JP2017122907A - Method for producing silicone hydrogel used in ophthalmology - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a method for producing silicone hydrogel used in ophthalmology.SOLUTION: A method for producing silicone hydrogel used in ophthalmology includes: a step (S1) of subjecting a component that does not contain at least one kind of silicon to a first polymerization reaction to form a polymer containing no silicon; a step (S2) of mixing the polymer containing no silicon with the component containing at least one kind of silicon to form a composition; and a step (S3) of subjecting the composition to a second polymerization reaction to solidify the composition.SELECTED DRAWING: Figure 1

Description

  The present invention relates to a method for producing a silicone hydrogel used in ophthalmology, and particularly improves the problem of increased production cost due to reaching superior oxygen permeability, water content and low oil adhesion in the prior art. The present invention relates to a method for producing a silicone hydrogel.

  The development history of contact lenses has been nearly 100 years old, and is one of the important medical equipment universally used by ordinary eyeglasses. Leonardo da Vinci (Tatsumonishi) first submitted an idea to apply the lens directly to the eyeball in 1508, and German scientist Adolf Eugen Fick successfully manufactured the first glass contact lens in 1887. Because of its low oxygen permeability, it easily induces eye diseases such as keratitis. Focusing on such characteristics as safety, light permeability, oxygen permeability, and wearing comfort, contact lenses have been constantly improved, and new materials and manufacturing methods have been developed.

  Since the 1950s, Czech scientists made hydrogels using polyhydroxyethyl methacrylate (HEMA) material and invented soft contact lenses, this material is still used. With the advancement of science and technology, the direction of advancement of contact lens materials also develops towards high oxygen permeability and high comfort.

  In general, contact lenses require attention to characteristics such as safety, light transmission, oxygen transmission, and wearing comfort. Since the material of the conventional HEMA hydrogel is hydrophilic, it has excellent wearing comfort, but its oxygen permeability is low. Therefore, when it is worn for a long time, the problem of corneal edema and blood vessel growth tends to appear. In order to increase the oxygen permeability of HEMA hydrogels, measures are generally taken to reduce the lens thickness or increase the water content of the lens, but there are also limitations to the improvement effect of these two methods, and the lens machine With the disadvantage of losing its natural properties. In recent years, a lot of research has sought to develop contact lenses containing polysilicon oxide materials, and due to the high oxygen permeability of the silicon material itself, oxygen molecules can penetrate the lens smoothly and arrive at the cornea. As a result, not only the oxygen permeability of the contact lens can be increased, but also the wearing comfort is further improved. At present, the most common silicon material is polysiloxane (polysiloxane or silicon), and the polysiloxane material itself is relatively hydrophobic and has poor wettability. In addition, the surface of the contact lens is easily oiled, which is the direction in which the polysiloxane hydrogel contact lens must be actively improved.

  An example of a method for increasing the wettability of a conventional polysiloxane hydrogel will be described. (1) A hydrophilic post-processing treatment is performed on the already molded lens. For example, U.S. Pat. No. 4,241,014 discloses using plasma to treat the surface of a polysiloxane hydrogel lens, and U.S. Pat. No. 6,099,852 already molds a silane coupling agent. Coating the surface of the prepared polysiloxane hydrogel lens, then immersing it in a hydrophilic substance and grafting the hydrophilic substance on the lens surface by chemical bonding to increase the wettability of the lens surface Posted. Such a post-processing method can increase the wetness, but since the processing process is complicated, the efficiency is insufficient in the manufacturing process, and the manufacturing cost is high. (2) In U.S. Pat. No. 8,870,3891, a silicone hydrogel lens is very wet by adding a specific long-time solidification step to a specific component, but this technique consumes a long time in the solidification process and The effect of improving hydrophilicity and oil adhesion is also finite.

  On the premise that oxygen permeability, moisture content and oil adhesion problems are not affected, it is still an issue to be solved in the industry to improve the above-mentioned problems such as manufacturing cost and efficiency.

  A method for producing a silicone hydrogel used in ophthalmology according to the present invention includes a step (S1) of performing a first polymerization reaction on at least one kind of silicon-free component to form a silicon-free polymer, and a silicon-free polymer. And a step of forming a composition by mixing at least one silicon-containing component (S2), and a step of performing a second polymerization reaction on the composition and solidifying the composition (S3).

  In a preferred embodiment of the present invention, the first polymerization reaction is performed under an environment of 40 ° C to 100 ° C.

  In a preferred embodiment of the present invention, the first polymerization reaction is performed in an environment of 50 ° C to 90 ° C.

  In a preferred embodiment of the present invention, the first polymerization reaction is performed under an environment of 55 ° C to 80 ° C.

  In a preferred embodiment of the present invention, the reaction time of the first polymerization reaction is 10 minutes to 72 hours.

  In a preferred embodiment of the present invention, the reaction time of the first polymerization reaction is 25 minutes to 24 hours.

  In a preferred embodiment of the present invention, the reaction time of the first polymerization reaction is 40 minutes to 12 hours.

  In a preferred embodiment of the present invention, the reaction time for the second polymerization reaction and solidification is 20 minutes to 2 hours.

  In a preferred embodiment of the present invention, the reaction time for the second polymerization reaction and solidification is 25 minutes to 35 minutes.

  In a preferred embodiment of the present invention, the reaction time for the second polymerization reaction and solidification is within 30 minutes.

  In a preferred embodiment of the present invention, the silicon-free component comprises at least one silicon-free monomer, and the molecular weight of the silicon-free monomer is less than 700.

  In a preferred embodiment of the invention, the silicon-free component comprises at least one silicon-free macromer, and the molecular weight of the silicon-free macromer is greater than 700.

  In a preferred embodiment of the present invention, the weight percentage of the composition occupied by the silicon-containing component is 6-80 wt%.

  In a preferred embodiment of the present invention, the weight percentage of the composition occupied by the silicon-containing component is 14 to 65 wt%.

  In a preferred embodiment of the present invention, the weight percentage of the composition occupied by the silicon-containing component is 21-51 wt%.

  In a preferred embodiment of the present invention, the weight percentage of the composition occupied by the silicon-free component is 15 to 86 wt%.

  In a preferred embodiment of the present invention, the weight percentage of the composition occupied by the silicon-free component is 18-61 wt%.

  In a preferred embodiment of the present invention, the weight percentage of the composition occupied by the silicon-free component is 25-56 wt%.

  In a preferred embodiment of the present invention, the silicon-free component comprises a hydrophilic silicon-free component and a hydrophobic silicon-free component, and the weight percentage of the composition occupied by the hydrophilic silicon-free component is the hydrophobic silicon-free component. More than the weight percentage of the composition.

  In a preferred embodiment of the present invention, the step (S2) includes a step (S21) of forming a silicon-containing polymer by performing a third polymerization reaction on at least one silicon-containing component, and a silicon-free polymer and silicon. (S22) which mixes the polymer containing and forms a composition.

  In a preferred embodiment of the present invention, in the above step (S2), another one of the silicon-free component, the silicon-free polymer and at least one silicon-containing component is mixed to form a composition.

  In a preferred embodiment of the present invention, in the step (S1), at least one initiator is added to at least one silicon-free component to perform the first polymerization reaction.

  In a preferred embodiment of the present invention, in the step (S1), at least one crosslinking agent is added to at least one kind of silicon-free component to perform the first polymerization reaction.

  In a preferred embodiment of the present invention, in the above step (S2), the composition is formed by mixing the non-silicon-containing polymer, at least one silicon-containing component and at least one initiator.

  In a preferred embodiment of the present invention, in the above step (S2), a silicon-free polymer, at least one silicon-containing component and at least one crosslinking agent are mixed to form a composition.

  In a preferred embodiment of the present invention, in the step (S3), at least one initiator is added to perform a second polymerization reaction on the composition and solidify.

  In a preferred embodiment of the present invention, in the step (S3), at least one cross-linking agent is added to perform a second polymerization reaction on the composition and solidify.

  In a preferred embodiment of the present invention, in the step (S3), solidification is performed using a light solidification method.

  In a preferred embodiment of the present invention, in the step (S3), solidification is performed using a heat solidification method.

  Compared to the prior art, in the method for producing a silicone hydrogel used in ophthalmology according to the present invention, the silicon-free component and the silicon-containing component are polymerized in each case, and at least two polymerization reactions are used. The lens product has the characteristics of high wetness and low oil adhesion, and can reach the effect of shortening the long solidification processing time and increasing the efficiency and production volume.

It is a flowchart of the manufacturing method of the silicone hydrogel which concerns on this invention. It is a figure which shows the result after the Example and comparative example of this invention were dye | stained by Sudan Black B. It is a figure which shows the result after the Example and comparative example of this invention were dye | stained by Sudan Black B. It is a figure which shows the result after the Example and comparative example of this invention were dye | stained by Sudan Black B. It is a figure which shows the result after the Example of this invention was dye | stained by Sudan Black B. It is a figure which shows the result after the Example of this invention was dye | stained by Sudan Black B.

  The present invention provides a method for producing a silicone hydrogel used in ophthalmology, and can achieve an effect of reducing high wetness, low oil adhesion, and production cost. Hereinafter, objects, features, and advantages of the present invention will be described in detail with reference to the drawings.

  In the description below, a “component” is a unit compound or chemical structure that can be polymerized and can be divided into monomers or macromers according to different average molecular weights, and divided into hydrophobic and hydrophilic according to different chemical properties. Can do. “Monomer” means a low molecular weight compound or chemical structure having an average molecular weight of less than 700, the monomer can form a “polymer” by a polymerization reaction, and “macroma” has an average molecular weight of 700 or more By high molecular weight compound or chemical structure, macromers can form a polymer by a polymerization reaction.

  “Silicon-containing component” means any silicon-containing repeatable compound or chemical structure, and the silicon-containing component comprises “silicon-containing monomer” and “silicon-containing macromer”. “Silicon-free component” means any silicon-free repeatable unit compound or chemical structure, which can be divided into hydrophilic and hydrophobic by different polarities, “silicon-free monomer” and “silicone by different molecular weights. It can be divided into “macromas not included”. However, since silicon generally binds to oxygen and then again bonds to the hydrogel material, in the following description of the invention, “comprising silicon” refers to a chemical structure containing silicon oxygen bonds (—Si—O—). Represents.

  A “silicone-containing monomer” has any at least one —Si—O—, has an average molecular weight of less than 700, and can be polymerized unit compounds or chemical structures (eg, 3 containing at least one non-repeating —Si—O— -Tris (trimethylsiloxy) silyl] propyl methacrylate [(3- [Tris (trimethylsilyl) propyl] propylmethacrylate, TRIS), or polydimethylsiloxane having at least two repeating -Si-O- and having an average molecular weight of less than 700 PDMS)). Other “silicon-containing monomers” include, for example, 2- (trimethylsilyloxy) ethyl methacrylate (2- (trimethylsilyloxy) ethyl methacrylate), (3-methacryloxy-2-hydroxypropoxy) propylbis (trimethylsiloxy) methylsilane ((3- (Methacryloxy-2-hydroxypropoxy) propylbis (trimethylsiloxy) methylsilane, SiGMMMA), (methacryloxymethyl) bis (trimethylsiloxy) methylsilane ((methacryloxymethyl) thylmethyl) Methacryloxymethylphenethyltris (trimethylsiloxy) silane), mono-methacryloxypropyl terminated polydimethylsiloxane (Monomethacryloxypropyl terminated polydimethylsiloxane), it is a methacryloxypropyl terminated polydimethylsiloxane (Methacryloxypropyl terminated polydimethylsiloxane). Other selections can refer to US7901073 and US8420711.

  A “silicone-containing macromer” includes any unit compound or chemical structure having any at least two repeating —Si—O—, an average molecular weight of 700 or more, and a polymerizable (eg, at least two repeating —Si—O—). And a molecular weight greater than 700). Other silicone-containing monomers include, for example, monomethacryloxypropyl terminated polydimethylsiloxane (Monomethacryloxypropyl terminated dimethylsiloxane, mPDMS), methacryloxypropyl terminated polydimethylsiloxane (Methacryloxypropylene terminated 7 such as U.S.A. You can refer to the selection.

  “Silicon-free components” means repeatable unit compounds or chemical structures that do not contain silicon, and can be divided into hydrophobic and hydrophilic depending on their chemical properties. Since the present invention uses only a unit compound that does not contain silicon and has an average molecular weight of less than 700, a related definition will be made hereinafter only for the “monomer not containing silicon” used in the present invention.

  “Silicon-free monomer” means a unit compound or chemical structure having a molecular weight of less than 700 and not containing silicon, and comprises a hydrophilic silicon-free monomer and a hydrophobic silicon-free monomer. Hydrophilic silicon-free monomers include, for example, N-vinyl pyrrolidone (NVP), N-methyl-N-vinylacetamide (N-Methyl-N-vinylacetamide, MVA), N, N-dimethylacrylamide. (N, N-dimethyl acrylamide, DMA), N- (hydroxymethyl) acrylamide (N- (Hydroxymethyl) acrylamide), N-hydroxyethyl acrylamide (N-Hydroxyethyl acrylamide), 2-hydroxyethyl methacrylate (2-Hydroxymethyl ether) HEMA), hydroxypropyl methacrylate (Hydroxypropyl methacrylate) rylate and / or Hydroxypropyl methacrylate, hydroxybutyl methacrylate (HOBMA), poly (ethylene glycol) methacrylate (poly (ethylene glycol), poly (ethylene glycol), poly (ethylene glycol), poly (ethylene glycol) (Glyceryl methacrylate), Glycidyl methacrylate, 2-hydroxyethyl acrylate (HEA), Hydroxypropyl acrylate (Hydr) Xypropyl acrylate and / or Hydroxyisopropyl acrylate), 4- hydroxybutyl acrylate (4-Hydroxybutyl acrylate), glyceryl acrylate (Glyceryl acrylate) and the like. Hydrophobic silicon-free monomers include, for example, lauryl methacrylate, methyl methacrylate (MMA), ethyl methacrylate, propyl methacrylate, and isopropyl methacrylate. Butyl methacrylate, hexyl methacrylate, 2-ethylhexyl methacrylate, stearyl methacrylate, or Octa ethyl methacrylate, Isodecyl methacrylate, Isobornyl methacrylate, Ethyl acrylate, Propyl acrylate, Propyl acrylate, Propyl acrylate (Ipyl acrylate) -Ethylhexyl acrylate (2-Ethylhexyl acrylate), Octadecyl acrylate (Stearyl acrylate or Octadecyl acrylate), Isodecyl acrylate (Isodecyl acrylate), Lauryl acrylate ( auryl acrylate), and the like.

  In the following description of the present invention, “composition” means an unfinished hydrogel containing silicon after the initial polymerization reaction (or at least one polymerization reaction) and before the solidification step.

  In the following description of the present invention, for “room temperature”, the temperature range is 20 ° C. to 30 ° C., and the temperature range is 23 ° C. to 27 ° C.

  As shown in FIG. 1, in the method for producing a silicone hydrogel used in ophthalmology according to the present invention, a step of forming a polymer containing no silicon by performing a first polymerization reaction on at least one kind of silicon-free component ( S1), a step of mixing a non-silicon-containing polymer and at least one silicon-containing component to form a composition (S2), a second polymerization reaction on the composition and solidifying (S3); Is provided.

  The weight percentage of the composition occupied by the silicon-containing component is 6 to 80 wt%, preferably 14 to 65 wt%, and more preferably 21 to 51 wt%. The silicon-containing component comprises a silicon-containing monomer and a silicon-containing macromer. For example, in embodiments of the present invention, silicon-containing monomer SiGMMA is used and accounts for 5 to 75 wt% of the composition, and in preferred embodiments, SiGMMA accounts for 10 to 60 wt% of the composition, and in more preferred embodiments, SiGMMA accounts for 15 to 45 wt% of the composition. Also, for example, in an embodiment of the present invention, silicon-containing macromer mPDMS is used and occupies 1 to 45 wt% of the composition. In a preferred embodiment, mPDMS occupies 4 to 25 wt% of the composition. MPDMS accounts for 6-15 wt% of the composition.

  The weight percentage of the composition occupied by the silicon-free component is 15-86 wt%, preferably 18-61 wt%, more preferably 25-56 wt%, the weight of the composition occupied by the monomer not containing hydrophilic silicon The percentage is greater than the weight percentage of the composition occupied by the monomer free of hydrophobic silicon.

  In an embodiment of the present invention, the hydrophilic silicon-free monomer accounts for 5 to 85 wt% of the composition, in a preferred embodiment, 10 to 60 wt% of the composition, and in a more preferred embodiment, 20 to 20 wt% of the composition. Occupies 55 wt%. Non-hydrophilic silicon-containing monomers preferably used include, but are not limited to, NVP, MVA, DMA, N, N-Diethylacrylamide, N- (Hydroxymethyl) acrylamide, and N-Hydroxyethyl amide.

  Hydrophobic silicon-free monomers among silicon-free components are mainly used to adjust the mechanical properties of contact lenses. In an embodiment of the present invention, the hydrophobic silicon-free monomer accounts for 0.1-10 wt% of the composition, and in a preferred embodiment, the hydrophobic silicon-free monomer accounts for 0.5-7.5 wt% of the composition. In a more preferred embodiment, the hydrophobic silicon free monomer accounts for 1-5 wt% of the composition. Non-hydrophobic silicon-containing monomers that are preferably used include, but are not limited to, lauryl methacrylate and MMA.

  A crosslinking agent is used to allow the monomer to smoothly perform the polymerization reaction, and the polymer polymer has a crosslinking density required by the polymer formed so that the two polymer chains react to form a network polymer. To join. Any polymerization reaction can be selected and added with a suitable cross-linking agent, so that a cross-linking agent can be selectively added when one polymerization reaction begins, for example, in step (S1) or In the preferred embodiment, at least one crosslinking agent is added in step (S1) and then step (S2) is performed, so that the resulting solidified product is relatively stable. It is also possible to selectively add at least one cross-linking agent in other application times, for example in step (S2). In an embodiment of the present invention, the crosslinking agent accounts for 0.1 to 3 wt% of the composition, and in a preferred embodiment, the crosslinking agent accounts for 0.3 to 2 wt% of the composition, and in a more preferred embodiment, The crosslinking agent accounts for 0.5 to 1.5 wt% of the composition. In an embodiment of the present invention, preferably used crosslinking agents include but are not limited to isocyanate ethyl methacrylate (2-isocyanatoethyl methacrylate, IEM) and ethylene glycol dimethacrylate (EGDMA). Other selectable cross-linking agents are diethylene glycol dimethacrylate (Di (ethyleneglycol) dimethylacrylate), triethyleneglycol dimethacrylate (Teethyleneglycol dimethacrylate), tetraethylene glycol dimethacrylate (Tetraethylene glycol dimethacrylate glycol dimethacrylate). diacrylate, diethylene glycol diacrylate (Di (ethylene glycol) diacrylate), triethylene glycol diacrylate (Triethylene glycol diacrylate), tetraethylene glycol diacrylate N-N'-Methylenebisacrylamide (N, N'-Methylenebis (acrylamide)), N, N'-Ethylenebisacrylamide (N, N'-Ethylenbis (acrylamide)), N, N '-(1,2-dihydroxyethylene) bisacrylamide (N, N'-(1,2-Dihydroxyethylene) bisacrylamide), trimethylolpropane trimethacrylate, N, N'-hexamethylenebis-methacrylamide (N, N'-hexamethylenebis-methacrylamide) N, N′-Hexamethylenebis (methacrylamide)), Roll trimethacrylate (Glycerol trimethacrylate), Polyethylene glycol dimethacrylate (Polyethylene glycol diacrylate), Polyethylene glycol diacrylate (Polyethylene glycol triacrylate), Vinyl methacrylate (Vinyl methylacrylate) Glycidyl acrylate, 3-chloro-2-hydroxypropyl methacrylate, mono 2- (methacryloyloxy) ethyl maleate (mono-2- (methacryloyloxy) ethyl maleate), diurethane dimethacrylate (3-urepropenyl-α, α-dimethylbenzyl isocyanate (3-Isopropenyl-α, α) -Dimethylbenzoyl isocynate), etc., which can be selected and used according to different reactants and demands.

  Initiators can be divided into thermal initiators and photoinitiators according to different evoked reaction modes. The initiator is used to induce polymerization cross-linking of the component and has a deterministic effect on the solidified composition, and has excellent dimensional stability when the composition is molded, so any one polymerization An initiator can be selectively added when the reaction begins, for example it can be added at step (S1) or / and at step (S2). The thermal initiator used in the examples of the present invention is azobisisobutyronitrile (AIBN), and in other examples, 4,4′-azobis (4-cyanovaleric acid) (4,4′- Azobis (4-cyanovaleric acid)), 1,1′-azobis (cyclohexanecarbonitrile) (1,1′-Azobis (cyclohexanecarbononitrile)), 2,2′-azobis (2-methylpropionamidine) (2,2 ′ -Azobis (2-methylpropionamide)), 2,2'-azobis (2-methylpropionamidine) dihydrochloride (2,2'-Azobis (2-methylpropionamide) dihydro) hloride), 2,2′-azobis [2- (2-imidazolin-2-yl) propane] dihydrochloride (2,2′-Azobis [2- (2-imidazolin-2-yl) propane] dihydrochloride), 2 , 2′-azobis {2- [1- (2-hydroxyethyl) -2-imidazolin-2-yl] propane} dihydrochloride (2,2′-Azobis {2- [1- (2-hydroxyethyl) -2 -Imidazolin-2-yl] propane} dihydrochloride), 2,2′-azobis (1-imino-1-pyrrolidino-2-ethylpropane) dihydrochloride (2,2′-Azobis (1-imino-1-pyrrolidino-) 2-ethylprop ne) dihydrochloride), 2,2′-azobis {2-methyl-N- [1,1bis (hydroxymethyl) -2-hydroxyethyl] propionamide} (2,2′-Azobis {2-methyl-N— [1,1-bis (hydroxymethyl) -2-hydroxyethyl] propionamide}), 2,2′-azobis [2-methyl-N- (2-hydroxyethyl) propionamide] (2,2′-Azobis [2- methyl-N- (2-hydroxyethyl) propionamide]), 2,2′-azobis (4-methoxy-2,4-dimethylvaleronitrile (2,2′-Azobis (4-methoxy-2,4-dimethyl valeronitrile)) ), Peracid Use, such as benzoyl (Benzoyl peroxide). The photoinitiators used in the examples of the present invention are Irgacure® 1173 (2-Hydroxy-2-methylpropiophenone) and phenylbis (2,4,6-trimethylbenzoyl) phosphine oxide (phenylbis (2,4,4)). 6-trimethylbenzoyl) phosphine oxide, BAPOs), and in other examples, diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide (Diphenyl (2,4,6-trimethylbenzoyl) phosphine oxide), 2,2- Dimethoxy-2-phenylacetophenone (2,2-Dimethoxy-2-phenylacetophenone) or the like is used.

  In the examples of the present invention, the initiator accounts for 0.01-4 wt% of the composition, and in the preferred embodiment, the initiator accounts for 0.1-1.8 wt% of the composition, and in a more preferred embodiment. The initiator accounts for 0.3-1.2 wt% of the composition.

  The terminator is used to terminate the polymerization reaction, and the terminator can be selectively added when any one polymerization reaction is to be terminated. For example, the terminator can be added in step (S1). A terminator can be added at the time point to be terminated. The terminator used in the examples of the present invention is monomethyl ether hydroquinone (MEHQ), and another selectable terminator is 2-ethoxyphenol.

  In the examples of the present invention, the terminator accounts for 0.01-0.5 wt% of the composition, and in the preferred example, the terminator accounts for 0.025-0.3 wt% of the composition, more preferred examples. , The terminator accounts for 0.05 to 0.1 wt% of the composition.

  In the above-described method of the present invention, the first polymerization reaction in step (S1) is performed under an environment of 40 ° C. to 100 ° C., and the reaction time is 10 minutes to 72 hours; in a preferred embodiment of the present invention The ambient temperature range is 50 ° C. to 90 ° C., and in a further preferred embodiment of the present invention, the ambient temperature range is 55 ° C. to 80 ° C .; in the preferred embodiment of the present invention, the reaction time is 25 minutes to 24 hours, and in a further preferred embodiment of the invention the reaction time is 40 minutes to 12 hours.

  In the above-described method of the present invention, other silicon-free components can be selectively added and mixed together in step (S2), and in another embodiment of the present invention, silicon is included in step (S2). The component can be selectively polymerized first and then mixed with a polymer containing no silicon to perform the second polymerization reaction and solidification in step (S3).

  In the above-described method of the present invention, the second polymerization reaction and the solidification in step (S3) are performed at the same time, and the solidification method can be thermal solidification or photosolidification with different solidifying agents, and the reaction time is 20 minutes to 2 hours. It is. In a preferred embodiment of the present invention, the time required for the second polymerization reaction and solidification in step (S3) can be controlled from 25 minutes to 35 minutes. In a more preferred embodiment of the present invention, step (S3) The time required for the second polymerization reaction and solidification can be controlled within 30 minutes. After the solidification step, cleaning and disinfection are generally performed to ensure surface cleanliness, for example, cleaning with a suitable solvent or pure water and using PBS at a temperature of 120 ° C. for about 30 minutes. disinfect.

  Hereinafter, the present invention will be described more specifically by describing in detail different embodiments of the present invention, but the present invention is not limited to the following embodiments.

  The detailed components and steps of the first embodiment of the present invention will be described below.

  Step (S1): 7.71 grams (g) of HOBMA, 43.63 grams of NVP and 0.14 grams of AIBN in a 250 milliliter (mL) beaker and stirred for 1 hour Completely dissolve to form reactant 1A. 13.37 grams of NVP and 4.45 grams of MEHQ are added to a 50 mL beaker and stirred for 1 hour to completely dissolve MEHQ and form reactant 1B. Heat 51.48 grams of reactant 1A to an equilibri state in a 64 ° C. oil bath. When reactant 1A is heated to 71.0 ° C., 3.2 grams of reactant 1B is added to form reactant 1C. Reactant 1C is transferred to a 25 ° C. water bath and the temperature is lowered below 40 ° C. to form sticky reactant 1C. Reactant 1C was removed from the 25 ° C. water bath and stirred for 3 hours in a 25 ° C. environment, then added to Reactant 1C with 2.18 grams of IEM sticking to the 25 ° C. environment. A silicon-free polymer is formed by subsequent stirring for 11 hours.

  Step (S2): 1.1752 grams of silicon-free polymer, 0.5122 grams of SiGMMA, 0.0283 grams of EGDMA and 0.0225 grams of Irgacure 1173 in a dark environment (an environment avoiding light) By mixing and stirring, the composition is formed.

Step (S3): After leaving about 50 μL of the composition in a clean polypropyne female mold, pressure is applied over the corresponding male mold to form a contact lens-shaped composition. In this example, the composition solidifies with the second polymerization reaction and solidifies by irradiation with ultraviolet rays (intensity is 4 mW / cm ² ) for 30 minutes. After 30 minutes of polymerization and solidification, the female mold and male mold are separated, and the composition after solidification is a contact lens, attached to the female mold or male mold, and soaked with 50% IPA. Drop off the mold. Thereafter, it is washed 3 times with 50% IPA, each time for 20 minutes, then immersed in 25% IPA for 20 minutes, then washed 3 times with pure water, each time for 20 minutes. After the cleaning step, the contact lens is dipped and mounted in a phosphate buffer.

  In the above-mentioned first embodiment of the present invention, first, using AIBN as a thermal initiator, a monomer HOBMA that does not contain hydrophilic silicon and a monomer NVP that does not contain hydrophilic silicon (a reactant 1A is formed) are induced. Then, the monomer NVP not containing hydrophilic silicon, the terminator MEHQ (forming the reactant 1B), and the cross-linking agent IEM are sequentially added to form a silicon-free polymer. Next, the polymer without polymer containing silicon and the monomer SiGMMA containing silicon are polymerized first, and using the crosslinking agent EGDMA and the photoinitiator Irgacure 1173, the polymerization reaction and solidification of the polymer without silicon and the monomer SiGMMA containing silicon (step) (Second polymerization reaction and solidification in (S3)) are induced to form a solidified composition. Finally, the contact lens is formed by washing.

  The detailed components and steps of the second embodiment of the present invention will be described below.

  Step (S1): Add 50.00 grams of NVP and 0.21 grams of AIBN to a 150 mL beaker and stir in 1 hour to completely dissolve AIBN. Reactant 2A is formed by adding 15 grams of NVP-AIBN mixture and 0.25 grams of IEM into a 50 mL beaker and stirring for 30 minutes. Add 40.00 grams of NVP and 0.45 grams of MEHQ into a 150 mL beaker and stir for 1 hour to completely dissolve MEHQ and form reactant 2B. Add 50.04 grams of NVP to a 250 mL beaker and then heat to equilibri state in a 59.0 ° C oil bath. When 50.04 grams of NVP is heated to an equilibrium state of 58 ° C., Reactant 2C is formed by polymerizing 13.6 mL of Reactant 2A in hot NVP. When the reaction temperature reaches 68.6 ° C., the reactant 2C is transferred to a 25 ° C. water bath and the temperature is lowered to form a sticky reactant 2C. When the sticky reactant 2C reaches 46.0 ° C., 6.77 mL of reactant 2B is added to the sticky reactant 2C and stirred for 30 minutes under an environment of 25 ° C. Then, 15.05 grams of HEMA is added and subsequently stirred for 12 hours to form a silicon free polymer.

  Step (S2): 4.7205 grams of silicon-free polymer, 4.0023 grams of SiGMMA, 0.0543 grams of EGDMA and 0.0769 grams of AIBN are mixed and the above mixture is stirred in a dark environment for 1 hour. By doing so, a composition is formed.

  Step (S3): After leaving about 50 μL of the composition in a clean polypropyne female mold, pressure is applied over the corresponding male mold to form a contact lens-shaped composition. In this example, the composition solidifies with the second polymerization reaction and heat solidifies in an environment of 120 ° C. for 30 minutes. After 30 minutes of polymerization and solidification, the female mold and male mold are separated, and the composition after solidification is a contact lens, attached to the female mold or male mold, and soaked with 50% IPA. Drop off the mold. Thereafter, it is washed 3 times with 50% IPA, each time for 20 minutes, then immersed in 25% IPA for 20 minutes, then washed 3 times with pure water, each time for 20 minutes. After the cleaning step, the contact lens is dipped and mounted in a phosphate buffer.

  In the above-mentioned second embodiment of the present invention, first, a silicone-free monomer is induced by using the thermal initiator AIBN to induce a copolymerization reaction (forming reactant 2A) of the monomer-free silicone NVP and the crosslinking agent IEM. NVP, terminator MEHQ (forming reactant 2B) and hydrophilic silicon-free monomer HEMA are sequentially added to form a silicon-free polymer. Next, the polymer containing no polymer containing silicon and the monomer SiGMMA containing silicon are polymerized first, and the polymerization reaction of the polymer containing no silicon and the monomer SiGMMA containing silicon using the crosslinking agent EGDMA and the thermal initiator AIBN (step (S3)). The second polymerization reaction and solidification) to form a lens-shaped solidified composition. Finally, the contact lens is formed by washing.

  Hereinafter, detailed components and steps of the third embodiment of the present invention will be described.

  Step (S1): Add 50.00 grams of NVP and 0.21 grams of AIBN to a 150 mL beaker and stir in 1 hour to completely dissolve AIBN. Reactant 3A is formed by adding 15 grams of NVP-AIBN mixture and 0.25 grams of IEM into a 50 mL beaker and stirring for 30 minutes. MEHQ is completely dissolved to form reactant 3B by adding 40.00 grams of NVP and 1.69 grams of MEHQ into a 150 mL beaker and stirring for 1 hour. 50.01 grams of NVP is added to a 250 mL beaker and then heated to an equilibrium state in an oil bath at 61.0 ° C. When NVP is heated to equilibrium at 59 ° C., 13.6 mL of reactant 3A is added to hot NVP to polymerize to form reactant 3C. When the reaction temperature reaches 68.8 ° C., the reactant 3C is transferred to a 25 ° C. water bath and the temperature is lowered to form a sticky reactant 3C when the reactant 3C reaches 54.5 ° C. . 6. Add 677 mL of reactant 3B to sticky reactant 3C and stir for 30 minutes under 25 ° C. environment, then add 15.05 grams of HEMA for 12 hours By stirring, a polymer free of silicon is formed.

  Step (S2): Mix 3.5919 grams of silicon-free polymer, 4.2313 grams of SiGMMA, 0.0435 grams of EGDMA, 0.0664 grams of Irgacure 1173 and 0.0318 grams of BAPOs, and the above mixture Is stirred in a dark environment for 1 hour to form a composition.

Step (S3): After leaving about 50 μL of the composition in a clean polypropyne female mold, pressure is applied over the corresponding male mold to form a contact lens-shaped composition. In this example, the composition solidifies with the second polymerization reaction and solidifies by irradiation with ultraviolet rays (intensity is 4 mW / cm ² ) for 30 minutes. After 30 minutes of polymerization and solidification, the female mold and male mold are separated, and the composition after solidification is a contact lens, attached to the female mold or male mold, and soaked with 50% IPA. Drop off the mold. Thereafter, it is washed 3 times with 50% IPA, each time for 20 minutes, then immersed in 25% IPA for 20 minutes, then washed 3 times with pure water, each time for 20 minutes. After the cleaning step, the contact lens is dipped and mounted in a phosphate buffer.

  In the above-mentioned third embodiment of the present invention, first, the thermal initiator AIBN is used to induce a copolymerization reaction of the monomer NVP not containing hydrophilic silicon and the cross-linking agent IEM (forms the reaction product 3A). Silicone-free monomer NVP, terminator MEHQ (forming reactant 3B), and hydrophilic silicon-free monomer HEMA are sequentially added to form a silicon-free polymer. Next, the polymer without polymer containing silicon and the monomer SiGMMA containing silicon are polymerized first, and the polymer without silicon and the monomer SiGMMA containing silicon are polymerized using the crosslinking agent EGDMA, photoinitiator Irgacure 1173, and photoinitiator BAPOs. Reaction and solidification (second polymerization reaction and solidification in step (S3)) are induced to form a solidified composition. Finally, the contact lens is formed by washing.

  Hereinafter, detailed components and steps of the fourth embodiment of the present invention will be described. Since step (S1) of the fourth embodiment is the same as step (S1) of the third embodiment, step (S2) is directly performed. It explains from.

  Step (S2): 4.7451 grams of silicon-free polymer, 4.2024 grams of SiGMMA, 0.9967 grams of TRIS (product number used in this example is FM0711), 0.0528 grams of EGDMA, A composition is formed by mixing 0.0155 grams of Irgacure 1173 and 0.9102 grams of l-hexanol and stirring the above mixture in a dark environment for 1 hour.

Step (S3): About 50 μL of the composition is left in a clean polypropyne female mold, and then a pressure is applied over the corresponding male mold to form a contact lens-shaped composition. We will react and solidify. In this example, the composition is solidified by irradiation with ultraviolet rays (intensity is 4 mW / cm ² ) for 30 minutes. After 30 minutes of polymerization and solidification, the female mold and male mold are separated, and the composition after solidification is a contact lens, attached to the female mold or male mold, and soaked with 50% IPA. Drop off the mold. Thereafter, it is washed 3 times with 50% IPA, each time for 20 minutes, then immersed in 25% IPA for 20 minutes, then washed 3 times with pure water, each time for 20 minutes. After the cleaning step, the contact lens is dipped and mounted in a phosphate buffer.

  In the above-mentioned fourth embodiment of the present invention, first, a polymerization reaction of monomer NVP not containing hydrophilic silicon (formation of reaction product 4A) is induced using a crosslinking agent IEM and a thermal initiator AIBN to form hydrophilic silicon. Monomer NVP not containing, terminator MEHQ (forming reactant 4B) and monomer HEMA not containing hydrophilic silicon are sequentially added to form a polymer containing no silicon. Next, using the photoinitiator Irgacure 1173, first polymerized polymer containing no silicon, silicon containing monomer SiGMMA, silicon containing macromer TRIS and crosslinker EGDMA polymerization reaction and solidification (mixing of step (S2) and step ( S3) second polymerization reaction and solidification) are induced and solidified to form a lens. Finally, after cleaning, contact lenses (l-hexanol is only used as a solvent) are formed.

  Hereinafter, detailed components and steps of the fifth embodiment of the present invention will be described.

  Step (S1): 11.85 grams of LM, 30.69 grams of HEMA, 21.66 grams of DMA, 0.69 grams of l-decanethiol, 34.44 grams of ethyl lactate and 0.39 grams of AIBN. By adding to a 250 mL beaker and stirring for 1 hour, AIBN is completely dissolved to form a clear reactant 5A. Reactant 5A is heated in an oil bath with a 250 mL beaker and the temperature of reactant 5A is increased from 55 ° C. to 64 ° C. within 1 hour, and the temperature of reactant 5A is allowed to reach equilibrium at 64 ° C. to 66 ° C. The polymerization reaction is carried out by maintaining at 3 ° C. for 3 hours. The reactant 5A is transferred to a 25 ° C. water bath, and the temperature of the reactant 5A is lowered to 40 ° C. or lower to form a sticky reactant 5A. The sticky reactant 5A is transferred to an environment of 4 ° C. to 10 ° C. and left to cool for 24 hours. Finally, 4.31 grams of IEM is added to reactant 5A, stirred under an environment of 25 ° C. and mixed for 8 hours to form a silicon free polymer.

  Step (S2): 1.99778 grams of silicon-free polymer, 1.4819 grams of SiGMMA, 0.6345 grams of DMA, 0.3563 grams of HOBMA, 0.1174 grams of EGDMA and 0.1615 grams of Irgacure 1173 And the above mixture is stirred in a dark environment for 1 hour to form a composition.

Step (S3): After leaving about 50 μL of the composition in a clean polypropyne female mold, pressure is applied over the corresponding male mold to form the composition into a contact lens shape prior to solidification molding. . In the solidification step of this example, the composition is solidified by irradiation with ultraviolet rays (intensity is 4 mW / cm ² ) for 30 minutes. After solidification for 30 minutes, the female mold and male mold are separated, and the composition after solidification is a contact lens, attached to the female mold or male mold, and soaked with 50% IPA from the female mold or male mold. take off. Thereafter, it is washed 3 times with 50% IPA, each time for 20 minutes, then immersed in 25% IPA for 20 minutes, then washed 3 times with pure water, each time for 20 minutes. After the cleaning step, the contact lens is dipped and mounted in a phosphate buffer.

  In the fifth embodiment of the present invention, first, polymerization reaction (reactant) of monomer LM not containing hydrophobic silicon, monomer DMA not containing hydrophilic silicon, monomer HEMA not containing hydrophilic silicon using thermal initiator AIBN. 5A is formed) followed by the addition of crosslinker IEM to form a silicon free polymer. Next, polymerized silicon-free polymer, silicon-containing monomer SiGMMA, hydrophilic silicon-free monomer DMA and hydrophilic silicon-free monomer HOBMA are polymerized, and the cross-linker EGDMA and initiator Irgacure 1173 are used to form silicon. Polymerization and solidification (second polymerization reaction and solidification in step (S3)) of the polymer not containing, the monomer SiGMMA containing silicon, the monomer DMA containing no hydrophilic silicon and the monomer HOBMA containing no hydrophilic silicon are induced. Finally, it is washed to form contact lenses (l-decanethiol and ethyl lactate are only used separately as chain transfer reagent and solvent).

  In the above-described embodiments of the present invention, all of the above components are first polymerized to form a silicon-free polymer, and then polymerized with at least one silicon-containing component to form a composition. Select any one or combination of at least one initiator, at least one crosslinking agent, at least one termination agent in any one or combination in S1), step (S2), step (S3) Can join. In other embodiments, other required reagents can be added at an appropriate time depending on the situation, for example, chain transfer reagents. In the method according to the present invention, the weight percentage of the non-hydrophilic silicon-containing component is higher than the non-hydrophobic silicon-containing component, and the silicon-free component can be selectively included in step (S2), or first the silicon-containing component is included. After the polymerization, the second polymerization reaction is performed with the polymer not containing silicon formed in step (S1).

  In order to make the effects of the present invention prominent, the first comparative example to the third comparative example are provided below, the comparison results explain the distinction between the comparative examples and the examples of the present invention, and the effects of the present invention are further clarified. .

  Hereinafter, a first comparative example of the present invention will be described.

Mix 1.0205 grams of NVP, 0.1897 grams of HOBMA, 0.5138 grams of SiGMMA, 0.0275 grams of EGDMA and 0.0219 grams of Irgacure 1173, then stir in a dark environment for 1 hour. Form things. About 50 μL of the composition is left in a clean polypropyne female mold and then pressure is applied over the corresponding shaped male mold to form a contact lens shaped composition. In the solidification step of this example, the composition is solidified by irradiation with ultraviolet rays (intensity is 4 mW / cm ² ) for 30 minutes. After solidification for 30 minutes, the female mold and male mold are separated, and the composition after solidification is a contact lens, attached to the female mold or male mold, and soaked with 50% IPA from the female mold or male mold. take off. Thereafter, it is washed 3 times with 50% IPA, each time for 20 minutes, then immersed in 25% IPA for 20 minutes, then washed 3 times with pure water, each time for 20 minutes. After the cleaning step, the contact lens is soaked in a phosphate buffer and mounted before being sold.

  The main component content of the first comparative example described above is the same as that of the first embodiment of the present invention. However, when polymerizing, a component not containing silicon is not polymerized first, and a component not containing silicon is directly mixed with a component containing silicon. Polymerization and solidification.

  Hereinafter, a second comparative example of the present invention will be described.

  4. Mix 40,049 grams of NVP, 0.9509 grams of HEMA, 4.4948 grams of SiGMMA, 0.0545 grams of EGDMA and 0.0871 grams of AIBN, then stir in a dark environment for 1 hour Form. About 50 μL of the composition is left in a clean polypropyne female mold and pressure is applied over the corresponding shaped male mold to form the composition into a contact lens shape prior to solidification. In the solidification step of this example, the composition is left in an environment of 120 ° C. for 30 minutes and molded using a heat solidification method. After solidification for 30 minutes, the female mold and male mold are separated, and the composition after solidification is a contact lens, attached to the female mold or male mold, and soaked with 50% IPA from the female mold or male mold. take off. Thereafter, it is washed 3 times with 50% IPA, each time for 20 minutes, then immersed in 25% IPA for 20 minutes, then washed 3 times with pure water, each time for 20 minutes. After the cleaning step, the contact lens is soaked in a phosphate buffer and mounted before being sold.

  The main component of the second comparative example described above is the same as that of the second embodiment of the present invention. However, when polymerization is performed, a component not containing silicon is not polymerized first, and a component not containing silicon is directly mixed with a component containing silicon. Then polymerize.

  The third comparative example of the present invention will be described below.

3.35173 grams of NVP, 0.7859 grams of HEMA, 3.6120 grams of SiGMMA, 0.0447 grams of EGDMA, 0.0652 grams of Irgacure 1173 and 0.0319 grams of BAPOs in a dark environment Stir in 1 hour to form the composition. About 50 μL of the composition is left in a clean polypropyne female mold and pressure is applied over the corresponding shaped male mold to form the composition into a contact lens shape prior to solidification. In the solidification step of this example, the composition is solidified by irradiation with ultraviolet rays (intensity is 4 mW / cm ² ) for 30 minutes. After solidification for 30 minutes, the female mold and male mold are separated, and the composition after solidification is a contact lens, attached to the female mold or male mold, and soaked with 50% IPA from the female mold or male mold. take off. Thereafter, it is washed 3 times with 50% IPA, each time for 20 minutes, then immersed in 25% IPA for 20 minutes, then washed 3 times with pure water, each time for 20 minutes. After the cleaning step, the contact lens is soaked in a phosphate buffer and mounted before being sold.

  The main component content of the third comparative example described above is the same as that of the third embodiment of the present invention, but the polymerization was divided into two steps when polymerized.

A Sudan stain is a kind of organic compound that is artificially synthesized, and is mainly used to stain a specific biological sample of Sudan. For example, it is a lipid. Examples of common Sudan stains include Sudan II (Sudan II, C ₁₈ H ₁₆ N ₂ O), Sudan III (Sudan III), Sudan IV (Sudan IV, C ₂₄ H ₂₀ N ₄ O), Oil Red O (or Oil Red 27, Sudan 5B, C ₂₆ H ₂₄ N ₄ O), Sudan Black B (C ₂₉ H ₂₄ N ₆ ) and the like.

  Hereinafter, the hydrophobic part on the contact lens and the distribution state thereof are judged by the Sudan black dyeing test (Sudan black test) to embody the possible oil adhesion state.

  Test method: (1) About 5% of the test lens in a solution containing Sudan Black B stain (Sudan Black B stain accounts for 3 wt%, IPA accounts for 70 wt%, and oleic acid accounts for 27 wt%). Soak for ~ 7 seconds. (2) After removing the test lens from the solution, the test lens is left in pure water and stirred while gently shaking for about 5 seconds to wash the remaining Sudan Black B stain.

  Judgment method: After dyeing, if there are more black parts in the contact lens, it means that there are more hydrophobic parts in the test lens, oil will easily adhere to the test lens, and the wetness of the test lens will be maintained This means that there are fewer hydrophilic parts, and therefore dryness problems are more likely to occur.

  Test results: shown in FIGS.

  As shown in FIG. 2, it is a 1st comparative example and a 1st Example from the top to the bottom. Compared to the first embodiment of the present invention, there is clearly a large black portion in the first comparative example, but the first embodiment still remains almost completely transparent even after passing the staining test.

  As shown in FIG. 3, the left side is the second embodiment of the present invention, and the right side is the second comparative example. Compared to the second embodiment of the present invention, there is clearly a large black portion in the second comparative example, but the second embodiment still remains almost completely transparent even after passing the staining test.

  As shown in FIG. 4, the left side is the third embodiment of the present invention, and the right side is the third comparative example. The test results are the same as the results of FIGS. 2 and 3 and will not be described in detail here.

  FIG. 5 and FIG. 6 show the test results of the fourth and fifth embodiments of the present invention separately. In the fourth embodiment, even after passing the dyeing test, it remains almost completely transparent. Compared with the fourth embodiment, the test lens of the fifth embodiment has a slight amount of staining agent, but still has a clear transparency compared to the first to third comparative examples.

  The present invention has been specifically described above based on the embodiments. However, the present invention is not limited to the above-described embodiments, and it goes without saying that various modifications can be made without departing from the scope of the present invention. Thus, the protection scope of the present invention is determined from the following claims.

  S1-S3 step

Claims (27)

Performing a first polymerization reaction on at least one silicon-free component to form a silicon-free polymer (S1);
Mixing the non-silicon-containing polymer and at least one silicon-containing component to form a composition (S2);
Performing a second polymerization reaction on the composition and solidifying (S3);
A method for producing a silicone hydrogel used in ophthalmology, comprising:   The method for producing a silicone hydrogel used in ophthalmology according to claim 1, wherein the first polymerization reaction is performed under an environment of 40 ° C to 100 ° C.   The method for producing a silicone hydrogel used for ophthalmology according to claim 2, wherein the first polymerization reaction is performed under an environment of 50C to 90C.   The method for producing a silicone hydrogel used in ophthalmology according to claim 3, wherein the first polymerization reaction is performed under an environment of 55 ° C to 80 ° C.   The method for producing a silicone hydrogel used in ophthalmology according to claim 1, wherein the reaction time of the first polymerization reaction is 10 minutes to 72 hours.   The method for producing a silicone hydrogel used in ophthalmology according to claim 5, wherein the reaction time of the first polymerization reaction is 25 minutes to 24 hours.   The method for producing a silicone hydrogel used in ophthalmology according to claim 6, wherein the reaction time of the first polymerization reaction is 40 minutes to 12 hours.   The method for producing a silicone hydrogel used in ophthalmology according to claim 1, wherein the reaction time for the second polymerization reaction and the solidification is 20 minutes to 2 hours.   The method for producing a silicone hydrogel used in ophthalmology according to claim 8, wherein the reaction time for the second polymerization reaction and the solidification is 25 minutes to 35 minutes.   The method for producing a silicone hydrogel used in ophthalmology according to claim 9, wherein the reaction time for the second polymerization reaction and the solidification is within 30 minutes.   The method for producing a silicone hydrogel used in ophthalmology according to claim 1, wherein the silicon-free component comprises at least one silicon-free monomer, and the molecular weight of the silicon-free monomer is less than 700.   The method for producing a silicone hydrogel used in ophthalmology according to claim 1, wherein the silicon-free component comprises at least one kind of silicon-free macromer, and the molecular weight of the silicon-free macromer is greater than 700.   2. The method for producing a silicone hydrogel used in ophthalmology according to claim 1, wherein a weight percentage of the composition occupied by the silicon-containing component is 6 to 80 wt%.   The method for producing a silicone hydrogel used in ophthalmology according to claim 13, wherein a weight percentage of the composition occupied by the silicon-containing component is 14 to 65 wt%.   The method for producing a silicone hydrogel for use in ophthalmology according to claim 14, wherein a weight percentage of the composition occupied by the silicon-containing component is 21 to 51 wt%.   The method for producing a silicone hydrogel used in ophthalmology according to claim 1, wherein a weight percentage of the composition occupied by the silicon-free component is 15 to 86 wt%.   The method for producing a silicone hydrogel for use in ophthalmology according to claim 16, wherein the weight percentage of the composition occupied by the silicon-free component is 18 to 61 wt%.   The method for producing a silicone hydrogel for use in ophthalmology according to claim 17, wherein the weight percentage of the composition occupied by the silicon-free component is 25 to 56 wt%.   The silicon-free component comprises a component free of hydrophilic silicon and a component free of hydrophobic silicon, and the weight percentage of the composition occupied by the component free of hydrophilic silicon is the composition of the component free of hydrophobic silicon The method for producing a silicone hydrogel used in ophthalmology according to claim 1, wherein the method is more than a percentage by weight. The step (S2)
Performing a third polymerization reaction on the at least one silicon-containing component to form a silicon-containing polymer (S21);
Mixing the non-silicon-containing polymer and the silicon-containing polymer to form the composition (S22);
The manufacturing method of the silicone hydrogel used for the ophthalmology of Claim 1 characterized by the above-mentioned.   2. The composition according to claim 1, wherein in the step (S <b> 2), the other one silicon-free component, the silicon-free polymer, and the at least one silicon-containing component are mixed to form the composition. A method for producing a silicone hydrogel used in ophthalmology.   The silicone hydrogel used in ophthalmology according to claim 1, wherein in the step (S1), the first polymerization reaction is performed by adding at least one initiator to the at least one silicon-free component. Manufacturing method.   The silicone hydrogel used in ophthalmology according to claim 1, wherein in the step (S1), the first polymerization reaction is performed by adding at least one crosslinking agent to the at least one kind of silicon-free component. Manufacturing method.   The ophthalmologic according to claim 1, wherein, in the step (S2), the composition is formed by mixing the non-silicon-containing polymer, the at least one silicon-containing component, and at least one initiator. A method for producing a silicone hydrogel used.   The ophthalmology according to claim 1, wherein in the step (S2), the composition is formed by mixing the non-silicon-containing polymer, the at least one silicon-containing component, and at least one crosslinking agent. A method for producing a silicone hydrogel used.   The method for producing a silicone hydrogel used in ophthalmology according to claim 1, wherein in the step (S3), the composition is solidified by using a photo-solidification method.   The method for producing a silicone hydrogel used in ophthalmology according to claim 1, wherein in the step (S3), the composition is solidified using a heat solidification method.

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