JP2016537414A5 - - Google Patents
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- JP2016537414A5 JP2016537414A5 JP2016552222A JP2016552222A JP2016537414A5 JP 2016537414 A5 JP2016537414 A5 JP 2016537414A5 JP 2016552222 A JP2016552222 A JP 2016552222A JP 2016552222 A JP2016552222 A JP 2016552222A JP 2016537414 A5 JP2016537414 A5 JP 2016537414A5
- Authority
- JP
- Japan
- Prior art keywords
- neural crest
- cells
- cardiac neural
- cardiac
- micrometer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000000130 stem cell Anatomy 0.000 claims description 25
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- 210000001671 embryonic stem cell Anatomy 0.000 claims description 3
- 210000004165 myocardium Anatomy 0.000 claims description 3
- 206010048858 Ischaemic cardiomyopathy Diseases 0.000 claims description 2
- 230000000302 ischemic effect Effects 0.000 claims description 2
- 210000001982 neural crest cell Anatomy 0.000 claims 20
- 108020003175 receptors Proteins 0.000 claims 13
- 102000005962 receptors Human genes 0.000 claims 13
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 238000000034 method Methods 0.000 claims 9
- 102000016971 Proto-Oncogene Proteins c-kit Human genes 0.000 claims 7
- 108010014608 Proto-Oncogene Proteins c-kit Proteins 0.000 claims 7
- 208000031229 Cardiomyopathies Diseases 0.000 claims 5
- 238000012258 culturing Methods 0.000 claims 5
- 102000045246 noggin Human genes 0.000 claims 5
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- 102000004058 Leukemia inhibitory factor Human genes 0.000 claims 4
- 108090000581 Leukemia inhibitory factor Proteins 0.000 claims 4
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- 201000010053 Alcoholic Cardiomyopathy Diseases 0.000 claims 1
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- 229960002938 bexarotene Drugs 0.000 claims 1
- 208000028831 congenital heart disease Diseases 0.000 claims 1
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- XHBVYDAKJHETMP-UHFFFAOYSA-N dorsomorphin Chemical compound C=1C=C(C2=CN3N=CC(=C3N=C2)C=2C=CN=CC=2)C=CC=1OCCN1CCCCC1 XHBVYDAKJHETMP-UHFFFAOYSA-N 0.000 claims 1
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- 101150060270 twsg1a gene Proteins 0.000 claims 1
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- 210000004027 cell Anatomy 0.000 description 8
- 210000002901 mesenchymal stem cell Anatomy 0.000 description 5
- 210000001185 bone marrow Anatomy 0.000 description 4
- 210000004413 cardiac myocyte Anatomy 0.000 description 4
- 230000007935 neutral effect Effects 0.000 description 4
- 230000002107 myocardial effect Effects 0.000 description 3
- 102000000327 E2F4 Transcription Factor Human genes 0.000 description 2
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- 241000282320 Panthera leo Species 0.000 description 2
- 230000004663 cell proliferation Effects 0.000 description 2
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- 230000002526 effect on cardiovascular system Effects 0.000 description 2
- 238000000684 flow cytometry Methods 0.000 description 2
- 230000004217 heart function Effects 0.000 description 2
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- 238000002054 transplantation Methods 0.000 description 2
- ORILYTVJVMAKLC-UHFFFAOYSA-N Adamantane Natural products C1C(C2)CC3CC1CC2C3 ORILYTVJVMAKLC-UHFFFAOYSA-N 0.000 description 1
- 206010061216 Infarction Diseases 0.000 description 1
- 235000007849 Lepidium sativum Nutrition 0.000 description 1
- 244000211187 Lepidium sativum Species 0.000 description 1
- 201000000582 Retinoblastoma Diseases 0.000 description 1
- 108700025701 Retinoblastoma Genes Proteins 0.000 description 1
- 108010017842 Telomerase Proteins 0.000 description 1
- 102100032938 Telomerase reverse transcriptase Human genes 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000002424 anti-apoptotic effect Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
- 238000013130 cardiovascular surgery Methods 0.000 description 1
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- 230000022131 cell cycle Effects 0.000 description 1
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- 208000019622 heart disease Diseases 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000007574 infarction Effects 0.000 description 1
- 230000003834 intracellular effect Effects 0.000 description 1
- 208000028867 ischemia Diseases 0.000 description 1
- 210000003716 mesoderm Anatomy 0.000 description 1
- 210000002894 multi-fate stem cell Anatomy 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- 230000008823 permeabilization Effects 0.000 description 1
- 230000035479 physiological effects, processes and functions Effects 0.000 description 1
- 210000001778 pluripotent stem cell Anatomy 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000002096 quantum dot Substances 0.000 description 1
- 230000008929 regeneration Effects 0.000 description 1
- 238000011069 regeneration method Methods 0.000 description 1
- QEVHRUUCFGRFIF-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C(C5=CC=C(OC)C=C5N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 QEVHRUUCFGRFIF-MDEJGZGSSA-N 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 238000011476 stem cell transplantation Methods 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 210000000115 thoracic cavity Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361896945P | 2013-10-29 | 2013-10-29 | |
| US61/896,945 | 2013-10-29 | ||
| PCT/US2014/062939 WO2015066197A2 (en) | 2013-10-29 | 2014-10-29 | Cardiac neural crest cells and methods of use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019000020A Division JP6832049B2 (ja) | 2013-10-29 | 2019-01-04 | 心臓神経堤細胞、及びその使用方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016537414A JP2016537414A (ja) | 2016-12-01 |
| JP2016537414A5 true JP2016537414A5 (https=) | 2017-12-14 |
Family
ID=53005371
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016552222A Pending JP2016537414A (ja) | 2013-10-29 | 2014-10-29 | 心臓神経堤細胞、及びその使用方法 |
| JP2019000020A Expired - Fee Related JP6832049B2 (ja) | 2013-10-29 | 2019-01-04 | 心臓神経堤細胞、及びその使用方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019000020A Expired - Fee Related JP6832049B2 (ja) | 2013-10-29 | 2019-01-04 | 心臓神経堤細胞、及びその使用方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (2) | US10786536B2 (https=) |
| EP (1) | EP3063267A4 (https=) |
| JP (2) | JP2016537414A (https=) |
| WO (1) | WO2015066197A2 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9962409B2 (en) | 2007-10-01 | 2018-05-08 | Vestion, Inc. | Therapy using cardiac stem cells and mesenchymal stem cells |
| US10653650B2 (en) | 2011-12-13 | 2020-05-19 | Io Therapeutics, Inc. | Treatment of diseases by concurrently eliciting remyelination effects and immunomodulatory effects using selective RXR agonists |
| MX352727B (es) | 2011-12-13 | 2017-12-06 | Dartmouth College | Tratamiento de trastorno autoinmune al usar agonistas de rxr. |
| ES2824165T3 (es) | 2012-11-30 | 2021-05-11 | Vestion Inc | Células madre cardíacas y métodos de identificación y uso de las mismas |
| KR20180121983A (ko) * | 2016-03-10 | 2018-11-09 | 아이오 테라퓨틱스, 인크. | Rxr 작용제 및 갑상선 호르몬의 조합을 사용한 근육 질환의 치료 |
| CA3016876C (en) | 2016-03-10 | 2021-12-28 | Io Therapeutics, Inc. | Treatment of autoimmune diseases with combinations of rxr agonists and thyroid hormones |
| KR102503086B1 (ko) * | 2017-09-08 | 2023-02-23 | 가부시키가이샤 오츠카 세이야쿠 고죠 | 어린 돼지 유래 줄기 세포 및 그 제조 방법 |
| US11517549B2 (en) | 2017-09-20 | 2022-12-06 | Io Therapeutics, Inc. | Treatment of disease with esters of selective RXR agonists |
| JP7330466B2 (ja) | 2017-11-30 | 2023-08-22 | 国立大学法人京都大学 | 細胞の培養方法 |
| CN108300722A (zh) * | 2018-02-11 | 2018-07-20 | 南京市妇幼保健院 | 用于检测先天性心脏病的基因panel及应用 |
| CN110652515A (zh) * | 2018-06-29 | 2020-01-07 | 中国科学院深圳先进技术研究院 | AMPK抑制剂Compound C在治疗肿瘤药物中的应用 |
| WO2022020794A1 (en) * | 2020-07-24 | 2022-01-27 | The Scripps Research Institute | Compositions comprising neural crest cell derivatives and uses thereof |
| MX2024006978A (es) | 2021-12-07 | 2024-07-19 | Io Therapeutics Inc | Uso de un agonista de rxr y taxanos en el tratamiento de cáncer her2+. |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2296704C (en) | 1997-07-14 | 2010-10-19 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US6821740B2 (en) | 1998-02-25 | 2004-11-23 | Becton, Dickinson And Company | Flow cytometric methods for the concurrent detection of discrete functional conformations of PRB in single cells |
| ATE382681T1 (de) | 1998-07-31 | 2008-01-15 | Genzyme Corp | Verbesserung der herzfunktion durch transplantation mesenchymaler stammzellen |
| US8075881B2 (en) | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
| US7547674B2 (en) | 2001-06-06 | 2009-06-16 | New York Medical College | Methods and compositions for the repair and/or regeneration of damaged myocardium |
| US6930222B2 (en) | 2000-08-22 | 2005-08-16 | The Scripps Research Institute | In vivo animal model of human leukemia |
| AU2003270051A1 (en) | 2002-08-29 | 2004-03-19 | Baylor College Of Medicine | Heart derived cells for cardiac repair |
| JP2007500756A (ja) | 2003-06-12 | 2007-01-18 | リージェンツ オブ ザ ユニバーシティ オブ ミネソタ | 組織または器官を標的化するための細胞の指向 |
| US7082573B2 (en) | 2003-07-30 | 2006-07-25 | America Online, Inc. | Method and system for managing digital assets |
| AU2004278634B2 (en) * | 2003-10-03 | 2009-10-01 | Keiichi Fukuda | Method of inducing the differentiation of stem cells into cardiomyocytes |
| JP4336821B2 (ja) | 2003-12-25 | 2009-09-30 | 有限会社金沢大学ティ・エル・オー | 哺乳動物の骨髄細胞または臍帯血由来細胞と脂肪組織を利用した心筋細胞の誘導 |
| WO2006039630A2 (en) | 2004-10-02 | 2006-04-13 | Indiana University Research & Technology Corporation | Materials and methods for identifying compounds that modulate the cell cycle |
| US20100166714A1 (en) * | 2006-11-02 | 2010-07-01 | The General Hospital Corporation | Cardiovascular stem cells, methods for stem cell isolation, and uses thereof |
| EP2079831A2 (en) | 2006-11-07 | 2009-07-22 | Keck Graduate Institute | Enriched stem cell and progenitor cell populations, and methods of producing and using such populations |
| US9962409B2 (en) | 2007-10-01 | 2018-05-08 | Vestion, Inc. | Therapy using cardiac stem cells and mesenchymal stem cells |
| AU2008333972A1 (en) * | 2007-11-30 | 2009-06-11 | New York Medical College | Compositions comprising HDAC inhibitors and methods of their use in restoring stem cell function and preventing heart failure |
| US8512696B2 (en) | 2007-11-30 | 2013-08-20 | Autologous, Llc | Methods of isolating non-senescent cardiac stem cells and uses thereof |
| US9273286B2 (en) | 2010-06-13 | 2016-03-01 | Institute Of Biophysics, Chinese Academy Of Sciences | Methods and compositions for preparing cardiomyocytes from stem cells and uses thereof |
| EP3399026B1 (en) * | 2010-06-14 | 2024-06-26 | The Scripps Research Institute | Reprogramming of cells to a new fate |
| WO2013033213A1 (en) * | 2011-08-30 | 2013-03-07 | The J. David Gladstone Institutes | Methods for generating cardiomyocytes |
| US20140162366A1 (en) * | 2012-08-31 | 2014-06-12 | Salk Institute For Biological Studies | Generation of vascular progenitor cells |
| ES2824165T3 (es) | 2012-11-30 | 2021-05-11 | Vestion Inc | Células madre cardíacas y métodos de identificación y uso de las mismas |
| US11377639B2 (en) * | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
-
2014
- 2014-10-29 EP EP14858818.9A patent/EP3063267A4/en not_active Ceased
- 2014-10-29 JP JP2016552222A patent/JP2016537414A/ja active Pending
- 2014-10-29 WO PCT/US2014/062939 patent/WO2015066197A2/en not_active Ceased
- 2014-10-29 US US15/032,965 patent/US10786536B2/en active Active - Reinstated
-
2019
- 2019-01-04 JP JP2019000020A patent/JP6832049B2/ja not_active Expired - Fee Related
-
2020
- 2020-09-28 US US17/034,883 patent/US20210260133A1/en not_active Abandoned
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