JP2016190829A - Formulation comprising active dha, enhancement food, supplement and cosmetic - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide formulations, enhancement foods, supplements and cosmetics which can improve antioxidant action.SOLUTION: Formulations according to the present invention are added to foods of specified units so that they are taken daily. The formulations contain 60-2000 mg of vitamin C, 15-1000 mg of vitamin E, 11-40 mg of zinc, 1-25 mg of lutein, 1-10 mg of zeaxanthin, and 400 mg or more of active DHA.SELECTED DRAWING: None

Description

  The present invention relates to a preparation, a fortified food, and a supplement that are effective mainly on human eyes and have an antioxidant action.

  In recent years, age-related macular degeneration (AMD) has attracted attention in human eye diseases. This age-related macular degeneration is a disease in which the macular, which is the central part of the retina, is damaged due to aging, making it difficult to see where it is going to be seen. It is the most common cause of blindness in adults in Europe and the United States, In Japan, the population has been increasing significantly in recent years due to the aging of the population and the westernization of life.

  Research to prevent this age-related macular degeneration has been conducted all over the world. For example, in a study conducted by the National Institute of Ophthalmology, 3500 subjects participated, and these subjects averaged about 6 years. A follow-up survey was conducted. In this study, it was found that subjects who received an antioxidant supplement consisting of high doses of zinc, vitamin C, vitamin E, and beta-carotene were less likely to develop the subject's disease compared to the placebo group ( Patent Document 1).

  In addition, 4200 AMD patients were subject to 5-year follow-up at 85 research centers across the United States, and attempts were made to capture new knowledge about eye nutrition from the start of the study. It was found that the addition of lutein and zeaxanthin and lutein / zeaxanthin localized in the macula without beta-carotene further reduced the risk of progressive AMD by 10%. This is thought to be because beta-carotene inhibited the absorption of lutein and zeaxanthin. The use of lutein and zeaxanthin is rather recommended for current and past smokers, especially because high doses of beta-carotene increase the risk of lung cancer.

  Recently, investigations have been carried out on whether the addition of antioxidant components such as ω-fatty acids (EPA and DHA) derived from fish oil, blueberries, sastaxanthin, and CoQ10 will lead to further improvements.

US Patent 6,660,297

  However, these antioxidant components are degraded in the process of reaching the cells, and most of the antioxidant action is lost until they are taken up into the cells, and even when taken up into the cell membrane, the antioxidant function at the cell level There was a problem that there was a limit.

  This invention is made | formed in view of the above-mentioned problem, Comprising: It aims at provision of the formulation, fortified food, supplement, and cosmetics which can improve an antioxidant effect | action.

  In order to solve the above-mentioned problems, the preparation according to the present invention is a preparation added to a predetermined unit of food intended for daily intake, and includes 60 to 2000 mg of vitamin C, 15 to 1000 mg of vitamin E, 11 It contains -40 mg zinc, 1-25 mg lutein, 1-10 mg zeaxanthin, and 400 mg or more of active DHA.

  The active DHA is preferably argatrium.

  Moreover, 0.9 mg-10 mg of copper may be included.

  In addition, vitamin C is added in an amount of 200 to 600 mg, vitamin E is added in an amount of 150 to 400 mg, zinc is added in an amount of 11 to 40 mg, copper is added in an amount of 0.9 to 2.0 mg, and lutein is added in an amount of 1 to 15 mg. May be.

  Vitamin C is added as ethyl, palmityl, lauryl, cocoyl, oleyl or stearyl ester, and zinc and copper are added as palmitate, laurate, coconut oil fatty acid salt, oleate or stearate. May be.

  Further, vitamin C may be added as a palmitate ester, and zinc and copper may be added as a palmitate.

  Also, vitamin C in the form of palmityl ester in the amount of 400 mg, vitamin E in the amount of 265 mg, zinc in the form of palmitate in the amount of 25 mg, copper in the form of palmitate in the amount of 1 mg, and lutein in the amount of 2 mg May be contained in an amount of.

  Vitamin A palmitate (20-40 mg) or beta-carotene (10-30 mg), omega-3-fatty acid triglycerides (50-200 mg), L-carnitine (25-100 mg), selenium palmitate (50-250 mcg) and One or more additional ingredients selected from the group consisting of zeaxanthin (5-25 mg) may further be included.

  Further, the fortified food according to the present invention is a fortified food of a predetermined unit intended for regular intake, and includes 60 to 2000 mg of vitamin C, 15 to 1000 mg of vitamin E, 11 to 40 mg of zinc, and 1 to 25 mg. Of lutein, 1 to 10 mg of zeaxanthin, and 400 mg or more of active DHA.

  The fortified food may be selected from the group consisting of confectionery, butter, margarine, milk, and yogurt.

  The supplement according to the present invention is a supplement of a predetermined unit intended for regular intake, and is 60 to 2000 mg of vitamin C, 15 to 1000 mg of vitamin E, 11 to 40 mg of zinc, and 1 to 25 mg of lutein. It contains 1 to 10 mg of zeaxanthin and 400 mg or more of active DHA.

  The cosmetic product according to the present invention is a predetermined unit cosmetic product intended for regular ingestion, comprising 60 to 2000 mg of vitamin C, 15 to 1000 mg of vitamin E, 11 to 40 mg of zinc, and 1 to 25 mg of lutein. It contains 1 to 10 mg of zeaxanthin and 400 mg or more of active DHA.

  According to the present invention, since the active DHA is contained, the antioxidant action can be improved. In particular, the active DHA is preferably argatrium. Argatrium is a natural component having the highest oxidizing power among the high oxidizing components existing on the market. The existing antioxidant component is degraded in the process of reaching the cell, and most of the antioxidant function is lost until it is taken up into the cell. In this respect, argatrium is taken into the cell membrane and acts on the antioxidant function of the cell itself. It also protects DNA from oxidative stress. As a result, cell oxidation stops and immunity against oxidation (aging) can be achieved.

  Next, an embodiment according to the present invention will be described.

  The preparation according to this embodiment is a preparation added to a predetermined unit of food intended for daily intake, and is 60 to 2000 mg of vitamin C, 15 to 1000 mg of vitamin E, 11 to 40 mg of zinc, 1 to Contains 25 mg lutein, 1-10 mg zeaxanthin, 400 mg or more active DHA.

  In particular, vitamin C is added in an amount of 200-600 mg, vitamin E in an amount of 150-400 mg, zinc in an amount of 11-40 mg, copper in an amount of 0.9-2.0 mg, and lutein in an amount of 1-15 mg. It is preferable.

  Also, vitamin C is in the form of palmityl ester in an amount of 500 mg, vitamin E is in an amount of 265 mg, zinc is in the form of palmitate, 25 mg, copper is in the form of palmitate, 1 mg, and lutein is 2 mg It is more preferable to contain this amount.

  Vitamin C can be added as ethyl, palmityl, lauryl, cocoyl, oleyl or stearyl ester, and zinc and copper can be added as palmitate, laurate, coconut oil fatty acid salt, oleate or stearate Good.

  Further, vitamin C may be added as a palmitate ester, and zinc and copper may be added as a palmitate.

  Vitamin A palmitate (20-40 mg) or beta-carotene (10-30 mg), omega-3-fatty acid triglyceride (50-200 mg), L-carnitine (25-100 mg), selenium palmitate (50-250 mcg) and One or more additional ingredients selected from the group consisting of zeaxanthin (5-25 mg) may further be included.

  Moreover, 0.9 mg-10 mg of copper may be included. In particular, when zinc is at a high dose, copper may be contained because copper may be reduced. However, if zinc is not at a high dose, copper may not be contained.

  The active DHA is preferably argatrium. Argatrium is a natural component having the highest oxidizing power among the high oxidizing components existing on the market. The existing antioxidant component is degraded in the process of reaching the cell, and most of the antioxidant function is lost until it is taken up into the cell. In this respect, argatrium is taken into the cell membrane and acts on the antioxidant function of the cell itself. It also protects DNA from oxidative stress. As a result, cell oxidation stops and immunity against oxidation (aging) can be achieved.

  Argatrium, when taken into the cell membrane, activates the antioxidant function of the cell itself. This is due to the fact that the structure of Argatrium is very similar to DHA in the human body. Normal DHA does not have this function. Incidentally, Argatrium itself is not an antioxidant component. On the other hand, the antioxidant components in the market (vitamin E, lutein, blueberry, astaxanthin, CoQ10, etc.) are themselves antioxidant components, but when they reach the cells, they lose their antioxidant power greatly, Even when taken up, the antioxidant function at the cellular level is limited.

  When Argatrium is used in an in vitro test using retinal cells and foreskin cells, intracellular reactive oxygen production is reduced by about 50%.

  In addition, the production of active oxygen was visually confirmed with a fluorescence microscope when argatorium was used in foreskin cells and when it was not used. While active oxygen accumulates in cells that did not use Argatrium, no increase in active oxygen was observed in cells that used Argatrium.

In addition, when argatolium is ingested, (1) the generation of superoxide (O2-) decreases.
(2) Superoxide dismutase that removes excess active oxygen is activated.
(3) Activate glutathione synthase and improve glutathione production by 200% to 300%. Overwhelmingly increased glutathione degrades hydroxy radicals.
(4) Reduces DNA damage, lipids, protein chamber peroxidation, and protects DNA from oxidative stress.

  Moreover, in the retinal cells, when comparing the antioxidant power (protective power against active oxygen) of Argatrium with niacin, cysteine, CoQ10, Vitamin E, and Vitamin C, Argatrium has an overwhelming antioxidant power. Recognize.

  In addition, in order to confirm the antioxidant power of Argatrium under intense oxidative stress, a clinical trial (University of Murcia, Spain) was conducted on athletes. Here, it was conducted for two types: professional athletes and ordinary people who exercise a few times a week. The test subjects continued exercise for 90 minutes in a state of consuming 75% of the maximum oxygen consumption in order to confirm sufficient generation of active oxygen and its antioxidant power. This improves blood antioxidant capacity (TAC), reduces lipid peroxidation (malondialdehyde), reduces 8-oxo (DNA damage), increases oxygen consumption, glucose consumption It can be seen that decreases.

  From this, Argatrium has a strong antioxidant ability (200% to 300% increase in glutathione) since the total antioxidant ability is improved and lipid peroxidation is reduced. It also protects against DNA damage as well as a 1200% reduction in DNA damage. Moreover, it becomes the level of the state before a cell receives oxidative stress, and can immunize a cell against oxidation (aging). In addition, oxygen consumption increases and exercise capacity and proof stress improve. Moreover, neutral fat is reduced by using lipid as an energy source with glucose, and it is useful for metabolic syndrome countermeasures and diet.

  Thus, the inclusion of argatrium as active DHA is effective in preventing all symptoms caused by oxidative stress and leading a lively healthy life.

  For example, when used for supplements, cosmetics, etc. as anti-aging, it is effective for various symptoms caused by aging.

  In addition, when used as a supplement for eye health, it is effective in reducing visual acuity due to retinal cell oxidation and DHA deficiency in the retina, fatigued eyes, visual abnormalities, cataracts, and the like.

  Moreover, if it uses as a metabolic syndrome countermeasure, a cholesterol value and a neutral fat value will fall large.

  In addition, when used as an immunity supplement, immunity is improved by antioxidation of cells and prevention of DNA damage.

  Further, when used as a sports food / beverage, it can withstand oxidative stress during exercise, and the exercise capacity is improved by increasing oxygen consumption (an index of exercise power).

  Moreover, if it is used as a preparation for ataxia, it is effective for ataxia in which DNA damage caused by oxidative stress is a major factor.

  Moreover, if it is used as a diet food, it can maintain lipid lowering and glucose, and is effective for dieting.

  Further, when used as an anticancer preparation, it is effective as an antitumor action of argatolium.

  In addition, DHA is recommended for pregnant women, nursing mothers, and infants because DHA is included in breast milk if used as a health support for pregnant mothers and infants. Argatrium is included in breast milk. It is effective because it is very similar to DHA.

  Moreover, if it is used for the healthy growth of the child's body, it is effective because many public institutions are taking the child's DHA.

  In addition, it is effective for all symptoms caused by cell oxidation, such as vascular diseases, medical diseases, skin diseases, cranial nerve diseases, and ophthalmic diseases.

  As mentioned above, although embodiment of this invention was described, this invention is not limited to the thing of these embodiment. Various modifications and variations can be made to these embodiments within the same range as the present invention or within an equivalent range.

Claims (12)

  A formulation added to a predetermined unit of food intended for daily consumption, comprising 60-2000 mg vitamin C, 15-1000 mg vitamin E, 11-40 mg zinc, 1-25 mg lutein, 1-10 mg A preparation comprising zeaxanthin and 400 mg or more of active DHA.   The preparation according to claim 1, wherein the active DHA is Argatrium.   The formulation according to claim 1 comprising 0.9 mg to 10 mg of copper.   An amount of 200 to 600 mg of vitamin C, an amount of 150 to 400 mg of vitamin E, an amount of 11 to 40 mg of zinc, an amount of 0.9 to 2.0 mg of copper, and an amount of 1 to 15 mg of lutein are added. Item 12. The preparation according to Item 1.   Claims where vitamin C is added as ethyl, palmityl, lauryl, cocoyl, oleyl or stearyl ester, and zinc and copper are added as palmitate, laurate, palm oil fatty acid salt, oleate or stearate Item 12. The preparation according to Item 1.   The formulation according to claim 1, wherein vitamin C is added as palmitate and zinc and copper are added as palmitate.   400 mg of vitamin C in the form of palmitic ester, 265 mg of vitamin E, 25 mg in the form of zinc palmitate, 1 mg of copper in the form of palmitate, and 2 mg of lutein The preparation according to claim 1, which is contained.   Vitamin A palmitate (20-40 mg) or beta-carotene (10-30 mg), omega-3-fatty acid triglycerides (50-200 mg), L-carnitine (25-100 mg), selenium palmitate (50-250 mcg) and zeaxanthin ( The formulation of claim 1, further comprising one or more additional ingredients selected from the group consisting of 5 to 25 mg).   A predetermined unit of fortified food intended for regular intake, 60-2000 mg vitamin C, 15-1000 mg vitamin E, 11-40 mg zinc, 1-25 mg lutein, 1-10 mg zeaxanthin, 400 mg A fortified food comprising the above active DHA.   The fortified food according to claim 9, wherein the fortified food is selected from the group consisting of confectionery, butter, margarine, milk and yogurt.   A supplement of a predetermined unit intended for regular intake, 60 to 2000 mg vitamin C, 15 to 1000 mg vitamin E, 11 to 40 mg zinc, 1 to 25 mg lutein, 1 to 10 mg zeaxanthin, 400 mg or more A supplement comprising the active DHA of   A predetermined unit cosmetic intended for regular intake, 60-2000 mg vitamin C, 15-1000 mg vitamin E, 11-40 mg zinc, 1-25 mg lutein, 1-10 mg zeaxanthin, 400 mg or more A cosmetic comprising the active DHA.