-cho, Na, K, Cl, Ca, Fe, blood glucose , HbA1c

  In comparison before and after ingestion, HDL cholesterol was significantly improved (p = 0.034). While it was 66.33 ± 14.66 before ingestion, it increased to 71.60 ± 12.72 after 12 weeks of ingestion. All other changes observed were within the threshold. There were no serious adverse events during and after the study.

Claims (2)

An HDL cholesterol-elevating agent, including Geranium dielsianum. The HDL cholesterol raising agent according to claim 1, wherein the geranium diercianum is a geranium diercianum extract powder.