JP2016531894A5 - - Google Patents
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- Publication number
- JP2016531894A5 JP2016531894A5 JP2016519955A JP2016519955A JP2016531894A5 JP 2016531894 A5 JP2016531894 A5 JP 2016531894A5 JP 2016519955 A JP2016519955 A JP 2016519955A JP 2016519955 A JP2016519955 A JP 2016519955A JP 2016531894 A5 JP2016531894 A5 JP 2016531894A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- composition according
- pharmaceutical composition
- fungi
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 241000233866 Fungi Species 0.000 claims 2
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000004103 aminoalkyl group Chemical group 0.000 claims 1
- 229960003942 amphotericin B Drugs 0.000 claims 1
- 125000003710 aryl alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- IVRMZWNICZWHMI-UHFFFAOYSA-N azide Chemical compound [N-]=[N+]=[N-] IVRMZWNICZWHMI-UHFFFAOYSA-N 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical group 0.000 claims 1
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- XPXMKIXDFWLRAA-UHFFFAOYSA-N hydrazinide Chemical compound [NH-]N XPXMKIXDFWLRAA-UHFFFAOYSA-N 0.000 claims 1
- 150000002431 hydrogen Chemical group 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000006207 intravenous dosage form Substances 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 239000006186 oral dosage form Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 238000000844 transformation Methods 0.000 claims 1
- 230000001131 transforming Effects 0.000 claims 1
- 150000003672 ureas Chemical class 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2019183577A JP7469862B2 (ja) | 2013-10-07 | 2019-10-04 | 治療指数が改善されたアンフォテリシンｂ誘導体 |
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361887729P | 2013-10-07 | 2013-10-07 | |
| US61/887,729 | 2013-10-07 | ||
| US201462045956P | 2014-09-04 | 2014-09-04 | |
| US62/045,956 | 2014-09-04 | ||
| PCT/US2014/059334 WO2015054148A1 (en) | 2013-10-07 | 2014-10-06 | Amphotericin b derivatives with improved therapeutic index |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019183577A Division JP7469862B2 (ja) | 2013-10-07 | 2019-10-04 | 治療指数が改善されたアンフォテリシンｂ誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016531894A JP2016531894A (ja) | 2016-10-13 |
| JP2016531894A5 true JP2016531894A5 (US20070167479A1-20070719-C00034.png) | 2017-11-16 |
| JP6600303B2 JP6600303B2 (ja) | 2019-10-30 |
Family
ID=52813555
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016519955A Active JP6600303B2 (ja) | 2013-10-07 | 2014-10-06 | 治療指数が改善されたアンフォテリシンｂ誘導体 |
| JP2019183577A Active JP7469862B2 (ja) | 2013-10-07 | 2019-10-04 | 治療指数が改善されたアンフォテリシンｂ誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019183577A Active JP7469862B2 (ja) | 2013-10-07 | 2019-10-04 | 治療指数が改善されたアンフォテリシンｂ誘導体 |
Country Status (11)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2014332214B2 (en) | 2013-10-07 | 2019-10-03 | The Board Of Trustees Of The University Of Illinois | Amphotericin B derivatives with improved therapeutic index |
| BR112016028890A8 (pt) | 2014-06-12 | 2021-03-23 | Shionogi & Co | composto derivado de macrolídeo de polieno, composição farmacêutica compreendendo o referido composto e processo para a preparação do mesmo |
| EP3242554A4 (en) * | 2015-01-08 | 2018-06-06 | The Board of Trustees of the University of Illionis | Concise synthesis of urea derivatives of amphotericin b |
| EP3929203A1 (en) | 2015-04-15 | 2021-12-29 | Sfunga Therapeutics, Inc. | Derivatives of amphotericin b |
| WO2017100171A1 (en) * | 2015-12-08 | 2017-06-15 | Kalyra Pharmaceuticals, Inc. | Antifungal compounds and methods |
| EP3439668B1 (en) * | 2016-04-08 | 2024-06-19 | The Board of Trustees of the University of Illinois | Small molecule-mediated restoration of airway surface physiology in human cystic fibrosis lung epithelia |
| WO2018106571A1 (en) * | 2016-12-06 | 2018-06-14 | Kalyra Pharmaceuticals, Inc. | Antifungal compounds and methods |
| WO2020051465A1 (en) * | 2018-09-07 | 2020-03-12 | The Board Of Trustees Of The University Of Illinois | Hybrid amphotericin b derivatives with reduced toxicity |
| US20230000891A1 (en) * | 2019-08-08 | 2023-01-05 | The Board Of Trustees Of The University Of Illinois | Hybrid amphotericin b derivatives with reduced toxicity |
| CN111909226A (zh) * | 2020-08-11 | 2020-11-10 | 深圳市儿童医院 | 一种葡萄糖酸修饰的两性霉素b衍生物及其用途 |
| WO2024010968A2 (en) * | 2022-07-08 | 2024-01-11 | The Board Of Trustees Of The University Of Illinois | Transfer of c2'-epimerized sugars to the amphotericin b aglycone |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0431870A1 (en) * | 1989-12-08 | 1991-06-12 | Beecham Group p.l.c. | Amphotericin B derivatives |
| WO1993016090A1 (en) * | 1992-02-12 | 1993-08-19 | Smithkline Beecham Plc | Amphotericin b derivative |
| US8053418B2 (en) | 2005-01-24 | 2011-11-08 | Microbial Chemistry Research Foundation | Anti-penicillin resistant pneumococci agent and novel 16-membered macrolide derivative |
| AU2006226257A1 (en) | 2005-03-23 | 2006-09-28 | Consejo Superior De Investigaciones Cientificas | Polyene antibiotics, compositions containing said antibiotics, method and micro-organisms used to obtain same and applications thereof |
| US20090186838A1 (en) * | 2006-02-23 | 2009-07-23 | Eidgenössische Technische Hochschule Zürich | Amphotericin Derivatives |
| US20070238746A1 (en) * | 2006-04-06 | 2007-10-11 | Trixi Brandl | Thiazolyl-dihydro-chinazoline |
| DE102006060008A1 (de) | 2006-12-19 | 2008-06-26 | Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH | Lampe mit verbesserter Quetschungsgeometrie |
| GB0712881D0 (en) * | 2007-07-03 | 2007-08-15 | Biosergen As | Compounds |
| MX365184B (es) | 2010-12-21 | 2019-05-21 | Centro De Investig Y De Estudios Avanzados Del I P N | Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen. |
| WO2014165676A1 (en) | 2013-04-03 | 2014-10-09 | The Board Of Trustees Of The University Of Illinois | Amphotericin b derivative with reduced toxicity |
| AU2014332214B2 (en) | 2013-10-07 | 2019-10-03 | The Board Of Trustees Of The University Of Illinois | Amphotericin B derivatives with improved therapeutic index |
| EP3929203A1 (en) | 2015-04-15 | 2021-12-29 | Sfunga Therapeutics, Inc. | Derivatives of amphotericin b |
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2014
- 2014-10-06 AU AU2014332214A patent/AU2014332214B2/en active Active
- 2014-10-06 EP EP14853012.4A patent/EP3055030B1/en active Active
- 2014-10-06 WO PCT/US2014/059334 patent/WO2015054148A1/en active Application Filing
- 2014-10-06 CN CN201910693627.2A patent/CN110407898B/zh active Active
- 2014-10-06 US US15/026,520 patent/US10323057B2/en active Active
- 2014-10-06 JP JP2016519955A patent/JP6600303B2/ja active Active
- 2014-10-06 ES ES14853012.4T patent/ES2682328T3/es active Active
- 2014-10-06 KR KR1020167011985A patent/KR102321482B1/ko active IP Right Grant
- 2014-10-06 SG SG11201602570WA patent/SG11201602570WA/en unknown
- 2014-10-06 DK DK14853012.4T patent/DK3055030T3/en active
- 2014-10-06 CN CN201480065533.6A patent/CN105848721B/zh active Active
- 2014-10-06 CA CA2925904A patent/CA2925904C/en active Active
- 2014-10-06 KR KR1020217035284A patent/KR102548341B1/ko active IP Right Grant
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2019
- 2019-06-17 US US16/443,728 patent/US11117920B2/en active Active
- 2019-08-02 US US16/530,109 patent/US11028114B2/en active Active
- 2019-10-04 JP JP2019183577A patent/JP7469862B2/ja active Active
- 2019-12-09 AU AU2019279928A patent/AU2019279928B2/en active Active
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2021
- 2021-09-02 US US17/464,916 patent/US11970512B2/en active Active
