JP2017015638A - Mo ABSORBENT AND 99mTc GENERATOR COLUMN - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a Mo absorbent constituted by elements easy to have an approval by pharmaceutical affairs low while constitutional elements is equal to conventional ones andTc manufacturing method and quality are equal and capable of maintaining small sized form of aTc generator.SOLUTION: A CAO based Mo absorbent with CaMo(Mo)Obound to oxide consisting of Ca and Al (hereafter CAO) or an alumina-based Mo absorbent with CaMo(Mo)Obound to alumina is used.SELECTED DRAWING: Figure 3

Description

  The present invention relates to a Mo adsorbent and a 99mTc generator column (TcGC).

To separate ^99m Tc from ⁹⁹ Mo, there are currently methods such as alumina method, sol-gel method, MEK method, sublimation method, and PZC method. Uranium to produce ⁹⁹ Mo with fission method as a raw material, to separate production of ^99m Tc from its ⁹⁹ Mo, alumina Act was established as the only practical technology widely, the formulation and the generator of the ^99m Tc for diagnosis It is commercially available. The sol-gel method uses natural Mo (n, γ) ⁹⁹ Mo as a raw material, but mass production of a ^99m Tc solution is difficult, and it cannot be downsized to the size of a commercially available ^99m Tc generator column. There is a problem and it is in a situation where it is not put into practical use. The MEK method has a quality problem because it uses an organic solvent, and is difficult in principle to be a ^99m Tc generator. The sublimation method uses ⁹⁹ Mo produced by the natural Mo (n, γ) method or the ¹⁰⁰ Mo (γ, n) method, but has the same problems as the sol-gel method and the MEK method. The PZC method uses natural Mo (n, γ) ⁹⁹ Mo, but still has the same problems as the sol-gel method.

Patent Document 1 describes an alumina column on which ⁹⁹ Mo, which is a parent nuclide, is adsorbed.

Patent Document 2 describes that ZrO ⁹⁹ MoO ₄ .XH ₂ O is synthesized and packed in a column to elute ^99m Tc.

  Patent Document 3 describes a 99Mo / 99mTc generator column in which a column is filled with an adsorbent in the form of Al2O3-SO4 or Al2O3-ZrO2-SO4.

Patent Document 4 describes a method in which a ⁹⁹ Mo solution is passed through activated carbon, the adsorbed ^99m Tc is eluted, and purified and recovered with alumina.

Japanese Patent No. 3831724 JP-A-8-309182 USP8758814B2 publication Japanese Patent No. 5427483

To produce a ^99m Tc generator column using the natural Mo (n, γ) method or the ¹⁰⁰ Mo (γ, n) method under the circumstances where it is difficult to use the uranium fission method for producing ⁹⁹ Mo, a high Mo It is not enough to have adsorptive capacity. In addition to being downsized to the size of the ^99m Tc generator column used in the alumina method, it is required that radiopharmaceutical standards (drug group) can be cleared. It is done. An important issue in domestic production of the ^99m Tc generator column is that it is equivalent to the constituent elements of the conventional product, has the same ^99m Tc manufacturing method and quality, and is easy to obtain pharmaceutical approval. For that purpose, elements equivalent to the constituent elements of the conventional products are used, and it is required that the Mo adsorbent is composed of elements that are easy to obtain pharmaceutical approval while having the same ^99m Tc manufacturing method and quality. Although In the ^{99m Tc} generator column which is described in the above-mentioned documents has excellent characteristics for the preparation and quality, a Mo adsorbent regulatory approval is composed of easily obtained element, ^{99m Tc} generator It cannot be said that the column structure is miniaturized.

In view of this point, the present invention is a Mo adsorbent composed of elements that are easy to obtain pharmaceutical approval while being equivalent to the constituent elements of the conventional product and having the same ^99m Tc manufacturing method and quality. It aims at providing Mo adsorption agent which makes it easy to set it as the small form ^99m Tc generator column which is easy to obtain.

  Claim 1 relates to the CAO-based Mo adsorbent and has the following configuration.

CAMO ⁽⁹⁹ Mo) _{0 4} oxide consists of Ca and Al CAO based Mo adsorbent coupled to (hereinafter, referred to. CAO).
The second aspect relates to the CAO-based Mo adsorbent and has the following configuration.

2. The CAO-based Mo adsorbent according to claim 1, wherein a sulfate is further bonded to CAO.
The third aspect relates to the alumina-based Mo adsorbent and has the following configuration.

CaMo ⁽⁹⁹ Mo) _{0 4} Alumina based Mo adsorbent coupled to alumina.
The fourth aspect relates to the alumina-based Mo adsorbent and has the following configuration.

The alumina-based Mo adsorbent according to claim 3, wherein the sulfate is further bonded to alumina.
Claim 5 relates to a CAO-based ^99m Tc generator column and has the following configuration.

A built-in alumina based Mo adsorbent according to CAO base Mo adsorbent or claim 3 according to claim ^{1, 99m} Tc generator column to produce the ^99m Tc by adsorbing ^{Mo (99} Mo).
Claim 6 relates to an alumina-based ^99m Tc generator column having the following configuration.

The ^99m Tc generator column which manufactures ^99m Tc of Claim 5 ^{WHEREIN: The 99m} Tc generator column by which the sulfate salt was couple ^| bonded with CAO or alumina of CAO base Mo adsorbent or alumina base Mo adsorbent built in.

Claim 7 relates to a CAO-based ^99m Tc generator column and has the following configuration.

Volume 2~3cc capacity of Mo adsorbent packed column ^99m Tc generator column which is commercially available is maintained, a layer of CAO base Mo ^{adsorbent CaMo} (99 Mo) _{0 4} is coupled to the CAO is the 2~3cc A ^99m Tc generator column, packed in a capacity Mo adsorbent column and loaded on a layer of CAO-based Mo adsorbent up to 500 mg Mo without containing other heavy metal elements.
Claim 8 relates to an alumina-based ^99m Tc generator column having the following configuration.

2~3cc capacity of the volume of Mo adsorbent packed column ^99m Tc generator column which is commercially available is maintained, a layer of alumina ^CaMo (99 Mo) _{0 4} is bonded alumina-based Mo adsorbent, the 2 A ^99m Tc generator column formed in a 3 cc capacity Mo adsorbent packed column and having a maximum of 500 mg Mo supported on an alumina-based Mo adsorbent layer without containing other heavy metal elements.

The present ^{invention, CaMo} (99 Mo) _{0 4} forms a Mo adsorbent bound Mo adsorbent or ^CaMo (99 Mo) _{0 4} is coupled to the alumina oxide comprising Ca and Al, also one since using the Mo adsorbent forms a ^{99m Tc} generator column, can be a ^{99m Tc} generator column as claimed in claim 7 or claim 8, comprising the same as constituent elements of a conventional ^99m Mo adsorption that is produced by an element that is easy to obtain regulatory approval, with the same Tc manufacturing method and quality, and that makes it easy to obtain a small- ^{sized 99m} Tc generator column that is easy to obtain regulatory approval Agent can be provided.

^The figure which shows the outline ^| summary which manufactures ^99m Tc generator column 100. FIG. Ca-Al-Oxide-SO ₄ Synthesis and ^{Mo (99} Mo) shows adsorption ^99m Tc elution principles. CaSO ₄ on alumina synthesis and ^{Mo (99} Mo) shows adsorption ^99m Tc elution principles. Diagram showing the principle of a Mo adsorbent and Tc generator column consisting of CaSO ₄ on alumina. The figure which shows the experimental result using the alumina base Mo adsorbent shown by FIG. The figure which shows the experimental result using the alumina base Mo adsorbent shown by FIG. Natural Mo (n, ^γ) shows a summary of 99 Mo- alumina-based ^99m Tc generator column. ^The figure which shows the structure of ^99m Tc generator column 100. FIG. The figure which shows an alumina base Mo adsorbent preparation and the ^99m Tc generator column preparation process using this adsorbent.

  Embodiments of the present invention will be described below with reference to the drawings.

FIG. 1 is a diagram showing an outline of manufacturing a ^99m Tc generator column 100.

In FIG. 1, the ^99m Tc generator column 100 is manufactured and supplied with ⁹⁹ Mo production 1,
⁹⁹ Mo solution manufacture and ^99m Tc solution manufacture (TcMM) 2 and ^99m Tc generator column 100 manufacture 3.

⁹⁹ Mo is irradiated with ¹⁰⁰ Mo by a natural isotope ratio Mo or an accelerator in a nuclear reactor,
^nat Mo (n, γ) ⁹⁹ Mo, or
¹⁰⁰ Mo (γ, n) ⁹⁹ Mo
It is manufactured through the reaction of

Next, the Mo ( ⁹⁹ Mo) O ₃ produced in the above-described step is alkali-dissolved to obtain a solution of Na ₂ Mo ( ⁹⁹ Mo) O ₄ . A part of this Na ₂ Mo ( ⁹⁹ Mo) O ₄ solution is separated from the ^99m Tc solution by the TcMM method and used as a raw material for injections, and is used as a diagnostic agent for bone diseases, brain tumors, cerebrovascular disorders, and many others.

Another part of the Na ₂ Mo ( ⁹⁹ Mo) O ₄ solution is used for ^99m Tc generator column production.

In this step, Mo ( ⁹⁹ Mo) O _x / AL is produced. Mo ( ⁹⁹ Mo) based on alumina is stored in a ^99m Tc generator column 100. Here, AL represents alumina.

In the case of the present ^{invention, Mo (99} Mo) ^{is, CAMO} (99 Mo) _{0 4} oxide consists of Ca and Al are CAO based Mo adsorbent coupled to (hereinafter, referred to. CAO), or CAMO ( ⁹⁹ Mo) _{0 4} is alumina-based Mo adsorbent coupled to alumina. A generator column is filled with a CAO-based Mo adsorbent in which CaMo ( ⁹⁹ Mo) 0 ₄ is bonded to CAO or an alumina-based Mo adsorbent in which CaMo ( ⁹⁹ Mo) 0 ₄ is bonded to alumina, and the ^99m Tc generator column 100 Become.

At this time, the volume 2~3cc capacity of Mo adsorbent packed column ^99m Tc generator column which is commercially available is maintained, a layer of CAO base Mo ^{adsorbent CaMo} (99 Mo) _{0 4} is coupled to the CAO is the A ^99m Tc generator column formed in a 2-3 cc capacity Mo adsorbent packed column and having a maximum of 500 mg Mo supported on a CAO-based Mo adsorbent layer without containing other heavy metal elements There is constructed, or volume 2~3cc capacity of Mo adsorbent packed column ^99m Tc generator column which is commercially available is maintained, a layer of CAO base Mo ^{adsorbent CaMo} (99 Mo) _{0 4} is coupled to the CAO is , Formed in the 2-3 cc capacity Mo adsorbent packed column, and up to 500 mg Mo contains other heavy metal elements It not, ^99m Tc generator column 100 is configured, characterized in that it is supported on a layer of CAO base Mo adsorbent.

^A layer made of Al ₂ O ₃ for purification (acidic alumina) is provided at the bottom of the ^99m Tc generator column 100. ^99m Tc generator saline from the top of the column 100 (Saline) was ^introduced, 99 ^99m Tc generated from Mo are separated by saline, impurities are removed by purification acidic the Al ₂ O ₃ layer, from the lower end ^99m Tc is removed.

^{The 99m} Tc generator column 100 is used for hospital installation.

FIG. 2 is a diagram showing a Ca—Al—Oxide—SO ₄ synthesis method and Mo ( ⁹⁹ Mo) adsorption ^99m Tc elution principle.

In FIG. 2, Ca (OH) ₂ and aluminum (Al) are prepared as raw materials. These two raw materials are wet-synthesized and granulated. As shown in the figure, Ca—Al—Oxide grains are formed. As described above, an oxide composed of Ca and Al is called CAO.

A process of adsorbing SO ₄ on this CAO is performed.

By this treatment, CAO-SO ₄ grains are formed as shown in the figure.

Mo ( ⁹⁹ Mo) is adsorbed on the CAO—SO ₄ grains. This adsorption produces CAO-Mo ( ⁹⁹ Mo) O ₄ as shown in the figure. That ^CaMo (99 Mo) _{0 4} is CAO based Mo adsorbent coupled to CAO- is formed. In the form of this CAO-based Mo adsorbent, a CAO-based Mo adsorbent in which sulfate is further bonded to CAO may be used.

The column is filled with CAO-Mo ( ⁹⁹ Mo) O ₄ to form a ^99m Tc generator column 100.

As shown in the figure, from ⁹⁹ Mo to ^{99 m} Tc in a state in which -Al-O-Ca = Mo ( ⁹⁹ Mo) O ₄ and -Al-O-Ca-Mo ( ⁹⁹ Mo) O ₄ are formed on the basis of CAO. There is generated _{^{-Al-O-Ca- 99m TcO 4}} - is produced. ^99m TcO ₄ ⁻ is eluted when saline is introduced, and recovered and removed as ^99m TcO ₄ ⁻ . This operation is referred to as milking and is repeated for as long as effective ⁹⁹ Mo radioactivity remains.
The Al: Ca mol ratio, Ca: Al, Al: Ca mol ratio, Al + Ca (OH) ₂ (g) and reaction formula in these steps are as follows. Also shown in the figure.

(Reaction formula)
2Ca (OH) ₂ + Al + 3H ₂ O → Ca ₂ Al (OH) ₇ + 1.5H ₂
Ca ₂ Al (OH) ₇ {= 2Ca (OH) ₂ + Al (OH) ₃ + 2Na ₂ SO ₄ → Ca ₂ Al (SO ₄ ) ₂ (OH) ₃ {= 2CaSO ₄・ Al (OH) ₃ }
+ 4NaOH

FIG. 3 is a diagram showing a CaSO ₄ -supported alumina synthesis method and Mo ( ⁹⁹ Mo) adsorption ^99m Tc elution principle.

  As shown in the figure, alumina particles are prepared.

The alumina (AL) grains are subjected to H ₂ SO ₄ treatment and CaCl ₂ treatment.

By this treatment, Ca SO ₄ / AL grains are formed as shown in the figure. Mo ( ⁹⁹ Mo) is adsorbed on the Ca SO ₄ / AL grains. By this adsorption, Ca Mo ( ⁹⁹ Mo) O ₄ / AL is generated as shown in the figure. That ^CaMo (99 Mo) _{0 4} alumina-based Mo adsorbent coupled to alumina is formed. This alumina-based Mo adsorbent may be an alumina-based Mo adsorbent in which sulfate is further bonded to alumina.

CaMo ( ⁹⁹ Mo) 0 ₄ / AL is layered and housed in the column to form a ^99m Tc generator column 100.

As a base of alumina as shown in the figure, from -Al-O-Ca = Mo ( 99 Mo) O 4 further in a state where ^{-Al-O-Ca- Mo (99} Mo) O 4 is formed, and ^{99 Mo 99m} Tc is generated _{^{-Al-O-Ca- 99m TcO 4}} - is produced. ^99m TcO ₄ ⁻ is eluted when saline is introduced, and is eluted and recovered and removed as ^99m TcO ₄ ⁻ . Milking is repeated and elution is repeated.

The reaction formula is as follows.
(Reaction formula)
Al2O3 + H2SO4 → AlxOy- (SO4) 2 (OH) 3 / AL
AlxOy- (SO4) 2 (OH) 3 / AL + CaCl2 → AlxOy-CaSO4 / AL
AlxOy-CaSO4 / AL + Na2MoO4 → AlxOy-CaMoO4 / AL

FIG. 4 is a diagram showing the principle of a Mo adsorbent composed of CaSO ₄ -supported alumina and a ^99m Tc generator column.

As shown in the figure, supporting alumina particles are prepared. Ca SO _{4 is} supported on the supporting alumina particles. A Ca 2 SO ₄ -supported alumina having a central portion of AL and a surface layer of CaSO ₄ / AL is formed. When Mo ( ⁹⁹ Mo) is adsorbed,
CaSO ₄ / AL + Na ₂ Mo ( ⁹⁹ Mo) 0 ₄ → CaMo ( ⁹⁹ Mo) 0 ₄ / AL + Na ₂ SO ₄
^CaMo (99 Mo) _{0 4} produced by Scheme of surface supported Mo ⁽⁹⁹ Mo) adsorption alumina is formed.

^CaMo supported on alumina surface (99 Mo) _{0 4} of ⁹⁹ Mo from ^99m Tc is generated. ^99m Tc, when saline is introduced, is ^eluted, 99m TcO ₄ ^- eluted is recovered as. This milking operation is repeated for as long as effective ⁹⁹ Mo radioactivity remains.

  FIG. 5 shows the experimental results using the alumina-based Mo adsorbent shown in FIG. In this example, an alumina-based Mo adsorbent called SC-KDH-12 basic 8-14 mesh was used.

The Mo adsorption capacity was 90 to 140 mg / 2 cc, and the ^99m Tc elution rate was 50 to 60%. The ^99m Tc elution rate with respect to the number of milking in this case and the ^99m Tc recovery rate for every 10 ml of milking with respect to the number of times of milking (times) are as shown in the figure.

  FIG. 6 shows the experimental results using the alumina-based Mo adsorbent shown in FIG. In this example, an alumina-based Mo adsorbent called MP # 02028 basic 0.5-1 mm was used.

The Mo adsorption capacity was 30 to 46 mg / 2 cc, and the ^99m Tc elution rate was 85 to 100%. The ^99m Tc elution rate with respect to the number of milking in this case and the ^99m Tc recovery rate for every 10 ml of milking with respect to the number of times of milking (times) are as shown in the figure.

FIG. 7 shows a summary of a ^nat Mo (n, γ) ⁹⁹ Mo-alumina based ^99m Tc generator column.

  The results shown in FIGS. 5 to 7 were obtained for the examples shown in FIGS.

According to these ^{results, CaMo} (99 Mo) _{0 4} forms an alumina-based Mo adsorbent coupled CAO based Mo adsorbent or ^CaMo (99 Mo) _{0 4} is coupled to the alumina CAO, also one since forming the ^{99m Tc} generator column with Kano Mo adsorbent can be a ^{99m Tc} generator column as claimed in claim 7 or claim 8, it was equivalent to the constituent elements of the conventional product The ^99m Tc production method and quality are the same, but it is an Mo adsorbent composed of elements that are easy to obtain pharmaceutical approval, making it easy to make a small- ^{sized 99m} Tc generator column that is easy to obtain pharmaceutical approval. Mo adsorbent can be provided.

The ^99m Tc generator column described in claim 7 or claim 8 is as follows.

FIG. 8 shows a configuration of a ^99m Tc generator column 100 using this adsorbent.

The ^99m Tc generator column 100 shown in FIG.
Volume 2~3cc capacity of Mo adsorbent packed column ^99m Tc generator column which is commercially available is maintained, a layer of CAO base Mo ^{adsorbent CaMo} (99 Mo) _{0 4} is coupled to the CAO is the 2~3cc A ^99m Tc generator column, which is formed in a capacity-packed Mo adsorbent packed column and is supported on a CAO-based Mo adsorbent layer without containing other heavy metal elements, or a commercially available ^{99 m} Tc generator column. which is 2~3cc volume of the volume of the Mo adsorbent packed column ^99m Tc generator column which has maintenance is a layer of alumina ^CaMo (99 Mo) _{0 4} is bonded alumina-based Mo adsorbent, the 2~3cc Formed in a column packed with Mo adsorbent with a capacity of up to 500 mg Mo without other heavy metal elements, It shows the ^{99m Tc} generator column which is characterized in that it is supported on a layer of alumina-based Mo adsorbent.

With this structure, a ^99m Tc generator column made of Mo adsorbent, which is made of an element that can easily be approved by pharmaceutical affairs, and that can maintain a miniaturized form of the ^99m Tc generator column. Was made. One ^99m Tc generator column may be formed of a layer of CAO-based Mo adsorbent and alumina-based Mo adsorbent.

The ^99m Tc generator column 100 has a structure of _{2 to 3} cc of the volume of the Mo adsorbent packed column in the upper part, the structure is maintained, a layer of Al ₂ O ₃ for purification is provided in the lower part, the outer diameter of the column is 16 mm, The width diameter was suppressed to 20 mm, and the structure suitable for maintaining ^99m Tc elution rate as before was maintained by repeating milking with a small size.

FIG. 9 is a diagram showing preparation of an alumina-based Mo adsorbent and a ^99m Tc generator column preparation process using this adsorbent.

In FIG. 9, 20-50 g of alumina was prepared (S1) and subjected to H ₂ SO ₄ treatment.

After drying at 120 ° C. for 1 hour (S2), it was treated with CaCl ₂ and again dried at 120 ° C. for 1 hour (S3).

Decantation by washing with water was performed three times (S4), and dried again at 120 ° C. for 1 hour to form dried alumina-based Ca 2 SO ₄ / AL grains. (S5)
This was baked at 400 ° C. or 800 ° C. for 1 hour. (S6)
In this way, alumina-based fired Ca 2 SO ₄ / AL grains were formed. (S7)
Mo ( ⁹⁹ Mo) of the Mo adsorbent was adsorbed on the calcined Ca 2 SO ₄ / AL grains, and the process shifted to a step of generating Ca 2 SO ₄ / AL grains.

A generator column 100A prepared with 2 to 3 cc of Ca SO ₄ / AL particles was packed. (S9) Washing with water was performed.

The column was washed with water. (S10) The Mo ( ⁹⁹ Mo) solution was added so that Mo was 200 mg or more, and retained adsorption in the Mo column was performed. (S11)
As a result, 2 to 3 cc of Ca Mo ( ⁹⁹ Mo) O ₄ / AL on which Mo ( ⁹⁹ Mo) was adsorbed was produced. (S12) Water washing / draining was performed, and 2 cc of acidic alumina for purification was set on the top. Next, the generator column 100A was inverted 180 degrees.

As a result, a ^99m Tc generator column 100 (TcGC) was prepared in which 2 to 3 cc of CaMo ( ⁹⁹ Mo) O ₄ / Al was set in the upper stage and acidic alumina (2 cc) for purification was set in the subsequent stage. (S13) ^99m Tc milking was repeated every 24 hours. Saline (saline) was introduced to recover ^99m Tc. (S14) ^99m Tc elution profile (image) was displayed.

For recovered ^{99m Tc,} elution profile of ^{99m Tc, 99m} Tc recovery, leaching components, ^pH, inspection for ^99m Tc form and ^99m Tc radiochemical purity is made.

This process is similar for CAO-based Mo ( ⁹⁹ Mo) adsorption ^99m Tc elution.

According to these processes, the following ^99m Tc generator column forming method is constituted.

Ca (OH) ₂ and aluminum are reacted as raw materials, granulated to form CAO grains, calcium sulfate-supporting treatment for supporting calcium sulfate is performed to form calcium sulfate-supporting CAO grains, and calcium sulfate-supporting CAO grains are formed. A CAO-based Mo adsorbent in which Mo ( ⁹⁹ Mo) is adsorbed to form CaMo ( ⁹⁹ Mo) 0 ₄ is formed, and a CAO-based Mo adsorbent layer formed from the CAO-based Mo adsorbent is incorporated. A method of forming a ^99m Tc generator column that produces ^99m Tc from ⁹⁹ Mo in a base Mo adsorbent.

Alumina particles to form a particle of calcium sulfate-supported alumina by performing calcium sulfate carrying process for carrying calcium sulfate, coupled CaMo (99 ^Mo) 0 ₄ is to adsorb Mo (99 ^Mo) in particle calcium sulfate on alumina A ^99m Tc generator column that forms ^99m Tc from ⁹⁹ Mo in the alumina-based Mo adsorbent by forming an alumina-based Mo adsorbent formed therein, and an alumina-based Mo adsorbent layer formed from the alumina-based Mo adsorbent. How to form.

Alumina particles are used, and calcium sulfate-supporting treatment for supporting calcium sulfate on the surface of the alumina particles is performed to form calcium sulfate-supporting alumina particles having a surface calcium sulfate-supporting layer, and Mo ( ⁹⁹ Mo ) the adsorbed CaMo (99 ^Mo) 0 ₄ form a bond alumina based Mo adsorbent incorporates an alumina-based Mo adsorbent layer formed from the alumina-based Mo adsorbents, alumina-based Mo adsorbent Of forming a ^99m Tc generator column that produces ^99m Tc from ⁹⁹ Mo therein.

Ca (OH) ₂ and aluminum are reacted as raw materials, granulated to form CAO grains, calcium sulfate-supporting treatment for supporting calcium sulfate is performed to form calcium sulfate-supporting CAO grains, and calcium sulfate-supporting CAO grains are formed. Low specific activity Mo ( ⁹⁹ Mo) produced by the nuclear reaction of natural Mo- ⁹⁸ Mo (n, γ) ⁹⁹ Mo or ¹⁰⁰ Mo (γ, n) ⁹⁹ Mo is adsorbed to cause CaMo ( ⁹⁹ Mo) 0 ₄ ^99m Tc but which forms a combined CAO based Mo adsorbent built CAO base Mo adsorbent layer formed from the alumina-based Mo adsorbent to produce a ^99m Tc from ⁹⁹ Mo in CAO base Mo adsorbent forming a generator column, desorbing the ^{Mo (99} Mo) was passed through the Mo desorbent alkali such as NaOH to CAO base Mo adsorbent layer, collecting Recycled as a raw material ^{Te, Mo (99 Mo)} to desorb the ^99m Tc was passed through a ^99m Tc desorbent after ^{desorption, 99m} Tc elution method for recovering ^99m Tc.

The alumina particles are subjected to a calcium sulfate supporting treatment for supporting calcium sulfate to form calcium sulfate-supporting alumina particles, and the calcium sulfate-supporting alumina particles are subjected to natural Mo- ⁹⁸ Mo (n, γ) ⁹⁹ Mo or ¹⁰⁰ Mo (γ, ⁿ⁾ forming a the ⁹⁹ Mo raw materials produced by the nuclear reaction of low specific activity ^{Mo (99} Mo) is adsorbed by ^CaMo (99 Mo) _{0 4} alumina based Mo adsorbent are combined, the alumina-based Mo An alumina-based Mo adsorbent layer formed from an adsorbent is built in to form a ^99m Tc generator column that generates ^99m Tc from ⁹⁹ Mo in the alumina-based Mo adsorbent, and the alumina-based Mo adsorbent layer is made of an alkali such as NaOH. It was passed through the Mo desorbent desorbs ^{Mo (99} Mo), collected and recycled as raw ^materials, desorbing the ^{Mo (99} Mo) ^99m Tc desorbent for desorbing the ^99m Tc was passed through ^{the, 99m} Tc elution method, which comprises collecting the ^99m Tc to.

1 ... ⁹⁹ Mo manufacture, 2 ... manufacture of ^99m Tc solution (TcMM), 3 ... manufacture of ^99m Tc generator column 100, 100A ... generator column, 100 ... ^99m Tc generator column (TcGC).

Claims (8)

CAMO ⁽⁹⁹ Mo) _{0 4} oxide consists of calcium Ca, and aluminum Al CAO based Mo adsorbent coupled to (hereinafter. Referred CAO).   2. The CAO-based Mo adsorbent according to claim 1, wherein a sulfate is further bonded to CAO. CaMo ⁽⁹⁹ Mo) _{0 4} Alumina based Mo adsorbent coupled to alumina.   The alumina-based Mo adsorbent according to claim 3, wherein the sulfate is further bonded to alumina. A built-in alumina based Mo adsorbent according to CAO base Mo adsorbent or claim 3 according to claim ^{1, 99m} Tc generator column to produce the ^99m Tc by adsorbing ^{Mo (99} Mo). The ^99m Tc generator column which manufactures ^99m Tc of Claim 5 ^{WHEREIN: The 99m} Tc generator column by which the sulfate salt was couple ^| bonded with CAO or alumina of CAO base Mo adsorbent or alumina base Mo adsorbent built in. Volume 2~3cc capacity of Mo adsorbent packed column ^99m Tc generator column which is commercially available is maintained, a layer of CAO base Mo ^{adsorbent CaMo} (99 Mo) _{0 4} is coupled to the CAO is the 2~3cc A ^99m Tc generator column, which is formed in a capacity-packed Mo adsorbent packed column and has a maximum of 500 mg of Mo supported on a layer of CAO-based Mo adsorbent without containing other heavy metal elements. 2~3cc capacity of the volume of Mo adsorbent packed column ^99m Tc generator column which is commercially available is maintained, a layer of alumina ^CaMo (99 Mo) _{0 4} is bonded alumina-based Mo adsorbent, the 2 A ^99m Tc generator column formed in a 3 cc capacity Mo adsorbent packed column and having a maximum of 500 mg Mo supported on an alumina-based Mo adsorbent layer without containing other heavy metal elements.

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