JP2017144252A - Diagnostic system of presence/absence of mild cognitive dysfunction, terminal for cognitive function examination, and program for cognitive function examination - Google Patents

Abstract

PROBLEM TO BE SOLVED: To diagnose presence/absence of the mild cognitive dysfunction by comprehensively examining the cognitive function of a subject and taking account of the age of the subject.SOLUTION: The diagnostic system of presence/absence of the mild cognitive dysfunction includes: means (32) for acquiring examination data related to respective examinations of an examination of a logical immediate memory, an examination of visuospatial cognition ability, an examination of immediate memory of words, an examination of cognitive function including orientation faculty, memory skill, calculation ability, language ability, and graphic ability, an examination of attentional function, an examination of performance function, an examination of information processing ability, an examination of suppressive function, an examination of delayed reproduction function of words, and examination of logical delayed recognition function; means (31) for acquiring age data of the subject; and means (22) for collating examination data of at least one examination of the examinations with examination data obtained by performing the at least one examination for a plurality of persons of an age layer corresponding to the age data and diagnosing whether or not the subject has the mild cognitive dysfunction.SELECTED DRAWING: Figure 3

Description

  The present invention relates to a diagnostic system, a cognitive function testing terminal, and a cognitive function testing program for diagnosing the presence or absence of mild cognitive impairment.

  Mild cognitive impairment (MCI) is a disease in which a decline in cognitive function, which cannot be said to be normal compared to age, is recognized, although it is not dementia. Elderly people with MCI are said to have a higher risk of transitioning to Alzheimer's disease, which is known as the main disease of dementia, compared to elderly people with normal cognitive function. On the other hand, it is reported that about 20 to 30% of elderly people with MCI recover their cognitive function to normal after several years. Early detection of MCI is required to prevent dementia.

  Patent Documents 1 and 2 are known as techniques for examining the cognitive function. Patent Document 3 discloses a diagnostic technique for finding a suspicion of Alzheimer's disease.

JP 2011-255106 A JP 2005-137629 A JP 2010-187959 A

  In order to diagnose the presence or absence of MCI, it is necessary to comprehensively examine the cognitive function from various aspects such as memory ability, attention function, performance function, visuospatial cognitive ability, and information processing ability. In addition, an objective diagnostic criterion considering the age of the subject is also required.

  In this regard, according to the techniques disclosed in Patent Documents 1 and 2, although a part of the cognitive function can be examined, it is difficult to perform a comprehensive cognitive function test necessary for the diagnosis of the presence or absence of MCI. . Further, the seven simple questions disclosed in Patent Document 3 do not include a question for directly evaluating cognitive function, and it is difficult to diagnose the presence or absence of MCI.

  Therefore, the disclosed content of the present application aims to comprehensively examine the cognitive function of a subject and objectively diagnose the presence or absence of MCI in consideration of the age of the subject.

  In order to achieve the above object, the diagnosis system for the presence or absence of mild cognitive impairment disclosed in the present application includes a first test that is a test of logical immediate memory ability and a second test that is a test of visuospatial cognitive ability. And a third test, which is a test of the immediate memory ability of words, a fourth test, which is a test of cognitive function including orientation, memory, computation, linguistic and graphic skills, and an attention function test. A fifth test, a sixth test that is a test of performance function, a seventh test that is a test of information processing capability, an eighth test that is a test of suppression function, and a test of delayed reproduction ability of words Cognitive function test means for acquiring test data of a subject for each test of 9 tests and the 10th test that is a test of logical delayed recognition ability, age data acquisition means for acquiring age data of the test subject, Obtained by the cognitive function testing means. The test data of at least one of the first test to the tenth test of the person is the at least one test for a plurality of persons in the age group corresponding to the age data acquired by the age data acquisition means Diagnostic means for diagnosing whether or not the subject has mild cognitive impairment in comparison with examination data obtained by examination.

  More specifically, the diagnostic means includes the test data of the at least one test of the subject, and an average value and standard deviation of test data obtained by performing the at least one test on the plurality of persons. Based on the diagnosis.

  In order to achieve the above object, a terminal for cognitive function test disclosed in the present application includes a first test that is a test of logical immediate memory ability, a second test that is a test of visual space cognitive ability, A third test, which is a test of immediate memory ability, a fourth test, which is a test of cognitive function including orientation, memory, computing power, linguistic ability, and graphic ability, and a fifth test, which is a test of attention function A sixth test that is a test of execution function, a seventh test that is a test of information processing ability, an eighth test that is a test of suppression function, a ninth test that is a test of delayed reproduction ability of words, Cognitive function test means for acquiring test data of a subject for each test with the tenth test that is a test of logical delayed recognition ability, age data acquisition means for acquiring age data of the test subject, and the cognitive function test means Acquired the first examination of the subject The test data of at least one of the tenth tests is obtained by performing the at least one test on a plurality of persons in an age group corresponding to the age data acquired by the age data acquisition means. Examination of at least one of the tenth examinations from the first examination to the diagnostic server for diagnosing whether or not the subject has mild cognitive dysfunction against the examination data Data transmitting means for transmitting data and the age data, and data receiving means for receiving a diagnosis result from the diagnosis server.

  In more detail, the diagnostic server includes the test data of the at least one test of the subject, and an average value and a standard deviation of test data obtained by performing the at least one test on the plurality of persons. Based on the diagnosis.

  In order to achieve the above object, the cognitive function testing program disclosed in the present application includes a first test that is a test of logical immediate memory ability, a second test that is a test of visual space cognitive ability, A third test, which is a test of immediate memory ability, a fourth test, which is a test of cognitive function including orientation, memory, computing power, linguistic ability, and graphic ability, and a fifth test, which is a test of attention function A sixth test that is a test of execution function, a seventh test that is a test of information processing ability, an eighth test that is a test of suppression function, a ninth test that is a test of delayed reproduction ability of words, A cognitive function test process for acquiring test data of a subject for each test with the tenth test, which is a test of logical delayed recognition ability, an age data acquisition process for acquiring age data of the test subject, and the cognitive function test process Of the subject obtained by The inspection data of at least one of the tenth examination from the first examination to the at least one examination for a plurality of persons in an age group corresponding to the age data acquired by the age data acquisition process At least one of the first examination to the tenth examination of the subject toward a diagnostic server for diagnosing whether or not the subject has mild cognitive impairment in comparison with examination data obtained by performing The cognitive function test terminal is caused to execute a data transmission process for transmitting test data of one test and the age data, and a data reception process for receiving a diagnosis result from the diagnostic server.

  In more detail, the diagnostic server includes the test data of the at least one test of the subject, and an average value and a standard deviation of test data obtained by performing the at least one test on the plurality of persons. Based on the diagnosis.

  According to the disclosure of the present application, it is possible to comprehensively examine the cognitive function of a subject and objectively diagnose the presence or absence of MCI in consideration of the age of the subject.

It is explanatory drawing which shows the whole structure of a diagnostic system. It is explanatory drawing which shows the hardware structural example of the terminal for a test | inspection. (A) It is explanatory drawing which shows the function structural example of a diagnostic server. (B) It is explanatory drawing which shows the function structural example of the terminal for a test | inspection. It is a flowchart which shows the detail of a process of the terminal for an inspection. It is explanatory drawing which shows an example of a basic information input screen. It is explanatory drawing which shows an example of a test content description screen. It is explanatory drawing which shows an example of a practice screen. It is explanatory drawing which shows an example of a data preservation | save screen.

[1. Diagnostic system]
FIG. 1 shows an overview of a diagnostic system 1 for diagnosing the presence or absence of MCI. The diagnostic system 1 includes a diagnostic server 2 and an inspection terminal 3. The inspection terminal 3 is a portable terminal that is operated by the subject himself / herself who undergoes a cognitive function test, and performs processing for receiving the input by the operation and testing the subject's cognitive function. The inspection terminal 3 is connected to the diagnostic server 2 through the network 4. Thereby, the terminal 3 for a test | inspection can transmit the test | inspection data of the said test subject's cognitive function to the diagnostic server 2. FIG.

  Connected to the diagnostic server 2 is a database 5 for storing inspection data received from the inspection terminal 3. Further, the database 5 stores in advance past inspection data for more than 5000 people. The number of 5000 people is just an example. The diagnosis server 2 diagnoses whether the subject has MCI based on the examination data of the subject received from the examination terminal 3 and the past examination data stored in the database 5; The diagnosis result can be transmitted to the inspection terminal 3.

  FIG. 2 shows a hardware configuration example of the inspection terminal 3. The inspection terminal 3 includes a CPU 301, an interface device 302, an input and display device 303, an auxiliary storage device 305, a memory device 306, a microphone 307, and a speaker 308, which are connected to each other via a bus 310. It is connected to the.

  The interface device 302 is used as an interface for connecting to the diagnostic server 2 through the network 4. A program for realizing the inspection function of the inspection terminal 3 can be downloaded from the diagnosis server 2 or another computer (not shown) via the network 4. The auxiliary storage device 305 stores programs installed after the download, and stores necessary files, data, and the like.

  The memory device 306 reads the program from the auxiliary storage device 305 and stores it when there is an instruction to start the program. The CPU 301 realizes the function of the inspection terminal 3 according to a program stored in the memory device 306. The input and display device 303 is a device that receives a command from the program and displays a screen for examining the cognitive function on the touch panel 3031 (not shown in FIG. 2) and accepts an input by operating the touch panel 3031. The microphone 307 is a device that converts sound uttered by the subject into an electrical signal. The speaker 308 is a device that outputs sound in response to an instruction from the program.

  The diagnostic server 2 has the same hardware configuration as that of the inspection terminal 3.

  FIG. 3 shows a functional configuration example of the inspection terminal 3 and the diagnostic server 2. First, as shown in FIG. 3A, the testing terminal 3 includes basic information acquisition means 31, cognitive function testing means 32, and data transmission / reception means 33. The basic information acquisition unit 31 is a unit that receives basic information such as the date of birth and sex of the subject input by the subject using the touch panel 3031. The cognitive function inspecting means 32 is a means for displaying a question for the subject for inspecting the cognitive function on the touch panel 3031 and receiving an input result of the subject for the question. The data transmitting / receiving unit 33 is a unit that transmits the test subject input results received by the basic information acquiring unit 31 and the cognitive function testing unit 32 to the diagnostic server 2 and receives data from the diagnostic server 2.

  As shown in FIG. 3B, the diagnosis server 2 includes a data transmission / reception means 21 and a diagnosis means 22, and a database 5 is connected to the diagnosis means 22. The data transmitting / receiving means 21 is means for receiving data from the inspection terminal 3. The diagnosis unit 22 diagnoses whether or not the subject has MCI based on the test data of a subject received by the data transmitting / receiving unit 21 and the past test data stored in the database 5. The diagnosis result by the diagnosis means 22 is sent to the inspection terminal 3 through the data transmission / reception means 21.

  Further detailed functions of the respective means described so far with reference to FIG. 3 will be described later.

[2. Processing performed by inspection terminal]
Next, the flow of processing performed by the inspection terminal 3 will be described with reference to FIG. First, the basic information acquisition unit 31 displays a basic information input screen for acquiring the basic information on the touch panel 3031. An example of this basic information input screen is shown in FIG. As shown in the figure, the basic information input screen includes a personal ID input field M31, a receipt number input field M32, a date of birth input field M33, a gender input field M34, an education year input field M35, and a confirmation button. M36. Furthermore, the date of birth input field M33 includes a year input field M33a, a year input field M33b, a month input field M33c, and a date input field M33d. When the subject inputs data in each input field and presses the confirm button M36, the basic information acquisition unit 31 stores the input basic information data in the memory device 306. The above is step S101.

  Next, the process proceeds to step S200. In step S <b> 200, processing for examining the cognitive function of the subject is performed by the cognitive function testing means 32. Step S200 includes steps S201 to S210. Thereby, a test subject's cognitive function can be examined comprehensively from various aspects.

  In step S201, the logical immediate storage capability is checked. The logical immediate memory ability is characterized by a decline in the elderly with MCI. In addition, among MCI, amnestic MCI, whose memory ability including logical memory is reduced, is considered to have a high risk of transition to Alzheimer's disease.

  As specific examination contents, the subject listens to the story for about 1 minute, and after having learned the contents, 10 questions are asked and the answer that matches the contents of the story is selected. This test is valid with the immediate memory test (Logical Memory-I) included in the revised Wechsler Memory Scale-Revised (WMS-R), which is also used internationally as a test for logical memory capacity. Has been confirmed. The highest score is 10 points and the lowest score is 0 points.

  In step S201, the cognitive function test means 32 reproduces the voice that has infused the story in order to check such a logical immediate memory ability. The reproduced sound is output from the speaker 308 or from a headphone (not shown) connected to the inspection terminal 3. Subsequently, the cognitive function inspecting means 32 displays on the touch panel 3031 10 questions that ask the content of the story. The answer input by the subject is received and scored by the cognitive function testing means 32, and the scored result is stored in the memory device 306.

  In step S202, the visual space recognition ability is examined. This decline in visuospatial cognitive ability is considered as one of the characteristics of elderly people with MCI. As specific inspection contents, the same figure as the sample figure displayed on the touch panel is selected from three choices displayed in another area of the touch panel. Nine questions are prepared for this examination, and the number of correct answers is calculated. This test has been confirmed to be valid with the Block Design test, which is a subordinate item of the Wexler Adult Intelligence Scale III (WAIS-III).

  In order to test this visual space cognitive ability, in step S202, the cognitive function testing means 32 displays a sample figure on the touch panel 3031 and also displays three options on the touch panel 3031. Then, the cognitive function inspection means 32 receives the test subject's answer and determines whether or not the answer is correct. Such processing is performed for each of the nine questions. Thereafter, the cognitive function testing unit 32 calculates the number of correct answers and stores it in the memory device 306.

  In step S203, the subject's immediate memory ability is checked by storing the word. This decline in memory ability is one of the core symptoms of Alzheimer's disease and MCI, and is known to be associated with atrophy of the hippocampus that controls memory. As test contents, 10 words displayed on the touch panel at a frequency of 1 every 2 seconds are memorized by the subject, and 10 words are stored from a list of 30 words displayed immediately after that. Let the subject select. The same examination is repeated three times, the number of correct answers for each time is calculated, and then the average number of correct answers for three times is calculated. The highest score is 10 points and the lowest score is 0 points. This test confirms the validity of the 12 word recognition task, which is a subordinate evaluation scale of the Alzheimer's Disease Assessment Scale-Cognitive sub-scale (ADAS-cog). Has been.

  In order to perform the above-described test, in this step, the cognitive function test means 32 displays a total of 10 words on the touch panel 3031 at a frequency of 1 every 2 seconds, and then includes a total of 30 words including those 10 words. A list of words is displayed, the selection result of the subject is accepted, and the number of correct answers is calculated. Repeat three times. Thereafter, the cognitive function testing means 32 calculates the average number of correct answers for three times and stores it in the memory device 306.

  In step S204, general cognitive functions including orientation, memory, calculation, linguistic ability, and graphic ability are examined. Specifically, Mini-Mental State Examination (MMSE), which is widely used internationally, is used. It consists of 11 questions, with the lowest score being 0 points and the highest score being 30 points. This test is also internationally standardized and is very frequently used in clinical practice. Normally, this inspection requires paper and writing tools, but in this embodiment, it can be performed paperless using the inspection terminal 3 and can be scored immediately.

  In this step, the cognitive function testing means 32 displays each of the 11 questions on the touch panel 3031 and accepts the test subject's answer in order to perform the mini mental state test. Then, the cognitive function testing unit 32 performs scoring and stores the scoring result in the memory device 306.

  In step S205, the attention function is inspected. Here, an improved version of Trail Making Test Part A is used. Specifically, this is an examination in which the subject taps sequentially from “1” in a state where numbers from “1” to “15” are displayed at random positions on the touch panel. The time limit is 90 seconds, and the time required to complete the inspection is measured. Time measurement starts simultaneously with the start of the inspection, and when the last number “15” is selected, the time measurement is completed and the required time is recorded.

  In this step, the cognitive function testing means 32 displays the numbers from “1” to “15” at random positions on the touch panel 3031 and simultaneously starts time measurement in order to perform such attention function testing. To do. And the cognitive function test | inspection means 32 receives the selection result of the number from a test subject. The cognitive function testing unit 32 ends the time measurement when the number “15” is selected, and stores the required time in the memory device 306.

  In step S206, the performance function is inspected. This performance function is considered to be one of the functions that decline in elderly people with MCI. And the decline in executive function is also related to the decline in walking function in the elderly.

  For the inspection, an improved version of Trail Making Test Part B is used. Specifically, in a state where 8 numbers from “1” to “8” and 7 hiragana from “a” to “ki” are displayed at random positions on the touch panel, This is an inspection in which numbers and hiragana are alternately selected in the order of numbers → Hiragana → Numbers → Hiragana →... Starting from the number “1”. The numbers are selected in ascending order, and hiragana is selected in alphabetical order. Therefore, the correct order is “1” → “A” → “2” → “I” → “3” →... → “7” → “ki” → “8”. The time required until the last number “8” is selected after the eight numbers and the seven hiragana characters are displayed on the touch panel is recorded. The time limit is 90 seconds.

  In this step, the cognitive function test means 32 displays the eight numbers and the seven hiragana characters at random positions on the touch panel 3031 and simultaneously measures time in order to perform the test of the performance function. To start. And the cognitive function test | inspection means 32 receives the selection result of the number and hiragana from a test subject. The cognitive function testing unit 32 ends the time measurement when the number “8” is selected, and stores the required time in the memory device 306.

  In step S207, the information processing capability is inspected. Here, an improved sign test is used. Specifically, as shown in FIG. 6, while looking at the display M41 of the correspondence relationship between the numbers ("1" to "9") and the symbols ("x", "-", etc.) The number corresponding to the symbol displayed in the area M43 is selected from the number list M44 from “1” to “9”. FIG. 6 is an examination content explanation screen, and a display M42 for explaining the examination content is also displayed. Subsequently, a practice screen as shown in FIG. 7 is displayed, and the subject is made to practice the examination. Thereafter, an actual inspection is performed with a time limit of 90 seconds. The symbols displayed in the area M43 are sequentially changed, and the subject is asked to select a number from the number list M44 each time. Ask as many answers as possible within the time limit, and the number of correct answers will be calculated. The validity of this test is confirmed with the sign test (Digit Symbol-Coding subtest), which is a sub-test item of the above-mentioned Wexler Adult Intelligence Test 3rd edition.

  In order to perform such an information processing capability test, the cognitive function testing unit 32 first displays a test content explanation screen as shown in FIG. 6 on the touch panel 3031. Subsequently, the cognitive function testing unit 32 displays a practice screen as shown in FIG. 7 on the touch panel 3031. Thereafter, the cognitive function test means 32 starts an actual test. Over the 90-second time limit from this start, the cognitive function testing means 32 sequentially changes the display of the symbols displayed in the area M43, and each time it accepts the selection result of the number from the number list M44 by the subject, Judge whether or not. When the time limit has elapsed, the cognitive function testing unit 32 calculates the number of correct answers and stores it in the memory device 306.

  In step S208, the information suppression function is inspected. Here, an inspection called a flanker test is performed. Specifically, it is a problem of quickly and accurately determining the direction of the center arrow among the five arrows displayed on the touch panel. There are congruent conditions in which all five arrows are pointing in the same direction, and incongruent conditions that are not. An example of the matching condition is “←←←←←”, and an example of the mismatching condition is “→→ ← →→”. This examination consists of a total of 36 trials, each with 18 trials. Among all 36 trials, the match condition and the mismatch condition appear in random order. That is, the order of the first trial is the matching condition, the second trial to the fourth trial are the mismatch condition, the fifth trial and the sixth trial are the mismatch condition again, and so on. Then, the number of correct answers and the correct answer rate for all 36 trials and each condition are calculated. Thus, the information suppression function at the time of performing a task can be inspected by quickly and accurately determining the direction of the center arrow among the five arrows.

  In order to perform such a suppression function test, the cognitive function test unit 32 displays the matching condition and the mismatch condition on the touch panel 3031 in a random order, and accepts the selection result of the arrow direction by the subject each time. Then, the number of correct answers and correct answer rates for all 36 trials, and the number of correct answers and correct answer rates for the matching condition and the non-matching condition are calculated and stored in the memory device 306.

  In step S209, the word delayed reproduction ability is checked. Specifically, it is a test in which the subject voluntarily answers the 10 words learned in step S203. In order to reduce the impact on others in large-scale surveys such as community health services, adopt a response method that writes on paper rather than verbally. However, if the writing ability is remarkably reduced for the reason of mind and body function, an oral answer may be used. The time limit is 60 seconds. As in step S203, the highest score is 10 points and the lowest score is 0 points. By this examination, it is possible to examine the degree of forgetting or memory retention of words once memorized by the subject.

  In this step, in order to check the delayed reproduction ability of such a word, an examiner who is the subject of the examination scores the test subject's answer, and inputs the score result to the testing terminal 3. This input is accepted by the cognitive function testing means 32.

  In step S210, the logical delay recognition capability is checked. Specifically, the subject is asked again to answer the same question as the 10 questions presented in step S201, and the degree to which the content of the story is stored is examined. As in step S201, the highest score is 10 points and the lowest score is 0 points. This test has been validated with the delayed reproduction test (Logical Memory-II) of the revised Wexler memory test described above.

  In this step, the cognitive function checking means 32 displays 10 questions on the touch panel 3031 as in step S201 in order to check such a logical delayed recognition ability. The answer input by the subject is received and scored by the cognitive function testing means 32, and the scored result is stored in the memory device 306.

  In step S301, a data storage screen as shown in FIG. When the subject presses the confirmation button M61, the basic information acquisition unit 31 stores the basic information data stored in the memory device 306 in step S101 in the auxiliary storage device 305. Further, the basic information acquisition unit 31 stores the examination data such as the score, the number of correct answers, the correct answer rate, and the required time, which are stored in the memory device 306 in each of steps S201 to S210, in the auxiliary storage device 305. Then, a data saving completion message M62 and a confirmation button M63 are displayed. When the subject presses the confirmation button M63, the data transmitting / receiving means 33 transmits the basic information data and the examination data stored in the auxiliary storage device 305 to the diagnosis server 2.

  In step S <b> 302, the data transmitting / receiving unit 33 receives a diagnosis result indicating whether the subject has MCI from the diagnosis server 2 and displays it on the touch panel 3031. This diagnosis result can be displayed in HTML format as an example, and the result including numerical values can be presented to the subject and the examiner.

[3. Processing performed by the diagnostic server]
The data transmission / reception means 21 in the diagnosis server 2 receives the basic information data and test data of the subject transmitted from the test terminal 3 in step S301 and stores them in the database 5. The storage format is arbitrary, but can be stored in a CSV file as an example. Then, the diagnosis unit 22 refers to the database 5 and diagnoses whether the subject has MCI according to the age of the subject. Specifically, the diagnostic means 22 diagnoses that the subject is suspected of having MCI when at least one of the ten types of tests from the above-described steps S201 to S210 satisfies the following formula; Diagnose that there is no suspicion of MCI.
(Test data value of subject) <(Average value of test data value in age group according to subject's age) − (Standard deviation of test data value in age group according to age of subject) × 1.5

  Diagnosis can be made by applying inspection data of any one or more of the ten types of inspections to the above equation. In this case, inspection data that does not apply to the above equation is only stored in the database 5. As an example to the last, diagnosis is performed by applying the six types of inspection data of steps S202, S204, S205, S206, S209, and S210 to the above formula, and the four types of inspections of steps S201, S203, S207, and S208 are performed. The inspection data can be stored in the database 5 without being applied to the above formula.

  As described above, all of the test data of the 10 types of examinations of the subject are not always used for diagnosis of the subject, but all 10 types of test data themselves are stored in the database 5. Of the 10 types of inspection data stored in this manner, any one or more types of inspection data can be used for the calculation of the right side of the above formula in the future.

  The diagnosis result as described above is transmitted to the inspection terminal 3 by the data transmission / reception means 21 and received by the inspection terminal 3 in step S302 as described above.

[4. Example]
Next, the reliability and validity of the inspection result obtained by the above embodiment will be described. This is because when a new inspection method is put to practical use, a reasonable evaluation is ensured and high reliability is required.

  First, an examination based on the above embodiment is performed at intervals of one month for 20 elderly people 65 years or older living in a certain region (11 men, 9 women, average age 71.5 years). Performed twice. As a result, the reproducibility of all cognitive function tests was 0.76 to 0.94 (p value <0.01) in terms of intraclass correlation coefficient. Thereby, it has confirmed that the inspection method based on the said embodiment was a very reliable thing.

  Furthermore, in order to confirm the validity of the examination method based on the above-mentioned embodiment for 20 similar elderly people, it is immediately included in a revised version of the Wexler memory examination widely used internationally as a neuropsychological examination. We examined the correlation between the replay test and delayed replay test, the Wexler adult intelligence test version 3 building block test and sign test, the Alzheimer's disease evaluation word recognition task, and the trail making test part A and part B. As a result, a statistically significant correlation with a correlation coefficient of 0.50 to 0.84 (p value <0.05) was recognized. Thereby, the validity of the inspection method based on the said embodiment has been confirmed.

[5. effect]
According to the above-described embodiment, the subject's cognitive function is comprehensively examined from various aspects using 10 types of examinations, and the presence or absence of MCI is objectively determined based on the age of the subject and past measured data in the database. Can be diagnosed automatically. As a result of diagnosis, if there is a suspicion of MCI, prevent future dementia by actively encouraging the subject to participate in a dementia prevention program aimed at preventing care in community health activities be able to.

[6. Others]
In the said embodiment, it is supposed that 10 types of test | inspection from step S201 to S210 will be performed in step S200. However, in another embodiment, at least a part of the obtained inspection data is stored in the database 5 while performing any one or more types of inspections instead of all 10 types and storing all the obtained inspection data in the database 5. Can be used for diagnosis. For example, the inspection data can be used for diagnosis while performing only one type of inspection among the ten types and storing the inspection data in the database 5. Alternatively, any two of the ten types can be tested, and the two types of test data can be stored in the database 5 while one of the two types of test data can be used for diagnosis. Of course, both types of examination data may be used for diagnosis. By doing in this way, the amount of processing of Step S200 can be reduced, maintaining a certain level that can cover a cognitive function as a candidate for examination. However, only step S209 cannot be performed. This is because step S209 is premised on the execution of step S203. Similarly, only step S210 cannot be performed. This is because step S210 is premised on the execution of step S201.

  The basic information acquisition means 31 may be configured to acquire only the date of birth of the subject, or may be configured to accept the input by inputting the age of the subject. In any case, the basic information acquisition means 31 can also be called age data acquisition means.

  In the said embodiment, although the touchscreen type | mold terminal 3 for an inspection was used, it is not restricted to this. A portable terminal that is not a touch panel type or a stationary terminal such as a desktop personal computer can also be used as an inspection terminal. In addition, the operation of the inspection terminal 3 is not limited to the subject himself, and the examiner may operate the test terminal in an auxiliary manner.

  In the above embodiment, the method of performing the inspection by operating the touch panel 3031 is shown, but the present invention is not limited to this. The inspection can also be performed by other input methods such as voice input using the microphone 307, input by operating a keyboard (not shown), input via network communication, and barcode input.

  Moreover, in the said embodiment, although the program for a cognitive function test | inspection presupposed that it was installed in the terminal 3 for a test | inspection, it is not restricted to this. For example, the diagnosis server 2 may execute the program installed in itself, and the inspection terminal 3 may access the diagnosis server 2 to perform the processing as illustrated in FIG.

  5 to 8 illustrate the basic information input screen, the inspection content explanation screen, the practice screen, and the data storage screen, respectively, but the layout of each screen can be arbitrarily changed.

  Also, the inspection content teaching method, the inspection task presentation method, and the score format can be arbitrarily changed.

  Although the HTML format and the CSV format are exemplified as the file format, other file formats may be used.

  The functional configuration and physical configuration of each of the diagnostic server 2, the testing terminal 3, and the database 5 described above are not limited to the above-described modes, and for example, the functions and physical resources may be integrated and implemented. On the other hand, it is possible to implement further distributed. For example, the data transmitting / receiving unit 21 may be divided into a data transmitting unit and a data receiving unit. The same applies to the data transmission / reception means 33. Further, the diagnostic system 1 may be configured by connecting the basic information acquisition unit 31, the cognitive function test unit 32, and the diagnosis unit 22 so as to communicate with each other without providing the data transmission / reception units 21 and 33.

DESCRIPTION OF SYMBOLS 1 Diagnosis system 2 Diagnostic server 3 Inspection terminal 4 Network 5 Database 21 Data transmission / reception means 22 Diagnosis means 31 Basic information acquisition means 32 Cognitive function inspection means 33 Data transmission / reception means 301 CPU
302 Interface device 303 Input and display device 305 Auxiliary storage device 306 Memory device 307 Microphone 308 Speaker 310 Bus 3031 Touch panel

Claims (6)

A first test that is a test of logical immediate memory ability, a second test that is a test of visuospatial cognitive ability, a third test that is a test of immediate memory ability of words, orientation, memory, and computing power A fourth test that is a test of cognitive function including verbal ability and graphic ability, a fifth test that is a test of attention function, a sixth test that is a test of performance function, and a test of information processing ability. For each test of the seventh test, the eighth test that is a test of suppression function, the ninth test that is a test of delayed reproduction ability of words, and the tenth test that is a test of logical delayed recognition ability, Cognitive function testing means for obtaining test data;
Age data acquisition means for acquiring age data of the subject;
The test data acquired by the cognitive function test means and the test data of at least one of the first test to the tenth test of the subject are in an age group corresponding to the age data acquired by the age data acquisition means A diagnostic means for diagnosing whether or not the subject has mild cognitive dysfunction in comparison with test data obtained by performing the at least one test on a plurality of persons, Presence or absence diagnostic system.   The diagnosis means makes a diagnosis based on the test data of the at least one test of the subject and an average value and standard deviation of test data obtained by performing the at least one test on the plurality of persons. The diagnostic system according to claim 1, wherein A first test that is a test of logical immediate memory ability, a second test that is a test of visuospatial cognitive ability, a third test that is a test of immediate memory ability of words, orientation, memory, and computing power A fourth test that is a test of cognitive function including verbal ability and graphic ability, a fifth test that is a test of attention function, a sixth test that is a test of performance function, and a test of information processing ability. For each test of the seventh test, the eighth test that is a test of suppression function, the ninth test that is a test of delayed reproduction ability of words, and the tenth test that is a test of logical delayed recognition ability, Cognitive function testing means for obtaining test data;
Age data acquisition means for acquiring age data of the subject;
The test data acquired by the cognitive function test means and the test data of at least one of the first test to the tenth test of the subject are in an age group corresponding to the age data acquired by the age data acquisition means To the diagnostic server for diagnosing whether or not the subject has mild cognitive dysfunction against the test data obtained by performing the at least one test on a plurality of persons, Data transmitting means for transmitting inspection data of at least one of the tenth inspection and the age data from the first inspection;
A cognitive function testing terminal comprising: a data receiving unit that receives a diagnosis result from the diagnostic server.   The diagnosis server performs diagnosis based on the test data of the at least one test of the subject and the average value and standard deviation of test data obtained by performing the at least one test on the plurality of persons. The cognitive function testing terminal according to claim 3, which is a device. A first test that is a test of logical immediate memory ability, a second test that is a test of visuospatial cognitive ability, a third test that is a test of immediate memory ability of words, orientation, memory, and computing power A fourth test that is a test of cognitive function including verbal ability and graphic ability, a fifth test that is a test of attention function, a sixth test that is a test of performance function, and a test of information processing ability. For each test of the seventh test, the eighth test that is a test of suppression function, the ninth test that is a test of delayed reproduction ability of words, and the tenth test that is a test of logical delayed recognition ability, Cognitive function test processing to obtain test data;
Age data acquisition processing for acquiring age data of the subject;
The test data acquired by the cognitive function test process and the test data of at least one of the first test to the tenth test of the subject is an age corresponding to the age data acquired by the age data acquisition process. To a diagnostic server for diagnosing whether or not the subject has mild cognitive dysfunction against the test data obtained by performing the at least one test on a plurality of persons in a layer, A data transmission process for transmitting inspection data of at least one of the first inspection to the tenth inspection and the age data;
A cognitive function test program for causing a cognitive function test terminal to execute a data reception process for receiving a diagnosis result from the diagnostic server.   The diagnosis server performs diagnosis based on the test data of the at least one test of the subject and the average value and standard deviation of test data obtained by performing the at least one test on the plurality of persons. The program for a cognitive function test | inspection of Claim 5 which is a thing.

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